Standard name Systematic name Name description Description
YAF9 YNL107W Subunit of NuA4 histone H4 acetyltransferase and SWR1 complexes Subunit of NuA4 histone H4 acetyltransferase and SWR1 complexes; may function to antagonize silencing near telomeres; interacts directly with Swc4p; has homology to human leukemogenic protein AF9; contains a YEATS domain
Visualize the interactome of YAF9
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.250 0.527 0.588
Mito 0.562 0.116 NaN
Nucleus 0.250 0.179 0.324
Vac/Vac Memb 0.125 0.205 0.059
Endosome NaN 0.080 NaN
SpindlePole NaN NaN 0.074

GFP localization & abundance

GFP localization GFP abundance
cytoplasm, nucleus 259

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
YAF9 1 0 0 0 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
SWR1 YDR334W Swi2/Snf2-related ATPase physical 18 4 17 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Co-purification, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-MS
EPL1 YFL024C Subunit of NuA4, an essential histone H4/H2A acetyltransferase complex physical 15 5 14 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Co-crystal Structure, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Co-purification, Reconstituted Complex
ESA1 YOR244W Catalytic subunit of the histone acetyltransferase complex (NuA4) physical 11 3 10 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Co-purification
SWC4 YGR002C Component of the Swr1p complex that incorporates Htz1p into chromatin physical 8 3 6 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Two-hybrid, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western
EAF1 YDR359C Component of the NuA4 histone acetyltransferase complex physical 8 3 6 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Co-crystal Structure
SPT8 YLR055C Subunit of the SAGA transcriptional regulatory complex genetic 8 3 5 Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect
SET3 YKR029C Defining member of the SET3 histone deacetylase complex genetic 7 3 6 Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Negative Genetic
GIM4 YEL003W Subunit of the heterohexameric cochaperone prefoldin complex genetic 7 2 6 Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic
TRA1 YHR099W Subunit of SAGA and NuA4 histone acetyltransferase complexes physical 7 2 5 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western
SIN3 YOL004W Component of both the Rpd3S and Rpd3L histone deacetylase complexes genetic 7 3 4 Negative Genetic, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect
EAF3 YPR023C Component of the Rpd3S histone deacetylase complex genetic 7 2 4 Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect
ASF1 YJL115W Nucleosome assembly factor genetic 6 4 5 Negative Genetic, Synthetic Growth Defect, Synthetic Lethality, Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Growth Defect
BRE1 YDL074C E3 ubiquitin ligase genetic 6 3 5 Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect
LGE1 YPL055C Protein involved in histone H2B ubiquitination genetic 6 3 5 Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect
ARP4 YJL081C Nuclear actin-related protein involved in chromatin remodeling physical 6 2 5 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western
RPD3 YNL330C Histone deacetylase, component of both the Rpd3S and Rpd3L complexes genetic 6 2 3 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic
SAP30 YMR263W Component of Rpd3L histone deacetylase complex genetic 6 2 3 Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect
EAF6 YJR082C Subunit of the NuA4 acetyltransferase complex genetic 6 2 3 Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
EAF5 YEL018W Non-essential subunit of the NuA4 acetyltransferase complex physical 5 2 5 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS
YNG2 YHR090C Subunit of NuA4, an essential histone acetyltransferase complex physical 5 2 5 Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western
PAC10 YGR078C Part of the heteromeric co-chaperone GimC/prefoldin complex genetic 5 3 4 Negative Genetic, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect
HHT1 YBR010W Histone H3 physical 5 3 4 Affinity Capture-MS, Reconstituted Complex, Protein-peptide, Reconstituted Complex, Reconstituted Complex
SPT3 YDR392W Subunit of the SAGA and SAGA-like transcriptional regulatory complexes genetic 5 3 4 Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect, Positive Genetic, Synthetic Growth Defect
SET2 YJL168C Histone methyltransferase with a role in transcriptional elongation genetic 5 2 4 Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect
SWD1 YAR003W Subunit of the COMPASS (Set1C) complex genetic 5 2 4 Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect
MPS2 YGL075C Essential membrane protein localized at nuclear envelope and SPBs physical 5 1 4 Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid
EAF1 YDR359C Component of the NuA4 histone acetyltransferase complex genetic 5 2 2 Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect
EAF5 YEL018W Non-essential subunit of the NuA4 acetyltransferase complex genetic 5 2 2 Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
ESA1 YOR244W Catalytic subunit of the histone acetyltransferase complex (NuA4) genetic 5 1 2 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality
BUB3 YOR026W Kinetochore checkpoint WD40 repeat protein genetic 4 3 4 Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Growth Defect
CIN2 YPL241C GTPase-activating protein (GAP) for Cin4p genetic 4 2 4 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic
HTZ1 YOL012C Histone variant H2AZ physical 4 1 4 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
CDC73 YLR418C Component of the Paf1p complex genetic 4 3 3 Negative Genetic, Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect
TAF14 YPL129W Subunit of TFIID, TFIIF, INO80, SWI/SNF, and NuA3 complexes genetic 4 3 3 Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect
BDF1 YLR399C BET family transcriptional regulator physical 4 3 3 Affinity Capture-MS, Affinity Capture-Western, Two-hybrid, Affinity Capture-MS
BIM1 YER016W Microtubule plus end-tracking protein genetic 4 3 3 Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect
RTF1 YGL244W Subunit of RNAPII-associated chromatin remodeling Paf1 complex genetic 4 2 3 Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect
