Standard name Systematic name Name description Description
FPK1 YNR047W Ser/Thr protein kinase Ser/Thr protein kinase; phosphorylates several aminophospholipid translocase family members, regulating phospholipid translocation and membrane asymmetry; phosphorylates and inhibits the protein kinase Akl1p, stimulating endocytosis; phosphorylates and inhibits upstream inhibitory kinase Ypk1p; localizes to the cytoplasm, early endosome/TGN, the plasma membrane and the shmoo tip; redundant role with KIN82 in the mating pheromone response; activity stimulated by Gin4p kinase and sphingolipid MIPC
Visualize the interactome of FPK1
Links to external databases:
SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Cell Periphery 0.190 0.207 0.175
Cytoplasm 0.921 0.909 0.964

GFP localization & abundance

GFP localization GFP abundance
no data no data

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
FPK1 1 0 0 0 0

Enzyme information

Catalyzed reactions in Yeast8

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
YPK1 YKL126W S/T protein kinase genetic 5 3 4 Synthetic Rescue, Synthetic Rescue, Phenotypic Suppression, Dosage Growth Defect, Phenotypic Suppression
YPK1 YKL126W S/T protein kinase physical 5 1 4 Biochemical Activity, Biochemical Activity, Biochemical Activity, Biochemical Activity, Biochemical Activity
KIN82 YCR091W Putative serine/threonine protein kinase genetic 3 2 3 Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Enhancement
FUS3 YBL016W Mitogen-activated serine/threonine protein kinase involved in mating genetic 3 1 3 Positive Genetic, Positive Genetic, Positive Genetic
DNF3 YMR162C Trans-golgi network aminophospholipid translocase (flippase) regulation 2 2 2 protein kinase assay evidence, qualitative western immunoblotting evidence
GIN4 YDR507C Protein kinase involved in bud growth and assembly of the septin ring genetic 2 2 2 Dosage Growth Defect, Phenotypic Suppression
BEM1 YBR200W Protein containing SH3-domains genetic 2 1 2 Negative Genetic, Negative Genetic
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit physical 2 1 2 Biochemical Activity, Biochemical Activity
ELP2 YGR200C Subunit of Elongator complex genetic 2 1 2 Negative Genetic, Negative Genetic
AKL1 YBR059C Ser/Thr protein kinase physical 2 1 2 Biochemical Activity, Biochemical Activity
UBP15 YMR304W Ubiquitin-specific protease involved in protein deubiquitination physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
RIC1 YLR039C Protein involved in retrograde transport to the cis-Golgi network genetic 2 1 2 Positive Genetic, Positive Genetic
VMA1 YDL185W Subunit A of the V1 peripheral membrane domain of V-ATPase genetic 2 1 2 Negative Genetic, Negative Genetic
GET1 YGL020C Subunit of the GET complex genetic 2 1 2 Positive Genetic, Positive Genetic
RSM7 YJR113C Mitochondrial ribosomal protein of the small subunit genetic 2 1 2 Negative Genetic, Negative Genetic
SCS7 YMR272C Sphingolipid alpha-hydroxylase genetic 2 1 2 Positive Genetic, Positive Genetic
DBF2 YGR092W Ser/Thr kinase involved in transcription and stress response physical 2 1 2 Biochemical Activity, Biochemical Activity
MYO1 YHR023W Type II myosin heavy chain genetic 2 2 1 Synthetic Rescue, Synthetic Growth Defect
FKH1 YIL131C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MED2 YDL005C Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
XBP1 YIL101C Transcriptional repressor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit regulation 1 1 1 quantitative mass spectrometry evidence
SUA7 YPR086W Transcription factor TFIIB regulation 1 1 1 chromatin immunoprecipitation-chip evidence
