NPL4 |
YBR170C |
Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase |
physical |
20 |
5 |
14 |
Affinity Capture-MS, Affinity Capture-MS, Two-hybrid, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Two-hybrid, Two-hybrid, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Reconstituted Complex, Co-crystal Structure, Reconstituted Complex, Affinity Capture-Western |
CDC48 |
YDL126C |
AAA ATPase with protein-unfoldase activity |
physical |
19 |
3 |
14 |
Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Reconstituted Complex, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western |
UBX2 |
YML013W |
Bridging factor involved in ER-associated protein degradation (ERAD) |
physical |
6 |
3 |
5 |
Affinity Capture-Western, Affinity Capture-Western, PCA, Affinity Capture-MS, PCA, Affinity Capture-Western |
DOA1 |
YKL213C |
WD-repeat protein involved in ubiquitin-mediated protein degradation |
physical |
4 |
3 |
3 |
Co-purification, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western |
ERG3 |
YLR056W |
C-5 sterol desaturase |
genetic |
3 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic |
UFD2 |
YDL190C |
Ubiquitin (Ub) chain assembly factor (E4) |
physical |
3 |
3 |
2 |
Co-purification, Affinity Capture-Western, Affinity Capture-MS |
DER1 |
YBR201W |
ER membrane protein that promotes export of misfolded polypeptides |
physical |
3 |
2 |
2 |
Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western |
HMG2 |
YLR450W |
HMG-CoA reductase |
physical |
3 |
1 |
2 |
Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western |
CDC48 |
YDL126C |
AAA ATPase with protein-unfoldase activity |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Negative Genetic |
SEC62 |
YPL094C |
Essential subunit of Sec63 complex |
genetic |
2 |
2 |
2 |
Negative Genetic, Synthetic Rescue |
SGS1 |
YMR190C |
RecQ family nucleolar DNA helicase |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Negative Genetic |
UBI4 |
YLL039C |
Ubiquitin |
physical |
2 |
2 |
2 |
Affinity Capture-Western, Reconstituted Complex |
DIA2 |
YOR080W |
Origin-binding F-box protein |
genetic |
2 |
2 |
2 |
Negative Genetic, Synthetic Growth Defect |
HRD1 |
YOL013C |
Ubiquitin-protein ligase involved in ER-associated degradation (ERAD) |
physical |
2 |
2 |
2 |
Affinity Capture-Western, Reconstituted Complex |
FKH1 |
YIL131C |
Forkhead family transcription factor |
regulation |
2 |
1 |
2 |
chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation-chip evidence |
NOP12 |
YOL041C |
Nucleolar protein involved in pre-25S rRNA processing |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
BGL2 |
YGR282C |
Endo-beta-1,3-glucanase |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
CRN1 |
YLR429W |
Coronin |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
MGA2 |
YIR033W |
ER membrane protein involved in regulation of OLE1 transcription |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
IDH1 |
YNL037C |
Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
AXL1 |
YPR122W |
Haploid specific endoprotease of a-factor mating pheromone |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
TEF4 |
YKL081W |
Gamma subunit of translational elongation factor eEF1B |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
ESC2 |
YDR363W |
Sumo-like domain protein |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
RPN4 |
YDL020C |
Transcription factor that stimulates expression of proteasome genes |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
IRC3 |
YDR332W |
Double-stranded DNA-dependent helicase of the DExH/D-box family |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
RPL43A |
YPR043W |
Ribosomal 60S subunit protein L43A |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
SLM3 |
YDL033C |
tRNA-specific 2-thiouridylase |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
SLD5 |
YDR489W |
Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) |
physical |
2 |
1 |
2 |
Affinity Capture-Western, Affinity Capture-Western |
AGE1 |
YDR524C |
ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
UBX5 |
YDR330W |
UBX domain-containing protein that interacts with Cdc48p |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
EOS1 |
YNL080C |
Protein involved in N-glycosylation |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
COX10 |
YPL172C |
Heme A:farnesyltransferase |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
YJL213W |
YJL213W |
Protein of unknown function that may interact with ribosomes |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
VPS27 |
YNR006W |
Endosomal protein that forms a complex with Hse1p |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
COQ2 |
YNR041C |
Para hydroxybenzoate polyprenyl transferase |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
MDM35 |
YKL053C-A |
Mitochondrial intermembrane space protein |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
SDH4 |
YDR178W |
Membrane anchor subunit of succinate dehydrogenase (SDH) |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
HPM1 |
YIL110W |
AdoMet-dependent methyltransferase |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
UBP1 |
YDL122W |
Ubiquitin-specific protease |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
SRC1 |
YML034W |
Inner nuclear membrane protein |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
PAP1 |
YKR002W |
Poly(A) polymerase |
physical |
2 |
2 |
1 |
Two-hybrid, Reconstituted Complex |
UBR1 |
YGR184C |
E3 ubiquitin ligase (N-recognin) |
genetic |
2 |
2 |
1 |
Synthetic Rescue, Phenotypic Suppression |
SAN1 |
YDR143C |
Ubiquitin-protein ligase |
genetic |
2 |
2 |
1 |
Synthetic Rescue, Phenotypic Suppression |
OTU1 |
YFL044C |
Deubiquitylation enzyme that binds to the chaperone-ATPase Cdc48p |
physical |
2 |
2 |
1 |
Reconstituted Complex, Affinity Capture-Western |
ESA1 |
YOR244W |
Catalytic subunit of the histone acetyltransferase complex (NuA4) |
genetic |
2 |
1 |
1 |
Synthetic Lethality, Synthetic Lethality |
RAD52 |
YML032C |
Protein involved in homologous recombination |
physical |
2 |
1 |
1 |
Affinity Capture-Western, Affinity Capture-Western |
STE6 |
YKL209C |
Plasma membrane ATP-binding cassette (ABC) transporter |
physical |
2 |
1 |
1 |
Affinity Capture-Western, Affinity Capture-Western |
UBX5 |
YDR330W |
UBX domain-containing protein that interacts with Cdc48p |
physical |
2 |
1 |
1 |
Affinity Capture-MS, Affinity Capture-MS |
VTI1 |
YMR197C |
Protein involved in cis-Golgi membrane traffic |
genetic |
2 |
1 |
1 |
Synthetic Rescue, Synthetic Rescue |
SFP1 |
YLR403W |
Regulates transcription of ribosomal protein and biogenesis genes |
regulation |
1 |
1 |
1 |
DNA to cDNA expression microarray evidence |
FKH2 |
YNL068C |
Forkhead family transcription factor |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation- exonuclease evidence |
RPN4 |
YDL020C |
Transcription factor that stimulates expression of proteasome genes |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
XBP1 |
YIL101C |
Transcriptional repressor |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
REB1 |
YBR049C |
RNA polymerase I enhancer binding protein |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
CYC8 |
YBR112C |
General transcriptional co-repressor |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
SPT3 |
YDR392W |
Subunit of the SAGA and SAGA-like transcriptional regulatory complexes |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
MCM1 |
YMR043W |
Transcription factor |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
PSF1 |
YDR013W |
Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
PSF2 |
YJL072C |
Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
RPB2 |
YOR151C |
RNA polymerase II second largest subunit B150 |
genetic |
1 |
1 |
1 |
Negative Genetic |
NSE1 |
YLR007W |
Component of the SMC5-SMC6 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
IKI3 |
YLR384C |
Subunit of Elongator complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
NIP7 |
YPL211W |
Nucleolar protein required for 60S ribosome subunit biogenesis |
genetic |
1 |
1 |
1 |
