CDC20 |
YGL116W |
Activator of anaphase-promoting complex/cyclosome (APC/C) |
physical |
19 |
5 |
12 |
Two-hybrid, Affinity Capture-Western, Affinity Capture-Western, Two-hybrid, Two-hybrid, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Co-fractionation, Reconstituted Complex, Co-purification, Affinity Capture-Western, Affinity Capture-Western, Two-hybrid, Two-hybrid, Reconstituted Complex, Affinity Capture-Western, Two-hybrid, Affinity Capture-Western |
CTF19 |
YPL018W |
Outer kinetochore protein, needed for accurate chromosome segregation |
genetic |
11 |
3 |
10 |
Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
CTF18 |
YMR078C |
Subunit of a complex with Ctf8p |
genetic |
11 |
4 |
9 |
Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Phenotypic Suppression, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic |
CIN8 |
YEL061C |
Bipolar kinesin motor protein |
genetic |
11 |
3 |
9 |
Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Lethality, Phenotypic Suppression, Negative Genetic |
BIM1 |
YER016W |
Microtubule plus end-tracking protein |
genetic |
11 |
3 |
9 |
Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic |
CHL4 |
YDR254W |
Outer kinetochore protein required for chromosome stability |
genetic |
11 |
3 |
8 |
Synthetic Growth Defect, Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
CHL1 |
YPL008W |
Probable DNA helicase |
genetic |
11 |
3 |
8 |
Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic |
CTF8 |
YHR191C |
Subunit of a complex with Ctf18p |
genetic |
11 |
3 |
8 |
Synthetic Growth Defect, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic |
CIN1 |
YOR349W |
Tubulin folding factor D involved in beta-tubulin (Tub2p) folding |
genetic |
11 |
3 |
8 |
Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
KAR3 |
YPR141C |
Minus-end-directed microtubule motor |
genetic |
11 |
2 |
8 |
Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
YKE2 |
YLR200W |
Subunit of the heterohexameric Gim/prefoldin protein complex |
genetic |
11 |
3 |
7 |
Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
CIN2 |
YPL241C |
GTPase-activating protein (GAP) for Cin4p |
genetic |
11 |
3 |
7 |
Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
MCM21 |
YDR318W |
Component of the kinetochore sub-complex COMA |
genetic |
10 |
2 |
8 |
Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
GIM3 |
YNL153C |
Subunit of the heterohexameric cochaperone prefoldin complex |
genetic |
10 |
3 |
7 |
Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
CTF3 |
YLR381W |
Outer kinetochore protein that forms a complex with Mcm16p and Mcm22p |
genetic |
9 |
3 |
8 |
Synthetic Growth Defect, Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic |
MCM16 |
YPR046W |
Component of the Ctf19 complex and the COMA subcomplex |
genetic |
9 |
3 |
8 |
Synthetic Growth Defect, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic |
HCM1 |
YCR065W |
Forkhead transcription factor |
genetic |
9 |
3 |
8 |
Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic |
SLK19 |
YOR195W |
Kinetochore-associated protein |
genetic |
9 |
3 |
7 |
Synthetic Growth Defect, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic |
DCC1 |
YCL016C |
Subunit of a complex with Ctf8p and Ctf18p |
genetic |
9 |
3 |
7 |
Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic |
MAD1 |
YGL086W |
Coiled-coil protein involved in spindle-assembly checkpoint |
physical |
9 |
6 |
5 |
Affinity Capture-Western, Affinity Capture-Western, Two-hybrid, Affinity Capture-Western, Co-fractionation, Affinity Capture-MS, Reconstituted Complex, Co-purification, Affinity Capture-Western |
VPS72 |
YDR485C |
Htz1p-binding component of the SWR1 complex |
genetic |
8 |
3 |
6 |
Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic |
IML3 |
YBR107C |
Outer kinetochore protein and component of the Ctf19 complex |
genetic |
7 |
3 |
7 |
Synthetic Growth Defect, Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic |
CTF4 |
YPR135W |
Chromatin-associated protein |
genetic |
7 |
3 |
6 |
Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic |
CIK1 |
YMR198W |
Kinesin-associated protein |
genetic |
7 |
3 |
6 |
Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Phenotypic Suppression, Negative Genetic |
MCM22 |
YJR135C |
Outer kinetochore protein and component of the Ctf3 subcomplex |
genetic |
7 |
3 |
6 |
Synthetic Growth Defect, Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect |
GIM4 |
YEL003W |
Subunit of the heterohexameric cochaperone prefoldin complex |
genetic |
7 |
3 |
6 |
Synthetic Lethality, Synthetic Growth Defect, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect |
GIM5 |
YML094W |
Subunit of the heterohexameric cochaperone prefoldin complex |
genetic |
7 |
2 |
6 |
Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic |
PAC10 |
YGR078C |
Part of the heteromeric co-chaperone GimC/prefoldin complex |
genetic |
7 |
3 |
5 |
Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic |
HTZ1 |
YOL012C |
Histone variant H2AZ |
genetic |
6 |
3 |
6 |
Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic |
YBP2 |
YGL060W |
Central kinetochore associated protein |
genetic |
6 |
3 |
5 |
Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Phenotypic Enhancement, Negative Genetic, Negative Genetic |
SSE1 |
YPL106C |
ATPase component of heat shock protein Hsp90 chaperone complex |
genetic |
6 |
3 |
5 |
Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic |
TUB4 |
YLR212C |
Gamma-tubulin |
genetic |
6 |
3 |
5 |
Synthetic Lethality, Synthetic Growth Defect, Synthetic Lethality, Negative Genetic, Synthetic Lethality, Synthetic Growth Defect |
TUB3 |
YML124C |
Alpha-tubulin |
genetic |
6 |
2 |
5 |
Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
IRC15 |
YPL017C |
Microtubule associated protein |
genetic |
6 |
2 |
4 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
DAM1 |
YGR113W |
Essential subunit of the Dam1 complex (aka DASH complex) |
genetic |
5 |
3 |
5 |
Synthetic Lethality, Negative Genetic, Dosage Rescue, Negative Genetic, Negative Genetic |
BUB2 |
YMR055C |
Mitotic exit network regulator |
genetic |
5 |
3 |
5 |
Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Suppression, Phenotypic Enhancement |