DNF1 YER166W Aminophospholipid translocase (flippase) regulation 1 1 1 protein kinase assay evidence
DNF2 YDR093W Aminophospholipid translocase (flippase) regulation 1 1 1 protein kinase assay evidence
FPK1 YNR047W Ser/Thr protein kinase regulation 1 1 1 protein kinase assay evidence
DRS2 YAL026C Trans-golgi network aminophospholipid translocase (flippase) regulation 1 1 1 protein kinase assay evidence
EAF1 YDR359C Component of the NuA4 histone acetyltransferase complex genetic 1 1 1 Positive Genetic
CDC42 YLR229C Small rho-like GTPase genetic 1 1 1 Synthetic Rescue
BMH1 YER177W 14-3-3 protein, major isoform physical 1 1 1 Affinity Capture-MS
ACT1 YFL039C Actin, structural protein in cytoskeleton genetic 1 1 1 Phenotypic Suppression
AAH1 YNL141W Adenine deaminase (adenine aminohydrolase) genetic 1 1 1 Negative Genetic
BEM1 YBR200W Protein containing SH3-domains physical 1 1 1 Two-hybrid
BMH2 YDR099W 14-3-3 protein, minor isoform physical 1 1 1 Affinity Capture-MS
CDC24 YAL041W Guanine nucleotide exchange factor (GEF) for Cdc42p genetic 1 1 1 Synthetic Rescue
COX6 YHR051W Subunit VI of cytochrome c oxidase (Complex IV) genetic 1 1 1 Negative Genetic
DRS2 YAL026C Trans-golgi network aminophospholipid translocase (flippase) genetic 1 1 1 Negative Genetic
CAF20 YOR276W Phosphoprotein of the mRNA cap-binding complex physical 1 1 1 Affinity Capture-RNA
FAR1 YJL157C CDK inhibitor and nuclear anchor genetic 1 1 1 Negative Genetic
DSS1 YMR287C 3'-5' exoribonuclease genetic 1 1 1 Negative Genetic
CDC4 YFL009W F-box protein required for both the G1/S and G2/M phase transitions physical 1 1 1 Reconstituted Complex
KIN82 YCR091W Putative serine/threonine protein kinase physical 1 1 1 Affinity Capture-MS
VHC1 YBR235W Vacuolar membrane cation-chloride cotransporter (CCC) physical 1 1 1 Affinity Capture-MS
HPR1 YDR138W Subunit of THO/TREX complexes physical 1 1 1 Affinity Capture-MS
PHO85 YPL031C Cyclin-dependent kinase physical 1 1 1 Biochemical Activity
PCL1 YNL289W Cyclin, interacts with cyclin-dependent kinase Pho85p physical 1 1 1 Biochemical Activity
PSK1 YAL017W PAS domain-containing serine/threonine protein kinase physical 1 1 1 Biochemical Activity
IRE1 YHR079C Serine-threonine kinase and endoribonuclease physical 1 1 1 Biochemical Activity
KSP1 YHR082C Serine/threonine protein kinase physical 1 1 1 Biochemical Activity
MCK1 YNL307C Dual-specificity ser/thr and tyrosine protein kinase physical 1 1 1 Biochemical Activity
PTK2 YJR059W Serine/threonine protein kinase physical 1 1 1 Biochemical Activity
RCK2 YLR248W Protein kinase involved in response to oxidative and osmotic stress physical 1 1 1 Biochemical Activity
YCK2 YNL154C Palmitoylated plasma membrane-bound casein kinase I (CK1) isoform physical 1 1 1 Biochemical Activity
HEK2 YBL032W RNA binding protein involved in asymmetric localization of ASH1 mRNA physical 1 1 1 Affinity Capture-RNA
WHI3 YNL197C RNA binding protein that modulates mRNA stability physical 1 1 1 Protein-RNA
IOC3 YFR013W Subunit of the Isw1a complex physical 1 1 1 Affinity Capture-MS
NUP157 YER105C Subunit of the inner ring of the nuclear pore complex (NPC) physical 1 1 1 Affinity Capture-MS
SOG2 YOR353C Key component of the RAM signaling network physical 1 1 1 Affinity Capture-MS
SYP1 YCR030C Negative regulator of WASP-Arp23 complex physical 1 1 1 Affinity Capture-MS
SBP1 YHL034C Protein that binds eIF4G and has a role in repression of translation physical 1 1 1 Affinity Capture-RNA
SSC1 YJR045C Hsp70 family ATPase physical 1 1 1 Affinity Capture-MS
PUF2 YPR042C PUF family mRNA-binding protein physical 1 1 1 Affinity Capture-RNA
