Standard name Systematic name Name description Description
SLD2 YKL108W Single-stranded DNA origin-binding and annealing protein Single-stranded DNA origin-binding and annealing protein; required for initiation of DNA replication; phosphorylated in S phase by cyclin-dependent kinases (Cdks), promoting origin binding, DNA replication and Dpb11p complex formation; component of the preloading complex; binds the Mcm2-7p complex to prevent inappropriate Mcm2-7p interaction with the GINS complex in G1; required for S phase checkpoint; relative distribution to the nucleus increases upon DNA replication stress
Visualize the interactome of SLD2
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)
G1(P) 21

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.659 0.605 0.742
Mito 0.359 0.058 0.082
Nucleus 0.083 0.180 0.109
Vac/Vac Memb NaN 0.246 0.114

GFP localization & abundance

GFP localization GFP abundance
nucleus 656

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
SLD2 1 0 0 1 5

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
DPB11 YJL090C DNA replication initiation protein physical 18 3 12 Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Two-hybrid, Two-hybrid, Two-hybrid, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western, Two-hybrid, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Affinity Capture-Western, Two-hybrid, Affinity Capture-Western
DPB11 YJL090C DNA replication initiation protein genetic 11 4 6 Dosage Lethality, Dosage Rescue, Dosage Rescue, Dosage Rescue, Dosage Rescue, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Dosage Rescue, Synthetic Lethality, Dosage Growth Defect
MCM2 YBL023C Protein involved in DNA replication physical 5 2 3 Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Affinity Capture-Western, Reconstituted Complex
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit physical 4 1 4 Biochemical Activity, Biochemical Activity, Biochemical Activity, Biochemical Activity
CDC45 YLR103C DNA replication initiation factor genetic 3 3 2 Synthetic Growth Defect, Dosage Growth Defect, Phenotypic Enhancement
DDC1 YPL194W DNA damage checkpoint protein genetic 3 3 2 Dosage Lethality, Phenotypic Enhancement, Synthetic Growth Defect
MCM4 YPR019W Essential helicase component of heterohexameric MCM2-7 complexes physical 3 2 2 Reconstituted Complex, Reconstituted Complex, Affinity Capture-Western
RPD3 YNL330C Histone deacetylase, component of both the Rpd3S and Rpd3L complexes genetic 3 3 1 Phenotypic Enhancement, Dosage Growth Defect, Phenotypic Suppression
POL2 YNL262W Catalytic subunit of DNA polymerase (II) epsilon physical 2 2 2 Reconstituted Complex, Affinity Capture-Western
CLB5 YPR120C B-type cyclin involved in DNA replication during S phase physical 2 2 2 Affinity Capture-Western, Biochemical Activity
CLB5 YPR120C B-type cyclin involved in DNA replication during S phase genetic 2 2 2 Phenotypic Suppression, Synthetic Growth Defect
FKH1 YIL131C Forkhead family transcription factor regulation 2 1 2 chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation-chip evidence
PSF1 YDR013W Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) physical 2 1 2 Affinity Capture-Western, Affinity Capture-Western
HSC82 YMR186W Cytoplasmic chaperone of the Hsp90 family genetic 2 1 2 Synthetic Growth Defect, Synthetic Growth Defect
MAM33 YIL070C Acidic protein of the mitochondrial matrix physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
HSP82 YPL240C Hsp90 chaperone genetic 2 1 2 Synthetic Growth Defect, Synthetic Growth Defect
DMA1 YHR115C Ubiquitin-protein ligase (E3) physical 2 2 1 Two-hybrid, Reconstituted Complex
SLD7 YOR060C Protein with a role in chromosomal DNA replication genetic 2 2 1 Dosage Growth Defect, Phenotypic Enhancement
DBF4 YDR052C Regulatory subunit of Cdc7p-Dbf4p kinase complex genetic 2 2 1 Dosage Growth Defect, Phenotypic Enhancement
MCM5 YLR274W Component of the Mcm2-7 hexameric helicase complex physical 2 1 1 Reconstituted Complex, Reconstituted Complex
MCM6 YGL201C Protein involved in DNA replication physical 2 1 1 Reconstituted Complex, Reconstituted Complex
SPC105 YGL093W Subunit of a kinetochore-microtubule binding complex genetic 2 1 1 Synthetic Rescue, Synthetic Rescue
MCM3 YEL032W Protein involved in DNA replication physical 2 1 1 Reconstituted Complex, Reconstituted Complex
