Standard name Systematic name Name description Description
VPS15 YBR097W Serine/threonine protein kinase involved in vacuolar protein sorting Serine/threonine protein kinase involved in vacuolar protein sorting; functions as a membrane-associated complex with Vps34p; active form recruits Vps34p to the Golgi membrane; interacts with the GDP-bound form of Gpa1p; myristoylated; a fraction is localized, with Vps34p, to nuclear pores at nucleus-vacuole junctions and may facilitate transcription elongation for genes positioned at the nuclear periphery
Visualize the interactome of VPS15
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.137 0.203 0.157
Endosome 0.696 0.535 0.660
SpindlePole 0.140 0.070 0.283
Vac/Vac Memb 0.307 0.295 0.094
Mito NaN 0.155 0.110
Peroxisome NaN NaN 0.113

GFP localization & abundance

GFP localization GFP abundance
endosome 279

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
VPS15 4 0 0 1 0

Enzyme information

Catalyzed reactions in Yeast8
r_2855 (phosphatidylinositol 3-kinase (1-18:1, 2-16:1), vacuolar membrane), r_2858 (phosphatidylinositol 3-kinase (1-18:0, 2-18:1), vacuolar membrane), r_2854 (phosphatidylinositol 3-kinase (1-18:0, 2-16:1), vacuolar membrane), r_2857 (phosphatidylinositol 3-kinase (1-16:1, 2-18:1), vacuolar membrane), r_2856 (phosphatidylinositol 3-kinase (1-16:0, 2-18:1), vacuolar membrane), r_2853 (phosphatidylinositol 3-kinase (1-16:1, 2-16:1), vacuolar membrane), r_2859 (phosphatidylinositol 3-kinase (1-18:1, 2-18:1), vacuolar membrane), r_2852 (phosphatidylinositol 3-kinase (1-16:0, 2-16:1), vacuolar membrane)