LSM6 YDR378C Lsm (Like Sm) protein genetic 4 2 3 Negative Genetic, Synthetic Lethality, Synthetic Lethality, Negative Genetic
GIM3 YNL153C Subunit of the heterohexameric cochaperone prefoldin complex genetic 4 2 3 Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect
BRE2 YLR015W Subunit of COMPASS (Set1C) complex genetic 4 2 3 Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect
VPS72 YDR485C Htz1p-binding component of the SWR1 complex physical 4 2 3 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS
SWD3 YBR175W Essential subunit of the COMPASS (Set1C) complex genetic 4 2 3 Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect
ARP4 YJL081C Nuclear actin-related protein involved in chromatin remodeling genetic 4 1 1 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality
SWC4 YGR002C Component of the Swr1p complex that incorporates Htz1p into chromatin genetic 4 1 1 Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect
EPL1 YFL024C Subunit of NuA4, an essential histone H4/H2A acetyltransferase complex genetic 4 1 1 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality
ADA2 YDR448W Transcription coactivator genetic 4 1 1 Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect
PHO23 YNL097C Component of the Rpd3L histone deacetylase complex genetic 4 1 1 Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes genetic 4 1 1 Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect
CDC20 YGL116W Activator of anaphase-promoting complex/cyclosome (APC/C) genetic 4 1 1 Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect
YNG2 YHR090C Subunit of NuA4, an essential histone acetyltransferase complex genetic 4 1 1 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality
EAF7 YNL136W Subunit of the NuA4 histone acetyltransferase complex genetic 4 1 1 Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect
RIC1 YLR039C Protein involved in retrograde transport to the cis-Golgi network genetic 3 3 3 Negative Genetic, Synthetic Growth Defect, Positive Genetic
MAD2 YJL030W Component of the spindle-assembly checkpoint complex genetic 3 3 3 Synthetic Lethality, Negative Genetic, Synthetic Growth Defect
BRE5 YNR051C Ubiquitin protease cofactor genetic 3 3 3 Negative Genetic, Positive Genetic, Synthetic Growth Defect
LEO1 YOR123C Component of the Paf1 complex genetic 3 2 3 Negative Genetic, Negative Genetic, Synthetic Growth Defect
RVB1 YDR190C ATP-dependent DNA helicase, also known as pontin physical 3 2 3 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS
CTF18 YMR078C Subunit of a complex with Ctf8p genetic 3 2 3 Negative Genetic, Synthetic Growth Defect, Negative Genetic
GIM5 YML094W Subunit of the heterohexameric cochaperone prefoldin complex genetic 3 2 3 Negative Genetic, Negative Genetic, Synthetic Growth Defect
HOS2 YGL194C Histone deacetylase and subunit of Set3 and Rpd3L complexes genetic 3 2 3 Negative Genetic, Negative Genetic, Synthetic Growth Defect
SIF2 YBR103W WD40 repeat-containing subunit of Set3C histone deacetylase complex genetic 3 2 3 Negative Genetic, Negative Genetic, Synthetic Growth Defect
SNT1 YCR033W Set3C histone deacetylase scaffold genetic 3 2 3 Negative Genetic, Negative Genetic, Synthetic Growth Defect
SAC3 YDR159W mRNA export factor genetic 3 2 3 Negative Genetic, Negative Genetic, Synthetic Growth Defect
CTF8 YHR191C Subunit of a complex with Ctf18p genetic 3 2 3 Negative Genetic, Synthetic Growth Defect, Negative Genetic
SEC22 YLR268W R-SNARE protein genetic 3 2 3 Negative Genetic, Negative Genetic, Synthetic Growth Defect
YPT6 YLR262C Rab family GTPase genetic 3 2 3 Negative Genetic, Negative Genetic, Synthetic Growth Defect
CIN1 YOR349W Tubulin folding factor D involved in beta-tubulin (Tub2p) folding genetic 3 2 3 Negative Genetic, Negative Genetic, Synthetic Growth Defect
SWC3 YAL011W Protein of unknown function physical 3 2 3 Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS
MNN11 YJL183W Subunit of a Golgi mannosyltransferase complex genetic 3 2 3 Positive Genetic, Negative Genetic, Negative Genetic
MRC1 YCL061C S-phase checkpoint protein required for DNA replication genetic 3 2 3 Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect
ACT1 YFL039C Actin, structural protein in cytoskeleton physical 3 1 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
PAC11 YDR488C Dynein intermediate chain, microtubule motor protein genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
EAF6 YJR082C Subunit of the NuA4 acetyltransferase complex physical 3 1 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
EAF7 YNL136W Subunit of the NuA4 histone acetyltransferase complex physical 3 1 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
LDB18 YLL049W Component of the dynactin complex genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
BDF1 YLR399C BET family transcriptional regulator genetic 3 2 2 Dosage Rescue, Synthetic Growth Defect, Synthetic Growth Defect
CSE2 YNR010W Subunit of the RNA polymerase II mediator complex genetic 3 2 2 Synthetic Lethality, Synthetic Lethality, Negative Genetic
ARP8 YOR141C Nuclear actin-related protein involved in chromatin remodeling genetic 3 2 2 Synthetic Growth Defect, Synthetic Growth Defect, Positive Genetic
SIR2 YDL042C Conserved NAD+ dependent histone deacetylase of the Sirtuin family genetic 3 2 2 Synthetic Growth Defect, Phenotypic Suppression, Synthetic Growth Defect
HFI1 YPL254W Adaptor protein required for structural integrity of the SAGA complex genetic 3 2 2 Negative Genetic, Synthetic Lethality, Synthetic Lethality
RAD6 YGL058W Ubiquitin-conjugating enzyme (E2) genetic 3 2 2 Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Lethality
DIA2 YOR080W Origin-binding F-box protein genetic 3 2 2 Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Lethality
SSN8 YNL025C Cyclin-like component of RNA polymerase II holoenzyme genetic 3 2 2 Negative Genetic, Synthetic Lethality, Synthetic Lethality
YKE2 YLR200W Subunit of the heterohexameric Gim/prefoldin protein complex genetic 3 2 2 Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect
SSN2 YDR443C Subunit of the RNA polymerase II mediator complex genetic 3 2 2 Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect
GLN3 YER040W Transcriptional activator in nitrogen catabolite repression system genetic 3 2 2 Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
