| ELG1 |
YOR144C |
Subunit of an alternative replication factor C complex |
genetic |
16 |
5 |
12 |
Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Lethality, Negative Genetic, Phenotypic Suppression, Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| CDC13 |
YDL220C |
Single stranded DNA-binding protein found at TG1-3 telomere G-tails |
genetic |
15 |
5 |
12 |
Synthetic Rescue, Phenotypic Suppression, Synthetic Rescue, Synthetic Growth Defect, Phenotypic Suppression, Phenotypic Enhancement, Synthetic Rescue, Synthetic Growth Defect, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Positive Genetic, Synthetic Rescue, Synthetic Rescue |
| RAD27 |
YKL113C |
5' to 3' exonuclease, 5' flap endonuclease |
genetic |
13 |
4 |
10 |
Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Phenotypic Suppression, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic |
| POL32 |
YJR043C |
Third subunit of DNA polymerase delta |
genetic |
11 |
4 |
7 |
Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Suppression, Synthetic Rescue, Negative Genetic, Negative Genetic |
| MRC1 |
YCL061C |
S-phase checkpoint protein required for DNA replication |
genetic |
11 |
4 |
7 |
Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Phenotypic Enhancement, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Lethality, Negative Genetic, Negative Genetic |
| SGS1 |
YMR190C |
RecQ family nucleolar DNA helicase |
genetic |
10 |
3 |
9 |
Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Rescue, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Rescue, Phenotypic Suppression |
| RAD5 |
YLR032W |
DNA helicase/Ubiquitin ligase |
genetic |
10 |
3 |
7 |
Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Dosage Lethality |
| CTF18 |
YMR078C |
Subunit of a complex with Ctf8p |
genetic |
9 |
4 |
7 |
Synthetic Lethality, Synthetic Lethality, Phenotypic Enhancement, Synthetic Growth Defect, Negative Genetic, Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement |
| DIA2 |
YOR080W |
Origin-binding F-box protein |
genetic |
9 |
2 |
6 |
Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic |
| CSM3 |
YMR048W |
Replication fork associated factor |
genetic |
9 |
2 |
6 |
Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic |
| RAD9 |
YDR217C |
DNA damage-dependent checkpoint protein |
genetic |
8 |
4 |
8 |
Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Suppression, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Rescue |
| RFC5 |
YBR087W |
Subunit of heteropentameric Replication factor C (RF-C) |
physical |
8 |
5 |
6 |
Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Co-purification, Co-fractionation, Co-purification |
| POL3 |
YDL102W |
Catalytic subunit of DNA polymerase delta |
genetic |
8 |
5 |
6 |
Synthetic Lethality, Dosage Lethality, Negative Genetic, Synthetic Lethality, Phenotypic Suppression, Synthetic Growth Defect, Negative Genetic, Negative Genetic |
| RFC3 |
YNL290W |
Subunit of heteropentameric Replication factor C (RF-C) |
physical |
8 |
4 |
6 |
Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex, Co-purification, Co-purification |
| RFC2 |
YJR068W |
Subunit of heteropentameric Replication factor C (RF-C) |
physical |
8 |
4 |
6 |
Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex, Co-purification, Co-purification |
| TOF1 |
YNL273W |
Subunit of a replication-pausing checkpoint complex |
genetic |
8 |
3 |
6 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Lethality, Negative Genetic, Negative Genetic |
| DUN1 |
YDL101C |
Cell-cycle checkpoint S/T protein kinase |
genetic |
7 |
2 |
6 |
Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic |
| DCC1 |
YCL016C |
Subunit of a complex with Ctf8p and Ctf18p |
genetic |
6 |
3 |
5 |
Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Phenotypic Enhancement |
| RFC4 |
YOL094C |
Subunit of heteropentameric Replication factor C (RF-C) |
physical |
5 |
3 |
4 |
Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Co-purification, Co-purification |
| SIC1 |
YLR079W |
Cyclin-dependent kinase inhibitor (CKI) |
genetic |
5 |
2 |
4 |
Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| CDC7 |
YDL017W |
S/T kinase and catalytic subunit of DDK (Dbf4-dependent kinase) |
genetic |
5 |
2 |
4 |
Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic |
| RAD53 |
YPL153C |
DNA damage response kinase |
genetic |
4 |
4 |
4 |
Phenotypic Enhancement, Negative Genetic, Synthetic Rescue, Phenotypic Suppression |
| POL2 |
YNL262W |
Catalytic subunit of DNA polymerase (II) epsilon |
genetic |
4 |
3 |
4 |
Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Phenotypic Enhancement |
| STN1 |
YDR082W |
Telomere end-binding and capping protein |
genetic |
4 |
3 |
4 |
