Standard name Systematic name Name description Description
ASF1 YJL115W Nucleosome assembly factor Nucleosome assembly factor; involved in chromatin assembly, disassembly; required for recovery after DSB repair; role in H3K56 acetylation required for expression homeostasis, buffering mRNA synthesis rate against gene dosage changes in S phase; anti-silencing protein, derepresses silent loci when overexpressed; role in regulating Ty1 transposition; relocalizes to cytosol under hypoxia; growth defect of asf1 null is functionally complemented by either human ASF1A or ASF1B
Visualize the interactome of ASF1
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)
G1/S 48

CYCLoPs localization & abundance

WT1 WT2 WT3
Nucleus 0.969 0.888 0.959
Cytoplasm NaN 0.052 NaN
Mito NaN 0.072 NaN

GFP localization & abundance

GFP localization GFP abundance
nucleus 6230

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
ASF1 18 0 0 0 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
RAD53 YPL153C DNA damage response kinase physical 24 4 18 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex, Co-crystal Structure, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western
HHT2 YNL031C Histone H3 physical 23 6 22 Affinity Capture-MS, Co-purification, Co-crystal Structure, Reconstituted Complex, PCA, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western
HHT1 YBR010W Histone H3 physical 22 5 21 Affinity Capture-Western, Co-purification, Affinity Capture-MS, Co-purification, Co-crystal Structure, Reconstituted Complex, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Reconstituted Complex, Reconstituted Complex
RLF2 YPR018W Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1) genetic 20 6 18 Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Lethality, Synthetic Rescue, Synthetic Growth Defect, Phenotypic Enhancement, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement, Negative Genetic, Negative Genetic, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Suppression
HHF1 YBR009C Histone H4 physical 18 5 17 Affinity Capture-MS, Affinity Capture-MS, Co-purification, Reconstituted Complex, PCA, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-MS, Reconstituted Complex, Reconstituted Complex
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 12 5 10 Synthetic Lethality, Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement, Negative Genetic, Negative Genetic, Positive Genetic
HHT1 YBR010W Histone H3 genetic 12 4 9 Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Dosage Growth Defect, Phenotypic Suppression, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Phenotypic Suppression, Negative Genetic, Negative Genetic, Synthetic Growth Defect
RRM3 YHR031C DNA helicase involved in rDNA replication and Ty1 transposition genetic 11 4 8 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Lethality, Synthetic Lethality, Phenotypic Enhancement, Negative Genetic, Negative Genetic, Phenotypic Suppression, Phenotypic Enhancement
ELG1 YOR144C Subunit of an alternative replication factor C complex genetic 11 3 8 Phenotypic Enhancement, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Phenotypic Enhancement, Negative Genetic
HTZ1 YOL012C Histone variant H2AZ genetic 10 3 10 Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement, Negative Genetic
HHF2 YNL030W Histone H4 physical 10 4 9 Affinity Capture-MS, Affinity Capture-MS, Co-purification, Reconstituted Complex, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex
HHT2 YNL031C Histone H3 genetic 10 5 7 Negative Genetic, Dosage Growth Defect, Phenotypic Suppression, Negative Genetic, Negative Genetic, Phenotypic Suppression, Phenotypic Enhancement, Synthetic Growth Defect, Negative Genetic, Negative Genetic
RAD53 YPL153C DNA damage response kinase genetic 8 7 7 Synthetic Rescue, Synthetic Growth Defect, Phenotypic Enhancement, Dosage Rescue, Dosage Rescue, Synthetic Lethality, Negative Genetic, Phenotypic Suppression
CAC2 YML102W Subunit of chromatin assembly factor I (CAF-1), with Rlf2p and Msi1p genetic 8 3 7 Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Negative Genetic, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
HHF1 YBR009C Histone H4 genetic 8 3 6 Negative Genetic, Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Lethality, Phenotypic Suppression, Negative Genetic, Negative Genetic
HIR1 YBL008W Subunit of the HIR complex physical 7 4 6 Affinity Capture-Western, Reconstituted Complex, Two-hybrid, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
RTT109 YLL002W Histone acetyltransferase genetic 7 4 6 Positive Genetic, Phenotypic Enhancement, Positive Genetic, Positive Genetic, Phenotypic Suppression, Positive Genetic, Dosage Rescue
RTT109 YLL002W Histone acetyltransferase physical 7 6 5 Affinity Capture-Western, Far Western, Affinity Capture-Western, Biochemical Activity, Affinity Capture-MS, Co-crystal Structure, Reconstituted Complex
PAT1 YCR077C Deadenylation-dependent mRNA-decapping factor genetic 7 3 5 Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Lethality, Negative Genetic, Negative Genetic, Positive Genetic
SLX5 YDL013W Subunit of the Slx5-Slx8 SUMO-targeted Ub ligase (STUbL) complex genetic 7 3 5 Negative Genetic, Synthetic Growth Defect, Negative Genetic, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic
SPT2 YER161C Protein involved in negative regulation of transcription genetic 7 2 5 Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic
CKB2 YOR039W Beta' regulatory subunit of casein kinase 2 (CK2) genetic 7 2 5 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic
CKB1 YGL019W Beta regulatory subunit of casein kinase 2 (CK2) genetic 7 2 5 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic
RAD52 YML032C Protein involved in homologous recombination genetic 6 4 5 Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Suppression, Synthetic Lethality
YAF9 YNL107W Subunit of NuA4 histone H4 acetyltransferase and SWR1 complexes genetic 6 4 5 Negative Genetic, Synthetic Growth Defect, Synthetic Lethality, Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Growth Defect
HIR2 YOR038C Subunit of HIR nucleosome assembly complex physical 6 3 5 Affinity Capture-Western, Reconstituted Complex, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
MSI1 YBR195C Subunit of chromatin assembly factor I (CAF-1) genetic 6 3 5 Phenotypic Enhancement, Negative Genetic, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
ESA1 YOR244W Catalytic subunit of the histone acetyltransferase complex (NuA4) genetic 6 2 4 Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic
TSA1 YML028W Thioredoxin peroxidase genetic 6 2 4 Negative Genetic, Negative Genetic, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic
GET2 YER083C Subunit of the GET complex genetic 6 2 4 Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
SNF2 YOR290C Catalytic subunit of the SWI/SNF chromatin remodeling complex genetic 6 2 3 Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement
CLA4 YNL298W Cdc42p-activated signal transducing kinase genetic 5 3 5 Synthetic Lethality, Negative Genetic, Synthetic Lethality, Synthetic Growth Defect, Negative Genetic
MRC1 YCL061C S-phase checkpoint protein required for DNA replication genetic 5 3 5 Dosage Rescue, Positive Genetic, Positive Genetic, Synthetic Rescue, Synthetic Rescue
NUP60 YAR002W FG-nucleoporin component of central core of the nuclear pore complex genetic 5 2 5 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic
HIR3 YJR140C Subunit of the HIR complex physical 5 1 5 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
SET2 YJL168C Histone methyltransferase with a role in transcriptional elongation genetic 5 3 4 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement
MEC1 YBR136W Genome integrity checkpoint protein and PI kinase superfamily member genetic 5 3 4 Phenotypic Enhancement, Synthetic Rescue, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect
RAD51 YER095W Strand exchange protein genetic 5 3 4 Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement, Negative Genetic
DUN1 YDL101C Cell-cycle checkpoint S/T protein kinase genetic 5 3 4 Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Suppression
SRS2 YJL092W DNA helicase and DNA-dependent ATPase genetic 5 3 4 Negative Genetic, Synthetic Growth Defect, Dosage Lethality, Dosage Lethality, Synthetic Growth Defect
SIR2 YDL042C Conserved NAD+ dependent histone deacetylase of the Sirtuin family genetic 5 3 4 Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Suppression, Synthetic Growth Defect
RAD27 YKL113C 5' to 3' exonuclease, 5' flap endonuclease genetic 5 2 4 Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Lethality, Synthetic Lethality
CIK1 YMR198W Kinesin-associated protein genetic 5 2 4 Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Lethality, Negative Genetic
RPN4 YDL020C Transcription factor that stimulates expression of proteasome genes genetic 5 2 4 Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic
CLB2 YPR119W B-type cyclin involved in cell cycle progression genetic 5 2 4 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic
RPA14 YDR156W RNA polymerase I subunit A14 genetic 5 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
BUB2 YMR055C Mitotic exit network regulator genetic 5 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SLX8 YER116C Subunit of Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex genetic 5 2 3 Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic
CSM1 YCR086W Nucleolar protein that mediates homolog segregation during meiosis I genetic 5 2 3 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
MED1 YPR070W Subunit of the RNA polymerase II mediator complex genetic 5 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
UBC4 YBR082C Ubiquitin-conjugating enzyme (E2) genetic 5 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes genetic 4 3 4 Synthetic Lethality, Phenotypic Enhancement, Synthetic Lethality, Negative Genetic
SIR1 YKR101W Protein involved in silencing at mating-type loci HML and HMR genetic 4 3 4 Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Phenotypic Enhancement
VPS72 YDR485C Htz1p-binding component of the SWR1 complex genetic 4 3 4 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Phenotypic Enhancement
SWC5 YBR231C Component of the SWR1 complex genetic 4 3 4 Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement
VPS71 YML041C Nucleosome-binding component of the SWR1 complex genetic 4 3 4 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Phenotypic Enhancement
RPD3 YNL330C Histone deacetylase, component of both the Rpd3S and Rpd3L complexes genetic 4 3 4 Phenotypic Enhancement, Synthetic Growth Defect, Negative Genetic, Negative Genetic
PPH3 YDR075W Catalytic subunit of protein phosphatase PP4 complex genetic 4 2 4 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic
NUP84 YDL116W Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) genetic 4 2 4 Negative Genetic, Negative Genetic, Synthetic Lethality, Negative Genetic
TCO89 YPL180W Subunit of TORC1 (Tor1p or Tor2p-Kog1p-Lst8p-Tco89p) genetic 4 2 4 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect
DST1 YGL043W General transcription elongation factor TFIIS genetic 4 2 4 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic
DOA1 YKL213C WD-repeat protein involved in ubiquitin-mediated protein degradation genetic 4 2 4 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic
LSM6 YDR378C Lsm (Like Sm) protein genetic 4 2 4 Negative Genetic, Negative Genetic, Synthetic Lethality, Negative Genetic
SOH1 YGL127C Subunit of the RNA polymerase II mediator complex genetic 4 2 4 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic
HTB1 YDR224C Histone H2B genetic 4 3 3 Phenotypic Suppression, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement
RAD55 YDR076W Protein that stimulates strand exchange genetic 4 3 3 Phenotypic Enhancement, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect
CTF4 YPR135W Chromatin-associated protein genetic 4 3 3 Positive Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Rescue
SPT16 YGL207W Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) genetic 4 3 3 Synthetic Lethality, Dosage Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect
RPN10 YHR200W Proteasome polyubiquitin receptor genetic 4 2 3 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect
EAF1 YDR359C Component of the NuA4 histone acetyltransferase complex genetic 4 2 3 Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect
CCS1 YMR038C Copper chaperone for superoxide dismutase Sod1p genetic 4 2 3 Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect
YAP1 YML007W Basic leucine zipper (bZIP) transcription factor genetic 4 2 3 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic
HDA1 YNL021W Catalytic subunit of class II HDA1 histone deacetylase complex genetic 4 2 3 Negative Genetic, Negative Genetic, Negative Genetic, Phenotypic Enhancement
SIN3 YOL004W Component of both the Rpd3S and Rpd3L histone deacetylase complexes genetic 4 2 3 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic
PHO23 YNL097C Component of the Rpd3L histone deacetylase complex genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
PSH1 YOL054W E3 ubiquitin ligase targeting centromere-binding protein Cse4p genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
RNH203 YLR154C Ribonuclease H2 subunit genetic 4 3 2 Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement, Negative Genetic
MKK2 YPL140C MAPKK involved in the protein kinase C signaling pathway genetic 4 1 2 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
VIP1 YLR410W Bifunctional inositol pyrophosphate kinase and phosphatase physical 4 4 1 Affinity Capture-MS, Reconstituted Complex, Affinity Capture-Western, Co-fractionation
TAF1 YGR274C TFIID subunit, involved in RNA pol II transcription initiation genetic 3 3 3 Dosage Rescue, Negative Genetic, Synthetic Lethality
HHF2 YNL030W Histone H4 genetic 3 3 3 Synthetic Lethality, Phenotypic Suppression, Negative Genetic
POL30 YBR088C Proliferating cell nuclear antigen (PCNA) genetic 3 3 3 Synthetic Growth Defect, Negative Genetic, Phenotypic Enhancement
CTK1 YKL139W Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I) genetic 3 3 3 Synthetic Lethality, Synthetic Growth Defect, Positive Genetic
HTA1 YDR225W Histone H2A genetic 3 3 3 Phenotypic Suppression, Synthetic Growth Defect, Negative Genetic
ARP8 YOR141C Nuclear actin-related protein involved in chromatin remodeling genetic 3 3 3 Phenotypic Enhancement, Negative Genetic, Synthetic Growth Defect
SAS2 YMR127C Histone acetyltransferase (HAT) catalytic subunit of the SAS complex genetic 3 2 3 Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Suppression
RFC5 YBR087W Subunit of heteropentameric Replication factor C (RF-C) genetic 3 2 3 Phenotypic Enhancement, Phenotypic Enhancement, Negative Genetic
HIF1 YLL022C Non-essential component of the HAT-B histone acetyltransferase complex physical 3 2 3 Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western
SPN1 YPR133C Protein involved in RNA polymerase II transcription genetic 3 2 3 Negative Genetic, Synthetic Growth Defect, Negative Genetic
SMT3 YDR510W Ubiquitin-like protein of the SUMO family genetic 3 2 3 Negative Genetic, Synthetic Growth Defect, Negative Genetic
TEL1 YBL088C Protein kinase primarily involved in telomere length regulation genetic 3 2 3 Synthetic Rescue, Negative Genetic, Negative Genetic
POL1 YNL102W Catalytic subunit of the DNA polymerase I alpha-primase complex genetic 3 2 3 Synthetic Growth Defect, Synthetic Rescue, Synthetic Growth Defect
MEC3 YLR288C DNA damage and meiotic pachytene checkpoint protein genetic 3 2 3 Phenotypic Enhancement, Negative Genetic, Negative Genetic
UBP6 YFR010W Ubiquitin-specific protease genetic 3 2 3 Negative Genetic, Synthetic Growth Defect, Negative Genetic
LSM7 YNL147W Lsm (Like Sm) protein genetic 3 2 3 Negative Genetic, Negative Genetic, Synthetic Lethality
CDC73 YLR418C Component of the Paf1p complex genetic 3 2 3 Negative Genetic, Synthetic Growth Defect, Negative Genetic
EAF3 YPR023C Component of the Rpd3S histone deacetylase complex genetic 3 2 3 Negative Genetic, Negative Genetic, Phenotypic Enhancement
LTE1 YAL024C Protein similar to GDP/GTP exchange factors genetic 3 2 3 Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
SHP1 YBL058W UBX domain-containing substrate adaptor for Cdc48p genetic 3 2 3 Negative Genetic, Synthetic Lethality, Negative Genetic
SET1 YHR119W Histone methyltransferase, subunit of the COMPASS (Set1C) complex genetic 3 2 3 Negative Genetic, Negative Genetic, Phenotypic Suppression
ARP6 YLR085C Actin-related protein that binds nucleosomes genetic 3 2 3 Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
HPC2 YBR215W Subunit of the HIR complex physical 3 1 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
SEC22 YLR268W R-SNARE protein genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
BUB1 YGR188C Protein kinase involved in the cell cycle checkpoint into anaphase genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
RCO1 YMR075W Essential component of the Rpd3S histone deacetylase complex genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
USO1 YDL058W Essential protein involved in vesicle-mediated ER to Golgi transport genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
SUS1 YBR111W-A Global transcriptional regulator, component of SAGA, TREX-2 complexes genetic 3 3 2 Negative Genetic, Synthetic Growth Defect, Phenotypic Suppression
RAD9 YDR217C DNA damage-dependent checkpoint protein genetic 3 3 2 Phenotypic Enhancement, Synthetic Rescue, Synthetic Growth Defect
POB3 YML069W Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) genetic 3 3 2 Synthetic Lethality, Dosage Growth Defect, Negative Genetic
MSH2 YOL090W Protein that binds to DNA mismatches genetic 3 3 2 Phenotypic Suppression, Phenotypic Enhancement, Negative Genetic
NCB2 YDR397C Subunit of a heterodimeric NC2 transcription regulator complex genetic 3 3 2 Synthetic Growth Defect, Phenotypic Enhancement, Negative Genetic
SAS2 YMR127C Histone acetyltransferase (HAT) catalytic subunit of the SAS complex physical 3 2 2 Affinity Capture-Western, Affinity Capture-Western, Two-hybrid
SAS4 YDR181C Subunit of the SAS complex (Sas2p, Sas4p, Sas5p) physical 3 2 2 Affinity Capture-Western, Affinity Capture-Western, Two-hybrid
RAD50 YNL250W Subunit of MRX complex with Mre11p and Xrs2p genetic 3 2 2 Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect
RAD54 YGL163C DNA-dependent ATPase that stimulates strand exchange genetic 3 2 2 Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect
RAD57 YDR004W Protein that stimulates strand exchange genetic 3 2 2 Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect
MMS22 YLR320W Subunit of E3 ubiquitin ligase complex involved in replication repair genetic 3 2 2 Positive Genetic, Synthetic Growth Defect, Synthetic Growth Defect
