Standard name Systematic name Name description Description
HRT1 YOL133W RING-H2 domain core subunit of multiple ubiquitin ligase complexes RING-H2 domain core subunit of multiple ubiquitin ligase complexes; subunit of Skp1-Cullin-F-box (SCF) that tethers the Cdc34p (E2) and Cdc53p (cullin) SCF subunits, and is required for degradation of Gic2p, Far1p, Sic1p and Cln2p; subunit of the Rtt101p-Mms1p-Mms22p ubiquitin ligase that stabilizes replication forks after DNA lesions; subunit of the Cul3p-Elc1p-Ela1p ubiquitin ligase involved in Rpb1p degradation as part of transcription-coupled repair
Visualize the interactome of HRT1
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
no data no data no data

GFP localization & abundance

GFP localization GFP abundance
no data no data

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
HRT1 3 1 0 0 0

Enzyme information

Catalyzed reactions in Yeast8

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
CDC34 YDR054C Ubiquitin-conjugating enzyme (E2) physical 19 4 17 Affinity Capture-Western, FRET, Co-crystal Structure, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex
CDC53 YDL132W Cullin physical 17 6 12 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Co-purification, Reconstituted Complex, Affinity Capture-Western, Two-hybrid, Reconstituted Complex, Co-purification, Biochemical Activity
CDC4 YFL009W F-box protein required for both the G1/S and G2/M phase transitions physical 7 3 6 Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Two-hybrid, Reconstituted Complex, Affinity Capture-Western, Reconstituted Complex
SKP1 YDR328C Evolutionarily conserved kinetochore protein physical 4 2 4 Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS
RTT101 YJL047C Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex physical 4 3 3 Affinity Capture-MS, Two-hybrid, Affinity Capture-Western, Two-hybrid
GRR1 YJR090C F-box protein component of an SCF ubiquitin-ligase complex physical 4 3 3 Affinity Capture-Western, Two-hybrid, Two-hybrid, Reconstituted Complex
LAG2 YOL025W Protein that negatively regulates the SCF E3-ubiquitin ligase physical 3 3 2 Affinity Capture-Western, Reconstituted Complex, Co-purification
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 2 1 2 Affinity Capture-RNA, Affinity Capture-RNA
MET30 YIL046W F-box protein containing five copies of the WD40 motif physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
MMS1 YPR164W Subunit of E3 ubiquitin ligase complex involved in replication repair physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
UBC12 YLR306W Enzyme that mediates the conjugation of Rub1p physical 2 1 2 Reconstituted Complex, Reconstituted Complex
UBC4 YBR082C Ubiquitin-conjugating enzyme (E2) physical 2 1 2 Reconstituted Complex, Reconstituted Complex
UBC5 YDR059C Ubiquitin-conjugating enzyme physical 2 1 2 Reconstituted Complex, Reconstituted Complex
SIC1 YLR079W Cyclin-dependent kinase inhibitor (CKI) genetic 2 1 2 Dosage Lethality, Dosage Lethality
CDC53 YDL132W Cullin genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
CLN2 YPL256C G1 cyclin involved in regulation of the cell cycle genetic 2 1 2 Dosage Lethality, Dosage Lethality
DCN1 YLR128W Scaffold-type E3 ligase physical 2 1 2 Reconstituted Complex, Reconstituted Complex
CUL3 YGR003W Ubiquitin-protein ligase physical 2 1 2 Two-hybrid, Two-hybrid
CDC34 YDR054C Ubiquitin-conjugating enzyme (E2) genetic 2 2 1 Dosage Rescue, Synthetic Lethality
SFP1 YLR403W Regulates transcription of ribosomal protein and biogenesis genes regulation 1 1 1 DNA to cDNA expression microarray evidence