HSP82 YPL240C Hsp90 chaperone physical 1 1 1 Affinity Capture-MS
RPB3 YIL021W RNA polymerase II third largest subunit B44 physical 1 1 1 Affinity Capture-MS
ISW1 YBR245C ATPase subunit of imitation-switch (ISWI) class chromatin remodelers physical 1 1 1 Affinity Capture-RNA
GIN4 YDR507C Protein kinase involved in bud growth and assembly of the septin ring physical 1 1 1 Biochemical Activity
HCS1 YKL017C Hexameric DNA polymerase alpha-associated DNA helicase A physical 1 1 1 Biochemical Activity
KNS1 YLL019C Protein kinase involved in negative regulation of PolIII transcription physical 1 1 1 Biochemical Activity
MAL33 YBR297W MAL-activator protein physical 1 1 1 Biochemical Activity
MDS3 YGL197W Putative component of the TOR regulatory pathway physical 1 1 1 Biochemical Activity
MDS3 YGL197W Putative component of the TOR regulatory pathway genetic 1 1 1 Positive Genetic
MTH1 YDR277C Negative regulator of the glucose-sensing signal transduction pathway physical 1 1 1 Biochemical Activity
MSN4 YKL062W Stress-responsive transcriptional activator physical 1 1 1 Biochemical Activity
NCS6 YGL211W Protein required for uridine thiolation of Gln, Lys, and Glu tRNAs physical 1 1 1 Biochemical Activity
NTG1 YAL015C DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase physical 1 1 1 Biochemical Activity
PTR3 YFR029W Component of the SPS plasma membrane amino acid sensor system physical 1 1 1 Biochemical Activity
RAD9 YDR217C DNA damage-dependent checkpoint protein physical 1 1 1 Biochemical Activity
SEG1 YMR086W Component of eisosome required for proper eisosome assembly physical 1 1 1 Biochemical Activity
SET1 YHR119W Histone methyltransferase, subunit of the COMPASS (Set1C) complex physical 1 1 1 Biochemical Activity
SLM2 YNL047C Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm1p physical 1 1 1 Biochemical Activity
SSO1 YPL232W Plasma membrane t-SNARE physical 1 1 1 Biochemical Activity
SSO2 YMR183C Plasma membrane t-SNARE physical 1 1 1 Biochemical Activity
TCB3 YML072C Cortical ER protein involved in ER-plasma membrane tethering physical 1 1 1 Biochemical Activity
TOG1 YER184C Transcriptional activator of oleate genes physical 1 1 1 Biochemical Activity
YPR003C YPR003C Putative sulfate permease physical 1 1 1 Biochemical Activity
YTA6 YPL074W Putative ATPase of the CDC48/PAS1/SEC18 (AAA) family physical 1 1 1 Biochemical Activity
PUB1 YNL016W Poly (A)+ RNA-binding protein physical 1 1 1 Affinity Capture-MS
SSD1 YDR293C Translational repressor physical 1 1 1 Affinity Capture-RNA
YPD1 YDL235C Osmotic stress-responsive phosphorelay intermediate sensor protein genetic 1 1 1 Positive Genetic
MNN10 YDR245W Subunit of a Golgi mannosyltransferase complex genetic 1 1 1 Positive Genetic
VPS72 YDR485C Htz1p-binding component of the SWR1 complex genetic 1 1 1 Positive Genetic
ISC1 YER019W Inositol phosphosphingolipid phospholipase C genetic 1 1 1 Positive Genetic
RPN10 YHR200W Proteasome polyubiquitin receptor genetic 1 1 1 Positive Genetic
PKP1 YIL042C Mitochondrial protein kinase genetic 1 1 1 Negative Genetic
SWI6 YLR182W Transcription cofactor genetic 1 1 1 Positive Genetic
YPT6 YLR262C Rab family GTPase genetic 1 1 1 Positive Genetic
SEC22 YLR268W R-SNARE protein genetic 1 1 1 Positive Genetic
VPS71 YML041C Nucleosome-binding component of the SWR1 complex genetic 1 1 1 Positive Genetic
SLN1 YIL147C Transmembrane histidine phosphotransfer kinase and osmosensor genetic 1 1 1 Positive Genetic
YPK2 YMR104C AGC-type S/T protein kinase genetic 1 1 1 Synthetic Rescue
HMO1 YDR174W Chromatin associated high mobility group (HMG) family member genetic 1 1 1 Negative Genetic
