| RAD52 |
YML032C |
Protein involved in homologous recombination |
genetic |
19 |
6 |
18 |
Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Lethality, Dosage Rescue, Synthetic Growth Defect, Phenotypic Suppression, Synthetic Lethality, Negative Genetic, Phenotypic Suppression, Phenotypic Enhancement, Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect |
| EXO1 |
YOR033C |
5'-3' exonuclease and flap-endonuclease |
genetic |
17 |
4 |
15 |
Synthetic Rescue, Synthetic Rescue, Phenotypic Suppression, Phenotypic Suppression, Synthetic Lethality, Phenotypic Suppression, Synthetic Rescue, Phenotypic Suppression, Phenotypic Suppression, Synthetic Growth Defect, Synthetic Rescue, Phenotypic Suppression, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Phenotypic Suppression, Phenotypic Suppression |
| MRE11 |
YMR224C |
Nuclease subunit of the MRX complex with Rad50p and Xrs2p |
genetic |
17 |
5 |
12 |
Synthetic Rescue, Phenotypic Suppression, Synthetic Rescue, Dosage Growth Defect, Phenotypic Suppression, Phenotypic Suppression, Synthetic Rescue, Phenotypic Suppression, Phenotypic Suppression, Phenotypic Enhancement, Phenotypic Suppression, Phenotypic Suppression, Synthetic Rescue, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Rescue |
| EST1 |
YLR233C |
TLC1 RNA-associated factor involved in telomere length regulation |
genetic |
14 |
6 |
12 |
Dosage Rescue, Dosage Rescue, Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Synthetic Lethality, Synthetic Rescue, Synthetic Growth Defect, Negative Genetic, Phenotypic Suppression, Negative Genetic, Negative Genetic |
| YKU80 |
YMR106C |
Subunit of telomeric Ku complex (Yku70p-Yku80p) |
physical |
14 |
4 |
11 |
Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Co-crystal Structure, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western, Co-crystal Structure |
| PIF1 |
YML061C |
DNA helicase, potent G-quadruplex DNA binder/unwinder |
genetic |
13 |
7 |
10 |
Phenotypic Enhancement, Dosage Lethality, Dosage Lethality, Synthetic Rescue, Synthetic Rescue, Phenotypic Suppression, Synthetic Growth Defect, Phenotypic Enhancement, Dosage Growth Defect, Synthetic Lethality, Synthetic Rescue, Phenotypic Suppression, Synthetic Rescue |
| TEL1 |
YBL088C |
Protein kinase primarily involved in telomere length regulation |
genetic |
11 |
6 |
9 |
Synthetic Lethality, Phenotypic Enhancement, Phenotypic Enhancement, Negative Genetic, Phenotypic Suppression, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Rescue, Synthetic Growth Defect, Synthetic Rescue, Synthetic Growth Defect |
| SGS1 |
YMR190C |
RecQ family nucleolar DNA helicase |
genetic |
10 |
6 |
8 |
Synthetic Lethality, Dosage Rescue, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Rescue, Synthetic Growth Defect, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Phenotypic Suppression |
| SAE2 |
YGL175C |
Endonuclease required for telomere elongation |
genetic |
10 |
4 |
8 |
Synthetic Rescue, Dosage Growth Defect, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Growth Defect, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Phenotypic Enhancement |
| RAD50 |
YNL250W |
Subunit of MRX complex with Mre11p and Xrs2p |
genetic |
9 |
3 |
8 |
Synthetic Rescue, Phenotypic Suppression, Phenotypic Enhancement, Synthetic Rescue, Phenotypic Suppression, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Suppression, Synthetic Rescue |
| CDC13 |
YDL220C |
Single stranded DNA-binding protein found at TG1-3 telomere G-tails |
genetic |
8 |
4 |
8 |
Phenotypic Enhancement, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect, Synthetic Lethality, Phenotypic Suppression, Phenotypic Suppression |
| EST2 |
YLR318W |
Reverse transcriptase subunit of the telomerase holoenzyme |
genetic |
7 |
4 |
6 |
Dosage Rescue, Dosage Rescue, Synthetic Lethality, Synthetic Rescue, Phenotypic Suppression, Phenotypic Suppression, Synthetic Lethality |
| RIF1 |
YBR275C |
Protein involved in control of DNA replication |
genetic |
6 |
4 |
6 |
Phenotypic Enhancement, Phenotypic Suppression, Synthetic Rescue, Phenotypic Suppression, Synthetic Growth Defect, Synthetic Rescue |
| RAD9 |
YDR217C |
DNA damage-dependent checkpoint protein |
genetic |
6 |
3 |
6 |
Synthetic Rescue, Synthetic Rescue, Phenotypic Enhancement, Synthetic Rescue, Synthetic Growth Defect, Synthetic Rescue |
| RAD51 |
YER095W |
Strand exchange protein |
genetic |
6 |
4 |
5 |
Synthetic Lethality, Synthetic Rescue, Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect |
| CHK1 |
YBR274W |
Serine/threonine kinase and DNA damage checkpoint effector |
genetic |
5 |
1 |
5 |
Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue |
| SIR4 |
YDR227W |
SIR protein involved in assembly of silent chromatin domains |
physical |
5 |
2 |
4 |
Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Affinity Capture-Western |
| RIF2 |
YLR453C |
Protein that binds to the Rap1p C-terminus |
genetic |
4 |
3 |
4 |
Phenotypic Enhancement, Phenotypic Suppression, Phenotypic Suppression, Synthetic Rescue |
| RAD53 |
YPL153C |
DNA damage response kinase |
genetic |
4 |
3 |
3 |
Synthetic Rescue, Phenotypic Suppression, Synthetic Growth Defect, Synthetic Rescue |
| XRS2 |
YDR369C |
FHA domain-containing component of the Mre11 complex |
genetic |
4 |
3 |
3 |
Phenotypic Enhancement, Phenotypic Suppression, Negative Genetic, Phenotypic Suppression |
| EST3 |
YIL009C-A |
Component of the telomerase holoenzyme |
genetic |
4 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| PIN4 |
YBL051C |
Protein involved in G2/M phase progression and response to DNA damage |
genetic |
3 |
3 |
3 |
Phenotypic Enhancement, Synthetic Growth Defect, Negative Genetic |
| YNG2 |
YHR090C |
Subunit of NuA4, an essential histone acetyltransferase complex |
genetic |
3 |
3 |
3 |
Synthetic Lethality, Negative Genetic, Positive Genetic |
| SIR4 |
YDR227W |
SIR protein involved in assembly of silent chromatin domains |
genetic |
3 |
3 |
3 |
