Standard name Systematic name Name description Description
MEC1 YBR136W Genome integrity checkpoint protein and PI kinase superfamily member Genome integrity checkpoint protein and PI kinase superfamily member; Mec1p and Dun1p function in same pathway to regulate dNTP pools and telomere length; signal transducer required for cell cycle arrest and transcriptional responses to damaged or unreplicated DNA; facilitates replication fork progression and regulates P-body formation under replication stress; promotes interhomolog recombination by phosphorylating Hop1p; associates with shortened, dysfunctional telomeres
Visualize the interactome of MEC1
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
no data no data no data

GFP localization & abundance

GFP localization GFP abundance
no data no data

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
MEC1 5 1 0 0 2

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
TEL1 YBL088C Protein kinase primarily involved in telomere length regulation genetic 55 6 47 Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Suppression, Synthetic Lethality, Synthetic Rescue, Phenotypic Suppression, Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Suppression, Phenotypic Suppression, Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Rescue, Synthetic Growth Defect, Synthetic Rescue
SML1 YML058W Ribonucleotide reductase inhibitor genetic 26 4 26 Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Rescue, Synthetic Rescue, Phenotypic Enhancement, Synthetic Rescue, Synthetic Rescue, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Suppression, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Phenotypic Enhancement, Synthetic Rescue, Synthetic Rescue, Phenotypic Suppression
LCD1 YDR499W Essential protein required for the DNA integrity checkpoint pathways physical 26 7 17 Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Two-hybrid, Co-localization, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Biochemical Activity, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-MS, Reconstituted Complex, Affinity Capture-MS, Biochemical Activity, Two-hybrid, Affinity Capture-Western, Co-crystal Structure, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS
SAE2 YGL175C Endonuclease required for telomere elongation genetic 14 5 11 Dosage Lethality, Dosage Growth Defect, Synthetic Rescue, Phenotypic Suppression, Phenotypic Enhancement, Synthetic Rescue, Synthetic Rescue, Phenotypic Suppression, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue
RFA1 YAR007C Subunit of heterotrimeric Replication Protein A (RPA) physical 14 4 11 Affinity Capture-MS, Affinity Capture-Western, Two-hybrid, Affinity Capture-Western, Biochemical Activity, Biochemical Activity, Affinity Capture-MS, Biochemical Activity, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Biochemical Activity, Affinity Capture-MS, Affinity Capture-Western
RAD53 YPL153C DNA damage response kinase physical 12 2 11 Affinity Capture-Western, Biochemical Activity, Biochemical Activity, Biochemical Activity, Biochemical Activity, Affinity Capture-Western, Biochemical Activity, Biochemical Activity, Biochemical Activity, Biochemical Activity, Biochemical Activity, Biochemical Activity
RFA2 YNL312W Subunit of heterotrimeric Replication Protein A (RPA) physical 10 4 8 Affinity Capture-Western, Two-hybrid, Affinity Capture-Western, Biochemical Activity, Biochemical Activity, Biochemical Activity, Biochemical Activity, Affinity Capture-MS, Biochemical Activity, Biochemical Activity
EXO1 YOR033C 5'-3' exonuclease and flap-endonuclease genetic 8 4 7 Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Suppression, Synthetic Rescue, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Rescue
RAD50 YNL250W Subunit of MRX complex with Mre11p and Xrs2p genetic 7 5 7 Synthetic Lethality, Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Rescue, Synthetic Growth Defect, Synthetic Lethality, Phenotypic Suppression
RAD53 YPL153C DNA damage response kinase genetic 7 5 5 Synthetic Lethality, Phenotypic Enhancement, Dosage Rescue, Synthetic Rescue, Synthetic Rescue, Phenotypic Suppression, Phenotypic Suppression
XRS2 YDR369C FHA domain-containing component of the Mre11 complex genetic 6 5 6 Phenotypic Enhancement, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Synthetic Rescue, Synthetic Lethality
RAD9 YDR217C DNA damage-dependent checkpoint protein genetic 6 4 6 Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Suppression, Negative Genetic, Negative Genetic, Synthetic Growth Defect
MRE11 YMR224C Nuclease subunit of the MRX complex with Rad50p and Xrs2p genetic 6 4 6 Phenotypic Suppression, Phenotypic Suppression, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Lethality, Phenotypic Suppression
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 6 3 6 Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Rescue, Synthetic Growth Defect, Synthetic Growth Defect
CDC13 YDL220C Single stranded DNA-binding protein found at TG1-3 telomere G-tails genetic 6 4 5 Synthetic Rescue, Synthetic Growth Defect, Synthetic Rescue, Phenotypic Enhancement, Phenotypic Suppression, Synthetic Rescue
RAD52 YML032C Protein involved in homologous recombination genetic 5 4 5 Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Rescue, Phenotypic Enhancement
SRS2 YJL092W DNA helicase and DNA-dependent ATPase genetic 5 4 5 Synthetic Rescue, Synthetic Growth Defect, Synthetic Growth Defect, Dosage Lethality, Negative Genetic
RAD51 YER095W Strand exchange protein genetic 5 4 5 Phenotypic Enhancement, Phenotypic Suppression, Synthetic Growth Defect, Positive Genetic, Synthetic Growth Defect
