Standard name Systematic name Name description Description
POP2 YNR052C Subunit of Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation Subunit of Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation; exonuclease of the DEDD superfamily
Visualize the interactome of POP2
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.961 0.991 0.910
Mito 0.092 NaN NaN
ER NaN NaN 0.104

GFP localization & abundance

GFP localization GFP abundance
cytoplasm, mitochondrion 1520

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
POP2 5 0 0 0 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 30 7 20 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Affinity Capture-Western, Affinity Capture-Western, Two-hybrid, Affinity Capture-Western, Affinity Capture-Western, Co-purification, Co-purification, Co-fractionation, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Two-hybrid, Affinity Capture-MS, Reconstituted Complex, Two-hybrid, Affinity Capture-MS, Affinity Capture-RNA
CDC39 YCR093W Subunit of the CCR4-NOT1 core complex physical 23 7 15 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Two-hybrid, Two-hybrid, Affinity Capture-Western, Co-purification, Affinity Capture-MS, Affinity Capture-MS, Co-purification, PCA, Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, Co-crystal Structure, Two-hybrid, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Co-purification
CAF40 YNL288W Component of the CCR4-NOT transcriptional complex physical 14 4 11 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, PCA, Two-hybrid, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western
MOT2 YER068W Ubiquitin-protein ligase subunit of the CCR4-NOT complex physical 7 4 7 Affinity Capture-Western, Affinity Capture-Western, PCA, Affinity Capture-Western, Affinity Capture-MS, Co-purification, Affinity Capture-MS
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 5 3 4 Affinity Capture-Western, Two-hybrid, Affinity Capture-Western, Affinity Capture-RNA, Affinity Capture-RNA
DUN1 YDL101C Cell-cycle checkpoint S/T protein kinase genetic 5 3 3 Phenotypic Enhancement, Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect
CDC36 YDL165W Component of the CCR4-NOT core complex, involved in mRNA decapping physical 5 2 3 Affinity Capture-Western, Affinity Capture-Western, Two-hybrid, Two-hybrid, Affinity Capture-Western
MPT5 YGL178W mRNA-binding protein of the PUF family physical 4 3 4 Affinity Capture-Western, PCA, Affinity Capture-RNA, Affinity Capture-RNA
MPT5 YGL178W mRNA-binding protein of the PUF family genetic 4 2 3 Dosage Rescue, Synthetic Growth Defect, Dosage Rescue, Synthetic Growth Defect
DBF2 YGR092W Ser/Thr kinase involved in transcription and stress response physical 3 3 3 Affinity Capture-Western, Two-hybrid, Proximity Label-MS
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex genetic 3 2 3 Dosage Rescue, Dosage Rescue, Synthetic Growth Defect
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator genetic 3 2 3 Dosage Rescue, Synthetic Lethality, Dosage Rescue
NOT3 YIL038C Component of the CCR4-NOT core complex, involved in mRNA decapping physical 3 2 3 Affinity Capture-Western, Affinity Capture-Western, PCA
PAB1 YER165W Poly(A) binding protein genetic 3 1 3 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality
CAF130 YGR134W Subunit of the CCR4-NOT transcriptional regulatory complex physical 3 1 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
HEK2 YBL032W RNA binding protein involved in asymmetric localization of ASH1 mRNA genetic 3 1 3 Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect
NOT5 YPR072W Component of the CCR4-NOT core complex, involved in mRNA decapping genetic 3 1 3 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality
RAD52 YML032C Protein involved in homologous recombination genetic 3 3 2 Synthetic Rescue, Synthetic Growth Defect, Synthetic Lethality