SOH1 YGL127C Subunit of the RNA polymerase II mediator complex genetic 3 2 2 Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
CSF1 YLR087C Protein with structural similarity to lipid transport protein Vps13p genetic 3 2 2 Negative Genetic, Synthetic Lethality, Synthetic Lethality
SAS5 YOR213C Subunit of the SAS complex (Sas2p, Sas4p, Sas5p) genetic 3 2 2 Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect
TUB3 YML124C Alpha-tubulin genetic 3 2 2 Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect
RPA34 YJL148W RNA polymerase I subunit A34.5 genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
SRB2 YHR041C Subunit of the RNA polymerase II mediator complex genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
BDF2 YDL070W Protein involved in transcription initiation genetic 2 2 2 Phenotypic Enhancement, Negative Genetic
HHF1 YBR009C Histone H4 physical 2 2 2 Protein-peptide, Reconstituted Complex
MED1 YPR070W Subunit of the RNA polymerase II mediator complex genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
NUP60 YAR002W FG-nucleoporin component of central core of the nuclear pore complex genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
PRE9 YGR135W Alpha 3 subunit of the 20S proteasome genetic 2 2 2 Positive Genetic, Synthetic Rescue
SDC1 YDR469W Subunit of the COMPASS (Set1C) complex genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
SPP1 YPL138C Subunit of COMPASS (Set1C) genetic 2 2 2 Phenotypic Enhancement, Negative Genetic
GET1 YGL020C Subunit of the GET complex genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
GET2 YER083C Subunit of the GET complex genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
SLX5 YDL013W Subunit of the Slx5-Slx8 SUMO-targeted Ub ligase (STUbL) complex genetic 2 2 2 Negative Genetic, Synthetic Lethality
CTF4 YPR135W Chromatin-associated protein genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
RAD53 YPL153C DNA damage response kinase genetic 2 2 2 Negative Genetic, Synthetic Lethality
SWC7 YLR385C Protein of unknown function physical 2 2 2 Affinity Capture-Western, Affinity Capture-MS
SWI4 YER111C DNA binding component of the SBF complex (Swi4p-Swi6p) genetic 2 2 2 Phenotypic Enhancement, Negative Genetic
YAF9 YNL107W Subunit of NuA4 histone H4 acetyltransferase and SWR1 complexes physical 2 2 2 Affinity Capture-MS, Two-hybrid
YML119W YML119W Putative protein of unknown function genetic 2 2 2 Positive Genetic, Negative Genetic
CST9 YLR394W SUMO E3 ligase genetic 2 2 2 Positive Genetic, Dosage Growth Defect
POL32 YJR043C Third subunit of DNA polymerase delta genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
HHT2 YNL031C Histone H3 physical 2 2 2 Affinity Capture-MS, Reconstituted Complex
RPN4 YDL020C Transcription factor that stimulates expression of proteasome genes genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 2 2 2 Affinity Capture-MS, Co-purification
EUC1 YMR111C Sequence-specific DNA binding protein genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
JHD2 YJR119C JmjC domain family histone demethylase genetic 2 2 2 Phenotypic Enhancement, Negative Genetic
NTO1 YPR031W Subunit of the NuA3 histone acetyltransferase complex genetic 2 2 2 Phenotypic Enhancement, Negative Genetic
DCC1 YCL016C Subunit of a complex with Ctf8p and Ctf18p genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
SLX8 YER116C Subunit of Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
UBP3 YER151C Ubiquitin-specific protease that cleaves Ub-protein fusions genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
THP1 YOL072W Nuclear pore-associated protein genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
CHL4 YDR254W Outer kinetochore protein required for chromosome stability genetic 2 1 2 Negative Genetic, Negative Genetic
CKB1 YGL019W Beta regulatory subunit of casein kinase 2 (CK2) genetic 2 1 2 Negative Genetic, Negative Genetic
RVB2 YPL235W ATP-dependent DNA helicase, also known as reptin physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
LSM1 YJL124C Lsm (Like Sm) protein genetic 2 1 2 Negative Genetic, Negative Genetic
RRP6 YOR001W Nuclear exosome exonuclease component genetic 2 1 2 Negative Genetic, Negative Genetic
DPB3 YBR278W Third-largest subunit of DNA polymerase II (DNA polymerase epsilon) genetic 2 1 2 Negative Genetic, Negative Genetic
ELP2 YGR200C Subunit of Elongator complex genetic 2 1 2 Negative Genetic, Negative Genetic
EAF3 YPR023C Component of the Rpd3S histone deacetylase complex physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
HHF1 YBR009C Histone H4 genetic 2 1 2 Positive Genetic, Positive Genetic
HTZ1 YOL012C Histone variant H2AZ genetic 2 1 2 Positive Genetic, Positive Genetic
RCO1 YMR075W Essential component of the Rpd3S histone deacetylase complex genetic 2 1 2 Negative Genetic, Negative Genetic
CTI6 YPL181W Component of the Rpd3L histone deacetylase complex genetic 2 1 2 Negative Genetic, Negative Genetic
NUM1 YDR150W Protein required for nuclear migration genetic 2 1 2 Negative Genetic, Negative Genetic
PIL1 YGR086C Eisosome core component genetic 2 1 2 Negative Genetic, Negative Genetic
ANP1 YEL036C Subunit of the alpha-1,6 mannosyltransferase complex genetic 2 1 2 Negative Genetic, Negative Genetic
RXT2 YBR095C Component of the histone deacetylase Rpd3L complex genetic 2 1 2 Negative Genetic, Negative Genetic
TAF5 YBR198C Subunit (90 kDa) of TFIID and SAGA complexes genetic 2 1 2 Negative Genetic, Negative Genetic
RVS167 YDR388W Calmodulin-binding actin-associated protein genetic 2 1 2 Negative Genetic, Negative Genetic
HHT1 YBR010W Histone H3 genetic 2 1 2 Synthetic Growth Defect, Synthetic Growth Defect
PAP2 YOL115W Non-canonical poly(A) polymerase genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
ARP1 YHR129C Actin-related protein of the dynactin complex genetic 2 1 2 Negative Genetic, Negative Genetic
PKC1 YBL105C Protein serine/threonine kinase genetic 2 1 2 Negative Genetic, Negative Genetic
PEP12 YOR036W Target membrane receptor (t-SNARE) genetic 2 1 2 Negative Genetic, Negative Genetic
SWR1 YDR334W Swi2/Snf2-related ATPase genetic 2 1 2 Positive Genetic, Positive Genetic
SWC5 YBR231C Component of the SWR1 complex physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
VPS71 YML041C Nucleosome-binding component of the SWR1 complex physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