TUB2 |
YFL037W |
Beta-tubulin |
genetic |
5 |
3 |
5 |
Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Synthetic Lethality |
STU1 |
YBL034C |
Microtubule plus-end-tracking non-motor protein |
genetic |
5 |
3 |
5 |
Synthetic Lethality, Phenotypic Suppression, Negative Genetic, Negative Genetic, Negative Genetic |
CLB2 |
YPR119W |
B-type cyclin involved in cell cycle progression |
genetic |
5 |
4 |
4 |
Synthetic Lethality, Phenotypic Suppression, Phenotypic Suppression, Positive Genetic, Negative Genetic |
SWR1 |
YDR334W |
Swi2/Snf2-related ATPase |
genetic |
5 |
3 |
4 |
Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect |
HHF1 |
YBR009C |
Histone H4 |
genetic |
5 |
2 |
4 |
Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic |
PAC2 |
YER007W |
Microtubule effector required for tubulin heterodimer formation |
genetic |
5 |
2 |
4 |
Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic |
SIC1 |
YLR079W |
Cyclin-dependent kinase inhibitor (CKI) |
genetic |
5 |
2 |
4 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
HHF2 |
YNL030W |
Histone H4 |
genetic |
5 |
4 |
3 |
Synthetic Growth Defect, Negative Genetic, Phenotypic Suppression, Synthetic Growth Defect, Phenotypic Enhancement |
MAD2 |
YJL030W |
Component of the spindle-assembly checkpoint complex |
physical |
4 |
4 |
4 |
Co-purification, Two-hybrid, Reconstituted Complex, Affinity Capture-Western |
DIA2 |
YOR080W |
Origin-binding F-box protein |
genetic |
4 |
3 |
4 |
Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Negative Genetic |
CDH1 |
YGL003C |
Activator of anaphase-promoting complex/cyclosome (APC/C) |
genetic |
4 |
3 |
4 |
Synthetic Growth Defect, Synthetic Lethality, Negative Genetic, Negative Genetic |
RAD53 |
YPL153C |
DNA damage response kinase |
genetic |
4 |
3 |
4 |
Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Suppression, Synthetic Growth Defect |
DSN1 |
YIR010W |
Essential component of the outer kinetochore MIND complex |
genetic |
4 |
2 |
4 |
Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic |
CDC20 |
YGL116W |
Activator of anaphase-promoting complex/cyclosome (APC/C) |
genetic |
4 |
2 |
4 |
Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Suppression, Phenotypic Suppression |
CDC7 |
YDL017W |
S/T kinase and catalytic subunit of DDK (Dbf4-dependent kinase) |
genetic |
4 |
2 |
4 |
Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic |
STU2 |
YLR045C |
Microtubule polymerase of the XMAP215/Dis1 family |
genetic |
4 |
2 |
4 |
Synthetic Rescue, Negative Genetic, Negative Genetic, Negative Genetic |
SWC5 |
YBR231C |
Component of the SWR1 complex |
genetic |
4 |
2 |
4 |
Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic |
SPC24 |
YMR117C |
Component of the kinetochore-associated Ndc80 complex |
genetic |
4 |
2 |
4 |
Negative Genetic, Synthetic Lethality, Negative Genetic, Negative Genetic |
GLC7 |
YER133W |
Type 1 S/T protein phosphatase (PP1) catalytic subunit |
genetic |
4 |
3 |
3 |
Synthetic Lethality, Synthetic Lethality, Synthetic Rescue, Dosage Lethality |
VPS71 |
YML041C |
Nucleosome-binding component of the SWR1 complex |
genetic |
4 |
3 |
3 |
Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect |
SHP1 |
YBL058W |
UBX domain-containing substrate adaptor for Cdc48p |
genetic |
4 |
3 |
3 |
Negative Genetic, Phenotypic Suppression, Synthetic Growth Defect, Negative Genetic |
EAF1 |
YDR359C |
Component of the NuA4 histone acetyltransferase complex |
genetic |
4 |
1 |
3 |
Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality |
MSA1 |
YOR066W |
Activator of G1-specific transcription factors MBF and SBF |
genetic |
4 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
CDC28 |
YBR160W |
Cyclin-dependent kinase (CDK) catalytic subunit |
genetic |
3 |
3 |
3 |
Phenotypic Enhancement, Phenotypic Suppression, Synthetic Rescue |
CTF13 |
YMR094W |
Subunit of the CBF3 complex |
genetic |
3 |
3 |
3 |
Synthetic Lethality, Synthetic Growth Defect, Negative Genetic |
YAF9 |
YNL107W |
Subunit of NuA4 histone H4 acetyltransferase and SWR1 complexes |
genetic |
3 |
3 |
3 |
Synthetic Lethality, Negative Genetic, Synthetic Growth Defect |
MPS1 |
YDL028C |
Dual-specificity kinase |
genetic |
3 |
3 |
3 |
Synthetic Rescue, Phenotypic Suppression, Negative Genetic |
BUB1 |
YGR188C |
Protein kinase involved in the cell cycle checkpoint into anaphase |
physical |
3 |
3 |
3 |
Reconstituted Complex, Affinity Capture-Western, Co-localization |
KIP3 |
YGL216W |
Kinesin-related antiparallel sliding motor protein |
genetic |
3 |
3 |
3 |
Synthetic Rescue, Synthetic Growth Defect, Negative Genetic |
CDC14 |
YFR028C |
Protein phosphatase required for mitotic exit |
genetic |
3 |
2 |
3 |
Phenotypic Suppression, Phenotypic Suppression, Phenotypic Enhancement |
CDC5 |
YMR001C |
Polo-like kinase required for mitotic exit |
genetic |
3 |
2 |
3 |
Phenotypic Enhancement, Phenotypic Suppression, Phenotypic Suppression |
DUO1 |
YGL061C |
Essential subunit of the Dam1 complex (aka DASH complex) |
genetic |
3 |
2 |
3 |
Synthetic Growth Defect, Negative Genetic, Negative Genetic |
PFD1 |
YJL179W |
Subunit of heterohexameric prefoldin |
genetic |
3 |
2 |
3 |
Synthetic Lethality, Negative Genetic, Synthetic Lethality |
NDC80 |
YIL144W |
Component of the kinetochore-associated Ndc80 complex |
genetic |
3 |
2 |
3 |
Synthetic Rescue, Negative Genetic, Negative Genetic |
AME1 |
YBR211C |
Essential kinetochore protein associated with microtubules and SPBs |
genetic |
3 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic |
NNF1 |
YJR112W |
Essential component of the outer kinetochore MIND complex |
genetic |
3 |
1 |
3 |
Phenotypic Suppression, Phenotypic Suppression, Phenotypic Suppression |
SCC2 |
YDR180W |
Subunit of cohesin loading factor (Scc2p-Scc4p) |
genetic |
3 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic |
SMC1 |
YFL008W |
Subunit of the multiprotein cohesin complex |
genetic |
3 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic |
ELG1 |
YOR144C |
Subunit of an alternative replication factor C complex |
genetic |
3 |
3 |
2 |
Synthetic Rescue, Negative Genetic, Positive Genetic |
HHT1 |
YBR010W |
Histone H3 |
