Standard name Systematic name Name description Description
EST1 YLR233C TLC1 RNA-associated factor involved in telomere length regulation TLC1 RNA-associated factor involved in telomere length regulation; recruitment subunit of telomerase; has G-quadruplex promoting activity required for telomere elongation; role in activating telomere-bound Est2p-TLC1-RNA; EST1 has a paralog, EBS1, that arose from the whole genome duplication
Visualize the interactome of EST1
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)
G2/M 138

CYCLoPs localization & abundance

WT1 WT2 WT3
no data no data no data

GFP localization & abundance

GFP localization GFP abundance
no data no data

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
EST1 7 0 0 0 0

Enzyme information

Catalyzed reactions in Yeast8

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
YKU70 YMR284W Subunit of the telomeric Ku complex (Yku70p-Yku80p) genetic 14 6 12 Dosage Rescue, Dosage Rescue, Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Synthetic Lethality, Synthetic Rescue, Synthetic Growth Defect, Negative Genetic, Phenotypic Suppression, Negative Genetic, Negative Genetic
YKU80 YMR106C Subunit of telomeric Ku complex (Yku70p-Yku80p) genetic 12 7 9 Dosage Rescue, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Synthetic Lethality, Synthetic Rescue, Synthetic Growth Defect, Phenotypic Suppression, Phenotypic Suppression, Phenotypic Enhancement, Negative Genetic, Negative Genetic
CDC13 YDL220C Single stranded DNA-binding protein found at TG1-3 telomere G-tails physical 10 3 7 Affinity Capture-Western, Affinity Capture-Western, Two-hybrid, Affinity Capture-Western, Affinity Capture-Western, Two-hybrid, Reconstituted Complex, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western
EST2 YLR318W Reverse transcriptase subunit of the telomerase holoenzyme physical 7 2 7 Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western
EST2 YLR318W Reverse transcriptase subunit of the telomerase holoenzyme genetic 6 4 5 Phenotypic Suppression, Phenotypic Suppression, Synthetic Rescue, Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Growth Defect
RAD52 YML032C Protein involved in homologous recombination genetic 5 3 5 Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
CDC13 YDL220C Single stranded DNA-binding protein found at TG1-3 telomere G-tails genetic 4 4 4 Dosage Rescue, Synthetic Growth Defect, Phenotypic Suppression, Negative Genetic
YCR016W YCR016W Putative protein of unknown function genetic 4 2 3 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic
SDS3 YIL084C Component of the Rpd3L histone deacetylase complex genetic 4 2 3 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic
EST3 YIL009C-A Component of the telomerase holoenzyme physical 3 3 3 Reconstituted Complex, Affinity Capture-MS, Affinity Capture-Western
RAD51 YER095W Strand exchange protein genetic 3 3 3 Synthetic Lethality, Synthetic Growth Defect, Negative Genetic
YKU80 YMR106C Subunit of telomeric Ku complex (Yku70p-Yku80p) physical 3 2 3 Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western
RPS21B YJL136C Protein component of the small (40S) ribosomal subunit genetic 3 2 3 Negative Genetic, Positive Genetic, Negative Genetic
THI3 YDL080C Regulatory protein that binds Pdc2p and Thi2p transcription factors genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
OCA2 YNL056W Protein of unknown function genetic 3 2 2 Negative Genetic, Negative Genetic, Synthetic Growth Defect
VPS35 YJL154C Endosomal subunit of membrane-associated retromer complex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
YJU3 YKL094W Monoglyceride lipase (MGL) that hydrolyzes fatty acid ethyl esters genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
BRE2 YLR015W Subunit of COMPASS (Set1C) complex genetic 2 2 2 Synthetic Growth Defect, Positive Genetic
CAF120 YNL278W Part of the CCR4-NOT transcriptional regulatory complex genetic 2 2 2 Synthetic Growth Defect, Positive Genetic
MPS3 YJL019W Nuclear envelope protein physical 2 2 2 Two-hybrid, Reconstituted Complex
SME1 YOR159C Core Sm protein Sm E physical 2 2 2 Affinity Capture-Western, Affinity Capture-MS
POP6 YGR030C Subunit of RNase MRP, nuclear RNase P and telomerase physical 2 2 2 Affinity Capture-Western, Affinity Capture-MS
NAP1 YKR048C Histone chaperone and assembly chaperone for Rps6a/b genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
SIR2 YDL042C Conserved NAD+ dependent histone deacetylase of the Sirtuin family genetic 2 2 2 Synthetic Rescue, Synthetic Growth Defect
TEX1 YNL253W Protein involved in mRNA export genetic 2 2 2 Negative Genetic, Positive Genetic
SCS7 YMR272C Sphingolipid alpha-hydroxylase genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
YPT52 YKR014C Endosomal Rab family GTPase genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
OCA1 YNL099C Putative protein tyrosine phosphatase genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
MSB4 YOL112W GTPase-activating protein of the Ras superfamily genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
EXO1 YOR033C 5'-3' exonuclease and flap-endonuclease genetic 2 2 2 Synthetic Rescue, Synthetic Growth Defect
TIM18 YOR297C Component of the mitochondrial TIM22 complex genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
SPE1 YKL184W Ornithine decarboxylase genetic 2 2 2 Synthetic Growth Defect, Positive Genetic
GSH1 YJL101C Gamma glutamylcysteine synthetase genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
SNF4 YGL115W Activating gamma subunit of the AMP-activated Snf1p kinase complex genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
UBP3 YER151C Ubiquitin-specific protease that cleaves Ub-protein fusions genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
UBP6 YFR010W Ubiquitin-specific protease genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
VPS1 YKR001C Dynamin-like GTPase required for vacuolar sorting genetic 2 2 2 Synthetic Growth Defect, Positive Genetic
YGR237C YGR237C Putative protein of unknown function genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
RPL19A YBR084C-A Ribosomal 60S subunit protein L19A genetic 2 2 2 Synthetic Growth Defect, Positive Genetic
RPL31B YLR406C Ribosomal 60S subunit protein L31B genetic 2 2 2 Synthetic Growth Defect, Positive Genetic
SDH5 YOL071W Protein required for flavinylation of Sdh1p genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
RPS14A YCR031C Protein component of the small (40S) ribosomal subunit genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
LGE1 YPL055C Protein involved in histone H2B ubiquitination genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
RPL29 YFR032C-A Ribosomal 60S subunit protein L29 genetic 2 2 2 Synthetic Growth Defect, Positive Genetic
RPL35B YDL136W Ribosomal 60S subunit protein L35B genetic 2 2 2 Synthetic Growth Defect, Positive Genetic
YDL180W YDL180W Putative protein of unknown function genetic 2 2 2 Synthetic Growth Defect, Positive Genetic
KTI12 YKL110C Protein that plays a role in modification of tRNA wobble nucleosides genetic 2 2 2 Synthetic Growth Defect, Positive Genetic
PTK2 YJR059W Serine/threonine protein kinase genetic 2 2 2 Synthetic Growth Defect, Positive Genetic
SHE9 YDR393W Protein required for normal mitochondrial morphology genetic 2 2 2 Synthetic Growth Defect, Positive Genetic
PEX14 YGL153W Central component of the peroxisomal importomer complex genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
YBR285W YBR285W Putative protein of unknown function genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
RIM21 YNL294C pH sensor molecule, component of the RIM101 pathway genetic 2 2 2 Synthetic Growth Defect, Positive Genetic
GOS1 YHL031C v-SNARE protein involved in Golgi transport genetic 2 2 2 Synthetic Growth Defect, Positive Genetic
HOM6 YJR139C Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase) genetic 2 2 2 Synthetic Growth Defect, Positive Genetic
BRE5 YNR051C Ubiquitin protease cofactor genetic 2 2 2 Synthetic Growth Defect, Positive Genetic
ATG15 YCR068W Phospholipase genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
AGP1 YCL025C Broad-specificity, low-affinity amino acid permease genetic 2 2 2 Synthetic Growth Defect, Positive Genetic
DNM1 YLL001W Dynamin-related GTPase involved in mitochondrial organization genetic 2 1 2 Negative Genetic, Negative Genetic
EGD2 YHR193C Alpha subunit of the nascent polypeptide-associated complex (NAC) genetic 2 1 2 Synthetic Growth Defect, Synthetic Growth Defect
RPF2 YKR081C Essential protein involved in rRNA maturation and ribosomal assembly physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
RAD50 YNL250W Subunit of MRX complex with Mre11p and Xrs2p genetic 2 1 2 Synthetic Growth Defect, Synthetic Growth Defect
RAP1 YNL216W Essential DNA-binding transcription regulator that binds many loci genetic 2 1 2 Negative Genetic, Negative Genetic
MSH4 YFL003C Protein involved in meiotic recombination genetic 2 1 2 Negative Genetic, Negative Genetic
LSM6 YDR378C Lsm (Like Sm) protein genetic 2 1 2 Negative Genetic, Negative Genetic
TIF2 YJL138C Translation initiation factor eIF4A genetic 2 1 2 Negative Genetic, Negative Genetic