RRM3 YHR031C DNA helicase involved in rDNA replication and Ty1 transposition genetic 1 1 1 Negative Genetic
GRE3 YHR104W Aldose reductase genetic 1 1 1 Negative Genetic
UBR2 YLR024C Cytoplasmic ubiquitin-protein ligase (E3) genetic 1 1 1 Negative Genetic
TOF1 YNL273W Subunit of a replication-pausing checkpoint complex genetic 1 1 1 Negative Genetic
PSD1 YNL169C Phosphatidylserine decarboxylase of the mitochondrial inner membrane genetic 1 1 1 Positive Genetic
REI1 YBR267W Cytoplasmic pre-60S factor genetic 1 1 1 Negative Genetic
RSC2 YLR357W Component of the RSC chromatin remodeling complex genetic 1 1 1 Negative Genetic
RIM101 YHL027W Cys2His2 zinc-finger transcriptional repressor genetic 1 1 1 Negative Genetic
SKN7 YHR206W Nuclear response regulator and transcription factor genetic 1 1 1 Negative Genetic
TDA9 YML081W Transcription factor that regulates acetate production genetic 1 1 1 Negative Genetic
RAD17 YOR368W Checkpoint protein genetic 1 1 1 Positive Genetic
SSN8 YNL025C Cyclin-like component of RNA polymerase II holoenzyme genetic 1 1 1 Positive Genetic
SAT4 YCR008W Ser/Thr protein kinase involved in salt tolerance, nutrient response genetic 1 1 1 Positive Genetic
KCS1 YDR017C Inositol hexakisphosphate and inositol heptakisphosphate kinase genetic 1 1 1 Negative Genetic
NPL3 YDR432W RNA-binding protein genetic 1 1 1 Synthetic Rescue
TAF1 YGR274C TFIID subunit, involved in RNA pol II transcription initiation genetic 1 1 1 Synthetic Lethality
PAU21 YOR394W Protein of unknown function genetic 1 1 1 Dosage Growth Defect
YCT1 YLL055W High-affinity cysteine-specific transporter genetic 1 1 1 Dosage Growth Defect
STE50 YCL032W Adaptor protein for various signaling pathways genetic 1 1 1 Negative Genetic
KRE28 YDR532C Subunit of a kinetochore-microtubule binding complex genetic 1 1 1 Negative Genetic
YAP1 YML007W Basic leucine zipper (bZIP) transcription factor genetic 1 1 1 Synthetic Growth Defect
RPO21 YDL140C RNA polymerase II largest subunit B220 genetic 1 1 1 Synthetic Growth Defect
TOR2 YKL203C PIK-related protein kinase and rapamycin target genetic 1 1 1 Synthetic Rescue
ROM2 YLR371W Guanine nucleotide exchange factor (GEF) for Rho1p and Rho2p genetic 1 1 1 Phenotypic Suppression
GPI11 YDR302W ER membrane protein involved in a late step of GPI anchor assembly genetic 1 1 1 Positive Genetic
VPS54 YDR027C Component of the GARP (Golgi-associated retrograde protein) complex genetic 1 1 1 Positive Genetic
RPS8A YBL072C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Positive Genetic
NFS1 YCL017C Cysteine desulfurase involved in iron-sulfur cluster biogenesis genetic 1 1 1 Negative Genetic
FRQ1 YDR373W N-myristoylated calcium-binding protein genetic 1 1 1 Negative Genetic
KEG1 YFR042W Integral membrane protein of the ER genetic 1 1 1 Negative Genetic
RPL28 YGL103W Ribosomal 60S subunit protein L28 genetic 1 1 1 Negative Genetic
RAP1 YNL216W Essential DNA-binding transcription regulator that binds many loci genetic 1 1 1 Negative Genetic
RMD9 YGL107C Mitochondrial protein that controls mitochondrial gene expression genetic 1 1 1 Negative Genetic
YHR050W-A YHR050W-A Protein of unknown function genetic 1 1 1 Negative Genetic
RSM26 YJR101W Mitochondrial ribosomal protein of the small subunit genetic 1 1 1 Negative Genetic
ZWF1 YNL241C Glucose-6-phosphate dehydrogenase (G6PD) genetic 1 1 1 Negative Genetic
LTE1 YAL024C Protein similar to GDP/GTP exchange factors genetic 1 1 1 Negative Genetic
THR4 YCR053W Threonine synthase genetic 1 1 1 Negative Genetic
NUT1 YGL151W Component of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
RRD2 YPL152W Peptidyl-prolyl cis/trans-isomerase genetic 1 1 1 Negative Genetic