ASF1 YJL115W Nucleosome assembly factor genetic 5 3 4 Phenotypic Enhancement, Synthetic Rescue, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect
RFX1 YLR176C Major transcriptional repressor of DNA-damage-regulated genes genetic 5 3 4 Dosage Lethality, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Phenotypic Enhancement
MMS21 YEL019C Highly conserved SUMO E3 ligase subunit of SMC5-SMC6 complex genetic 5 3 4 Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Suppression, Phenotypic Enhancement, Phenotypic Suppression
DNA2 YHR164C ATP-dependent 5'-flap endonuclease and DNA helicase genetic 4 4 4 Synthetic Lethality, Positive Genetic, Synthetic Growth Defect, Phenotypic Suppression
HTZ1 YOL012C Histone variant H2AZ genetic 4 3 4 Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Phenotypic Enhancement
CHK1 YBR274W Serine/threonine kinase and DNA damage checkpoint effector genetic 4 3 4 Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Suppression
RLF2 YPR018W Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1) genetic 4 2 4 Phenotypic Enhancement, Synthetic Lethality, Phenotypic Enhancement, Phenotypic Enhancement
RRM3 YHR031C DNA helicase involved in rDNA replication and Ty1 transposition genetic 4 2 4 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Rescue
CTF4 YPR135W Chromatin-associated protein genetic 4 2 4 Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect
RNR1 YER070W Major isoform of large subunit of ribonucleotide-diphosphate reductase genetic 4 1 4 Dosage Rescue, Dosage Rescue, Dosage Rescue, Dosage Rescue
HHF2 YNL030W Histone H4 genetic 4 3 3 Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Rescue, Phenotypic Enhancement
SMC6 YLR383W Subunit of the SMC5-SMC6 complex genetic 3 3 3 Phenotypic Enhancement, Synthetic Rescue, Phenotypic Suppression
ELG1 YOR144C Subunit of an alternative replication factor C complex genetic 3 3 3 Phenotypic Enhancement, Synthetic Growth Defect, Negative Genetic
CLB5 YPR120C B-type cyclin involved in DNA replication during S phase genetic 3 3 3 Dosage Lethality, Synthetic Lethality, Synthetic Growth Defect
DBF4 YDR052C Regulatory subunit of Cdc7p-Dbf4p kinase complex genetic 3 3 3 Synthetic Lethality, Synthetic Rescue, Negative Genetic
CTF18 YMR078C Subunit of a complex with Ctf8p genetic 3 2 3 Phenotypic Suppression, Negative Genetic, Phenotypic Suppression
MRC1 YCL061C S-phase checkpoint protein required for DNA replication genetic 3 2 3 Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect
PPH3 YDR075W Catalytic subunit of protein phosphatase PP4 complex genetic 3 2 3 Phenotypic Suppression, Phenotypic Suppression, Positive Genetic
DIA2 YOR080W Origin-binding F-box protein genetic 3 2 3 Synthetic Lethality, Synthetic Lethality, Negative Genetic
CLB2 YPR119W B-type cyclin involved in cell cycle progression genetic 3 2 3 Phenotypic Enhancement, Synthetic Rescue, Synthetic Rescue
CLN2 YPL256C G1 cyclin involved in regulation of the cell cycle genetic 3 2 3 Dosage Lethality, Dosage Lethality, Synthetic Rescue
HST3 YOR025W Sirtuin, histone H3 deacetylase genetic 3 2 3 Synthetic Lethality, Negative Genetic, Synthetic Lethality
YKU70 YMR284W Subunit of the telomeric Ku complex (Yku70p-Yku80p) genetic 3 1 3 Synthetic Rescue, Synthetic Rescue, Synthetic Rescue
RAD18 YCR066W E3 ubiquitin ligase genetic 3 1 3 Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect
TEL2 YGR099W Subunit of the ASTRA complex, involved in chromatin remodeling genetic 3 3 2 Synthetic Growth Defect, Phenotypic Enhancement, Negative Genetic
NHP10 YDL002C Non-essential INO80 chromatin remodeling complex subunit genetic 3 3 2 Phenotypic Suppression, Synthetic Rescue, Negative Genetic
RAD1 YPL022W Single-stranded DNA endonuclease (with Rad10p) genetic 3 3 2 Phenotypic Enhancement, Synthetic Lethality, Phenotypic Suppression
PTC2 YER089C Type 2C protein phosphatase (PP2C) genetic 3 3 2 Dosage Lethality, Synthetic Rescue, Phenotypic Suppression
SGV1 YPR161C Cyclin (Bur2p)-dependent protein kinase genetic 3 3 2 Synthetic Growth Defect, Synthetic Rescue, Negative Genetic
DIF1 YLR437C Protein that regulates nuclear import of Rnr2p and Rnr4p genetic 3 3 2 Dosage Lethality, Synthetic Rescue, Phenotypic Enhancement
CDC73 YLR418C Component of the Paf1p complex genetic 3 2 2 Negative Genetic, Negative Genetic, Synthetic Growth Defect
ISW2 YOR304W ATP-dependent DNA translocase involved in chromatin remodeling genetic 3 2 2 Phenotypic Suppression, Phenotypic Suppression, Synthetic Rescue
RTF1 YGL244W Subunit of RNAPII-associated chromatin remodeling Paf1 complex genetic 3 2 2 Negative Genetic, Negative Genetic, Synthetic Growth Defect
IES4 YOR189W Component of the INO80 chromatiin remodeling complex physical 3 2 2 Biochemical Activity, Affinity Capture-MS, Biochemical Activity
HUG1 YML058W-A Ribonucleotide reductase inhibitor genetic 3 2 2 Dosage Lethality, Synthetic Rescue, Synthetic Rescue
SNF2 YOR290C Catalytic subunit of the SWI/SNF chromatin remodeling complex physical 3 2 1 Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS
INO80 YGL150C Nucleosome spacing factor physical 3 2 1 Affinity Capture-MS, Affinity Capture-MS, Biochemical Activity
BRE1 YDL074C E3 ubiquitin ligase genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
HPR1 YDR138W Subunit of THO/TREX complexes genetic 2 2 2 Synthetic Growth Defect, Synthetic Rescue
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit genetic 2 2 2 Phenotypic Enhancement, Synthetic Rescue
RFA1 YAR007C Subunit of heterotrimeric Replication Protein A (RPA) genetic 2 2 2 Negative Genetic, Synthetic Lethality
