Standard name Systematic name Name description Description
SAC6 YDR129C Fimbrin, actin-bundling protein Fimbrin, actin-bundling protein; cooperates with Scp1p in organization and maintenance of the actin cytoskeleton; phosphorylated by Cdc28p/Clb2p in metaphase on T103, to regulate conformation, and modulate actin filament binding affinity and actin cable dynamics; relocalizes from the plasma membrane to the cytoplasm upon DNA replication stress; human homologs PLS3 and LCP1 implicated in spinocerebellar ataxia type 2 (SCA2) can each complement yeast null mutant
Visualize the interactome of SAC6
Links to external databases:
SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Bud 0.113 0.135 0.144
Cell Periphery 0.050 0.072 0.070
Cort. Patches 0.512 0.466 0.441
Cytoplasm 0.125 0.115 0.057
ER 0.062 0.120 NaN
Golgi 0.438 0.423 0.485
Mito 0.163 0.091 0.217

GFP localization & abundance

GFP localization GFP abundance
actin 3510

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
SAC6 0 0 0 0 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
ACT1 YFL039C Actin, structural protein in cytoskeleton genetic 18 6 12 Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Lethality, Synthetic Rescue, Synthetic Rescue, Synthetic Growth Defect, Phenotypic Suppression, Synthetic Growth Defect, Synthetic Haploinsufficiency, Negative Genetic
ACT1 YFL039C Actin, structural protein in cytoskeleton physical 9 5 7 Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Co-purification, Affinity Capture-MS, Co-fractionation, Affinity Capture-MS, Affinity Capture-Western
SCP1 YOR367W Component of yeast cortical actin cytoskeleton genetic 6 4 5 Dosage Rescue, Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Suppression
ABP1 YCR088W Actin-binding protein of the cortical actin cytoskeleton genetic 5 2 5 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect
CAP2 YIL034C Beta subunit of the capping protein heterodimer (Cap1p and Cap2p) genetic 4 3 4 Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect
BBC1 YJL020C Protein possibly involved in assembly of actin patches genetic 4 2 4 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic
MID2 YLR332W O-glycosylated plasma membrane protein genetic 4 3 3 Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect, Negative Genetic
SLA2 YNL243W Adaptor protein that links actin to clathrin and endocytosis genetic 4 1 2 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality
ARP2 YDL029W Essential component of the Arp2/3 complex genetic 3 2 3 Synthetic Lethality, Synthetic Lethality, Negative Genetic
TPM1 YNL079C Major isoform of tropomyosin genetic 3 2 2 Positive Genetic, Synthetic Rescue, Synthetic Rescue
PIK1 YNL267W Phosphatidylinositol 4-kinase genetic 3 1 2 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality
BNI1 YNL271C Formin physical 2 2 2 Reconstituted Complex, PCA
RFA1 YAR007C Subunit of heterotrimeric Replication Protein A (RPA) physical 2 2 2 Affinity Capture-MS, Two-hybrid
SKT5 YBL061C Activator of Chs3p (chitin synthase III) during vegetative growth genetic 2 2 2 Synthetic Lethality, Synthetic Growth Defect
TSC11 YER093C Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p) genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
GET1 YGL020C Subunit of the GET complex genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
PRK1 YIL095W Ser/Thr protein kinase genetic 2 2 2 Phenotypic Enhancement, Negative Genetic
CHS3 YBR023C Chitin synthase III genetic 2 2 2 Synthetic Lethality, Synthetic Growth Defect
PFY1 YOR122C Profilin genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
CHS5 YLR330W Component of the exomer complex genetic 2 2 2 Synthetic Lethality, Synthetic Growth Defect
HOC1 YJR075W Alpha-1,6-mannosyltransferase genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