Phenotypic Suppression, Synthetic Growth Defect, Phenotypic Enhancement |
| REV3 |
YPL167C |
Catalytic subunit of DNA polymerase zeta |
genetic |
3 |
3 |
3 |
Phenotypic Suppression, Phenotypic Enhancement, Synthetic Growth Defect |
| CDC73 |
YLR418C |
Component of the Paf1p complex |
genetic |
3 |
2 |
3 |
Negative Genetic, Negative Genetic, Phenotypic Enhancement |
| DNA2 |
YHR164C |
ATP-dependent 5'-flap endonuclease and DNA helicase |
genetic |
3 |
2 |
3 |
Phenotypic Suppression, Synthetic Rescue, Phenotypic Suppression |
| MRC1 |
YCL061C |
S-phase checkpoint protein required for DNA replication |
genetic |
3 |
2 |
3 |
Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic |
| MEC1 |
YBR136W |
Genome integrity checkpoint protein and PI kinase superfamily member |
genetic |
3 |
1 |
3 |
Synthetic Rescue, Synthetic Rescue, Synthetic Rescue |
| RAD27 |
YKL113C |
5' to 3' exonuclease, 5' flap endonuclease |
genetic |
3 |
1 |
3 |
Synthetic Rescue, Synthetic Rescue, Synthetic Rescue |
| HUR1 |
YGL168W |
Protein with a role in DNA repair |
genetic |
3 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic |
| RTT103 |
YDR289C |
Protein involved in transcription termination by RNA polymerase II |
genetic |
3 |
3 |
2 |
Dosage Rescue, Synthetic Growth Defect, Negative Genetic |
| PPH3 |
YDR075W |
Catalytic subunit of protein phosphatase PP4 complex |
genetic |
3 |
2 |
2 |
Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect |
| NMD2 |
YHR077C |
Protein involved in the nonsense-mediated mRNA decay (NMD) pathway |
genetic |
3 |
2 |
2 |
Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect |
| OCA2 |
YNL056W |
Protein of unknown function |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| RFA1 |
YAR007C |
Subunit of heterotrimeric Replication Protein A (RPA) |
genetic |
2 |
2 |
2 |
Synthetic Rescue, Phenotypic Suppression |
| YKU80 |
YMR106C |
Subunit of telomeric Ku complex (Yku70p-Yku80p) |
genetic |
2 |
2 |
2 |
Dosage Lethality, Phenotypic Enhancement |
| RAD55 |
YDR076W |
Protein that stimulates strand exchange |
genetic |
2 |
2 |
2 |
Synthetic Rescue, Negative Genetic |
| CLB2 |
YPR119W |
B-type cyclin involved in cell cycle progression |
genetic |
2 |
2 |
2 |
Phenotypic Enhancement, Negative Genetic |
| ELG1 |
YOR144C |
Subunit of an alternative replication factor C complex |
genetic |
2 |
2 |
2 |
Phenotypic Suppression, Synthetic Rescue |
| SSN8 |
YNL025C |
Cyclin-like component of RNA polymerase II holoenzyme |
genetic |
2 |
2 |
2 |
Negative Genetic, Positive Genetic |
| LIF1 |
YGL090W |
Component of the DNA ligase IV complex |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Phenotypic Suppression |
| POL4 |
YCR014C |
DNA polymerase IV |
genetic |
2 |
2 |
2 |
Synthetic Rescue, Phenotypic Suppression |
| SAC1 |
YKL212W |
Phosphatidylinositol phosphate phosphatase |
genetic |
2 |
2 |
2 |
Negative Genetic, Synthetic Growth Defect |
| RTT109 |
YLL002W |
Histone acetyltransferase |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Synthetic Rescue |
| SUB1 |
YMR039C |
Transcriptional regulator |
genetic |
2 |
2 |
2 |
Negative Genetic, Phenotypic Suppression |
| SUM1 |
YDR310C |
Transcriptional repressor that regulates middle-sporulation genes |
genetic |
2 |
2 |
2 |
Negative Genetic, Synthetic Growth Defect |
| SIC1 |
YLR079W |
Cyclin-dependent kinase inhibitor (CKI) |
genetic |
2 |
2 |
2 |
Phenotypic Suppression, Positive Genetic |
| VPS74 |
YDR372C |
Golgi PI4K effector, PtdIns4P sensor, and retention receptor |
genetic |
2 |
2 |
2 |
Negative Genetic, Synthetic Growth Defect |
| TGS1 |
YPL157W |
Trimethyl guanosine synthase, conserved nucleolar methyl transferase |
genetic |
2 |
2 |
2 |
Negative Genetic, Phenotypic Suppression |
| HHF1 |
YBR009C |
Histone H4 |
physical |
2 |
1 |
2 |
Affinity Capture-MS, Affinity Capture-MS |
| HTA2 |
YBL003C |
Histone H2A |
physical |
2 |
1 |
2 |
Affinity Capture-MS, Affinity Capture-MS |
| MET18 |
YIL128W |
Component of cytosolic iron-sulfur protein assembly (CIA) machinery |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| PHO23 |
YNL097C |
Component of the Rpd3L histone deacetylase complex |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| SIR2 |
YDL042C |
Conserved NAD+ dependent histone deacetylase of the Sirtuin family |
genetic |
2 |
1 |
2 |
Synthetic Growth Defect, Synthetic Growth Defect |
| RAD1 |
YPL022W |
Single-stranded DNA endonuclease (with Rad10p) |
genetic |
2 |
1 |
2 |
Phenotypic Enhancement, Phenotypic Enhancement |
| HTB1 |
YDR224C |
Histone H2B |
physical |
2 |
1 |
2 |
Affinity Capture-MS, Affinity Capture-MS |
| RVS167 |
YDR388W |
Calmodulin-binding actin-associated protein |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| HHT1 |
YBR010W |
Histone H3 |
physical |
2 |
1 |
2 |
Affinity Capture-MS, Affinity Capture-MS |
| SPT3 |
YDR392W |
Subunit of the SAGA and SAGA-like transcriptional regulatory complexes |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| ESC1 |
YMR219W |
Protein involved in telomeric silencing |
genetic |
2 |
1 |
2 |
Phenotypic Enhancement, Phenotypic Enhancement |
| RAD57 |
YDR004W |
Protein that stimulates strand exchange |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| BRE1 |
YDL074C |
E3 ubiquitin ligase |
genetic |
2 |
2 |
1 |
Synthetic Growth Defect, Phenotypic Enhancement |
| NAM7 |
YMR080C |
ATP-dependent RNA helicase of the SFI superfamily |
genetic |
2 |
2 |
1 |
Synthetic Growth Defect, Negative Genetic |
| BIR1 |
YJR089W |
Subunit of chromosomal passenger complex (CPC) |
genetic |
2 |
2 |
1 |
Synthetic Growth Defect, Negative Genetic |
| ELP6 |
YMR312W |
Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex |
genetic |
2 |
2 |
1 |
Synthetic Rescue, Negative Genetic |
| RRD1 |
YIL153W |
Peptidyl-prolyl cis/trans-isomerase |
genetic |
2 |
2 |
1 |
Synthetic Growth Defect, Negative Genetic |
| STN1 |
YDR082W |
Telomere end-binding and capping protein |
genetic |
2 |
2 |
1 |
Dosage Growth Defect, Dosage Rescue |
| RAD4 |
YER162C |