CSM1 YCR086W Nucleolar protein that mediates homolog segregation during meiosis I genetic 3 3 2 Negative Genetic, Synthetic Growth Defect, Synthetic Lethality
CDC39 YCR093W Subunit of the CCR4-NOT1 core complex genetic 3 2 2 Synthetic Lethality, Synthetic Lethality, Synthetic Rescue
XRS2 YDR369C FHA domain-containing component of the Mre11 complex genetic 3 2 2 Negative Genetic, Synthetic Lethality, Synthetic Lethality
SRS2 YJL092W DNA helicase and DNA-dependent ATPase genetic 3 2 2 Synthetic Growth Defect, Dosage Lethality, Dosage Lethality
SIR2 YDL042C Conserved NAD+ dependent histone deacetylase of the Sirtuin family genetic 3 2 2 Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement
ARP8 YOR141C Nuclear actin-related protein involved in chromatin remodeling genetic 3 1 2 Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 3 1 2 Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect
PUF4 YGL014W Member of the PUF protein family physical 2 2 2 Affinity Capture-Western, Affinity Capture-RNA
DEF1 YKL054C RNAPII degradation factor physical 2 2 2 PCA, Affinity Capture-MS
KAR3 YPR141C Minus-end-directed microtubule motor genetic 2 2 2 Negative Genetic, Synthetic Lethality
MOG1 YJR074W Conserved nuclear protein that interacts with GTP-Gsp1p genetic 2 2 2 Negative Genetic, Synthetic Lethality
ERG2 YMR202W C-8 sterol isomerase genetic 2 2 2 Negative Genetic, Synthetic Lethality
MOT3 YMR070W Transcriptional repressor, activator genetic 2 2 2 Negative Genetic, Synthetic Lethality
PHO92 YDR374C Posttranscriptional regulator of phosphate and glucose metabolism physical 2 2 2 Two-hybrid, Affinity Capture-Western
CDC36 YDL165W Component of the CCR4-NOT core complex, involved in mRNA decapping genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
POL1 YNL102W Catalytic subunit of the DNA polymerase I alpha-primase complex physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
POL12 YBL035C B subunit of DNA polymerase alpha-primase complex physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
PRI1 YIR008C Subunit of DNA primase physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
PRI2 YKL045W Subunit of DNA primase physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
STM1 YLR150W Protein required for optimal translation under nutrient stress genetic 2 1 2 Dosage Rescue, Dosage Rescue
TAF1 YGR274C TFIID subunit, involved in RNA pol II transcription initiation genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
ROM2 YLR371W Guanine nucleotide exchange factor (GEF) for Rho1p and Rho2p genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
BIM1 YER016W Microtubule plus end-tracking protein genetic 2 1 2 Synthetic Growth Defect, Synthetic Growth Defect
PKC1 YBL105C Protein serine/threonine kinase genetic 2 1 2 Dosage Rescue, Dosage Rescue
NOT5 YPR072W Component of the CCR4-NOT core complex, involved in mRNA decapping physical 2 1 2 Affinity Capture-Western, Affinity Capture-Western
MOT2 YER068W Ubiquitin-protein ligase subunit of the CCR4-NOT complex genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
LRG1 YDL240W GTPase-activating protein (GAP) genetic 2 1 2 Synthetic Rescue, Synthetic Rescue
ASF1 YJL115W Nucleosome assembly factor genetic 2 2 1 Synthetic Lethality, Synthetic Growth Defect
NOT3 YIL038C Component of the CCR4-NOT core complex, involved in mRNA decapping genetic 2 2 1 Synthetic Growth Defect, Synthetic Rescue
YAK1 YJL141C Serine-threonine protein kinase physical 2 2 1 Affinity Capture-Western, Biochemical Activity
TIS11 YLR136C mRNA-binding protein expressed during iron starvation physical 2 2 1 Two-hybrid, PCA
RAD51 YER095W Strand exchange protein genetic 2 2 1 Synthetic Growth Defect, Synthetic Lethality
RAD54 YGL163C DNA-dependent ATPase that stimulates strand exchange genetic 2 2 1 Synthetic Growth Defect, Synthetic Lethality