CHS7 YHR142W Protein of unknown function genetic 2 2 2 Synthetic Lethality, Synthetic Growth Defect
CCW12 YLR110C Cell wall mannoprotein genetic 2 2 2 Synthetic Lethality, Negative Genetic
RPN11 YFR004W Metalloprotease subunit of 19S regulatory particle physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
ARC15 YIL062C Subunit of the ARP2/3 complex physical 2 1 2 PCA, PCA
ARC40 YBR234C Subunit of the ARP2/3 complex genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
RVS161 YCR009C Amphiphysin-like lipid raft protein genetic 2 1 2 Negative Genetic, Negative Genetic
RVS167 YDR388W Calmodulin-binding actin-associated protein genetic 2 1 2 Negative Genetic, Negative Genetic
AIM3 YBR108W Protein that inhibits barbed-end actin filament elongation genetic 2 1 2 Negative Genetic, Negative Genetic
BNI1 YNL271C Formin genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
HDA1 YNL021W Catalytic subunit of class II HDA1 histone deacetylase complex genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
RPD3 YNL330C Histone deacetylase, component of both the Rpd3S and Rpd3L complexes genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
SIN3 YOL004W Component of both the Rpd3S and Rpd3L histone deacetylase complexes genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
BIM1 YER016W Microtubule plus end-tracking protein genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
YAP6 YDR259C Basic leucine zipper (bZIP) transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CYC8 YBR112C General transcriptional co-repressor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
ESA1 YOR244W Catalytic subunit of the histone acetyltransferase complex (NuA4) physical 1 1 1 Affinity Capture-MS
RPL27A YHR010W Ribosomal 60S subunit protein L27A physical 1 1 1 Affinity Capture-MS
RPL38 YLR325C Ribosomal 60S subunit protein L38 physical 1 1 1 Affinity Capture-MS
BRE1 YDL074C E3 ubiquitin ligase genetic 1 1 1 Synthetic Growth Defect
PAT1 YCR077C Deadenylation-dependent mRNA-decapping factor genetic 1 1 1 Negative Genetic
LSM6 YDR378C Lsm (Like Sm) protein genetic 1 1 1 Negative Genetic
NPL3 YDR432W RNA-binding protein genetic 1 1 1 Synthetic Growth Defect
RRP6 YOR001W Nuclear exosome exonuclease component physical 1 1 1 Affinity Capture-MS
RET1 YOR207C Second-largest subunit of RNA polymerase III physical 1 1 1 Affinity Capture-MS
NOP12 YOL041C Nucleolar protein involved in pre-25S rRNA processing genetic 1 1 1 Negative Genetic
RPN1 YHR027C Non-ATPase base subunit of the 19S RP of the 26S proteasome physical 1 1 1 Affinity Capture-MS
RPN10 YHR200W Proteasome polyubiquitin receptor physical 1 1 1 Affinity Capture-MS
RPN11 YFR004W Metalloprotease subunit of 19S regulatory particle genetic 1 1 1 Negative Genetic
RPN7 YPR108W Essential non-ATPase regulatory subunit of the 26S proteasome genetic 1 1 1 Negative Genetic
PRE3 YJL001W Beta 1 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
PRE7 YBL041W Beta 6 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
AAH1 YNL141W Adenine deaminase (adenine aminohydrolase) genetic 1 1 1 Negative Genetic
AAR2 YBL074C Component of the U5 snRNP complex genetic 1 1 1 Negative Genetic
CDC39 YCR093W Subunit of the CCR4-NOT1 core complex genetic 1 1 1 Negative Genetic
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-RNA
ARC35 YNR035C Subunit of the ARP2/3 complex genetic 1 1 1 Negative Genetic
ARC40 YBR234C Subunit of the ARP2/3 complex physical 1 1 1 PCA
BET2 YPR176C Beta subunit of Type II geranylgeranyltransferase genetic 1 1 1 Negative Genetic
BEM2 YER155C Rho GTPase activating protein (RhoGAP) genetic 1 1 1 Synthetic Lethality
CAP1 YKL007W Alpha subunit of the capping protein heterodimer (Cap1p and Cap2p) genetic 1 1 1 Synthetic Lethality
AIM21 YIR003W Subunit of a complex that associates with actin filaments genetic 1 1 1 Negative Genetic
