Standard name Systematic name Name description Description
DMC1 YER179W Meiosis-specific recombinase required for double-strand break repair Meiosis-specific recombinase required for double-strand break repair; also required for pairing between homologous chromosomes and for the normal morphogenesis of synaptonemal complex; binds ssDNA and dsDNA, forms helical filaments; potent inhibitor of the ATPase activity of Srs2p helicase, blocking its ssDNA translocating motor activity and inhibiting its antirecombinase activity; stimulated by Rdh54p; homolog of Rad51p and the bacterial RecA protein
Visualize the interactome of DMC1
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
no data no data no data

GFP localization & abundance

GFP localization GFP abundance
no data no data

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
DMC1 0 6 0 0 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
SPO11 YHL022C Meiosis-specific protein required for meiotic recombination genetic 10 4 7 Phenotypic Enhancement, Phenotypic Suppression, Phenotypic Suppression, Phenotypic Suppression, Synthetic Growth Defect, Synthetic Rescue, Phenotypic Suppression, Phenotypic Enhancement, Phenotypic Suppression, Phenotypic Suppression
PCH2 YBR186W Hexameric ring ATPase that remodels chromosome axis protein Hop1p genetic 9 4 6 Synthetic Rescue, Phenotypic Suppression, Phenotypic Suppression, Synthetic Growth Defect, Synthetic Rescue, Phenotypic Enhancement, Phenotypic Suppression, Phenotypic Suppression, Phenotypic Suppression
DMC1 YER179W Meiosis-specific recombinase required for double-strand break repair physical 8 3 7 Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Co-crystal Structure, Reconstituted Complex, Two-hybrid
HED1 YDR014W-A Meiosis-specific protein genetic 6 3 5 Synthetic Rescue, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Suppression, Phenotypic Enhancement, Phenotypic Suppression
RAD54 YGL163C DNA-dependent ATPase that stimulates strand exchange genetic 5 4 5 Dosage Rescue, Synthetic Rescue, Phenotypic Enhancement, Phenotypic Suppression, Phenotypic Enhancement
RAD17 YOR368W Checkpoint protein genetic 5 3 5 Synthetic Rescue, Synthetic Rescue, Phenotypic Suppression, Phenotypic Suppression, Phenotypic Enhancement
RAD51 YER095W Strand exchange protein genetic 5 3 4 Dosage Rescue, Phenotypic Enhancement, Dosage Rescue, Phenotypic Suppression, Phenotypic Enhancement
MEK1 YOR351C Meiosis-specific serine/threonine protein kinase genetic 5 3 4 Synthetic Rescue, Phenotypic Suppression, Phenotypic Enhancement, Phenotypic Suppression, Phenotypic Suppression
NDT80 YHR124W Meiosis-specific transcription factor genetic 4 4 4 Dosage Rescue, Synthetic Rescue, Phenotypic Enhancement, Phenotypic Suppression
RDH54 YBR073W DNA-dependent ATPase physical 4 2 4 Two-hybrid, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex
RAD54 YGL163C DNA-dependent ATPase that stimulates strand exchange physical 4 1 4 Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex
HOP1 YIL072W Meiosis-specific protein required for chromosome synapsis genetic 4 3 3 Synthetic Rescue, Phenotypic Suppression, Phenotypic Suppression, Synthetic Lethality
RED1 YLR263W Protein component of the synaptonemal complex axial elements genetic 3 3 3 Synthetic Rescue, Synthetic Lethality, Phenotypic Suppression
RAD51 YER095W Strand exchange protein physical 3 2 3 Reconstituted Complex, Reconstituted Complex, Two-hybrid
MEI5 YPL121C Meiosis-specific protein involved in meiotic recombination physical 3 3 2 Affinity Capture-Western, Two-hybrid, Reconstituted Complex
RFA2 YNL312W Subunit of heterotrimeric Replication Protein A (RPA) physical 3 2 2 Reconstituted Complex, Affinity Capture-Western, Reconstituted Complex
LCD1 YDR499W Essential protein required for the DNA integrity checkpoint pathways genetic 3 3 1 Phenotypic Suppression, Synthetic Growth Defect, Synthetic Lethality