RAD14 YMR201C Subunit of Nucleotide Excision Repair Factor 1 (NEF1) genetic 2 2 2 Phenotypic Enhancement, Synthetic Growth Defect
SIN3 YOL004W Component of both the Rpd3S and Rpd3L histone deacetylase complexes genetic 2 2 2 Synthetic Rescue, Negative Genetic
RAD59 YDL059C Protein involved DNA double-strand break repair genetic 2 2 2 Phenotypic Enhancement, Negative Genetic
SIZ1 YDR409W SUMO E3 ligase genetic 2 2 2 Synthetic Rescue, Synthetic Growth Defect
RTT101 YJL047C Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex genetic 2 2 2 Phenotypic Suppression, Synthetic Rescue
UBC9 YDL064W SUMO-conjugating enzyme involved in the Smt3p conjugation pathway genetic 2 2 2 Synthetic Lethality, Synthetic Growth Defect
PRI1 YIR008C Subunit of DNA primase genetic 2 2 2 Synthetic Lethality, Negative Genetic
RTT109 YLL002W Histone acetyltransferase genetic 2 2 2 Phenotypic Suppression, Synthetic Rescue
TSA1 YML028W Thioredoxin peroxidase genetic 2 2 2 Synthetic Lethality, Synthetic Growth Defect
SET2 YJL168C Histone methyltransferase with a role in transcriptional elongation genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
POL32 YJR043C Third subunit of DNA polymerase delta genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
MUS81 YDR386W Subunit of structure-specific Mms4p-Mus81p endonuclease genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
PCH2 YBR186W Hexameric ring ATPase that remodels chromosome axis protein Hop1p genetic 2 2 2 Synthetic Growth Defect, Phenotypic Enhancement
POL3 YDL102W Catalytic subunit of DNA polymerase delta genetic 2 2 2 Synthetic Lethality, Negative Genetic
RTT106 YNL206C Histone chaperone genetic 2 2 2 Synthetic Growth Defect, Phenotypic Enhancement
MPH1 YIR002C 3'-5' DNA helicase involved in error-free bypass of DNA lesions genetic 2 2 2 Phenotypic Suppression, Negative Genetic
POL1 YNL102W Catalytic subunit of the DNA polymerase I alpha-primase complex genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
SLX8 YER116C Subunit of Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex genetic 2 2 2 Negative Genetic, Positive Genetic
CDC6 YJL194W Essential ATP-binding protein required for DNA replication genetic 2 2 2 Synthetic Lethality, Negative Genetic
DUN1 YDL101C Cell-cycle checkpoint S/T protein kinase genetic 2 2 2 Phenotypic Enhancement, Synthetic Rescue
DMC1 YER179W Meiosis-specific recombinase required for double-strand break repair genetic 2 2 2 Synthetic Rescue, Phenotypic Suppression
CIN8 YEL061C Bipolar kinesin motor protein genetic 2 2 2 Phenotypic Enhancement, Synthetic Rescue
CDC7 YDL017W S/T kinase and catalytic subunit of DDK (Dbf4-dependent kinase) genetic 2 2 2 Synthetic Lethality, Negative Genetic
MCM10 YIL150C Essential chromatin-associated protein genetic 2 2 2 Synthetic Lethality, Negative Genetic
CSM3 YMR048W Replication fork associated factor genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
ARP6 YLR085C Actin-related protein that binds nucleosomes genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
APN1 YKL114C Major apurinic/apyrimidinic endonuclease genetic 2 2 2 Synthetic Lethality, Phenotypic Suppression
BUB1 YGR188C Protein kinase involved in the cell cycle checkpoint into anaphase genetic 2 2 2 Phenotypic Suppression, Phenotypic Enhancement
CTF8 YHR191C Subunit of a complex with Ctf18p genetic 2 2 2 Phenotypic Suppression, Negative Genetic
DCC1 YCL016C Subunit of a complex with Ctf8p and Ctf18p genetic 2 2 2 Phenotypic Suppression, Negative Genetic
IRC21 YMR073C Protein of unknown function genetic 2 2 2 Positive Genetic, Synthetic Rescue
MSH6 YDR097C Protein required for mismatch repair in mitosis and meiosis physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
SUP45 YBR143C Polypeptide release factor (eRF1) in translation termination physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
STI1 YOR027W Evolutionarily-conserved Hsp90 cochaperone physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
RFA3 YJL173C Subunit of heterotrimeric Replication Protein A (RPA) physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
RAD55 YDR076W Protein that stimulates strand exchange physical 2 1 2 Biochemical Activity, Biochemical Activity
TEL2 YGR099W Subunit of the ASTRA complex, involved in chromatin remodeling physical 2 1 2 Affinity Capture-Western, Affinity Capture-Western
SGS1 YMR190C RecQ family nucleolar DNA helicase physical 2 1 2 Biochemical Activity, Biochemical Activity
SET1 YHR119W Histone methyltransferase, subunit of the COMPASS (Set1C) complex genetic 2 1 2 Synthetic Rescue, Synthetic Rescue
RAD5 YLR032W DNA helicase/Ubiquitin ligase genetic 2 1 2 Synthetic Growth Defect, Synthetic Growth Defect
TOF1 YNL273W Subunit of a replication-pausing checkpoint complex genetic 2 1 2 Synthetic Growth Defect, Synthetic Growth Defect
MMS2 YGL087C Ubiquitin-conjugating enzyme variant genetic 2 1 2 Synthetic Growth Defect, Synthetic Growth Defect
RDH54 YBR073W DNA-dependent ATPase genetic 2 1 2 Phenotypic Suppression, Phenotypic Suppression
SWR1 YDR334W Swi2/Snf2-related ATPase genetic 2 1 2 Negative Genetic, Negative Genetic
CDC13 YDL220C Single stranded DNA-binding protein found at TG1-3 telomere G-tails physical 2 1 2 Biochemical Activity, Biochemical Activity
CLN1 YMR199W G1 cyclin involved in regulation of the cell cycle genetic 2 1 2 Dosage Lethality, Dosage Lethality
DPB11 YJL090C DNA replication initiation protein physical 2 1 2 Reconstituted Complex, Reconstituted Complex
DPB11 YJL090C DNA replication initiation protein genetic 2 1 2 Negative Genetic, Negative Genetic