Damaged-DNA binding subunit of Nuclear Excision Repair Factor 2 |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| PMR1 |
YGL167C |
High affinity Ca2+/Mn2+ P-type ATPase |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| NEJ1 |
YLR265C |
DNA end-binding protein required for nonhomologous end joining (NHEJ) |
physical |
2 |
1 |
1 |
Affinity Capture-Western, Affinity Capture-Western |
| SPE1 |
YKL184W |
Ornithine decarboxylase |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| FKH1 |
YIL131C |
Forkhead family transcription factor |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| RFX1 |
YLR176C |
Major transcriptional repressor of DNA-damage-regulated genes |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| YAP1 |
YML007W |
Basic leucine zipper (bZIP) transcription factor |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| TFC7 |
YOR110W |
RNA pol III transcription initiation factor complex (TFIIIC) subunit |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| SPT3 |
YDR392W |
Subunit of the SAGA and SAGA-like transcriptional regulatory complexes |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| GCN4 |
YEL009C |
bZIP transcriptional activator of amino acid biosynthetic genes |
regulation |
1 |
1 |
1 |
DNA to cDNA expression microarray evidence |
| SPT6 |
YGR116W |
Nucleosome remodeling protein |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| INO2 |
YDR123C |
Transcription factor |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| PHO2 |
YDL106C |
Homeobox transcription factor |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| LEO1 |
YOR123C |
Component of the Paf1 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RTF1 |
YGL244W |
Subunit of RNAPII-associated chromatin remodeling Paf1 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TAF14 |
YPL129W |
Subunit of TFIID, TFIIF, INO80, SWI/SNF, and NuA3 complexes |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MMS21 |
YEL019C |
Highly conserved SUMO E3 ligase subunit of SMC5-SMC6 complex |
physical |
1 |
1 |
1 |
Biochemical Activity |
| RVB1 |
YDR190C |
ATP-dependent DNA helicase, also known as pontin |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| RVB1 |
YDR190C |
ATP-dependent DNA helicase, also known as pontin |
genetic |
1 |
1 |
1 |
Positive Genetic |
| EAF1 |
YDR359C |
Component of the NuA4 histone acetyltransferase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ADH1 |
YOL086C |
Alcohol dehydrogenase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PEX19 |
YDL065C |
Chaperone and import receptor for newly-synthesized class I PMPs |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| POL5 |
YEL055C |
Protein involved in 60S assembly and pre-40S AFs recycling |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SAP155 |
YFR040W |
Protein required for function of the Sit4p protein phosphatase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TMA64 |
YDR117C |
Protein of unknown function that associates with ribosomes |
genetic |
1 |
1 |
1 |
Positive Genetic |
| NPL3 |
YDR432W |
RNA-binding protein |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| RPA34 |
YJL148W |
RNA polymerase I subunit A34.5 |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RET1 |
YOR207C |
Second-largest subunit of RNA polymerase III |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| RPC25 |
YKL144C |
RNA polymerase III subunit C25 |
genetic |
1 |
1 |
1 |
Positive Genetic |
| RSC2 |
YLR357W |
Component of the RSC chromatin remodeling complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| DST1 |
YGL043W |
General transcription elongation factor TFIIS |
genetic |
1 |
1 |
1 |
Negative Genetic |
| REI1 |
YBR267W |
Cytoplasmic pre-60S factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPN10 |
YHR200W |
Proteasome polyubiquitin receptor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPT3 |
YDR394W |
ATPase of the 19S regulatory particle of the 26S proteasome |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| UBP6 |
YFR010W |
Ubiquitin-specific protease |
genetic |
1 |
1 |
1 |
Negative Genetic |
| REB1 |
YBR049C |
RNA polymerase I enhancer binding protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TRM1 |
YDR120C |
tRNA methyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| OLA1 |
YBR025C |
P-loop ATPase with similarity to human OLA1 and bacterial YchF |
genetic |
1 |
1 |
1 |
Negative Genetic |
| BOI2 |
YER114C |
Protein involved in polar growth |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| CDC28 |
YBR160W |
Cyclin-dependent kinase (CDK) catalytic subunit |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| CDC45 |
YLR103C |
DNA replication initiation factor |
genetic |
1 |
1 |
1 |
Dosage Rescue |
| DOA1 |
YKL213C |
WD-repeat protein involved in ubiquitin-mediated protein degradation |
genetic |
1 |
1 |
1 |
Negative Genetic |
| EDE1 |
YBL047C |
Scaffold protein involved in the formation of early endocytic sites |
genetic |
1 |
1 |
1 |
Negative Genetic |
| FTH1 |
YBR207W |
Putative high affinity iron transporter |
genetic |
1 |
1 |
1 |
Negative Genetic |
| HHF1 |
YBR009C |
Histone H4 |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| DHH1 |
YDL160C |
Cytoplasmic DEAD-box helicase and mRNA decapping activator |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| HHF2 |
YNL030W |
Histone H4 |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| HHF2 |
YNL030W |
Histone H4 |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| HSM3 |
YBR272C |
Evolutionarily conserved 19S regulatory particle assembly-chaperone |
genetic |
1 |
1 |
1 |
Negative Genetic |
| HST1 |
YOL068C |
NAD(+)-dependent histone deacetylase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| HTB2 |
YBL002W |
Histone H2B |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| ISW1 |
YBR245C |
ATPase subunit of imitation-switch (ISWI) class chromatin remodelers |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| ISW2 |
YOR304W |
ATP-dependent DNA translocase involved in chromatin remodeling |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| MCD1 |