RAD10 YML095C Single-stranded DNA endonuclease (with Rad1p) genetic 2 1 2 Negative Genetic, Negative Genetic
TAZ1 YPR140W Lyso-phosphatidylcholine acyltransferase genetic 2 1 2 Negative Genetic, Negative Genetic
AVT6 YER119C Vacuolar aspartate and glutamate exporter genetic 2 1 2 Negative Genetic, Negative Genetic
ELF1 YKL160W Transcription elongation factor with a conserved zinc finger domain genetic 2 1 2 Negative Genetic, Negative Genetic
CDC48 YDL126C AAA ATPase with protein-unfoldase activity physical 2 2 1 Affinity Capture-Western, Affinity Capture-MS
GLC7 YER133W Type 1 S/T protein phosphatase (PP1) catalytic subunit genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
FKH1 YIL131C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SUM1 YDR310C Transcriptional repressor that regulates middle-sporulation genes regulation 1 1 1 DNA to cDNA expression microarray evidence
FKH2 YNL068C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MSN2 YMR037C Stress-responsive transcriptional activator regulation 1 1 1 chromatin immunoprecipitation-chip evidence
YAP6 YDR259C Basic leucine zipper (bZIP) transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CDC73 YLR418C Component of the Paf1p complex genetic 1 1 1 Synthetic Growth Defect
CBF5 YLR175W Pseudouridine synthase catalytic subunit of box H/ACA snoRNPs physical 1 1 1 Affinity Capture-MS
CKB1 YGL019W Beta regulatory subunit of casein kinase 2 (CK2) genetic 1 1 1 Synthetic Growth Defect
CKB2 YOR039W Beta' regulatory subunit of casein kinase 2 (CK2) physical 1 1 1 Affinity Capture-MS
ENP2 YGR145W Component of the SSU physical 1 1 1 Affinity Capture-MS
BRR2 YER172C RNA-dependent ATPase RNA helicase (DEIH box) physical 1 1 1 Affinity Capture-MS
BRE1 YDL074C E3 ubiquitin ligase genetic 1 1 1 Synthetic Growth Defect
ARC1 YGL105W Protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases genetic 1 1 1 Negative Genetic
BMH1 YER177W 14-3-3 protein, major isoform genetic 1 1 1 Synthetic Growth Defect
DBP7 YKR024C Putative ATP-dependent RNA helicase of the DEAD-box family physical 1 1 1 Affinity Capture-MS
ALB1 YJL122W Shuttling pre-60S factor physical 1 1 1 Affinity Capture-MS
CBC2 YPL178W Small subunit of the heterodimeric cap binding complex with Sto1p genetic 1 1 1 Positive Genetic
ARP7 YPR034W Component of both the SWI/SNF and RSC chromatin remodeling complexes genetic 1 1 1 Negative Genetic
DST1 YGL043W General transcription elongation factor TFIIS genetic 1 1 1 Synthetic Growth Defect
ACT1 YFL039C Actin, structural protein in cytoskeleton genetic 1 1 1 Negative Genetic
AAH1 YNL141W Adenine deaminase (adenine aminohydrolase) genetic 1 1 1 Synthetic Growth Defect
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
APC1 YNL172W Largest subunit of the Anaphase-Promoting Complex/Cyclosome physical 1 1 1 Affinity Capture-MS
APC1 YNL172W Largest subunit of the Anaphase-Promoting Complex/Cyclosome genetic 1 1 1 Negative Genetic
ARO1 YDR127W Pentafunctional arom protein genetic 1 1 1 Synthetic Growth Defect
ASF1 YJL115W Nucleosome assembly factor genetic 1 1 1 Synthetic Growth Defect
BEM2 YER155C Rho GTPase activating protein (RhoGAP) genetic 1 1 1 Synthetic Growth Defect
CDC24 YAL041W Guanine nucleotide exchange factor (GEF) for Cdc42p genetic 1 1 1 Negative Genetic
ATP11 YNL315C Molecular chaperone genetic 1 1 1 Synthetic Growth Defect
CLP1 YOR250C Component of the cleavage and polyadenylation factor I (CF I) genetic 1 1 1 Positive Genetic
CTF18 YMR078C Subunit of a complex with Ctf8p genetic 1 1 1 Synthetic Growth Defect
DOA1 YKL213C WD-repeat protein involved in ubiquitin-mediated protein degradation genetic 1 1 1 Synthetic Growth Defect
ELP2 YGR200C Subunit of Elongator complex genetic 1 1 1 Synthetic Growth Defect
ERP1 YAR002C-A Member of the p24 family involved in ER to Golgi transport genetic 1 1 1 Negative Genetic
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator genetic 1 1 1 Synthetic Growth Defect
AEP2 YMR282C Mitochondrial protein genetic 1 1 1 Synthetic Growth Defect
ECM29 YHL030W Scaffold protein physical 1 1 1 Affinity Capture-MS
DIB1 YPR082C 17-kDa component of the U4/U6aU5 tri-snRNP genetic 1 1 1 Negative Genetic
CSE2 YNR010W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Synthetic Growth Defect
ARP8 YOR141C Nuclear actin-related protein involved in chromatin remodeling genetic 1 1 1 Phenotypic Enhancement
DEP1 YAL013W Component of the Rpd3L histone deacetylase complex genetic 1 1 1 Synthetic Growth Defect
BGL2 YGR282C Endo-beta-1,3-glucanase genetic 1 1 1 Synthetic Growth Defect
BRR1 YPR057W snRNP protein component of spliceosomal snRNPs genetic 1 1 1 Synthetic Growth Defect
CCT6 YDR188W Subunit of the cytosolic chaperonin Cct ring complex genetic 1 1 1 Positive Genetic
ATG9 YDL149W Transmembrane protein involved in forming Cvt and autophagic vesicles genetic 1 1 1 Synthetic Growth Defect
DRS2 YAL026C Trans-golgi network aminophospholipid translocase (flippase) genetic 1 1 1 Synthetic Growth Defect
ACH1 YBL015W Protein with CoA transferase activity genetic 1 1 1 Positive Genetic
ARF1 YDL192W ADP-ribosylation factor genetic 1 1 1 Positive Genetic
BUD13 YGL174W Subunit of the RES complex genetic 1 1 1 Synthetic Growth Defect
DLD3 YEL071W 2-hydroxyglutarate transhydrogenase, and minor D-lactate dehydrogenase genetic 1 1 1 Negative Genetic
ELM1 YKL048C Serine/threonine protein kinase genetic 1 1 1 Synthetic Growth Defect
CAT5 YOR125C Protein required for ubiquinone (Coenzyme Q) biosynthesis genetic 1 1 1 Synthetic Growth Defect
ART10 YLR392C Protein of unknown function that contains 2 PY motifs genetic 1 1 1 Synthetic Growth Defect
BUL1 YMR275C Alpha-arrestin, component of the Rsp5p E3-ubiquitin ligase complex genetic 1 1 1 Positive Genetic
MSS116 YDR194C Mitochondrial transcription elongation factor physical 1 1 1 Affinity Capture-MS
PUF6 YDR496C Pumilio-homology domain protein physical 1 1 1 Affinity Capture-MS
PUF6 YDR496C Pumilio-homology domain protein genetic 1 1 1 Synthetic Growth Defect
KRE33 YNL132W Acetyltransferase required for biogenesis of small ribosomal subunit physical 1 1 1 Affinity Capture-MS
PWP1 YLR196W Protein with WD-40 repeats involved in rRNA processing physical 1 1 1 Affinity Capture-MS
MRX1 YER077C Protein that associates with mitochondrial ribosome physical 1 1 1 Affinity Capture-MS
URB1 YKL014C Protein required for the normal accumulation of 25S and 5.8S rRNAs physical 1 1 1 Affinity Capture-MS
PDI1 YCL043C Protein disulfide isomerase physical 1 1 1 Affinity Capture-MS
RRP12 YPL012W Protein required for export of the ribosomal subunits physical 1 1 1 Affinity Capture-MS
HSH49 YOR319W U2-snRNP associated splicing factor physical 1 1 1 Affinity Capture-MS
UTP10 YJL109C Nucleolar protein physical 1 1 1 Affinity Capture-MS
MRM1 YOR201C Ribose methyltransferase physical 1 1 1 Affinity Capture-MS
RRP1 YDR087C Essential evolutionarily conserved nucleolar protein physical 1 1 1 Affinity Capture-MS
SSK1 YLR006C Cytoplasmic phosphorelay intermediate osmosensor and regulator physical 1 1 1 Affinity Capture-MS
MCM6 YGL201C Protein involved in DNA replication physical 1 1 1 Two-hybrid
SPT23 YKL020C ER membrane protein involved in regulation of OLE1 transcription physical 1 1 1 Two-hybrid
URE2 YNL229C Nitrogen catabolite repression transcriptional regulator physical 1 1 1 Two-hybrid
FRT2 YAL028W Tail-anchored ER membrane protein of unknown function physical 1 1 1 Two-hybrid
MPS3 YJL019W Nuclear envelope protein genetic 1 1 1 Synthetic Growth Defect
YMD8 YML038C Putative nucleotide sugar transporter physical 1 1 1 Two-hybrid
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-RNA
EST3 YIL009C-A Component of the telomerase holoenzyme genetic 1 1 1 Phenotypic Enhancement
RFA1 YAR007C Subunit of heterotrimeric Replication Protein A (RPA) physical 1 1 1 Reconstituted Complex
ISW1 YBR245C ATPase subunit of imitation-switch (ISWI) class chromatin remodelers physical 1 1 1 Affinity Capture-RNA
NSA1 YGL111W Constituent of 66S pre-ribosomal particles physical 1 1 1 Affinity Capture-MS
UTP22 YGR090W Component of the small-subunit processome physical 1 1 1 Affinity Capture-MS
TIF1 YKR059W Translation initiation factor eIF4A physical 1 1 1 Affinity Capture-MS
TIF1 YKR059W Translation initiation factor eIF4A genetic 1 1 1 Synthetic Growth Defect
NCS6 YGL211W Protein required for uridine thiolation of Gln, Lys, and Glu tRNAs physical 1 1 1 Affinity Capture-MS
NCS6 YGL211W Protein required for uridine thiolation of Gln, Lys, and Glu tRNAs genetic 1 1 1 Synthetic Growth Defect
EST1 YLR233C TLC1 RNA-associated factor involved in telomere length regulation physical 1 1 1 Affinity Capture-MS
POP1 YNL221C Subunit of RNase MRP, nuclear RNase P and telomerase complexes physical 1 1 1 Affinity Capture-MS
TOM1 YDR457W E3 ubiquitin ligase of the hect-domain class physical 1 1 1 Affinity Capture-MS
YKU70 YMR284W Subunit of the telomeric Ku complex (Yku70p-Yku80p) physical 1 1 1 Affinity Capture-MS
STI1 YOR027W Evolutionarily-conserved Hsp90 cochaperone physical 1 1 1 Affinity Capture-MS
SMB1 YER029C Core Sm protein Sm B physical 1 1 1 Affinity Capture-MS
