Standard name Systematic name Name description Description
HSM3 YBR272C Evolutionarily conserved 19S regulatory particle assembly-chaperone Evolutionarily conserved 19S regulatory particle assembly-chaperone; involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); involved in DNA mismatch repair during slow growth; weak similarity to Msh1p; structural study suggests Hsm3p is a scaffold protein for Rpt1p-Rpt2p complex formation; ortholog of human 19S subunit S5b
Visualize the interactome of HSM3
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.985 0.968 0.987
Mito NaN NaN 0.124

GFP localization & abundance

GFP localization GFP abundance
cytoplasm 468

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
HSM3 1 0 0 0 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
RPT1 YKL145W ATPase of the 19S regulatory particle of the 26S proteasome physical 19 6 10 Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Two-hybrid, Affinity Capture-Western, Two-hybrid, Two-hybrid, Co-purification, Co-crystal Structure, Reconstituted Complex, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Reconstituted Complex, Affinity Capture-Western
RPT5 YOR117W ATPase of the 19S regulatory particle of the 26S proteasome physical 9 4 8 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Two-hybrid, Affinity Capture-Western, Affinity Capture-MS, Reconstituted Complex
RPN1 YHR027C Non-ATPase base subunit of the 19S RP of the 26S proteasome physical 6 4 6 Affinity Capture-Western, Affinity Capture-Western, Co-purification, Co-purification, Affinity Capture-MS, Reconstituted Complex
RPT3 YDR394W ATPase of the 19S regulatory particle of the 26S proteasome physical 6 3 6 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Reconstituted Complex
NAS2 YIL007C Evolutionarily conserved 19S regulatory particle assembly-chaperone genetic 6 2 4 Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Enhancement
RPN14 YGL004C Evolutionarily conserved 19S regulatory particle assembly-chaperone genetic 6 3 3 Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Rescue, Synthetic Growth Defect
RPT2 YDL007W ATPase of the 19S regulatory particle of the 26S proteasome physical 5 3 5 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-MS
RPN9 YDR427W Non-ATPase regulatory subunit of the 26S proteasome physical 5 2 5 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS
RPT6 YGL048C ATPase of the 19S regulatory particle of the 26S proteasome physical 5 2 5 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS
RPN8 YOR261C Essential non-ATPase regulatory subunit of the 26S proteasome physical 5 3 4 Affinity Capture-MS, Affinity Capture-Western, Co-fractionation, Affinity Capture-Western, Affinity Capture-MS
RPN14 YGL004C Evolutionarily conserved 19S regulatory particle assembly-chaperone physical 5 3 4 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Reconstituted Complex, Reconstituted Complex
NAS6 YGR232W Evolutionarily conserved 19S regulatory particle assembly-chaperone genetic 5 3 3 Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Rescue, Synthetic Growth Defect
RPN6 YDL097C Essential, non-ATPase regulatory subunit of the 26S proteasome lid physical 4 2 4 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS
RPN5 YDL147W Subunit of the CSN and 26S proteasome lid complexes physical 4 2 4 Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS
RPN4 YDL020C Transcription factor that stimulates expression of proteasome genes genetic 4 2 4 Negative Genetic, Synthetic Lethality, Negative Genetic, Negative Genetic
NAS6 YGR232W Evolutionarily conserved 19S regulatory particle assembly-chaperone physical 4 3 3 Affinity Capture-Western, Affinity Capture-MS, Reconstituted Complex, Reconstituted Complex
RPN12 YFR052W Subunit of the 19S regulatory particle of the 26S proteasome lid physical 3 2 3 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS
RPN3 YER021W Essential non-ATPase regulatory subunit of the 26S proteasome lid physical 3 2 3 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS
RPT1 YKL145W ATPase of the 19S regulatory particle of the 26S proteasome genetic 3 2 3 Dosage Rescue, Dosage Rescue, Negative Genetic
RPT4 YOR259C ATPase of the 19S regulatory particle of the 26S proteasome physical 3 2 3 Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS
ECM29 YHL030W Scaffold protein genetic 3 3 2 Phenotypic Suppression, Synthetic Rescue, Synthetic Growth Defect