YDL003W |
Essential alpha-kleisin subunit of the cohesin complex |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| HSC82 |
YMR186W |
Cytoplasmic chaperone of the Hsp90 family |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| IMG2 |
YCR071C |
Mitochondrial ribosomal protein of the large subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MPH1 |
YIR002C |
3'-5' DNA helicase involved in error-free bypass of DNA lesions |
genetic |
1 |
1 |
1 |
Dosage Lethality |
| CMR1 |
YDL156W |
Nuclear protein with role in transcription, protein quality control |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| MUM2 |
YBR057C |
Protein essential for meiotic DNA replication and sporulation |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NHP10 |
YDL002C |
Non-essential INO80 chromatin remodeling complex subunit |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| NHP6B |
YBR089C-A |
High-mobility group (HMG) protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| FPR4 |
YLR449W |
Peptidyl-prolyl cis-trans isomerase (PPIase) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| LPD1 |
YFL018C |
Dihydrolipoamide dehydrogenase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| HSP82 |
YPL240C |
Hsp90 chaperone |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| HTA1 |
YDR225W |
Histone H2A |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| HTA1 |
YDR225W |
Histone H2A |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| POL2 |
YNL262W |
Catalytic subunit of DNA polymerase (II) epsilon |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| RAD16 |
YBR114W |
Nucleotide excision repair (NER) protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RFC5 |
YBR087W |
Subunit of heteropentameric Replication factor C (RF-C) |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| RNA14 |
YMR061W |
Component of the cleavage and polyadenylation factor I (CF I) |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| PGD1 |
YGL025C |
Subunit of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPB10 |
YOR210W |
RNA polymerase subunit ABC10-beta |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SIF2 |
YBR103W |
WD40 repeat-containing subunit of Set3C histone deacetylase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SAP30 |
YMR263W |
Component of Rpd3L histone deacetylase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SDS3 |
YIL084C |
Component of the Rpd3L histone deacetylase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SIN3 |
YOL004W |
Component of both the Rpd3S and Rpd3L histone deacetylase complexes |
genetic |
1 |
1 |
1 |
Negative Genetic |
| BGL2 |
YGR282C |
Endo-beta-1,3-glucanase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| INP52 |
YNL106C |
Polyphosphatidylinositol phosphatase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| BRR1 |
YPR057W |
snRNP protein component of spliceosomal snRNPs |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SNF1 |
YDR477W |
AMP-activated S/T protein kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SNF5 |
YBR289W |
Subunit of the SWI/SNF chromatin remodeling complex |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| SGF73 |
YGL066W |
Subunit of DUBm module of SAGA and SLIK |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MLP1 |
YKR095W |
Myosin-like protein associated with the nuclear envelope |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| CRN1 |
YLR429W |
Coronin |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TAF13 |
YML098W |
TFIID subunit (19 kDa) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SPT8 |
YLR055C |
Subunit of the SAGA transcriptional regulatory complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ECM30 |
YLR436C |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| VPS29 |
YHR012W |
Subunit of the membrane-associated retromer complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| VAM6 |
YDL077C |
Guanine nucleotide exchange factor for the GTPase Gtr1p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| VRP1 |
YLR337C |
Verprolin, proline-rich actin-associated protein |
genetic |
1 |
1 |
1 |
Positive Genetic |
| RAD10 |
YML095C |
Single-stranded DNA endonuclease (with Rad1p) |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| DRS2 |
YAL026C |
Trans-golgi network aminophospholipid translocase (flippase) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| BRE2 |
YLR015W |
Subunit of COMPASS (Set1C) complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SDC1 |
YDR469W |
Subunit of the COMPASS (Set1C) complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SPP1 |
YPL138C |
Subunit of COMPASS (Set1C) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| BOI1 |
YBL085W |
Protein involved in polar growth, functionally redundant with Boi2p |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| YPL191C |
YPL191C |
K48-specific deubiquitinating (DUB) enzyme |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YTA6 |
YPL074W |
Putative ATPase of the CDC48/PAS1/SEC18 (AAA) family |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YPR089W |
YPR089W |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YPK9 |
YOR291W |
Vacuolar protein with a possible role in sequestering heavy metals |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YPT7 |
YML001W |
Rab family GTPase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YLH47 |
YPR125W |
Mitochondrial inner membrane protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YMD8 |
YML038C |
Putative nucleotide sugar transporter |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SNT1 |
YCR033W |
Set3C histone deacetylase scaffold |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ATP4 |
YPL078C |
Subunit b of the stator stalk of mitochondrial F1F0 ATP synthase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| AKL1 |
YBR059C |
Ser/Thr protein kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| IRA2 |