UFD4 YKL010C Ubiquitin-protein ligase (E3) physical 1 1 1 Affinity Capture-MS
GUD1 YDL238C Guanine deaminase physical 1 1 1 Affinity Capture-MS
KAP123 YER110C Karyopherin beta physical 1 1 1 Affinity Capture-MS
RPN2 YIL075C Subunit of the 26S proteasome physical 1 1 1 Affinity Capture-MS
SMD1 YGR074W Core Sm protein Sm D1 physical 1 1 1 Affinity Capture-MS
RPN1 YHR027C Non-ATPase base subunit of the 19S RP of the 26S proteasome physical 1 1 1 Affinity Capture-MS
UBR1 YGR184C E3 ubiquitin ligase (N-recognin) physical 1 1 1 Affinity Capture-MS
SHP1 YBL058W UBX domain-containing substrate adaptor for Cdc48p physical 1 1 1 Affinity Capture-MS
NPL4 YBR170C Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase physical 1 1 1 Affinity Capture-MS
NPL4 YBR170C Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase genetic 1 1 1 Synthetic Growth Defect
NAP1 YKR048C Histone chaperone and assembly chaperone for Rps6a/b physical 1 1 1 Affinity Capture-MS
SMD2 YLR275W Core Sm protein Sm D2 physical 1 1 1 Affinity Capture-MS
SMD3 YLR147C Core Sm protein Sm D3 physical 1 1 1 Affinity Capture-MS
UBX2 YML013W Bridging factor involved in ER-associated protein degradation (ERAD) physical 1 1 1 Affinity Capture-MS
UBX2 YML013W Bridging factor involved in ER-associated protein degradation (ERAD) genetic 1 1 1 Synthetic Growth Defect
UFD1 YGR048W Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase physical 1 1 1 Affinity Capture-MS
UBP15 YMR304W Ubiquitin-specific protease involved in protein deubiquitination physical 1 1 1 Affinity Capture-MS
RPT5 YOR117W ATPase of the 19S regulatory particle of the 26S proteasome physical 1 1 1 Affinity Capture-MS
RPN5 YDL147W Subunit of the CSN and 26S proteasome lid complexes physical 1 1 1 Affinity Capture-MS
YNR065C YNR065C Protein of unknown function physical 1 1 1 Affinity Capture-MS
RPT4 YOR259C ATPase of the 19S regulatory particle of the 26S proteasome physical 1 1 1 Affinity Capture-MS
RKR1 YMR247C RING domain E3 ubiquitin ligase physical 1 1 1 Affinity Capture-MS
NMD5 YJR132W Karyopherin physical 1 1 1 Affinity Capture-MS
SGD1 YLR336C Essential nuclear protein physical 1 1 1 Affinity Capture-MS
SPB1 YCL054W AdoMet-dependent methyltransferase physical 1 1 1 Affinity Capture-MS
SMX3 YPR182W Core Sm protein Sm F physical 1 1 1 Affinity Capture-MS
SMX3 YPR182W Core Sm protein Sm F genetic 1 1 1 Negative Genetic
RPT1 YKL145W ATPase of the 19S regulatory particle of the 26S proteasome physical 1 1 1 Affinity Capture-MS
PAA1 YDR071C Polyamine acetyltransferase physical 1 1 1 Affinity Capture-MS
PAA1 YDR071C Polyamine acetyltransferase genetic 1 1 1 Synthetic Growth Defect
VTH1 YIL173W Putative membrane glycoprotein physical 1 1 1 Affinity Capture-MS
VTH1 YIL173W Putative membrane glycoprotein genetic 1 1 1 Synthetic Growth Defect
PRE3 YJL001W Beta 1 subunit of the 20S proteasome physical 1 1 1 Affinity Capture-MS
VPS74 YDR372C Golgi PI4K effector, PtdIns4P sensor, and retention receptor physical 1 1 1 Affinity Capture-MS
PRE5 YMR314W Alpha 6 subunit of the 20S proteasome physical 1 1 1 Affinity Capture-MS
HSP42 YDR171W Small heat shock protein (sHSP) with chaperone activity physical 1 1 1 Affinity Capture-MS
RPT3 YDR394W ATPase of the 19S regulatory particle of the 26S proteasome physical 1 1 1 Affinity Capture-MS
MRPL20 YKR085C Mitochondrial ribosomal protein of the large subunit physical 1 1 1 Affinity Capture-MS
SSN2 YDR443C Subunit of the RNA polymerase II mediator complex physical 1 1 1 Affinity Capture-MS
POP7 YBR167C Subunit of RNase MRP, nuclear RNase P and telomerase physical 1 1 1 Affinity Capture-MS
PRE10 YOR362C Alpha 7 subunit of the 20S proteasome physical 1 1 1 Affinity Capture-MS
RPT2 YDL007W ATPase of the 19S regulatory particle of the 26S proteasome physical 1 1 1 Affinity Capture-MS
PEP1 YBL017C Type I transmembrane sorting receptor for multiple vacuolar hydrolases physical 1 1 1 Affinity Capture-MS
RPN6 YDL097C Essential, non-ATPase regulatory subunit of the 26S proteasome lid physical 1 1 1 Affinity Capture-MS
SCL1 YGL011C Alpha 1 subunit of the 20S proteasome physical 1 1 1 Affinity Capture-MS
EUC1 YMR111C Sequence-specific DNA binding protein physical 1 1 1 Affinity Capture-MS
HIS3 YOR202W Imidazoleglycerol-phosphate dehydratase physical 1 1 1 Affinity Capture-MS
ISA1 YLL027W Protein required for maturation of mitochondrial [4Fe-4S] proteins physical 1 1 1 Affinity Capture-MS
HSP26 YBR072W Small heat shock protein (sHSP) with chaperone activity physical 1 1 1 Affinity Capture-MS
RPN9 YDR427W Non-ATPase regulatory subunit of the 26S proteasome physical 1 1 1 Affinity Capture-MS
MTR3 YGR158C Exosome non-catalytic core component physical 1 1 1 Affinity Capture-MS
MRPL25 YGR076C Mitochondrial ribosomal protein of the large subunit physical 1 1 1 Affinity Capture-MS
PRE6 YOL038W Alpha 4 subunit of the 20S proteasome physical 1 1 1 Affinity Capture-MS
RPN13 YLR421C Subunit of the 19S regulatory particle of the 26S proteasome lid physical 1 1 1 Affinity Capture-MS
PRE8 YML092C Alpha 2 subunit of the 20S proteasome physical 1 1 1 Affinity Capture-MS
SKA1 YKL023W SKI complex-associated protein physical 1 1 1 Affinity Capture-MS
PTC3 YBL056W Type 2C protein phosphatase (PP2C) physical 1 1 1 Affinity Capture-MS
LCB5 YLR260W Minor sphingoid long-chain base kinase physical 1 1 1 Affinity Capture-MS
SIR4 YDR227W SIR protein involved in assembly of silent chromatin domains physical 1 1 1 Affinity Capture-MS
SIR4 YDR227W SIR protein involved in assembly of silent chromatin domains genetic 1 1 1 Synthetic Rescue
RPN11 YFR004W Metalloprotease subunit of 19S regulatory particle physical 1 1 1 Affinity Capture-MS
RPN3 YER021W Essential non-ATPase regulatory subunit of the 26S proteasome lid physical 1 1 1 Affinity Capture-MS
SPO14 YKR031C Phospholipase D physical 1 1 1 Affinity Capture-MS
MRPL10 YNL284C Mitochondrial ribosomal protein of the large subunit physical 1 1 1 Affinity Capture-MS
RPN7 YPR108W Essential non-ATPase regulatory subunit of the 26S proteasome physical 1 1 1 Affinity Capture-MS
MED7 YOL135C Subunit of the RNA polymerase II mediator complex physical 1 1 1 Affinity Capture-MS
SMX2 YFL017W-A Core Sm protein Sm G physical 1 1 1 Affinity Capture-MS
SWC4 YGR002C Component of the Swr1p complex that incorporates Htz1p into chromatin physical 1 1 1 Affinity Capture-MS
SKI6 YGR195W Exosome non-catalytic core component physical 1 1 1 Affinity Capture-MS
TUS1 YLR425W Guanine nucleotide exchange factor (GEF) that modulates Rho1p activity physical 1 1 1 Affinity Capture-MS
MRPL31 YKL138C Mitochondrial ribosomal protein of the large subunit physical 1 1 1 Affinity Capture-MS
PRE2 YPR103W Beta 5 subunit of the 20S proteasome physical 1 1 1 Affinity Capture-MS
NOP53 YPL146C Nucleolar protein physical 1 1 1 Affinity Capture-MS
LRO1 YNR008W Acyltransferase that converts diacylglycerol to triacylglycerol (TGA) physical 1 1 1 Affinity Capture-MS
PAP2 YOL115W Non-canonical poly(A) polymerase physical 1 1 1 Affinity Capture-MS
PAP2 YOL115W Non-canonical poly(A) polymerase genetic 1 1 1 Synthetic Growth Defect
RRP46 YGR095C Exosome non-catalytic core component physical 1 1 1 Affinity Capture-MS
MRPL27 YBR282W Mitochondrial ribosomal protein of the large subunit physical 1 1 1 Affinity Capture-MS
HSP82 YPL240C Hsp90 chaperone physical 1 1 1 Affinity Capture-MS
HSP82 YPL240C Hsp90 chaperone genetic 1 1 1 Synthetic Growth Defect
SSE2 YBR169C Member of Hsp110 subclass of the heat shock protein 70 (HSP70) family physical 1 1 1 Affinity Capture-MS
YDJ1 YNL064C Type I HSP40 co-chaperone physical 1 1 1 Affinity Capture-MS
MRPL9 YGR220C Mitochondrial ribosomal protein of the large subunit physical 1 1 1 Affinity Capture-MS
VPS13 YLL040C Lipid transport protein involved in prospore membrane morphogenesis physical 1 1 1 Affinity Capture-MS
GCN2 YDR283C Protein kinase physical 1 1 1 Affinity Capture-MS
MRP20 YDR405W Mitochondrial ribosomal protein of the large subunit physical 1 1 1 Affinity Capture-MS
RAD50 YNL250W Subunit of MRX complex with Mre11p and Xrs2p physical 1 1 1 Affinity Capture-MS
GAT1 YFL021W Transcriptional activator of nitrogen catabolite repression genes physical 1 1 1 Affinity Capture-MS
NCS2 YNL119W Protein required for uridine thiolation of Lys(UUU) and Glu(UUC) tRNAs physical 1 1 1 Affinity Capture-MS
NCS2 YNL119W Protein required for uridine thiolation of Lys(UUU) and Glu(UUC) tRNAs genetic 1 1 1 Synthetic Growth Defect
HSL1 YKL101W Nim1p-related protein kinase physical 1 1 1 Affinity Capture-MS
HSL1 YKL101W Nim1p-related protein kinase genetic 1 1 1 Synthetic Growth Defect
PRE7 YBL041W Beta 6 subunit of the 20S proteasome physical 1 1 1 Affinity Capture-MS
MEC3 YLR288C DNA damage and meiotic pachytene checkpoint protein physical 1 1 1 Affinity Capture-MS
HRP1 YOL123W Subunit of cleavage factor I physical 1 1 1 Affinity Capture-MS
TUB1 YML085C Alpha-tubulin physical 1 1 1 Affinity Capture-MS
MLP1 YKR095W Myosin-like protein associated with the nuclear envelope physical 1 1 1 Affinity Capture-MS
SIR1 YKR101W Protein involved in silencing at mating-type loci HML and HMR genetic 1 1 1 Synthetic Rescue
SIR3 YLR442C Silencing protein genetic 1 1 1 Synthetic Rescue