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
VPS34 YLR240W Phosphatidylinositol (PI) 3-kinase that synthesizes PI-3-phosphate physical 10 5 6 Affinity Capture-Western, Co-fractionation, Two-hybrid, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Co-crystal Structure
ATG14 YBR128C Autophagy-specific subunit of phosphatidylinositol 3-kinase complex I physical 5 2 4 Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western
VPS30 YPL120W Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II physical 4 2 3 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS
VPS38 YLR360W Part of a Vps34p phosphatidylinositol 3-kinase complex physical 3 2 3 Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS
GPA1 YHR005C Subunit of G protein involved in pheromone response physical 3 2 2 Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western
ATG38 YLR211C Homodimeric subunit of autophagy-specific PtdIns-3-kinase complex I physical 3 2 2 Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 2 1 2 Affinity Capture-RNA, Affinity Capture-RNA
PTC3 YBL056W Type 2C protein phosphatase (PP2C) physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
EPL1 YFL024C Subunit of NuA4, an essential histone H4/H2A acetyltransferase complex genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
ACS2 YLR153C Acetyl-coA synthetase isoform genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
SFP1 YLR403W Regulates transcription of ribosomal protein and biogenesis genes regulation 1 1 1 DNA to cDNA expression microarray evidence
MED4 YOR174W Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
YAP5 YIR018W Basic leucine zipper (bZIP) iron-sensing transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
STE18 YJR086W G protein gamma subunit regulation 1 1 1 qualitative western immunoblotting evidence
RVB1 YDR190C ATP-dependent DNA helicase, also known as pontin physical 1 1 1 Affinity Capture-MS
BRE1 YDL074C E3 ubiquitin ligase genetic 1 1 1 Synthetic Growth Defect
NAT3 YPR131C Catalytic subunit of the NatB N-terminal acetyltransferase genetic 1 1 1 Synthetic Lethality
CDC48 YDL126C AAA ATPase with protein-unfoldase activity physical 1 1 1 Affinity Capture-MS
DST1 YGL043W General transcription elongation factor TFIIS genetic 1 1 1 Negative Genetic
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
PEP1 YBL017C Type I transmembrane sorting receptor for multiple vacuolar hydrolases physical 1 1 1 Affinity Capture-MS
EMP24 YGL200C Component of the p24 complex physical 1 1 1 Affinity Capture-MS
FKS1 YLR342W Catalytic subunit of 1,3-beta-D-glucan synthase physical 1 1 1 Affinity Capture-MS
ERV25 YML012W Member of the p24 family involved in ER to Golgi transport physical 1 1 1 Affinity Capture-MS
ISW1 YBR245C ATPase subunit of imitation-switch (ISWI) class chromatin remodelers physical 1 1 1 Affinity Capture-RNA
PPH22 YDL188C Catalytic subunit of protein phosphatase 2A, PP2A genetic 1 1 1 Negative Genetic
RAD51 YER095W Strand exchange protein genetic 1 1 1 Synthetic Growth Defect
RAD52 YML032C Protein involved in homologous recombination genetic 1 1 1 Synthetic Growth Defect
PPH21 YDL134C Catalytic subunit of protein phosphatase 2A, PP2A genetic 1 1 1 Negative Genetic
PIL1 YGR086C Eisosome core component physical 1 1 1 Affinity Capture-MS
SEC21 YNL287W Gamma subunit of coatomer physical 1 1 1 Affinity Capture-MS
SEC23 YPR181C GTPase-activating protein, stimulates the GTPase activity of Sar1p physical 1 1 1 Affinity Capture-MS
SEC17 YBL050W Alpha-SNAP cochaperone physical 1 1 1 Affinity Capture-MS
TAF1 YGR274C TFIID subunit, involved in RNA pol II transcription initiation genetic 1 1 1 Synthetic Lethality
LTE1 YAL024C Protein similar to GDP/GTP exchange factors genetic 1 1 1 Synthetic Growth Defect
RAV1 YJR033C Subunit of RAVE complex (Rav1p, Rav2p, Skp1p) genetic 1 1 1 Synthetic Growth Defect
SNF7 YLR025W One of four subunits of the ESCRT-III complex physical 1 1 1 Affinity Capture-MS
VPS1 YKR001C Dynamin-like GTPase required for vacuolar sorting physical 1 1 1 Affinity Capture-MS
CDC53 YDL132W Cullin genetic 1 1 1 Negative Genetic
GET1 YGL020C Subunit of the GET complex genetic 1 1 1 Synthetic Lethality
GET2 YER083C Subunit of the GET complex genetic 1 1 1 Synthetic Growth Defect
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 1 1 1 Positive Genetic
UFD2 YDL190C Ubiquitin (Ub) chain assembly factor (E4) genetic 1 1 1 Negative Genetic
UBI4 YLL039C Ubiquitin physical 1 1 1 Reconstituted Complex
RVS167 YDR388W Calmodulin-binding actin-associated protein physical 1 1 1 Affinity Capture-MS
MRE11 YMR224C Nuclease subunit of the MRX complex with Rad50p and Xrs2p genetic 1 1 1 Synthetic Growth Defect
RAD50 YNL250W Subunit of MRX complex with Mre11p and Xrs2p genetic 1 1 1 Synthetic Growth Defect
SEC4 YFL005W Rab family GTPase physical 1 1 1 Affinity Capture-MS
DAK2 YFL053W Dihydroxyacetone kinase physical 1 1 1 PCA
NOP53 YPL146C Nucleolar protein genetic 1 1 1 Positive Genetic
PAP2 YOL115W Non-canonical poly(A) polymerase genetic 1 1 1 Synthetic Lethality