Negative Genetic |
PRP19 |
YLL036C |
Splicing factor associated with the spliceosome |
genetic |
1 |
1 |
1 |
Negative Genetic |
NSE4 |
YDL105W |
Component of the SMC5-SMC6 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
NSE5 |
YML023C |
Component of the SMC5-SMC6 complex |
physical |
1 |
1 |
1 |
Two-hybrid |
RRP4 |
YHR069C |
Exosome non-catalytic core component |
genetic |
1 |
1 |
1 |
Negative Genetic |
RRP42 |
YDL111C |
Exosome non-catalytic core component |
genetic |
1 |
1 |
1 |
Negative Genetic |
RPC17 |
YJL011C |
RNA polymerase III subunit C17 |
genetic |
1 |
1 |
1 |
Negative Genetic |
RPC34 |
YNR003C |
RNA polymerase III subunit C34 |
genetic |
1 |
1 |
1 |
Negative Genetic |
RPO31 |
YOR116C |
RNA polymerase III largest subunit C160 |
genetic |
1 |
1 |
1 |
Negative Genetic |
RSC9 |
YML127W |
Component of the RSC chromatin remodeling complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
RPN1 |
YHR027C |
Non-ATPase base subunit of the 19S RP of the 26S proteasome |
genetic |
1 |
1 |
1 |
Negative Genetic |
RPN5 |
YDL147W |
Subunit of the CSN and 26S proteasome lid complexes |
genetic |
1 |
1 |
1 |
Negative Genetic |
RPN6 |
YDL097C |
Essential, non-ATPase regulatory subunit of the 26S proteasome lid |
genetic |
1 |
1 |
1 |
Negative Genetic |
RPN7 |
YPR108W |
Essential non-ATPase regulatory subunit of the 26S proteasome |
genetic |
1 |
1 |
1 |
Negative Genetic |
RPT1 |
YKL145W |
ATPase of the 19S regulatory particle of the 26S proteasome |
genetic |
1 |
1 |
1 |
Negative Genetic |
ACT1 |
YFL039C |
Actin, structural protein in cytoskeleton |
genetic |
1 |
1 |
1 |
Negative Genetic |
PRE10 |
YOR362C |
Alpha 7 subunit of the 20S proteasome |
genetic |
1 |
1 |
1 |
Negative Genetic |
CCR4 |
YAL021C |
Component of the CCR4-NOT transcriptional complex |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
CDC11 |
YJR076C |
Component of the septin ring that is required for cytokinesis |
genetic |
1 |
1 |
1 |
Negative Genetic |
CDC45 |
YLR103C |
DNA replication initiation factor |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
COX5A |
YNL052W |
Subunit Va of cytochrome c oxidase |
genetic |
1 |
1 |
1 |
Positive Genetic |
DCP2 |
YNL118C |
Catalytic subunit of Dcp1p-Dcp2p decapping enzyme complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
FTH1 |
YBR207W |
Putative high affinity iron transporter |
genetic |
1 |
1 |
1 |
Negative Genetic |
DHH1 |
YDL160C |
Cytoplasmic DEAD-box helicase and mRNA decapping activator |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
AEP2 |
YMR282C |
Mitochondrial protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
LCB2 |
YDR062W |
Component of serine palmitoyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
MCM5 |
YLR274W |
Component of the Mcm2-7 hexameric helicase complex |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
MCM6 |
YGL201C |
Protein involved in DNA replication |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
COG3 |
YER157W |
Essential component of the conserved oligomeric Golgi complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
HRR25 |
YPL204W |
Conserved casein kinase, monopolin subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
NPL4 |
YBR170C |
Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
NUP159 |
YIL115C |
FG-nucleoporin component of central core of the nuclear pore complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
IDH2 |
YOR136W |
Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase |
genetic |
1 |
1 |
1 |
Negative Genetic |
PRE4 |
YFR050C |
Beta 7 subunit of the 20S proteasome |
genetic |
1 |
1 |
1 |
Negative Genetic |
PUB1 |
YNL016W |
Poly (A)+ RNA-binding protein |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RAD23 |
YEL037C |
Protein with ubiquitin-like N terminus |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
NUT2 |
YPR168W |
Subunit of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
PHO23 |
YNL097C |
Component of the Rpd3L histone deacetylase complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
SEC63 |