YOL081W |
GTPase-activating protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| HYP2 |
YEL034W |
Translation elongation factor eIF-5A |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| STI1 |
YOR027W |
Evolutionarily-conserved Hsp90 cochaperone |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RAD54 |
YGL163C |
DNA-dependent ATPase that stimulates strand exchange |
genetic |
1 |
1 |
1 |
Negative Genetic |
| HTB1 |
YDR224C |
Histone H2B |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| GET1 |
YGL020C |
Subunit of the GET complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| GET2 |
YER083C |
Subunit of the GET complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TOP2 |
YNL088W |
Topoisomerase II |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| TPS2 |
YDR074W |
Phosphatase subunit of the trehalose-6-P synthase/phosphatase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YHR033W |
YHR033W |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| FUM1 |
YPL262W |
Fumarase |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| KAP122 |
YGL016W |
Karyopherin beta |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MOH1 |
YBL049W |
Protein of unknown function, essential for stationary phase survival |
genetic |
1 |
1 |
1 |
Negative Genetic |
| UFD2 |
YDL190C |
Ubiquitin (Ub) chain assembly factor (E4) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| OCA1 |
YNL099C |
Putative protein tyrosine phosphatase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| EST1 |
YLR233C |
TLC1 RNA-associated factor involved in telomere length regulation |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| RAD6 |
YGL058W |
Ubiquitin-conjugating enzyme (E2) |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| FRS2 |
YFL022C |
Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| DNL4 |
YOR005C |
DNA ligase required for nonhomologous end-joining (NHEJ) |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| MCX1 |
YBR227C |
Non-proteolytic ATPase of the AAA family |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RAD24 |
YER173W |
Checkpoint protein |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| CAC2 |
YML102W |
Subunit of chromatin assembly factor I (CAF-1), with Rlf2p and Msi1p |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| CWC21 |
YDR482C |
Protein involved in RNA splicing by the spliceosome |
genetic |
1 |
1 |
1 |
Negative Genetic |
| HHO1 |
YPL127C |
Histone H1, linker histone with roles in meiosis and sporulation |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| MEK1 |
YOR351C |
Meiosis-specific serine/threonine protein kinase |
genetic |
1 |
1 |
1 |
Positive Genetic |
| RCK1 |
YGL158W |
Protein kinase involved in oxidative stress response |
physical |
1 |
1 |
1 |
Biochemical Activity |
| RAD59 |
YDL059C |
Protein involved DNA double-strand break repair |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| NTG1 |
YAL015C |
DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| ECM33 |
YBR078W |
GPI-anchored protein involved in efficient glucose uptake |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NUP2 |
YLR335W |
Nucleoporin involved in nucleocytoplasmic transport |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SPT2 |
YER161C |
Protein involved in negative regulation of transcription |
genetic |
1 |
1 |
1 |
Negative Genetic |
| FKH2 |
YNL068C |
Forkhead family transcription factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MCK1 |
YNL307C |
Dual-specificity ser/thr and tyrosine protein kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| GDT1 |
YBR187W |
Calcium and manganese transporter with higher affinity for Ca2+ |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DBF2 |
YGR092W |
Ser/Thr kinase involved in transcription and stress response |
genetic |
1 |
1 |
1 |
Negative Genetic |
| FUS3 |
YBL016W |
Mitogen-activated serine/threonine protein kinase involved in mating |
genetic |
1 |
1 |
1 |
Positive Genetic |
| PRS5 |
YOL061W |
5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ADE6 |
YGR061C |
Formylglycinamidine-ribonucleotide (FGAM)-synthetase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| GCY1 |
YOR120W |
Glycerol dehydrogenase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PSO2 |
YMR137C |
Nuclease required for DNA single- and double-strand break repair |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| SNF4 |
YGL115W |
Activating gamma subunit of the AMP-activated Snf1p kinase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| FMP48 |
YGR052W |
Putative protein of unknown function |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| MLP2 |
YIL149C |
Myosin-like protein associated with the nuclear envelope |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
| MLP2 |
YIL149C |
Myosin-like protein associated with the nuclear envelope |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| SIR1 |
YKR101W |
Protein involved in silencing at mating-type loci HML and HMR |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| NBP2 |
YDR162C |
Protein involved in the HOG (high osmolarity glycerol) pathway |
genetic |
1 |
1 |
1 |
Negative Genetic |
| IME2 |
YJL106W |
Serine/threonine protein kinase involved in activation of meiosis |
physical |
1 |
1 |
1 |
Biochemical Activity |
| LAC1 |
YKL008C |
Ceramide synthase component |
genetic |
1 |
1 |
1 |
Positive Genetic |
| EBS1 |
YDR206W |
Protein involved in translation inhibition and nonsense-mediated decay |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| SMT3 |
YDR510W |
Ubiquitin-like protein of the SUMO family |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| MCM16 |
YPR046W |
Component of the Ctf19 complex and the COMA subcomplex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MAD2 |
YJL030W |
Component of the spindle-assembly checkpoint complex |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| RRN10 |
YBL025W |