RTT101 YJL047C Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex genetic 2 2 1 Synthetic Growth Defect, Synthetic Lethality
RTT107 YHR154W BRCA1 C-terminal domain protein needed for recovery from DNA damage genetic 2 2 1 Synthetic Growth Defect, Synthetic Lethality
MOB1 YIL106W Component of the mitotic exit network physical 2 2 1 Affinity Capture-Western, Two-hybrid
PBP1 YGR178C Component of glucose deprivation induced stress granules genetic 2 2 1 Synthetic Rescue, Dosage Lethality
LRS4 YDR439W Nucleolar protein that forms a complex with Csm1p genetic 2 2 1 Synthetic Growth Defect, Synthetic Lethality
MRC1 YCL061C S-phase checkpoint protein required for DNA replication genetic 2 2 1 Synthetic Growth Defect, Phenotypic Enhancement
MMS1 YPR164W Subunit of E3 ubiquitin ligase complex involved in replication repair genetic 2 2 1 Synthetic Growth Defect, Synthetic Lethality
ESA1 YOR244W Catalytic subunit of the histone acetyltransferase complex (NuA4) genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
BRE1 YDL074C E3 ubiquitin ligase genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
ARD1 YHR013C Subunit of protein N-terminal acetyltransferase NatA genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
HDA1 YNL021W Catalytic subunit of class II HDA1 histone deacetylase complex genetic 2 1 1 Dosage Lethality, Dosage Lethality
CTF18 YMR078C Subunit of a complex with Ctf8p genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
EPL1 YFL024C Subunit of NuA4, an essential histone H4/H2A acetyltransferase complex genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
HAT2 YEL056W Subunit of the Hat1p-Hat2p histone acetyltransferase complex genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
HIS4 YCL030C Multifunctional enzyme containing phosphoribosyl-ATP pyrophosphatase genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
KGD1 YIL125W Subunit of the mitochondrial alpha-ketoglutarate dehydrogenase complex genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
LYS2 YBR115C Alpha aminoadipate reductase genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
YNG2 YHR090C Subunit of NuA4, an essential histone acetyltransferase complex genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
RAD55 YDR076W Protein that stimulates strand exchange genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
RAD18 YCR066W E3 ubiquitin ligase genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
RAD50 YNL250W Subunit of MRX complex with Mre11p and Xrs2p genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
RAD6 YGL058W Ubiquitin-conjugating enzyme (E2) genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
QCR9 YGR183C Subunit 9 of ubiquinol cytochrome-c reductase (Complex III) genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
SOD1 YJR104C Cytosolic copper-zinc superoxide dismutase genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
ADE3 YGR204W Cytoplasmic trifunctional enzyme genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
NAT1 YDL040C Subunit of protein N-terminal acetyltransferase NatA genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
MGA2 YIR033W ER membrane protein involved in regulation of OLE1 transcription genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
AAC3 YBR085W Mitochondrial inner membrane ADP/ATP translocator genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
GET1 YGL020C Subunit of the GET complex genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
DLD3 YEL071W 2-hydroxyglutarate transhydrogenase, and minor D-lactate dehydrogenase genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
DNL4 YOR005C DNA ligase required for nonhomologous end-joining (NHEJ) genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