YOR254C |
Essential subunit of Sec63 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
SLY1 |
YDR189W |
Hydrophilic protein involved in ER/Golgi vesicle trafficking |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
PRP9 |
YDL030W |
Subunit of the SF3a splicing factor complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
SNU66 |
YOR308C |
Component of the U4/U6.U5 snRNP complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
SRP54 |
YPR088C |
Signal recognition particle (SRP) subunit (homolog of mammalian SRP54) |
genetic |
1 |
1 |
1 |
Negative Genetic |
SUA7 |
YPR086W |
Transcription factor TFIIB |
genetic |
1 |
1 |
1 |
Negative Genetic |
TAF1 |
YGR274C |
TFIID subunit, involved in RNA pol II transcription initiation |
genetic |
1 |
1 |
1 |
Negative Genetic |
MCM2 |
YBL023C |
Protein involved in DNA replication |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
RGC1 |
YPR115W |
Putative regulator of the Fps1p glycerol channel |
genetic |
1 |
1 |
1 |
Negative Genetic |
RPT4 |
YOR259C |
ATPase of the 19S regulatory particle of the 26S proteasome |
genetic |
1 |
1 |
1 |
Negative Genetic |
DRS2 |
YAL026C |
Trans-golgi network aminophospholipid translocase (flippase) |
genetic |
1 |
1 |
1 |
Positive Genetic |
PUF3 |
YLL013C |
Protein of the mitochondrial outer surface |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
BBC1 |
YJL020C |
Protein possibly involved in assembly of actin patches |
physical |
1 |
1 |
1 |
Two-hybrid |
CDC53 |
YDL132W |
Cullin |
genetic |
1 |
1 |
1 |
Negative Genetic |
RVS161 |
YCR009C |
Amphiphysin-like lipid raft protein |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
FDO1 |
YMR144W |
Protein involved in directionality of mating type switching |
genetic |
1 |
1 |
1 |
Negative Genetic |
QCR2 |
YPR191W |
Subunit 2 of ubiquinol cytochrome-c reductase (Complex III) |
genetic |
1 |
1 |
1 |
Negative Genetic |
UBI4 |
YLL039C |
Ubiquitin |
genetic |
1 |
1 |
1 |
Dosage Rescue |
RSP5 |
YER125W |
NEDD4 family E3 ubiquitin ligase |
genetic |
1 |
1 |
1 |
Negative Genetic |
EST1 |
YLR233C |
TLC1 RNA-associated factor involved in telomere length regulation |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
MAK11 |
YKL021C |
Protein involved in an early step of 60S ribosomal subunit biogenesis |
genetic |
1 |
1 |
1 |
Negative Genetic |
RAS2 |
YNL098C |
GTP-binding protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
FZO1 |
YBR179C |
Mitofusin, protein involved in mitochondrial outer membrane fusion |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
ELG1 |
YOR144C |
Subunit of an alternative replication factor C complex |
physical |
1 |
1 |
1 |
Two-hybrid |
MCM4 |
YPR019W |
Essential helicase component of heterohexameric MCM2-7 complexes |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
FCF1 |
YDR339C |
PINc domain endonuclease |
genetic |
1 |
1 |
1 |
Negative Genetic |
GAL2 |
YLR081W |
Galactose permease |
genetic |
1 |
1 |
1 |
Negative Genetic |
CDC7 |
YDL017W |
S/T kinase and catalytic subunit of DDK (Dbf4-dependent kinase) |
genetic |
1 |
1 |
1 |
Negative Genetic |
ERG11 |
YHR007C |
Lanosterol 14-alpha-demethylase |
genetic |
1 |
1 |
1 |
Negative Genetic |
DAD1 |
YDR016C |
Essential subunit of the Dam1 complex (aka DASH complex) |
genetic |
1 |
1 |
1 |
Negative Genetic |
DDI1 |
YER143W |
Aspartic-type endopeptidase |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
BIM1 |
YER016W |
Microtubule plus end-tracking protein |
physical |
1 |
1 |
1 |
Two-hybrid |
SMT3 |
YDR510W |
Ubiquitin-like protein of the SUMO family |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
SMT3 |
YDR510W |
Ubiquitin-like protein of the SUMO family |
genetic |
1 |
1 |
1 |
Negative Genetic |
MOB2 |
YFL034C-B |
Activator of Cbk1p kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
NDC80 |
YIL144W |
Component of the kinetochore-associated Ndc80 complex |
physical |
1 |
1 |
1 |
Two-hybrid |
HSP10 |
YOR020C |
Mitochondrial matrix co-chaperonin |
genetic |
1 |
1 |
1 |
Negative Genetic |
UBC9 |
YDL064W |