Protein involved in promoting high level transcription of rDNA |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ACF4 |
YJR083C |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NTC20 |
YBR188C |
Member of the NineTeen Complex (NTC) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TOP1 |
YOL006C |
Topoisomerase I |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| VAM3 |
YOR106W |
Syntaxin-like vacuolar t-SNARE |
genetic |
1 |
1 |
1 |
Negative Genetic |
| VPS17 |
YOR132W |
Subunit of the membrane-associated retromer complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| KTI12 |
YKL110C |
Protein that plays a role in modification of tRNA wobble nucleosides |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YIF1 |
YNL263C |
Integral membrane protein |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| PRR1 |
YKL116C |
Serine/threonine protein kinase |
physical |
1 |
1 |
1 |
Biochemical Activity |
| AIM4 |
YBR194W |
Protein proposed to be associated with the nuclear pore complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SIW14 |
YNL032W |
Inositol phosphatase involved in inositol pyrophosphate metabolism |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ELP4 |
YPL101W |
Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPS4A |
YJR145C |
Protein component of the small (40S) ribosomal subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CST6 |
YIL036W |
Basic leucine zipper (bZIP) transcription factor from ATF/CREB family |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SAC3 |
YDR159W |
mRNA export factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ARP6 |
YLR085C |
Actin-related protein that binds nucleosomes |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SWR1 |
YDR334W |
Swi2/Snf2-related ATPase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SWC5 |
YBR231C |
Component of the SWR1 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DAL81 |
YIR023W |
Positive regulator of genes in multiple nitrogen degradation pathways |
genetic |
1 |
1 |
1 |
Negative Genetic |
| IES4 |
YOR189W |
Component of the INO80 chromatiin remodeling complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SNF6 |
YHL025W |
Subunit of the SWI/SNF chromatin remodeling complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RTG3 |
YBL103C |
bHLH/Zip transcription factor for retrograde (RTG) and TOR pathways |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPS11A |
YDR025W |
Protein component of the small (40S) ribosomal subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
| VPS71 |
YML041C |
Nucleosome-binding component of the SWR1 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| APN1 |
YKL114C |
Major apurinic/apyrimidinic endonuclease |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| ELO2 |
YCR034W |
Fatty acid elongase, involved in sphingolipid biosynthesis |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ATS1 |
YAL020C |
Protein required for modification of wobble nucleosides in tRNA |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NRG1 |
YDR043C |
Transcriptional repressor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RAD17 |
YOR368W |
Checkpoint protein |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| SAS2 |
YMR127C |
Histone acetyltransferase (HAT) catalytic subunit of the SAS complex |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| RAP1 |
YNL216W |
Essential DNA-binding transcription regulator that binds many loci |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| SSA1 |
YAL005C |
ATPase involved in protein folding and NLS-directed nuclear transport |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SWI4 |
YER111C |
DNA binding component of the SBF complex (Swi4p-Swi6p) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YAF9 |
YNL107W |
Subunit of NuA4 histone H4 acetyltransferase and SWR1 complexes |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DPH1 |
YIL103W |
Protein required for synthesis of diphthamide |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| VPS60 |
YDR486C |
Protein involved in late endosome to vacuole transport |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MPT5 |
YGL178W |
mRNA-binding protein of the PUF family |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| CSG2 |
YBR036C |
Endoplasmic reticulum membrane protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| GYP1 |
YOR070C |
Cis-golgi GTPase-activating protein (GAP) for yeast Rabs |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PPR1 |
YLR014C |
Zinc finger transcription factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| POL32 |
YJR043C |
Third subunit of DNA polymerase delta |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| STE50 |
YCL032W |
Adaptor protein for various signaling pathways |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SMI1 |
YGR229C |
Protein involved in the regulation of cell wall synthesis |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YJR084W |
YJR084W |
Protein that forms a complex with Thp3p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| GPB2 |
YAL056W |
Multistep regulator of cAMP-PKA signaling |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DOT1 |
YDR440W |
Nucleosomal histone H3-Lys79 methylase |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| HMT1 |
YBR034C |
Nuclear SAM-dependent mono- and asymmetric methyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MON1 |
YGL124C |
Subunit of a heterodimeric guanine nucleotide exchange factor (GEF) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CUS2 |
YNL286W |
Putative checkpoint factor in transcription |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ACF2 |
YLR144C |
Intracellular beta-1,3-endoglucanase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TOF2 |
YKR010C |
Protein required for rDNA silencing and mitotic rDNA condensation |
genetic |
1 |
1 |
1 |
Negative Genetic |
| HHT2 |
YNL031C |
Histone H3 |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| SWC3 |