CTF4 YPR135W Chromatin-associated protein genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
MRE11 YMR224C Nuclease subunit of the MRX complex with Rad50p and Xrs2p genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
MUS81 YDR386W Subunit of structure-specific Mms4p-Mus81p endonuclease genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
MMS22 YLR320W Subunit of E3 ubiquitin ligase complex involved in replication repair genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
HOF1 YMR032W F-BAR protein that regulates actin cytoskeleton organization genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
ASK10 YGR097W Regulator of the Fps1p glycerol channel genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
JLP1 YLL057C Fe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
AAD3 YCR107W Putative aryl-alcohol dehydrogenase genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
HMT1 YBR034C Nuclear SAM-dependent mono- and asymmetric methyltransferase physical 2 1 1 Affinity Capture-Western, Affinity Capture-Western
DCC1 YCL016C Subunit of a complex with Ctf8p and Ctf18p genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
ARG56 YER069W Acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
GRX4 YER174C Glutathione-dependent oxidoreductase and glutathione S-transferase genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
GRE3 YHR104W Aldose reductase genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
ETR1 YBR026C 2-enoyl thioester reductase genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
DOT5 YIL010W Nuclear thiol peroxidase genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
GUT2 YIL155C Mitochondrial glycerol-3-phosphate dehydrogenase genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
COA1 YIL157C Mitochondrial inner membrane protein genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
DFG10 YIL049W Probable polyprenol reductase genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
CRT10 YOL063C Protein required for the degradation of mutant 25S rRNAs genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
ORT1 YOR130C Ornithine transporter of the mitochondrial inner membrane genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
IXR1 YKL032C Transcriptional repressor that regulates hypoxic genes during normoxia regulation 1 1 1 DNA to cDNA expression microarray evidence
YAP6 YDR259C Basic leucine zipper (bZIP) transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
REB1 YBR049C RNA polymerase I enhancer binding protein regulation 1 1 1 chromatin immunoprecipitation-chip evidence
EAF1 YDR359C Component of the NuA4 histone acetyltransferase complex genetic 1 1 1 Synthetic Lethality
POP1 YNL221C Subunit of RNase MRP, nuclear RNase P and telomerase complexes physical 1 1 1 Affinity Capture-Western
LSM1 YJL124C Lsm (Like Sm) protein genetic 1 1 1 Synthetic Lethality
PAT1 YCR077C Deadenylation-dependent mRNA-decapping factor genetic 1 1 1 Synthetic Lethality
LSM6 YDR378C Lsm (Like Sm) protein genetic 1 1 1 Synthetic Lethality
DED1 YOR204W ATP-dependent DEAD-box RNA helicase with strand-annealing activity genetic 1 1 1 Synthetic Growth Defect
PAB1 YER165W Poly(A) binding protein physical 1 1 1 Biochemical Activity
CDC33 YOL139C Translation initiation factor eIF4E genetic 1 1 1 Dosage Rescue
NPL3 YDR432W RNA-binding protein genetic 1 1 1 Synthetic Growth Defect
MFT1 YML062C Subunit of the THO complex genetic 1 1 1 Synthetic Growth Defect
DST1 YGL043W General transcription elongation factor TFIIS physical 1 1 1 Reconstituted Complex
DST1 YGL043W General transcription elongation factor TFIIS genetic 1 1 1 Synthetic Growth Defect
ACT1 YFL039C Actin, structural protein in cytoskeleton genetic 1 1 1 Synthetic Haploinsufficiency
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-Western