BUB1 YGR188C Protein kinase involved in the cell cycle checkpoint into anaphase genetic 2 1 2 Negative Genetic, Negative Genetic
MAD1 YGL086W Coiled-coil protein involved in spindle-assembly checkpoint genetic 2 1 2 Negative Genetic, Negative Genetic
YTA7 YGR270W Chromatin-binding ATPase that regulates histone gene expression genetic 2 1 2 Negative Genetic, Negative Genetic
JNM1 YMR294W Component of the yeast dynactin complex genetic 2 1 2 Negative Genetic, Negative Genetic
NIP100 YPL174C Large subunit of the dynactin complex genetic 2 1 2 Negative Genetic, Negative Genetic
CHS5 YLR330W Component of the exomer complex genetic 2 1 2 Negative Genetic, Negative Genetic
VPS72 YDR485C Htz1p-binding component of the SWR1 complex genetic 2 1 2 Positive Genetic, Positive Genetic
HOC1 YJR075W Alpha-1,6-mannosyltransferase genetic 2 1 2 Negative Genetic, Negative Genetic
INP51 YIL002C Phosphatidylinositol 4,5-bisphosphate 5-phosphatase genetic 2 1 2 Negative Genetic, Negative Genetic
ORM2 YLR350W Protein that mediates sphingolipid homeostasis genetic 2 1 2 Negative Genetic, Negative Genetic
HCM1 YCR065W Forkhead transcription factor genetic 2 1 2 Negative Genetic, Negative Genetic
SEM1 YDR363W-A 19S proteasome regulatory particle lid subcomplex component genetic 2 1 2 Negative Genetic, Negative Genetic
UBP2 YOR124C Ubiquitin-specific protease genetic 2 1 2 Negative Genetic, Negative Genetic
PMR1 YGL167C High affinity Ca2+/Mn2+ P-type ATPase genetic 2 1 2 Negative Genetic, Negative Genetic
MSS1 YMR023C Mitochondrial protein genetic 2 1 2 Negative Genetic, Negative Genetic
SUM1 YDR310C Transcriptional repressor that regulates middle-sporulation genes genetic 2 1 2 Negative Genetic, Negative Genetic
SCS7 YMR272C Sphingolipid alpha-hydroxylase genetic 2 1 2 Negative Genetic, Negative Genetic
MOT3 YMR070W Transcriptional repressor, activator genetic 2 1 2 Negative Genetic, Negative Genetic
PFD1 YJL179W Subunit of heterohexameric prefoldin genetic 2 1 2 Negative Genetic, Negative Genetic
VMA9 YCL005W-A Vacuolar H+ ATPase subunit e of the V-ATPase V0 subcomplex genetic 2 1 2 Positive Genetic, Positive Genetic
PMP3 YDR276C Small plasma membrane protein genetic 2 1 2 Negative Genetic, Negative Genetic
ULS1 YOR191W Swi2/Snf2-related translocase, SUMO-Targeted Ubiquitin Ligase (STUbL) genetic 2 1 2 Negative Genetic, Negative Genetic
CKS1 YBR135W Cyclin-dependent protein kinase regulatory subunit and adaptor physical 2 2 1 Affinity Capture-Western, Affinity Capture-MS
NUP170 YBL079W Subunit of inner ring of nuclear pore complex (NPC) genetic 2 2 1 Synthetic Growth Defect, Synthetic Lethality
CBC2 YPL178W Small subunit of the heterodimeric cap binding complex with Sto1p genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
STO1 YMR125W Large subunit of the nuclear mRNA cap-binding protein complex genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
SIN4 YNL236W Subunit of the RNA polymerase II mediator complex genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
APC1 YNL172W Largest subunit of the Anaphase-Promoting Complex/Cyclosome genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
APC2 YLR127C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
CDC12 YHR107C Component of the septin ring that is required for cytokinesis physical 2 1 1 Two-hybrid, Two-hybrid
BNI1 YNL271C Formin genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
HDA1 YNL021W Catalytic subunit of class II HDA1 histone deacetylase complex genetic 2 1 1 Synthetic Rescue, Synthetic Rescue
CTK1 YKL139W Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I) genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
CDC23 YHR166C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
HDA3 YPR179C Subunit of HDA1 histone deacetylase complex genetic 2 1 1 Synthetic Rescue, Synthetic Rescue
HDA2 YDR295C Subunit of HDA1 histone deacetylase complex genetic 2 1 1 Synthetic Rescue, Synthetic Rescue
PEP3 YLR148W Component of CORVET membrane tethering complex genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
LEA1 YPL213W Component of U2 snRNP complex genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
REF2 YDR195W RNA-binding protein genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
NUM1 YDR150W Protein required for nuclear migration physical 2 1 1 Two-hybrid, Two-hybrid
SCS2 YER120W Integral ER membrane protein, regulates phospholipid metabolism genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
NUP120 YKL057C Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
MSL1 YIR009W U2B component of U2 snRNP genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
NGG1 YDR176W Subunit of chromatin modifying histone acetyltransferase complexes genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
SPS1 YDR523C STE20-family GCKIII protein kinase genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
GRR1 YJR090C F-box protein component of an SCF ubiquitin-ligase complex genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
AAT2 YLR027C Cytosolic aspartate aminotransferase involved in nitrogen metabolism genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
RGP1 YDR137W Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
ACS2 YLR153C Acetyl-coA synthetase isoform genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
RSN1 YMR266W Membrane protein of unknown function genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
KEL2 YGR238C Protein that negatively regulates mitotic exit genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
IST3 YIR005W Component of the U2 snRNP genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
PEX14 YGL153W Central component of the peroxisomal importomer complex genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
SLM1 YIL105C Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm2p genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
SNO4 YMR322C Possible chaperone and cysteine protease genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
APC11 YDL008W Catalytic core subunit, Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
COG5 YNL051W Component of the conserved oligomeric Golgi complex genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
PEX10 YDR265W Peroxisomal membrane E3 ubiquitin ligase genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
PEX13 YLR191W Peroxisomal importomer complex component genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