genetic |
3 |
2 |
2 |
Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Suppression |
YNG2 |
YHR090C |
Subunit of NuA4, an essential histone acetyltransferase complex |
genetic |
3 |
2 |
2 |
Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic |
DAD1 |
YDR016C |
Essential subunit of the Dam1 complex (aka DASH complex) |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
SAC3 |
YDR159W |
mRNA export factor |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
OKP1 |
YGR179C |
Outer kinetochore protein required for accurate chromosome segregation |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
CDC16 |
YKL022C |
Subunit of the anaphase-promoting complex/cyclosome (APC/C) |
genetic |
2 |
2 |
2 |
Synthetic Rescue, Phenotypic Enhancement |
FKS1 |
YLR342W |
Catalytic subunit of 1,3-beta-D-glucan synthase |
genetic |
2 |
2 |
2 |
Phenotypic Enhancement, Positive Genetic |
HSP82 |
YPL240C |
Hsp90 chaperone |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Synthetic Growth Defect |
MAD3 |
YJL013C |
Subunit of spindle-assembly checkpoint complex |
genetic |
2 |
2 |
2 |
Phenotypic Suppression, Synthetic Rescue |
POL1 |
YNL102W |
Catalytic subunit of the DNA polymerase I alpha-primase complex |
genetic |
2 |
2 |
2 |
Phenotypic Suppression, Synthetic Rescue |
SGO1 |
YOR073W |
Component of the spindle checkpoint |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Negative Genetic |
SWC3 |
YAL011W |
Protein of unknown function |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Synthetic Growth Defect |
VPS64 |
YDR200C |
Protein required for cytoplasm to vacuole targeting of proteins |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Negative Genetic |
MDM20 |
YOL076W |
Non-catalytic subunit of the NatB N-terminal acetyltransferase |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Negative Genetic |
SWM1 |
YDR260C |
Subunit of the anaphase-promoting complex (APC) |
genetic |
2 |
2 |
2 |
Synthetic Rescue, Phenotypic Suppression |
SFI1 |
YLL003W |
Centrin (Cdc31p)-binding protein required for SPB duplication |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Negative Genetic |
SWE1 |
YJL187C |
Protein kinase that regulates the G2/M transition |
genetic |
2 |
2 |
2 |
Dosage Rescue, Phenotypic Enhancement |
SMT3 |
YDR510W |
Ubiquitin-like protein of the SUMO family |
genetic |
2 |
2 |
2 |
Phenotypic Suppression, Positive Genetic |
RAD1 |
YPL022W |
Single-stranded DNA endonuclease (with Rad10p) |
genetic |
2 |
2 |
2 |
Phenotypic Suppression, Synthetic Lethality |
RAS2 |
YNL098C |
GTP-binding protein |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Synthetic Rescue |
SPC105 |
YGL093W |
Subunit of a kinetochore-microtubule binding complex |
genetic |
2 |
2 |
2 |
Synthetic Rescue, Negative Genetic |
SPC110 |
YDR356W |
Inner plaque spindle pole body (SPB) component |
genetic |
2 |
2 |
2 |
Phenotypic Enhancement, Synthetic Growth Defect |
CSM3 |
YMR048W |
Replication fork associated factor |
genetic |
2 |
2 |
2 |
Phenotypic Suppression, Negative Genetic |
ERV14 |
YGL054C |
COPII-coated vesicle protein |
genetic |
2 |
2 |
2 |
Phenotypic Suppression, Positive Genetic |
DHH1 |
YDL160C |
Cytoplasmic DEAD-box helicase and mRNA decapping activator |
physical |
2 |
1 |
2 |
Affinity Capture-RNA, Affinity Capture-RNA |
CMD1 |
YBR109C |
Calmodulin |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
MAD3 |
YJL013C |
Subunit of spindle-assembly checkpoint complex |
physical |
2 |
1 |
2 |
Affinity Capture-Western, Affinity Capture-Western |
UME6 |
YDR207C |
Rpd3L histone deacetylase complex subunit |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
PSF1 |
YDR013W |
Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
PRP22 |
YER013W |
DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
NSL1 |
YPL233W |
Essential component of the MIND kinetochore complex |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
MEC1 |
YBR136W |
Genome integrity checkpoint protein and PI kinase superfamily member |
genetic |
2 |
1 |
2 |
Phenotypic Suppression, Phenotypic Suppression |
PDS5 |
YMR076C |
Cohesion maintenance factor |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
SPC98 |
YNL126W |
Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
NUF2 |
YOL069W |
Component of the kinetochore-associated Ndc80 complex |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
SGT1 |
YOR057W |
Cochaperone protein |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
CBF1 |
YJR060W |
Basic helix-loop-helix (bHLH) protein |
genetic |
2 |
1 |
2 |
Synthetic Lethality, Synthetic Lethality |
DBF4 |
YDR052C |
Regulatory subunit of Cdc7p-Dbf4p kinase complex |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
CHD1 |
YER164W |
Chromatin remodeler that regulates various aspects of transcription |
genetic |
2 |
2 |
1 |
Positive Genetic, Negative Genetic |
HDA3 |
YPR179C |
Subunit of HDA1 histone deacetylase complex |
genetic |
2 |
2 |
1 |
Positive Genetic, Negative Genetic |
SPO13 |
YHR014W |
Meiotic regulator |
genetic |
2 |
2 |
1 |
Synthetic Rescue, Phenotypic Enhancement |
TSA1 |
YML028W |
Thioredoxin peroxidase |
genetic |
2 |
2 |
1 |
Negative Genetic, Positive Genetic |
SNT1 |
YCR033W |
Set3C histone deacetylase scaffold |
genetic |
2 |
2 |
1 |
Positive Genetic, Negative Genetic |
RPN6 |
YDL097C |
Essential, non-ATPase regulatory subunit of the 26S proteasome lid |
genetic |
2 |
2 |
1 |
Positive Genetic, Negative Genetic |
ESA1 |
YOR244W |
Catalytic subunit of the histone acetyltransferase complex (NuA4) |
genetic |
2 |
1 |
1 |
Synthetic Growth Defect, Synthetic Growth Defect |
BET2 |
YPR176C |
Beta subunit of Type II geranylgeranyltransferase |
physical |
2 |
1 |
1 |
Biochemical Activity, Biochemical Activity |
INO2 |
YDR123C |
Transcription factor |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
MRS6 |
YOR370C |
Rab escort protein |
physical |
2 |
1 |
1 |
Biochemical Activity, Biochemical Activity |
MPS3 |
YJL019W |
Nuclear envelope protein |
genetic |
2 |
1 |
1 |
Synthetic Growth Defect, Synthetic Growth Defect |
BIK1 |
YCL029C |
Microtubule-associated protein |
genetic |
2 |
1 |
1 |
Synthetic Growth Defect, Synthetic Growth Defect |