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit physical 1 1 1 Biochemical Activity
CDC3 YLR314C Component of the septin ring that is required for cytokinesis genetic 1 1 1 Positive Genetic
BUD31 YCR063W Component of the SF3b subcomplex of the U2 snRNP genetic 1 1 1 Negative Genetic
CTK1 YKL139W Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I) genetic 1 1 1 Positive Genetic
CIA2 YHR122W Component of cytosolic iron-sulfur protein assembly (CIA) machinery genetic 1 1 1 Negative Genetic
ELP2 YGR200C Subunit of Elongator complex genetic 1 1 1 Negative Genetic
FPR1 YNL135C Peptidyl-prolyl cis-trans isomerase (PPIase) physical 1 1 1 Affinity Capture-MS
CCT4 YDL143W Subunit of the cytosolic chaperonin Cct ring complex genetic 1 1 1 Negative Genetic
ESP1 YGR098C Separase/separin, a caspase-like cysteine protease physical 1 1 1 Affinity Capture-MS
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
KIN3 YAR018C Nonessential serine/threonine protein kinase genetic 1 1 1 Positive Genetic
KRR1 YCL059C Nucleolar protein required for rRNA synthesis and ribosomal assembly genetic 1 1 1 Negative Genetic
LAS17 YOR181W Actin assembly factor physical 1 1 1 Affinity Capture-MS
COG3 YER157W Essential component of the conserved oligomeric Golgi complex genetic 1 1 1 Negative Genetic
HSC82 YMR186W Cytoplasmic chaperone of the Hsp90 family physical 1 1 1 Affinity Capture-MS
HDA3 YPR179C Subunit of HDA1 histone deacetylase complex genetic 1 1 1 Negative Genetic
MUM2 YBR057C Protein essential for meiotic DNA replication and sporulation genetic 1 1 1 Negative Genetic
CMD1 YBR109C Calmodulin physical 1 1 1 Affinity Capture-MS
CMD1 YBR109C Calmodulin genetic 1 1 1 Negative Genetic
ATG18 YFR021W Phosphoinositide binding protein physical 1 1 1 Affinity Capture-MS
HSP42 YDR171W Small heat shock protein (sHSP) with chaperone activity physical 1 1 1 Affinity Capture-MS
ORC2 YBR060C Subunit of the origin recognition complex (ORC) genetic 1 1 1 Negative Genetic
GIM3 YNL153C Subunit of the heterohexameric cochaperone prefoldin complex genetic 1 1 1 Negative Genetic
PGK1 YCR012W 3-phosphoglycerate kinase physical 1 1 1 Affinity Capture-MS
HSP82 YPL240C Hsp90 chaperone physical 1 1 1 Affinity Capture-MS
PRP6 YBR055C Splicing factor physical 1 1 1 Affinity Capture-MS
PEP4 YPL154C Vacuolar aspartyl protease (proteinase A) physical 1 1 1 Affinity Capture-MS
RAD23 YEL037C Protein with ubiquitin-like N terminus physical 1 1 1 Affinity Capture-MS
MKT1 YNL085W Protein similar to nucleases that forms a complex with Pbp1p genetic 1 1 1 Negative Genetic
FYV8 YGR196C Protein of unknown function genetic 1 1 1 Negative Genetic
NUP145 YGL092W Essential protein with distinct roles in two nuclear pore subcomplexes physical 1 1 1 Affinity Capture-MS
MNN10 YDR245W Subunit of a Golgi mannosyltransferase complex genetic 1 1 1 Synthetic Lethality
RXT2 YBR095C Component of the histone deacetylase Rpd3L complex genetic 1 1 1 Negative Genetic
PRP18 YGR006W Splicing factor and component of snRNP U5 genetic 1 1 1 Negative Genetic
PRP11 YDL043C Subunit of the SF3a splicing factor complex genetic 1 1 1 Negative Genetic
RPT5 YOR117W ATPase of the 19S regulatory particle of the 26S proteasome physical 1 1 1 Affinity Capture-MS
CRN1 YLR429W Coronin genetic 1 1 1 Negative Genetic
ATG9 YDL149W Transmembrane protein involved in forming Cvt and autophagic vesicles physical 1 1 1 Affinity Capture-MS
BCK1 YJL095W MAPKKK acting in the protein kinase C signaling pathway genetic 1 1 1 Negative Genetic
RAD1 YPL022W Single-stranded DNA endonuclease (with Rad10p) physical 1 1 1 Affinity Capture-MS
DRS2 YAL026C Trans-golgi network aminophospholipid translocase (flippase) genetic 1 1 1 Negative Genetic
GET3 YDL100C Guanine nucleotide exchange factor for Gpa1p genetic 1 1 1 Negative Genetic