RSC1 YGR056W Component of the RSC chromatin remodeling complex genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
TAF9 YMR236W Subunit (17 kDa) of TFIID and SAGA complexes genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
SWI3 YJL176C Subunit of the SWI/SNF chromatin remodeling complex genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
SWI6 YLR182W Transcription cofactor genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
DBP5 YOR046C Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
TIP20 YGL145W Peripheral membrane protein required for COPI vesicle fusion to the ER physical 2 1 1 Two-hybrid, Two-hybrid
ZIP1 YDR285W Transverse filament protein of the synaptonemal complex physical 2 1 1 Two-hybrid, Two-hybrid
YPL216W YPL216W Putative protein of unknown function physical 2 1 1 Two-hybrid, Two-hybrid
YME1 YPR024W Catalytic subunit of i-AAA protease complex genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
CNM67 YNL225C Component of the spindle pole body outer plaque physical 2 1 1 Two-hybrid, Two-hybrid
ARG82 YDR173C Inositol polyphosphate multikinase (IPMK) genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
NNF2 YGR089W Protein that exhibits physical and genetic interactions with Rpb8p physical 2 1 1 Two-hybrid, Two-hybrid
ARK1 YNL020C Ser/Thr protein kinase genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
INH1 YDL181W Protein that inhibits ATP hydrolysis by the F1F0-ATP synthase genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
GTA1 YEL043W Protein of unknown function physical 2 1 1 Two-hybrid, Two-hybrid
ERG2 YMR202W C-8 sterol isomerase genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
TOS8 YGL096W Homeodomain-containing protein and putative transcription factor genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
LDB7 YBL006C Component of the RSC chromatin remodeling complex genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
RNH70 YGR276C 3'-5' exoribonuclease genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
SGO1 YOR073W Component of the spindle checkpoint genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
VPS75 YNL246W NAP family histone chaperone genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
PEX8 YGR077C Intraperoxisomal organizer of the peroxisomal import machinery genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
TSC11 YER093C Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p) physical 2 1 1 Two-hybrid, Two-hybrid
TRM9 YML014W tRNA methyltransferase genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
FKH1 YIL131C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
RFX1 YLR176C Major transcriptional repressor of DNA-damage-regulated genes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MED2 YDL005C Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
YAP6 YDR259C Basic leucine zipper (bZIP) transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
YAP1 YML007W Basic leucine zipper (bZIP) transcription factor regulation 1 1 1 DNA to cDNA expression microarray evidence
RPD3 YNL330C Histone deacetylase, component of both the Rpd3S and Rpd3L complexes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CTF19 YPL018W Outer kinetochore protein, needed for accurate chromosome segregation genetic 1 1 1 Negative Genetic
MCM22 YJR135C Outer kinetochore protein and component of the Ctf3 subcomplex genetic 1 1 1 Negative Genetic
CKB2 YOR039W Beta' regulatory subunit of casein kinase 2 (CK2) genetic 1 1 1 Negative Genetic
IKI3 YLR384C Subunit of Elongator complex physical 1 1 1 Affinity Capture-MS
EBP2 YKL172W Required for 25S rRNA maturation and 60S ribosomal subunit assembly genetic 1 1 1 Negative Genetic
PFK27 YOL136C 6-phosphofructo-2-kinase genetic 1 1 1 Dosage Growth Defect
BRR2 YER172C RNA-dependent ATPase RNA helicase (DEIH box) genetic 1 1 1 Negative Genetic
MCM21 YDR318W Component of the kinetochore sub-complex COMA genetic 1 1 1 Negative Genetic
BMH1 YER177W 14-3-3 protein, major isoform genetic 1 1 1 Negative Genetic
SAP185 YJL098W Protein that forms a complex with the Sit4p protein phosphatase physical 1 1 1 Affinity Capture-MS
XRN1 YGL173C Evolutionarily-conserved 5'-3' exonuclease genetic 1 1 1 Negative Genetic
PAT1 YCR077C Deadenylation-dependent mRNA-decapping factor genetic 1 1 1 Negative Genetic
CDC48 YDL126C AAA ATPase with protein-unfoldase activity genetic 1 1 1 Positive Genetic
NPL3 YDR432W RNA-binding protein genetic 1 1 1 Synthetic Growth Defect
RRP43 YCR035C Exosome non-catalytic core component genetic 1 1 1 Positive Genetic
RPA49 YNL248C RNA polymerase I subunit A49 genetic 1 1 1 Positive Genetic
RPB4 YJL140W RNA polymerase II subunit B32 genetic 1 1 1 Positive Genetic
THP2 YHR167W Subunit of the THO and TREX complexes genetic 1 1 1 Negative Genetic
RTT102 YGR275W Component of both the SWI/SNF and RSC chromatin remodeling complexes genetic 1 1 1 Negative Genetic
DST1 YGL043W General transcription elongation factor TFIIS genetic 1 1 1 Negative Genetic
RPN10 YHR200W Proteasome polyubiquitin receptor genetic 1 1 1 Synthetic Rescue
ACT1 YFL039C Actin, structural protein in cytoskeleton genetic 1 1 1 Dosage Growth Defect
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex genetic 1 1 1 Synthetic Growth Defect
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-RNA
ARD1 YHR013C Subunit of protein N-terminal acetyltransferase NatA genetic 1 1 1 Synthetic Growth Defect
BEM2 YER155C Rho GTPase activating protein (RhoGAP) genetic 1 1 1 Positive Genetic
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit genetic 1 1 1 Synthetic Growth Defect
CDC11 YJR076C Component of the septin ring that is required for cytokinesis genetic 1 1 1 Dosage Growth Defect
CDC3 YLR314C Component of the septin ring that is required for cytokinesis physical 1 1 1 Two-hybrid
ATP11 YNL315C Molecular chaperone genetic 1 1 1 Negative Genetic
DOA1 YKL213C WD-repeat protein involved in ubiquitin-mediated protein degradation genetic 1 1 1 Negative Genetic
DYN1 YKR054C Cytoplasmic heavy chain dynein genetic 1 1 1 Negative Genetic
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
HST1 YOL068C NAD(+)-dependent histone deacetylase genetic 1 1 1 Phenotypic Enhancement
DPB4 YDR121W Subunit of DNA pol epsilon and of ISW2 chromatin accessibility complex genetic 1 1 1 Negative Genetic