XBP1 YIL101C Transcriptional repressor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
YAP6 YDR259C Basic leucine zipper (bZIP) transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CDC42 YLR229C Small rho-like GTPase genetic 1 1 1 Synthetic Growth Defect
ACT1 YFL039C Actin, structural protein in cytoskeleton genetic 1 1 1 Synthetic Growth Defect
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
CDC39 YCR093W Subunit of the CCR4-NOT1 core complex physical 1 1 1 Affinity Capture-MS
APC2 YLR127C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) physical 1 1 1 Two-hybrid
ARP2 YDL029W Essential component of the Arp2/3 complex genetic 1 1 1 Synthetic Lethality
CDC12 YHR107C Component of the septin ring that is required for cytokinesis genetic 1 1 1 Synthetic Growth Defect
GCN1 YGL195W Positive regulator of the Gcn2p kinase activity physical 1 1 1 Affinity Capture-MS
HSH49 YOR319W U2-snRNP associated splicing factor physical 1 1 1 Affinity Capture-MS
MKT1 YNL085W Protein similar to nucleases that forms a complex with Pbp1p physical 1 1 1 Affinity Capture-MS
TPS1 YBR126C Synthase subunit of trehalose-6-P synthase/phosphatase complex physical 1 1 1 Affinity Capture-MS
HYP2 YEL034W Translation elongation factor eIF-5A physical 1 1 1 Affinity Capture-MS
REA1 YLR106C Huge dynein-related AAA-type ATPase (midasin) physical 1 1 1 Affinity Capture-MS
VPS13 YLL040C Lipid transport protein involved in prospore membrane morphogenesis physical 1 1 1 Affinity Capture-MS
RPA190 YOR341W RNA polymerase I largest subunit A190 physical 1 1 1 Affinity Capture-MS
RPN1 YHR027C Non-ATPase base subunit of the 19S RP of the 26S proteasome physical 1 1 1 Affinity Capture-MS
PMA2 YPL036W Plasma membrane H+-ATPase physical 1 1 1 Affinity Capture-MS
YAR009C YAR009C Retrotransposon TYA Gag and TYB Pol genes physical 1 1 1 Affinity Capture-MS
YGP1 YNL160W Cell wall-related secretory glycoprotein physical 1 1 1 Affinity Capture-MS
MYO2 YOR326W Type V myosin motor involved in actin-based transport of cargos physical 1 1 1 Affinity Capture-MS
UBI4 YLL039C Ubiquitin physical 1 1 1 Affinity Capture-MS
PFK1 YGR240C Alpha subunit of heterooctameric phosphofructokinase physical 1 1 1 Affinity Capture-MS
YLR035C-A YLR035C-A Retrotransposon TYA Gag and TYB Pol genes physical 1 1 1 Affinity Capture-MS
RPN8 YOR261C Essential non-ATPase regulatory subunit of the 26S proteasome physical 1 1 1 Affinity Capture-MS
SEC27 YGL137W Essential beta'-coat protein of the COPI coatomer physical 1 1 1 Affinity Capture-MS
RIX7 YLL034C Putative ATPase of the AAA family physical 1 1 1 Affinity Capture-MS
IDH1 YNL037C Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase physical 1 1 1 Affinity Capture-MS
YAK1 YJL141C Serine-threonine protein kinase physical 1 1 1 Two-hybrid
YIL001W YIL001W Putative protein of unknown function physical 1 1 1 Two-hybrid
UFO1 YML088W F-box receptor protein physical 1 1 1 Reconstituted Complex
HRT3 YLR097C Putative SCF-ubiquitin ligase F-box protein physical 1 1 1 Reconstituted Complex
YDR131C YDR131C F-box protein subunit of SCF ubiquitin ligase complex physical 1 1 1 Reconstituted Complex
RCY1 YJL204C F-box protein involved in recycling endocytosed proteins physical 1 1 1 Reconstituted Complex
UCC1 YLR224W F-box protein and component of SCF ubiquitin ligase complexes physical 1 1 1 Reconstituted Complex
PFU1 YDR306C F-box protein that regulates pheromone-dependent morphogenesis physical 1 1 1 Reconstituted Complex
SKP2 YNL311C F-box protein of unknown function physical 1 1 1 Reconstituted Complex
MDM30 YLR368W F-box component of an SCF ubiquitin protein ligase complex physical 1 1 1 Reconstituted Complex