FKH1 |
YIL131C |
Forkhead family transcription factor |
regulation |
1 |
1 |
1 |
ChEC-Seq experiments |
IXR1 |
YKL032C |
Transcriptional repressor that regulates hypoxic genes during normoxia |
regulation |
1 |
1 |
1 |
DNA to cDNA expression microarray evidence |
RFX1 |
YLR176C |
Major transcriptional repressor of DNA-damage-regulated genes |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
RGR1 |
YLR071C |
Subunit of the RNA polymerase II mediator complex |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
CWC25 |
YNL245C |
Splicing factor required for the first step of pre-mRNA splicing |
genetic |
1 |
1 |
1 |
Negative Genetic |
CKA1 |
YIL035C |
Alpha catalytic subunit of casein kinase 2 (CK2) |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
CKA2 |
YOR061W |
Alpha' catalytic subunit of casein kinase 2 (CK2) |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
CKB1 |
YGL019W |
Beta regulatory subunit of casein kinase 2 (CK2) |
genetic |
1 |
1 |
1 |
Negative Genetic |
BMH1 |
YER177W |
14-3-3 protein, major isoform |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
LSM1 |
YJL124C |
Lsm (Like Sm) protein |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
LSM6 |
YDR378C |
Lsm (Like Sm) protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
CDC48 |
YDL126C |
AAA ATPase with protein-unfoldase activity |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
LRP1 |
YHR081W |
Nuclear exosome-associated nucleic acid binding protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
HPR1 |
YDR138W |
Subunit of THO/TREX complexes |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
ACT1 |
YFL039C |
Actin, structural protein in cytoskeleton |
genetic |
1 |
1 |
1 |
Negative Genetic |
KAP95 |
YLR347C |
Karyopherin beta |
genetic |
1 |
1 |
1 |
Negative Genetic |
APC1 |
YNL172W |
Largest subunit of the Anaphase-Promoting Complex/Cyclosome |
genetic |
1 |
1 |
1 |
Negative Genetic |
APL1 |
YJR005W |
Beta-adaptin |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
ARC18 |
YLR370C |
Subunit of the ARP2/3 complex |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
BEM1 |
YBR200W |
Protein containing SH3-domains |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
BET3 |
YKR068C |
Core component of transport protein particle (TRAPP) complexes I-III |
genetic |
1 |
1 |
1 |
Positive Genetic |
BET2 |
YPR176C |
Beta subunit of Type II geranylgeranyltransferase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
BEM2 |
YER155C |
Rho GTPase activating protein (RhoGAP) |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
BUD14 |
YAR014C |
Protein involved in bud-site selection |
genetic |
1 |
1 |
1 |
Negative Genetic |
CDC45 |
YLR103C |
DNA replication initiation factor |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
BNI1 |
YNL271C |
Formin |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
CDC55 |
YGL190C |
Regulatory subunit B of protein phosphatase 2A (PP2A) |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
CKS1 |
YBR135W |
Cyclin-dependent protein kinase regulatory subunit and adaptor |
genetic |
1 |
1 |
1 |
Negative Genetic |
CDC16 |
YKL022C |
Subunit of the anaphase-promoting complex/cyclosome (APC/C) |
physical |
1 |
1 |
1 |
Protein-peptide |
CDC23 |
YHR166C |
Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) |
genetic |
1 |
1 |
1 |
Positive Genetic |
ELP2 |
YGR200C |
Subunit of Elongator complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
ENO1 |
YGR254W |
Enolase I, a phosphopyruvate hydratase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
GCN3 |
YKR026C |
Alpha subunit of translation initiation factor eIF2B |
genetic |
1 |
1 |
1 |
Positive Genetic |
ESP1 |
YGR098C |
Separase/separin, a caspase-like cysteine protease |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
DYN1 |
YKR054C |
Cytoplasmic heavy chain dynein |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
LSM7 |
YNL147W |
Lsm (Like Sm) protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
ENO2 |
YHR174W |
Enolase II, a phosphopyruvate hydratase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
CSE2 |
YNR010W |
Subunit of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
COG3 |
YER157W |
Essential component of the conserved oligomeric Golgi complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
HSC82 |
YMR186W |
Cytoplasmic chaperone of the Hsp90 family |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
HRR25 |
YPL204W |
Conserved casein kinase, monopolin subunit |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
AHA1 |
YDR214W |
Co-chaperone that binds Hsp82p and activates its ATPase activity |
physical |
1 |
1 |
1 |
Two-hybrid |
HSP42 |
YDR171W |
Small heat shock protein (sHSP) with chaperone activity |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
DOA4 |
YDR069C |
Ubiquitin hydrolase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
CSE1 |
YGL238W |
Nuclear envelope protein that acts as a recycling factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
HOS2 |
YGL194C |
Histone deacetylase and subunit of Set3 and Rpd3L complexes |
genetic |
1 |
1 |
1 |
Positive Genetic |
BCY1 |
YIL033C |
Regulatory subunit of the cyclic AMP-dependent protein kinase (PKA) |
genetic |
1 |
1 |
1 |
Dosage Lethality |
BNA3 |
YJL060W |
Kynurenine aminotransferase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
LPL1 |
YOR059C |
Phospholipase |
genetic |
1 |
1 |
1 |
Positive Genetic |
IRA2 |
YOL081W |
GTPase-activating protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
CAF20 |
YOR276W |
Phosphoprotein of the mRNA cap-binding complex |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
CAF20 |
YOR276W |
Phosphoprotein of the mRNA cap-binding complex |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
CPR6 |
YLR216C |
Peptidyl-prolyl cis-trans isomerase (cyclophilin) |
genetic |
1 |
1 |
1 |
Negative Genetic |
GET2 |
YER083C |
Subunit of the GET complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
CHK1 |
YBR274W |
Serine/threonine kinase and DNA damage checkpoint effector |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
BFA1 |
YJR053W |