NMD2 YHR077C Protein involved in the nonsense-mediated mRNA decay (NMD) pathway genetic 1 1 1 Synthetic Rescue
RSC6 YCR052W Component of the RSC chromatin remodeling complex genetic 1 1 1 Phenotypic Suppression
RSC2 YLR357W Component of the RSC chromatin remodeling complex genetic 1 1 1 Negative Genetic
HO YDL227C Site-specific endonuclease genetic 1 1 1 Negative Genetic
TOF1 YNL273W Subunit of a replication-pausing checkpoint complex genetic 1 1 1 Negative Genetic
MIP1 YOR330C Mitochondrial DNA polymerase gamma genetic 1 1 1 Positive Genetic
MOT2 YER068W Ubiquitin-protein ligase subunit of the CCR4-NOT complex genetic 1 1 1 Synthetic Lethality
JNM1 YMR294W Component of the yeast dynactin complex genetic 1 1 1 Synthetic Lethality
HSC82 YMR186W Cytoplasmic chaperone of the Hsp90 family genetic 1 1 1 Synthetic Growth Defect
MBA1 YBR185C Membrane-associated mitochondrial ribosome receptor genetic 1 1 1 Negative Genetic
THI6 YPL214C Thiamine-phosphate diphosphorylase and hydroxyethylthiazole kinase genetic 1 1 1 Negative Genetic
YPR089W YPR089W Protein of unknown function genetic 1 1 1 Negative Genetic
YKE2 YLR200W Subunit of the heterohexameric Gim/prefoldin protein complex genetic 1 1 1 Synthetic Growth Defect
TEL1 YBL088C Protein kinase primarily involved in telomere length regulation genetic 1 1 1 Phenotypic Suppression
MDM31 YHR194W Mitochondrial protein that may have a role in phospholipid metabolism genetic 1 1 1 Synthetic Growth Defect
MDM35 YKL053C-A Mitochondrial intermembrane space protein genetic 1 1 1 Synthetic Growth Defect
PAC10 YGR078C Part of the heteromeric co-chaperone GimC/prefoldin complex genetic 1 1 1 Synthetic Growth Defect
SLC1 YDL052C 1-acyl-sn-glycerol-3-phosphate acyltransferase genetic 1 1 1 Synthetic Growth Defect
SWS2 YNL081C Putative mitochondrial ribosomal protein of the small subunit genetic 1 1 1 Synthetic Growth Defect
TIR3 YIL011W Cell wall mannoprotein genetic 1 1 1 Synthetic Growth Defect
RQT4 YKR023W Subunit of ribosome-associated quality control trigger complex (RQT) genetic 1 1 1 Synthetic Growth Defect
STE20 YHL007C Cdc42p-activated signal transducing kinase genetic 1 1 1 Synthetic Growth Defect
SRO9 YCL037C Cytoplasmic RNA-binding protein genetic 1 1 1 Synthetic Growth Defect
YME1 YPR024W Catalytic subunit of i-AAA protease complex genetic 1 1 1 Synthetic Growth Defect
GPR1 YDL035C Plasma membrane G protein coupled receptor (GPCR) genetic 1 1 1 Synthetic Growth Defect
TPS2 YDR074W Phosphatase subunit of the trehalose-6-P synthase/phosphatase complex genetic 1 1 1 Synthetic Growth Defect
PMR1 YGL167C High affinity Ca2+/Mn2+ P-type ATPase genetic 1 1 1 Synthetic Growth Defect
SST2 YLR452C GTPase-activating protein for Gpa1p genetic 1 1 1 Synthetic Growth Defect
WHI3 YNL197C RNA binding protein that modulates mRNA stability genetic 1 1 1 Synthetic Growth Defect
MRPL36 YBR122C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Synthetic Growth Defect
MRM2 YGL136C Mitochondrial 2' O-ribose methyltransferase genetic 1 1 1 Synthetic Growth Defect
PAN6 YIL145C Pantothenate synthase genetic 1 1 1 Synthetic Growth Defect
VPS41 YDR080W Subunit of the HOPS endocytic tethering complex genetic 1 1 1 Synthetic Growth Defect
FYV4 YHR059W Protein of unknown function genetic 1 1 1 Synthetic Growth Defect
RAD55 YDR076W Protein that stimulates strand exchange genetic 1 1 1 Synthetic Growth Defect
HPM1 YIL110W AdoMet-dependent methyltransferase genetic 1 1 1 Synthetic Growth Defect
IMD3 YLR432W Inosine monophosphate dehydrogenase genetic 1 1 1 Synthetic Growth Defect
SND2 YLR065C Protein involved in SRP-independent targeting of substrates to the ER genetic 1 1 1 Synthetic Growth Defect
GIM4 YEL003W Subunit of the heterohexameric cochaperone prefoldin complex genetic 1 1 1 Synthetic Growth Defect
INP52 YNL106C Polyphosphatidylinositol phosphatase genetic 1 1 1 Synthetic Growth Defect
VIP1 YLR410W Bifunctional inositol pyrophosphate kinase and phosphatase genetic 1 1 1 Synthetic Growth Defect
HMI1 YOL095C Mitochondrial inner membrane localized ATP-dependent DNA helicase genetic 1 1 1 Synthetic Growth Defect
XRS2 YDR369C FHA domain-containing component of the Mre11 complex genetic 1 1 1 Synthetic Growth Defect
RPS16A YMR143W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Synthetic Growth Defect
MEH1 YKR007W Subunit of the EGO/GSE complex genetic 1 1 1 Synthetic Growth Defect
VAM7 YGL212W Vacuolar SNARE protein genetic 1 1 1 Synthetic Growth Defect
STB5 YHR178W Transcription factor genetic 1 1 1 Synthetic Growth Defect
VPS27 YNR006W Endosomal protein that forms a complex with Hse1p genetic 1 1 1 Synthetic Growth Defect
GET2 YER083C Subunit of the GET complex genetic 1 1 1 Synthetic Growth Defect
OST4 YDL232W Subunit of the oligosaccharyltransferase complex of the ER lumen genetic 1 1 1 Synthetic Growth Defect
GTR1 YML121W Subunit of a TORC1-stimulating GTPase and the EGO/GSE complex genetic 1 1 1 Synthetic Growth Defect
LST4 YKL176C Subunit of the Lst4p-Lst7p GTPase activating protein complex for Gtr2p genetic 1 1 1 Synthetic Growth Defect
OAR1 YKL055C Mitochondrial 3-oxoacyl-[acyl-carrier-protein] reductase genetic 1 1 1 Synthetic Growth Defect
RIM8 YGL045W Protein involved in proteolytic activation of Rim101p genetic 1 1 1 Synthetic Growth Defect
SSD1 YDR293C Translational repressor genetic 1 1 1 Synthetic Growth Defect
KEL1 YHR158C Protein required for proper cell fusion and cell morphology genetic 1 1 1 Synthetic Growth Defect
RAD57 YDR004W Protein that stimulates strand exchange genetic 1 1 1 Synthetic Growth Defect
YHM2 YMR241W Citrate and oxoglutarate carrier protein genetic 1 1 1 Synthetic Growth Defect
SNX4 YJL036W Sorting nexin genetic 1 1 1 Synthetic Growth Defect
RRD1 YIL153W Peptidyl-prolyl cis/trans-isomerase genetic 1 1 1 Synthetic Growth Defect
IMP21 YIL154C Transcriptional activator involved in maintenance of ion homeostasis genetic 1 1 1 Synthetic Growth Defect
RAD54 YGL163C DNA-dependent ATPase that stimulates strand exchange genetic 1 1 1 Synthetic Growth Defect
YUH1 YJR099W Ubiquitin C-terminal hydrolase genetic 1 1 1 Synthetic Growth Defect
HUR1 YGL168W Protein with a role in DNA repair genetic 1 1 1 Synthetic Growth Defect
TMA19 YKL056C Protein that associates with ribosomes genetic 1 1 1 Synthetic Growth Defect
RPL26B YGR034W Ribosomal 60S subunit protein L26B genetic 1 1 1 Synthetic Growth Defect
YTA7 YGR270W Chromatin-binding ATPase that regulates histone gene expression genetic 1 1 1 Synthetic Growth Defect
PRE9 YGR135W Alpha 3 subunit of the 20S proteasome genetic 1 1 1 Synthetic Growth Defect
RIM13 YMR154C Calpain-like cysteine protease genetic 1 1 1 Synthetic Growth Defect
YKR045C YKR045C Putative protein of unknown function genetic 1 1 1 Synthetic Growth Defect
POL32 YJR043C Third subunit of DNA polymerase delta genetic 1 1 1 Synthetic Growth Defect
PET8 YNL003C S-adenosylmethionine transporter of the mitochondrial inner membrane genetic 1 1 1 Synthetic Growth Defect
ZWF1 YNL241C Glucose-6-phosphate dehydrogenase (G6PD) genetic 1 1 1 Synthetic Growth Defect
MRE11 YMR224C Nuclease subunit of the MRX complex with Rad50p and Xrs2p genetic 1 1 1 Synthetic Growth Defect
INO4 YOL108C Transcription factor involved in phospholipid synthesis genetic 1 1 1 Synthetic Growth Defect
RPN10 YHR200W Proteasome polyubiquitin receptor genetic 1 1 1 Synthetic Growth Defect
XPT1 YJR133W Xanthine-guanine phosphoribosyl transferase genetic 1 1 1 Synthetic Growth Defect
RPL43B YJR094W-A Ribosomal 60S subunit protein L43B genetic 1 1 1 Synthetic Growth Defect
IES5 YER092W Non-essential INO80 chromatin remodeling complex subunit genetic 1 1 1 Synthetic Growth Defect
GAS1 YMR307W Beta-1,3-glucanosyltransferase required for cell wall assembly genetic 1 1 1 Synthetic Growth Defect
YJR084W YJR084W Protein that forms a complex with Thp3p genetic 1 1 1 Synthetic Growth Defect
RTT109 YLL002W Histone acetyltransferase genetic 1 1 1 Synthetic Growth Defect
MYO5 YMR109W One of two type I myosin motors genetic 1 1 1 Synthetic Growth Defect
RTS3 YGR161C Putative component of the protein phosphatase type 2A complex genetic 1 1 1 Synthetic Growth Defect
YLR407W YLR407W Putative protein of unknown function genetic 1 1 1 Synthetic Growth Defect
GSF2 YML048W Endoplasmic reticulum (ER) localized integral membrane protein genetic 1 1 1 Synthetic Growth Defect
FRE2 YKL220C Ferric reductase and cupric reductase genetic 1 1 1 Synthetic Growth Defect
VPS75 YNL246W NAP family histone chaperone genetic 1 1 1 Synthetic Growth Defect
PKP2 YGL059W Mitochondrial protein kinase genetic 1 1 1 Synthetic Growth Defect
PHO90 YJL198W Low-affinity phosphate transporter genetic 1 1 1 Synthetic Growth Defect
SIC1 YLR079W Cyclin-dependent kinase inhibitor (CKI) genetic 1 1 1 Synthetic Growth Defect
FAR11 YNL127W Protein involved in recovery from cell cycle arrest genetic 1 1 1 Synthetic Growth Defect
HDA1 YNL021W Catalytic subunit of class II HDA1 histone deacetylase complex genetic 1 1 1 Synthetic Growth Defect
PUB1 YNL016W Poly (A)+ RNA-binding protein genetic 1 1 1 Synthetic Growth Defect
PIR3 YKL163W O-glycosylated covalently-bound cell wall protein genetic 1 1 1 Synthetic Growth Defect