MCM7 YBR202W Component of the Mcm2-7 hexameric helicase complex physical 2 1 1 Reconstituted Complex, Reconstituted Complex
IXR1 YKL032C Transcriptional repressor that regulates hypoxic genes during normoxia regulation 1 1 1 DNA to cDNA expression microarray evidence
SPT10 YJL127C Histone H3 acetylase with a role in transcriptional regulation regulation 1 1 1 DNA to cDNA expression microarray evidence
PSF1 YDR013W Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) genetic 1 1 1 Dosage Rescue
CKA1 YIL035C Alpha catalytic subunit of casein kinase 2 (CK2) physical 1 1 1 Affinity Capture-MS
NIP7 YPL211W Nucleolar protein required for 60S ribosome subunit biogenesis genetic 1 1 1 Synthetic Growth Defect
GUS1 YGL245W Glutamyl-tRNA synthetase (GluRS) physical 1 1 1 Affinity Capture-MS
CDC14 YFR028C Protein phosphatase required for mitotic exit physical 1 1 1 Biochemical Activity
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit genetic 1 1 1 Dosage Lethality
COP1 YDL145C Alpha subunit of COPI vesicle coatomer complex physical 1 1 1 Affinity Capture-MS
CTF18 YMR078C Subunit of a complex with Ctf8p genetic 1 1 1 Dosage Growth Defect
CYS4 YGR155W Cystathionine beta-synthase physical 1 1 1 Affinity Capture-MS
DPB2 YPR175W Second largest subunit of DNA polymerase II (DNA polymerase epsilon) physical 1 1 1 Affinity Capture-Western
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
IPP1 YBR011C Cytoplasmic inorganic pyrophosphatase (PPase) physical 1 1 1 Affinity Capture-MS
POL2 YNL262W Catalytic subunit of DNA polymerase (II) epsilon genetic 1 1 1 Dosage Rescue
CDC6 YJL194W Essential ATP-binding protein required for DNA replication genetic 1 1 1 Phenotypic Enhancement
SEC7 YDR170C Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors genetic 1 1 1 Synthetic Growth Defect
PUF3 YLL013C Protein of the mitochondrial outer surface physical 1 1 1 Affinity Capture-RNA
LSM12 YHR121W Protein of unknown function that may function in RNA processing physical 1 1 1 Affinity Capture-MS
MDH1 YKL085W Mitochondrial malate dehydrogenase physical 1 1 1 Affinity Capture-MS
ADH2 YMR303C Glucose-repressible alcohol dehydrogenase II physical 1 1 1 Affinity Capture-MS
CDC5 YMR001C Polo-like kinase required for mitotic exit physical 1 1 1 Biochemical Activity
MGE1 YOR232W Mitochondrial matrix cochaperone physical 1 1 1 Affinity Capture-MS
PST2 YDR032C FMN-dependent NAD(P)H:quinone oxidoreductase physical 1 1 1 Affinity Capture-Western
DSS1 YMR287C 3'-5' exoribonuclease physical 1 1 1 Affinity Capture-MS
ADH4 YGL256W Alcohol dehydrogenase isoenzyme type IV physical 1 1 1 Affinity Capture-MS
CDC4 YFL009W F-box protein required for both the G1/S and G2/M phase transitions physical 1 1 1 Reconstituted Complex
SRP1 YNL189W Karyopherin alpha homolog physical 1 1 1 Affinity Capture-MS
TRL1 YJL087C tRNA ligase physical 1 1 1 Affinity Capture-MS
TAL1 YLR354C Transaldolase, enzyme in the non-oxidative pentose phosphate pathway physical 1 1 1 Affinity Capture-MS
SLD5 YDR489W Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) physical 1 1 1 Affinity Capture-Western
SLD3 YGL113W Protein involved in the initiation of DNA replication physical 1 1 1 Reconstituted Complex
SLD3 YGL113W Protein involved in the initiation of DNA replication genetic 1 1 1 Dosage Growth Defect
SLD7 YOR060C Protein with a role in chromosomal DNA replication physical 1 1 1 Reconstituted Complex
SML1 YML058W Ribonucleotide reductase inhibitor genetic 1 1 1 Phenotypic Suppression
PTC7 YHR076W Type 2C serine/threonine protein phosphatase (PP2C) physical 1 1 1 Affinity Capture-MS
GAL7 YBR018C Galactose-1-phosphate uridyl transferase physical 1 1 1 Affinity Capture-MS
MCK1 YNL307C Dual-specificity ser/thr and tyrosine protein kinase physical 1 1 1 Biochemical Activity
CDC7 YDL017W S/T kinase and catalytic subunit of DDK (Dbf4-dependent kinase) physical 1 1 1 Biochemical Activity
PEX13 YLR191W Peroxisomal importomer complex component physical 1 1 1 Two-hybrid
CHL1 YPL008W Probable DNA helicase genetic 1 1 1 Dosage Growth Defect
PSF3 YOL146W Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) genetic 1 1 1 Dosage Rescue
MSA1 YOR066W Activator of G1-specific transcription factors MBF and SBF genetic 1 1 1 Dosage Rescue
SIC1 YLR079W Cyclin-dependent kinase inhibitor (CKI) genetic 1 1 1 Phenotypic Suppression