ACC1 YNR016C Acetyl-CoA carboxylase, biotin containing enzyme physical 2 2 2 Affinity Capture-MS, Two-hybrid
MEC1 YBR136W Genome integrity checkpoint protein and PI kinase superfamily member genetic 2 2 2 Synthetic Rescue, Phenotypic Suppression
REC114 YMR133W Protein involved in early stages of meiotic recombination genetic 2 2 2 Dosage Rescue, Phenotypic Suppression
DOT1 YDR440W Nucleosomal histone H3-Lys79 methylase genetic 2 2 2 Synthetic Rescue, Phenotypic Suppression
FPR3 YML074C Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase) genetic 2 2 2 Phenotypic Enhancement, Phenotypic Suppression
SAE3 YHR079C-A Meiosis-specific protein involved in meiotic recombination physical 2 1 2 Reconstituted Complex, Reconstituted Complex
SIC1 YLR079W Cyclin-dependent kinase inhibitor (CKI) genetic 2 1 2 Phenotypic Suppression, Phenotypic Suppression
ECM2 YBR065C Pre-mRNA splicing factor genetic 2 1 2 Negative Genetic, Negative Genetic
MEI5 YPL121C Meiosis-specific protein involved in meiotic recombination genetic 2 2 1 Phenotypic Enhancement, Phenotypic Suppression
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SPT10 YJL127C Histone H3 acetylase with a role in transcriptional regulation regulation 1 1 1 DNA to cDNA expression microarray evidence
UME6 YDR207C Rpd3L histone deacetylase complex subunit regulation 1 1 1 chromatin immunoprecipitation-chip evidence
APC2 YLR127C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) physical 1 1 1 Two-hybrid
APL6 YGR261C Beta3-like subunit of the yeast AP-3 complex genetic 1 1 1 Negative Genetic
DEP1 YAL013W Component of the Rpd3L histone deacetylase complex genetic 1 1 1 Positive Genetic
CDC5 YMR001C Polo-like kinase required for mitotic exit genetic 1 1 1 Dosage Rescue
POR1 YNL055C Mitochondrial porin (voltage-dependent anion channel) physical 1 1 1 Affinity Capture-MS
RVB2 YPL235W ATP-dependent DNA helicase, also known as reptin physical 1 1 1 Affinity Capture-MS
NOP14 YDL148C Nucleolar protein physical 1 1 1 Affinity Capture-MS
TRP3 YKL211C Indole-3-glycerol-phosphate synthase physical 1 1 1 Affinity Capture-MS
DPM1 YPR183W Dolichol phosphate mannose (Dol-P-Man) synthase of ER membrane physical 1 1 1 Affinity Capture-MS
MDJ1 YFL016C Co-chaperone that stimulates HSP70 protein Ssc1p ATPase activity physical 1 1 1 Affinity Capture-MS
TEM1 YML064C GTPase involved in initiation of Mitotic Exit Network (MEN) physical 1 1 1 Two-hybrid
SLM1 YIL105C Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm2p physical 1 1 1 Two-hybrid
RDH54 YBR073W DNA-dependent ATPase genetic 1 1 1 Phenotypic Enhancement
SWI5 YDR146C Transcription factor that recruits Mediator and Swi/Snf complexes physical 1 1 1 Two-hybrid
NDC80 YIL144W Component of the kinetochore-associated Ndc80 complex physical 1 1 1 Two-hybrid
PDC1 YLR044C Major of three pyruvate decarboxylase isozymes physical 1 1 1 Two-hybrid
PET309 YLR067C Specific translational activator for the COX1 mRNA physical 1 1 1 Two-hybrid
PDC5 YLR134W Minor isoform of pyruvate decarboxylase physical 1 1 1 Two-hybrid
ULS1 YOR191W Swi2/Snf2-related translocase, SUMO-Targeted Ubiquitin Ligase (STUbL) physical 1 1 1 Two-hybrid
MRE11 YMR224C Nuclease subunit of the MRX complex with Rad50p and Xrs2p physical 1 1 1 Affinity Capture-MS
HEK2 YBL032W RNA binding protein involved in asymmetric localization of ASH1 mRNA physical 1 1 1 Affinity Capture-RNA
SAE3 YHR079C-A Meiosis-specific protein involved in meiotic recombination genetic 1 1 1 Phenotypic Suppression
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-RNA
REC8 YPR007C Meiosis-specific component of the sister chromatid cohesion complex physical 1 1 1 Affinity Capture-MS
REC8 YPR007C Meiosis-specific component of the sister chromatid cohesion complex genetic 1 1 1 Phenotypic Enhancement
MPS3 YJL019W Nuclear envelope protein physical 1 1 1 Affinity Capture-MS
XRN1 YGL173C Evolutionarily-conserved 5'-3' exonuclease genetic 1 1 1 Phenotypic Enhancement