FAR11 YNL127W Protein involved in recovery from cell cycle arrest genetic 1 1 1 Negative Genetic
ABP1 YCR088W Actin-binding protein of the cortical actin cytoskeleton physical 1 1 1 Co-localization
MDH1 YKL085W Mitochondrial malate dehydrogenase physical 1 1 1 Affinity Capture-MS
CAF20 YOR276W Phosphoprotein of the mRNA cap-binding complex physical 1 1 1 Affinity Capture-MS
AAC3 YBR085W Mitochondrial inner membrane ADP/ATP translocator genetic 1 1 1 Synthetic Lethality
TRR1 YDR353W Cytoplasmic thioredoxin reductase physical 1 1 1 Affinity Capture-MS
SAT4 YCR008W Ser/Thr protein kinase involved in salt tolerance, nutrient response physical 1 1 1 Affinity Capture-MS
TIF2 YJL138C Translation initiation factor eIF4A physical 1 1 1 Affinity Capture-MS
YPK1 YKL126W S/T protein kinase physical 1 1 1 Affinity Capture-MS
SRS2 YJL092W DNA helicase and DNA-dependent ATPase physical 1 1 1 Affinity Capture-MS
SRS2 YJL092W DNA helicase and DNA-dependent ATPase genetic 1 1 1 Dosage Lethality
TOR1 YJR066W PIK-related protein kinase and rapamycin target physical 1 1 1 Co-fractionation
TOR1 YJR066W PIK-related protein kinase and rapamycin target genetic 1 1 1 Synthetic Lethality
TOR2 YKL203C PIK-related protein kinase and rapamycin target physical 1 1 1 Co-fractionation
SRV2 YNL138W CAP (cyclase-associated protein) physical 1 1 1 PCA
SRV2 YNL138W CAP (cyclase-associated protein) genetic 1 1 1 Negative Genetic
SPB4 YFL002C Putative ATP-dependent RNA helicase physical 1 1 1 Affinity Capture-MS
SBP1 YHL034C Protein that binds eIF4G and has a role in repression of translation physical 1 1 1 Affinity Capture-RNA
SPT10 YJL127C Histone H3 acetylase with a role in transcriptional regulation physical 1 1 1 Affinity Capture-MS
SPT21 YMR179W Protein with a role in transcriptional silencing physical 1 1 1 Affinity Capture-MS
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
TEF1 YPR080W Translational elongation factor EF-1 alpha physical 1 1 1 Affinity Capture-MS
SGT2 YOR007C Glutamine-rich cytoplasmic cochaperone physical 1 1 1 Affinity Capture-MS
TOM1 YDR457W E3 ubiquitin ligase of the hect-domain class physical 1 1 1 Affinity Capture-MS
SUP35 YDR172W Translation termination factor eRF3 physical 1 1 1 Affinity Capture-MS
SUP35 YDR172W Translation termination factor eRF3 genetic 1 1 1 Phenotypic Suppression
TFC6 YDR362C Subunit of RNA polymerase III transcription initiation factor complex physical 1 1 1 Affinity Capture-MS
SCD5 YOR329C Protein required for normal actin organization and endocytosis genetic 1 1 1 Synthetic Growth Defect
VPS21 YOR089C Endosomal Rab family GTPase genetic 1 1 1 Synthetic Lethality
SWE1 YJL187C Protein kinase that regulates the G2/M transition genetic 1 1 1 Synthetic Lethality
TCO89 YPL180W Subunit of TORC1 (Tor1p or Tor2p-Kog1p-Lst8p-Tco89p) genetic 1 1 1 Synthetic Growth Defect
SPC1 YJR010C-A Subunit of the signal peptidase complex (SPC) genetic 1 1 1 Phenotypic Enhancement
VMA1 YDL185W Subunit A of the V1 peripheral membrane domain of V-ATPase genetic 1 1 1 Synthetic Lethality
TOP1 YOL006C Topoisomerase I genetic 1 1 1 Synthetic Growth Defect
SUR2 YDR297W Sphinganine C4-hydroxylase genetic 1 1 1 Positive Genetic
YPT31 YER031C Rab family GTPase genetic 1 1 1 Negative Genetic
VPS27 YNR006W Endosomal protein that forms a complex with Hse1p genetic 1 1 1 Negative Genetic
SET5 YHR207C Methyltransferase involved in methylation of histone H4 Lys5, -8, -12 genetic 1 1 1 Negative Genetic
VPS74 YDR372C Golgi PI4K effector, PtdIns4P sensor, and retention receptor genetic 1 1 1 Synthetic Growth Defect
TEF2 YBR118W Translational elongation factor EF-1 alpha genetic 1 1 1 Positive Genetic
SNF5 YBR289W Subunit of the SWI/SNF chromatin remodeling complex genetic 1 1 1 Positive Genetic