RAD5 YLR032W DNA helicase/Ubiquitin ligase genetic 1 1 1 Synthetic Growth Defect
MYO3 YKL129C One of two type I myosins genetic 1 1 1 Synthetic Growth Defect
PEX5 YDR244W Peroxisomal membrane signal receptor for peroxisomal matrix proteins genetic 1 1 1 Synthetic Growth Defect
SMI1 YGR229C Protein involved in the regulation of cell wall synthesis genetic 1 1 1 Synthetic Growth Defect
SSP1 YHR184W Protein involved in the control of meiotic nuclear division genetic 1 1 1 Synthetic Growth Defect
OAF3 YKR064W Putative transcriptional repressor with Zn(2)-Cys(6) finger genetic 1 1 1 Synthetic Growth Defect
NBP2 YDR162C Protein involved in the HOG (high osmolarity glycerol) pathway genetic 1 1 1 Synthetic Growth Defect
UBI4 YLL039C Ubiquitin genetic 1 1 1 Synthetic Growth Defect
VAC8 YEL013W Vacuole-specific Myo2p receptor genetic 1 1 1 Synthetic Growth Defect
FDO1 YMR144W Protein involved in directionality of mating type switching genetic 1 1 1 Synthetic Growth Defect
YGL039W YGL039W Aldehyde reductase genetic 1 1 1 Synthetic Growth Defect
RIM101 YHL027W Cys2His2 zinc-finger transcriptional repressor genetic 1 1 1 Synthetic Growth Defect
OPI3 YJR073C Methylene-fatty-acyl-phospholipid synthase genetic 1 1 1 Synthetic Growth Defect
ZRC1 YMR243C Vacuolar membrane zinc transporter genetic 1 1 1 Synthetic Growth Defect
MIG1 YGL035C Transcription factor involved in glucose repression genetic 1 1 1 Synthetic Growth Defect
LAS21 YJL062W Mannose-ethanolamine phosphotransferase genetic 1 1 1 Synthetic Growth Defect
GTR2 YGR163W Subunit of a TORC1-stimulating GTPase and the EGO/GSE complex genetic 1 1 1 Synthetic Growth Defect
IES2 YNL215W Protein that associates with the INO80 chromatin remodeling complex genetic 1 1 1 Synthetic Growth Defect
MMM1 YLL006W ER integral membrane protein, ERMES complex subunit genetic 1 1 1 Synthetic Growth Defect
VID22 YLR373C G-quadruplex (G4) DNA binding protein genetic 1 1 1 Synthetic Growth Defect
SMA2 YML066C Meiosis-specific prospore membrane protein genetic 1 1 1 Synthetic Growth Defect
PKP1 YIL042C Mitochondrial protein kinase genetic 1 1 1 Synthetic Growth Defect
MSP1 YGR028W Highly-conserved N-terminally anchored AAA-ATPase genetic 1 1 1 Synthetic Growth Defect
SKY1 YMR216C SR protein kinase (SRPK) genetic 1 1 1 Synthetic Growth Defect
PRY3 YJL078C GPI-anchored cell wall protein involved in export of sterols genetic 1 1 1 Synthetic Growth Defect
RIE1 YGR250C RNA binding protein and negative regulator of START genetic 1 1 1 Synthetic Growth Defect
HKR1 YDR420W Mucin family member that functions as an osmosensor in the HOG pathway genetic 1 1 1 Synthetic Growth Defect
MDS3 YGL197W Putative component of the TOR regulatory pathway genetic 1 1 1 Synthetic Growth Defect
MTC1 YJL123C Protein of unknown function that may interact with ribosomes genetic 1 1 1 Synthetic Growth Defect
UBP8 YMR223W Ubiquitin-specific protease component of the SAGA acetylation complex genetic 1 1 1 Synthetic Growth Defect
SOP4 YJL192C ER-membrane protein genetic 1 1 1 Synthetic Growth Defect
FPS1 YLL043W Aquaglyceroporin, plasma membrane channel genetic 1 1 1 Synthetic Growth Defect
RAD6 YGL058W Ubiquitin-conjugating enzyme (E2) genetic 1 1 1 Synthetic Growth Defect
SCW4 YGR279C Cell wall protein with similarity to glucanases genetic 1 1 1 Synthetic Growth Defect
INO2 YDR123C Transcription factor genetic 1 1 1 Synthetic Growth Defect
OCA6 YDR067C Cytoplasmic protein required for replication of Brome mosaic virus genetic 1 1 1 Synthetic Growth Defect
GIM3 YNL153C Subunit of the heterohexameric cochaperone prefoldin complex genetic 1 1 1 Synthetic Growth Defect
SKI8 YGL213C Ski complex component and WD-repeat protein genetic 1 1 1 Synthetic Growth Defect
PLP1 YDR183W Protein that interacts with CCT (chaperonin containing TCP-1) complex genetic 1 1 1 Synthetic Growth Defect
HTZ1 YOL012C Histone variant H2AZ genetic 1 1 1 Synthetic Growth Defect
VAM6 YDL077C Guanine nucleotide exchange factor for the GTPase Gtr1p genetic 1 1 1 Synthetic Growth Defect
FAR7 YFR008W Protein involved in recovery from pheromone-induced cell cycle arrest genetic 1 1 1 Synthetic Growth Defect
HOM2 YDR158W Aspartic beta semi-aldehyde dehydrogenase genetic 1 1 1 Synthetic Growth Defect
RTS1 YOR014W B-type regulatory subunit of protein phosphatase 2A (PP2A) genetic 1 1 1 Synthetic Growth Defect
SWD3 YBR175W Essential subunit of the COMPASS (Set1C) complex genetic 1 1 1 Synthetic Growth Defect
RPL11B YGR085C Ribosomal 60S subunit protein L11B genetic 1 1 1 Synthetic Growth Defect
FMC1 YIL098C Mitochondrial matrix protein genetic 1 1 1 Synthetic Growth Defect
PDA1 YER178W E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex genetic 1 1 1 Synthetic Growth Defect
MSS18 YPR134W Nuclear encoded protein needed for splicing of mitochondrial intron genetic 1 1 1 Synthetic Growth Defect
SLA1 YBL007C Cytoskeletal protein binding protein genetic 1 1 1 Synthetic Growth Defect
RPS18B YML026C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Synthetic Growth Defect
PHO80 YOL001W Cyclin genetic 1 1 1 Synthetic Growth Defect
HTD2 YHR067W Mitochondrial 3-hydroxyacyl-thioester dehydratase genetic 1 1 1 Synthetic Growth Defect
RPL6B YLR448W Ribosomal 60S subunit protein L6B genetic 1 1 1 Synthetic Growth Defect
MGA2 YIR033W ER membrane protein involved in regulation of OLE1 transcription genetic 1 1 1 Synthetic Growth Defect
SSF1 YHR066W Constituent of 66S pre-ribosomal particles genetic 1 1 1 Synthetic Growth Defect
TPS1 YBR126C Synthase subunit of trehalose-6-P synthase/phosphatase complex genetic 1 1 1 Synthetic Growth Defect
MNN10 YDR245W Subunit of a Golgi mannosyltransferase complex genetic 1 1 1 Synthetic Growth Defect
IPK1 YDR315C Inositol 1,3,4,5,6-pentakisphosphate 2-kinase genetic 1 1 1 Synthetic Growth Defect
IST3 YIR005W Component of the U2 snRNP genetic 1 1 1 Synthetic Growth Defect
RPP1B YDL130W Ribosomal protein P1 beta genetic 1 1 1 Synthetic Growth Defect
RPL13A YDL082W Ribosomal 60S subunit protein L13A genetic 1 1 1 Synthetic Growth Defect
RPL40B YKR094C Ubiquitin-ribosomal 60S subunit protein L40B fusion protein genetic 1 1 1 Synthetic Growth Defect
HAP5 YOR358W Subunit of the Hap2p/3p/4p/5p CCAAT-binding complex genetic 1 1 1 Synthetic Growth Defect
SPE2 YOL052C S-adenosylmethionine decarboxylase genetic 1 1 1 Synthetic Growth Defect
RIM9 YMR063W Plasma membrane protein of unknown function genetic 1 1 1 Synthetic Growth Defect
NUM1 YDR150W Protein required for nuclear migration genetic 1 1 1 Synthetic Growth Defect
HAP2 YGL237C Subunit of the Hap2p/3p/4p/5p CCAAT-binding complex genetic 1 1 1 Synthetic Growth Defect
HFA1 YMR207C Mitochondrial acetyl-coenzyme A carboxylase genetic 1 1 1 Synthetic Growth Defect
PEX15 YOL044W Tail-anchored type II integral peroxisomal membrane protein genetic 1 1 1 Synthetic Growth Defect
RTC6 YPL183W-A Protein involved in translation genetic 1 1 1 Synthetic Growth Defect
ZRT1 YGL255W High-affinity zinc transporter of the plasma membrane genetic 1 1 1 Synthetic Growth Defect
RPS0A YGR214W Ribosomal 40S subunit protein S0A genetic 1 1 1 Synthetic Growth Defect
PEX2 YJL210W RING-finger peroxin and E3 ubiquitin ligase genetic 1 1 1 Synthetic Growth Defect
PEP8 YJL053W Vacuolar protein component of the retromer genetic 1 1 1 Synthetic Growth Defect
PTH1 YHR189W One of two mitochondrially-localized peptidyl-tRNA hydrolases genetic 1 1 1 Synthetic Growth Defect
GYP1 YOR070C Cis-golgi GTPase-activating protein (GAP) for yeast Rabs genetic 1 1 1 Synthetic Growth Defect
HAL5 YJL165C Snf1p-related nutrient-responsive protein kinase genetic 1 1 1 Synthetic Growth Defect
IDH1 YNL037C Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase genetic 1 1 1 Synthetic Growth Defect
SRO7 YPR032W Effector of Rab GTPase Sec4p genetic 1 1 1 Synthetic Growth Defect
YGR122W YGR122W Protein that may be involved in pH regulation genetic 1 1 1 Synthetic Growth Defect
MON1 YGL124C Subunit of a heterodimeric guanine nucleotide exchange factor (GEF) genetic 1 1 1 Synthetic Growth Defect
SHE4 YOR035C Protein containing a UCS (UNC-45/CRO1/SHE4) domain genetic 1 1 1 Synthetic Growth Defect
SRP40 YKR092C Nucleolar serine-rich protein genetic 1 1 1 Synthetic Growth Defect
RPL24A YGL031C Ribosomal 60S subunit protein L24A genetic 1 1 1 Synthetic Growth Defect
TLG2 YOL018C Syntaxin-like t-SNARE genetic 1 1 1 Synthetic Growth Defect
YPT7 YML001W Rab family GTPase genetic 1 1 1 Synthetic Growth Defect
MOG1 YJR074W Conserved nuclear protein that interacts with GTP-Gsp1p genetic 1 1 1 Synthetic Growth Defect
PEX10 YDR265W Peroxisomal membrane E3 ubiquitin ligase genetic 1 1 1 Synthetic Growth Defect
MDM38 YOL027C Membrane-associated mitochondrial ribosome receptor genetic 1 1 1 Synthetic Growth Defect
OLA1 YBR025C P-loop ATPase with similarity to human OLA1 and bacterial YchF genetic 1 1 1 Synthetic Growth Defect
RPL9A YGL147C Ribosomal 60S subunit protein L9A genetic 1 1 1 Synthetic Growth Defect
TPM1 YNL079C Major isoform of tropomyosin genetic 1 1 1 Synthetic Growth Defect
PMP3 YDR276C Small plasma membrane protein genetic 1 1 1 Synthetic Growth Defect