MCK1 YNL307C Dual-specificity ser/thr and tyrosine protein kinase genetic 2 1 2 Dosage Rescue, Dosage Rescue
MAD2 YJL030W Component of the spindle-assembly checkpoint complex genetic 2 1 2 Phenotypic Suppression, Phenotypic Suppression
HST4 YDR191W NAD(+)-dependent protein deacetylase genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
CHD1 YER164W Chromatin remodeler that regulates various aspects of transcription genetic 2 2 1 Synthetic Rescue, Synthetic Growth Defect
LEO1 YOR123C Component of the Paf1 complex physical 2 2 1 Affinity Capture-MS, Biochemical Activity
RPA135 YPR010C RNA polymerase I second largest subunit A135 physical 2 2 1 Reconstituted Complex, Biochemical Activity
RTF1 YGL244W Subunit of RNAPII-associated chromatin remodeling Paf1 complex physical 2 2 1 Affinity Capture-MS, Biochemical Activity
PAF1 YBR279W Component of the Paf1p complex involved in transcription elongation physical 2 2 1 Affinity Capture-MS, Biochemical Activity
POB3 YML069W Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) genetic 2 2 1 Synthetic Growth Defect, Dosage Rescue
RAD10 YML095C Single-stranded DNA endonuclease (with Rad1p) genetic 2 2 1 Phenotypic Enhancement, Synthetic Lethality
RPN3 YER021W Essential non-ATPase regulatory subunit of the 26S proteasome lid genetic 2 2 1 Synthetic Rescue, Synthetic Growth Defect
RTT107 YHR154W BRCA1 C-terminal domain protein needed for recovery from DNA damage genetic 2 2 1 Phenotypic Suppression, Synthetic Rescue
ATG1 YGL180W Protein serine/threonine kinase physical 2 2 1 Affinity Capture-MS, Affinity Capture-Western
IES2 YNL215W Protein that associates with the INO80 chromatin remodeling complex genetic 2 2 1 Negative Genetic, Synthetic Growth Defect
GGC1 YDL198C Mitochondrial GTP/GDP transporter physical 2 2 1 Affinity Capture-MS, Affinity Capture-Western
BUL2 YML111W Alpha-arrestin, component of the Rsp5p E3-ubiquitin ligase complex physical 2 1 1 Affinity Capture-MS, Affinity Capture-MS
FKH1 YIL131C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SPT10 YJL127C Histone H3 acetylase with a role in transcriptional regulation regulation 1 1 1 DNA to cDNA expression microarray evidence
FKH2 YNL068C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
UME6 YDR207C Rpd3L histone deacetylase complex subunit regulation 1 1 1 chromatin immunoprecipitation-chip evidence
RAD53 YPL153C DNA damage response kinase regulation 1 1 1 qualitative western immunoblotting evidence
LCD1 YDR499W Essential protein required for the DNA integrity checkpoint pathways regulation 1 1 1 qualitative western immunoblotting evidence
MEC1 YBR136W Genome integrity checkpoint protein and PI kinase superfamily member regulation 1 1 1 protein kinase assay evidence
MMS21 YEL019C Highly conserved SUMO E3 ligase subunit of SMC5-SMC6 complex regulation 1 1 1 qualitative western immunoblotting evidence
DIF1 YLR437C Protein that regulates nuclear import of Rnr2p and Rnr4p regulation 1 1 1 qualitative western immunoblotting evidence
CDC73 YLR418C Component of the Paf1p complex physical 1 1 1 Affinity Capture-MS
CTR9 YOL145C Component of the Paf1p complex involved in transcription elongation physical 1 1 1 Affinity Capture-MS
LEO1 YOR123C Component of the Paf1 complex genetic 1 1 1 Synthetic Growth Defect
ARP4 YJL081C Nuclear actin-related protein involved in chromatin remodeling physical 1 1 1 Affinity Capture-MS
GUS1 YGL245W Glutamyl-tRNA synthetase (GluRS) physical 1 1 1 Affinity Capture-MS
BMH1 YER177W 14-3-3 protein, major isoform genetic 1 1 1 Synthetic Rescue
ARP7 YPR034W Component of both the SWI/SNF and RSC chromatin remodeling complexes genetic 1 1 1 Negative Genetic
ARP9 YMR033W Component of both the SWI/SNF and RSC chromatin remodeling complexes genetic 1 1 1 Negative Genetic
GCD1 YOR260W Gamma subunit of the translation initiation factor eIF2B physical 1 1 1 Affinity Capture-MS
ACT1 YFL039C Actin, structural protein in cytoskeleton genetic 1 1 1 Negative Genetic
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex genetic 1 1 1 Synthetic Lethality
CDC14 YFR028C Protein phosphatase required for mitotic exit genetic 1 1 1 Synthetic Growth Defect
CDC12 YHR107C Component of the septin ring that is required for cytokinesis genetic 1 1 1 Synthetic Growth Defect
CDC45 YLR103C DNA replication initiation factor genetic 1 1 1 Negative Genetic
ERG26 YGL001C C-3 sterol dehydrogenase genetic 1 1 1 Negative Genetic
CTK1 YKL139W Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I) genetic 1 1 1 Negative Genetic
DOA1 YKL213C WD-repeat protein involved in ubiquitin-mediated protein degradation genetic 1 1 1 Negative Genetic
CDC16 YKL022C Subunit of the anaphase-promoting complex/cyclosome (APC/C) genetic 1 1 1 Phenotypic Enhancement
CDC23 YHR166C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 1 1 1 Phenotypic Enhancement
FIP1 YJR093C Subunit of cleavage polyadenylation factor (CPF) genetic 1 1 1 Negative Genetic
HHF1 YBR009C Histone H4 genetic 1 1 1 Synthetic Growth Defect
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator genetic 1 1 1 Synthetic Growth Defect
IST1 YNL265C Protein with positive role in the multivesicular body sorting pathway physical 1 1 1 Affinity Capture-MS
CLU1 YMR012W Subunit of the eukaryotic translation initiation factor 3 (eIF3) physical 1 1 1 Affinity Capture-MS
LAS17 YOR181W Actin assembly factor physical 1 1 1 Affinity Capture-MS
MAL12 YGR292W Maltase (alpha-D-glucosidase) genetic 1 1 1 Positive Genetic
LCD1 YDR499W Essential protein required for the DNA integrity checkpoint pathways genetic 1 1 1 Phenotypic Suppression
