| RNH201 |
YNL072W |
Ribonuclease H2 catalytic subunit |
genetic |
13 |
3 |
11 |
Synthetic Lethality, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Lethality, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Lethality, Phenotypic Enhancement, Synthetic Lethality, Synthetic Growth Defect, Phenotypic Enhancement |
| HPR1 |
YDR138W |
Subunit of THO/TREX complexes |
genetic |
6 |
2 |
6 |
Phenotypic Suppression, Synthetic Rescue, Phenotypic Suppression, Phenotypic Suppression, Phenotypic Suppression, Phenotypic Suppression |
| NPL3 |
YDR432W |
RNA-binding protein |
genetic |
3 |
2 |
3 |
Phenotypic Suppression, Phenotypic Suppression, Synthetic Rescue |
| POL2 |
YNL262W |
Catalytic subunit of DNA polymerase (II) epsilon |
genetic |
3 |
2 |
3 |
Synthetic Lethality, Synthetic Lethality, Dosage Rescue |
| RAD30 |
YDR419W |
DNA polymerase eta |
genetic |
3 |
2 |
2 |
Synthetic Lethality, Synthetic Rescue, Synthetic Rescue |
| RAD52 |
YML032C |
Protein involved in homologous recombination |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Phenotypic Suppression |
| SPT2 |
YER161C |
Protein involved in negative regulation of transcription |
genetic |
2 |
2 |
2 |
Dosage Rescue, Phenotypic Suppression |
| SAP30 |
YMR263W |
Component of Rpd3L histone deacetylase complex |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| RRM3 |
YHR031C |
DNA helicase involved in rDNA replication and Ty1 transposition |
genetic |
2 |
1 |
2 |
Phenotypic Enhancement, Phenotypic Enhancement |
| PET127 |
YOR017W |
Protein with a role in 5'-end processing of mitochondrial RNAs |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| SIN3 |
YOL004W |
Component of both the Rpd3S and Rpd3L histone deacetylase complexes |
genetic |
2 |
2 |
1 |
Phenotypic Suppression, Phenotypic Enhancement |
| SSN2 |
YDR443C |
Subunit of the RNA polymerase II mediator complex |
genetic |
2 |
2 |
1 |
Phenotypic Enhancement, Phenotypic Suppression |
| BUR2 |
YLR226W |
Cyclin for the Sgv1p (Bur1p) protein kinase |
genetic |
2 |
2 |
1 |
Phenotypic Enhancement, Phenotypic Suppression |
| FKH1 |
YIL131C |
Forkhead family transcription factor |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| FKH2 |
YNL068C |
Forkhead family transcription factor |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| MED4 |
YOR174W |
Subunit of the RNA polymerase II mediator complex |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| RPD3 |
YNL330C |
Histone deacetylase, component of both the Rpd3S and Rpd3L complexes |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| CDC73 |
YLR418C |
Component of the Paf1p complex |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| CWC25 |
YNL245C |
Splicing factor required for the first step of pre-mRNA splicing |
genetic |
1 |
1 |
1 |
Negative Genetic |
| LEO1 |
YOR123C |
Component of the Paf1 complex |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| POB3 |
YML069W |
Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| RLP7 |
YNL002C |
Nucleolar protein similar to large ribosomal subunit L7 proteins |
genetic |
1 |
1 |
1 |
Negative Genetic |
| POP1 |
YNL221C |
Subunit of RNase MRP, nuclear RNase P and telomerase complexes |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NUT1 |
YGL151W |
Component of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| REI1 |
YBR267W |
Cytoplasmic pre-60S factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PRE8 |
YML092C |
Alpha 2 subunit of the 20S proteasome |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CCR4 |
YAL021C |
Component of the CCR4-NOT transcriptional complex |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| ATP11 |
YNL315C |
Molecular chaperone |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DPB2 |
YPR175W |
Second largest subunit of DNA polymerase II (DNA polymerase epsilon) |
genetic |
1 |
1 |
1 |
Dosage Rescue |
| ERG13 |
YML126C |
3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DHH1 |
YDL160C |
Cytoplasmic DEAD-box helicase and mRNA decapping activator |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| CRM1 |
YGR218W |
Nuclear export factor, exportin |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| MAK3 |
YPR051W |
Catalytic subunit of the NatC type N-terminal acetyltransferase (NAT) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MED1 |
YPR070W |
Subunit of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| COG3 |
YER157W |
Essential component of the conserved oligomeric Golgi complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MLH1 |
YMR167W |
Protein required for mismatch repair in mitosis and meiosis |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| MPH1 |
YIR002C |
3'-5' DNA helicase involved in error-free bypass of DNA lesions |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| CMR1 |
YDL156W |