Synthetic Lethality, Synthetic Rescue, Negative Genetic, Synthetic Rescue |
| TEL1 |
YBL088C |
Protein kinase primarily involved in telomere length regulation |
genetic |
4 |
3 |
4 |
Phenotypic Suppression, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect |
| DPB11 |
YJL090C |
DNA replication initiation protein |
genetic |
4 |
3 |
4 |
Phenotypic Enhancement, Negative Genetic, Synthetic Growth Defect, Negative Genetic |
| RAD18 |
YCR066W |
E3 ubiquitin ligase |
genetic |
4 |
2 |
4 |
Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect, Negative Genetic |
| CDC6 |
YJL194W |
Essential ATP-binding protein required for DNA replication |
genetic |
4 |
2 |
3 |
Dosage Lethality, Negative Genetic, Negative Genetic, Negative Genetic |
| TSA1 |
YML028W |
Thioredoxin peroxidase |
genetic |
4 |
2 |
3 |
Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect |
| CTF8 |
YHR191C |
Subunit of a complex with Ctf18p |
genetic |
4 |
2 |
3 |
Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic |
| CDC8 |
YJR057W |
Nucleoside monophosphate and nucleoside diphosphate kinase |
genetic |
4 |
2 |
3 |
Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic |
| POL1 |
YNL102W |
Catalytic subunit of the DNA polymerase I alpha-primase complex |
genetic |
3 |
3 |
3 |
Dosage Lethality, Synthetic Growth Defect, Negative Genetic |
| CDC9 |
YDL164C |
DNA ligase I found in nucleus and mitochondria |
genetic |
3 |
3 |
3 |
Dosage Lethality, Negative Genetic, Phenotypic Suppression |
| RFC1 |
YOR217W |
Subunit of heteropentameric Replication factor C (RF-C) |
genetic |
3 |
3 |
3 |
Dosage Lethality, Phenotypic Enhancement, Negative Genetic |
| RAD51 |
YER095W |
Strand exchange protein |
genetic |
3 |
3 |
3 |
Dosage Rescue, Synthetic Lethality, Phenotypic Suppression |
| RTT107 |
YHR154W |
BRCA1 C-terminal domain protein needed for recovery from DNA damage |
genetic |
3 |
3 |
3 |
Phenotypic Enhancement, Phenotypic Suppression, Negative Genetic |
| ORC2 |
YBR060C |
Subunit of the origin recognition complex (ORC) |
genetic |
3 |
2 |
3 |
Synthetic Lethality, Negative Genetic, Negative Genetic |
| REV3 |
YPL167C |
Catalytic subunit of DNA polymerase zeta |
genetic |
3 |
2 |
3 |
Synthetic Growth Defect, Phenotypic Suppression, Phenotypic Suppression |
| RTT109 |
YLL002W |
Histone acetyltransferase |
genetic |
3 |
2 |
3 |
Negative Genetic, Phenotypic Suppression, Negative Genetic |
| ARP8 |
YOR141C |
Nuclear actin-related protein involved in chromatin remodeling |
genetic |
3 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic |
| MMS21 |
YEL019C |
Highly conserved SUMO E3 ligase subunit of SMC5-SMC6 complex |
genetic |
3 |
3 |
2 |
Synthetic Growth Defect, Phenotypic Suppression, Phenotypic Enhancement |
| RAD6 |
YGL058W |
Ubiquitin-conjugating enzyme (E2) |
genetic |
3 |
2 |
2 |
Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect |
| DBF4 |
YDR052C |
Regulatory subunit of Cdc7p-Dbf4p kinase complex |
genetic |
3 |
2 |
2 |
Synthetic Growth Defect, Negative Genetic, Negative Genetic |
| POL31 |
YJR006W |
Subunit of DNA polymerase delta (polymerase III) |
genetic |
3 |
2 |
2 |
Synthetic Growth Defect, Negative Genetic, Negative Genetic |
| PSF1 |
YDR013W |
Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| POL12 |
YBL035C |
B subunit of DNA polymerase alpha-primase complex |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| MCM2 |
YBL023C |
Protein involved in DNA replication |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| ORC3 |
YLL004W |
Subunit of the origin recognition complex (ORC) |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| ASF1 |
YJL115W |
Nucleosome assembly factor |
genetic |
2 |
2 |
2 |
Phenotypic Enhancement, Synthetic Rescue |
| CDC45 |
YLR103C |
DNA replication initiation factor |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Negative Genetic |
| DOA1 |
YKL213C |
WD-repeat protein involved in ubiquitin-mediated protein degradation |
genetic |
2 |
2 |
2 |
Phenotypic Enhancement, Synthetic Growth Defect |
| NHP10 |
YDL002C |
Non-essential INO80 chromatin remodeling complex subunit |
genetic |
2 |
2 |
2 |
Phenotypic Suppression, Negative Genetic |
| DDC1 |
YPL194W |
DNA damage checkpoint protein |
physical |
2 |
2 |
2 |
Two-hybrid, Co-localization |
| RLF2 |
YPR018W |
Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1) |
genetic |
2 |
2 |
2 |
Phenotypic Enhancement, Negative Genetic |
| TOP3 |
YLR234W |
DNA Topoisomerase III |
genetic |
2 |
2 |
2 |
Phenotypic Enhancement, Synthetic Growth Defect |
| SOD1 |
YJR104C |
Cytosolic copper-zinc superoxide dismutase |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Synthetic Lethality |
| TOP1 |
YOL006C |
Topoisomerase I |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Negative Genetic |