COG8 YML071C Component of the conserved oligomeric Golgi complex genetic 1 1 1 Negative Genetic
IOC3 YFR013W Subunit of the Isw1a complex genetic 1 1 1 Synthetic Growth Defect
ISW1 YBR245C ATPase subunit of imitation-switch (ISWI) class chromatin remodelers genetic 1 1 1 Synthetic Lethality
ESC8 YOL017W Protein involved in telomeric and mating-type locus silencing genetic 1 1 1 Synthetic Growth Defect
KIN3 YAR018C Nonessential serine/threonine protein kinase genetic 1 1 1 Phenotypic Enhancement
END3 YNL084C EH domain-containing protein involved in endocytosis physical 1 1 1 Two-hybrid
CRM1 YGR218W Nuclear export factor, exportin physical 1 1 1 Affinity Capture-MS
FAB1 YFR019W 1-phosphatidylinositol-3-phosphate 5-kinase genetic 1 1 1 Negative Genetic
MRPL10 YNL284C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
HDA2 YDR295C Subunit of HDA1 histone deacetylase complex physical 1 1 1 Two-hybrid
MSH2 YOL090W Protein that binds to DNA mismatches genetic 1 1 1 Positive Genetic
CMR1 YDL156W Nuclear protein with role in transcription, protein quality control physical 1 1 1 Affinity Capture-MS
CMR1 YDL156W Nuclear protein with role in transcription, protein quality control genetic 1 1 1 Negative Genetic
MYO1 YHR023W Type II myosin heavy chain physical 1 1 1 Two-hybrid
CMD1 YBR109C Calmodulin genetic 1 1 1 Negative Genetic
MIS1 YBR084W Mitochondrial C1-tetrahydrofolate synthase genetic 1 1 1 Negative Genetic
ITC1 YGL133W Subunit of ATP-dependent Isw2p-Itc1p chromatin remodeling complex physical 1 1 1 Two-hybrid
IES5 YER092W Non-essential INO80 chromatin remodeling complex subunit genetic 1 1 1 Negative Genetic
IES1 YFL013C Subunit of the INO80 chromatin remodeling complex genetic 1 1 1 Negative Genetic
NIC96 YFR002W Linker nucleoporin component of the nuclear pore complex (NPC) genetic 1 1 1 Negative Genetic
POP2 YNR052C Subunit of Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation genetic 1 1 1 Synthetic Growth Defect
PPH3 YDR075W Catalytic subunit of protein phosphatase PP4 complex genetic 1 1 1 Positive Genetic
HTA1 YDR225W Histone H2A genetic 1 1 1 Negative Genetic
NUD1 YOR373W Mitotic exit network (MEN) scaffold protein genetic 1 1 1 Phenotypic Enhancement
PUB1 YNL016W Poly (A)+ RNA-binding protein physical 1 1 1 Affinity Capture-MS
MET18 YIL128W Component of cytosolic iron-sulfur protein assembly (CIA) machinery genetic 1 1 1 Negative Genetic
ILV1 YER086W Threonine deaminase, catalyzes first step in isoleucine biosynthesis genetic 1 1 1 Negative Genetic
DEP1 YAL013W Component of the Rpd3L histone deacetylase complex genetic 1 1 1 Negative Genetic
RPC53 YDL150W RNA polymerase III subunit C53 genetic 1 1 1 Negative Genetic
RTS1 YOR014W B-type regulatory subunit of protein phosphatase 2A (PP2A) genetic 1 1 1 Negative Genetic
OPI1 YHL020C Transcriptional regulator of a variety of genes genetic 1 1 1 Negative Genetic
PIL1 YGR086C Eisosome core component physical 1 1 1 Affinity Capture-MS
HOS4 YIL112W Subunit of the Set3 complex genetic 1 1 1 Synthetic Growth Defect
SDS3 YIL084C Component of the Rpd3L histone deacetylase complex genetic 1 1 1 Negative Genetic
CCT8 YJL008C Subunit of the cytosolic chaperonin Cct ring complex genetic 1 1 1 Negative Genetic
SNF5 YBR289W Subunit of the SWI/SNF chromatin remodeling complex genetic 1 1 1 Negative Genetic
NAT1 YDL040C Subunit of protein N-terminal acetyltransferase NatA genetic 1 1 1 Synthetic Growth Defect
SNU66 YOR308C Component of the U4/U6.U5 snRNP complex genetic 1 1 1 Negative Genetic
SGF73 YGL066W Subunit of DUBm module of SAGA and SLIK genetic 1 1 1 Negative Genetic
SRO9 YCL037C Cytoplasmic RNA-binding protein genetic 1 1 1 Positive Genetic
SRB8 YCR081W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
MSH4 YFL003C Protein involved in meiotic recombination genetic 1 1 1 Positive Genetic
SNU71 YGR013W Component of U1 snRNP required for mRNA splicing via spliceosome genetic 1 1 1 Dosage Growth Defect
ROM2 YLR371W Guanine nucleotide exchange factor (GEF) for Rho1p and Rho2p genetic 1 1 1 Positive Genetic
ACE2 YLR131C Transcription factor required for septum destruction after cytokinesis genetic 1 1 1 Negative Genetic
RPT4 YOR259C ATPase of the 19S regulatory particle of the 26S proteasome genetic 1 1 1 Positive Genetic
SNF7 YLR025W One of four subunits of the ESCRT-III complex physical 1 1 1 Two-hybrid
FIN1 YDR130C Spindle pole body-related intermediate filament protein genetic 1 1 1 Negative Genetic
IRA2 YOL081W GTPase-activating protein genetic 1 1 1 Negative Genetic
HYP2 YEL034W Translation elongation factor eIF-5A genetic 1 1 1 Positive Genetic
SER1 YOR184W 3-phosphoserine aminotransferase genetic 1 1 1 Negative Genetic
MGE1 YOR232W Mitochondrial matrix cochaperone physical 1 1 1 Two-hybrid
SAC6 YDR129C Fimbrin, actin-bundling protein genetic 1 1 1 Negative Genetic
BUD13 YGL174W Subunit of the RES complex genetic 1 1 1 Negative Genetic
ESL2 YKR096W hEST1A/B (SMG5/6)-like protein genetic 1 1 1 Negative Genetic
BFA1 YJR053W Subunit of a two-component GTPase-activating protein, Bfa1p-Bub2p genetic 1 1 1 Negative Genetic
APE1 YKL103C Vacuolar aminopeptidase yscI physical 1 1 1 Two-hybrid
SHP1 YBL058W UBX domain-containing substrate adaptor for Cdc48p genetic 1 1 1 Negative Genetic
RAD18 YCR066W E3 ubiquitin ligase genetic 1 1 1 Synthetic Growth Defect
CDC4 YFL009W F-box protein required for both the G1/S and G2/M phase transitions genetic 1 1 1 Negative Genetic
CTF13 YMR094W Subunit of the CBF3 complex genetic 1 1 1 Negative Genetic
ADD66 YKL206C Protein involved in 20S proteasome assembly genetic 1 1 1 Negative Genetic
HIR1 YBL008W Subunit of the HIR complex genetic 1 1 1 Synthetic Growth Defect
HOG1 YLR113W Mitogen-activated protein kinase involved in osmoregulation genetic 1 1 1 Synthetic Rescue
KEL2 YGR238C Protein that negatively regulates mitotic exit physical 1 1 1 Two-hybrid
RCK1 YGL158W Protein kinase involved in oxidative stress response physical 1 1 1 Affinity Capture-MS
SHS1 YDL225W Component of the septin ring that is required for cytokinesis genetic 1 1 1 Dosage Growth Defect
CIK1 YMR198W Kinesin-associated protein genetic 1 1 1 Positive Genetic
SWI5 YDR146C Transcription factor that recruits Mediator and Swi/Snf complexes genetic 1 1 1 Negative Genetic
PAC2 YER007W Microtubule effector required for tubulin heterodimer formation genetic 1 1 1 Negative Genetic