SPO13 YHR014W Meiotic regulator genetic 1 1 1 Synthetic Lethality
HOP2 YGL033W Meiosis-specific protein that localizes to chromosomes genetic 1 1 1 Synthetic Rescue
RAD24 YER173W Checkpoint protein genetic 1 1 1 Synthetic Rescue
ZIP1 YDR285W Transverse filament protein of the synaptonemal complex genetic 1 1 1 Phenotypic Enhancement
RFA1 YAR007C Subunit of heterotrimeric Replication Protein A (RPA) genetic 1 1 1 Negative Genetic
POL30 YBR088C Proliferating cell nuclear antigen (PCNA) genetic 1 1 1 Negative Genetic
RAD52 YML032C Protein involved in homologous recombination genetic 1 1 1 Phenotypic Enhancement
QCR8 YJL166W Subunit 8 of ubiquinol cytochrome-c reductase (Complex III) genetic 1 1 1 Negative Genetic
RHO2 YNL090W Non-essential small GTPase of the Rho/Rac family of Ras-like proteins genetic 1 1 1 Negative Genetic
SUM1 YDR310C Transcriptional repressor that regulates middle-sporulation genes genetic 1 1 1 Phenotypic Enhancement
XRS2 YDR369C FHA domain-containing component of the Mre11 complex genetic 1 1 1 Phenotypic Enhancement
PPH3 YDR075W Catalytic subunit of protein phosphatase PP4 complex genetic 1 1 1 Negative Genetic
RAD53 YPL153C DNA damage response kinase genetic 1 1 1 Phenotypic Suppression
RRM3 YHR031C DNA helicase involved in rDNA replication and Ty1 transposition genetic 1 1 1 Positive Genetic
ROF1 YHR177W Putative transcription factor containing a WOPR domain genetic 1 1 1 Positive Genetic
RRP43 YCR035C Exosome non-catalytic core component genetic 1 1 1 Negative Genetic
TFA2 YKR062W TFIIE small subunit genetic 1 1 1 Negative Genetic
PBR1 YNL181W Putative oxidoreductase genetic 1 1 1 Negative Genetic
NAR1 YNL240C Subunit of the cytosolic iron-sulfur (FeS) protein assembly machinery genetic 1 1 1 Negative Genetic
MIN6 YBL039W-B Mitochondrial protein of unknown function genetic 1 1 1 Negative Genetic
PYC2 YBR218C Pyruvate carboxylase isoform genetic 1 1 1 Negative Genetic
IMG1 YCR046C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
SLX5 YDL013W Subunit of the Slx5-Slx8 SUMO-targeted Ub ligase (STUbL) complex genetic 1 1 1 Negative Genetic
YNL140C YNL140C Protein of unknown function genetic 1 1 1 Negative Genetic
RTG1 YOL067C Transcription factor (bHLH) involved in interorganelle communication genetic 1 1 1 Negative Genetic
RTC1 YOL138C Subunit of SEACAT, a subcomplex of the SEA complex genetic 1 1 1 Negative Genetic
GUP2 YPL189W Probable membrane protein genetic 1 1 1 Negative Genetic
PPT1 YGR123C Protein serine/threonine phosphatase genetic 1 1 1 Negative Genetic
HTA1 YDR225W Histone H2A genetic 1 1 1 Phenotypic Suppression
HTA2 YBL003C Histone H2A genetic 1 1 1 Phenotypic Suppression
SLD3 YGL113W Protein involved in the initiation of DNA replication genetic 1 1 1 Phenotypic Suppression
TSA1 YML028W Thioredoxin peroxidase genetic 1 1 1 Synthetic Growth Defect
MRP49 YKL167C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
SLA2 YNL243W Adaptor protein that links actin to clathrin and endocytosis genetic 1 1 1 Negative Genetic
MDM32 YOR147W Mitochondrial inner membrane protein with similarity to Mdm31p genetic 1 1 1 Negative Genetic
SUV3 YPL029W ATP-dependent RNA helicase genetic 1 1 1 Negative Genetic
PMA1 YGL008C Plasma membrane P2-type H+-ATPase genetic 1 1 1 Negative Genetic
RTF1 YGL244W Subunit of RNAPII-associated chromatin remodeling Paf1 complex genetic 1 1 1 Phenotypic Suppression
CLB1 YGR108W B-type cyclin involved in cell cycle progression genetic 1 1 1 Dosage Rescue
DBF4 YDR052C Regulatory subunit of Cdc7p-Dbf4p kinase complex genetic 1 1 1 Phenotypic Suppression
BET4 YJL031C Alpha subunit of Type II geranylgeranyltransferase genetic 1 1 1 Negative Genetic
COQ10 YOL008W Coenzyme Q (ubiquinone) binding protein genetic 1 1 1 Negative Genetic
COQ11 YLR290C Putative oxidoreductase, subunit of Coenzyme Q biosynthetic complexes genetic 1 1 1 Negative Genetic
DDR48 YMR173W DNA damage-responsive protein genetic 1 1 1 Negative Genetic