| APN1 |
YKL114C |
Major apurinic/apyrimidinic endonuclease |
genetic |
2 |
2 |
2 |
Phenotypic Enhancement, Synthetic Rescue |
| EST2 |
YLR318W |
Reverse transcriptase subunit of the telomerase holoenzyme |
genetic |
2 |
2 |
2 |
Phenotypic Enhancement, Synthetic Rescue |
| LSM1 |
YJL124C |
Lsm (Like Sm) protein |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| PMA1 |
YGL008C |
Plasma membrane P2-type H+-ATPase |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| POL30 |
YBR088C |
Proliferating cell nuclear antigen (PCNA) |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| RFA1 |
YAR007C |
Subunit of heterotrimeric Replication Protein A (RPA) |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| HST3 |
YOR025W |
Sirtuin, histone H3 deacetylase |
genetic |
2 |
1 |
2 |
Synthetic Rescue, Synthetic Rescue |
| HST4 |
YDR191W |
NAD(+)-dependent protein deacetylase |
genetic |
2 |
1 |
2 |
Synthetic Rescue, Synthetic Rescue |
| HPR1 |
YDR138W |
Subunit of THO/TREX complexes |
genetic |
2 |
2 |
1 |
Synthetic Lethality, Synthetic Growth Defect |
| DUN1 |
YDL101C |
Cell-cycle checkpoint S/T protein kinase |
physical |
2 |
2 |
1 |
Affinity Capture-MS, Affinity Capture-Western |
| CDC9 |
YDL164C |
DNA ligase I found in nucleus and mitochondria |
physical |
2 |
2 |
1 |
Reconstituted Complex, Biochemical Activity |
| EXO1 |
YOR033C |
5'-3' exonuclease and flap-endonuclease |
genetic |
2 |
2 |
1 |
Synthetic Rescue, Phenotypic Suppression |
| PSF2 |
YJL072C |
Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| MCM5 |
YLR274W |
Component of the Mcm2-7 hexameric helicase complex |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| RFC4 |
YOL094C |
Subunit of heteropentameric Replication factor C (RF-C) |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| SPO11 |
YHL022C |
Meiosis-specific protein required for meiotic recombination |
genetic |
2 |
1 |
1 |
Phenotypic Suppression, Phenotypic Suppression |
| SLD5 |
YDR489W |
Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| SLD3 |
YGL113W |
Protein involved in the initiation of DNA replication |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| MCM7 |
YBR202W |
Component of the Mcm2-7 hexameric helicase complex |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| ORC6 |
YHR118C |
Subunit of the origin recognition complex (ORC) |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| ORC4 |
YPR162C |
Subunit of the origin recognition complex (ORC) |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| SFP1 |
YLR403W |
Regulates transcription of ribosomal protein and biogenesis genes |
regulation |
1 |
1 |
1 |
DNA to cDNA expression microarray evidence |
| CDC73 |
YLR418C |
Component of the Paf1p complex |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| LEO1 |
YOR123C |
Component of the Paf1 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| BRE1 |
YDL074C |
E3 ubiquitin ligase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CDC42 |
YLR229C |
Small rho-like GTPase |
genetic |
1 |
1 |
1 |
Positive Genetic |
| PAT1 |
YCR077C |
Deadenylation-dependent mRNA-decapping factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| LSM6 |
YDR378C |
Lsm (Like Sm) protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PSY2 |
YNL201C |
Subunit of protein phosphatase PP4 complex |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| CBC2 |
YPL178W |
Small subunit of the heterodimeric cap binding complex with Sto1p |
physical |
1 |
1 |
1 |
Two-hybrid |
| CCR4 |
YAL021C |
Component of the CCR4-NOT transcriptional complex |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| CCR4 |
YAL021C |
Component of the CCR4-NOT transcriptional complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| APC1 |
YNL172W |
Largest subunit of the Anaphase-Promoting Complex/Cyclosome |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CDC11 |
YJR076C |
Component of the septin ring that is required for cytokinesis |
genetic |
1 |
1 |
1 |
Positive Genetic |
| COX6 |
YHR051W |
Subunit VI of cytochrome c oxidase (Complex IV) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| HHF1 |
YBR009C |
Histone H4 |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| ISW1 |
YBR245C |
ATPase subunit of imitation-switch (ISWI) class chromatin remodelers |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| ISW2 |
YOR304W |
ATP-dependent DNA translocase involved in chromatin remodeling |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| MCM6 |
YGL201C |
Protein involved in DNA replication |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MEC1 |
YBR136W |
Genome integrity checkpoint protein and PI kinase superfamily member |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MPH1 |
YIR002C |