SUR1 YPL057C Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit genetic 1 1 1 Negative Genetic
VMA13 YPR036W Subunit H of the V1 peripheral membrane domain of V-ATPase genetic 1 1 1 Negative Genetic
SWI3 YJL176C Subunit of the SWI/SNF chromatin remodeling complex genetic 1 1 1 Negative Genetic
SIC1 YLR079W Cyclin-dependent kinase inhibitor (CKI) genetic 1 1 1 Positive Genetic
SSL2 YIL143C Component of RNA polymerase transcription factor TFIIH holoenzyme genetic 1 1 1 Positive Genetic
SRO7 YPR032W Effector of Rab GTPase Sec4p genetic 1 1 1 Positive Genetic
YNG1 YOR064C Subunit of the NuA3 histone acetyltransferase complex genetic 1 1 1 Negative Genetic
SIN3 YOL004W Component of both the Rpd3S and Rpd3L histone deacetylase complexes genetic 1 1 1 Negative Genetic
RTG3 YBL103C bHLH/Zip transcription factor for retrograde (RTG) and TOR pathways genetic 1 1 1 Negative Genetic
HOF1 YMR032W F-BAR protein that regulates actin cytoskeleton organization genetic 1 1 1 Synthetic Rescue
INN1 YNL152W Essential protein that associates with contractile actomyosin ring genetic 1 1 1 Synthetic Rescue
LSM1 YJL124C Lsm (Like Sm) protein genetic 1 1 1 Positive Genetic
PAT1 YCR077C Deadenylation-dependent mRNA-decapping factor genetic 1 1 1 Positive Genetic
EXO70 YJL085W Subunit of the exocyst complex genetic 1 1 1 Negative Genetic
CTK3 YML112W Gamma subunit of C-terminal domain kinase I genetic 1 1 1 Positive Genetic
DCK1 YLR422W Dock family protein (Dedicator Of CytoKinesis), homolog of human DOCK1 genetic 1 1 1 Positive Genetic
ATG13 YPR185W Regulatory subunit of the Atg1p signaling complex physical 1 1 1 Biochemical Activity
AFT1 YGL071W Transcription factor involved in iron utilization and homeostasis genetic 1 1 1 Positive Genetic
ART5 YGR068C Protein proposed to regulate endocytosis of plasma membrane proteins genetic 1 1 1 Dosage Rescue
COG4 YPR105C Essential component of the conserved oligomeric Golgi complex genetic 1 1 1 Positive Genetic
DAL81 YIR023W Positive regulator of genes in multiple nitrogen degradation pathways genetic 1 1 1 Negative Genetic
CBF1 YJR060W Basic helix-loop-helix (bHLH) protein genetic 1 1 1 Negative Genetic
BUB1 YGR188C Protein kinase involved in the cell cycle checkpoint into anaphase genetic 1 1 1 Positive Genetic
ELO2 YCR034W Fatty acid elongase, involved in sphingolipid biosynthesis genetic 1 1 1 Negative Genetic
BNR1 YIL159W Formin genetic 1 1 1 Positive Genetic
CLA4 YNL298W Cdc42p-activated signal transducing kinase genetic 1 1 1 Negative Genetic
BTS1 YPL069C Geranylgeranyl diphosphate synthase (GGPPS) genetic 1 1 1 Positive Genetic
DCC1 YCL016C Subunit of a complex with Ctf8p and Ctf18p genetic 1 1 1 Negative Genetic
CYK3 YDL117W SH3-domain protein located in the bud neck and cytokinetic actin ring genetic 1 1 1 Synthetic Rescue
DNF1 YER166W Aminophospholipid translocase (flippase) physical 1 1 1 Biochemical Activity
DNF1 YER166W Aminophospholipid translocase (flippase) genetic 1 1 1 Synthetic Rescue
ARV1 YLR242C Cortical ER protein genetic 1 1 1 Negative Genetic
DNF2 YDR093W Aminophospholipid translocase (flippase) physical 1 1 1 Biochemical Activity
DNF2 YDR093W Aminophospholipid translocase (flippase) genetic 1 1 1 Synthetic Rescue
DNF3 YMR162C Trans-golgi network aminophospholipid translocase (flippase) physical 1 1 1 Biochemical Activity
DNF3 YMR162C Trans-golgi network aminophospholipid translocase (flippase) genetic 1 1 1 Phenotypic Enhancement
CRD1 YDL142C Cardiolipin synthase genetic 1 1 1 Negative Genetic
AGP1 YCL025C Broad-specificity, low-affinity amino acid permease genetic 1 1 1 Negative Genetic