CDC20 YGL116W Activator of anaphase-promoting complex/cyclosome (APC/C) genetic 3 2 2 Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
RAD5 YLR032W DNA helicase/Ubiquitin ligase genetic 3 2 2 Phenotypic Suppression, Synthetic Growth Defect, Synthetic Growth Defect
NPT1 YOR209C Nicotinate phosphoribosyltransferase genetic 3 2 2 Negative Genetic, Negative Genetic, Synthetic Growth Defect
SAE2 YGL175C Endonuclease required for telomere elongation genetic 3 2 2 Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
LGE1 YPL055C Protein involved in histone H2B ubiquitination genetic 3 2 2 Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
POL32 YJR043C Third subunit of DNA polymerase delta genetic 3 2 2 Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Suppression
DIA2 YOR080W Origin-binding F-box protein genetic 3 2 2 Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
CMR1 YDL156W Nuclear protein with role in transcription, protein quality control genetic 3 2 2 Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
FRK1 YPL141C Protein kinase of unknown cellular role genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
RAD18 YCR066W E3 ubiquitin ligase genetic 3 1 2 Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect
BRE1 YDL074C E3 ubiquitin ligase genetic 3 1 2 Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect
RAD6 YGL058W Ubiquitin-conjugating enzyme (E2) genetic 3 1 2 Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect
NRG1 YDR043C Transcriptional repressor genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
PAC11 YDR488C Dynein intermediate chain, microtubule motor protein genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
BUD27 YFL023W Unconventional prefoldin protein involved in translation initiation genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
CSM2 YIL132C Subunit of the Shu complex (aka PCSS complex) genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
HOM6 YJR139C Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase) genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
YKL033W-A YKL033W-A Protein of unknown function genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
MSC1 YML128C Protein of unknown function genetic 3 1 2 Positive Genetic, Positive Genetic, Positive Genetic
DYN3 YMR299C Dynein light intermediate chain (LIC) genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
PAC1 YOR269W Regulator of dynein, involved in intracellular transport genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
MDL2 YPL270W Mitochondrial inner membrane half-type ABC transporter genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
CUP9 YPL177C Homeodomain-containing transcriptional repressor genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
SET2 YJL168C Histone methyltransferase with a role in transcriptional elongation physical 3 2 1 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western
SUS1 YBR111W-A Global transcriptional regulator, component of SAGA, TREX-2 complexes physical 3 2 1 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western
SAS5 YOR213C Subunit of the SAS complex (Sas2p, Sas4p, Sas5p) physical 2 2 2 Affinity Capture-Western, Two-hybrid
HIR1 YBL008W Subunit of the HIR complex genetic 2 2 2 Phenotypic Enhancement, Phenotypic Suppression
TAF7 YMR227C TFIID subunit (67 kDa) genetic 2 2 2 Dosage Rescue, Negative Genetic
BDF1 YLR399C BET family transcriptional regulator physical 2 2 2 Affinity Capture-Western, Reconstituted Complex
RFC1 YOR217W Subunit of heteropentameric Replication factor C (RF-C) genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
HAT2 YEL056W Subunit of the Hat1p-Hat2p histone acetyltransferase complex physical 2 2 2 Affinity Capture-Western, Affinity Capture-MS
HAT1 YPL001W Catalytic subunit of the Hat1p-Hat2p histone acetyltransferase complex physical 2 2 2 Affinity Capture-Western, Affinity Capture-MS
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit physical 2 2 2 Biochemical Activity, PCA
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit genetic 2 2 2 Phenotypic Enhancement, Synthetic Growth Defect
SNF2 YOR290C Catalytic subunit of the SWI/SNF chromatin remodeling complex physical 2 2 2 Co-localization, Affinity Capture-Western
CHK1 YBR274W Serine/threonine kinase and DNA damage checkpoint effector genetic 2 2 2 Phenotypic Enhancement, Synthetic Rescue
RAD24 YER173W Checkpoint protein genetic 2 2 2 Phenotypic Enhancement, Synthetic Rescue
TAF3 YPL011C TFIID subunit (47 kDa) genetic 2 2 2 Dosage Rescue, Negative Genetic
SPT4 YGR063C Spt4p/5p (DSIF) transcription elongation factor complex subunit genetic 2 2 2 Negative Genetic, Synthetic Lethality
VPS8 YAL002W Membrane-binding component of the CORVET complex genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
PDA1 YER178W E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex genetic 2 2 2 Negative Genetic, Phenotypic Suppression
HUR1 YGL168W Protein with a role in DNA repair genetic 2 2 2 Negative Genetic, Synthetic Lethality
BRE2 YLR015W Subunit of COMPASS (Set1C) complex genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
UBA3 YPR066W Protein that activates Rub1p (NEDD8) before neddylation genetic 2 2 2 Positive Genetic, Negative Genetic
MON2 YNL297C Protein with a role in endocytosis and vacuole integrity genetic 2 2 2 Positive Genetic, Synthetic Lethality
PAP2 YOL115W Non-canonical poly(A) polymerase genetic 2 2 2 Synthetic Lethality, Synthetic Growth Defect
SKN7 YHR206W Nuclear response regulator and transcription factor genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
SWR1 YDR334W Swi2/Snf2-related ATPase genetic 2 2 2 Synthetic Growth Defect, Phenotypic Enhancement
SIC1 YLR079W Cyclin-dependent kinase inhibitor (CKI) genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
CDH1 YGL003C Activator of anaphase-promoting complex/cyclosome (APC/C) genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
STP22 YCL008C Component of the ESCRT-I complex genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
CTK3 YML112W Gamma subunit of C-terminal domain kinase I genetic 2 2 2 Synthetic Lethality, Negative Genetic
LSM1 YJL124C Lsm (Like Sm) protein genetic 2 2 2 Synthetic Lethality, Positive Genetic
PMR1 YGL167C High affinity Ca2+/Mn2+ P-type ATPase genetic 2 2 2 Synthetic Lethality, Negative Genetic
POL2 YNL262W Catalytic subunit of DNA polymerase (II) epsilon genetic 2 2 2 Phenotypic Suppression, Synthetic Growth Defect
HRQ1 YDR291W 3'-5' DNA helicase of the conserved RecQ family genetic 2 2 2 Negative Genetic, Positive Genetic
HST3 YOR025W Sirtuin, histone H3 deacetylase genetic 2 2 2 Phenotypic Suppression, Synthetic Rescue
TUB2 YFL037W Beta-tubulin genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
PTC2 YER089C Type 2C protein phosphatase (PP2C) genetic 2 2 2 Negative Genetic, Phenotypic Suppression
APC5 YOR249C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 2 2 2 Phenotypic Enhancement, Synthetic Rescue
RTT106 YNL206C Histone chaperone genetic 2 1 2 Phenotypic Suppression, Phenotypic Suppression
RPA34 YJL148W RNA polymerase I subunit A34.5 genetic 2 1 2 Negative Genetic, Negative Genetic
RIC1 YLR039C Protein involved in retrograde transport to the cis-Golgi network genetic 2 1 2 Negative Genetic, Negative Genetic
CSE2 YNR010W Subunit of the RNA polymerase II mediator complex genetic 2 1 2 Negative Genetic, Negative Genetic
ORM2 YLR350W Protein that mediates sphingolipid homeostasis genetic 2 1 2 Negative Genetic, Negative Genetic
BUB3 YOR026W Kinetochore checkpoint WD40 repeat protein genetic 2 1 2 Negative Genetic, Negative Genetic
MCK1 YNL307C Dual-specificity ser/thr and tyrosine protein kinase genetic 2 1 2 Negative Genetic, Negative Genetic
SWD3 YBR175W Essential subunit of the COMPASS (Set1C) complex genetic 2 1 2 Negative Genetic, Negative Genetic
YTA7 YGR270W Chromatin-binding ATPase that regulates histone gene expression genetic 2 1 2 Synthetic Growth Defect, Synthetic Growth Defect
PHO85 YPL031C Cyclin-dependent kinase genetic 2 1 2 Synthetic Growth Defect, Synthetic Growth Defect
BCK1 YJL095W MAPKKK acting in the protein kinase C signaling pathway genetic 2 1 2 Negative Genetic, Negative Genetic
POL12 YBL035C B subunit of DNA polymerase alpha-primase complex genetic 2 1 2 Negative Genetic, Negative Genetic
MED8 YBR193C Subunit of the RNA polymerase II mediator complex genetic 2 1 2 Negative Genetic, Negative Genetic
CDC48 YDL126C AAA ATPase with protein-unfoldase activity genetic 2 1 2 Negative Genetic, Negative Genetic
POL3 YDL102W Catalytic subunit of DNA polymerase delta genetic 2 1 2 Negative Genetic, Negative Genetic
MCD1 YDL003W Essential alpha-kleisin subunit of the cohesin complex genetic 2 1 2 Negative Genetic, Negative Genetic
WBP1 YEL002C Beta subunit of the oligosaccharyl transferase glycoprotein complex genetic 2 1 2 Positive Genetic, Positive Genetic
MDM31 YHR194W Mitochondrial protein that may have a role in phospholipid metabolism genetic 2 1 2 Positive Genetic, Positive Genetic
MAL12 YGR292W Maltase (alpha-D-glucosidase) genetic 2 1 2 Negative Genetic, Negative Genetic
IES2 YNL215W Protein that associates with the INO80 chromatin remodeling complex genetic 2 1 2 Negative Genetic, Negative Genetic
RPT4 YOR259C ATPase of the 19S regulatory particle of the 26S proteasome genetic 2 1 2 Negative Genetic, Negative Genetic
TOP1 YOL006C Topoisomerase I genetic 2 1 2 Synthetic Growth Defect, Synthetic Growth Defect
SAP30 YMR263W Component of Rpd3L histone deacetylase complex genetic 2 1 2 Synthetic Growth Defect, Synthetic Growth Defect