3'-5' DNA helicase involved in error-free bypass of DNA lesions |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| HTZ1 |
YOL012C |
Histone variant H2AZ |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| AHA1 |
YDR214W |
Co-chaperone that binds Hsp82p and activates its ATPase activity |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| NUP116 |
YMR047C |
FG-nucleoporin component of central core of the nuclear pore complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NUP60 |
YAR002W |
FG-nucleoporin component of central core of the nuclear pore complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| ORC1 |
YML065W |
Largest subunit of the origin recognition complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PPH3 |
YDR075W |
Catalytic subunit of protein phosphatase PP4 complex |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| HTA1 |
YDR225W |
Histone H2A |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| LIN1 |
YHR156C |
Non-essential component of U5 snRNP |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NRD1 |
YNL251C |
RNA-binding subunit of Nrd1 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| HTA2 |
YBL003C |
Histone H2A |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| MET18 |
YIL128W |
Component of cytosolic iron-sulfur protein assembly (CIA) machinery |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NUP84 |
YDL116W |
Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| FUN30 |
YAL019W |
Snf2p family member with ATP-dependent chromatin remodeling activity |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| RAD1 |
YPL022W |
Single-stranded DNA endonuclease (with Rad10p) |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| CHK1 |
YBR274W |
Serine/threonine kinase and DNA damage checkpoint effector |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| DDC1 |
YPL194W |
DNA damage checkpoint protein |
genetic |
1 |
1 |
1 |
Dosage Rescue |
| DMC1 |
YER179W |
Meiosis-specific recombinase required for double-strand break repair |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| ILV3 |
YJR016C |
Dihydroxyacid dehydratase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CCT3 |
YJL014W |
Subunit of the cytosolic chaperonin Cct ring complex |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| PDS1 |
YDR113C |
Securin |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| CDC4 |
YFL009W |
F-box protein required for both the G1/S and G2/M phase transitions |
genetic |
1 |
1 |
1 |
Dosage Lethality |
| NPA3 |
YJR072C |
Member of the conserved GPN-loop GTPase family |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| CDC15 |
YAR019C |
Hippo-like kinase of the Mitotic Exit Network |
genetic |
1 |
1 |
1 |
Dosage Lethality |
| RFC5 |
YBR087W |
Subunit of heteropentameric Replication factor C (RF-C) |
genetic |
1 |
1 |
1 |
Dosage Rescue |
| RPT3 |
YDR394W |
ATPase of the 19S regulatory particle of the 26S proteasome |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| TCP1 |
YDR212W |
Alpha subunit of chaperonin-containing T-complex |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| RAD24 |
YER173W |
Checkpoint protein |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
| RFC1 |
YOR217W |
Subunit of heteropentameric Replication factor C (RF-C) |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
| SAE3 |
YHR079C-A |
Meiosis-specific protein involved in meiotic recombination |
physical |
1 |
1 |
1 |
Two-hybrid |
| RAD57 |
YDR004W |
Protein that stimulates strand exchange |
physical |
1 |
1 |
1 |
Two-hybrid |
| RAD57 |
YDR004W |
Protein that stimulates strand exchange |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| REV7 |
YIL139C |
Accessory subunit of DNA polymerase zeta |
physical |
1 |
1 |
1 |
Two-hybrid |
| RFA1 |
YAR007C |
Subunit of heterotrimeric Replication Protein A (RPA) |
physical |
1 |
1 |
1 |
Two-hybrid |
| VTS1 |
YOR359W |
Flap-structured DNA-binding and RNA-binding protein |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| RCK1 |
YGL158W |
Protein kinase involved in oxidative stress response |
genetic |
1 |
1 |
1 |
Dosage Lethality |
| RCK2 |
YLR248W |
Protein kinase involved in response to oxidative and osmotic stress |
genetic |
1 |
1 |
1 |
Dosage Lethality |
| RAD54 |
YGL163C |
DNA-dependent ATPase that stimulates strand exchange |
genetic |
1 |
1 |
1 |
Dosage Rescue |
| SET1 |
YHR119W |
Histone methyltransferase, subunit of the COMPASS (Set1C) complex |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| RAD3 |
YER171W |
5' to 3' DNA helicase |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| SAC3 |
YDR159W |
mRNA export factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SIN3 |
YOL004W |
