Standard name Systematic name Name description Description
VPS34 YLR240W Phosphatidylinositol (PI) 3-kinase that synthesizes PI-3-phosphate Phosphatidylinositol (PI) 3-kinase that synthesizes PI-3-phosphate; forms membrane-associated signal transduction complex with Vps15p to regulate protein sorting; activated by the GTP-bound form of Gpa1p; a fraction is localized, with Vps15p, to nuclear pores at nucleus-vacuole junctions and may facilitate transcription elongation for genes positioned at the nuclear periphery
Visualize the interactome of VPS34
Links to external databases:
SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.105 0.145 0.163
Endosome 0.158 0.218 0.419
Mito 0.211 0.309 NaN
Nucleolus 0.421 0.164 0.140
Nucleus 0.053 NaN NaN
SpindlePole 0.211 0.127 0.465
Vac/Vac Memb 0.263 0.200 0.186

GFP localization & abundance

GFP localization GFP abundance
endosome 1080

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
VPS34 7 0 0 0 0

Enzyme information

Catalyzed reactions in Yeast8
r_2855 (phosphatidylinositol 3-kinase (1-18:1, 2-16:1), vacuolar membrane), r_2858 (phosphatidylinositol 3-kinase (1-18:0, 2-18:1), vacuolar membrane), r_2854 (phosphatidylinositol 3-kinase (1-18:0, 2-16:1), vacuolar membrane), r_2857 (phosphatidylinositol 3-kinase (1-16:1, 2-18:1), vacuolar membrane), r_2856 (phosphatidylinositol 3-kinase (1-16:0, 2-18:1), vacuolar membrane), r_2853 (phosphatidylinositol 3-kinase (1-16:1, 2-16:1), vacuolar membrane), r_2859 (phosphatidylinositol 3-kinase (1-18:1, 2-18:1), vacuolar membrane), r_2852 (phosphatidylinositol 3-kinase (1-16:0, 2-16:1), vacuolar membrane)

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
VPS15 YBR097W Serine/threonine protein kinase involved in vacuolar protein sorting physical 10 5 6 Affinity Capture-Western, Co-fractionation, Two-hybrid, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Co-crystal Structure
VPS30 YPL120W Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II physical 7 2 6 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
ATG14 YBR128C Autophagy-specific subunit of phosphatidylinositol 3-kinase complex I physical 5 2 4 Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western
ATG38 YLR211C Homodimeric subunit of autophagy-specific PtdIns-3-kinase complex I physical 5 4 2 Affinity Capture-MS, Affinity Capture-Western, Two-hybrid, Reconstituted Complex, Reconstituted Complex
VPS38 YLR360W Part of a Vps34p phosphatidylinositol 3-kinase complex physical 4 2 4 Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
GPA1 YHR005C Subunit of G protein involved in pheromone response physical 2 2 1 Affinity Capture-Western, Reconstituted Complex
HDA1 YNL021W Catalytic subunit of class II HDA1 histone deacetylase complex genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
EPL1 YFL024C Subunit of NuA4, an essential histone H4/H2A acetyltransferase complex genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
XBP1 YIL101C Transcriptional repressor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
BRE1 YDL074C E3 ubiquitin ligase genetic 1 1 1 Synthetic Lethality
CDC48 YDL126C AAA ATPase with protein-unfoldase activity physical 1 1 1 Affinity Capture-MS
SPT16 YGL207W Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) physical 1 1 1 Affinity Capture-MS