Nuclear protein with role in transcription, protein quality control |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| POL1 |
YNL102W |
Catalytic subunit of the DNA polymerase I alpha-primase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| HSP82 |
YPL240C |
Hsp90 chaperone |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| PRP6 |
YBR055C |
Splicing factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RAD3 |
YER171W |
5' to 3' DNA helicase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| RAD51 |
YER095W |
Strand exchange protein |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| RFA1 |
YAR007C |
Subunit of heterotrimeric Replication Protein A (RPA) |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| RFA3 |
YJL173C |
Subunit of heterotrimeric Replication Protein A (RPA) |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| VAS1 |
YGR094W |
Mitochondrial and cytoplasmic valyl-tRNA synthetase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| TOP1 |
YOL006C |
Topoisomerase I |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| SDS3 |
YIL084C |
Component of the Rpd3L histone deacetylase complex |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| STB3 |
YDR169C |
Ribosomal RNA processing element (RRPE)-binding protein |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| SSN3 |
YPL042C |
Component of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| SRB8 |
YCR081W |
Subunit of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| SSN8 |
YNL025C |
Cyclin-like component of RNA polymerase II holoenzyme |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| SIN4 |
YNL236W |
Subunit of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| XRN1 |
YGL173C |
Evolutionarily-conserved 5'-3' exonuclease |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| RRP6 |
YOR001W |
Nuclear exosome exonuclease component |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| RNH202 |
YDR279W |
Ribonuclease H2 subunit |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| RNH203 |
YLR154C |
Ribonuclease H2 subunit |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| SPT3 |
YDR392W |
Subunit of the SAGA and SAGA-like transcriptional regulatory complexes |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| SPT16 |
YGL207W |
Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| RPT4 |
YOR259C |
ATPase of the 19S regulatory particle of the 26S proteasome |
genetic |
1 |
1 |
1 |
Positive Genetic |
| YCR090C |
YCR090C |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Positive Genetic |
| RPG1 |
YBR079C |
eIF3a subunit of the eukaryotic translation initiation factor 3 (eIF3) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TAF13 |
YML098W |
TFIID subunit (19 kDa) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YGL185C |
YGL185C |
Putative protein with sequence similar to hydroxyacid dehydrogenases |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPL19B |
YBL027W |
Ribosomal 60S subunit protein L19B |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YCR102C |
YCR102C |
Putative quinone oxidoreductase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| VAM7 |
YGL212W |
Vacuolar SNARE protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RTF1 |
YGL244W |
Subunit of RNAPII-associated chromatin remodeling Paf1 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YJR120W |
YJR120W |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SIC1 |
YLR079W |
Cyclin-dependent kinase inhibitor (CKI) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TGS1 |
YPL157W |
Trimethyl guanosine synthase, conserved nucleolar methyl transferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ZWF1 |
YNL241C |
Glucose-6-phosphate dehydrogenase (G6PD) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TOM6 |
YOR045W |
Component of the TOM (translocase of outer membrane) complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TOP2 |
YNL088W |
Topoisomerase II |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| YCH1 |
YGR203W |
Phosphatase with sequence similarity to Mih1p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SGS1 |
YMR190C |
RecQ family nucleolar DNA helicase |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SEN1 |
YLR430W |
ATP-dependent 5' to 3' RNA/DNA and DNA helicase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| SET1 |
YHR119W |
Histone methyltransferase, subunit of the COMPASS (Set1C) complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| RNR1 |
YER070W |
Major isoform of large subunit of ribonucleotide-diphosphate reductase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| RCO1 |
YMR075W |
Essential component of the Rpd3S histone deacetylase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MLP1 |
YKR095W |
Myosin-like protein associated with the nuclear envelope |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| IST2 |
YBR086C |