ATP11 YNL315C Molecular chaperone genetic 1 1 1 Synthetic Growth Defect
BUD31 YCR063W Component of the SF3b subcomplex of the U2 snRNP genetic 1 1 1 Negative Genetic
CTK1 YKL139W Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I) genetic 1 1 1 Synthetic Lethality
DCP1 YOL149W Subunit of the Dcp1p-Dcp2p decapping enzyme complex physical 1 1 1 Affinity Capture-Western
DCP1 YOL149W Subunit of the Dcp1p-Dcp2p decapping enzyme complex genetic 1 1 1 Synthetic Lethality
HRP1 YOL123W Subunit of cleavage factor I physical 1 1 1 Affinity Capture-Western
END3 YNL084C EH domain-containing protein involved in endocytosis genetic 1 1 1 Synthetic Lethality
CRM1 YGR218W Nuclear export factor, exportin physical 1 1 1 Affinity Capture-MS
LSM7 YNL147W Lsm (Like Sm) protein genetic 1 1 1 Synthetic Lethality
MGM101 YJR144W Protein with a role in mitochondrial DNA recombinational repair genetic 1 1 1 Synthetic Growth Defect
CMR1 YDL156W Nuclear protein with role in transcription, protein quality control genetic 1 1 1 Negative Genetic
GIN4 YDR507C Protein kinase involved in bud growth and assembly of the septin ring genetic 1 1 1 Synthetic Growth Defect
NUP60 YAR002W FG-nucleoporin component of central core of the nuclear pore complex genetic 1 1 1 Synthetic Growth Defect
PIM1 YBL022C ATP-dependent Lon protease genetic 1 1 1 Synthetic Lethality
VMA1 YDL185W Subunit A of the V1 peripheral membrane domain of V-ATPase physical 1 1 1 Affinity Capture-MS
VMA1 YDL185W Subunit A of the V1 peripheral membrane domain of V-ATPase genetic 1 1 1 Synthetic Growth Defect
SSN2 YDR443C Subunit of the RNA polymerase II mediator complex physical 1 1 1 Two-hybrid
RTT106 YNL206C Histone chaperone physical 1 1 1 Reconstituted Complex
TCP1 YDR212W Alpha subunit of chaperonin-containing T-complex physical 1 1 1 Affinity Capture-MS
RIM1 YCR028C-A ssDNA-binding protein essential for mitochondrial genome maintenance physical 1 1 1 PCA
WHI3 YNL197C RNA binding protein that modulates mRNA stability physical 1 1 1 PCA
UBP3 YER151C Ubiquitin-specific protease that cleaves Ub-protein fusions physical 1 1 1 Affinity Capture-MS
SMY2 YBR172C GYF domain protein physical 1 1 1 Affinity Capture-MS
RPO21 YDL140C RNA polymerase II largest subunit B220 physical 1 1 1 Affinity Capture-Western
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
VAM6 YDL077C Guanine nucleotide exchange factor for the GTPase Gtr1p physical 1 1 1 Affinity Capture-MS
PUF3 YLL013C Protein of the mitochondrial outer surface physical 1 1 1 Affinity Capture-RNA
PUF2 YPR042C PUF family mRNA-binding protein physical 1 1 1 Affinity Capture-RNA
RPB4 YJL140W RNA polymerase II subunit B32 physical 1 1 1 Reconstituted Complex
RPB7 YDR404C RNA polymerase II subunit B16 physical 1 1 1 Reconstituted Complex
RPB3 YIL021W RNA polymerase II third largest subunit B44 physical 1 1 1 Affinity Capture-MS
STL1 YDR536W Glycerol proton symporter of the plasma membrane physical 1 1 1 Affinity Capture-RNA
RSP5 YER125W NEDD4 family E3 ubiquitin ligase physical 1 1 1 Reconstituted Complex
SRB4 YER022W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Synthetic Rescue
SPT6 YGR116W Nucleosome remodeling protein genetic 1 1 1 Synthetic Rescue
SPT3 YDR392W Subunit of the SAGA and SAGA-like transcriptional regulatory complexes genetic 1 1 1 Synthetic Rescue
SPT8 YLR055C Subunit of the SAGA transcriptional regulatory complex genetic 1 1 1 Synthetic Rescue
RAD7 YJR052W Nucleotide excision repair (NER) protein genetic 1 1 1 Synthetic Growth Defect
SWE1 YJL187C Protein kinase that regulates the G2/M transition genetic 1 1 1 Synthetic Rescue
SHS1 YDL225W Component of the septin ring that is required for cytokinesis genetic 1 1 1 Synthetic Growth Defect
TEF4 YKL081W Gamma subunit of translational elongation factor eEF1B genetic 1 1 1 Negative Genetic