AHC1 YOR023C Subunit of the Ada histone acetyltransferase complex genetic 1 1 1 Negative Genetic
SWE1 YJL187C Protein kinase that regulates the G2/M transition genetic 1 1 1 Phenotypic Enhancement
UBR1 YGR184C E3 ubiquitin ligase (N-recognin) genetic 1 1 1 Negative Genetic
RTT103 YDR289C Protein involved in transcription termination by RNA polymerase II genetic 1 1 1 Negative Genetic
ELG1 YOR144C Subunit of an alternative replication factor C complex genetic 1 1 1 Synthetic Growth Defect
SPT2 YER161C Protein involved in negative regulation of transcription genetic 1 1 1 Negative Genetic
VPS21 YOR089C Endosomal Rab family GTPase genetic 1 1 1 Positive Genetic
MCK1 YNL307C Dual-specificity ser/thr and tyrosine protein kinase genetic 1 1 1 Negative Genetic
STE4 YOR212W G protein beta subunit physical 1 1 1 Two-hybrid
GCR2 YNL199C Transcriptional activator of genes involved in glycolysis genetic 1 1 1 Negative Genetic
CHZ1 YER030W Histone chaperone for Htz1p/H2A-H2B dimer genetic 1 1 1 Negative Genetic
UBC4 YBR082C Ubiquitin-conjugating enzyme (E2) genetic 1 1 1 Negative Genetic
SIR3 YLR442C Silencing protein genetic 1 1 1 Synthetic Rescue
ESS1 YJR017C Peptidylprolyl-cis/trans-isomerase (PPIase) genetic 1 1 1 Synthetic Growth Defect
SPC24 YMR117C Component of the kinetochore-associated Ndc80 complex genetic 1 1 1 Synthetic Lethality
CSM1 YCR086W Nucleolar protein that mediates homolog segregation during meiosis I genetic 1 1 1 Synthetic Growth Defect
AFT1 YGL071W Transcription factor involved in iron utilization and homeostasis genetic 1 1 1 Negative Genetic
HST3 YOR025W Sirtuin, histone H3 deacetylase genetic 1 1 1 Negative Genetic
MCM16 YPR046W Component of the Ctf19 complex and the COMA subcomplex genetic 1 1 1 Negative Genetic
GCN4 YEL009C bZIP transcriptional activator of amino acid biosynthetic genes physical 1 1 1 Two-hybrid
NUP57 YGR119C FG-nucleoporin component of central core of the nuclear pore complex physical 1 1 1 Two-hybrid
MND2 YIR025W Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 1 1 1 Negative Genetic
CSM3 YMR048W Replication fork associated factor genetic 1 1 1 Negative Genetic
RIM101 YHL027W Cys2His2 zinc-finger transcriptional repressor genetic 1 1 1 Negative Genetic
IME1 YJR094C Master regulator of meiosis that is active only during meiotic events genetic 1 1 1 Negative Genetic
CDC34 YDR054C Ubiquitin-conjugating enzyme (E2) genetic 1 1 1 Synthetic Lethality
BAS1 YKR099W Myb-related transcription factor genetic 1 1 1 Negative Genetic
SPC19 YDR201W Essential subunit of the Dam1 complex (aka DASH complex) physical 1 1 1 Two-hybrid
THI6 YPL214C Thiamine-phosphate diphosphorylase and hydroxyethylthiazole kinase genetic 1 1 1 Negative Genetic
VAM3 YOR106W Syntaxin-like vacuolar t-SNARE genetic 1 1 1 Positive Genetic
VIK1 YPL253C Protein that forms a kinesin-14 heterodimeric motor with Kar3p genetic 1 1 1 Negative Genetic
KEG1 YFR042W Integral membrane protein of the ER genetic 1 1 1 Negative Genetic
ASK10 YGR097W Regulator of the Fps1p glycerol channel genetic 1 1 1 Positive Genetic
ELP6 YMR312W Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex genetic 1 1 1 Negative Genetic
AIM4 YBR194W Protein proposed to be associated with the nuclear pore complex genetic 1 1 1 Negative Genetic
ELP3 YPL086C Subunit of Elongator complex genetic 1 1 1 Negative Genetic
RFT1 YBL020W Membrane protein required for translocation of Man5GlcNac2-PP-Dol genetic 1 1 1 Negative Genetic
BRF1 YGR246C TFIIIB B-related factor physical 1 1 1 Affinity Capture-MS
CET1 YPL228W RNA 5'-triphosphatase involved in mRNA 5' capping genetic 1 1 1 Negative Genetic
ARP6 YLR085C Actin-related protein that binds nucleosomes genetic 1 1 1 Positive Genetic
SWC5 YBR231C Component of the SWR1 complex genetic 1 1 1 Positive Genetic
IES3 YLR052W Subunit of the INO80 chromatin remodeling complex genetic 1 1 1 Negative Genetic
SFL1 YOR140W Transcriptional repressor and activator genetic 1 1 1 Negative Genetic
RTG3 YBL103C bHLH/Zip transcription factor for retrograde (RTG) and TOR pathways physical 1 1 1 Two-hybrid
VPS71 YML041C Nucleosome-binding component of the SWR1 complex genetic 1 1 1 Positive Genetic
KAR3 YPR141C Minus-end-directed microtubule motor genetic 1 1 1 Negative Genetic
MCM3 YEL032W Protein involved in DNA replication genetic 1 1 1 Positive Genetic
BIK1 YCL029C Microtubule-associated protein physical 1 1 1 Two-hybrid
SSN3 YPL042C Component of the RNA polymerase II mediator complex genetic 1 1 1 Positive Genetic
YET1 YKL065C Endoplasmic reticulum transmembrane protein physical 1 1 1 Two-hybrid
YLR031W YLR031W Putative protein of unknown function physical 1 1 1 Two-hybrid
YLR278C YLR278C Zinc-cluster protein genetic 1 1 1 Negative Genetic
YDL129W YDL129W Protein of unknown function genetic 1 1 1 Dosage Growth Defect
YKU70 YMR284W Subunit of the telomeric Ku complex (Yku70p-Yku80p) genetic 1 1 1 Negative Genetic
YBR220C YBR220C Putative protein of unknown function genetic 1 1 1 Negative Genetic
YER187W YER187W Putative protein of unknown function genetic 1 1 1 Negative Genetic
YHR050W-A YHR050W-A Protein of unknown function genetic 1 1 1 Negative Genetic
YJL070C YJL070C Putative metallo-dependent hydrolase superfamily protein genetic 1 1 1 Negative Genetic
YOL159C-A YOL159C-A Protein of unknown function genetic 1 1 1 Negative Genetic
BBP1 YPL255W Protein required for the spindle pole body (SPB) duplication genetic 1 1 1 Synthetic Lethality
SPC110 YDR356W Inner plaque spindle pole body (SPB) component physical 1 1 1 Two-hybrid
VPS60 YDR486C Protein involved in late endosome to vacuole transport physical 1 1 1 Two-hybrid
MPT5 YGL178W mRNA-binding protein of the PUF family physical 1 1 1 Affinity Capture-RNA
GAL80 YML051W Transcriptional regulator involved in the repression of GAL genes genetic 1 1 1 Positive Genetic
EMC1 YCL045C Member of conserved endoplasmic reticulum membrane complex genetic 1 1 1 Negative Genetic
CCS1 YMR038C Copper chaperone for superoxide dismutase Sod1p genetic 1 1 1 Synthetic Lethality
SPT10 YJL127C Histone H3 acetylase with a role in transcriptional regulation physical 1 1 1 Affinity Capture-MS
SPT10 YJL127C Histone H3 acetylase with a role in transcriptional regulation genetic 1 1 1 Synthetic Lethality
GAL1 YBR020W Galactokinase genetic 1 1 1 Negative Genetic
INP53 YOR109W Polyphosphatidylinositol phosphatase genetic 1 1 1 Negative Genetic
