Standard name Systematic name Name description Description
SPC110 YDR356W Inner plaque spindle pole body (SPB) component Inner plaque spindle pole body (SPB) component; gamma-tubulin small complex (gamma-TuSC) receptor that interacts with Spc98p to recruit the complex to the nuclear side of the SPB, connecting nuclear microtubules to the SPB; promotes gamma-TuSC assembly and oligomerization to initiate microtubule nucleation; interacts with Tub4p-complex and calmodulin; phosphorylated by Mps1p in cell cycle-dependent manner; ortholog of human pericentrin (kendrin)
Visualize the interactome of SPC110
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)
S 66

CYCLoPs localization & abundance

WT1 WT2 WT3
Nucleus 0.841 0.926 0.919
SpindlePole 0.071 NaN NaN
Mito NaN 0.099 0.268
Nucleolus NaN 0.086 NaN

GFP localization & abundance

GFP localization GFP abundance
spindle pole 279

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
SPC110 0 1 0 0 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
SPC42 YKL042W Central plaque component of spindle pole body (SPB) physical 13 6 10 Affinity Capture-Western, Affinity Capture-Western, Two-hybrid, FRET, Reconstituted Complex, Co-purification, FRET, FRET, Affinity Capture-MS, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid
CMD1 YBR109C Calmodulin physical 11 6 9 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Two-hybrid, FRET, Co-purification, Affinity Capture-Western, FRET, FRET, Reconstituted Complex
SPC29 YPL124W Inner plaque spindle pole body (SPB) component physical 11 5 7 Affinity Capture-Western, Reconstituted Complex, Two-hybrid, FRET, Co-purification, FRET, FRET, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid
TUB4 YLR212C Gamma-tubulin physical 11 5 6 Affinity Capture-Western, Reconstituted Complex, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Co-purification, FRET, FRET, Affinity Capture-Western, Reconstituted Complex
CMD1 YBR109C Calmodulin genetic 10 3 10 Dosage Rescue, Dosage Rescue, Dosage Rescue, Dosage Rescue, Dosage Rescue, Synthetic Rescue, Synthetic Rescue, Dosage Rescue, Negative Genetic, Synthetic Rescue
SPC97 YHR172W Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex physical 9 6 6 Affinity Capture-Western, Reconstituted Complex, Two-hybrid, Co-purification, Co-purification, FRET, FRET, Affinity Capture-MS, Affinity Capture-MS
SPC110 YDR356W Inner plaque spindle pole body (SPB) component physical 7 4 6 Affinity Capture-Western, Reconstituted Complex, Two-hybrid, Two-hybrid, FRET, Reconstituted Complex, Two-hybrid
SPC98 YNL126W Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex physical 6 4 5 Reconstituted Complex, Two-hybrid, Two-hybrid, Co-purification, Co-purification, FRET
CNM67 YNL225C Component of the spindle pole body outer plaque physical 5 3 4 Affinity Capture-Western, FRET, Co-purification, FRET, FRET
MLP2 YIL149C Myosin-like protein associated with the nuclear envelope physical 5 2 4 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
SPC97 YHR172W Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex genetic 5 2 3 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Dosage Lethality, Dosage Lethality
SPC29 YPL124W Inner plaque spindle pole body (SPB) component genetic 5 4 2 Dosage Lethality, Dosage Lethality, Synthetic Rescue, Dosage Rescue, Negative Genetic
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit physical 4 1 4 Biochemical Activity, Biochemical Activity, Biochemical Activity, Biochemical Activity
SPC98 YNL126W Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex genetic 4 2 3 Dosage Rescue, Dosage Rescue, Synthetic Lethality, Synthetic Lethality
BUB1 YGR188C Protein kinase involved in the cell cycle checkpoint into anaphase genetic 3 3 3 Synthetic Lethality, Synthetic Growth Defect, Negative Genetic
MPS1 YDL028C Dual-specificity kinase physical 3 2 3 Biochemical Activity, Affinity Capture-MS, Biochemical Activity
STU2 YLR045C Microtubule polymerase of the XMAP215/Dis1 family genetic 3 3 2 Synthetic Rescue, Phenotypic Suppression, Negative Genetic
CLB5 YPR120C B-type cyclin involved in DNA replication during S phase genetic 3 2 2 Phenotypic Suppression, Synthetic Rescue, Phenotypic Suppression
FKH1 YIL131C Forkhead family transcription factor regulation 2 2 2 chromatin immunoprecipitation-chip evidence, ChEC-Seq experiments
PAT1 YCR077C Deadenylation-dependent mRNA-decapping factor genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit genetic 2 2 2 Phenotypic Suppression, Negative Genetic
CTF18 YMR078C Subunit of a complex with Ctf8p genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
NUD1 YOR373W Mitotic exit network (MEN) scaffold protein physical 2 2 2 Affinity Capture-Western, Co-purification
CLB2 YPR119W B-type cyclin involved in cell cycle progression genetic 2 2 2 Synthetic Growth Defect, Phenotypic Suppression