MSL1 YIR009W U2B component of U2 snRNP physical 1 1 1 Two-hybrid
RAD9 YDR217C DNA damage-dependent checkpoint protein physical 1 1 1 Biochemical Activity
TRM732 YMR259C Protein involved in 2'-O-methylation of C32 of substrate tRNAs physical 1 1 1 Affinity Capture-MS
RPB10 YOR210W RNA polymerase subunit ABC10-beta physical 1 1 1 Affinity Capture-MS
RAD55 YDR076W Protein that stimulates strand exchange genetic 1 1 1 Synthetic Growth Defect
SLA1 YBL007C Cytoskeletal protein binding protein physical 1 1 1 Two-hybrid
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-RNA
SNF7 YLR025W One of four subunits of the ESCRT-III complex physical 1 1 1 Affinity Capture-MS
YCP4 YCR004C Protein of unknown function physical 1 1 1 Affinity Capture-MS
SPT7 YBR081C Subunit of the SAGA transcriptional regulatory complex physical 1 1 1 Affinity Capture-MS
SGF73 YGL066W Subunit of DUBm module of SAGA and SLIK physical 1 1 1 Affinity Capture-MS
MRC1 YCL061C S-phase checkpoint protein required for DNA replication physical 1 1 1 Biochemical Activity
SMT3 YDR510W Ubiquitin-like protein of the SUMO family physical 1 1 1 Protein-peptide
REC114 YMR133W Protein involved in early stages of meiotic recombination physical 1 1 1 Biochemical Activity
VAM6 YDL077C Guanine nucleotide exchange factor for the GTPase Gtr1p physical 1 1 1 Affinity Capture-MS
PUF3 YLL013C Protein of the mitochondrial outer surface physical 1 1 1 Affinity Capture-RNA
RVB1 YDR190C ATP-dependent DNA helicase, also known as pontin physical 1 1 1 Affinity Capture-MS
RVB2 YPL235W ATP-dependent DNA helicase, also known as reptin physical 1 1 1 Affinity Capture-MS
TAF14 YPL129W Subunit of TFIID, TFIIF, INO80, SWI/SNF, and NuA3 complexes physical 1 1 1 Affinity Capture-MS
TAF14 YPL129W Subunit of TFIID, TFIIF, INO80, SWI/SNF, and NuA3 complexes genetic 1 1 1 Dosage Rescue
NHP10 YDL002C Non-essential INO80 chromatin remodeling complex subunit physical 1 1 1 Affinity Capture-MS
MEC1 YBR136W Genome integrity checkpoint protein and PI kinase superfamily member physical 1 1 1 Biochemical Activity
RAP1 YNL216W Essential DNA-binding transcription regulator that binds many loci physical 1 1 1 Biochemical Activity
RAP1 YNL216W Essential DNA-binding transcription regulator that binds many loci genetic 1 1 1 Dosage Lethality
MOG1 YJR074W Conserved nuclear protein that interacts with GTP-Gsp1p physical 1 1 1 Affinity Capture-MS
MPS3 YJL019W Nuclear envelope protein physical 1 1 1 Affinity Capture-MS
MEK1 YOR351C Meiosis-specific serine/threonine protein kinase physical 1 1 1 Biochemical Activity
SNF1 YDR477W AMP-activated S/T protein kinase physical 1 1 1 Biochemical Activity
RCK1 YGL158W Protein kinase involved in oxidative stress response genetic 1 1 1 Dosage Lethality
RCK2 YLR248W Protein kinase involved in response to oxidative and osmotic stress genetic 1 1 1 Dosage Lethality
SCS2 YER120W Integral ER membrane protein, regulates phospholipid metabolism genetic 1 1 1 Dosage Rescue
PDS1 YDR113C Securin genetic 1 1 1 Phenotypic Enhancement
RPD3 YNL330C Histone deacetylase, component of both the Rpd3S and Rpd3L complexes genetic 1 1 1 Synthetic Rescue
SIC1 YLR079W Cyclin-dependent kinase inhibitor (CKI) genetic 1 1 1 Synthetic Growth Defect
MND1 YGL183C Protein required for recombination and meiotic nuclear division genetic 1 1 1 Phenotypic Suppression
STU2 YLR045C Microtubule polymerase of the XMAP215/Dis1 family genetic 1 1 1 Phenotypic Enhancement
RNR4 YGR180C Ribonucleotide-diphosphate reductase (RNR) small subunit genetic 1 1 1 Synthetic Lethality
ORC6 YHR118C Subunit of the origin recognition complex (ORC) genetic 1 1 1 Synthetic Lethality
WTM2 YOR229W Transcriptional modulator genetic 1 1 1 Dosage Rescue
WTM1 YOR230W Transcriptional modulator genetic 1 1 1 Phenotypic Enhancement
NRM1 YNR009W Transcriptional co-repressor of MBF-regulated gene expression genetic 1 1 1 Synthetic Rescue
MGS1 YNL218W Protein with DNA-dependent ATPase and ssDNA annealing activities genetic 1 1 1 Dosage Lethality
SSZ1 YHR064C Hsp70 protein that interacts with Zuo1p (a DnaJ homolog) genetic 1 1 1 Dosage Rescue
SRL3 YKR091W Repressor of transcription at Start genetic 1 1 1 Dosage Rescue
SRL1 YOR247W Mannoprotein that exhibits a tight association with the cell wall genetic 1 1 1 Dosage Rescue
RPT4 YOR259C ATPase of the 19S regulatory particle of the 26S proteasome genetic 1 1 1 Dosage Rescue
RPN8 YOR261C Essential non-ATPase regulatory subunit of the 26S proteasome genetic 1 1 1 Dosage Rescue
PIN4 YBL051C Protein involved in G2/M phase progression and response to DNA damage genetic 1 1 1 Phenotypic Enhancement
PSY2 YNL201C Subunit of protein phosphatase PP4 complex genetic 1 1 1 Phenotypic Suppression
ORC2 YBR060C Subunit of the origin recognition complex (ORC) genetic 1 1 1 Synthetic Rescue
RNR3 YIL066C Minor isoform of large subunit of ribonucleotide-diphosphate reductase genetic 1 1 1 Dosage Rescue
SRL2 YLR082C Protein of unknown function genetic 1 1 1 Dosage Rescue
RSC2 YLR357W Component of the RSC chromatin remodeling complex genetic 1 1 1 Synthetic Growth Defect
PLC1 YPL268W Phospholipase C genetic 1 1 1 Negative Genetic
RAD30 YDR419W DNA polymerase eta genetic 1 1 1 Phenotypic Enhancement
POL30 YBR088C Proliferating cell nuclear antigen (PCNA) genetic 1 1 1 Phenotypic Enhancement
RAD26 YJR035W Protein involved in transcription-coupled nucleotide excision repair genetic 1 1 1 Phenotypic Suppression
MET32 YDR253C Zinc-finger DNA-binding transcription factor genetic 1 1 1 Synthetic Growth Defect
TPK2 YPL203W cAMP-dependent protein kinase catalytic subunit genetic 1 1 1 Dosage Rescue