TAH1 YCR060W Component of conserved R2TP complex (Rvb1-Rvb2-Tah1-Pih1) genetic 1 1 1 Positive Genetic
SGF73 YGL066W Subunit of DUBm module of SAGA and SLIK genetic 1 1 1 Positive Genetic
SWI6 YLR182W Transcription cofactor genetic 1 1 1 Positive Genetic
SCS7 YMR272C Sphingolipid alpha-hydroxylase genetic 1 1 1 Positive Genetic
SEC17 YBL050W Alpha-SNAP cochaperone genetic 1 1 1 Negative Genetic
TAF5 YBR198C Subunit (90 kDa) of TFIID and SAGA complexes genetic 1 1 1 Negative Genetic
TFB1 YDR311W Subunit of TFIIH and nucleotide excision repair factor 3 complexes genetic 1 1 1 Negative Genetic
SYF1 YDR416W Member of the NineTeen Complex (NTC) genetic 1 1 1 Negative Genetic
YIP1 YGR172C Integral membrane protein genetic 1 1 1 Negative Genetic
SEC61 YLR378C Conserved ER protein translocation channel genetic 1 1 1 Negative Genetic
TAF8 YML114C TFIID subunit (65 kDa) genetic 1 1 1 Negative Genetic
SGT1 YOR057W Cochaperone protein genetic 1 1 1 Negative Genetic
SEC63 YOR254C Essential subunit of Sec63 complex genetic 1 1 1 Negative Genetic
SEC62 YPL094C Essential subunit of Sec63 complex genetic 1 1 1 Negative Genetic
TBF1 YPL128C Telobox-containing general regulatory factor genetic 1 1 1 Negative Genetic
YBL081W YBL081W Non-essential protein of unknown function genetic 1 1 1 Negative Genetic
UBC4 YBR082C Ubiquitin-conjugating enzyme (E2) genetic 1 1 1 Negative Genetic
SEC66 YBR171W Non-essential subunit of Sec63 complex genetic 1 1 1 Negative Genetic
YBR197C YBR197C Protein of unknown function genetic 1 1 1 Negative Genetic
SWC5 YBR231C Component of the SWR1 complex genetic 1 1 1 Negative Genetic
SUM1 YDR310C Transcriptional repressor that regulates middle-sporulation genes genetic 1 1 1 Negative Genetic
SAC7 YDR389W GTPase activating protein (GAP) for Rho1p genetic 1 1 1 Negative Genetic
WWM1 YFL010C WW domain containing protein of unknown function genetic 1 1 1 Negative Genetic
UBP6 YFR010W Ubiquitin-specific protease genetic 1 1 1 Negative Genetic
XRN1 YGL173C Evolutionarily-conserved 5'-3' exonuclease genetic 1 1 1 Negative Genetic
TWF1 YGR080W Twinfilin genetic 1 1 1 Negative Genetic
YTA7 YGR270W Chromatin-binding ATPase that regulates histone gene expression genetic 1 1 1 Negative Genetic
SLT2 YHR030C Serine/threonine MAP kinase genetic 1 1 1 Negative Genetic
YIL152W YIL152W Putative protein of unknown function genetic 1 1 1 Negative Genetic
SET2 YJL168C Histone methyltransferase with a role in transcriptional elongation genetic 1 1 1 Negative Genetic
STE24 YJR117W Highly conserved zinc metalloprotease genetic 1 1 1 Negative Genetic
UTH1 YKR042W Mitochondrial inner membrane protein genetic 1 1 1 Negative Genetic
SPA2 YLL021W Component of the polarisome genetic 1 1 1 Negative Genetic
SRN2 YLR119W Component of the ESCRT-I complex genetic 1 1 1 Negative Genetic
SAM1 YLR180W S-adenosylmethionine synthetase genetic 1 1 1 Negative Genetic
VID22 YLR373C G-quadruplex (G4) DNA binding protein genetic 1 1 1 Negative Genetic
SUR7 YML052W Plasma membrane protein, component of eisosomes genetic 1 1 1 Negative Genetic
SDD2 YMR074C Protein with homology to human PDCD5 genetic 1 1 1 Negative Genetic
YMR226C YMR226C NADP(+)-dependent serine dehydrogenase and carbonyl reductase genetic 1 1 1 Negative Genetic
YDJ1 YNL064C Type I HSP40 co-chaperone genetic 1 1 1 Negative Genetic
YAF9 YNL107W Subunit of NuA4 histone H4 acetyltransferase and SWR1 complexes genetic 1 1 1 Negative Genetic
UME1 YPL139C Component of both the Rpd3S and Rpd3L histone deacetylase complexes genetic 1 1 1 Negative Genetic
THP3 YPR045C Protein that may have a role in transcription elongation genetic 1 1 1 Negative Genetic
TKL1 YPR074C Transketolase genetic 1 1 1 Negative Genetic
YPR078C YPR078C Putative protein of unknown function genetic 1 1 1 Negative Genetic
VPS4 YPR173C AAA-ATPase involved in multivesicular body (MVB) protein sorting genetic 1 1 1 Synthetic Lethality
