Standard name Systematic name Name description Description
BNA2 YJR078W Tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase Tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase; required for de novo biosynthesis of NAD+ from tryptophan via kynurenine; up-regulated by telomere uncapping, and interacts genetically with capping gene CDC13; overexpression reduces lipid droplet accumulation by skewing glycolytic flux towards biosynthesis of shikimate, aromatic amino acids, and NAD+ during aging and extends lifespan; regulated by Hst1p and Aftp
Visualize the interactome of BNA2
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
no data no data no data

GFP localization & abundance

GFP localization GFP abundance
no data 149

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
BNA2 2 0 0 0 0

Enzyme information

Catalyzed reactions in Yeast8
r_0694 (L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing))

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
NPT1 YOR209C Nicotinate phosphoribosyltransferase genetic 5 2 4 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
TNA1 YGR260W High affinity nicotinic acid plasma membrane permease genetic 5 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SUM1 YDR310C Transcriptional repressor that regulates middle-sporulation genes regulation 2 2 2 chromatin immunoprecipitation-chip evidence, DNA to cDNA expression microarray evidence
TOK1 YJL093C Outward-rectifier potassium channel of the plasma membrane genetic 2 1 2 Negative Genetic, Negative Genetic
IMP2 YMR035W Catalytic subunit of mitochondrial inner membrane peptidase complex genetic 2 1 2 Negative Genetic, Negative Genetic
ALT2 YDR111C Catalytically inactive alanine transaminase genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
AGX1 YFL030W Alanine:glyoxylate aminotransferase (AGT) genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
DBP3 YGL078C RNA-Dependent ATPase, member of DExD/H-box family genetic 2 1 1 Negative Genetic, Negative Genetic
FKH1 YIL131C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SPT10 YJL127C Histone H3 acetylase with a role in transcriptional regulation regulation 1 1 1 DNA to cDNA expression microarray evidence
FKH2 YNL068C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
XBP1 YIL101C Transcriptional repressor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
TFC7 YOR110W RNA pol III transcription initiation factor complex (TFIIIC) subunit regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SIR2 YDL042C Conserved NAD+ dependent histone deacetylase of the Sirtuin family regulation 1 1 1 RNA-sequencing evidence
SIR3 YLR442C Silencing protein regulation 1 1 1 RNA-sequencing evidence
SIR4 YDR227W SIR protein involved in assembly of silent chromatin domains regulation 1 1 1 RNA-sequencing evidence
HCM1 YCR065W Forkhead transcription factor regulation 1 1 1 quantitative polymerase chain reaction evidence
ARO1 YDR127W Pentafunctional arom protein genetic 1 1 1 Phenotypic Suppression
ADE3 YGR204W Cytoplasmic trifunctional enzyme genetic 1 1 1 Phenotypic Enhancement
BNA1 YJR025C 3-hydroxyanthranilic acid dioxygenase genetic 1 1 1 Phenotypic Suppression
SPS1 YDR523C STE20-family GCKIII protein kinase physical 1 1 1 Biochemical Activity
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit physical 1 1 1 Affinity Capture-MS
RPS1A YLR441C Ribosomal protein of the small (40S) subunit physical 1 1 1 Affinity Capture-MS
RPS2 YGL123W Protein component of the small (40S) subunit physical 1 1 1 Affinity Capture-MS
RPS8A YBL072C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS9A YPL081W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPL26A YLR344W Ribosomal 60S subunit protein L26A physical 1 1 1 Affinity Capture-MS
RPS27A YKL156W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS14A YCR031C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
CDC13 YDL220C Single stranded DNA-binding protein found at TG1-3 telomere G-tails genetic 1 1 1 Synthetic Rescue