NPL3 YDR432W RNA-binding protein genetic 2 1 2 Synthetic Growth Defect, Synthetic Growth Defect
OKP1 YGR179C Outer kinetochore protein required for accurate chromosome segregation genetic 2 1 2 Negative Genetic, Negative Genetic
SDC1 YDR469W Subunit of the COMPASS (Set1C) complex genetic 2 1 2 Negative Genetic, Negative Genetic
SRN2 YLR119W Component of the ESCRT-I complex genetic 2 1 2 Negative Genetic, Negative Genetic
APQ12 YIL040W Nuclear envelope/ER integral membrane protein genetic 2 1 2 Negative Genetic, Negative Genetic
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex genetic 2 2 1 Synthetic Lethality, Synthetic Growth Defect
DNA2 YHR164C ATP-dependent 5'-flap endonuclease and DNA helicase genetic 2 2 1 Synthetic Lethality, Synthetic Growth Defect
POP2 YNR052C Subunit of Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation genetic 2 2 1 Synthetic Lethality, Synthetic Growth Defect
MOT1 YPL082C Essential protein involved in regulation of transcription genetic 2 2 1 Synthetic Growth Defect, Phenotypic Enhancement
BUR6 YER159C Subunit of a heterodimeric NC2 transcription regulator complex genetic 2 2 1 Synthetic Growth Defect, Phenotypic Enhancement
ISW1 YBR245C ATPase subunit of imitation-switch (ISWI) class chromatin remodelers genetic 2 2 1 Synthetic Growth Defect, Phenotypic Enhancement
CSE4 YKL049C Centromeric histone H3-like protein genetic 2 2 1 Dosage Lethality, Negative Genetic
ARP4 YJL081C Nuclear actin-related protein involved in chromatin remodeling genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
SSB1 YDL229W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 2 1 1 Affinity Capture-MS, Affinity Capture-MS
TAF9 YMR236W Subunit (17 kDa) of TFIID and SAGA complexes genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
THP1 YOL072W Nuclear pore-associated protein physical 2 1 1 Affinity Capture-MS, Affinity Capture-MS
EPL1 YFL024C Subunit of NuA4, an essential histone H4/H2A acetyltransferase complex genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
YNG2 YHR090C Subunit of NuA4, an essential histone acetyltransferase complex genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
GLC7 YER133W Type 1 S/T protein phosphatase (PP1) catalytic subunit genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
EMI2 YDR516C Hexokinase expressed during growth with low glucose levels genetic 2 1 1 Negative Genetic, Negative Genetic
SPS2 YDR522C Protein expressed during sporulation genetic 2 1 1 Negative Genetic, Negative Genetic
YUH1 YJR099W Ubiquitin C-terminal hydrolase genetic 2 1 1 Negative Genetic, Negative Genetic
YJR120W YJR120W Protein of unknown function genetic 2 1 1 Negative Genetic, Negative Genetic
MRE11 YMR224C Nuclease subunit of the MRX complex with Rad50p and Xrs2p genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
XRS2 YDR369C FHA domain-containing component of the Mre11 complex genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
MMS1 YPR164W Subunit of E3 ubiquitin ligase complex involved in replication repair genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
RTT107 YHR154W BRCA1 C-terminal domain protein needed for recovery from DNA damage genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
LRS4 YDR439W Nucleolar protein that forms a complex with Csm1p genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
CTF18 YMR078C Subunit of a complex with Ctf8p genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
CTF8 YHR191C Subunit of a complex with Ctf18p genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
DCC1 YCL016C Subunit of a complex with Ctf8p and Ctf18p genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
GET1 YGL020C Subunit of the GET complex genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
SFP1 YLR403W Regulates transcription of ribosomal protein and biogenesis genes regulation 1 1 1 DNA to cDNA expression microarray evidence
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
TFC7 YOR110W RNA pol III transcription initiation factor complex (TFIIIC) subunit regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SPT3 YDR392W Subunit of the SAGA and SAGA-like transcriptional regulatory complexes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SPT7 YBR081C Subunit of the SAGA transcriptional regulatory complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SKN7 YHR206W Nuclear response regulator and transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
FHL1 YPR104C Regulator of ribosomal protein (RP) transcription regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SWI6 YLR182W Transcription cofactor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MBP1 YDL056W Transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
GPG1 YGL121C Proposed gamma subunit of the heterotrimeric G protein regulation 1 1 1 quantitative reverse transcription polymerase chain reaction evidence
NCA3 YJL116C Protein involved in mitochondrion organization regulation 1 1 1 quantitative reverse transcription polymerase chain reaction evidence
SNZ2 YNL333W Protein involved in thiamine and pyridoxine biosynthesis regulation 1 1 1 northern blot evidence
SNO1 YMR095C Protein of unconfirmed function regulation 1 1 1 northern blot evidence
SNO2 YNL334C Protein of unknown function regulation 1 1 1 northern blot evidence
GAC1 YOR178C Regulatory subunit for Glc7p type-1 protein phosphatase (PP1) regulation 1 1 1 quantitative reverse transcription polymerase chain reaction evidence
SNZ1 YMR096W Subunit of a two-component pyridoxal-5'-phosphate synthase regulation 1 1 1 northern blot evidence
XBP1 YIL101C Transcriptional repressor regulation 1 1 1 quantitative reverse transcription polymerase chain reaction evidence
AOS1 YPR180W Subunit of heterodimeric nuclear SUMO activating enzyme E1 with Uba2p genetic 1 1 1 Negative Genetic
APL6 YGR261C Beta3-like subunit of the yeast AP-3 complex genetic 1 1 1 Negative Genetic
ARC18 YLR370C Subunit of the ARP2/3 complex genetic 1 1 1 Synthetic Lethality
ARC35 YNR035C Subunit of the ARP2/3 complex genetic 1 1 1 Negative Genetic
ARD1 YHR013C Subunit of protein N-terminal acetyltransferase NatA genetic 1 1 1 Positive Genetic
MAM33 YIL070C Acidic protein of the mitochondrial matrix physical 1 1 1 Affinity Capture-MS
RNR2 YJL026W Ribonucleotide-diphosphate reductase (RNR), small subunit physical 1 1 1 Affinity Capture-MS
RNR4 YGR180C Ribonucleotide-diphosphate reductase (RNR) small subunit physical 1 1 1 Affinity Capture-MS
SAS4 YDR181C Subunit of the SAS complex (Sas2p, Sas4p, Sas5p) genetic 1 1 1 Negative Genetic
SAS5 YOR213C Subunit of the SAS complex (Sas2p, Sas4p, Sas5p) genetic 1 1 1 Negative Genetic
TAF7 YMR227C TFIID subunit (67 kDa) physical 1 1 1 Affinity Capture-Western
TAF1 YGR274C TFIID subunit, involved in RNA pol II transcription initiation physical 1 1 1 Affinity Capture-Western
SPT15 YER148W TATA-binding protein (TBP) physical 1 1 1 Affinity Capture-Western
SPT15 YER148W TATA-binding protein (TBP) genetic 1 1 1 Dosage Rescue
BDF1 YLR399C BET family transcriptional regulator genetic 1 1 1 Synthetic Lethality
BDF2 YDL070W Protein involved in transcription initiation physical 1 1 1 Affinity Capture-Western
RFC1 YOR217W Subunit of heteropentameric Replication factor C (RF-C) physical 1 1 1 Affinity Capture-Western
RFC2 YJR068W Subunit of heteropentameric Replication factor C (RF-C) physical 1 1 1 Affinity Capture-Western
RFC2 YJR068W Subunit of heteropentameric Replication factor C (RF-C) genetic 1 1 1 Negative Genetic
RFC3 YNL290W Subunit of heteropentameric Replication factor C (RF-C) physical 1 1 1 Affinity Capture-Western
RFC4 YOL094C Subunit of heteropentameric Replication factor C (RF-C) physical 1 1 1 Affinity Capture-Western
RFC4 YOL094C Subunit of heteropentameric Replication factor C (RF-C) genetic 1 1 1 Negative Genetic
RFC5 YBR087W Subunit of heteropentameric Replication factor C (RF-C) physical 1 1 1 Affinity Capture-Western
RFA1 YAR007C Subunit of heterotrimeric Replication Protein A (RPA) physical 1 1 1 Affinity Capture-MS
CMD1 YBR109C Calmodulin physical 1 1 1 Affinity Capture-MS
CKA1 YIL035C Alpha catalytic subunit of casein kinase 2 (CK2) physical 1 1 1 Affinity Capture-MS
CKA1 YIL035C Alpha catalytic subunit of casein kinase 2 (CK2) genetic 1 1 1 Negative Genetic
QDR2 YIL121W Plasma membrane transporter of the major facilitator superfamily physical 1 1 1 Affinity Capture-MS
RPC19 YNL113W RNA polymerase subunit AC19 physical 1 1 1 Affinity Capture-MS
CKA2 YOR061W Alpha' catalytic subunit of casein kinase 2 (CK2) physical 1 1 1 Affinity Capture-MS
SFP1 YLR403W Regulates transcription of ribosomal protein and biogenesis genes physical 1 1 1 Affinity Capture-MS
FRK1 YPL141C Protein kinase of unknown cellular role physical 1 1 1 Biochemical Activity
KAP123 YER110C Karyopherin beta physical 1 1 1 Reconstituted Complex
HIF1 YLL022C Non-essential component of the HAT-B histone acetyltransferase complex genetic 1 1 1 Phenotypic Enhancement
HAT2 YEL056W Subunit of the Hat1p-Hat2p histone acetyltransferase complex genetic 1 1 1 Negative Genetic
HAT1 YPL001W Catalytic subunit of the Hat1p-Hat2p histone acetyltransferase complex genetic 1 1 1 Phenotypic Enhancement
ESA1 YOR244W Catalytic subunit of the histone acetyltransferase complex (NuA4) physical 1 1 1 Biochemical Activity
GIS2 YNL255C Translational activator for mRNAs with internal ribosome entry sites physical 1 1 1 Affinity Capture-RNA
RSC8 YFR037C Component of the RSC chromatin remodeling complex physical 1 1 1 Co-localization