PEP1 YBL017C Type I transmembrane sorting receptor for multiple vacuolar hydrolases physical 1 1 1 Affinity Capture-MS
ASF1 YJL115W Nucleosome assembly factor genetic 1 1 1 Synthetic Lethality
CHC1 YGL206C Clathrin heavy chain physical 1 1 1 Affinity Capture-MS
CTF18 YMR078C Subunit of a complex with Ctf8p genetic 1 1 1 Synthetic Growth Defect
EMP24 YGL200C Component of the p24 complex physical 1 1 1 Affinity Capture-MS
ERP1 YAR002C-A Member of the p24 family involved in ER to Golgi transport physical 1 1 1 Affinity Capture-MS
FKS1 YLR342W Catalytic subunit of 1,3-beta-D-glucan synthase physical 1 1 1 Affinity Capture-MS
FTH1 YBR207W Putative high affinity iron transporter physical 1 1 1 Affinity Capture-MS
ERV25 YML012W Member of the p24 family involved in ER to Golgi transport physical 1 1 1 Affinity Capture-MS
ISW1 YBR245C ATPase subunit of imitation-switch (ISWI) class chromatin remodelers physical 1 1 1 Affinity Capture-RNA
MYO2 YOR326W Type V myosin motor involved in actin-based transport of cargos genetic 1 1 1 Negative Genetic
PEP3 YLR148W Component of CORVET membrane tethering complex physical 1 1 1 Affinity Capture-MS
PTC3 YBL056W Type 2C protein phosphatase (PP2C) physical 1 1 1 Affinity Capture-MS
RAD51 YER095W Strand exchange protein genetic 1 1 1 Synthetic Growth Defect
RAD52 YML032C Protein involved in homologous recombination genetic 1 1 1 Synthetic Growth Defect
PIL1 YGR086C Eisosome core component physical 1 1 1 Affinity Capture-MS
SEC21 YNL287W Gamma subunit of coatomer physical 1 1 1 Affinity Capture-MS
SEC23 YPR181C GTPase-activating protein, stimulates the GTPase activity of Sar1p physical 1 1 1 Affinity Capture-MS
SEC17 YBL050W Alpha-SNAP cochaperone physical 1 1 1 Affinity Capture-MS
SLY1 YDR189W Hydrophilic protein involved in ER/Golgi vesicle trafficking physical 1 1 1 Affinity Capture-MS
ATG9 YDL149W Transmembrane protein involved in forming Cvt and autophagic vesicles physical 1 1 1 Affinity Capture-MS
LTE1 YAL024C Protein similar to GDP/GTP exchange factors genetic 1 1 1 Synthetic Growth Defect
VMA1 YDL185W Subunit A of the V1 peripheral membrane domain of V-ATPase genetic 1 1 1 Synthetic Lethality
VMA2 YBR127C Subunit B of V1 peripheral membrane domain of vacuolar H+-ATPase genetic 1 1 1 Synthetic Lethality
SNF7 YLR025W One of four subunits of the ESCRT-III complex physical 1 1 1 Affinity Capture-MS
PEP5 YMR231W Histone E3 ligase, component of CORVET membrane tethering complex physical 1 1 1 Affinity Capture-MS
TLG1 YDR468C Essential t-SNARE that mediates fusion of vesicles with the late Golgi physical 1 1 1 Affinity Capture-MS
VPS1 YKR001C Dynamin-like GTPase required for vacuolar sorting physical 1 1 1 Affinity Capture-MS
RAD54 YGL163C DNA-dependent ATPase that stimulates strand exchange genetic 1 1 1 Synthetic Growth Defect
GET1 YGL020C Subunit of the GET complex genetic 1 1 1 Synthetic Growth Defect
GET2 YER083C Subunit of the GET complex genetic 1 1 1 Synthetic Growth Defect
ATG11 YPR049C Adapter protein for pexophagy and the Cvt targeting pathway physical 1 1 1 Affinity Capture-MS
RAD55 YDR076W Protein that stimulates strand exchange genetic 1 1 1 Synthetic Growth Defect
SEC18 YBR080C AAA ATPase and SNARE disassembly chaperone physical 1 1 1 Affinity Capture-MS