GSF2 YML048W Endoplasmic reticulum (ER) localized integral membrane protein genetic 1 1 1 Negative Genetic
FAA4 YMR246W Long chain fatty acyl-CoA synthetase physical 1 1 1 Affinity Capture-MS
GET2 YER083C Subunit of the GET complex genetic 1 1 1 Synthetic Lethality
CCT5 YJR064W Subunit of the cytosolic chaperonin Cct ring complex genetic 1 1 1 Negative Genetic
COF1 YLL050C Cofilin, involved in pH-dependent actin filament depolarization genetic 1 1 1 Synthetic Lethality
HSP104 YLL026W Disaggregase physical 1 1 1 Affinity Capture-MS
DYN2 YDR424C Cytoplasmic light chain dynein, microtubule motor protein genetic 1 1 1 Phenotypic Enhancement
MET30 YIL046W F-box protein containing five copies of the WD40 motif genetic 1 1 1 Negative Genetic
KAP122 YGL016W Karyopherin beta genetic 1 1 1 Positive Genetic
AIP1 YMR092C Actin cortical patch component genetic 1 1 1 Synthetic Growth Defect
RVS167 YDR388W Calmodulin-binding actin-associated protein physical 1 1 1 Two-hybrid
RAD6 YGL058W Ubiquitin-conjugating enzyme (E2) genetic 1 1 1 Synthetic Lethality
ERG6 YML008C Delta(24)-sterol C-methyltransferase genetic 1 1 1 Positive Genetic
HHT1 YBR010W Histone H3 genetic 1 1 1 Negative Genetic
ECM33 YBR078W GPI-anchored protein involved in efficient glucose uptake genetic 1 1 1 Negative Genetic
PAP2 YOL115W Non-canonical poly(A) polymerase genetic 1 1 1 Synthetic Lethality
CLN2 YPL256C G1 cyclin involved in regulation of the cell cycle genetic 1 1 1 Negative Genetic
ATG1 YGL180W Protein serine/threonine kinase physical 1 1 1 Affinity Capture-MS
IPK1 YDR315C Inositol 1,3,4,5,6-pentakisphosphate 2-kinase genetic 1 1 1 Negative Genetic
NUF2 YOL069W Component of the kinetochore-associated Ndc80 complex genetic 1 1 1 Negative Genetic
PCL2 YDL127W Cyclin, interacts with cyclin-dependent kinase Pho85p genetic 1 1 1 Positive Genetic
PKC1 YBL105C Protein serine/threonine kinase genetic 1 1 1 Negative Genetic
PRP5 YBR237W RNA helicase in the DEAD-box family genetic 1 1 1 Negative Genetic
RGA1 YOR127W GTPase-activating protein for polarity-regulator Cdc42p (RhoGAP) genetic 1 1 1 Negative Genetic
ELP6 YMR312W Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex genetic 1 1 1 Negative Genetic
PEX2 YJL210W RING-finger peroxin and E3 ubiquitin ligase genetic 1 1 1 Negative Genetic
RPS4A YJR145C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
CDC21 YOR074C Thymidylate synthase genetic 1 1 1 Phenotypic Enhancement
RPL9B YNL067W Ribosomal 60S subunit protein L9B genetic 1 1 1 Negative Genetic
ARP6 YLR085C Actin-related protein that binds nucleosomes genetic 1 1 1 Negative Genetic
RPS8A YBL072C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
ATG8 YBL078C Ub-like protein physical 1 1 1 Affinity Capture-MS
BFR1 YOR198C Component of mRNP complexes associated with polyribosomes physical 1 1 1 Affinity Capture-RNA
ELO2 YCR034W Fatty acid elongase, involved in sphingolipid biosynthesis genetic 1 1 1 Positive Genetic
FRQ1 YDR373W N-myristoylated calcium-binding protein genetic 1 1 1 Negative Genetic
GIM4 YEL003W Subunit of the heterohexameric cochaperone prefoldin complex genetic 1 1 1 Negative Genetic
HXK2 YGL253W Hexokinase isoenzyme 2 genetic 1 1 1 Negative Genetic
OST3 YOR085W Gamma subunit of the oligosaccharyltransferase complex of the ER lumen genetic 1 1 1 Negative Genetic
PEA2 YER149C Coiled-coil 12S polarisome subunit genetic 1 1 1 Negative Genetic
PEP8 YJL053W Vacuolar protein component of the retromer genetic 1 1 1 Positive Genetic
HSF1 YGL073W Trimeric heat shock transcription factor genetic 1 1 1 Negative Genetic
KAR2 YJL034W ATPase involved in protein import into the ER genetic 1 1 1 Negative Genetic
MOB1 YIL106W Component of the mitotic exit network physical 1 1 1 Proximity Label-MS