RSP5 YER125W NEDD4 family E3 ubiquitin ligase physical 1 1 1 Protein-peptide
SHM1 YBR263W Mitochondrial serine hydroxymethyltransferase physical 1 1 1 Affinity Capture-MS
CAC2 YML102W Subunit of chromatin assembly factor I (CAF-1), with Rlf2p and Msi1p physical 1 1 1 Reconstituted Complex
RPA190 YOR341W RNA polymerase I largest subunit A190 physical 1 1 1 Affinity Capture-Western
RPC82 YPR190C RNA polymerase III subunit C82 physical 1 1 1 Affinity Capture-MS
SPN1 YPR133C Protein involved in RNA polymerase II transcription physical 1 1 1 Affinity Capture-MS
NUP60 YAR002W FG-nucleoporin component of central core of the nuclear pore complex physical 1 1 1 Affinity Capture-MS
TAF12 YDR145W Subunit (61/68 kDa) of TFIID and SAGA complexes physical 1 1 1 Affinity Capture-MS
NUP2 YLR335W Nucleoporin involved in nucleocytoplasmic transport physical 1 1 1 Affinity Capture-MS
UBP3 YER151C Ubiquitin-specific protease that cleaves Ub-protein fusions physical 1 1 1 Affinity Capture-MS
HTB2 YBL002W Histone H2B physical 1 1 1 Affinity Capture-MS
TFG2 YGR005C TFIIF (Transcription Factor II) middle subunit physical 1 1 1 Affinity Capture-MS
HTZ1 YOL012C Histone variant H2AZ physical 1 1 1 Affinity Capture-MS
TRA1 YHR099W Subunit of SAGA and NuA4 histone acetyltransferase complexes physical 1 1 1 Affinity Capture-MS
SPT7 YBR081C Subunit of the SAGA transcriptional regulatory complex physical 1 1 1 Affinity Capture-MS
TAF5 YBR198C Subunit (90 kDa) of TFIID and SAGA complexes physical 1 1 1 Affinity Capture-MS
SGF73 YGL066W Subunit of DUBm module of SAGA and SLIK physical 1 1 1 Affinity Capture-MS
NGG1 YDR176W Subunit of chromatin modifying histone acetyltransferase complexes physical 1 1 1 Affinity Capture-MS
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes physical 1 1 1 Affinity Capture-MS
UBP8 YMR223W Ubiquitin-specific protease component of the SAGA acetylation complex physical 1 1 1 Affinity Capture-MS
HFI1 YPL254W Adaptor protein required for structural integrity of the SAGA complex physical 1 1 1 Affinity Capture-MS
HFI1 YPL254W Adaptor protein required for structural integrity of the SAGA complex genetic 1 1 1 Negative Genetic
SPT3 YDR392W Subunit of the SAGA and SAGA-like transcriptional regulatory complexes physical 1 1 1 Affinity Capture-MS
TAF6 YGL112C Subunit (60 kDa) of TFIID and SAGA complexes physical 1 1 1 Affinity Capture-MS
SPT20 YOL148C Subunit of the SAGA transcriptional regulatory complex physical 1 1 1 Affinity Capture-MS
SGF29 YCL010C Component of the HAT/Core module of the SAGA, SLIK, and ADA complexes physical 1 1 1 Affinity Capture-MS
SGF29 YCL010C Component of the HAT/Core module of the SAGA, SLIK, and ADA complexes genetic 1 1 1 Negative Genetic
TAF9 YMR236W Subunit (17 kDa) of TFIID and SAGA complexes physical 1 1 1 Affinity Capture-MS
TAF10 YDR167W Subunit (145 kDa) of TFIID and SAGA complexes physical 1 1 1 Affinity Capture-MS
SGF11 YPL047W Integral subunit of SAGA histone acetyltransferase complex physical 1 1 1 Affinity Capture-MS
SAC3 YDR159W mRNA export factor physical 1 1 1 Affinity Capture-MS
THP1 YOL072W Nuclear pore-associated protein genetic 1 1 1 Negative Genetic
CDC31 YOR257W Calcium-binding component of the spindle pole body (SPB) half-bridge physical 1 1 1 Affinity Capture-MS
YRA1 YDR381W Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-MS
YRA1 YDR381W Nuclear polyadenylated RNA-binding protein genetic 1 1 1 Negative Genetic
HTB1 YDR224C Histone H2B physical 1 1 1 Affinity Capture-MS
RTT103 YDR289C Protein involved in transcription termination by RNA polymerase II physical 1 1 1 Affinity Capture-MS
SPT5 YML010W Spt4p/5p (DSIF) transcription elongation factor complex subunit physical 1 1 1 Affinity Capture-MS
NUP57 YGR119C FG-nucleoporin component of central core of the nuclear pore complex physical 1 1 1 Affinity Capture-MS
HTA2 YBL003C Histone H2A physical 1 1 1 Affinity Capture-MS
SMT3 YDR510W Ubiquitin-like protein of the SUMO family physical 1 1 1 Affinity Capture-MS
BRE5 YNR051C Ubiquitin protease cofactor physical 1 1 1 Affinity Capture-MS
BRE5 YNR051C Ubiquitin protease cofactor genetic 1 1 1 Synthetic Growth Defect
HPR1 YDR138W Subunit of THO/TREX complexes physical 1 1 1 Affinity Capture-MS
SPT2 YER161C Protein involved in negative regulation of transcription physical 1 1 1 Affinity Capture-MS
SIR4 YDR227W SIR protein involved in assembly of silent chromatin domains physical 1 1 1 Affinity Capture-MS
MPT5 YGL178W mRNA-binding protein of the PUF family physical 1 1 1 Affinity Capture-RNA
MPT5 YGL178W mRNA-binding protein of the PUF family genetic 1 1 1 Negative Genetic
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
RTT106 YNL206C Histone chaperone physical 1 1 1 FRET
RLF2 YPR018W Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1) physical 1 1 1 FRET
KAR3 YPR141C Minus-end-directed microtubule motor genetic 1 1 1 Synthetic Lethality
CDC45 YLR103C DNA replication initiation factor genetic 1 1 1 Synthetic Lethality
DPB11 YJL090C DNA replication initiation protein genetic 1 1 1 Phenotypic Enhancement
RAD59 YDL059C Protein involved DNA double-strand break repair genetic 1 1 1 Phenotypic Enhancement
TAF2 YCR042C TFIID subunit (150 kDa) genetic 1 1 1 Dosage Rescue
TAF13 YML098W TFIID subunit (19 kDa) genetic 1 1 1 Dosage Rescue
ORC2 YBR060C Subunit of the origin recognition complex (ORC) genetic 1 1 1 Synthetic Lethality
LCD1 YDR499W Essential protein required for the DNA integrity checkpoint pathways genetic 1 1 1 Dosage Growth Defect
NPL6 YMR091C Component of the RSC chromatin remodeling complex genetic 1 1 1 Synthetic Growth Defect
SCS7 YMR272C Sphingolipid alpha-hydroxylase genetic 1 1 1 Phenotypic Enhancement
PZF1 YPR186C Transcription factor IIIA (TFIIIA) genetic 1 1 1 Negative Genetic
YPT6 YLR262C Rab family GTPase genetic 1 1 1 Negative Genetic
SRO9 YCL037C Cytoplasmic RNA-binding protein genetic 1 1 1 Negative Genetic
YOR338W YOR338W Putative protein of unknown function genetic 1 1 1 Phenotypic Suppression
RSC1 YGR056W Component of the RSC chromatin remodeling complex genetic 1 1 1 Phenotypic Suppression
MET18 YIL128W Component of cytosolic iron-sulfur protein assembly (CIA) machinery genetic 1 1 1 Phenotypic Suppression
DEG1 YFL001W tRNA:pseudouridine synthase genetic 1 1 1 Phenotypic Suppression
THP2 YHR167W Subunit of the THO and TREX complexes genetic 1 1 1 Negative Genetic
RGP1 YDR137W Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) genetic 1 1 1 Negative Genetic
GTR1 YML121W Subunit of a TORC1-stimulating GTPase and the EGO/GSE complex genetic 1 1 1 Negative Genetic
TOP3 YLR234W DNA Topoisomerase III genetic 1 1 1 Negative Genetic
RBH1 YJL181W Putative protein of unknown function genetic 1 1 1 Negative Genetic
LEO1 YOR123C Component of the Paf1 complex genetic 1 1 1 Negative Genetic
RXT2 YBR095C Component of the histone deacetylase Rpd3L complex genetic 1 1 1 Negative Genetic
SRB8 YCR081W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
PSY2 YNL201C Subunit of protein phosphatase PP4 complex genetic 1 1 1 Negative Genetic
VAM3 YOR106W Syntaxin-like vacuolar t-SNARE genetic 1 1 1 Negative Genetic
SUB1 YMR039C Transcriptional regulator genetic 1 1 1 Negative Genetic
ASK10 YGR097W Regulator of the Fps1p glycerol channel genetic 1 1 1 Negative Genetic
YPL113C YPL113C Glyoxylate reductase genetic 1 1 1 Positive Genetic
INO4 YOL108C Transcription factor involved in phospholipid synthesis genetic 1 1 1 Positive Genetic
PFD1 YJL179W Subunit of heterohexameric prefoldin genetic 1 1 1 Positive Genetic
YBL036C YBL036C Putative non-specific single-domain racemase genetic 1 1 1 Positive Genetic
SUR1 YPL057C Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit genetic 1 1 1 Positive Genetic
TOS2 YGR221C Protein involved in localization of Cdc24p to the site of bud growth genetic 1 1 1 Positive Genetic
SNT1 YCR033W Set3C histone deacetylase scaffold genetic 1 1 1 Positive Genetic
PEX22 YAL055W Putative peroxisomal membrane protein genetic 1 1 1 Positive Genetic
MUD1 YBR119W U1 snRNP A protein genetic 1 1 1 Positive Genetic
EDC2 YER035W RNA-binding protein that directly activates mRNA decapping genetic 1 1 1 Positive Genetic
DAL81 YIR023W Positive regulator of genes in multiple nitrogen degradation pathways genetic 1 1 1 Positive Genetic
GIM4 YEL003W Subunit of the heterohexameric cochaperone prefoldin complex genetic 1 1 1 Positive Genetic
BUD13 YGL174W Subunit of the RES complex genetic 1 1 1 Positive Genetic
SAP4 YGL229C Protein required for function of the Sit4p protein phosphatase genetic 1 1 1 Negative Genetic
THR1 YHR025W Homoserine kinase genetic 1 1 1 Positive Genetic
RKM3 YBR030W Ribosomal lysine methyltransferase genetic 1 1 1 Positive Genetic
CKS1 YBR135W Cyclin-dependent protein kinase regulatory subunit and adaptor genetic 1 1 1 Negative Genetic
BEM1 YBR200W Protein containing SH3-domains genetic 1 1 1 Negative Genetic
CDC55 YGL190C Regulatory subunit B of protein phosphatase 2A (PP2A) genetic 1 1 1 Negative Genetic
RRD1 YIL153W Peptidyl-prolyl cis/trans-isomerase genetic 1 1 1 Negative Genetic
FBP26 YJL155C Fructose-2,6-bisphosphatase, required for glucose metabolism genetic 1 1 1 Negative Genetic
TEP1 YNL128W PTEN homolog with no demonstrated inositol lipid phosphatase activity genetic 1 1 1 Negative Genetic
FIG4 YNL325C Phosphatidylinositol 3,5-bisphosphate (PtdIns[3,5]P) phosphatase genetic 1 1 1 Negative Genetic
SIZ1 YDR409W SUMO E3 ligase genetic 1 1 1 Synthetic Growth Defect