YAL011W |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SUR1 |
YPL057C |
Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
| BSD2 |
YBR290W |
Heavy metal ion homeostasis protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| HOC1 |
YJR075W |
Alpha-1,6-mannosyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| VPS30 |
YPL120W |
Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II |
genetic |
1 |
1 |
1 |
Negative Genetic |
| VPS38 |
YLR360W |
Part of a Vps34p phosphatidylinositol 3-kinase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PMT2 |
YAL023C |
Protein O-mannosyltransferase of the ER membrane |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DID2 |
YKR035W-A |
Class E protein of the vacuolar protein-sorting (Vps) pathway |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPL11A |
YPR102C |
Ribosomal 60S subunit protein L11A |
genetic |
1 |
1 |
1 |
Positive Genetic |
| CLB3 |
YDL155W |
B-type cyclin involved in cell cycle progression |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SGF11 |
YPL047W |
Integral subunit of SAGA histone acetyltransferase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MOG1 |
YJR074W |
Conserved nuclear protein that interacts with GTP-Gsp1p |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| MOG1 |
YJR074W |
Conserved nuclear protein that interacts with GTP-Gsp1p |
genetic |
1 |
1 |
1 |
Positive Genetic |
| IXR1 |
YKL032C |
Transcriptional repressor that regulates hypoxic genes during normoxia |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SAC7 |
YDR389W |
GTPase activating protein (GAP) for Rho1p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPL16B |
YNL069C |
Ribosomal 60S subunit protein L16B |
genetic |
1 |
1 |
1 |
Negative Genetic |
| BTS1 |
YPL069C |
Geranylgeranyl diphosphate synthase (GGPPS) |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SRS2 |
YJL092W |
DNA helicase and DNA-dependent ATPase |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| RFA2 |
YNL312W |
Subunit of heterotrimeric Replication Protein A (RPA) |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| RPL40B |
YKR094C |
Ubiquitin-ribosomal 60S subunit protein L40B fusion protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| BPH1 |
YCR032W |
Protein homologous to Chediak-Higashi syndrome and Beige proteins |
genetic |
1 |
1 |
1 |
Negative Genetic |
| KCS1 |
YDR017C |
Inositol hexakisphosphate and inositol heptakisphosphate kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| UME6 |
YDR207C |
Rpd3L histone deacetylase complex subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TFC6 |
YDR362C |
Subunit of RNA polymerase III transcription initiation factor complex |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| RAD30 |
YDR419W |
DNA polymerase eta |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| JIP4 |
YDR475C |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Positive Genetic |
| UBP3 |
YER151C |
Ubiquitin-specific protease that cleaves Ub-protein fusions |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ATG32 |
YIL146C |
Mitochondrial outer membrane protein required to initiate mitophagy |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NEL1 |
YHR035W |
Activator of Sar1p GTPase activity |
genetic |
1 |
1 |
1 |
Positive Genetic |
| MPP6 |
YNR024W |
Nuclear exosome-associated RNA binding protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| IMP21 |
YIL154C |
Transcriptional activator involved in maintenance of ion homeostasis |
genetic |
1 |
1 |
1 |
Negative Genetic |
| OCA4 |
YCR095C |
Cytoplasmic protein required for replication of Brome mosaic virus |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ALD6 |
YPL061W |
Cytosolic aldehyde dehydrogenase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| FUN14 |
YAL008W |
Integral mitochondrial outer membrane (MOM) protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CGI121 |
YML036W |
Component of the EKC/KEOPS complex |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| SIS2 |
YKR072C |
Negative regulatory subunit of protein phosphatase 1 (Ppz1p) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SLX4 |
YLR135W |
Endonuclease involved in processing DNA |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| VAC14 |
YLR386W |
Enzyme regulator |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PSP2 |
YML017W |
Asn rich cytoplasmic protein that contains RGG motifs |
genetic |
1 |
1 |
1 |
Negative Genetic |
| AIM26 |
YKL037W |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| POC4 |
YPL144W |
Component of a heterodimeric Poc4p-Irc25p chaperone |
genetic |
1 |
1 |
1 |
Negative Genetic |
| FLO11 |
YIR019C |
GPI-anchored cell surface glycoprotein (flocculin) |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| RPL42A |
YNL162W |
Ribosomal 60S subunit protein L42A |
genetic |
1 |
1 |
1 |
Negative Genetic |
| IRC25 |
YLR021W |
Component of a heterodimeric Poc4p-Irc25p chaperone |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPS6A |
YPL090C |
Protein component of the small (40S) ribosomal subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SEA4 |
YBL104C |
Subunit of SEACAT, a subcomplex of the SEA complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPL17B |
YJL177W |
Ribosomal 60S subunit protein L17B |
genetic |
1 |
1 |
1 |
Negative Genetic |
| OCA5 |
YHL029C |
Cytoplasmic protein required for replication of Brome mosaic virus |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ULP1 |
YPL020C |
Protease that specifically cleaves Smt3p protein conjugates |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| UME1 |
YPL139C |
Component of both the Rpd3S and Rpd3L histone deacetylase complexes |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ATG21 |
YPL100W |
Phosphoinositide binding protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| HST4 |
YDR191W |
NAD(+)-dependent protein deacetylase |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| SKY1 |
YMR216C |