SSN8 YNL025C Cyclin-like component of RNA polymerase II holoenzyme genetic 1 1 1 Negative Genetic
DBF2 YGR092W Ser/Thr kinase involved in transcription and stress response genetic 1 1 1 Positive Genetic
FUS3 YBL016W Mitogen-activated serine/threonine protein kinase involved in mating genetic 1 1 1 Positive Genetic
MGT1 YDL200C DNA repair methyltransferase (6-O-methylguanine-DNA methylase) genetic 1 1 1 Negative Genetic
DID4 YKL002W Class E Vps protein of the ESCRT-III complex physical 1 1 1 Affinity Capture-MS
PEP12 YOR036W Target membrane receptor (t-SNARE) physical 1 1 1 Affinity Capture-MS
RSC1 YGR056W Component of the RSC chromatin remodeling complex genetic 1 1 1 Negative Genetic
RTG3 YBL103C bHLH/Zip transcription factor for retrograde (RTG) and TOR pathways genetic 1 1 1 Negative Genetic
SEC61 YLR378C Conserved ER protein translocation channel physical 1 1 1 Affinity Capture-MS
BET1 YIL004C Type II membrane protein required for vesicular transport physical 1 1 1 Affinity Capture-MS
SEC22 YLR268W R-SNARE protein physical 1 1 1 Affinity Capture-MS
TEL1 YBL088C Protein kinase primarily involved in telomere length regulation genetic 1 1 1 Phenotypic Enhancement
GOS1 YHL031C v-SNARE protein involved in Golgi transport physical 1 1 1 Affinity Capture-MS
SSO1 YPL232W Plasma membrane t-SNARE physical 1 1 1 Affinity Capture-MS
EMP47 YFL048C Integral membrane component of ER-derived COPII-coated vesicles physical 1 1 1 Affinity Capture-MS
SGM1 YJR134C Protein of unknown function genetic 1 1 1 Positive Genetic
SLA2 YNL243W Adaptor protein that links actin to clathrin and endocytosis genetic 1 1 1 Synthetic Lethality
SFT1 YKL006C-A Intra-Golgi v-SNARE physical 1 1 1 Affinity Capture-MS
AKR1 YDR264C Palmitoyl transferase involved in protein palmitoylation physical 1 1 1 Affinity Capture-MS
NNF2 YGR089W Protein that exhibits physical and genetic interactions with Rpb8p genetic 1 1 1 Negative Genetic
TOR1 YJR066W PIK-related protein kinase and rapamycin target genetic 1 1 1 Synthetic Growth Defect
VPS34 YLR240W Phosphatidylinositol (PI) 3-kinase that synthesizes PI-3-phosphate genetic 1 1 1 Dosage Rescue
YOP1 YPR028W Reticulon-interacting protein physical 1 1 1 Affinity Capture-MS
YPT52 YKR014C Endosomal Rab family GTPase physical 1 1 1 Affinity Capture-MS
YCK3 YER123W Palmitoylated vacuolar membrane-localized casein kinase I isoform physical 1 1 1 Affinity Capture-MS
YPT31 YER031C Rab family GTPase physical 1 1 1 Affinity Capture-MS
YPT7 YML001W Rab family GTPase physical 1 1 1 Affinity Capture-MS
VPS21 YOR089C Endosomal Rab family GTPase physical 1 1 1 Affinity Capture-MS
YPT1 YFL038C Rab family GTPase physical 1 1 1 Affinity Capture-MS
YIP3 YNL044W Protein localized to COPII vesicles physical 1 1 1 Affinity Capture-MS
VTI1 YMR197C Protein involved in cis-Golgi membrane traffic physical 1 1 1 Affinity Capture-MS
VPS15 YBR097W Serine/threonine protein kinase involved in vacuolar protein sorting physical 1 1 1 Affinity Capture-MS
XRS2 YDR369C FHA domain-containing component of the Mre11 complex genetic 1 1 1 Synthetic Growth Defect
YHR033W YHR033W Putative protein of unknown function genetic 1 1 1 Positive Genetic
DID2 YKR035W-A Class E protein of the vacuolar protein-sorting (Vps) pathway physical 1 1 1 Affinity Capture-MS
ENT5 YDR153C Protein containing an N-terminal epsin-like domain genetic 1 1 1 Negative Genetic
STV1 YMR054W Subunit a of the vacuolar-ATPase V0 domain physical 1 1 1 Affinity Capture-MS
COY1 YKL179C Golgi membrane protein with similarity to mammalian CASP physical 1 1 1 Affinity Capture-MS
SRS2 YJL092W DNA helicase and DNA-dependent ATPase genetic 1 1 1 Synthetic Growth Defect
PMR1 YGL167C High affinity Ca2+/Mn2+ P-type ATPase physical 1 1 1 Affinity Capture-MS
THP3 YPR045C Protein that may have a role in transcription elongation genetic 1 1 1 Negative Genetic
DNF1 YER166W Aminophospholipid translocase (flippase) physical 1 1 1 Affinity Capture-MS
PHB2 YGR231C Subunit of the prohibitin complex (Phb1p-Phb2p) genetic 1 1 1 Positive Genetic
RPS10A YOR293W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Positive Genetic
SVP26 YHR181W ER exit adaptor for Golgi mannosyltransferases physical 1 1 1 Affinity Capture-MS
RIF2 YLR453C Protein that binds to the Rap1p C-terminus genetic 1 1 1 Phenotypic Enhancement
SUM1 YDR310C Transcriptional repressor that regulates middle-sporulation genes genetic 1 1 1 Negative Genetic
SFT2 YBL102W Tetra-spanning membrane protein found mostly in the late Golgi physical 1 1 1 Affinity Capture-MS
NEO1 YIL048W Phospholipid translocase (flippase) physical 1 1 1 Affinity Capture-MS
LGE1 YPL055C Protein involved in histone H2B ubiquitination genetic 1 1 1 Synthetic Growth Defect
SIC1 YLR079W Cyclin-dependent kinase inhibitor (CKI) genetic 1 1 1 Negative Genetic
MSH1 YHR120W DNA-binding protein of the mitochondria genetic 1 1 1 Positive Genetic
SSP120 YLR250W Protein packaged into COPII vesicles for ER to Golgi trafficking physical 1 1 1 Affinity Capture-MS
TVP38 YKR088C Integral membrane protein physical 1 1 1 Affinity Capture-MS