SRL3 YKR091W Repressor of transcription at Start genetic 1 1 1 Negative Genetic
VPS9 YML097C Guanine nucleotide exchange factor (GEF) and ubiquitin receptor genetic 1 1 1 Negative Genetic
RAD27 YKL113C 5' to 3' exonuclease, 5' flap endonuclease genetic 1 1 1 Synthetic Growth Defect
SWC5 YBR231C Component of the SWR1 complex genetic 1 1 1 Synthetic Growth Defect
PTH1 YHR189W One of two mitochondrially-localized peptidyl-tRNA hydrolases genetic 1 1 1 Synthetic Growth Defect
RDH54 YBR073W DNA-dependent ATPase genetic 1 1 1 Synthetic Growth Defect
RMD8 YFR048W Cytosolic protein required for sporulation genetic 1 1 1 Synthetic Growth Defect
RPS29B YDL061C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Synthetic Growth Defect
RRM3 YHR031C DNA helicase involved in rDNA replication and Ty1 transposition genetic 1 1 1 Synthetic Growth Defect
SAP30 YMR263W Component of Rpd3L histone deacetylase complex genetic 1 1 1 Synthetic Growth Defect
SRO9 YCL037C Cytoplasmic RNA-binding protein genetic 1 1 1 Synthetic Growth Defect
SWR1 YDR334W Swi2/Snf2-related ATPase genetic 1 1 1 Synthetic Growth Defect
THP2 YHR167W Subunit of the THO and TREX complexes genetic 1 1 1 Synthetic Growth Defect
TOF2 YKR010C Protein required for rDNA silencing and mitotic rDNA condensation genetic 1 1 1 Synthetic Growth Defect
VAC14 YLR386W Enzyme regulator genetic 1 1 1 Synthetic Growth Defect
VID22 YLR373C G-quadruplex (G4) DNA binding protein genetic 1 1 1 Synthetic Growth Defect
VPS24 YKL041W One of four subunits of the ESCRT-III complex genetic 1 1 1 Synthetic Growth Defect
VPS30 YPL120W Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II genetic 1 1 1 Synthetic Growth Defect
SAE2 YGL175C Endonuclease required for telomere elongation genetic 1 1 1 Synthetic Growth Defect
SLX5 YDL013W Subunit of the Slx5-Slx8 SUMO-targeted Ub ligase (STUbL) complex genetic 1 1 1 Synthetic Lethality
SDS3 YIL084C Component of the Rpd3L histone deacetylase complex genetic 1 1 1 Synthetic Growth Defect
SOH1 YGL127C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Synthetic Growth Defect
STP22 YCL008C Component of the ESCRT-I complex genetic 1 1 1 Synthetic Growth Defect
SWI6 YLR182W Transcription cofactor genetic 1 1 1 Synthetic Growth Defect
VPS1 YKR001C Dynamin-like GTPase required for vacuolar sorting genetic 1 1 1 Synthetic Growth Defect
VPS4 YPR173C AAA-ATPase involved in multivesicular body (MVB) protein sorting genetic 1 1 1 Synthetic Growth Defect
VPS45 YGL095C Protein of the Sec1p/Munc-18 family genetic 1 1 1 Synthetic Growth Defect
YAF9 YNL107W Subunit of NuA4 histone H4 acetyltransferase and SWR1 complexes genetic 1 1 1 Synthetic Growth Defect
SLX8 YER116C Subunit of Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex genetic 1 1 1 Synthetic Growth Defect
RAD53 YPL153C DNA damage response kinase genetic 1 1 1 Synthetic Lethality
RCY1 YJL204C F-box protein involved in recycling endocytosed proteins genetic 1 1 1 Synthetic Lethality
RPA34 YJL148W RNA polymerase I subunit A34.5 genetic 1 1 1 Synthetic Lethality
RPD3 YNL330C Histone deacetylase, component of both the Rpd3S and Rpd3L complexes genetic 1 1 1 Synthetic Lethality
RVS161 YCR009C Amphiphysin-like lipid raft protein genetic 1 1 1 Synthetic Lethality
RVS167 YDR388W Calmodulin-binding actin-associated protein genetic 1 1 1 Synthetic Lethality
SAC1 YKL212W Phosphatidylinositol phosphate phosphatase genetic 1 1 1 Synthetic Lethality
VPS52 YDR484W Component of the GARP (Golgi-associated retrograde protein) complex genetic 1 1 1 Synthetic Lethality
SIC1 YLR079W Cyclin-dependent kinase inhibitor (CKI) genetic 1 1 1 Synthetic Lethality
SIN3 YOL004W Component of both the Rpd3S and Rpd3L histone deacetylase complexes genetic 1 1 1 Synthetic Lethality
SNF5 YBR289W Subunit of the SWI/SNF chromatin remodeling complex genetic 1 1 1 Synthetic Lethality