RAD27 YKL113C 5' to 3' exonuclease, 5' flap endonuclease genetic 1 1 1 Synthetic Growth Defect
MET22 YOL064C Bisphosphate-3'-nucleotidase genetic 1 1 1 Synthetic Growth Defect
TRP4 YDR354W Anthranilate phosphoribosyl transferase genetic 1 1 1 Synthetic Growth Defect
SGF29 YCL010C Component of the HAT/Core module of the SAGA, SLIK, and ADA complexes genetic 1 1 1 Synthetic Growth Defect
PEX8 YGR077C Intraperoxisomal organizer of the peroxisomal import machinery genetic 1 1 1 Synthetic Growth Defect
QCR9 YGR183C Subunit 9 of ubiquinol cytochrome-c reductase (Complex III) genetic 1 1 1 Synthetic Growth Defect
SLX9 YGR081C Protein required for pre-rRNA processing genetic 1 1 1 Synthetic Growth Defect
SSO2 YMR183C Plasma membrane t-SNARE genetic 1 1 1 Synthetic Growth Defect
RPS10B YMR230W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Synthetic Growth Defect
SWD1 YAR003W Subunit of the COMPASS (Set1C) complex genetic 1 1 1 Synthetic Growth Defect
STE50 YCL032W Adaptor protein for various signaling pathways genetic 1 1 1 Synthetic Growth Defect
RPS7B YNL096C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Synthetic Growth Defect
RPE1 YJL121C D-ribulose-5-phosphate 3-epimerase genetic 1 1 1 Synthetic Growth Defect
URM1 YIL008W Ubiquitin-like protein involved in thiolation of cytoplasmic tRNAs genetic 1 1 1 Synthetic Growth Defect
PEX19 YDL065C Chaperone and import receptor for newly-synthesized class I PMPs genetic 1 1 1 Synthetic Growth Defect
MDL2 YPL270W Mitochondrial inner membrane half-type ABC transporter genetic 1 1 1 Synthetic Growth Defect
SUR1 YPL057C Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit genetic 1 1 1 Synthetic Growth Defect
VSB1 YGR125W Vacuolar membrane protein required for uptake and storage of arginine genetic 1 1 1 Synthetic Growth Defect
RPL8A YHL033C Ribosomal 60S subunit protein L8A genetic 1 1 1 Synthetic Growth Defect
SWI5 YDR146C Transcription factor that recruits Mediator and Swi/Snf complexes genetic 1 1 1 Synthetic Growth Defect
YKL069W YKL069W Methionine-R-sulfoxide reductase genetic 1 1 1 Synthetic Growth Defect
NOT3 YIL038C Component of the CCR4-NOT core complex, involved in mRNA decapping genetic 1 1 1 Synthetic Growth Defect
GIS4 YML006C CAAX box containing protein of unknown function genetic 1 1 1 Synthetic Growth Defect
PEX1 YKL197C AAA-peroxin genetic 1 1 1 Synthetic Growth Defect
GDS1 YOR355W Protein involved in histone H4 acetylation at ribosomal protein genes genetic 1 1 1 Synthetic Growth Defect
TRS85 YDR108W Component of transport protein particle (TRAPP) complex III genetic 1 1 1 Synthetic Growth Defect
UBC4 YBR082C Ubiquitin-conjugating enzyme (E2) genetic 1 1 1 Synthetic Growth Defect
PEX12 YMR026C C3HC4-type RING-finger peroxin and E3 ubiquitin ligase genetic 1 1 1 Synthetic Growth Defect
HAP4 YKL109W Transcription factor genetic 1 1 1 Synthetic Growth Defect
UBA3 YPR066W Protein that activates Rub1p (NEDD8) before neddylation genetic 1 1 1 Synthetic Growth Defect
RAD4 YER162C Damaged-DNA binding subunit of Nuclear Excision Repair Factor 2 genetic 1 1 1 Synthetic Growth Defect
PIH1 YHR034C Component of the conserved R2TP complex (Rvb1-Rvb2-Tah1-Pih1) genetic 1 1 1 Synthetic Growth Defect
UBA4 YHR111W E1-like protein that activates Urm1p before urmylation genetic 1 1 1 Synthetic Growth Defect
HDA3 YPR179C Subunit of HDA1 histone deacetylase complex genetic 1 1 1 Synthetic Growth Defect
WHI5 YOR083W Repressor of G1 transcription genetic 1 1 1 Synthetic Growth Defect
INP1 YMR204C Peripheral membrane protein of peroxisomes genetic 1 1 1 Synthetic Growth Defect
RPA14 YDR156W RNA polymerase I subunit A14 genetic 1 1 1 Synthetic Growth Defect
VMS1 YDR049W Peptidyl-tRNA hydrolase that releases stalled peptides from ribosomes, genetic 1 1 1 Synthetic Growth Defect
GUP1 YGL084C Plasma membrane protein involved in remodeling GPI anchors genetic 1 1 1 Synthetic Growth Defect
MRC1 YCL061C S-phase checkpoint protein required for DNA replication genetic 1 1 1 Synthetic Growth Defect
TOP1 YOL006C Topoisomerase I genetic 1 1 1 Synthetic Growth Defect
RPS25A YGR027C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Synthetic Growth Defect
MAK3 YPR051W Catalytic subunit of the NatC type N-terminal acetyltransferase (NAT) genetic 1 1 1 Synthetic Growth Defect
FUM1 YPL262W Fumarase genetic 1 1 1 Synthetic Growth Defect
RPL9B YNL067W Ribosomal 60S subunit protein L9B genetic 1 1 1 Synthetic Growth Defect
OMS1 YDR316W Protein integral to the mitochondrial membrane genetic 1 1 1 Synthetic Growth Defect
MGR3 YMR115W Subunit of the mitochondrial (mt) i-AAA protease supercomplex genetic 1 1 1 Synthetic Growth Defect
PEX3 YDR329C Peroxisomal membrane protein (PMP) genetic 1 1 1 Synthetic Growth Defect
PMA2 YPL036W Plasma membrane H+-ATPase genetic 1 1 1 Synthetic Growth Defect
PEX22 YAL055W Putative peroxisomal membrane protein genetic 1 1 1 Synthetic Growth Defect
RPL17B YJL177W Ribosomal 60S subunit protein L17B genetic 1 1 1 Synthetic Growth Defect
SWC5 YBR231C Component of the SWR1 complex genetic 1 1 1 Synthetic Growth Defect
RPS21A YKR057W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Synthetic Growth Defect
SWF1 YDR126W Palmitoyltransferase that acts on transmembrane proteins genetic 1 1 1 Synthetic Growth Defect
KAP122 YGL016W Karyopherin beta genetic 1 1 1 Synthetic Growth Defect
MRN1 YPL184C RNA-binding protein that may be involved in translational regulation genetic 1 1 1 Synthetic Growth Defect
LSM1 YJL124C Lsm (Like Sm) protein genetic 1 1 1 Synthetic Growth Defect
YAR029W YAR029W Member of DUP240 gene family but contains no transmembrane domains genetic 1 1 1 Synthetic Growth Defect
SGF11 YPL047W Integral subunit of SAGA histone acetyltransferase complex genetic 1 1 1 Synthetic Growth Defect
THR4 YCR053W Threonine synthase genetic 1 1 1 Synthetic Growth Defect
SPE3 YPR069C Spermidine synthase genetic 1 1 1 Synthetic Growth Defect
KAR3 YPR141C Minus-end-directed microtubule motor genetic 1 1 1 Synthetic Growth Defect
SNF6 YHL025W Subunit of the SWI/SNF chromatin remodeling complex genetic 1 1 1 Synthetic Growth Defect
PAR32 YDL173W Low complexity protein genetic 1 1 1 Synthetic Growth Defect
MRX19 YDL183C Protein that may form an active mitochondrial KHE system genetic 1 1 1 Synthetic Growth Defect
SCT1 YBL011W Glycerol 3-phosphate/dihydroxyacetone phosphate sn-1 acyltransferase genetic 1 1 1 Synthetic Growth Defect
VPS4 YPR173C AAA-ATPase involved in multivesicular body (MVB) protein sorting genetic 1 1 1 Synthetic Growth Defect
RPN4 YDL020C Transcription factor that stimulates expression of proteasome genes genetic 1 1 1 Synthetic Growth Defect
MAL12 YGR292W Maltase (alpha-D-glucosidase) genetic 1 1 1 Synthetic Growth Defect
SHE1 YBL031W Mitotic spindle protein genetic 1 1 1 Synthetic Growth Defect
TAX4 YJL083W EH domain-containing protein genetic 1 1 1 Synthetic Growth Defect
SEC66 YBR171W Non-essential subunit of Sec63 complex genetic 1 1 1 Synthetic Growth Defect
SPF1 YEL031W P-type ATPase, ion transporter of the ER membrane genetic 1 1 1 Synthetic Growth Defect
MET10 YFR030W Subunit alpha of assimilatory sulfite reductase genetic 1 1 1 Synthetic Growth Defect
GRS1 YBR121C Cytoplasmic and mitochondrial glycyl-tRNA synthase genetic 1 1 1 Synthetic Growth Defect
PDC5 YLR134W Minor isoform of pyruvate decarboxylase genetic 1 1 1 Synthetic Growth Defect
RTC2 YBR147W Putative vacuolar membrane transporter for cationic amino acids genetic 1 1 1 Synthetic Growth Defect
SOL4 YGR248W 6-phosphogluconolactonase genetic 1 1 1 Synthetic Growth Defect
MMS1 YPR164W Subunit of E3 ubiquitin ligase complex involved in replication repair genetic 1 1 1 Synthetic Growth Defect
RMI1 YPL024W Subunit of the RecQ (Sgs1p) - Topo III (Top3p) complex genetic 1 1 1 Synthetic Growth Defect
YLR108C YLR108C Protein of unknown function genetic 1 1 1 Synthetic Growth Defect
RIF2 YLR453C Protein that binds to the Rap1p C-terminus genetic 1 1 1 Phenotypic Enhancement
MED1 YPR070W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Synthetic Growth Defect
TEF4 YKL081W Gamma subunit of translational elongation factor eEF1B genetic 1 1 1 Synthetic Growth Defect
OPI1 YHL020C Transcriptional regulator of a variety of genes genetic 1 1 1 Synthetic Growth Defect
RTF1 YGL244W Subunit of RNAPII-associated chromatin remodeling Paf1 complex genetic 1 1 1 Synthetic Growth Defect
SAP155 YFR040W Protein required for function of the Sit4p protein phosphatase genetic 1 1 1 Synthetic Growth Defect
MTC5 YDR128W Subunit of SEACAT, a subcomplex of the SEA complex genetic 1 1 1 Synthetic Growth Defect
VAM10 YOR068C Protein involved in vacuole morphogenesis genetic 1 1 1 Synthetic Growth Defect
GEM1 YAL048C Outer mitochondrial membrane GTPase, subunit of the ERMES complex genetic 1 1 1 Synthetic Growth Defect
NHP10 YDL002C Non-essential INO80 chromatin remodeling complex subunit genetic 1 1 1 Synthetic Growth Defect
VPS5 YOR069W Nexin-1 homolog genetic 1 1 1 Synthetic Growth Defect
SLX5 YDL013W Subunit of the Slx5-Slx8 SUMO-targeted Ub ligase (STUbL) complex genetic 1 1 1 Synthetic Growth Defect
SLG1 YOR008C Sensor-transducer of the stress-activated PKC1-MPK1 kinase pathway genetic 1 1 1 Synthetic Growth Defect