UBP6 YFR010W Ubiquitin-specific protease genetic 3 3 1 Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Lethality
RPT2 YDL007W ATPase of the 19S regulatory particle of the 26S proteasome genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
RPT3 YDR394W ATPase of the 19S regulatory particle of the 26S proteasome genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
RPN11 YFR004W Metalloprotease subunit of 19S regulatory particle physical 2 2 2 Affinity Capture-Western, Affinity Capture-MS
RPN10 YHR200W Proteasome polyubiquitin receptor physical 2 2 2 Affinity Capture-Western, Affinity Capture-MS
RPN2 YIL075C Subunit of the 26S proteasome physical 2 2 2 Affinity Capture-Western, Affinity Capture-MS
RPN7 YPR108W Essential non-ATPase regulatory subunit of the 26S proteasome physical 2 2 2 Affinity Capture-Western, Affinity Capture-MS
PMS1 YNL082W ATP-binding protein required for mismatch repair genetic 2 2 2 Phenotypic Suppression, Phenotypic Enhancement
RPT5 YOR117W ATPase of the 19S regulatory particle of the 26S proteasome genetic 2 1 2 Synthetic Growth Defect, Synthetic Growth Defect
RAD2 YGR258C Single-stranded DNA endonuclease genetic 2 1 2 Phenotypic Enhancement, Phenotypic Enhancement
REV3 YPL167C Catalytic subunit of DNA polymerase zeta genetic 2 1 2 Phenotypic Suppression, Phenotypic Suppression
PRE10 YOR362C Alpha 7 subunit of the 20S proteasome physical 2 2 1 Affinity Capture-Western, Co-fractionation
FKH1 YIL131C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CDC73 YLR418C Component of the Paf1p complex genetic 1 1 1 Positive Genetic
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
APL6 YGR261C Beta3-like subunit of the yeast AP-3 complex genetic 1 1 1 Negative Genetic
ASC1 YMR116C G-protein beta subunit and guanine dissociation inhibitor for Gpa2p physical 1 1 1 Proximity Label-MS
CAF40 YNL288W Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-MS
COX5A YNL052W Subunit Va of cytochrome c oxidase genetic 1 1 1 Negative Genetic
HAT1 YPL001W Catalytic subunit of the Hat1p-Hat2p histone acetyltransferase complex physical 1 1 1 Affinity Capture-MS
HAT2 YEL056W Subunit of the Hat1p-Hat2p histone acetyltransferase complex physical 1 1 1 Affinity Capture-MS
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
HHF2 YNL030W Histone H4 physical 1 1 1 Affinity Capture-MS
HIF1 YLL022C Non-essential component of the HAT-B histone acetyltransferase complex physical 1 1 1 Affinity Capture-MS
PSH1 YOL054W E3 ubiquitin ligase targeting centromere-binding protein Cse4p physical 1 1 1 Affinity Capture-MS
KSS1 YGR040W Mitogen-activated protein kinase (MAPK) physical 1 1 1 Biochemical Activity
SEM1 YDR363W-A 19S proteasome regulatory particle lid subcomplex component physical 1 1 1 Affinity Capture-Western
PRE2 YPR103W Beta 5 subunit of the 20S proteasome physical 1 1 1 Affinity Capture-Western
SCL1 YGL011C Alpha 1 subunit of the 20S proteasome physical 1 1 1 Affinity Capture-Western
ORC1 YML065W Largest subunit of the origin recognition complex physical 1 1 1 Affinity Capture-MS
HSM3 YBR272C Evolutionarily conserved 19S regulatory particle assembly-chaperone physical 1 1 1 Affinity Capture-MS
RPN13 YLR421C Subunit of the 19S regulatory particle of the 26S proteasome lid physical 1 1 1 Affinity Capture-MS
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
SGS1 YMR190C RecQ family nucleolar DNA helicase physical 1 1 1 Affinity Capture-MS
RAD1 YPL022W Single-stranded DNA endonuclease (with Rad10p) genetic 1 1 1 Phenotypic Enhancement
RAD14 YMR201C Subunit of Nucleotide Excision Repair Factor 1 (NEF1) genetic 1 1 1 Phenotypic Enhancement
POL30 YBR088C Proliferating cell nuclear antigen (PCNA) genetic 1 1 1 Phenotypic Suppression
POL2 YNL262W Catalytic subunit of DNA polymerase (II) epsilon genetic 1 1 1 Phenotypic Suppression
SAE3 YHR079C-A Meiosis-specific protein involved in meiotic recombination genetic 1 1 1 Negative Genetic
SPF1 YEL031W P-type ATPase, ion transporter of the ER membrane genetic 1 1 1 Negative Genetic
SIC1 YLR079W Cyclin-dependent kinase inhibitor (CKI) genetic 1 1 1 Negative Genetic
RTG1 YOL067C Transcription factor (bHLH) involved in interorganelle communication genetic 1 1 1 Negative Genetic
NUP84 YDL116W Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) genetic 1 1 1 Positive Genetic
THP1 YOL072W Nuclear pore-associated protein genetic 1 1 1 Positive Genetic
PFD1 YJL179W Subunit of heterohexameric prefoldin genetic 1 1 1 Positive Genetic
KAR2 YJL034W ATPase involved in protein import into the ER genetic 1 1 1 Positive Genetic