SNF8 YPL002C Component of the ESCRT-II complex genetic 1 1 1 Synthetic Lethality
SRB2 YHR041C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Synthetic Lethality
SST2 YLR452C GTPase-activating protein for Gpa1p genetic 1 1 1 Synthetic Lethality
STB5 YHR178W Transcription factor genetic 1 1 1 Synthetic Lethality
SWI4 YER111C DNA binding component of the SBF complex (Swi4p-Swi6p) genetic 1 1 1 Synthetic Lethality
VPS20 YMR077C Myristoylated subunit of the ESCRT-III complex genetic 1 1 1 Synthetic Lethality
VPS33 YLR396C ATP-binding protein that is a subunit of the HOPS and CORVET complexes genetic 1 1 1 Synthetic Lethality
VPS36 YLR417W Component of the ESCRT-II complex genetic 1 1 1 Synthetic Lethality
VPS53 YJL029C Component of the GARP (Golgi-associated retrograde protein) complex genetic 1 1 1 Synthetic Lethality
RRG1 YDR065W Protein of unknown function genetic 1 1 1 Synthetic Lethality
SNN1 YNL086W Subunit of the BLOC-1 complex involved in endosomal maturation genetic 1 1 1 Synthetic Lethality
VMA21 YGR105W Integral membrane protein required for V-ATPase function genetic 1 1 1 Synthetic Growth Defect
VOA1 YGR106C ER protein that functions in assembly of the V0 sector of V-ATPase genetic 1 1 1 Synthetic Growth Defect
TOP1 YOL006C Topoisomerase I genetic 1 1 1 Synthetic Growth Defect
RRP6 YOR001W Nuclear exosome exonuclease component genetic 1 1 1 Synthetic Growth Defect
TEL1 YBL088C Protein kinase primarily involved in telomere length regulation genetic 1 1 1 Synthetic Growth Defect
PSY2 YNL201C Subunit of protein phosphatase PP4 complex genetic 1 1 1 Negative Genetic
CSI1 YMR025W Subunit of the Cop9 signalosome physical 1 1 1 Two-hybrid
NUM1 YDR150W Protein required for nuclear migration genetic 1 1 1 Negative Genetic
PIL1 YGR086C Eisosome core component physical 1 1 1 Affinity Capture-MS
BRR1 YPR057W snRNP protein component of spliceosomal snRNPs genetic 1 1 1 Synthetic Growth Defect
MSL1 YIR009W U2B component of U2 snRNP genetic 1 1 1 Synthetic Lethality
ATG9 YDL149W Transmembrane protein involved in forming Cvt and autophagic vesicles genetic 1 1 1 Negative Genetic
HSE1 YHL002W Subunit of the endosomal Vps27p-Hse1p complex physical 1 1 1 Two-hybrid
BRO1 YPL084W Cytoplasmic class E vacuolar protein sorting (VPS) factor genetic 1 1 1 Synthetic Lethality
HEK2 YBL032W RNA binding protein involved in asymmetric localization of ASH1 mRNA physical 1 1 1 Affinity Capture-RNA
ATP4 YPL078C Subunit b of the stator stalk of mitochondrial F1F0 ATP synthase genetic 1 1 1 Synthetic Lethality
EGD2 YHR193C Alpha subunit of the nascent polypeptide-associated complex (NAC) physical 1 1 1 Affinity Capture-MS
ARF1 YDL192W ADP-ribosylation factor genetic 1 1 1 Synthetic Growth Defect
KOG1 YHR186C Subunit of TORC1 physical 1 1 1 Affinity Capture-MS
GET2 YER083C Subunit of the GET complex genetic 1 1 1 Synthetic Growth Defect
EGD1 YPL037C Subunit beta1 of the nascent polypeptide-associated complex (NAC) physical 1 1 1 Two-hybrid
MDM30 YLR368W F-box component of an SCF ubiquitin protein ligase complex genetic 1 1 1 Synthetic Growth Defect
GPD1 YDL022W NAD-dependent glycerol-3-phosphate dehydrogenase physical 1 1 1 Affinity Capture-RNA
GIP2 YER054C Putative regulatory subunit of protein phosphatase Glc7p genetic 1 1 1 Synthetic Lethality
ELM1 YKL048C Serine/threonine protein kinase genetic 1 1 1 Synthetic Growth Defect
POL30 YBR088C Proliferating cell nuclear antigen (PCNA) physical 1 1 1 Reconstituted Complex
POL30 YBR088C Proliferating cell nuclear antigen (PCNA) genetic 1 1 1 Phenotypic Enhancement
HIR1 YBL008W Subunit of the HIR complex genetic 1 1 1 Synthetic Growth Defect
CIN8 YEL061C Bipolar kinesin motor protein genetic 1 1 1 Synthetic Lethality
KIN2 YLR096W S/T protein kinase physical 1 1 1 Affinity Capture-MS
HIR2 YOR038C Subunit of HIR nucleosome assembly complex genetic 1 1 1 Synthetic Growth Defect