PKC1 YBL105C Protein serine/threonine kinase genetic 1 1 1 Positive Genetic
CDC37 YDR168W Essential Hsp90p co-chaperone genetic 1 1 1 Negative Genetic
UTR4 YEL038W Protein with sequence similarity to acireductone synthases genetic 1 1 1 Negative Genetic
TYS1 YGR185C Cytoplasmic tyrosyl-tRNA synthetase genetic 1 1 1 Negative Genetic
ERG11 YHR007C Lanosterol 14-alpha-demethylase genetic 1 1 1 Negative Genetic
CDC3 YLR314C Component of the septin ring that is required for cytokinesis genetic 1 1 1 Positive Genetic
RAD3 YER171W 5' to 3' DNA helicase genetic 1 1 1 Synthetic Growth Defect
TAF8 YML114C TFIID subunit (65 kDa) genetic 1 1 1 Negative Genetic
ULP1 YPL020C Protease that specifically cleaves Smt3p protein conjugates genetic 1 1 1 Negative Genetic
DBP5 YOR046C Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family genetic 1 1 1 Synthetic Lethality
PIF1 YML061C DNA helicase, potent G-quadruplex DNA binder/unwinder genetic 1 1 1 Dosage Growth Defect
DEP1 YAL013W Component of the Rpd3L histone deacetylase complex genetic 1 1 1 Synthetic Growth Defect
BRO1 YPL084W Cytoplasmic class E vacuolar protein sorting (VPS) factor genetic 1 1 1 Synthetic Growth Defect
KTR2 YKR061W Mannosyltransferase involved in N-linked protein glycosylation genetic 1 1 1 Synthetic Growth Defect
PHO80 YOL001W Cyclin genetic 1 1 1 Synthetic Growth Defect
RVS161 YCR009C Amphiphysin-like lipid raft protein genetic 1 1 1 Synthetic Growth Defect
SRB2 YHR041C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Synthetic Growth Defect
VPS33 YLR396C ATP-binding protein that is a subunit of the HOPS and CORVET complexes genetic 1 1 1 Synthetic Growth Defect
MDM12 YOL009C Mitochondrial outer membrane protein, ERMES complex subunit genetic 1 1 1 Synthetic Growth Defect
PEP3 YLR148W Component of CORVET membrane tethering complex genetic 1 1 1 Synthetic Growth Defect
PEP5 YMR231W Histone E3 ligase, component of CORVET membrane tethering complex genetic 1 1 1 Synthetic Growth Defect
VPS16 YPL045W Subunit of the HOPS and the CORVET complexes genetic 1 1 1 Synthetic Growth Defect
VPS25 YJR102C Component of the ESCRT-II complex genetic 1 1 1 Synthetic Growth Defect
VPS3 YDR495C Component of CORVET membrane tethering complex genetic 1 1 1 Synthetic Growth Defect
BUR2 YLR226W Cyclin for the Sgv1p (Bur1p) protein kinase genetic 1 1 1 Synthetic Lethality
CTK2 YJL006C Beta subunit of C-terminal domain kinase I (CTDK-I) genetic 1 1 1 Synthetic Lethality
DBF2 YGR092W Ser/Thr kinase involved in transcription and stress response genetic 1 1 1 Synthetic Lethality
HEM14 YER014W Protoporphyrinogen oxidase genetic 1 1 1 Synthetic Lethality
MGM1 YOR211C Mitochondrial GTPase, present in complex with Ugo1p and Fzo1p genetic 1 1 1 Synthetic Lethality
MSN5 YDR335W Karyopherin genetic 1 1 1 Synthetic Lethality
NUP133 YKR082W Subunit of Nup84p subcomplex of nuclear pore complex (NPC) genetic 1 1 1 Synthetic Lethality
PEP7 YDR323C Adaptor protein involved in vesicle-mediated vacuolar protein sorting genetic 1 1 1 Synthetic Lethality
PPA2 YMR267W Mitochondrial inorganic pyrophosphatase genetic 1 1 1 Synthetic Lethality
RSC2 YLR357W Component of the RSC chromatin remodeling complex genetic 1 1 1 Synthetic Lethality
RVS167 YDR388W Calmodulin-binding actin-associated protein genetic 1 1 1 Synthetic Lethality
SOV1 YMR066W Mitochondrial protein of unknown function genetic 1 1 1 Synthetic Lethality
UME6 YDR207C Rpd3L histone deacetylase complex subunit genetic 1 1 1 Synthetic Lethality
VPS34 YLR240W Phosphatidylinositol (PI) 3-kinase that synthesizes PI-3-phosphate genetic 1 1 1 Synthetic Lethality
MMS4 YBR098W Subunit of structure-specific Mms4p-Mus81p endonuclease genetic 1 1 1 Synthetic Growth Defect
VMA21 YGR105W Integral membrane protein required for V-ATPase function genetic 1 1 1 Synthetic Growth Defect
VOA1 YGR106C ER protein that functions in assembly of the V0 sector of V-ATPase genetic 1 1 1 Synthetic Growth Defect
DOT1 YDR440W Nucleosomal histone H3-Lys79 methylase genetic 1 1 1 Synthetic Rescue
VPS75 YNL246W NAP family histone chaperone genetic 1 1 1 Synthetic Growth Defect
MSG5 YNL053W Dual-specificity protein phosphatase genetic 1 1 1 Positive Genetic
PPZ2 YDR436W Serine/threonine protein phosphatase Z, isoform of Ppz1p genetic 1 1 1 Negative Genetic
KCS1 YDR017C Inositol hexakisphosphate and inositol heptakisphosphate kinase genetic 1 1 1 Negative Genetic
ELM1 YKL048C Serine/threonine protein kinase genetic 1 1 1 Negative Genetic
SNF5 YBR289W Subunit of the SWI/SNF chromatin remodeling complex genetic 1 1 1 Synthetic Growth Defect
EST1 YLR233C TLC1 RNA-associated factor involved in telomere length regulation genetic 1 1 1 Synthetic Growth Defect
SPT10 YJL127C Histone H3 acetylase with a role in transcriptional regulation genetic 1 1 1 Synthetic Lethality
TTI1 YKL033W Subunit of the ASTRA complex, involved in chromatin remodeling genetic 1 1 1 Positive Genetic
SWC3 YAL011W Protein of unknown function genetic 1 1 1 Phenotypic Enhancement
TOR1 YJR066W PIK-related protein kinase and rapamycin target genetic 1 1 1 Synthetic Growth Defect
SLX4 YLR135W Endonuclease involved in processing DNA genetic 1 1 1 Negative Genetic
RDH54 YBR073W DNA-dependent ATPase genetic 1 1 1 Synthetic Growth Defect
NUP53 YMR153W FG-nucleoporin component of central core of nuclear pore complex (NPC) genetic 1 1 1 Synthetic Growth Defect
RER2 YBR002C Forms the dehydrodolichyl diphosphate synthase (DDS) complex with NUS1 genetic 1 1 1 Positive Genetic
GUS1 YGL245W Glutamyl-tRNA synthetase (GluRS) genetic 1 1 1 Positive Genetic
MPE1 YKL059C Subunit of CPF cleavage and polyadenylation factor and E3 Ub-ligase genetic 1 1 1 Positive Genetic
DHR2 YKL078W Predominantly nucleolar DEAH-box ATP-dependent RNA helicase genetic 1 1 1 Positive Genetic
RPT1 YKL145W ATPase of the 19S regulatory particle of the 26S proteasome genetic 1 1 1 Positive Genetic
GAB1 YLR459W Subunit of the glycosylphosphatidylinositol transamidase complex genetic 1 1 1 Positive Genetic
MED11 YMR112C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Positive Genetic
SWI1 YPL016W Subunit of the SWI/SNF chromatin remodeling complex genetic 1 1 1 Positive Genetic
RPL19A YBR084C-A Ribosomal 60S subunit protein L19A genetic 1 1 1 Positive Genetic
IMG1 YCR046C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Positive Genetic
COX6 YHR051W Subunit VI of cytochrome c oxidase (Complex IV) genetic 1 1 1 Positive Genetic
PPE1 YHR075C Protein with carboxyl methyl esterase activity genetic 1 1 1 Positive Genetic
MRPL6 YHR147C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Positive Genetic
MRPL20 YKR085C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Positive Genetic
RPL40B YKR094C Ubiquitin-ribosomal 60S subunit protein L40B fusion protein genetic 1 1 1 Positive Genetic
BTS1 YPL069C Geranylgeranyl diphosphate synthase (GGPPS) genetic 1 1 1 Positive Genetic
VPS30 YPL120W Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II genetic 1 1 1 Positive Genetic
TRS20 YBR254C Core component of transport protein particle (TRAPP) complexes I-III genetic 1 1 1 Negative Genetic
RIB5 YBR256C Riboflavin synthase genetic 1 1 1 Negative Genetic
CDC10 YCR002C Component of the septin ring, required for cytokinesis genetic 1 1 1 Negative Genetic
UBC9 YDL064W SUMO-conjugating enzyme involved in the Smt3p conjugation pathway genetic 1 1 1 Negative Genetic
RPN6 YDL097C Essential, non-ATPase regulatory subunit of the 26S proteasome lid genetic 1 1 1 Negative Genetic
CDC9 YDL164C DNA ligase I found in nucleus and mitochondria genetic 1 1 1 Negative Genetic
PDS1 YDR113C Securin genetic 1 1 1 Negative Genetic
SEC1 YDR164C Sm-like protein involved in docking and fusion of exocytic vesicles genetic 1 1 1 Negative Genetic
UBC1 YDR177W Ubiquitin-conjugating enzyme genetic 1 1 1 Negative Genetic
CIA1 YDR267C Component of cytosolic iron-sulfur protein assembly (CIA) machinery genetic 1 1 1 Negative Genetic
GPI11 YDR302W ER membrane protein involved in a late step of GPI anchor assembly genetic 1 1 1 Negative Genetic
TFB1 YDR311W Subunit of TFIIH and nucleotide excision repair factor 3 complexes genetic 1 1 1 Negative Genetic
MMS21 YEL019C Highly conserved SUMO E3 ligase subunit of SMC5-SMC6 complex genetic 1 1 1 Negative Genetic
HYP2 YEL034W Translation elongation factor eIF-5A genetic 1 1 1 Negative Genetic
COG3 YER157W Essential component of the conserved oligomeric Golgi complex genetic 1 1 1 Negative Genetic
PAB1 YER165W Poly(A) binding protein genetic 1 1 1 Negative Genetic
SPB4 YFL002C Putative ATP-dependent RNA helicase genetic 1 1 1 Negative Genetic
MOB2 YFL034C-B Activator of Cbk1p kinase genetic 1 1 1 Negative Genetic
RPN11 YFR004W Metalloprotease subunit of 19S regulatory particle genetic 1 1 1 Negative Genetic
PRE4 YFR050C Beta 7 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
RPN12 YFR052W Subunit of the 19S regulatory particle of the 26S proteasome lid genetic 1 1 1 Negative Genetic
SCL1 YGL011C Alpha 1 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
RPT6 YGL048C ATPase of the 19S regulatory particle of the 26S proteasome genetic 1 1 1 Negative Genetic
NUP145 YGL092W Essential protein with distinct roles in two nuclear pore subcomplexes genetic 1 1 1 Negative Genetic
CEG1 YGL130W Guanylyltransferase involved in mRNA 5' capping genetic 1 1 1 Negative Genetic
BRR6 YGL247W Essential nuclear envelope integral membrane protein genetic 1 1 1 Negative Genetic
UTP8 YGR128C Nucleolar protein required for export of tRNAs from the nucleus genetic 1 1 1 Negative Genetic