SUMO-conjugating enzyme involved in the Smt3p conjugation pathway |
genetic |
1 |
1 |
1 |
Negative Genetic |
NUR1 |
YDL089W |
Protein involved in regulation of mitotic exit |
physical |
1 |
1 |
1 |
Two-hybrid |
FMP40 |
YPL222W |
Mitochondrial AMPylator in the pseudokinase selenoprotein-O family |
physical |
1 |
1 |
1 |
Two-hybrid |
APC5 |
YOR249C |
Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) |
genetic |
1 |
1 |
1 |
Negative Genetic |
APC11 |
YDL008W |
Catalytic core subunit, Anaphase-Promoting Complex/Cyclosome (APC/C) |
genetic |
1 |
1 |
1 |
Negative Genetic |
MCM1 |
YMR043W |
Transcription factor |
genetic |
1 |
1 |
1 |
Positive Genetic |
ELO3 |
YLR372W |
Elongase |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
KAR9 |
YPL269W |
Spindle positioning factor |
physical |
1 |
1 |
1 |
Two-hybrid |
MCM3 |
YEL032W |
Protein involved in DNA replication |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
PAN1 |
YIR006C |
Part of actin cytoskeleton-regulatory complex Pan1p-Sla1p-End3p |
genetic |
1 |
1 |
1 |
Negative Genetic |
SEC61 |
YLR378C |
Conserved ER protein translocation channel |
genetic |
1 |
1 |
1 |
Positive Genetic |
SED5 |
YLR026C |
cis-Golgi t-SNARE syntaxin |
genetic |
1 |
1 |
1 |
Positive Genetic |
SSS1 |
YDR086C |
Subunit of the Sec61p translocation complex (Sec61p-Sss1p-Sbh1p) |
genetic |
1 |
1 |
1 |
Negative Genetic |
TOM40 |
YMR203W |
Component of the TOM (translocase of outer membrane) complex |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
UBA2 |
YDR390C |
Subunit of heterodimeric nuclear SUMO activating enzyme E1 with Aos1p |
physical |
1 |
1 |
1 |
Two-hybrid |
SNX4 |
YJL036W |
Sorting nexin |
genetic |
1 |
1 |
1 |
Positive Genetic |
EMC5 |
YIL027C |
Member of conserved ER transmembrane complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
MCM7 |
YBR202W |
Component of the Mcm2-7 hexameric helicase complex |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
SPC42 |
YKL042W |
Central plaque component of spindle pole body (SPB) |
physical |
1 |
1 |
1 |
Two-hybrid |
SNM1 |
YDR478W |
Ribonuclease MRP complex subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
PBP1 |
YGR178C |
Component of glucose deprivation induced stress granules |
physical |
1 |
1 |
1 |
Two-hybrid |
PFY1 |
YOR122C |
Profilin |
genetic |
1 |
1 |
1 |
Negative Genetic |
LRS4 |
YDR439W |
Nucleolar protein that forms a complex with Csm1p |
physical |
1 |
1 |
1 |
Two-hybrid |
RPL18B |
YNL301C |
Ribosomal 60S subunit protein L18B |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
PIN3 |
YPR154W |
Negative regulator of actin nucleation-promoting factor activity |
physical |
1 |
1 |
1 |
Two-hybrid |
PDS5 |
YMR076C |
Cohesion maintenance factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
ROG3 |
YFR022W |
Alpha-arrestin involved in ubiquitin-dependent endocytosis |
genetic |
1 |
1 |
1 |
Negative Genetic |
SPT23 |
YKL020C |
ER membrane protein involved in regulation of OLE1 transcription |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
PAM17 |
YKR065C |
Constituent of the TIM23 complex |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
HRQ1 |
YDR291W |
3'-5' DNA helicase of the conserved RecQ family |
genetic |
1 |
1 |
1 |
Negative Genetic |
TRS23 |
YDR246W |
Core component of transport protein particle (TRAPP) complexes I-III |
genetic |
1 |
1 |
1 |
Positive Genetic |
COQ11 |
YLR290C |
Putative oxidoreductase, subunit of Coenzyme Q biosynthetic complexes |
genetic |
1 |
1 |
1 |
Negative Genetic |
BRL1 |
YHR036W |
Essential nuclear envelope/ER integral membrane protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
NDT80 |
YHR124W |
Meiosis-specific transcription factor |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
SSH1 |
YBR283C |
Subunit of the Ssh1 translocon complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
CUZ1 |
YNL155W |
Protein with a role in the ubiquitin-proteasome pathway |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
PSF3 |
YOL146W |
Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
APJ1 |