ERV46 YAL042W Protein localized to COPII-coated vesicles genetic 1 1 1 Negative Genetic
MPT5 YGL178W mRNA-binding protein of the PUF family physical 1 1 1 Affinity Capture-RNA
GYP1 YOR070C Cis-golgi GTPase-activating protein (GAP) for yeast Rabs genetic 1 1 1 Positive Genetic
BUD6 YLR319C Actin- and formin-interacting protein physical 1 1 1 PCA
AKR1 YDR264C Palmitoyl transferase involved in protein palmitoylation genetic 1 1 1 Negative Genetic
HMT1 YBR034C Nuclear SAM-dependent mono- and asymmetric methyltransferase physical 1 1 1 Affinity Capture-MS
MAC1 YMR021C Copper-sensing transcription factor genetic 1 1 1 Negative Genetic
HKR1 YDR420W Mucin family member that functions as an osmosensor in the HOG pathway genetic 1 1 1 Negative Genetic
RGD1 YBR260C GTPase-activating protein (RhoGAP) for Rho3p and Rho4p genetic 1 1 1 Negative Genetic
ARK1 YNL020C Ser/Thr protein kinase genetic 1 1 1 Phenotypic Enhancement
CHS5 YLR330W Component of the exomer complex physical 1 1 1 Affinity Capture-MS
HRD1 YOL013C Ubiquitin-protein ligase involved in ER-associated degradation (ERAD) physical 1 1 1 Affinity Capture-MS
GGA1 YDR358W Golgi-localized protein with homology to gamma-adaptin genetic 1 1 1 Negative Genetic
MNN11 YJL183W Subunit of a Golgi mannosyltransferase complex genetic 1 1 1 Negative Genetic
PMT1 YDL095W Protein O-mannosyltransferase of the ER membrane physical 1 1 1 Affinity Capture-MS
CAP2 YIL034C Beta subunit of the capping protein heterodimer (Cap1p and Cap2p) physical 1 1 1 PCA
RPS2 YGL123W Protein component of the small (40S) subunit physical 1 1 1 Affinity Capture-MS
RPS3 YNL178W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RIM20 YOR275C Protein involved in proteolytic activation of Rim101p genetic 1 1 1 Negative Genetic
RDS3 YPR094W Component of the SF3b subcomplex of the U2 snRNP genetic 1 1 1 Negative Genetic
INP51 YIL002C Phosphatidylinositol 4,5-bisphosphate 5-phosphatase genetic 1 1 1 Synthetic Rescue
GAB1 YLR459W Subunit of the glycosylphosphatidylinositol transamidase complex genetic 1 1 1 Negative Genetic
ERG5 YMR015C C-22 sterol desaturase genetic 1 1 1 Positive Genetic
FRA1 YLL029W Protein involved in negative regulation of iron regulon transcription genetic 1 1 1 Negative Genetic
CSF1 YLR087C Protein with structural similarity to lipid transport protein Vps13p genetic 1 1 1 Negative Genetic
HYR1 YIR037W Glutathione peroxidase genetic 1 1 1 Negative Genetic
PUF4 YGL014W Member of the PUF protein family physical 1 1 1 Affinity Capture-RNA
PUF4 YGL014W Member of the PUF protein family genetic 1 1 1 Negative Genetic
PMR1 YGL167C High affinity Ca2+/Mn2+ P-type ATPase genetic 1 1 1 Negative Genetic
MVB12 YGR206W ESCRT-I subunit required to stabilize ESCRT-I core complex oligomers genetic 1 1 1 Negative Genetic
IMP21 YIL154C Transcriptional activator involved in maintenance of ion homeostasis genetic 1 1 1 Negative Genetic
PPN1 YDR452W Dual endo- and exopolyphosphatase with a role in phosphate metabolism physical 1 1 1 Affinity Capture-MS
FTR1 YER145C High affinity iron permease genetic 1 1 1 Negative Genetic
LAM1 YHR155W Putative sterol transfer protein genetic 1 1 1 Negative Genetic
ELF1 YKL160W Transcription elongation factor with a conserved zinc finger domain genetic 1 1 1 Negative Genetic
RTT109 YLL002W Histone acetyltransferase genetic 1 1 1 Negative Genetic
MSS51 YLR203C Specific translational activator for the mitochondrial COX1 mRNA physical 1 1 1 Affinity Capture-MS
PKR1 YMR123W V-ATPase assembly factor genetic 1 1 1 Negative Genetic
ALT1 YLR089C Alanine transaminase (glutamic pyruvic transaminase) genetic 1 1 1 Negative Genetic
RPS0B YLR048W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
GPI17 YDR434W Transmembrane protein genetic 1 1 1 Negative Genetic
RPL43A YPR043W Ribosomal 60S subunit protein L43A genetic 1 1 1 Negative Genetic