TPK1 YJL164C cAMP-dependent protein kinase catalytic subunit genetic 1 1 1 Dosage Rescue
RPN4 YDL020C Transcription factor that stimulates expression of proteasome genes genetic 1 1 1 Synthetic Growth Defect
SPT16 YGL207W Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) genetic 1 1 1 Synthetic Growth Defect
SWC5 YBR231C Component of the SWR1 complex genetic 1 1 1 Synthetic Growth Defect
YAP1 YML007W Basic leucine zipper (bZIP) transcription factor genetic 1 1 1 Synthetic Growth Defect
RAD27 YKL113C 5' to 3' exonuclease, 5' flap endonuclease genetic 1 1 1 Synthetic Lethality
SEC7 YDR170C Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors genetic 1 1 1 Synthetic Growth Defect
SEC1 YDR164C Sm-like protein involved in docking and fusion of exocytic vesicles genetic 1 1 1 Synthetic Lethality
SAC3 YDR159W mRNA export factor genetic 1 1 1 Synthetic Rescue
THP1 YOL072W Nuclear pore-associated protein genetic 1 1 1 Synthetic Rescue
SUS1 YBR111W-A Global transcriptional regulator, component of SAGA, TREX-2 complexes genetic 1 1 1 Synthetic Rescue
THP2 YHR167W Subunit of the THO and TREX complexes genetic 1 1 1 Synthetic Rescue
THO2 YNL139C Subunit of the THO complex genetic 1 1 1 Synthetic Rescue
MFT1 YML062C Subunit of the THO complex genetic 1 1 1 Synthetic Rescue
NUP1 YOR098C FG-nucleoporin component of central core of the nuclear pore complex genetic 1 1 1 Synthetic Rescue
MLP1 YKR095W Myosin-like protein associated with the nuclear envelope genetic 1 1 1 Synthetic Rescue
NFI1 YOR156C SUMO E3 ligase genetic 1 1 1 Synthetic Growth Defect
PMR1 YGL167C High affinity Ca2+/Mn2+ P-type ATPase genetic 1 1 1 Synthetic Rescue
TOP2 YNL088W Topoisomerase II genetic 1 1 1 Phenotypic Suppression
YCG1 YDR325W Subunit of the condensin complex genetic 1 1 1 Phenotypic Suppression
NTG1 YAL015C DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase genetic 1 1 1 Phenotypic Suppression
NTG2 YOL043C DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase genetic 1 1 1 Phenotypic Suppression
SPO11 YHL022C Meiosis-specific protein required for meiotic recombination genetic 1 1 1 Phenotypic Suppression
NDT80 YHR124W Meiosis-specific transcription factor genetic 1 1 1 Phenotypic Suppression
YBP2 YGL060W Central kinetochore associated protein genetic 1 1 1 Positive Genetic
YPS5 YGL259W Protein with similarity to GPI-anchored aspartic proteases genetic 1 1 1 Positive Genetic
NMD2 YHR077C Protein involved in the nonsense-mediated mRNA decay (NMD) pathway genetic 1 1 1 Positive Genetic
PRM10 YJL108C Pheromone-regulated protein genetic 1 1 1 Positive Genetic
XDJ1 YLR090W Chaperone with a role in facilitating mitochondrial protein import genetic 1 1 1 Positive Genetic
NIP100 YPL174C Large subunit of the dynactin complex genetic 1 1 1 Positive Genetic
POL12 YBL035C B subunit of DNA polymerase alpha-primase complex genetic 1 1 1 Negative Genetic
QRI1 YDL103C UDP-N-acetylglucosamine pyrophosphorylase genetic 1 1 1 Negative Genetic
PSF1 YDR013W Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) genetic 1 1 1 Negative Genetic
STN1 YDR082W Telomere end-binding and capping protein genetic 1 1 1 Negative Genetic
SLD5 YDR489W Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) genetic 1 1 1 Negative Genetic
PRE4 YFR050C Beta 7 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
SLD3 YGL113W Protein involved in the initiation of DNA replication genetic 1 1 1 Negative Genetic
PSF2 YJL072C Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) genetic 1 1 1 Negative Genetic
POL31 YJR006W Subunit of DNA polymerase delta (polymerase III) genetic 1 1 1 Negative Genetic
PRI2 YKL045W Subunit of DNA primase genetic 1 1 1 Negative Genetic
NSE1 YLR007W Component of the SMC5-SMC6 complex genetic 1 1 1 Negative Genetic
RFC4 YOL094C Subunit of heteropentameric Replication factor C (RF-C) genetic 1 1 1 Negative Genetic
PUP1 YOR157C Beta 2 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
PRE10 YOR362C Alpha 7 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
PRE2 YPR103W Beta 5 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
ORC4 YPR162C Subunit of the origin recognition complex (ORC) genetic 1 1 1 Negative Genetic
SWC3 YAL011W Protein of unknown function genetic 1 1 1 Negative Genetic
URA7 YBL039C Major CTP synthase isozyme (see also URA8) genetic 1 1 1 Negative Genetic
STE50 YCL032W Adaptor protein for various signaling pathways genetic 1 1 1 Negative Genetic
RIM1 YCR028C-A ssDNA-binding protein essential for mitochondrial genome maintenance genetic 1 1 1 Negative Genetic
PAT1 YCR077C Deadenylation-dependent mRNA-decapping factor genetic 1 1 1 Negative Genetic
SLX5 YDL013W Subunit of the Slx5-Slx8 SUMO-targeted Ub ligase (STUbL) complex genetic 1 1 1 Negative Genetic
VPS72 YDR485C Htz1p-binding component of the SWR1 complex genetic 1 1 1 Negative Genetic
RAD24 YER173W Checkpoint protein genetic 1 1 1 Negative Genetic
SNF4 YGL115W Activating gamma subunit of the AMP-activated Snf1p kinase complex genetic 1 1 1 Negative Genetic
VMA21 YGR105W Integral membrane protein required for V-ATPase function genetic 1 1 1 Negative Genetic
PIH1 YHR034C Component of the conserved R2TP complex (Rvb1-Rvb2-Tah1-Pih1) genetic 1 1 1 Negative Genetic
SOL3 YHR163W 6-phosphogluconolactonase genetic 1 1 1 Negative Genetic
PAM17 YKR065C Constituent of the TIM23 complex genetic 1 1 1 Negative Genetic
MLH1 YMR167W Protein required for mismatch repair in mitosis and meiosis genetic 1 1 1 Negative Genetic
TDA1 YMR291W Protein kinase of unknown cellular role genetic 1 1 1 Negative Genetic
YDJ1 YNL064C Type I HSP40 co-chaperone genetic 1 1 1 Negative Genetic