PTI1 YGR156W Essential component of CPF (cleavage and polyadenylation factor) genetic 1 1 1 Negative Genetic
ORC6 YHR118C Subunit of the origin recognition complex (ORC) genetic 1 1 1 Negative Genetic
CFD1 YIL003W Highly conserved iron-sulfur cluster binding protein genetic 1 1 1 Negative Genetic
TAO3 YIL129C Component of the RAM signaling network genetic 1 1 1 Negative Genetic
SSL1 YLR005W Subunit of the core form of RNA polymerase transcription factor TFIIH genetic 1 1 1 Negative Genetic
RLP24 YLR009W Essential protein required for ribosomal large subunit biogenesis genetic 1 1 1 Negative Genetic
RSC58 YLR033W Component of the RSC chromatin remodeling complex genetic 1 1 1 Negative Genetic
FCF2 YLR051C Nucleolar protein involved in the early steps of 35S rRNA processing genetic 1 1 1 Negative Genetic
RRN5 YLR141W Protein involved in transcription of rDNA by RNA polymerase I genetic 1 1 1 Negative Genetic
KAP95 YLR347C Karyopherin beta genetic 1 1 1 Negative Genetic
TAP42 YMR028W Essential protein involved in the TOR signaling pathway genetic 1 1 1 Negative Genetic
PDS5 YMR076C Cohesion maintenance factor genetic 1 1 1 Negative Genetic
UTP15 YMR093W Nucleolar protein genetic 1 1 1 Negative Genetic
CEP3 YMR168C Essential kinetochore protein genetic 1 1 1 Negative Genetic
VTI1 YMR197C Protein involved in cis-Golgi membrane traffic genetic 1 1 1 Negative Genetic
RRN9 YMR270C Protein involved in promoting high level transcription of rDNA genetic 1 1 1 Negative Genetic
LST8 YNL006W Protein required for the transport of Gap1p genetic 1 1 1 Negative Genetic
TOP2 YNL088W Topoisomerase II genetic 1 1 1 Negative Genetic
INN1 YNL152W Essential protein that associates with contractile actomyosin ring genetic 1 1 1 Negative Genetic
PBR1 YNL181W Putative oxidoreductase genetic 1 1 1 Negative Genetic
RAP1 YNL216W Essential DNA-binding transcription regulator that binds many loci genetic 1 1 1 Negative Genetic
CSL4 YNL232W Exosome non-catalytic core component genetic 1 1 1 Negative Genetic
NAR1 YNL240C Subunit of the cytosolic iron-sulfur (FeS) protein assembly machinery genetic 1 1 1 Negative Genetic
CWC25 YNL245C Splicing factor required for the first step of pre-mRNA splicing genetic 1 1 1 Negative Genetic
RFA2 YNL312W Subunit of heterotrimeric Replication Protein A (RPA) genetic 1 1 1 Negative Genetic
RPB11 YOL005C RNA polymerase II subunit B12.5 genetic 1 1 1 Negative Genetic
SGT1 YOR057W Cochaperone protein genetic 1 1 1 Negative Genetic
RPT5 YOR117W ATPase of the 19S regulatory particle of the 26S proteasome genetic 1 1 1 Negative Genetic
RPB10 YOR210W RNA polymerase subunit ABC10-beta genetic 1 1 1 Negative Genetic
RPN8 YOR261C Essential non-ATPase regulatory subunit of the 26S proteasome genetic 1 1 1 Negative Genetic
YTM1 YOR272W Ribosomal assembly factor and 66S pre-ribosomal particle constituent genetic 1 1 1 Negative Genetic
NOP58 YOR310C Protein involved in producing mature rRNAs and snoRNAs genetic 1 1 1 Negative Genetic
PRE10 YOR362C Alpha 7 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
ERG10 YPL028W Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase) genetic 1 1 1 Negative Genetic
BMS1 YPL217C GTPase required for ribosomal subunit synthesis and rRNA processing genetic 1 1 1 Negative Genetic
SGV1 YPR161C Cyclin (Bur2p)-dependent protein kinase genetic 1 1 1 Negative Genetic
ORC4 YPR162C Subunit of the origin recognition complex (ORC) genetic 1 1 1 Negative Genetic
SAS3 YBL052C Histone acetyltransferase catalytic subunit of NuA3 complex genetic 1 1 1 Negative Genetic
ATG8 YBL078C Ub-like protein genetic 1 1 1 Negative Genetic
CSG2 YBR036C Endoplasmic reticulum membrane protein genetic 1 1 1 Negative Genetic
FAT1 YBR041W Very long chain fatty acyl-CoA synthetase and fatty acid transporter genetic 1 1 1 Negative Genetic
UBP14 YBR058C Ubiquitin-specific protease genetic 1 1 1 Negative Genetic
TEF2 YBR118W Translational elongation factor EF-1 alpha genetic 1 1 1 Negative Genetic
UMP1 YBR173C Chaperone required for correct maturation of the 20S proteasome genetic 1 1 1 Negative Genetic
DTR1 YBR180W Putative dityrosine transporter of the major facilitator superfamily genetic 1 1 1 Negative Genetic
MET8 YBR213W Bifunctional dehydrogenase and ferrochelatase genetic 1 1 1 Negative Genetic
YBP1 YBR216C Protein involved in cellular response to oxidative stress genetic 1 1 1 Negative Genetic
OM14 YBR230C Mitochondrial outer membrane receptor for cytosolic ribosomes genetic 1 1 1 Negative Genetic
RGD1 YBR260C GTPase-activating protein (RhoGAP) for Rho3p and Rho4p genetic 1 1 1 Negative Genetic
FRM2 YCL026C-A Type II nitroreductase, using NADH as reductant genetic 1 1 1 Negative Genetic
SPS22 YCL048W Protein of unknown function genetic 1 1 1 Negative Genetic
YDL124W YDL124W NADPH-dependent alpha-keto amide reductase genetic 1 1 1 Negative Genetic
RDI1 YDL135C Rho GDP dissociation inhibitor genetic 1 1 1 Negative Genetic
ENT1 YDL161W Epsin-like protein involved in endocytosis and actin patch assembly genetic 1 1 1 Negative Genetic
VMA1 YDL185W Subunit A of the V1 peripheral membrane domain of V-ATPase genetic 1 1 1 Negative Genetic
YDR003W-A YDR003W-A Putative protein of unknown function genetic 1 1 1 Negative Genetic
DOA4 YDR069C Ubiquitin hydrolase genetic 1 1 1 Negative Genetic
PEX7 YDR142C Peroxisomal signal receptor for peroxisomal matrix proteins genetic 1 1 1 Negative Genetic
SAN1 YDR143C Ubiquitin-protein ligase genetic 1 1 1 Negative Genetic
SWI5 YDR146C Transcription factor that recruits Mediator and Swi/Snf complexes genetic 1 1 1 Negative Genetic
SDH4 YDR178W Membrane anchor subunit of succinate dehydrogenase (SDH) genetic 1 1 1 Negative Genetic
BSC2 YDR275W Protein of unknown function involved in multidrug resistance genetic 1 1 1 Negative Genetic
RNH202 YDR279W Ribonuclease H2 subunit genetic 1 1 1 Negative Genetic
SSD1 YDR293C Translational repressor genetic 1 1 1 Negative Genetic
PPM1 YDR435C Carboxyl methyltransferase genetic 1 1 1 Negative Genetic
SSN2 YDR443C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
NHX1 YDR456W Na+/H+ and K+/H+ exchanger genetic 1 1 1 Negative Genetic
TOM1 YDR457W E3 ubiquitin ligase of the hect-domain class genetic 1 1 1 Negative Genetic
PAU10 YDR542W Protein of unknown function genetic 1 1 1 Negative Genetic
YND1 YER005W Apyrase with wide substrate specificity genetic 1 1 1 Negative Genetic
MXR1 YER042W Methionine-S-sulfoxide reductase genetic 1 1 1 Negative Genetic
YER085C YER085C Putative protein of unknown function genetic 1 1 1 Negative Genetic
UBP9 YER098W Ubiquitin-specific protease that cleaves ubiquitin-protein fusions genetic 1 1 1 Negative Genetic
GLE2 YER107C RNA export factor associated with the nuclear pore complex (NPC) genetic 1 1 1 Negative Genetic
YMR31 YFR049W Subunit of the mitochondrial alpha-ketoglutarate dehydrogenase genetic 1 1 1 Negative Genetic
HOS2 YGL194C Histone deacetylase and subunit of Set3 and Rpd3L complexes genetic 1 1 1 Negative Genetic
DOC1 YGL240W Processivity factor genetic 1 1 1 Negative Genetic
DPC29 YGR021W Putative mitochondrial protein of unknown function genetic 1 1 1 Negative Genetic
YGR035W-A YGR035W-A Putative protein of unknown function genetic 1 1 1 Negative Genetic
FMP48 YGR052W Putative protein of unknown function genetic 1 1 1 Negative Genetic
LST7 YGR057C Subunit of the Lst4p-Lst7p GTPase activating protein complex for Gtr2p genetic 1 1 1 Negative Genetic
CBP4 YGR174C Mitochondrial protein required for assembly of cytochrome bc1 complex genetic 1 1 1 Negative Genetic
SNG1 YGR197C Protein involved in resistance to nitrosoguanidine and 6-azauracil genetic 1 1 1 Negative Genetic
SER2 YGR208W Phosphoserine phosphatase of the phosphoglycerate pathway genetic 1 1 1 Negative Genetic
TRX2 YGR209C Cytoplasmic thioredoxin isoenzyme genetic 1 1 1 Negative Genetic
MPC3 YGR243W Highly conserved subunit of the mitochondrial pyruvate carrier (MPC) genetic 1 1 1 Negative Genetic
YGR273C YGR273C Putative protein of unknown function genetic 1 1 1 Negative Genetic
YHL026C YHL026C Putative protein of unknown function genetic 1 1 1 Negative Genetic
ROF1 YHR177W Putative transcription factor containing a WOPR domain genetic 1 1 1 Negative Genetic
DFG10 YIL049W Probable polyprenol reductase genetic 1 1 1 Negative Genetic
HUL4 YJR036C Protein with similarity to hect domain E3 ubiquitin-protein ligases genetic 1 1 1 Negative Genetic
YJR124C YJR124C Putative protein of unknown function genetic 1 1 1 Negative Genetic
BYE1 YKL005C Negative regulator of transcription elongation genetic 1 1 1 Negative Genetic
HOT13 YKL084W Zinc-binding mitochondrial intermembrane space (IMS) protein genetic 1 1 1 Negative Genetic
MBR1 YKL093W Protein involved in mitochondrial functions and stress response genetic 1 1 1 Negative Genetic
YJU3 YKL094W Monoglyceride lipase (MGL) that hydrolyzes fatty acid ethyl esters genetic 1 1 1 Negative Genetic
YKR018C YKR018C Protein of unknown function genetic 1 1 1 Negative Genetic
DYN1 YKR054C Cytoplasmic heavy chain dynein genetic 1 1 1 Negative Genetic
TRM2 YKR056W tRNA methyltransferase genetic 1 1 1 Negative Genetic
MLP1 YKR095W Myosin-like protein associated with the nuclear envelope genetic 1 1 1 Negative Genetic
EMC6 YLL014W Member of conserved ER transmembrane complex genetic 1 1 1 Negative Genetic
LDB18 YLL049W Component of the dynactin complex genetic 1 1 1 Negative Genetic
LOT6 YLR011W FMN-dependent NAD(P)H:quinone reductase genetic 1 1 1 Negative Genetic
RPS0B YLR048W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