RPS4A YJR145C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Synthetic Growth Defect
FAR1 YJL157C CDK inhibitor and nuclear anchor genetic 1 1 1 Synthetic Growth Defect
YGL081W YGL081W Putative protein of unknown function genetic 1 1 1 Synthetic Growth Defect
PSD1 YNL169C Phosphatidylserine decarboxylase of the mitochondrial inner membrane genetic 1 1 1 Synthetic Growth Defect
MMS22 YLR320W Subunit of E3 ubiquitin ligase complex involved in replication repair genetic 1 1 1 Synthetic Growth Defect
RPL21B YPL079W Ribosomal 60S subunit protein L21B genetic 1 1 1 Synthetic Growth Defect
ZDS2 YML109W Protein with a role in regulating Swe1p-dependent polarized growth genetic 1 1 1 Synthetic Growth Defect
PFK2 YMR205C Beta subunit of heterooctameric phosphofructokinase genetic 1 1 1 Synthetic Growth Defect
YLR287C YLR287C Putative protein of unknown function genetic 1 1 1 Synthetic Growth Defect
ICE2 YIL090W Integral ER membrane protein with type-III transmembrane domains genetic 1 1 1 Synthetic Growth Defect
SPC2 YML055W Subunit of signal peptidase complex genetic 1 1 1 Synthetic Growth Defect
GCS1 YDL226C ADP-ribosylation factor GTPase activating protein (ARF GAP) genetic 1 1 1 Synthetic Growth Defect
SIN3 YOL004W Component of both the Rpd3S and Rpd3L histone deacetylase complexes genetic 1 1 1 Synthetic Growth Defect
ETR1 YBR026C 2-enoyl thioester reductase genetic 1 1 1 Synthetic Growth Defect
VPS51 YKR020W Component of the GARP (Golgi-associated retrograde protein) complex genetic 1 1 1 Synthetic Growth Defect
SLX8 YER116C Subunit of Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex genetic 1 1 1 Synthetic Growth Defect
SGF73 YGL066W Subunit of DUBm module of SAGA and SLIK genetic 1 1 1 Synthetic Growth Defect
PHO5 YBR093C Repressible acid phosphatase genetic 1 1 1 Synthetic Growth Defect
FKS1 YLR342W Catalytic subunit of 1,3-beta-D-glucan synthase genetic 1 1 1 Synthetic Growth Defect
SOH1 YGL127C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Synthetic Growth Defect
GSH2 YOL049W Glutathione synthetase genetic 1 1 1 Synthetic Growth Defect
RPS11B YBR048W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Synthetic Growth Defect
MUB1 YMR100W MYND domain-containing protein genetic 1 1 1 Synthetic Growth Defect
NOP12 YOL041C Nucleolar protein involved in pre-25S rRNA processing genetic 1 1 1 Synthetic Growth Defect
KRE1 YNL322C Cell wall glycoprotein involved in beta-glucan assembly genetic 1 1 1 Synthetic Growth Defect
VAM3 YOR106W Syntaxin-like vacuolar t-SNARE genetic 1 1 1 Synthetic Growth Defect
SOK2 YMR016C Nuclear protein that negatively regulates pseudohyphal differentiation genetic 1 1 1 Synthetic Growth Defect
SEC28 YIL076W Epsilon-COP subunit of the coatomer genetic 1 1 1 Synthetic Growth Defect
PKR1 YMR123W V-ATPase assembly factor genetic 1 1 1 Synthetic Growth Defect
RIF1 YBR275C Protein involved in control of DNA replication genetic 1 1 1 Phenotypic Enhancement
SRP1 YNL189W Karyopherin alpha homolog genetic 1 1 1 Phenotypic Suppression
POL31 YJR006W Subunit of DNA polymerase delta (polymerase III) genetic 1 1 1 Positive Genetic
PAC11 YDR488C Dynein intermediate chain, microtubule motor protein genetic 1 1 1 Positive Genetic
TIM22 YDL217C Essential core component of mitochondrial TIM22 complex genetic 1 1 1 Negative Genetic
VRG4 YGL225W Golgi GDP-mannose transporter genetic 1 1 1 Negative Genetic
PRP24 YMR268C Splicing factor that reanneals snRNPs during spliceosome recycling genetic 1 1 1 Negative Genetic
RFC1 YOR217W Subunit of heteropentameric Replication factor C (RF-C) genetic 1 1 1 Negative Genetic
PKC1 YBL105C Protein serine/threonine kinase genetic 1 1 1 Negative Genetic
SNU23 YDL098C Component of the U4/U6.U5 snRNP complex genetic 1 1 1 Negative Genetic
SEC7 YDR170C Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors genetic 1 1 1 Negative Genetic
RPB7 YDR404C RNA polymerase II subunit B16 genetic 1 1 1 Negative Genetic
SPC105 YGL093W Subunit of a kinetochore-microtubule binding complex genetic 1 1 1 Negative Genetic
SRM1 YGL097W Nucleotide exchange factor for Gsp1p genetic 1 1 1 Negative Genetic
MAS2 YHR024C Alpha subunit of the mitochondrial processing protease (MPP) genetic 1 1 1 Negative Genetic
ORC6 YHR118C Subunit of the origin recognition complex (ORC) genetic 1 1 1 Negative Genetic
KAR2 YJL034W ATPase involved in protein import into the ER genetic 1 1 1 Negative Genetic
SEC61 YLR378C Conserved ER protein translocation channel genetic 1 1 1 Negative Genetic
LCB1 YMR296C Component of serine palmitoyltransferase genetic 1 1 1 Negative Genetic
NUF2 YOL069W Component of the kinetochore-associated Ndc80 complex genetic 1 1 1 Negative Genetic
RPB2 YOR151C RNA polymerase II second largest subunit B150 genetic 1 1 1 Negative Genetic
KAP104 YBR017C Transportin or cytosolic karyopherin beta 2 genetic 1 1 1 Negative Genetic
STP1 YDR463W Transcription factor genetic 1 1 1 Negative Genetic
HSP31 YDR533C Methylglyoxalase that converts methylglyoxal to D-lactate genetic 1 1 1 Negative Genetic
STL1 YDR536W Glycerol proton symporter of the plasma membrane genetic 1 1 1 Negative Genetic
HPA3 YEL066W D-Amino acid N-acetyltransferase that detoxifies D-amino acids genetic 1 1 1 Negative Genetic
ZRG8 YER033C Protein of unknown function genetic 1 1 1 Negative Genetic
RPS24A YER074W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
VFA1 YER128W Protein that interacts with Vps4p and has a role in vacuolar sorting genetic 1 1 1 Negative Genetic
RPS26B YER131W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
ZNF1 YFL052W Zinc cluster transcription factor that regulates respiratory growth genetic 1 1 1 Negative Genetic
RPS23A YGR118W Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
YMR244W YMR244W Putative protein of unknown function genetic 1 1 1 Negative Genetic
YNL165W YNL165W Putative protein of unknown function genetic 1 1 1 Negative Genetic
SSH1 YBR283C Subunit of the Ssh1 translocon complex genetic 1 1 1 Positive Genetic
RXT3 YDL076C Component of the Rpd3L histone deacetylase complex genetic 1 1 1 Positive Genetic
LYS20 YDL182W Homocitrate synthase isozyme and functions in DNA repair genetic 1 1 1 Positive Genetic
MNN1 YER001W Alpha-1,3-mannosyltransferase genetic 1 1 1 Positive Genetic
NOP16 YER002W Constituent of 66S pre-ribosomal particles genetic 1 1 1 Positive Genetic
FMP52 YER004W Protein of unknown function genetic 1 1 1 Positive Genetic
YND1 YER005W Apyrase with wide substrate specificity genetic 1 1 1 Positive Genetic
TMA20 YER007C-A Protein of unknown function that associates with ribosomes genetic 1 1 1 Positive Genetic
PAC2 YER007W Microtubule effector required for tubulin heterodimer formation genetic 1 1 1 Positive Genetic
YER010C YER010C Bifunctional HMG aldolase/oxaloacetate decarboxylase genetic 1 1 1 Positive Genetic
YPT31 YER031C Rab family GTPase genetic 1 1 1 Positive Genetic
FIR1 YER032W Protein involved in 3' mRNA processing genetic 1 1 1 Positive Genetic
MDM34 YGL219C Mitochondrial component of the ERMES complex genetic 1 1 1 Positive Genetic
YJL070C YJL070C Putative metallo-dependent hydrolase superfamily protein genetic 1 1 1 Positive Genetic
SPT8 YLR055C Subunit of the SAGA transcriptional regulatory complex genetic 1 1 1 Positive Genetic
RFU1 YLR073C Protein that inhibits Doa4p deubiquitinating activity genetic 1 1 1 Positive Genetic
FMP25 YLR077W Protein required for assembly of respiratory complex III genetic 1 1 1 Positive Genetic
SRN2 YLR119W Component of the ESCRT-I complex genetic 1 1 1 Positive Genetic
MDL1 YLR188W Mitochondrial inner membrane half-type ABC transporter genetic 1 1 1 Positive Genetic
PEX13 YLR191W Peroxisomal importomer complex component genetic 1 1 1 Positive Genetic
RPS30A YLR287C-A Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Positive Genetic
IKI3 YLR384C Subunit of Elongator complex genetic 1 1 1 Positive Genetic
PAH1 YMR165C Mg2+-dependent phosphatidate (PA) phosphatase genetic 1 1 1 Positive Genetic
RPL16B YNL069C Ribosomal 60S subunit protein L16B genetic 1 1 1 Positive Genetic
RAS2 YNL098C GTP-binding protein genetic 1 1 1 Positive Genetic
GCR2 YNL199C Transcriptional activator of genes involved in glycolysis genetic 1 1 1 Positive Genetic
SQS1 YNL224C Protein that stimulates the ATPase and helicase activities of Prp43p genetic 1 1 1 Positive Genetic
YNL234W YNL234W Protein of unknown function with similarity to globins genetic 1 1 1 Positive Genetic
YTP1 YNL237W Probable type-III integral membrane protein of unknown function genetic 1 1 1 Positive Genetic
RTC4 YNL254C Protein of unknown function genetic 1 1 1 Positive Genetic
GOR1 YNL274C Glyoxylate reductase genetic 1 1 1 Positive Genetic
SIL1 YOL031C Nucleotide exchange factor for the ER lumenal Hsp70 chaperone Kar2p genetic 1 1 1 Positive Genetic
IRA2 YOL081W GTPase-activating protein genetic 1 1 1 Positive Genetic
VPS68 YOL129W Vacuolar membrane protein of unknown function genetic 1 1 1 Positive Genetic
GAS4 YOL132W 1,3-beta-glucanosyltransferase genetic 1 1 1 Positive Genetic
RTC1 YOL138C Subunit of SEACAT, a subcomplex of the SEA complex genetic 1 1 1 Positive Genetic
FYV12 YOR183W Protein of unknown function genetic 1 1 1 Positive Genetic