Component of both the Rpd3S and Rpd3L histone deacetylase complexes |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SLX8 |
YER116C |
Subunit of Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| UME6 |
YDR207C |
Rpd3L histone deacetylase complex subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RIM1 |
YCR028C-A |
ssDNA-binding protein essential for mitochondrial genome maintenance |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SRB2 |
YHR041C |
Subunit of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SSN8 |
YNL025C |
Cyclin-like component of RNA polymerase II holoenzyme |
genetic |
1 |
1 |
1 |
Positive Genetic |
| RTT101 |
YJL047C |
Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| RRM3 |
YHR031C |
DNA helicase involved in rDNA replication and Ty1 transposition |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| RAD55 |
YDR076W |
Protein that stimulates strand exchange |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| RAD50 |
YNL250W |
Subunit of MRX complex with Mre11p and Xrs2p |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| RAD52 |
YML032C |
Protein involved in homologous recombination |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| SRS2 |
YJL092W |
DNA helicase and DNA-dependent ATPase |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| WSS1 |
YHR134W |
SUMO-ligase and SUMO-targeted metalloprotease |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| RPP1A |
YDL081C |
Ribosomal stalk protein P1 alpha |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SWI4 |
YER111C |
DNA binding component of the SBF complex (Swi4p-Swi6p) |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| YKU70 |
YMR284W |
Subunit of the telomeric Ku complex (Yku70p-Yku80p) |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| RNR4 |
YGR180C |
Ribonucleotide-diphosphate reductase (RNR) small subunit |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| SMC6 |
YLR383W |
Subunit of the SMC5-SMC6 complex |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| RMI1 |
YPL024W |
Subunit of the RecQ (Sgs1p) - Topo III (Top3p) complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| STM1 |
YLR150W |
Protein required for optimal translation under nutrient stress |
genetic |
1 |
1 |
1 |
Dosage Rescue |
| ZIM17 |
YNL310C |
Protein co-chaperone with a zinc finger motif |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| RIF1 |
YBR275C |
Protein involved in control of DNA replication |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| TEN1 |
YLR010C |
Protein that regulates telomeric length |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| RUB1 |
YDR139C |
Ubiquitin-like protein with similarity to mammalian NEDD8 |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| TPP1 |
YMR156C |
DNA 3'-phosphatase |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| VHS1 |
YDR247W |
Cytoplasmic serine/threonine protein kinase |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
| SLX4 |
YLR135W |
Endonuclease involved in processing DNA |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RTT106 |
YNL206C |
Histone chaperone |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| SAD1 |
YFR005C |
Conserved zinc-finger domain protein involved in pre-mRNA splicing |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RFA2 |
YNL312W |
Subunit of heterotrimeric Replication Protein A (RPA) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPB11 |
YOL005C |
RNA polymerase II subunit B12.5 |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TAH11 |
YJR046W |
DNA replication licensing factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SPH1 |
YLR313C |
Protein involved in shmoo formation and bipolar bud site selection |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SMA2 |
YML066C |
Meiosis-specific prospore membrane protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ZWF1 |
YNL241C |
Glucose-6-phosphate dehydrogenase (G6PD) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SUV3 |
YPL029W |
ATP-dependent RNA helicase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YKU80 |
YMR106C |
Subunit of telomeric Ku complex (Yku70p-Yku80p) |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| SCH9 |
YHR205W |
AGC family protein kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SPE2 |
YOL052C |
S-adenosylmethionine decarboxylase |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SPE1 |
YKL184W |
Ornithine decarboxylase |
genetic |
1 |
1 |
1 |
Positive Genetic |
| USO1 |
YDL058W |
Essential protein involved in vesicle-mediated ER to Golgi transport |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TRS85 |
YDR108W |
Component of transport protein particle (TRAPP) complex III |
genetic |
1 |