Subunit of a two-component GTPase-activating protein, Bfa1p-Bub2p |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
CLN1 |
YMR199W |
G1 cyclin involved in regulation of the cell cycle |
genetic |
1 |
1 |
1 |
Negative Genetic |
FUM1 |
YPL262W |
Fumarase |
genetic |
1 |
1 |
1 |
Negative Genetic |
LAF1 |
YMR102C |
Sterol-binding beta-propeller protein |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
ELM1 |
YKL048C |
Serine/threonine protein kinase |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
GPN3 |
YLR243W |
Putative GTPase with a role in biogenesis of RNA pol II and polIII |
genetic |
1 |
1 |
1 |
Negative Genetic |
CDC15 |
YAR019C |
Hippo-like kinase of the Mitotic Exit Network |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
KEL2 |
YGR238C |
Protein that negatively regulates mitotic exit |
physical |
1 |
1 |
1 |
Two-hybrid |
HHT1 |
YBR010W |
Histone H3 |
physical |
1 |
1 |
1 |
Reconstituted Complex |
DPB11 |
YJL090C |
DNA replication initiation protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
EAP1 |
YKL204W |
eIF4E-associated protein, competes with eIF4G for binding to eIF4E |
physical |
1 |
1 |
1 |
Two-hybrid |
BUB3 |
YOR026W |
Kinetochore checkpoint WD40 repeat protein |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
BUB3 |
YOR026W |
Kinetochore checkpoint WD40 repeat protein |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
IST3 |
YIR005W |
Component of the U2 snRNP |
genetic |
1 |
1 |
1 |
Negative Genetic |
ISA1 |
YLL027W |
Protein required for maturation of mitochondrial [4Fe-4S] proteins |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
DHR2 |
YKL078W |
Predominantly nucleolar DEAH-box ATP-dependent RNA helicase |
genetic |
1 |
1 |
1 |
Positive Genetic |
APL4 |
YPR029C |
Gamma-adaptin |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
ESS1 |
YJR017C |
Peptidylprolyl-cis/trans-isomerase (PPIase) |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
ARP1 |
YHR129C |
Actin-related protein of the dynactin complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
CIN4 |
YMR138W |
GTP-binding protein involved in beta-tubulin (Tub2p) folding |
genetic |
1 |
1 |
1 |
Negative Genetic |
EBS1 |
YDR206W |
Protein involved in translation inhibition and nonsense-mediated decay |
physical |
1 |
1 |
1 |
Two-hybrid |
BIT61 |
YJL058C |
Subunit of TORC2 membrane-associated complex |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
ATG39 |
YLR312C |
Transmembrane receptor with a role in nucleophagy |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
MSB2 |
YGR014W |
Mucin family member involved in various signaling pathways |
physical |
1 |
1 |
1 |
Two-hybrid |
NUP157 |
YER105C |
Subunit of the inner ring of the nuclear pore complex (NPC) |
physical |
1 |
1 |
1 |
Two-hybrid |
SAP4 |
YGL229C |
Protein required for function of the Sit4p protein phosphatase |
physical |
1 |
1 |
1 |
Two-hybrid |
SIN4 |
YNL236W |
Subunit of the RNA polymerase II mediator complex |
physical |
1 |
1 |
1 |
Two-hybrid |
SIN4 |
YNL236W |
Subunit of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
MGS1 |
YNL218W |
Protein with DNA-dependent ATPase and ssDNA annealing activities |
physical |
1 |
1 |
1 |
Two-hybrid |
YPT1 |
YFL038C |
Rab family GTPase |
physical |
1 |
1 |
1 |
Biochemical Activity |
PDC1 |
YLR044C |
Major of three pyruvate decarboxylase isozymes |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
PGK1 |
YCR012W |
3-phosphoglycerate kinase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RRB1 |
YMR131C |
Specific assembly chaperone for ribosomal protein Rpl3p |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
TRX2 |
YGR209C |
Cytoplasmic thioredoxin isoenzyme |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
URA7 |
YBL039C |
Major CTP synthase isozyme (see also URA8) |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
YOR283W |
YOR283W |
Phosphatase with a broad substrate specificity |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
UFD2 |
YDL190C |
Ubiquitin (Ub) chain assembly factor (E4) |
physical |
1 |
1 |
1 |
Two-hybrid |
YGR273C |
YGR273C |
Putative protein of unknown function |
physical |
1 |
1 |
1 |
Two-hybrid |
YJL206C |
YJL206C |
Putative protein of unknown function |
physical |
1 |
1 |
1 |
Two-hybrid |
SCM3 |
YDL139C |
Nonhistone component of centromeric chromatin |
physical |
1 |
1 |
1 |
Two-hybrid |
SCM3 |
YDL139C |
Nonhistone component of centromeric chromatin |
genetic |
1 |
1 |
1 |
Negative Genetic |
TYC1 |
YBR296C-A |
Inhibitor of the Anaphase-Promoting Complex/Cyclosome (APC/C) |
physical |
1 |
1 |
1 |
PCA |
TYC1 |
YBR296C-A |
Inhibitor of the Anaphase-Promoting Complex/Cyclosome (APC/C) |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
PDR12 |
YPL058C |
Plasma membrane ATP-binding cassette (ABC) transporter |
physical |
1 |
1 |
1 |
PCA |
SEC18 |
YBR080C |
AAA ATPase and SNARE disassembly chaperone |
physical |
1 |
1 |
1 |
Two-hybrid |
POG1 |
YIL122W |
DNA-binding transcriptional activator |
physical |
1 |
1 |
1 |
Two-hybrid |
MSN1 |
YOL116W |
Transcriptional activator |
physical |
1 |
1 |
1 |
Two-hybrid |
NAB2 |
YGL122C |
Nuclear polyadenylated RNA-binding protein |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
SLF1 |
YDR515W |
RNA binding protein that associates with polysomes |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
SRO9 |
YCL037C |
Cytoplasmic RNA-binding protein |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
PUF3 |
YLL013C |
Protein of the mitochondrial outer surface |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
RPS6B |
YBR181C |
Protein component of the small (40S) ribosomal subunit |
physical |
1 |
1 |
1 |
Co-fractionation |
MTW1 |
YAL034W-A |
Essential component of the MIND kinetochore complex |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
MPS2 |
YGL075C |
Essential membrane protein localized at nuclear envelope and SPBs |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
SKP1 |
YDR328C |
Evolutionarily conserved kinetochore protein |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
MCM3 |
YEL032W |
Protein involved in DNA replication |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
NTF2 |
YER009W |