UBX5 YDR330W UBX domain-containing protein that interacts with Cdc48p physical 1 1 1 Two-hybrid
YBP2 YGL060W Central kinetochore associated protein physical 1 1 1 Two-hybrid
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-RNA
SAF1 YBR280C F-Box protein involved in proteasome-dependent degradation of Aah1p physical 1 1 1 Affinity Capture-Western
MCM4 YPR019W Essential helicase component of heterohexameric MCM2-7 complexes physical 1 1 1 Affinity Capture-Western
SLD5 YDR489W Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) physical 1 1 1 Affinity Capture-Western
TFB3 YDR460W Subunit of TFIIH and nucleotide excision repair factor 3 complexes physical 1 1 1 Reconstituted Complex
SRO9 YCL037C Cytoplasmic RNA-binding protein physical 1 1 1 Affinity Capture-RNA
SBP1 YHL034C Protein that binds eIF4G and has a role in repression of translation physical 1 1 1 Affinity Capture-RNA
NAM7 YMR080C ATP-dependent RNA helicase of the SFI superfamily physical 1 1 1 Affinity Capture-RNA
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
MMS22 YLR320W Subunit of E3 ubiquitin ligase complex involved in replication repair physical 1 1 1 Affinity Capture-MS
PUB1 YNL016W Poly (A)+ RNA-binding protein physical 1 1 1 Affinity Capture-MS
SMC6 YLR383W Subunit of the SMC5-SMC6 complex physical 1 1 1 Affinity Capture-MS
SEC15 YGL233W Essential 113 kDa subunit of the exocyst complex genetic 1 1 1 Synthetic Lethality
SEC18 YBR080C AAA ATPase and SNARE disassembly chaperone genetic 1 1 1 Synthetic Lethality
MAD1 YGL086W Coiled-coil protein involved in spindle-assembly checkpoint genetic 1 1 1 Synthetic Lethality
MRE11 YMR224C Nuclease subunit of the MRX complex with Rad50p and Xrs2p genetic 1 1 1 Synthetic Lethality
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 1 1 1 Synthetic Lethality
RTT107 YHR154W BRCA1 C-terminal domain protein needed for recovery from DNA damage genetic 1 1 1 Negative Genetic
ECM29 YHL030W Scaffold protein physical 1 1 1 Affinity Capture-MS
CRM1 YGR218W Nuclear export factor, exportin physical 1 1 1 Affinity Capture-MS
CMR1 YDL156W Nuclear protein with role in transcription, protein quality control physical 1 1 1 Affinity Capture-MS
ARP8 YOR141C Nuclear actin-related protein involved in chromatin remodeling genetic 1 1 1 Negative Genetic
DUR12 YBR208C Urea amidolyase physical 1 1 1 Affinity Capture-MS
BBC1 YJL020C Protein possibly involved in assembly of actin patches physical 1 1 1 Affinity Capture-MS
ADR1 YDR216W Carbon source-responsive zinc-finger transcription factor physical 1 1 1 Affinity Capture-MS
GRR1 YJR090C F-box protein component of an SCF ubiquitin-ligase complex genetic 1 1 1 Synthetic Lethality
FAA4 YMR246W Long chain fatty acyl-CoA synthetase physical 1 1 1 Affinity Capture-MS
ELM1 YKL048C Serine/threonine protein kinase genetic 1 1 1 Dosage Growth Defect
GUF1 YLR289W Mitochondrial matrix GTPase physical 1 1 1 Affinity Capture-MS
DAS1 YJL149W Putative SCF ubiquitin ligase F-box protein physical 1 1 1 Reconstituted Complex
CTF13 YMR094W Subunit of the CBF3 complex physical 1 1 1 Reconstituted Complex
DIA2 YOR080W Origin-binding F-box protein physical 1 1 1 Reconstituted Complex
GAL3 YDR009W Transcriptional regulator physical 1 1 1 Affinity Capture-MS
ECM33 YBR078W GPI-anchored protein involved in efficient glucose uptake physical 1 1 1 Affinity Capture-MS
ACO2 YJL200C Putative mitochondrial aconitase isozyme physical 1 1 1 Two-hybrid
GIS2 YNL255C Translational activator for mRNAs with internal ribosome entry sites physical 1 1 1 Affinity Capture-RNA
CRT10 YOL063C Protein required for the degradation of mutant 25S rRNAs physical 1 1 1 Affinity Capture-MS