MET12 YPL023C Protein with MTHFR activity in vitro genetic 1 1 1 Positive Genetic
TSA1 YML028W Thioredoxin peroxidase genetic 1 1 1 Synthetic Growth Defect
RGT2 YDL138W Plasma membrane high glucose sensor that regulates glucose transport genetic 1 1 1 Negative Genetic
MAF1 YDR005C Highly conserved negative regulator of RNA polymerase III genetic 1 1 1 Negative Genetic
POT1 YIL160C 3-ketoacyl-CoA thiolase with broad chain length specificity genetic 1 1 1 Negative Genetic
WHI2 YOR043W Negative regulator of TORC1 in response to limiting leucine genetic 1 1 1 Negative Genetic
RIM20 YOR275C Protein involved in proteolytic activation of Rim101p genetic 1 1 1 Negative Genetic
TUB4 YLR212C Gamma-tubulin genetic 1 1 1 Synthetic Growth Defect
DOG1 YHR044C 2-deoxyglucose-6-phosphate phosphatase genetic 1 1 1 Synthetic Growth Defect
CAC2 YML102W Subunit of chromatin assembly factor I (CAF-1), with Rlf2p and Msi1p genetic 1 1 1 Synthetic Growth Defect
DIA2 YOR080W Origin-binding F-box protein genetic 1 1 1 Synthetic Growth Defect
CTF4 YPR135W Chromatin-associated protein genetic 1 1 1 Synthetic Growth Defect
ATG4 YNL223W Conserved cysteine protease required for autophagy genetic 1 1 1 Positive Genetic
CIK1 YMR198W Kinesin-associated protein genetic 1 1 1 Synthetic Growth Defect
EAP1 YKL204W eIF4E-associated protein, competes with eIF4G for binding to eIF4E genetic 1 1 1 Synthetic Growth Defect
BUB3 YOR026W Kinetochore checkpoint WD40 repeat protein genetic 1 1 1 Phenotypic Suppression
APE2 YKL157W Aminopeptidase yscII genetic 1 1 1 Positive Genetic
CDH1 YGL003C Activator of anaphase-promoting complex/cyclosome (APC/C) genetic 1 1 1 Negative Genetic
BIR1 YJR089W Subunit of chromosomal passenger complex (CPC) genetic 1 1 1 Negative Genetic
CIN4 YMR138W GTP-binding protein involved in beta-tubulin (Tub2p) folding genetic 1 1 1 Synthetic Growth Defect
AFT1 YGL071W Transcription factor involved in iron utilization and homeostasis genetic 1 1 1 Synthetic Growth Defect
CDC34 YDR054C Ubiquitin-conjugating enzyme (E2) genetic 1 1 1 Positive Genetic
BAS1 YKR099W Myb-related transcription factor genetic 1 1 1 Synthetic Growth Defect
ACF4 YJR083C Protein of unknown function genetic 1 1 1 Synthetic Growth Defect
ASK10 YGR097W Regulator of the Fps1p glycerol channel genetic 1 1 1 Synthetic Growth Defect
ELP6 YMR312W Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex genetic 1 1 1 Synthetic Growth Defect
COG4 YPR105C Essential component of the conserved oligomeric Golgi complex genetic 1 1 1 Negative Genetic
AIM4 YBR194W Protein proposed to be associated with the nuclear pore complex genetic 1 1 1 Synthetic Growth Defect
APC5 YOR249C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 1 1 1 Positive Genetic
CEP3 YMR168C Essential kinetochore protein genetic 1 1 1 Negative Genetic
ELP3 YPL086C Subunit of Elongator complex genetic 1 1 1 Synthetic Growth Defect
ELP4 YPL101W Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex genetic 1 1 1 Synthetic Growth Defect
CDC21 YOR074C Thymidylate synthase genetic 1 1 1 Negative Genetic
ARP6 YLR085C Actin-related protein that binds nucleosomes genetic 1 1 1 Synthetic Growth Defect
DAL81 YIR023W Positive regulator of genes in multiple nitrogen degradation pathways genetic 1 1 1 Synthetic Growth Defect
ATG8 YBL078C Ub-like protein genetic 1 1 1 Synthetic Growth Defect
BRN1 YBL097W Subunit of the condensin complex genetic 1 1 1 Positive Genetic
CLC1 YGR167W Clathrin light chain genetic 1 1 1 Positive Genetic
CTF8 YHR191C Subunit of a complex with Ctf18p genetic 1 1 1 Synthetic Growth Defect
DBF4 YDR052C Regulatory subunit of Cdc7p-Dbf4p kinase complex genetic 1 1 1 Negative Genetic
ELO3 YLR372W Elongase genetic 1 1 1 Phenotypic Enhancement
EPS1 YIL005W ER protein with chaperone and co-chaperone activity physical 1 1 1 Affinity Capture-MS
ECO1 YFR027W Acetyltransferase required for sister chromatid cohesion physical 1 1 1 Reconstituted Complex
ECO1 YFR027W Acetyltransferase required for sister chromatid cohesion genetic 1 1 1 Synthetic Growth Defect
CCZ1 YBR131W Subunit of a heterodimeric guanine nucleotide exchange factor (GEF) genetic 1 1 1 Synthetic Growth Defect
ATG2 YNL242W Peripheral membrane protein required for autophagic vesicle formation genetic 1 1 1 Positive Genetic
CSG2 YBR036C Endoplasmic reticulum membrane protein genetic 1 1 1 Synthetic Growth Defect
ESC1 YMR219W Protein involved in telomeric silencing physical 1 1 1 Affinity Capture-MS
CLA4 YNL298W Cdc42p-activated signal transducing kinase genetic 1 1 1 Synthetic Growth Defect
COX17 YLL009C Copper metallochaperone that transfers copper to Sco1p and Cox11p genetic 1 1 1 Synthetic Growth Defect
BCS1 YDR375C Protein translocase and chaperone required for Complex III assembly genetic 1 1 1 Synthetic Growth Defect
DID2 YKR035W-A Class E protein of the vacuolar protein-sorting (Vps) pathway genetic 1 1 1 Synthetic Growth Defect
COX14 YML129C Mitochondrial cytochrome c oxidase (complex IV) assembly factor genetic 1 1 1 Synthetic Growth Defect
EAF7 YNL136W Subunit of the NuA4 histone acetyltransferase complex genetic 1 1 1 Synthetic Growth Defect
AIM44 YPL158C Regulator of Cdc42p and Rho1p genetic 1 1 1 Synthetic Growth Defect
COY1 YKL179C Golgi membrane protein with similarity to mammalian CASP genetic 1 1 1 Synthetic Growth Defect
CPS1 YJL172W Vacuolar carboxypeptidase S genetic 1 1 1 Synthetic Growth Defect
CAT2 YML042W Carnitine acetyl-CoA transferase genetic 1 1 1 Synthetic Growth Defect
ERG2 YMR202W C-8 sterol isomerase genetic 1 1 1 Synthetic Growth Defect
DCC1 YCL016C Subunit of a complex with Ctf8p and Ctf18p genetic 1 1 1 Synthetic Growth Defect
COQ10 YOL008W Coenzyme Q (ubiquinone) binding protein genetic 1 1 1 Synthetic Growth Defect
BUL2 YML111W Alpha-arrestin, component of the Rsp5p E3-ubiquitin ligase complex genetic 1 1 1 Synthetic Growth Defect
ATG32 YIL146C Mitochondrial outer membrane protein required to initiate mitophagy genetic 1 1 1 Synthetic Growth Defect
ACB1 YGR037C Acyl-CoA-binding protein genetic 1 1 1 Synthetic Growth Defect
CYK3 YDL117W SH3-domain protein located in the bud neck and cytokinetic actin ring genetic 1 1 1 Synthetic Growth Defect
ALT1 YLR089C Alanine transaminase (glutamic pyruvic transaminase) genetic 1 1 1 Positive Genetic
ARO2 YGL148W Bifunctional chorismate synthase and flavin reductase genetic 1 1 1 Synthetic Growth Defect
DEG1 YFL001W tRNA:pseudouridine synthase genetic 1 1 1 Synthetic Growth Defect
APS2 YJR058C Small subunit of the clathrin-associated adaptor complex AP-2 genetic 1 1 1 Synthetic Growth Defect
CYT1 YOR065W Cytochrome c1 genetic 1 1 1 Synthetic Growth Defect
DCR2 YLR361C Protein phosphatase genetic 1 1 1 Synthetic Growth Defect
COQ2 YNR041C Para hydroxybenzoate polyprenyl transferase genetic 1 1 1 Synthetic Growth Defect
DFG16 YOR030W Probable multiple transmembrane protein genetic 1 1 1 Synthetic Growth Defect
AIM34 YMR003W Protein of unknown function genetic 1 1 1 Synthetic Growth Defect
CEM1 YER061C Mitochondrial beta-keto-acyl synthase genetic 1 1 1 Negative Genetic
CGR1 YGL029W Protein involved in nucleolar integrity and processing of pre-rRNA genetic 1 1 1 Synthetic Growth Defect
CHO2 YGR157W Phosphatidylethanolamine methyltransferase (PEMT) genetic 1 1 1 Synthetic Growth Defect
COX23 YHR116W Protein that functions in mitochondrial copper homeostasis genetic 1 1 1 Synthetic Growth Defect
ERG3 YLR056W C-5 sterol desaturase genetic 1 1 1 Positive Genetic
CDC8 YJR057W Nucleoside monophosphate and nucleoside diphosphate kinase genetic 1 1 1 Negative Genetic
AVL9 YLR114C Conserved protein involved in exocytic transport from the Golgi genetic 1 1 1 Synthetic Growth Defect
ALG9 YNL219C Mannosyltransferase, involved in N-linked glycosylation genetic 1 1 1 Positive Genetic
CTS1 YLR286C Endochitinase genetic 1 1 1 Synthetic Growth Defect
ATG41 YPL250C Protein of unknown function genetic 1 1 1 Negative Genetic
EMI1 YDR512C Non-essential protein of unknown function genetic 1 1 1 Synthetic Growth Defect
COX12 YLR038C Subunit VIb of cytochrome c oxidase genetic 1 1 1 Synthetic Growth Defect
AVT5 YBL089W Putative transporter genetic 1 1 1 Synthetic Growth Defect
APA2 YDR530C Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase II genetic 1 1 1 Negative Genetic
DOG2 YHR043C 2-deoxyglucose-6-phosphate phosphatase genetic 1 1 1 Synthetic Growth Defect
ATG40 YOR152C Autophagy receptor with a role in endoplasmic reticulum degradation genetic 1 1 1 Negative Genetic
DCV1 YFR012W Protein of unknown function genetic 1 1 1 Synthetic Growth Defect
ALD3 YMR169C Cytoplasmic aldehyde dehydrogenase genetic 1 1 1 Synthetic Growth Defect
DFR1 YOR236W Dihydrofolate reductase involved in tetrahydrofolate biosynthesis genetic 1 1 1 Negative Genetic
ATR2 YMR279C Putative boron transporter involved in boron efflux and resistance genetic 1 1 1 Negative Genetic
CIS1 YLR346C Protein of unknown function found in mitochondria genetic 1 1 1 Positive Genetic
APQ12 YIL040W Nuclear envelope/ER integral membrane protein genetic 1 1 1 Synthetic Growth Defect
ECM8 YBR076W Non-essential protein of unknown function genetic 1 1 1 Synthetic Growth Defect