Nuclear envelope protein |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
MCD1 |
YDL003W |
Essential alpha-kleisin subunit of the cohesin complex |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
SPC34 |
YKR037C |
Essential subunit of the Dam1 complex (aka DASH complex) |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
MSR1 |
YHR091C |
Mitochondrial arginyl-tRNA synthetase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
NAT3 |
YPR131C |
Catalytic subunit of the NatB N-terminal acetyltransferase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
PLC1 |
YPL268W |
Phospholipase C |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
RAD10 |
YML095C |
Single-stranded DNA endonuclease (with Rad1p) |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
RAD23 |
YEL037C |
Protein with ubiquitin-like N terminus |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
RSM24 |
YDR175C |
Mitochondrial ribosomal protein of the small subunit |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
RSN1 |
YMR266W |
Membrane protein of unknown function |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
SAG1 |
YJR004C |
Alpha-agglutinin of alpha-cells |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
SHM2 |
YLR058C |
Cytosolic serine hydroxymethyltransferase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
SLI15 |
YBR156C |
Subunit of the conserved chromosomal passenger complex (CPC) |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
TDH2 |
YJR009C |
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), isozyme 2 |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
WHI5 |
YOR083W |
Repressor of G1 transcription |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
YLR287C |
YLR287C |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
ORC1 |
YML065W |
Largest subunit of the origin recognition complex |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
RIM1 |
YCR028C-A |
ssDNA-binding protein essential for mitochondrial genome maintenance |
genetic |
1 |
1 |
1 |
Negative Genetic |
THP1 |
YOL072W |
Nuclear pore-associated protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
SUS1 |
YBR111W-A |
Global transcriptional regulator, component of SAGA, TREX-2 complexes |
genetic |
1 |
1 |
1 |
Negative Genetic |
VPS70 |
YJR126C |
Protein of unknown function involved in vacuolar protein sorting |
genetic |
1 |
1 |
1 |
Negative Genetic |
POL31 |
YJR006W |
Subunit of DNA polymerase delta (polymerase III) |
genetic |
1 |
1 |
1 |
Negative Genetic |
REC107 |
YJR021C |
Protein involved in early stages of meiotic recombination |
genetic |
1 |
1 |
1 |
Negative Genetic |
TAF13 |
YML098W |
TFIID subunit (19 kDa) |
genetic |
1 |
1 |
1 |
Positive Genetic |
NUP133 |
YKR082W |
Subunit of Nup84p subcomplex of nuclear pore complex (NPC) |
genetic |
1 |
1 |
1 |
Positive Genetic |
RAD24 |
YER173W |
Checkpoint protein |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
SPO11 |
YHL022C |
Meiosis-specific protein required for meiotic recombination |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
YKU70 |
YMR284W |
Subunit of the telomeric Ku complex (Yku70p-Yku80p) |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
ORC2 |
YBR060C |
Subunit of the origin recognition complex (ORC) |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
RFC5 |
YBR087W |
Subunit of heteropentameric Replication factor C (RF-C) |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
MRE11 |
YMR224C |
Nuclease subunit of the MRX complex with Rad50p and Xrs2p |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
RFA1 |
YAR007C |
Subunit of heterotrimeric Replication Protein A (RPA) |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
PIF1 |
YML061C |
DNA helicase, potent G-quadruplex DNA binder/unwinder |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
RSC2 |
YLR357W |
Component of the RSC chromatin remodeling complex |
genetic |
1 |
1 |
1 |
Dosage Lethality |
NET1 |
YJL076W |
Core subunit of the RENT complex |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
RAD26 |
YJR035W |
Protein involved in transcription-coupled nucleotide excision repair |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
PDS1 |
YDR113C |
Securin |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
SNF2 |
YOR290C |
Catalytic subunit of the SWI/SNF chromatin remodeling complex |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
ULP2 |
YIL031W |
Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
RAD9 |
YDR217C |
DNA damage-dependent checkpoint protein |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
NPL3 |
YDR432W |
RNA-binding protein |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
PDE2 |
YOR360C |
High-affinity cyclic AMP phosphodiesterase |
genetic |
1 |
1 |
1 |
Dosage Lethality |
TPP1 |
YMR156C |
DNA 3'-phosphatase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
PAT1 |
YCR077C |
Deadenylation-dependent mRNA-decapping factor |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
RTT107 |
YHR154W |
BRCA1 C-terminal domain protein needed for recovery from DNA damage |
genetic |
1 |
1 |
1 |
Negative Genetic |
VMA3 |
YEL027W |
Proteolipid subunit c of the V0 domain of vacuolar H(+)-ATPase |
genetic |
1 |
1 |
1 |
Positive Genetic |
NDL1 |
YLR254C |
Homolog of nuclear distribution factor NudE |
genetic |
1 |
1 |
1 |
Positive Genetic |
RSO55 |
YLR281C |
Mitochondrial protein of unknown function |
genetic |
1 |
1 |
1 |
Positive Genetic |
RIM21 |
YNL294C |
pH sensor molecule, component of the RIM101 pathway |
genetic |
1 |
1 |
1 |
Positive Genetic |
VMA13 |
YPR036W |
Subunit H of the V1 peripheral membrane domain of V-ATPase |
genetic |
1 |
1 |
1 |
Positive Genetic |
SPC19 |
YDR201W |
Essential subunit of the Dam1 complex (aka DASH complex) |
genetic |
1 |
1 |
1 |
Negative Genetic |
SRM1 |
YGL097W |
Nucleotide exchange factor for Gsp1p |
genetic |
1 |
1 |
1 |
Negative Genetic |
SWC4 |
YGR002C |
Component of the Swr1p complex that incorporates Htz1p into chromatin |
genetic |
1 |
1 |
1 |
Negative Genetic |
RPB10 |
YOR210W |
RNA polymerase subunit ABC10-beta |
genetic |
1 |
1 |
1 |
Negative Genetic |
SPC29 |
YPL124W |
Inner plaque spindle pole body (SPB) component |
genetic |