SR protein kinase (SRPK) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NEJ1 |
YLR265C |
DNA end-binding protein required for nonhomologous end joining (NHEJ) |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| SSF2 |
YDR312W |
Protein required for ribosomal large subunit maturation |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RTT106 |
YNL206C |
Histone chaperone |
genetic |
1 |
1 |
1 |
Negative Genetic |
| VHS3 |
YOR054C |
Negative regulatory subunit of protein phosphatase 1 Ppz1p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NCR1 |
YPL006W |
Vacuolar membrane protein involved with Npc2p in sterol trafficking |
genetic |
1 |
1 |
1 |
Negative Genetic |
| VPS5 |
YOR069W |
Nexin-1 homolog |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DCR2 |
YLR361C |
Protein phosphatase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| VTA1 |
YLR181C |
Multivesicular body (MVB) protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| EST2 |
YLR318W |
Reverse transcriptase subunit of the telomerase holoenzyme |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
| NTG2 |
YOL043C |
DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| MET7 |
YOR241W |
Folylpolyglutamate synthetase |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| SHE1 |
YBL031W |
Mitotic spindle protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SCS7 |
YMR272C |
Sphingolipid alpha-hydroxylase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ILM1 |
YJR118C |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| LGE1 |
YPL055C |
Protein involved in histone H2B ubiquitination |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ARO7 |
YPR060C |
Chorismate mutase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| VPS75 |
YNL246W |
NAP family histone chaperone |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| PEX22 |
YAL055W |
Putative peroxisomal membrane protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MAK31 |
YCR020C-A |
Non-catalytic subunit of N-terminal acetyltransferase of the NatC type |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| MSN1 |
YOL116W |
Transcriptional activator |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TEL2 |
YGR099W |
Subunit of the ASTRA complex, involved in chromatin remodeling |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| AVT5 |
YBL089W |
Putative transporter |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SPT21 |
YMR179W |
Protein with a role in transcriptional silencing |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RCE1 |
YMR274C |
Type II CAAX prenyl protease |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ICL2 |
YPR006C |
2-methylisocitrate lyase of the mitochondrial matrix |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPL21B |
YPL079W |
Ribosomal 60S subunit protein L21B |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ROT2 |
YBR229C |
Glucosidase II catalytic subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
| LAS21 |
YJL062W |
Mannose-ethanolamine phosphotransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MMM1 |
YLL006W |
ER integral membrane protein, ERMES complex subunit |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SLD3 |
YGL113W |
Protein involved in the initiation of DNA replication |
genetic |
1 |
1 |
1 |
Dosage Rescue |
| VPS9 |
YML097C |
Guanine nucleotide exchange factor (GEF) and ubiquitin receptor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ILT1 |
YDR090C |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RTT105 |
YER104W |
Chaperone for Replication Protein A complex (RPA) |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| EMP65 |
YER140W |
Integral membrane protein of the ER |
genetic |
1 |
1 |
1 |
Negative Genetic |
| LST4 |
YKL176C |
Subunit of the Lst4p-Lst7p GTPase activating protein complex for Gtr2p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| UBC13 |
YDR092W |
E2 ubiquitin-conjugating enzyme |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MME1 |
YMR166C |
Transporter of the mitochondrial inner membrane that exports magnesium |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RRM3 |
YHR031C |
DNA helicase involved in rDNA replication and Ty1 transposition |
genetic |
1 |
1 |
1 |
Negative Genetic |
| UPF3 |
YGR072W |
Component of the nonsense-mediated mRNA decay (NMD) pathway |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SRC1 |
YML034W |
Inner nuclear membrane protein |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| APQ12 |
YIL040W |
Nuclear envelope/ER integral membrane protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SPF1 |
YEL031W |
P-type ATPase, ion transporter of the ER membrane |
genetic |
1 |
1 |
1 |
Negative Genetic |
| UBP12 |
YJL197W |
Ubiquitin-specific protease |
genetic |
1 |
1 |
1 |
Negative Genetic |
| UGA3 |
YDL170W |
Transcriptional activator for GABA-dependent induction of GABA genes |
genetic |
1 |
1 |
1 |
Negative Genetic |
| VAM10 |
YOR068C |
Protein involved in vacuole morphogenesis |
genetic |
1 |
1 |
1 |
Negative Genetic |
| UMP1 |
YBR173C |
Chaperone required for correct maturation of the 20S proteasome |
genetic |
1 |
1 |
1 |
Negative Genetic |
| OCA6 |
YDR067C |
Cytoplasmic protein required for replication of Brome mosaic virus |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SUA5 |
YGL169W |
Protein involved in threonylcarbamoyl adenosine biosynthesis |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| YDL180W |
YDL180W |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YCL002C |
YCL002C |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YDL086W |
YDL086W |
Putative carboxymethylenebutenolidase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SLD7 |
YOR060C |
Protein with a role in chromosomal DNA replication |
genetic |
1 |
1 |
1 |
Dosage Rescue |
| YER187W |
YER187W |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Positive Genetic |
| ROF1 |
YHR177W |
Putative transcription factor containing a WOPR domain |
genetic |
1 |
1 |
1 |
Negative Genetic |