SAR1 YPL218W ARF family GTPase physical 1 1 1 Affinity Capture-MS
MRE11 YMR224C Nuclease subunit of the MRX complex with Rad50p and Xrs2p genetic 1 1 1 Synthetic Growth Defect
RAD50 YNL250W Subunit of MRX complex with Mre11p and Xrs2p genetic 1 1 1 Synthetic Growth Defect
SEC4 YFL005W Rab family GTPase physical 1 1 1 Affinity Capture-MS
ELG1 YOR144C Subunit of an alternative replication factor C complex genetic 1 1 1 Synthetic Growth Defect
VPS21 YOR089C Endosomal Rab family GTPase physical 1 1 1 Affinity Capture-MS
RAD53 YPL153C DNA damage response kinase genetic 1 1 1 Synthetic Lethality
DID4 YKL002W Class E Vps protein of the ESCRT-III complex physical 1 1 1 Affinity Capture-MS
CSM1 YCR086W Nucleolar protein that mediates homolog segregation during meiosis I genetic 1 1 1 Synthetic Lethality
VAM3 YOR106W Syntaxin-like vacuolar t-SNARE physical 1 1 1 Affinity Capture-MS
PEP12 YOR036W Target membrane receptor (t-SNARE) physical 1 1 1 Affinity Capture-MS
BOS1 YLR078C v-SNARE (vesicle specific SNAP receptor) physical 1 1 1 Affinity Capture-MS
CTF8 YHR191C Subunit of a complex with Ctf18p genetic 1 1 1 Synthetic Growth Defect
NYV1 YLR093C v-SNARE component of the vacuolar SNARE complex physical 1 1 1 Affinity Capture-MS
BET1 YIL004C Type II membrane protein required for vesicular transport physical 1 1 1 Affinity Capture-MS
SED5 YLR026C cis-Golgi t-SNARE syntaxin physical 1 1 1 Affinity Capture-MS
ERV41 YML067C Protein localized to COPII-coated vesicles physical 1 1 1 Affinity Capture-MS
SEC22 YLR268W R-SNARE protein physical 1 1 1 Affinity Capture-MS
SNC1 YAL030W Vesicle membrane receptor protein (v-SNARE) genetic 1 1 1 Synthetic Lethality
SNC2 YOR327C Vesicle membrane receptor protein (v-SNARE) genetic 1 1 1 Synthetic Lethality
PEP7 YDR323C Adaptor protein involved in vesicle-mediated vacuolar protein sorting genetic 1 1 1 Phenotypic Suppression
GOS1 YHL031C v-SNARE protein involved in Golgi transport physical 1 1 1 Affinity Capture-MS
SSO1 YPL232W Plasma membrane t-SNARE physical 1 1 1 Affinity Capture-MS
EMP47 YFL048C Integral membrane component of ER-derived COPII-coated vesicles physical 1 1 1 Affinity Capture-MS
PRM8 YGL053W Pheromone-regulated protein physical 1 1 1 Affinity Capture-MS
POL32 YJR043C Third subunit of DNA polymerase delta genetic 1 1 1 Synthetic Growth Defect
SLA2 YNL243W Adaptor protein that links actin to clathrin and endocytosis genetic 1 1 1 Synthetic Lethality
SFT1 YKL006C-A Intra-Golgi v-SNARE physical 1 1 1 Affinity Capture-MS
AKR1 YDR264C Palmitoyl transferase involved in protein palmitoylation physical 1 1 1 Affinity Capture-MS
LRS4 YDR439W Nucleolar protein that forms a complex with Csm1p genetic 1 1 1 Synthetic Growth Defect
TOR1 YJR066W PIK-related protein kinase and rapamycin target genetic 1 1 1 Synthetic Growth Defect
YIP1 YGR172C Integral membrane protein physical 1 1 1 Affinity Capture-MS
YPT32 YGL210W Rab family GTPase involved in the exocytic pathway physical 1 1 1 Affinity Capture-MS
YCK1 YHR135C Palmitoylated plasma membrane-bound casein kinase I (CK1) isoform physical 1 1 1 Affinity Capture-MS
YIF1 YNL263C Integral membrane protein physical 1 1 1 Affinity Capture-MS
YOP1 YPR028W Reticulon-interacting protein physical 1 1 1 Affinity Capture-MS