1 |
1 |
1 |
Negative Genetic |
MIS1 |
YBR084W |
Mitochondrial C1-tetrahydrofolate synthase |
genetic |
1 |
1 |
1 |
Negative Genetic |
MRPL27 |
YBR282W |
Mitochondrial ribosomal protein of the large subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
YCL001W-B |
YCL001W-B |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
YCP4 |
YCR004C |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
TRP4 |
YDR354W |
Anthranilate phosphoribosyl transferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
SOM1 |
YEL059C-A |
Subunit of the mitochondrial inner membrane peptidase (IMP) |
genetic |
1 |
1 |
1 |
Negative Genetic |
TIM21 |
YGR033C |
Nonessential component of the TIM23 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
PSE1 |
YMR308C |
Karyopherin/importin that interacts with the nuclear pore complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
SET1 |
YHR119W |
Histone methyltransferase, subunit of the COMPASS (Set1C) complex |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
RTT101 |
YJL047C |
Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
ZWF1 |
YNL241C |
Glucose-6-phosphate dehydrogenase (G6PD) |
genetic |
1 |
1 |
1 |
Negative Genetic |
MCM10 |
YIL150C |
Essential chromatin-associated protein |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
SLX5 |
YDL013W |
Subunit of the Slx5-Slx8 SUMO-targeted Ub ligase (STUbL) complex |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
MIH1 |
YMR036C |
Protein tyrosine phosphatase |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
SHO1 |
YER118C |
Transmembrane osmosensor for filamentous growth and HOG pathways |
genetic |
1 |
1 |
1 |
Negative Genetic |
RIO1 |
YOR119C |
Serine kinase involved in cell cycle regulation and rDNA integrity |
genetic |
1 |
1 |
1 |
Positive Genetic |
NUP188 |
YML103C |
Subunit of the inner ring of the nuclear pore complex (NPC) |
genetic |
1 |
1 |
1 |
Positive Genetic |
VPS17 |
YOR132W |
Subunit of the membrane-associated retromer complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
PKC1 |
YBL105C |
Protein serine/threonine kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
THR4 |
YCR053W |
Threonine synthase |
genetic |
1 |
1 |
1 |
Negative Genetic |
POL3 |
YDL102W |
Catalytic subunit of DNA polymerase delta |
genetic |
1 |
1 |
1 |
Positive Genetic |
TRS85 |
YDR108W |
Component of transport protein particle (TRAPP) complex III |
genetic |
1 |
1 |
1 |
Positive Genetic |
SUM1 |
YDR310C |
Transcriptional repressor that regulates middle-sporulation genes |
genetic |
1 |
1 |
1 |
Positive Genetic |
UTP6 |
YDR449C |
Nucleolar protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
SWI4 |
YER111C |
DNA binding component of the SBF complex (Swi4p-Swi6p) |
genetic |
1 |
1 |
1 |
Positive Genetic |
PET122 |
YER153C |
Mitochondrial translational activator specific for the COX3 mRNA |
genetic |
1 |
1 |
1 |
Negative Genetic |
SLD3 |
YGL113W |
Protein involved in the initiation of DNA replication |
genetic |
1 |
1 |
1 |
Negative Genetic |
TIP20 |
YGL145W |
Peripheral membrane protein required for COPI vesicle fusion to the ER |
genetic |
1 |
1 |
1 |
Positive Genetic |
PEF1 |
YGR058W |
Penta-EF-hand protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
RPL14A |
YKL006W |
Ribosomal 60S subunit protein L14A |
genetic |
1 |
1 |
1 |
Positive Genetic |
RAD27 |
YKL113C |
5' to 3' exonuclease, 5' flap endonuclease |
genetic |
1 |
1 |
1 |
Positive Genetic |
PPG1 |
YNR032W |
Serine protein phosphatase involved in formation of FAR complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
RTS1 |
YOR014W |
B-type regulatory subunit of protein phosphatase 2A (PP2A) |
genetic |
1 |
1 |
1 |
Negative Genetic |
RRD2 |
YPL152W |
Peptidyl-prolyl cis/trans-isomerase |
genetic |
1 |
1 |
1 |
Positive Genetic |
MED1 |
YPR070W |
Subunit of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
SEC23 |
YPR181C |
GTPase-activating protein, stimulates the GTPase activity of Sar1p |
genetic |
1 |
1 |
1 |
Positive Genetic |
MTC4 |
YBR255W |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Positive Genetic |
TAF12 |
YDR145W |
Subunit (61/68 kDa) of TFIID and SAGA complexes |
genetic |
1 |
1 |
1 |
Negative Genetic |
RPA14 |
YDR156W |
RNA polymerase I subunit A14 |
genetic |
1 |
1 |
1 |
Positive Genetic |
SPT3 |
YDR392W |
Subunit of the SAGA and SAGA-like transcriptional regulatory complexes |
genetic |
1 |
1 |
1 |
Negative Genetic |
SCC4 |
YER147C |
Subunit of cohesin loading factor (Scc2p-Scc4p) |
genetic |
1 |
1 |
1 |
Negative Genetic |
NUT1 |
YGL151W |
Component of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
PRI1 |
YIR008C |
Subunit of DNA primase |
genetic |
1 |
1 |
1 |
Positive Genetic |
ZRC1 |
YMR243C |
Vacuolar membrane zinc transporter |
genetic |
1 |
1 |
1 |
Negative Genetic |
MSH2 |
YOL090W |
Protein that binds to DNA mismatches |
genetic |
1 |
1 |
1 |
Negative Genetic |
VAC17 |
YCL063W |
Phosphoprotein involved in vacuole inheritance |
genetic |
1 |
1 |
1 |
Negative Genetic |
SLP1 |
YOR154W |
Glycosylated integral ER membrane protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
UBC4 |
YBR082C |
Ubiquitin-conjugating enzyme (E2) |
genetic |
1 |
1 |
1 |
Negative Genetic |
PAN2 |
YGL094C |
Catalytic subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
NQM1 |
YGR043C |
Transaldolase of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
RPN1 |
YHR027C |
Non-ATPase base subunit of the 19S RP of the 26S proteasome |
genetic |
1 |
1 |
1 |
Negative Genetic |
NMD2 |
YHR077C |
Protein involved in the nonsense-mediated mRNA decay (NMD) pathway |
genetic |
1 |
1 |
1 |
Negative Genetic |
RPN10 |
YHR200W |
Proteasome polyubiquitin receptor |
genetic |
1 |
1 |
1 |
Negative Genetic |
SIS2 |
YKR072C |
Negative regulatory subunit of protein phosphatase 1 (Ppz1p) |
genetic |
1 |
1 |
1 |
Negative Genetic |
TAG1 |
YLR173W |
Vacuolar membrane protein involved in termination of autophagy |
genetic |
1 |
1 |
1 |
Negative Genetic |
NKP2 |
YLR315W |
Central kinetochore protein and subunit of the Ctf19 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
VRP1 |
YLR337C |
Verprolin, proline-rich actin-associated protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