Cortical ER protein involved in ER-plasma membrane (PM) tethering |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MCM2 |
YBL023C |
Protein involved in DNA replication |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| RAD1 |
YPL022W |
Single-stranded DNA endonuclease (with Rad10p) |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| MMS2 |
YGL087C |
Ubiquitin-conjugating enzyme variant |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| MLH3 |
YPL164C |
Protein involved in DNA mismatch repair and meiotic recombination |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| PDS1 |
YDR113C |
Securin |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MAK11 |
YKL021C |
Protein involved in an early step of 60S ribosomal subunit biogenesis |
genetic |
1 |
1 |
1 |
Negative Genetic |
| KIN28 |
YDL108W |
Ser/Thr protein kinase and subunit of TFIIK, a TFIIH subassembly |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PAP2 |
YOL115W |
Non-canonical poly(A) polymerase |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| AIR1 |
YIL079C |
Zinc knuckle protein |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| DBF2 |
YGR092W |
Ser/Thr kinase involved in transcription and stress response |
genetic |
1 |
1 |
1 |
Negative Genetic |
| BUB3 |
YOR026W |
Kinetochore checkpoint WD40 repeat protein |
genetic |
1 |
1 |
1 |
Positive Genetic |
| MLP2 |
YIL149C |
Myosin-like protein associated with the nuclear envelope |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| CLN3 |
YAL040C |
G1 cyclin involved in cell cycle progression |
genetic |
1 |
1 |
1 |
Negative Genetic |
| INO2 |
YDR123C |
Transcription factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ARP6 |
YLR085C |
Actin-related protein that binds nucleosomes |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NOT5 |
YPR072W |
Component of the CCR4-NOT core complex, involved in mRNA decapping |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| APN1 |
YKL114C |
Major apurinic/apyrimidinic endonuclease |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| BUR6 |
YER159C |
Subunit of a heterodimeric NC2 transcription regulator complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| EXO1 |
YOR033C |
5'-3' exonuclease and flap-endonuclease |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| MGM1 |
YOR211C |
Mitochondrial GTPase, present in complex with Ugo1p and Fzo1p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MPT5 |
YGL178W |
mRNA-binding protein of the PUF family |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| POL32 |
YJR043C |
Third subunit of DNA polymerase delta |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| RAD2 |
YGR258C |
Single-stranded DNA endonuclease |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| ORC5 |
YNL261W |
Subunit of the origin recognition complex (ORC) |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| PBP1 |
YGR178C |
Component of glucose deprivation induced stress granules |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| REV3 |
YPL167C |
Catalytic subunit of DNA polymerase zeta |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| PRI1 |
YIR008C |
Subunit of DNA primase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| APN2 |
YBL019W |
Class II abasic (AP) endonuclease involved in repair of DNA damage |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| REV1 |
YOR346W |
Deoxycytidyl transferase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| REV7 |
YIL139C |
Accessory subunit of DNA polymerase zeta |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| BOL3 |
YAL046C |
Protein involved in Fe-S cluster transfer to mitochondrial clients |
genetic |
1 |
1 |
1 |
Negative Genetic |
| HRQ1 |
YDR291W |
3'-5' DNA helicase of the conserved RecQ family |
genetic |
1 |
1 |
1 |
Positive Genetic |
| GCD14 |
YJL125C |
Subunit of tRNA (1-methyladenosine) methyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RAD27 |
YKL113C |
5' to 3' exonuclease, 5' flap endonuclease |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| FCY1 |
YPR062W |
Cytosine deaminase |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| PHO91 |
YNR013C |
Low-affinity vacuolar phosphate transporter |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ENT4 |
YLL038C |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| GIS1 |
YDR096W |
Histone demethylase and transcription factor |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| ILM1 |
YJR118C |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CHO2 |
YGR157W |
Phosphatidylethanolamine methyltransferase (PEMT) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| EMI1 |
YDR512C |
Non-essential protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PIF1 |
YML061C |
DNA helicase, potent G-quadruplex DNA binder/unwinder |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