GCS1 YDL226C ADP-ribosylation factor GTPase activating protein (ARF GAP) genetic 1 1 1 Synthetic Growth Defect
RPS19A YOL121C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
ABP140 YOR239W AdoMet-dependent tRNA methyltransferase and actin binding protein genetic 1 1 1 Phenotypic Suppression
ATG21 YPL100W Phosphoinositide binding protein genetic 1 1 1 Positive Genetic
CAB1 YDR531W Pantothenate kinase, ATP:D-pantothenate 4'-phosphotransferase genetic 1 1 1 Positive Genetic
FPS1 YLL043W Aquaglyceroporin, plasma membrane channel genetic 1 1 1 Negative Genetic
RUD3 YOR216C Golgi matrix protein genetic 1 1 1 Negative Genetic
BNA2 YJR078W Tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase genetic 1 1 1 Negative Genetic
HUR1 YGL168W Protein with a role in DNA repair genetic 1 1 1 Negative Genetic
PYP1 YNL010W Sugar alcohol phosphatase genetic 1 1 1 Negative Genetic
RPS27A YKL156W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
MNN2 YBR015C Alpha-1,2-mannosyltransferase genetic 1 1 1 Negative Genetic
LIP1 YMR298W Ceramide synthase subunit genetic 1 1 1 Positive Genetic
ARF3 YOR094W Glucose-repressible ADP-ribosylation factor genetic 1 1 1 Negative Genetic
COM2 YER130C Transcription factor that binds IME1 Upstream Activation Signal (UAS) genetic 1 1 1 Negative Genetic
GRX3 YDR098C Glutathione-dependent oxidoreductase physical 1 1 1 Affinity Capture-MS
LGE1 YPL055C Protein involved in histone H2B ubiquitination genetic 1 1 1 Synthetic Growth Defect
MEP1 YGR121C Ammonium permease genetic 1 1 1 Positive Genetic
MSC3 YLR219W Protein of unknown function genetic 1 1 1 Negative Genetic
KRE9 YJL174W Glycoprotein involved in cell wall beta-glucan assembly genetic 1 1 1 Negative Genetic
DCW1 YKL046C Putative mannosidase genetic 1 1 1 Negative Genetic
ERG3 YLR056W C-5 sterol desaturase genetic 1 1 1 Negative Genetic
KRE1 YNL322C Cell wall glycoprotein involved in beta-glucan assembly genetic 1 1 1 Synthetic Growth Defect
RPE1 YJL121C D-ribulose-5-phosphate 3-epimerase genetic 1 1 1 Negative Genetic
PFA4 YOL003C Palmitoyltransferase with autoacylation activity genetic 1 1 1 Negative Genetic
MET5 YJR137C Sulfite reductase beta subunit genetic 1 1 1 Negative Genetic
RPS25A YGR027C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
NCS2 YNL119W Protein required for uridine thiolation of Lys(UUU) and Glu(UUC) tRNAs genetic 1 1 1 Negative Genetic
NCS6 YGL211W Protein required for uridine thiolation of Gln, Lys, and Glu tRNAs genetic 1 1 1 Negative Genetic
MYG1 YER156C Protein involved in mitochondrial function physical 1 1 1 Proximity Label-MS
ERD1 YDR414C Predicted membrane protein required for lumenal ER protein retention genetic 1 1 1 Negative Genetic
DLT1 YMR126C Protein of unknown function genetic 1 1 1 Negative Genetic
BER1 YLR412W Protein involved in microtubule-related processes genetic 1 1 1 Negative Genetic
ATG22 YCL038C Vacuolar integral membrane protein required for efflux of amino acids genetic 1 1 1 Positive Genetic
ROT2 YBR229C Glucosidase II catalytic subunit physical 1 1 1 Affinity Capture-MS
GPI8 YDR331W Catalytic subunit of the ER membrane GPI transamidase complex genetic 1 1 1 Negative Genetic
ERD2 YBL040C HDEL receptor genetic 1 1 1 Negative Genetic
ROM1 YGR070W Guanine nucleotide exchange factor (GEF) for Rho1p genetic 1 1 1 Phenotypic Suppression
MFM1 YPL060W Mitochondrial inner membrane magnesium transporter genetic 1 1 1 Negative Genetic
CBT1 YKL208W Protein involved in 5' RNA end processing genetic 1 1 1 Positive Genetic
MTC4 YBR255W Protein of unknown function genetic 1 1 1 Negative Genetic
MAY24 YPR153W Peripheral ER membrane protein genetic 1 1 1 Negative Genetic
KRE5 YOR336W Protein required for beta-1,6 glucan biosynthesis genetic 1 1 1 Negative Genetic
MTC6 YHR151C Protein of unknown function genetic 1 1 1 Negative Genetic