NAM7 |
YMR080C |
ATP-dependent RNA helicase of the SFI superfamily |
genetic |
1 |
1 |
1 |
Negative Genetic |
UBP8 |
YMR223W |
Ubiquitin-specific protease component of the SAGA acetylation complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
YDJ1 |
YNL064C |
Type I HSP40 co-chaperone |
genetic |
1 |
1 |
1 |
Negative Genetic |
PHO80 |
YOL001W |
Cyclin |
genetic |
1 |
1 |
1 |
Negative Genetic |
RPN7 |
YPR108W |
Essential non-ATPase regulatory subunit of the 26S proteasome |
genetic |
1 |
1 |
1 |
Negative Genetic |
SPC42 |
YKL042W |
Central plaque component of spindle pole body (SPB) |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
RLF2 |
YPR018W |
Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1) |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
ORC5 |
YNL261W |
Subunit of the origin recognition complex (ORC) |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
CAK1 |
YFL029C |
Cyclin-dependent kinase-activating kinase |
genetic |
1 |
1 |
1 |
Positive Genetic |
COQ5 |
YML110C |
2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
ASK1 |
YKL052C |
Essential subunit of the Dam1 complex (aka DASH complex) |
genetic |
1 |
1 |
1 |
Negative Genetic |
IBD2 |
YNL164C |
Component of the BUB2-dependent spindle checkpoint pathway |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
AIM4 |
YBR194W |
Protein proposed to be associated with the nuclear pore complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
APC9 |
YLR102C |
Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) |
genetic |
1 |
1 |
1 |
Positive Genetic |
CEP3 |
YMR168C |
Essential kinetochore protein |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
DOC1 |
YGL240W |
Processivity factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
AMD1 |
YML035C |
AMP deaminase |
genetic |
1 |
1 |
1 |
Negative Genetic |
ARP6 |
YLR085C |
Actin-related protein that binds nucleosomes |
genetic |
1 |
1 |
1 |
Negative Genetic |
HPC2 |
YBR215W |
Subunit of the HIR complex |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
APN1 |
YKL114C |
Major apurinic/apyrimidinic endonuclease |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
AMA1 |
YGR225W |
Activator of meiotic anaphase promoting complex (APC/C) |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
BUB1 |
YGR188C |
Protein kinase involved in the cell cycle checkpoint into anaphase |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
CLB5 |
YPR120C |
B-type cyclin involved in DNA replication during S phase |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
CTK2 |
YJL006C |
Beta subunit of C-terminal domain kinase I (CTDK-I) |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
ECO1 |
YFR027W |
Acetyltransferase required for sister chromatid cohesion |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
KAR9 |
YPL269W |
Spindle positioning factor |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
MAD1 |
YGL086W |
Coiled-coil protein involved in spindle-assembly checkpoint |
genetic |
1 |
1 |
1 |
Positive Genetic |
CCZ1 |
YBR131W |
Subunit of a heterodimeric guanine nucleotide exchange factor (GEF) |
genetic |
1 |
1 |
1 |
Positive Genetic |
HSF1 |
YGL073W |
Trimeric heat shock transcription factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
GAD1 |
YMR250W |
Glutamate decarboxylase |
genetic |
1 |
1 |
1 |
Negative Genetic |
CLA4 |
YNL298W |
Cdc42p-activated signal transducing kinase |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
HHT2 |
YNL031C |
Histone H3 |
physical |
1 |
1 |
1 |
Reconstituted Complex |
CLB3 |
YDL155W |
B-type cyclin involved in cell cycle progression |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
KIP1 |
YBL063W |
Kinesin-related motor protein |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
HBS1 |
YKR084C |
GTPase with similarity to translation release factors |
genetic |
1 |
1 |
1 |
Negative Genetic |
KIP2 |
YPL155C |
Kinesin-related motor protein involved in mitotic spindle positioning |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
ATP18 |
YML081C-A |
Subunit of the mitochondrial F1F0 ATP synthase |
genetic |
1 |
1 |
1 |
Negative Genetic |
BTS1 |
YPL069C |
Geranylgeranyl diphosphate synthase (GGPPS) |
genetic |
1 |
1 |
1 |
Positive Genetic |
ERG2 |
YMR202W |
C-8 sterol isomerase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
KEX1 |
YGL203C |
Cell death protease essential for hypochlorite-induced apoptosis |
genetic |
1 |
1 |
1 |
Positive Genetic |
ASE1 |
YOR058C |
Mitotic spindle midzone-localized microtubule bundling protein |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
KCS1 |
YDR017C |
Inositol hexakisphosphate and inositol heptakisphosphate kinase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
IRC3 |
YDR332W |
Double-stranded DNA-dependent helicase of the DExH/D-box family |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
KAE1 |
YKR038C |
Highly conserved ATPase of HSP70/DnaK family |
genetic |
1 |
1 |
1 |
Negative Genetic |
LIP5 |
YOR196C |
Protein involved in biosynthesis of the coenzyme lipoic acid |
genetic |
1 |
1 |
1 |
Positive Genetic |
HEM12 |
YDR047W |
Uroporphyrinogen decarboxylase |
genetic |
1 |
1 |
1 |
Negative Genetic |
CLB4 |
YLR210W |
B-type cyclin involved in cell cycle progression |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
GCS1 |
YDL226C |
ADP-ribosylation factor GTPase activating protein (ARF GAP) |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
EOS1 |
YNL080C |
Protein involved in N-glycosylation |
genetic |
1 |
1 |
1 |
Negative Genetic |
COX10 |
YPL172C |
Heme A:farnesyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
APE4 |
YHR113W |
Cytoplasmic aspartyl aminopeptidase with possible vacuole function |
physical |
1 |
1 |
1 |
Two-hybrid |
ITR1 |
YDR497C |
Myo-inositol transporter |
genetic |
1 |
1 |
1 |
Positive Genetic |
CRD1 |
YDL142C |
Cardiolipin synthase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
LST4 |
YKL176C |
Subunit of the Lst4p-Lst7p GTPase activating protein complex for Gtr2p |
genetic |
1 |
1 |
1 |
Negative Genetic |
APQ12 |
YIL040W |
Nuclear envelope/ER integral membrane protein |
genetic |
1 |
1 |
1 |
Synthetic Lethality |