GAP1 YKR039W General amino acid permease genetic 1 1 1 Synthetic Lethality
LYP1 YNL268W Lysine permease genetic 1 1 1 Synthetic Lethality
LYS12 YIL094C Homo-isocitrate dehydrogenase genetic 1 1 1 Synthetic Lethality
LYS20 YDL182W Homocitrate synthase isozyme and functions in DNA repair genetic 1 1 1 Synthetic Lethality
LYS4 YDR234W Homoaconitase genetic 1 1 1 Synthetic Lethality
GCV1 YDR019C T subunit of the mitochondrial glycine decarboxylase complex genetic 1 1 1 Synthetic Lethality
SHM1 YBR263W Mitochondrial serine hydroxymethyltransferase genetic 1 1 1 Synthetic Lethality
SHM2 YLR058C Cytosolic serine hydroxymethyltransferase genetic 1 1 1 Synthetic Lethality
CAJ1 YER048C Nuclear type II J heat shock protein of the E. coli dnaJ family genetic 1 1 1 Negative Genetic
MDM12 YOL009C Mitochondrial outer membrane protein, ERMES complex subunit genetic 1 1 1 Negative Genetic
LAT1 YNL071W Dihydrolipoamide acetyltransferase component (E2) of the PDC genetic 1 1 1 Negative Genetic
RBK1 YCR036W Ribokinase, phosphorylates ribose to ribose-5-phosphate genetic 1 1 1 Negative Genetic
HNM1 YGL077C Plasma membrane transporter for choline, ethanolamine, and carnitine genetic 1 1 1 Negative Genetic
SDT1 YGL224C Pyrimidine nucleotidase genetic 1 1 1 Negative Genetic
BTS1 YPL069C Geranylgeranyl diphosphate synthase (GGPPS) genetic 1 1 1 Negative Genetic
THR4 YCR053W Threonine synthase genetic 1 1 1 Positive Genetic
PDA1 YER178W E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex genetic 1 1 1 Negative Genetic
NPL3 YDR432W RNA-binding protein genetic 1 1 1 Synthetic Rescue
SMC1 YFL008W Subunit of the multiprotein cohesin complex genetic 1 1 1 Negative Genetic
SCC2 YDR180W Subunit of cohesin loading factor (Scc2p-Scc4p) genetic 1 1 1 Negative Genetic
TES1 YJR019C Peroxisomal acyl-CoA thioesterase genetic 1 1 1 Phenotypic Enhancement
CBF5 YLR175W Pseudouridine synthase catalytic subunit of box H/ACA snoRNPs genetic 1 1 1 Positive Genetic
TIF34 YMR146C eIF3i subunit of the eukaryotic translation initiation factor 3 (eIF3) genetic 1 1 1 Positive Genetic
TAF3 YPL011C TFIID subunit (47 kDa) genetic 1 1 1 Positive Genetic
EAP1 YKL204W eIF4E-associated protein, competes with eIF4G for binding to eIF4E genetic 1 1 1 Positive Genetic
TCB3 YML072C Cortical ER protein involved in ER-plasma membrane tethering genetic 1 1 1 Positive Genetic
PAB1 YER165W Poly(A) binding protein genetic 1 1 1 Negative Genetic
LAS1 YKR063C Endonuclease involved in pre-rRNA processing at both ends of ITS2 genetic 1 1 1 Negative Genetic
PBR1 YNL181W Putative oxidoreductase genetic 1 1 1 Negative Genetic
SAC6 YDR129C Fimbrin, actin-bundling protein genetic 1 1 1 Negative Genetic
NKP1 YDR383C Central kinetochore protein and subunit of the Ctf19 complex genetic 1 1 1 Negative Genetic
MRP20 YDR405W Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
EMI1 YDR512C Non-essential protein of unknown function genetic 1 1 1 Negative Genetic
TRP2 YER090W Anthranilate synthase genetic 1 1 1 Negative Genetic
MDM34 YGL219C Mitochondrial component of the ERMES complex genetic 1 1 1 Negative Genetic
GPR1 YDL035C Plasma membrane G protein coupled receptor (GPCR) genetic 1 1 1 Negative Genetic
YHR045W YHR045W Putative protein of unknown function genetic 1 1 1 Negative Genetic
IST3 YIR005W Component of the U2 snRNP genetic 1 1 1 Negative Genetic
VPS27 YNR006W Endosomal protein that forms a complex with Hse1p genetic 1 1 1 Negative Genetic
TUF1 YOR187W Mitochondrial translation elongation factor Tu (EF-Tu) genetic 1 1 1 Negative Genetic
MGM1 YOR211C Mitochondrial GTPase, present in complex with Ugo1p and Fzo1p genetic 1 1 1 Negative Genetic
BNA5 YLR231C Kynureninase genetic 1 1 1 Phenotypic Suppression
BNA6 YFR047C Quinolinate phosphoribosyl transferase genetic 1 1 1 Phenotypic Suppression
BNA7 YDR428C Formylkynurenine formamidase genetic 1 1 1 Phenotypic Suppression
HRQ1 YDR291W 3'-5' DNA helicase of the conserved RecQ family genetic 1 1 1 Positive Genetic
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 1 1 1 Positive Genetic