1 |
1 |
Negative Genetic |
| INA1 |
YLR413W |
Protein of unknown function |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| HOG1 |
YLR113W |
Mitogen-activated protein kinase involved in osmoregulation |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| HHT1 |
YBR010W |
Histone H3 |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| CTF4 |
YPR135W |
Chromatin-associated protein |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| MRE11 |
YMR224C |
Nuclease subunit of the MRX complex with Rad50p and Xrs2p |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| RAD14 |
YMR201C |
Subunit of Nucleotide Excision Repair Factor 1 (NEF1) |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| BUB3 |
YOR026W |
Kinetochore checkpoint WD40 repeat protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| FUS3 |
YBL016W |
Mitogen-activated serine/threonine protein kinase involved in mating |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MEC3 |
YLR288C |
DNA damage and meiotic pachytene checkpoint protein |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
| BIR1 |
YJR089W |
Subunit of chromosomal passenger complex (CPC) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NUP133 |
YKR082W |
Subunit of Nup84p subcomplex of nuclear pore complex (NPC) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PML1 |
YLR016C |
Subunit of the RES complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MCM10 |
YIL150C |
Essential chromatin-associated protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MAD2 |
YJL030W |
Component of the spindle-assembly checkpoint complex |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| MSH5 |
YDL154W |
Protein of the MutS family |
physical |
1 |
1 |
1 |
Two-hybrid |
| ISY1 |
YJR050W |
Member of the NineTeen Complex (NTC) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| BUB1 |
YGR188C |
Protein kinase involved in the cell cycle checkpoint into anaphase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CLB5 |
YPR120C |
B-type cyclin involved in DNA replication during S phase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| DCD1 |
YHR144C |
Deoxycytidine monophosphate (dCMP) deaminase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| GIM4 |
YEL003W |
Subunit of the heterohexameric cochaperone prefoldin complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ECO1 |
YFR027W |
Acetyltransferase required for sister chromatid cohesion |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
| ECO1 |
YFR027W |
Acetyltransferase required for sister chromatid cohesion |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| DOT1 |
YDR440W |
Nucleosomal histone H3-Lys79 methylase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| PRI1 |
YIR008C |
Subunit of DNA primase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| APN2 |
YBL019W |
Class II abasic (AP) endonuclease involved in repair of DNA damage |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| MIP1 |
YOR330C |
Mitochondrial DNA polymerase gamma |
genetic |
1 |
1 |
1 |
Positive Genetic |
| PIN3 |
YPR154W |
Negative regulator of actin nucleation-promoting factor activity |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MRC1 |
YCL061C |
S-phase checkpoint protein required for DNA replication |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
| MMS1 |
YPR164W |
Subunit of E3 ubiquitin ligase complex involved in replication repair |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| PSY3 |
YLR376C |
Component of Shu complex (aka PCSS complex) |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| HRQ1 |
YDR291W |
3'-5' DNA helicase of the conserved RecQ family |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DDR48 |
YMR173W |
DNA damage-responsive protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| AIM23 |
YJL131C |
Mitochondrial translation initiation factor 3 (IF3, mIF3) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PRI2 |
YKL045W |
Subunit of DNA primase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| KIN82 |
YCR091W |
Putative serine/threonine protein kinase |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
| MET7 |
YOR241W |
Folylpolyglutamate synthetase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MPS3 |
YJL019W |
Nuclear envelope protein |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| LGE1 |
YPL055C |
Protein involved in histone H2B ubiquitination |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| DFR1 |
YOR236W |
Dihydrofolate reductase involved in tetrahydrofolate biosynthesis |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PIF1 |
YML061C |
DNA helicase, potent G-quadruplex DNA binder/unwinder |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