IVY1 YDR229W Phospholipid-binding protein that interacts with both Ypt7p and Vps33p physical 1 1 1 Two-hybrid
LRS4 YDR439W Nucleolar protein that forms a complex with Csm1p genetic 1 1 1 Synthetic Growth Defect
GAT1 YFL021W Transcriptional activator of nitrogen catabolite repression genes genetic 1 1 1 Dosage Rescue
HHT2 YNL031C Histone H3 genetic 1 1 1 Synthetic Growth Defect
ASH1 YKL185W Component of the Rpd3L histone deacetylase complex genetic 1 1 1 Negative Genetic
SWC3 YAL011W Protein of unknown function genetic 1 1 1 Positive Genetic
SUR1 YPL057C Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit genetic 1 1 1 Positive Genetic
SHE9 YDR393W Protein required for normal mitochondrial morphology physical 1 1 1 Two-hybrid
HAC1 YFL031W Basic leucine zipper (bZIP) transcription factor (ATF/CREB1 homolog) genetic 1 1 1 Negative Genetic
NUP188 YML103C Subunit of the inner ring of the nuclear pore complex (NPC) genetic 1 1 1 Synthetic Growth Defect
STV1 YMR054W Subunit a of the vacuolar-ATPase V0 domain physical 1 1 1 Two-hybrid
SGF11 YPL047W Integral subunit of SAGA histone acetyltransferase complex genetic 1 1 1 Synthetic Rescue
SSB1 YDL229W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Affinity Capture-MS
IXR1 YKL032C Transcriptional repressor that regulates hypoxic genes during normoxia genetic 1 1 1 Negative Genetic
MDM1 YML104C PtdIns-3-P binding protein that tethers the ER to vacuoles at NVJs physical 1 1 1 Two-hybrid
INH1 YDL181W Protein that inhibits ATP hydrolysis by the F1F0-ATP synthase physical 1 1 1 Two-hybrid
COY1 YKL179C Golgi membrane protein with similarity to mammalian CASP physical 1 1 1 Two-hybrid
TUP1 YCR084C General repressor of transcription in complex with Cyc8p physical 1 1 1 Two-hybrid
UBP8 YMR223W Ubiquitin-specific protease component of the SAGA acetylation complex genetic 1 1 1 Synthetic Rescue
SRS2 YJL092W DNA helicase and DNA-dependent ATPase genetic 1 1 1 Synthetic Growth Defect
NSI1 YDR026C RNA polymerase I termination factor genetic 1 1 1 Negative Genetic
UME6 YDR207C Rpd3L histone deacetylase complex subunit genetic 1 1 1 Negative Genetic
LCB5 YLR260W Minor sphingoid long-chain base kinase genetic 1 1 1 Negative Genetic
SEC28 YIL076W Epsilon-COP subunit of the coatomer genetic 1 1 1 Negative Genetic
RAD27 YKL113C 5' to 3' exonuclease, 5' flap endonuclease genetic 1 1 1 Synthetic Growth Defect
ELF1 YKL160W Transcription elongation factor with a conserved zinc finger domain genetic 1 1 1 Negative Genetic
SAC1 YKL212W Phosphatidylinositol phosphate phosphatase genetic 1 1 1 Negative Genetic
RTT109 YLL002W Histone acetyltransferase genetic 1 1 1 Synthetic Growth Defect
PKR1 YMR123W V-ATPase assembly factor genetic 1 1 1 Negative Genetic
IRC25 YLR021W Component of a heterodimeric Poc4p-Irc25p chaperone genetic 1 1 1 Positive Genetic
MRPL27 YBR282W Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
ERP5 YHR110W Protein with similarity to Emp24p and Erv25p physical 1 1 1 Two-hybrid
SLM3 YDL033C tRNA-specific 2-thiouridylase genetic 1 1 1 Positive Genetic
SMY1 YKL079W Kinesin-like myosin passenger-protein physical 1 1 1 Two-hybrid
ECM22 YLR228C Sterol regulatory element binding protein genetic 1 1 1 Negative Genetic
HUR1 YGL168W Protein with a role in DNA repair genetic 1 1 1 Negative Genetic
DOT5 YIL010W Nuclear thiol peroxidase genetic 1 1 1 Dosage Growth Defect
RIM13 YMR154C Calpain-like cysteine protease genetic 1 1 1 Negative Genetic
SLG1 YOR008C Sensor-transducer of the stress-activated PKC1-MPK1 kinase pathway genetic 1 1 1 Dosage Growth Defect
ERG4 YGL012W C-24(28) sterol reductase genetic 1 1 1 Negative Genetic
ITR1 YDR497C Myo-inositol transporter genetic 1 1 1 Negative Genetic
COS1 YNL336W Endosomal protein involved in turnover of plasma membrane proteins genetic 1 1 1 Negative Genetic
SIC1 YLR079W Cyclin-dependent kinase inhibitor (CKI) genetic 1 1 1 Positive Genetic
ERP6 YGL002W Member of the p24 family involved in ER to Golgi transport physical 1 1 1 Two-hybrid
GPI13 YLL031C ER membrane localized phosphoryltransferase genetic 1 1 1 Negative Genetic
BIG1 YHR101C Integral membrane protein of the endoplasmic reticulum genetic 1 1 1 Negative Genetic
FRT1 YOR324C Tail-anchored ER membrane protein of unknown function physical 1 1 1 Two-hybrid
RPI1 YIL119C Transcription factor, allelic differences between S288C and Sigma1278b physical 1 1 1 Two-hybrid
TRS65 YGR166W Component of transport protein particle (TRAPP) complex II genetic 1 1 1 Negative Genetic
OPI3 YJR073C Methylene-fatty-acyl-phospholipid synthase genetic 1 1 1 Negative Genetic
TMA17 YDL110C Regulatory gamma subunit of fatty acid synthase (FAS) genetic 1 1 1 Negative Genetic
LAM4 YHR080C Sterol-binding protein that localizes to puncta in the cortical ER physical 1 1 1 Two-hybrid
WWM1 YFL010C WW domain containing protein of unknown function genetic 1 1 1 Dosage Growth Defect
CMC2 YBL059C-A Protein involved in respiratory chain complex assembly or maintenance genetic 1 1 1 Negative Genetic
LNP1 YHR192W Lunapark family member involved in ER network formation physical 1 1 1 Two-hybrid
GPI8 YDR331W Catalytic subunit of the ER membrane GPI transamidase complex genetic 1 1 1 Negative Genetic
PIF1 YML061C DNA helicase, potent G-quadruplex DNA binder/unwinder genetic 1 1 1 Dosage Growth Defect
SLD3 YGL113W Protein involved in the initiation of DNA replication genetic 1 1 1 Synthetic Rescue
RCF1 YML030W Cytochrome c oxidase subunit genetic 1 1 1 Negative Genetic
TBS1 YBR150C Protein of unknown function genetic 1 1 1 Negative Genetic
SOM1 YEL059C-A Subunit of the mitochondrial inner membrane peptidase (IMP) genetic 1 1 1 Negative Genetic
VMS1 YDR049W Peptidyl-tRNA hydrolase that releases stalled peptides from ribosomes, genetic 1 1 1 Negative Genetic
MRX4 YPL168W Protein that associates with mitochondrial ribosome genetic 1 1 1 Negative Genetic
RMD9 YGL107C Mitochondrial protein that controls mitochondrial gene expression genetic 1 1 1 Negative Genetic
SRC1 YML034W Inner nuclear membrane protein genetic 1 1 1 Negative Genetic
VPH2 YKL119C Integral membrane protein required for V-ATPase function genetic 1 1 1 Negative Genetic
MTC6 YHR151C Protein of unknown function genetic 1 1 1 Positive Genetic
WHI2 YOR043W Negative regulator of TORC1 in response to limiting leucine genetic 1 1 1 Negative Genetic
TRM10 YOL093W tRNA methyltransferase genetic 1 1 1 Negative Genetic