OCA1 YNL099C Putative protein tyrosine phosphatase genetic 1 1 1 Negative Genetic
RAD17 YOR368W Checkpoint protein genetic 1 1 1 Negative Genetic
RMI1 YPL024W Subunit of the RecQ (Sgs1p) - Topo III (Top3p) complex genetic 1 1 1 Negative Genetic
POC4 YPL144W Component of a heterodimeric Poc4p-Irc25p chaperone genetic 1 1 1 Negative Genetic
PET20 YPL159C Mitochondrial protein genetic 1 1 1 Negative Genetic
UBA3 YPR066W Protein that activates Rub1p (NEDD8) before neddylation genetic 1 1 1 Negative Genetic
QCR2 YPR191W Subunit 2 of ubiquinol cytochrome-c reductase (Complex III) genetic 1 1 1 Negative Genetic
RPB9 YGL070C RNA polymerase II subunit B12.6 genetic 1 1 1 Negative Genetic
RPA34 YJL148W RNA polymerase I subunit A34.5 genetic 1 1 1 Negative Genetic
STB1 YNL309W Protein with role in regulation of MBF-specific transcription at Start genetic 1 1 1 Negative Genetic
SWI4 YER111C DNA binding component of the SBF complex (Swi4p-Swi6p) genetic 1 1 1 Negative Genetic
SKO1 YNL167C Basic leucine zipper transcription factor of the ATF/CREB family genetic 1 1 1 Negative Genetic
SNF6 YHL025W Subunit of the SWI/SNF chromatin remodeling complex genetic 1 1 1 Negative Genetic
RPN10 YHR200W Proteasome polyubiquitin receptor genetic 1 1 1 Negative Genetic
SEM1 YDR363W-A 19S proteasome regulatory particle lid subcomplex component genetic 1 1 1 Negative Genetic
NUP60 YAR002W FG-nucleoporin component of central core of the nuclear pore complex genetic 1 1 1 Negative Genetic
NUP133 YKR082W Subunit of Nup84p subcomplex of nuclear pore complex (NPC) genetic 1 1 1 Negative Genetic
NUP170 YBL079W Subunit of inner ring of nuclear pore complex (NPC) genetic 1 1 1 Negative Genetic
NUP188 YML103C Subunit of the inner ring of the nuclear pore complex (NPC) genetic 1 1 1 Negative Genetic
RCO1 YMR075W Essential component of the Rpd3S histone deacetylase complex genetic 1 1 1 Negative Genetic
SAS2 YMR127C Histone acetyltransferase (HAT) catalytic subunit of the SAS complex genetic 1 1 1 Negative Genetic
SAS4 YDR181C Subunit of the SAS complex (Sas2p, Sas4p, Sas5p) genetic 1 1 1 Negative Genetic
RAS2 YNL098C GTP-binding protein genetic 1 1 1 Phenotypic Suppression
RRD1 YIL153W Peptidyl-prolyl cis/trans-isomerase genetic 1 1 1 Synthetic Rescue
TIP41 YPR040W Tap42p-interacting protein genetic 1 1 1 Synthetic Rescue
TAP42 YMR028W Essential protein involved in the TOR signaling pathway genetic 1 1 1 Synthetic Rescue
SCS7 YMR272C Sphingolipid alpha-hydroxylase genetic 1 1 1 Synthetic Rescue
SUR2 YDR297W Sphinganine C4-hydroxylase genetic 1 1 1 Synthetic Rescue
PPM1 YDR435C Carboxyl methyltransferase genetic 1 1 1 Synthetic Rescue
SWI3 YJL176C Subunit of the SWI/SNF chromatin remodeling complex genetic 1 1 1 Positive Genetic
SPE2 YOL052C S-adenosylmethionine decarboxylase genetic 1 1 1 Positive Genetic
RPS19B YNL302C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
SPE1 YKL184W Ornithine decarboxylase genetic 1 1 1 Positive Genetic
SCH9 YHR205W AGC family protein kinase genetic 1 1 1 Negative Genetic
VPS30 YPL120W Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II genetic 1 1 1 Positive Genetic
VPS53 YJL029C Component of the GARP (Golgi-associated retrograde protein) complex genetic 1 1 1 Negative Genetic
TPM1 YNL079C Major isoform of tropomyosin genetic 1 1 1 Negative Genetic
NMA111 YNL123W Serine protease and general molecular chaperone genetic 1 1 1 Negative Genetic
RTG3 YBL103C bHLH/Zip transcription factor for retrograde (RTG) and TOR pathways genetic 1 1 1 Negative Genetic
RIO1 YOR119C Serine kinase involved in cell cycle regulation and rDNA integrity genetic 1 1 1 Positive Genetic
VPS74 YDR372C Golgi PI4K effector, PtdIns4P sensor, and retention receptor genetic 1 1 1 Synthetic Rescue
RNR2 YJL026W Ribonucleotide-diphosphate reductase (RNR), small subunit genetic 1 1 1 Phenotypic Enhancement
SLX4 YLR135W Endonuclease involved in processing DNA genetic 1 1 1 Synthetic Rescue
VPS51 YKR020W Component of the GARP (Golgi-associated retrograde protein) complex genetic 1 1 1 Phenotypic Suppression
POL2 YNL262W Catalytic subunit of DNA polymerase (II) epsilon genetic 1 1 1 Synthetic Rescue
ORC5 YNL261W Subunit of the origin recognition complex (ORC) genetic 1 1 1 Synthetic Rescue
ARP8 YOR141C Nuclear actin-related protein involved in chromatin remodeling physical 1 1 1 Affinity Capture-MS
ARP8 YOR141C Nuclear actin-related protein involved in chromatin remodeling genetic 1 1 1 Synthetic Growth Defect
IES5 YER092W Non-essential INO80 chromatin remodeling complex subunit physical 1 1 1 Affinity Capture-MS
IES5 YER092W Non-essential INO80 chromatin remodeling complex subunit genetic 1 1 1 Negative Genetic
IES1 YFL013C Subunit of the INO80 chromatin remodeling complex physical 1 1 1 Affinity Capture-MS
HTA1 YDR225W Histone H2A genetic 1 1 1 Phenotypic Suppression
FYV8 YGR196C Protein of unknown function genetic 1 1 1 Positive Genetic
IWR1 YDL115C RNA polymerase II transport factor, conserved from yeast to humans genetic 1 1 1 Negative Genetic
BZZ1 YHR114W SH3 domain protein implicated in regulating actin polymerization physical 1 1 1 Affinity Capture-MS
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes genetic 1 1 1 Synthetic Growth Defect
HFI1 YPL254W Adaptor protein required for structural integrity of the SAGA complex physical 1 1 1 Affinity Capture-MS
MCM2 YBL023C Protein involved in DNA replication genetic 1 1 1 Synthetic Lethality
FUN30 YAL019W Snf2p family member with ATP-dependent chromatin remodeling activity genetic 1 1 1 Synthetic Rescue
BRE2 YLR015W Subunit of COMPASS (Set1C) complex genetic 1 1 1 Negative Genetic