YPT52 YKR014C Endosomal Rab family GTPase physical 1 1 1 Affinity Capture-MS
YCK3 YER123W Palmitoylated vacuolar membrane-localized casein kinase I isoform physical 1 1 1 Affinity Capture-MS
YPT7 YML001W Rab family GTPase physical 1 1 1 Affinity Capture-MS
YIP3 YNL044W Protein localized to COPII vesicles physical 1 1 1 Affinity Capture-MS
YPT1 YFL038C Rab family GTPase physical 1 1 1 Affinity Capture-MS
YPT31 YER031C Rab family GTPase physical 1 1 1 Affinity Capture-MS
VTI1 YMR197C Protein involved in cis-Golgi membrane traffic physical 1 1 1 Affinity Capture-MS
VPS34 YLR240W Phosphatidylinositol (PI) 3-kinase that synthesizes PI-3-phosphate physical 1 1 1 Affinity Capture-MS
XRS2 YDR369C FHA domain-containing component of the Mre11 complex genetic 1 1 1 Synthetic Growth Defect
YPC1 YBR183W Alkaline ceramidase genetic 1 1 1 Negative Genetic
VPS15 YBR097W Serine/threonine protein kinase involved in vacuolar protein sorting genetic 1 1 1 Dosage Rescue
DID2 YKR035W-A Class E protein of the vacuolar protein-sorting (Vps) pathway physical 1 1 1 Affinity Capture-MS
STV1 YMR054W Subunit a of the vacuolar-ATPase V0 domain physical 1 1 1 Affinity Capture-MS
RPN4 YDL020C Transcription factor that stimulates expression of proteasome genes genetic 1 1 1 Synthetic Growth Defect
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
COY1 YKL179C Golgi membrane protein with similarity to mammalian CASP physical 1 1 1 Affinity Capture-MS
STH1 YIL126W ATPase component of the RSC chromatin remodeling complex genetic 1 1 1 Synthetic Growth Defect
SRS2 YJL092W DNA helicase and DNA-dependent ATPase genetic 1 1 1 Synthetic Growth Defect
DCC1 YCL016C Subunit of a complex with Ctf8p and Ctf18p genetic 1 1 1 Synthetic Growth Defect
TSA1 YML028W Thioredoxin peroxidase genetic 1 1 1 Synthetic Lethality
PMR1 YGL167C High affinity Ca2+/Mn2+ P-type ATPase physical 1 1 1 Affinity Capture-MS
RAD27 YKL113C 5' to 3' exonuclease, 5' flap endonuclease genetic 1 1 1 Synthetic Growth Defect
SAC1 YKL212W Phosphatidylinositol phosphate phosphatase genetic 1 1 1 Synthetic Lethality
SLX4 YLR135W Endonuclease involved in processing DNA genetic 1 1 1 Synthetic Growth Defect
SDS24 YBR214W Protein involved in cell separation during budding physical 1 1 1 Affinity Capture-MS
RAD57 YDR004W Protein that stimulates strand exchange genetic 1 1 1 Synthetic Growth Defect
SVP26 YHR181W ER exit adaptor for Golgi mannosyltransferases physical 1 1 1 Affinity Capture-MS
RCR2 YDR003W Vacuolar ubiquitin ligase-substrate adaptor physical 1 1 1 Affinity Capture-MS
PCS60 YBR222C Oxalyl-CoA synthetase physical 1 1 1 Co-fractionation
SFT2 YBL102W Tetra-spanning membrane protein found mostly in the late Golgi physical 1 1 1 Affinity Capture-MS
NEO1 YIL048W Phospholipid translocase (flippase) physical 1 1 1 Affinity Capture-MS
LGE1 YPL055C Protein involved in histone H2B ubiquitination genetic 1 1 1 Synthetic Lethality
SIC1 YLR079W Cyclin-dependent kinase inhibitor (CKI) genetic 1 1 1 Synthetic Lethality
VPS24 YKL041W One of four subunits of the ESCRT-III complex physical 1 1 1 Affinity Capture-MS
SSP120 YLR250W Protein packaged into COPII vesicles for ER to Golgi trafficking physical 1 1 1 Affinity Capture-MS
TVP38 YKR088C Integral membrane protein physical 1 1 1 Affinity Capture-MS