SND2 YLR065C Protein involved in SRP-independent targeting of substrates to the ER genetic 1 1 1 Negative Genetic
ICT1 YLR099C Lysophosphatidic acid acyltransferase genetic 1 1 1 Negative Genetic
GID11 YLR149C Substrate receptor of the glucose-induced degradation-deficient (GID) genetic 1 1 1 Negative Genetic
STM1 YLR150W Protein required for optimal translation under nutrient stress genetic 1 1 1 Negative Genetic
YLR285C-A YLR285C-A Putative protein of unknown function genetic 1 1 1 Negative Genetic
CIS1 YLR346C Protein of unknown function found in mitochondria genetic 1 1 1 Negative Genetic
YLR415C YLR415C Putative protein of unknown function genetic 1 1 1 Negative Genetic
CRN1 YLR429W Coronin genetic 1 1 1 Negative Genetic
MRPL39 YML009C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
PPZ1 YML016C Serine/threonine protein phosphatase Z, isoform of Ppz2p genetic 1 1 1 Negative Genetic
SMA2 YML066C Meiosis-specific prospore membrane protein genetic 1 1 1 Negative Genetic
NUP188 YML103C Subunit of the inner ring of the nuclear pore complex (NPC) genetic 1 1 1 Negative Genetic
PML39 YML107C Protein required for nuclear retention of unspliced pre-mRNAs genetic 1 1 1 Negative Genetic
MSS1 YMR023C Mitochondrial protein genetic 1 1 1 Negative Genetic
SAM37 YMR060C Component of the Sorting and Assembly Machinery (SAM) complex genetic 1 1 1 Negative Genetic
NAT4 YMR069W N alpha-acetyl-transferase genetic 1 1 1 Negative Genetic
YMR090W YMR090W Putative protein of unknown function genetic 1 1 1 Negative Genetic
PGM2 YMR105C Phosphoglucomutase genetic 1 1 1 Negative Genetic
PSO2 YMR137C Nuclease required for DNA single- and double-strand break repair genetic 1 1 1 Negative Genetic
EAR1 YMR171C Specificity factor required for Rsp5p-dependent ubiquitination genetic 1 1 1 Negative Genetic
SCH9 YHR205W AGC family protein kinase genetic 1 1 1 Synthetic Growth Defect
GAD1 YMR250W Glutamate decarboxylase genetic 1 1 1 Negative Genetic
ELP6 YMR312W Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex genetic 1 1 1 Negative Genetic
ASI3 YNL008C Subunit of the inner nuclear membrane Asi ubiquitin ligase complex genetic 1 1 1 Negative Genetic
YNL033W YNL033W Putative protein of unknown function genetic 1 1 1 Negative Genetic
YNL040W YNL040W Protein of unknown function genetic 1 1 1 Negative Genetic
RNH201 YNL072W Ribonuclease H2 catalytic subunit genetic 1 1 1 Negative Genetic
SAL1 YNL083W ADP/ATP transporter genetic 1 1 1 Negative Genetic
MFA2 YNL145W Mating pheromone a-factor genetic 1 1 1 Negative Genetic
ASI2 YNL159C Subunit of the inner nuclear membrane Asi ubiquitin ligase complex genetic 1 1 1 Negative Genetic
SLA2 YNL243W Adaptor protein that links actin to clathrin and endocytosis genetic 1 1 1 Negative Genetic
TOF1 YNL273W Subunit of a replication-pausing checkpoint complex genetic 1 1 1 Negative Genetic
ERG24 YNL280C C-14 sterol reductase genetic 1 1 1 Negative Genetic
LRO1 YNR008W Acyltransferase that converts diacylglycerol to triacylglycerol (TGA) genetic 1 1 1 Negative Genetic
MCH4 YOL119C Protein with similarity to mammalian monocarboxylate permeases genetic 1 1 1 Negative Genetic
YOL159C-A YOL159C-A Protein of unknown function genetic 1 1 1 Negative Genetic
DFG16 YOR030W Probable multiple transmembrane protein genetic 1 1 1 Negative Genetic
EXO1 YOR033C 5'-3' exonuclease and flap-endonuclease genetic 1 1 1 Negative Genetic
SHE4 YOR035C Protein containing a UCS (UNC-45/CRO1/SHE4) domain genetic 1 1 1 Negative Genetic
PIN2 YOR104W Exomer-dependent cargo protein genetic 1 1 1 Negative Genetic
NFI1 YOR156C SUMO E3 ligase genetic 1 1 1 Negative Genetic
PEX27 YOR193W Peripheral peroxisomal membrane protein genetic 1 1 1 Negative Genetic
RIM20 YOR275C Protein involved in proteolytic activation of Rim101p genetic 1 1 1 Negative Genetic
RDL2 YOR286W Protein with rhodanese activity genetic 1 1 1 Negative Genetic
YOR296W YOR296W Putative protein of unknown function genetic 1 1 1 Negative Genetic
GNT1 YOR320C N-acetylglucosaminyltransferase genetic 1 1 1 Negative Genetic
YOR381W-A YOR381W-A Putative protein of unknown function genetic 1 1 1 Negative Genetic
SSN3 YPL042C Component of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
DIG1 YPL049C MAP kinase-responsive inhibitor of the Ste12p transcription factor genetic 1 1 1 Negative Genetic
RGL1 YPL066W Regulator of Rho1p signaling, cofactor of Tus1p genetic 1 1 1 Negative Genetic
RPS9A YPL081W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
ISU1 YPL135W Conserved protein of the mitochondrial matrix genetic 1 1 1 Negative Genetic
NIP100 YPL174C Large subunit of the dynactin complex genetic 1 1 1 Negative Genetic
YPL191C YPL191C K48-specific deubiquitinating (DUB) enzyme genetic 1 1 1 Negative Genetic
YPL225W YPL225W Protein of unknown function genetic 1 1 1 Negative Genetic
NTO1 YPR031W Subunit of the NuA3 histone acetyltransferase complex genetic 1 1 1 Negative Genetic
MCM16 YPR046W Component of the Ctf19 complex and the COMA subcomplex genetic 1 1 1 Negative Genetic
HDA3 YPR179C Subunit of HDA1 histone deacetylase complex genetic 1 1 1 Negative Genetic
HST4 YDR191W NAD(+)-dependent protein deacetylase genetic 1 1 1 Synthetic Rescue
HAP4 YKL109W Transcription factor genetic 1 1 1 Phenotypic Suppression
RTG1 YOL067C Transcription factor (bHLH) involved in interorganelle communication genetic 1 1 1 Phenotypic Suppression
MPC1 YGL080W Highly conserved subunit of mitochondrial pyruvate carrier (MPC) genetic 1 1 1 Phenotypic Suppression
CYT1 YOR065W Cytochrome c1 genetic 1 1 1 Phenotypic Suppression
SSN8 YNL025C Cyclin-like component of RNA polymerase II holoenzyme genetic 1 1 1 Negative Genetic
RAD14 YMR201C Subunit of Nucleotide Excision Repair Factor 1 (NEF1) genetic 1 1 1 Positive Genetic
SLT2 YHR030C Serine/threonine MAP kinase genetic 1 1 1 Negative Genetic
BLM10 YFL007W Proteasome activator genetic 1 1 1 Positive Genetic
RAD1 YPL022W Single-stranded DNA endonuclease (with Rad10p) genetic 1 1 1 Positive Genetic
TPM1 YNL079C Major isoform of tropomyosin genetic 1 1 1 Positive Genetic
IFM1 YOL023W Mitochondrial translation initiation factor 2 genetic 1 1 1 Positive Genetic
STH1 YIL126W ATPase component of the RSC chromatin remodeling complex genetic 1 1 1 Synthetic Lethality
SWD1 YAR003W Subunit of the COMPASS (Set1C) complex genetic 1 1 1 Negative Genetic
CDC7 YDL017W S/T kinase and catalytic subunit of DDK (Dbf4-dependent kinase) genetic 1 1 1 Negative Genetic
CDC23 YHR166C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 1 1 1 Negative Genetic
HSL1 YKL101W Nim1p-related protein kinase genetic 1 1 1 Negative Genetic
CCC1 YLR220W Vacuolar Fe2+/Mn2+ transporter genetic 1 1 1 Negative Genetic
EAF7 YNL136W Subunit of the NuA4 histone acetyltransferase complex genetic 1 1 1 Negative Genetic
REC8 YPR007C Meiosis-specific component of the sister chromatid cohesion complex genetic 1 1 1 Negative Genetic
NCA2 YPR155C Protein that regulates expression of Fo-F1 ATP synthase subunits genetic 1 1 1 Negative Genetic
HSE1 YHL002W Subunit of the endosomal Vps27p-Hse1p complex genetic 1 1 1 Negative Genetic
PAN1 YIR006C Part of actin cytoskeleton-regulatory complex Pan1p-Sla1p-End3p genetic 1 1 1 Positive Genetic
CST9 YLR394W SUMO E3 ligase genetic 1 1 1 Positive Genetic
KRE1 YNL322C Cell wall glycoprotein involved in beta-glucan assembly genetic 1 1 1 Positive Genetic
YJR084W YJR084W Protein that forms a complex with Thp3p genetic 1 1 1 Negative Genetic
ULA1 YPL003W Protein that activates Rub1p (NEDD8) before neddylation genetic 1 1 1 Negative Genetic
UFO1 YML088W F-box receptor protein genetic 1 1 1 Negative Genetic
UBX3 YDL091C Clathrin-coated vesicle component, regulator of endocytosis genetic 1 1 1 Negative Genetic
CDC60 YPL160W Cytosolic leucyl tRNA synthetase genetic 1 1 1 Negative Genetic
GPH1 YPR160W Glycogen phosphorylase required for the mobilization of glycogen genetic 1 1 1 Negative Genetic
SEC27 YGL137W Essential beta'-coat protein of the COPI coatomer genetic 1 1 1 Negative Genetic
GET4 YOR164C Protein involved in inserting tail-anchored proteins into ER membranes genetic 1 1 1 Negative Genetic
PMA1 YGL008C Plasma membrane P2-type H+-ATPase genetic 1 1 1 Negative Genetic
ASC1 YMR116C G-protein beta subunit and guanine dissociation inhibitor for Gpa2p genetic 1 1 1 Negative Genetic
ADA2 YDR448W Transcription coactivator physical 1 1 1 Affinity Capture-MS
ACE2 YLR131C Transcription factor required for septum destruction after cytokinesis genetic 1 1 1 Negative Genetic
AHC1 YOR023C Subunit of the Ada histone acetyltransferase complex genetic 1 1 1 Negative Genetic
ADH6 YMR318C NADPH-dependent medium chain alcohol dehydrogenase genetic 1 1 1 Negative Genetic
AFG3 YER017C Mitochondrial inner membrane m-AAA protease component genetic 1 1 1 Positive Genetic
ARP1 YHR129C Actin-related protein of the dynactin complex genetic 1 1 1 Synthetic Lethality
ACF2 YLR144C Intracellular beta-1,3-endoglucanase genetic 1 1 1 Negative Genetic
AIM45 YPR004C Putative ortholog of mammalian ETF-alpha genetic 1 1 1 Negative Genetic
ANT1 YPR128C Peroxisomal adenine nucleotide transporter genetic 1 1 1 Negative Genetic
ARO2 YGL148W Bifunctional chorismate synthase and flavin reductase genetic 1 1 1 Negative Genetic
APJ1 YNL077W Hsp40 chaperone with a role in SUMO-mediated protein degradation physical 1 1 1 Affinity Capture-MS
AGP1 YCL025C Broad-specificity, low-affinity amino acid permease genetic 1 1 1 Negative Genetic
AIM10 YER087W Protein with similarity to tRNA synthetases genetic 1 1 1 Synthetic Lethality