ACO1 YLR304C Aconitase physical 1 1 1 Affinity Capture-MS
MDH1 YKL085W Mitochondrial malate dehydrogenase physical 1 1 1 Affinity Capture-MS
ASA1 YPR085C Subunit of the ASTRA complex, involved in chromatin remodeling physical 1 1 1 Affinity Capture-Western
ASA1 YPR085C Subunit of the ASTRA complex, involved in chromatin remodeling genetic 1 1 1 Negative Genetic
HTB1 YDR224C Histone H2B genetic 1 1 1 Synthetic Growth Defect
GSP1 YLR293C Ran GTPase genetic 1 1 1 Synthetic Rescue
GID7 YCL039W Subunit of GID Complex that binds directly to central component Vid30p genetic 1 1 1 Negative Genetic
DUN1 YDL101C Cell-cycle checkpoint S/T protein kinase physical 1 1 1 Biochemical Activity
CDC9 YDL164C DNA ligase I found in nucleus and mitochondria genetic 1 1 1 Phenotypic Suppression
CYC8 YBR112C General transcriptional co-repressor genetic 1 1 1 Dosage Rescue
DDC1 YPL194W DNA damage checkpoint protein genetic 1 1 1 Phenotypic Suppression
HHT1 YBR010W Histone H3 genetic 1 1 1 Synthetic Rescue
AHC1 YOR023C Subunit of the Ada histone acetyltransferase complex genetic 1 1 1 Negative Genetic
LIF1 YGL090W Component of the DNA ligase IV complex genetic 1 1 1 Synthetic Rescue
MCM4 YPR019W Essential helicase component of heterohexameric MCM2-7 complexes genetic 1 1 1 Synthetic Growth Defect
BUB3 YOR026W Kinetochore checkpoint WD40 repeat protein genetic 1 1 1 Phenotypic Suppression
GCR2 YNL199C Transcriptional activator of genes involved in glycolysis genetic 1 1 1 Negative Genetic
CDH1 YGL003C Activator of anaphase-promoting complex/cyclosome (APC/C) genetic 1 1 1 Phenotypic Enhancement
DCK1 YLR422W Dock family protein (Dedicator Of CytoKinesis), homolog of human DOCK1 genetic 1 1 1 Negative Genetic
ATG13 YPR185W Regulatory subunit of the Atg1p signaling complex physical 1 1 1 Affinity Capture-Western
GZF3 YJL110C GATA zinc finger protein genetic 1 1 1 Dosage Rescue
INO2 YDR123C Transcription factor genetic 1 1 1 Negative Genetic
MAD3 YJL013C Subunit of spindle-assembly checkpoint complex genetic 1 1 1 Phenotypic Suppression
CDC27 YBL084C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 1 1 1 Phenotypic Enhancement
CLB1 YGR108W B-type cyclin involved in cell cycle progression genetic 1 1 1 Phenotypic Enhancement
BMT5 YIL096C Methyltransferase required for m3U2634 methylation of the 25S rRNA genetic 1 1 1 Positive Genetic
DAL81 YIR023W Positive regulator of genes in multiple nitrogen degradation pathways genetic 1 1 1 Negative Genetic
ARP5 YNL059C Nuclear actin-related protein involved in chromatin remodeling physical 1 1 1 Affinity Capture-MS
IES2 YNL215W Protein that associates with the INO80 chromatin remodeling complex physical 1 1 1 Affinity Capture-MS
IES3 YLR052W Subunit of the INO80 chromatin remodeling complex physical 1 1 1 Affinity Capture-MS
IES6 YEL044W Component of the INO80 chromatin remodeling complex physical 1 1 1 Affinity Capture-MS
CTK2 YJL006C Beta subunit of C-terminal domain kinase I (CTDK-I) genetic 1 1 1 Negative Genetic
ELO3 YLR372W Elongase genetic 1 1 1 Negative Genetic
IOC2 YLR095C Subunit of the Isw1b complex genetic 1 1 1 Negative Genetic
KAR3 YPR141C Minus-end-directed microtubule motor genetic 1 1 1 Negative Genetic
HSF1 YGL073W Trimeric heat shock transcription factor genetic 1 1 1 Negative Genetic
ARG82 YDR173C Inositol polyphosphate multikinase (IPMK) genetic 1 1 1 Dosage Rescue
CAD1 YDR423C AP-1-like basic leucine zipper (bZIP) transcriptional activator genetic 1 1 1 Negative Genetic
HFA1 YMR207C Mitochondrial acetyl-coenzyme A carboxylase genetic 1 1 1 Negative Genetic
DPH6 YLR143W Diphthamide synthetase genetic 1 1 1 Negative Genetic
MAC1 YMR021C Copper-sensing transcription factor genetic 1 1 1 Negative Genetic
MCA1 YOR197W Ca2+-dependent cysteine protease genetic 1 1 1 Negative Genetic
HHT2 YNL031C Histone H3 genetic 1 1 1 Dosage Growth Defect
APN2 YBL019W Class II abasic (AP) endonuclease involved in repair of DNA damage genetic 1 1 1 Synthetic Lethality
MDL1 YLR188W Mitochondrial inner membrane half-type ABC transporter genetic 1 1 1 Positive Genetic
KIP2 YPL155C Kinesin-related motor protein involved in mitotic spindle positioning genetic 1 1 1 Negative Genetic
BOL3 YAL046C Protein involved in Fe-S cluster transfer to mitochondrial clients genetic 1 1 1 Positive Genetic
KCS1 YDR017C Inositol hexakisphosphate and inositol heptakisphosphate kinase genetic 1 1 1 Negative Genetic
AHC2 YCR082W Component of the ADA histone acetyltransferase complex genetic 1 1 1 Negative Genetic
JJJ3 YJR097W Iron-binding protein genetic 1 1 1 Negative Genetic
LGE1 YPL055C Protein involved in histone H2B ubiquitination genetic 1 1 1 Negative Genetic
COX7 YMR256C Subunit VII of cytochrome c oxidase (Complex IV) genetic 1 1 1 Negative Genetic
ERG3 YLR056W C-5 sterol desaturase genetic 1 1 1 Positive Genetic
CDC8 YJR057W Nucleoside monophosphate and nucleoside diphosphate kinase genetic 1 1 1 Negative Genetic
COX12 YLR038C Subunit VIb of cytochrome c oxidase genetic 1 1 1 Negative Genetic
CRT10 YOL063C Protein required for the degradation of mutant 25S rRNAs genetic 1 1 1 Phenotypic Suppression
CLB6 YGR109C B-type cyclin involved in DNA replication during S phase genetic 1 1 1 Synthetic Growth Defect
DFR1 YOR236W Dihydrofolate reductase involved in tetrahydrofolate biosynthesis genetic 1 1 1 Negative Genetic
FLX1 YIL134W Mitochondrial flavin adenine dinucleotide transporter genetic 1 1 1 Negative Genetic
HMI1 YOL095C Mitochondrial inner membrane localized ATP-dependent DNA helicase genetic 1 1 1 Negative Genetic
APQ12 YIL040W Nuclear envelope/ER integral membrane protein genetic 1 1 1 Negative Genetic