POL3 YDL102W Catalytic subunit of DNA polymerase delta genetic 1 1 1 Phenotypic Enhancement
PGU1 YJR153W Endo-polygalacturonase genetic 1 1 1 Phenotypic Enhancement
RAD18 YCR066W E3 ubiquitin ligase genetic 1 1 1 Phenotypic Suppression
MMS2 YGL087C Ubiquitin-conjugating enzyme variant genetic 1 1 1 Phenotypic Suppression
SRS2 YJL092W DNA helicase and DNA-dependent ATPase genetic 1 1 1 Phenotypic Suppression
NPL3 YDR432W RNA-binding protein genetic 1 1 1 Synthetic Rescue
YKU70 YMR284W Subunit of the telomeric Ku complex (Yku70p-Yku80p) genetic 1 1 1 Negative Genetic
PLN1 YKR046C Perilipin, involved in formation and stability of lipid droplets genetic 1 1 1 Positive Genetic
IZH2 YOL002C Plasma membrane receptor for plant antifungal osmotin genetic 1 1 1 Positive Genetic
TIF11 YMR260C Translation initiation factor eIF1A genetic 1 1 1 Negative Genetic
SMX3 YPR182W Core Sm protein Sm F genetic 1 1 1 Negative Genetic
KAP104 YBR017C Transportin or cytosolic karyopherin beta 2 genetic 1 1 1 Negative Genetic
URA7 YBL039C Major CTP synthase isozyme (see also URA8) genetic 1 1 1 Negative Genetic
PIN4 YBL051C Protein involved in G2/M phase progression and response to DNA damage genetic 1 1 1 Negative Genetic
RPL23A YBL087C Ribosomal 60S subunit protein L23A genetic 1 1 1 Negative Genetic
RPS14A YCR031C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
SNT1 YCR033W Set3C histone deacetylase scaffold genetic 1 1 1 Negative Genetic
RPL41A YDL184C Ribosomal 60S subunit protein L41A genetic 1 1 1 Negative Genetic
RRP8 YDR083W Nucleolar S-adenosylmethionine-dependent rRNA methyltransferase genetic 1 1 1 Negative Genetic
MRPL1 YDR116C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
RPA14 YDR156W RNA polymerase I subunit A14 genetic 1 1 1 Negative Genetic
VPS72 YDR485C Htz1p-binding component of the SWR1 complex genetic 1 1 1 Negative Genetic
MIL1 YFL034W Predicted lipase genetic 1 1 1 Negative Genetic
RPS23A YGR118W Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
YTA7 YGR270W Chromatin-binding ATPase that regulates histone gene expression genetic 1 1 1 Negative Genetic
PIH1 YHR034C Component of the conserved R2TP complex (Rvb1-Rvb2-Tah1-Pih1) genetic 1 1 1 Negative Genetic
PHO86 YJL117W Endoplasmic reticulum (ER) resident protein genetic 1 1 1 Negative Genetic
UTH1 YKR042W Mitochondrial inner membrane protein genetic 1 1 1 Negative Genetic
MMR1 YLR190W Phosphorylated protein of the mitochondrial outer membrane genetic 1 1 1 Negative Genetic
PET8 YNL003C S-adenosylmethionine transporter of the mitochondrial inner membrane genetic 1 1 1 Negative Genetic
MSC6 YOR354C Multicopy suppressor of HER2 involved in mitochondrial translation genetic 1 1 1 Negative Genetic
KAR3 YPR141C Minus-end-directed microtubule motor genetic 1 1 1 Negative Genetic
QCR2 YPR191W Subunit 2 of ubiquinol cytochrome-c reductase (Complex III) genetic 1 1 1 Negative Genetic
MSS116 YDR194C Mitochondrial transcription elongation factor genetic 1 1 1 Negative Genetic
MDM32 YOR147W Mitochondrial inner membrane protein with similarity to Mdm31p genetic 1 1 1 Negative Genetic
MOT2 YER068W Ubiquitin-protein ligase subunit of the CCR4-NOT complex genetic 1 1 1 Synthetic Rescue
HSP42 YDR171W Small heat shock protein (sHSP) with chaperone activity genetic 1 1 1 Phenotypic Suppression
HMO1 YDR174W Chromatin associated high mobility group (HMG) family member genetic 1 1 1 Phenotypic Enhancement
CIN8 YEL061C Bipolar kinesin motor protein genetic 1 1 1 Positive Genetic
BIR1 YJR089W Subunit of chromosomal passenger complex (CPC) genetic 1 1 1 Negative Genetic
ASI3 YNL008C Subunit of the inner nuclear membrane Asi ubiquitin ligase complex genetic 1 1 1 Negative Genetic
ACF4 YJR083C Protein of unknown function genetic 1 1 1 Negative Genetic
HRB1 YNL004W Poly(A+) RNA-binding protein genetic 1 1 1 Positive Genetic
BPT1 YLL015W ABC type transmembrane transporter of MRP/CFTR family genetic 1 1 1 Negative Genetic
ARK1 YNL020C Ser/Thr protein kinase genetic 1 1 1 Negative Genetic
DPH5 YLR172C Methyltransferase required for synthesis of diphthamide genetic 1 1 1 Negative Genetic
DIA1 YMR316W Protein of unknown function genetic 1 1 1 Negative Genetic
COQ2 YNR041C Para hydroxybenzoate polyprenyl transferase genetic 1 1 1 Positive Genetic
ERG3 YLR056W C-5 sterol desaturase genetic 1 1 1 Negative Genetic
AVT5 YBL089W Putative transporter genetic 1 1 1 Negative Genetic
HIM1 YDR317W Protein of unknown function involved in DNA repair genetic 1 1 1 Phenotypic Enhancement