DIA2 YOR080W Origin-binding F-box protein genetic 1 1 1 Synthetic Lethality
CIK1 YMR198W Kinesin-associated protein genetic 1 1 1 Synthetic Lethality
CLB2 YPR119W B-type cyclin involved in cell cycle progression genetic 1 1 1 Dosage Lethality
EAP1 YKL204W eIF4E-associated protein, competes with eIF4G for binding to eIF4E genetic 1 1 1 Synthetic Lethality
MMS4 YBR098W Subunit of structure-specific Mms4p-Mus81p endonuclease genetic 1 1 1 Synthetic Growth Defect
ATP5 YDR298C Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase genetic 1 1 1 Synthetic Lethality
ATP7 YKL016C Subunit d of the stator stalk of mitochondrial F1F0 ATP synthase genetic 1 1 1 Synthetic Growth Defect
ARP1 YHR129C Actin-related protein of the dynactin complex genetic 1 1 1 Negative Genetic
DID4 YKL002W Class E Vps protein of the ESCRT-III complex genetic 1 1 1 Synthetic Growth Defect
MCM16 YPR046W Component of the Ctf19 complex and the COMA subcomplex physical 1 1 1 Two-hybrid
FOB1 YDR110W Nucleolar protein that binds the rDNA replication fork barrier site genetic 1 1 1 Phenotypic Suppression
NST1 YNL091W Translational inhibitor and suppressor of proteasome-assembly defects physical 1 1 1 PCA
ARP6 YLR085C Actin-related protein that binds nucleosomes genetic 1 1 1 Synthetic Growth Defect
ATG8 YBL078C Ub-like protein genetic 1 1 1 Negative Genetic
CTF8 YHR191C Subunit of a complex with Ctf18p genetic 1 1 1 Synthetic Growth Defect
BIK1 YCL029C Microtubule-associated protein genetic 1 1 1 Synthetic Growth Defect
PHO80 YOL001W Cyclin genetic 1 1 1 Negative Genetic
PEP7 YDR323C Adaptor protein involved in vesicle-mediated vacuolar protein sorting genetic 1 1 1 Synthetic Lethality
HMT1 YBR034C Nuclear SAM-dependent mono- and asymmetric methyltransferase genetic 1 1 1 Positive Genetic
ATP10 YLR393W Assembly factor for the F0 sector of mitochondrial F1F0 ATP synthase genetic 1 1 1 Synthetic Growth Defect
ATP1 YBL099W Alpha subunit of the F1 sector of mitochondrial F1F0 ATP synthase genetic 1 1 1 Synthetic Growth Defect
CLA4 YNL298W Cdc42p-activated signal transducing kinase genetic 1 1 1 Synthetic Growth Defect
AUR1 YKL004W Phosphatidylinositol:ceramide phosphoinositol transferase genetic 1 1 1 Negative Genetic
MON2 YNL297C Protein with a role in endocytosis and vacuole integrity genetic 1 1 1 Synthetic Lethality
MIT1 YEL007W Transcriptional regulator of pseudohyphal growth genetic 1 1 1 Synthetic Lethality
ATP17 YDR377W Subunit f of the F0 sector of mitochondrial F1F0 ATP synthase genetic 1 1 1 Synthetic Growth Defect
BTT1 YDR252W Heterotrimeric nascent polypeptide-associated complex beta3 subunit physical 1 1 1 Affinity Capture-Western
NPT1 YOR209C Nicotinate phosphoribosyltransferase genetic 1 1 1 Synthetic Growth Defect
LDB19 YOR322C Alpha-arrestin, Ub-ligase adaptor for Rsp5p genetic 1 1 1 Synthetic Growth Defect
IRC19 YLL033W Protein of unknown function genetic 1 1 1 Synthetic Growth Defect
GCS1 YDL226C ADP-ribosylation factor GTPase activating protein (ARF GAP) genetic 1 1 1 Synthetic Lethality
CTH1 YDR151C mRNA binding protein, member of the CCCH zinc finger family physical 1 1 1 Two-hybrid
LGE1 YPL055C Protein involved in histone H2B ubiquitination genetic 1 1 1 Synthetic Growth Defect
ERG3 YLR056W C-5 sterol desaturase genetic 1 1 1 Negative Genetic
CTT1 YGR088W Cytosolic catalase T physical 1 1 1 Two-hybrid
EMI1 YDR512C Non-essential protein of unknown function genetic 1 1 1 Synthetic Growth Defect
NHX1 YDR456W Na+/H+ and K+/H+ exchanger genetic 1 1 1 Synthetic Growth Defect
PIF1 YML061C DNA helicase, potent G-quadruplex DNA binder/unwinder genetic 1 1 1 Synthetic Growth Defect
ATP23 YNR020C Putative metalloprotease of the mitochondrial inner membrane genetic 1 1 1 Synthetic Growth Defect
MSY1 YPL097W Mitochondrial tyrosyl-tRNA synthetase genetic 1 1 1 Synthetic Lethality