YNL077W |
Hsp40 chaperone with a role in SUMO-mediated protein degradation |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
DFM1 |
YDR411C |
Endoplasmic reticulum (ER) localized protein |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
AIM39 |
YOL053W |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
PUF2 |
YPR042C |
PUF family mRNA-binding protein |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
PYP1 |
YNL010W |
Sugar alcohol phosphatase |
genetic |
1 |
1 |
1 |
Negative Genetic |
CYT1 |
YOR065W |
Cytochrome c1 |
genetic |
1 |
1 |
1 |
Negative Genetic |
GPI19 |
YDR437W |
Subunit of GPI-GlcNAc transferase involved in synthesis of GlcNAc-PI |
genetic |
1 |
1 |
1 |
Positive Genetic |
UFD1 |
YGR048W |
Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
VHC1 |
YBR235W |
Vacuolar membrane cation-chloride cotransporter (CCC) |
genetic |
1 |
1 |
1 |
Negative Genetic |
XRN1 |
YGL173C |
Evolutionarily-conserved 5'-3' exonuclease |
genetic |
1 |
1 |
1 |
Negative Genetic |
YJR011C |
YJR011C |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
UFE1 |
YOR075W |
t-SNARE protein required for retrograde vesicular traffic |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
YJU2 |
YKL095W |
Essential protein required for pre-mRNA splicing |
genetic |
1 |
1 |
1 |
Negative Genetic |
YIR020C |
YIR020C |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
VPS24 |
YKL041W |
One of four subunits of the ESCRT-III complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
YNL115C |
YNL115C |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
YPR089W |
YPR089W |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
VPS4 |
YPR173C |
AAA-ATPase involved in multivesicular body (MVB) protein sorting |
genetic |
1 |
1 |
1 |
Negative Genetic |
RPS27A |
YKL156W |
Protein component of the small (40S) ribosomal subunit |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
RPL14A |
YKL006W |
Ribosomal 60S subunit protein L14A |
genetic |
1 |
1 |
1 |
Negative Genetic |
SSM4 |
YIL030C |
Membrane-embedded ubiquitin-protein ligase and retrotranslocase |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
UBX2 |
YML013W |
Bridging factor involved in ER-associated protein degradation (ERAD) |
genetic |
1 |
1 |
1 |
Negative Genetic |
SIC1 |
YLR079W |
Cyclin-dependent kinase inhibitor (CKI) |
genetic |
1 |
1 |
1 |
Positive Genetic |
BIG1 |
YHR101C |
Integral membrane protein of the endoplasmic reticulum |
genetic |
1 |
1 |
1 |
Negative Genetic |
RQC2 |
YPL009C |
Component of the Ribosome Quality Control (RQC) complex |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
PFA5 |
YDR459C |
Palmitoyltransferase with autoacylation activity |
genetic |
1 |
1 |
1 |
Positive Genetic |
CDC1 |
YDR182W |
Putative mannose-ethanolamine phosphate phosphodiesterase |
genetic |
1 |
1 |
1 |
Negative Genetic |
FLX1 |
YIL134W |
Mitochondrial flavin adenine dinucleotide transporter |
genetic |
1 |
1 |
1 |
Negative Genetic |
HMI1 |
YOL095C |
Mitochondrial inner membrane localized ATP-dependent DNA helicase |
genetic |
1 |
1 |
1 |
Negative Genetic |
RQC1 |
YDR333C |
Component of the ribosome quality control complex (RQC) |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
UBR2 |
YLR024C |
Cytoplasmic ubiquitin-protein ligase (E3) |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
SDH9 |
YJL045W |
Minor succinate dehydrogenase isozyme |
genetic |
1 |
1 |
1 |
Negative Genetic |
TGS1 |
YPL157W |
Trimethyl guanosine synthase, conserved nucleolar methyl transferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
TAD3 |
YLR316C |
Subunit of tRNA-specific adenosine-34 deaminase |
genetic |
1 |
1 |
1 |
Negative Genetic |
OCA6 |
YDR067C |
Cytoplasmic protein required for replication of Brome mosaic virus |
genetic |
1 |
1 |
1 |
Negative Genetic |
SDL1 |
YIL167W |
Blocked reading frame otherwise encoding L-serine dehydratase |
genetic |
1 |
1 |
1 |
Negative Genetic |
STS1 |
YIR011C |
Protein required for localizing proteasomes to the nucleus |
genetic |
1 |
1 |
1 |
Negative Genetic |