BUB3 YOR026W Kinetochore checkpoint WD40 repeat protein genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
INO2 YDR123C Transcription factor genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
MAD2 YJL030W Component of the spindle-assembly checkpoint complex genetic 2 2 2 Phenotypic Enhancement, Synthetic Growth Defect
CHL1 YPL008W Probable DNA helicase genetic 2 2 2 Synthetic Lethality, Synthetic Growth Defect
ARP6 YLR085C Actin-related protein that binds nucleosomes genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
CTF8 YHR191C Subunit of a complex with Ctf18p genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
MAD1 YGL086W Coiled-coil protein involved in spindle-assembly checkpoint genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
TUB1 YML085C Alpha-tubulin physical 2 2 2 Co-purification, Co-localization
VIK1 YPL253C Protein that forms a kinesin-14 heterodimeric motor with Kar3p genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
VPS71 YML041C Nucleosome-binding component of the SWR1 complex genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
SWC3 YAL011W Protein of unknown function genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
EAF7 YNL136W Subunit of the NuA4 histone acetyltransferase complex genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
SLK19 YOR195W Kinetochore-associated protein genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
HCM1 YCR065W Forkhead transcription factor genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 2 1 2 Affinity Capture-RNA, Affinity Capture-RNA
DAM1 YGR113W Essential subunit of the Dam1 complex (aka DASH complex) genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
PKC1 YBL105C Protein serine/threonine kinase genetic 2 1 2 Dosage Rescue, Dosage Rescue
SLG1 YOR008C Sensor-transducer of the stress-activated PKC1-MPK1 kinase pathway genetic 2 1 2 Dosage Rescue, Dosage Rescue
ACT1 YFL039C Actin, structural protein in cytoskeleton genetic 2 2 1 Positive Genetic, Negative Genetic
CDC14 YFR028C Protein phosphatase required for mitotic exit physical 2 2 1 Affinity Capture-MS, Reconstituted Complex
MLP2 YIL149C Myosin-like protein associated with the nuclear envelope genetic 2 2 1 Phenotypic Enhancement, Dosage Growth Defect
SFI1 YLL003W Centrin (Cdc31p)-binding protein required for SPB duplication physical 2 2 1 Affinity Capture-Western, Affinity Capture-MS
TTI1 YKL033W Subunit of the ASTRA complex, involved in chromatin remodeling genetic 2 2 1 Negative Genetic, Positive Genetic
SPO12 YHR152W Nucleolar protein of unknown function genetic 2 2 1 Synthetic Rescue, Phenotypic Suppression
UBC5 YDR059C Ubiquitin-conjugating enzyme genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
IXR1 YKL032C Transcriptional repressor that regulates hypoxic genes during normoxia regulation 1 1 1 DNA to cDNA expression microarray evidence
GCR1 YPL075W Transcriptional activator of genes involved in glycolysis regulation 1 1 1 DNA to cDNA expression microarray evidence
SIN4 YNL236W Subunit of the RNA polymerase II mediator complex regulation 1 1 1 DNA to cDNA expression microarray evidence
ABF1 YKL112W DNA binding protein with possible chromatin-reorganizing activity regulation 1 1 1 DNA to cDNA expression microarray evidence
HSF1 YGL073W Trimeric heat shock transcription factor regulation 1 1 1 DNA to cDNA expression microarray evidence
GCN4 YEL009C bZIP transcriptional activator of amino acid biosynthetic genes regulation 1 1 1 DNA to cDNA expression microarray evidence
PGD1 YGL025C Subunit of the RNA polymerase II mediator complex regulation 1 1 1 DNA to cDNA expression microarray evidence
DOT6 YER088C Protein involved in rRNA and ribosome biogenesis regulation 1 1 1 DNA to cDNA expression microarray evidence
CTF19 YPL018W Outer kinetochore protein, needed for accurate chromosome segregation genetic 1 1 1 Synthetic Growth Defect
CTF3 YLR381W Outer kinetochore protein that forms a complex with Mcm16p and Mcm22p genetic 1 1 1 Synthetic Growth Defect
DSN1 YIR010W Essential component of the outer kinetochore MIND complex genetic 1 1 1 Negative Genetic
RPO21 YDL140C RNA polymerase II largest subunit B220 physical 1 1 1 Co-purification
IKI3 YLR384C Subunit of Elongator complex genetic 1 1 1 Negative Genetic
ESA1 YOR244W Catalytic subunit of the histone acetyltransferase complex (NuA4) physical 1 1 1 Affinity Capture-MS
EAF5 YEL018W Non-essential subunit of the NuA4 acetyltransferase complex genetic 1 1 1 Negative Genetic
RRP1 YDR087C Essential evolutionarily conserved nucleolar protein genetic 1 1 1 Negative Genetic
KAP123 YER110C Karyopherin beta genetic 1 1 1 Negative Genetic
MIA40 YKL195W Import and assembly protein in mitochondrial intermembrane space genetic 1 1 1 Positive Genetic
POP3 YNL282W Subunit of both RNase MRP and nuclear RNase P genetic 1 1 1 Negative Genetic
BRR2 YER172C RNA-dependent ATPase RNA helicase (DEIH box) genetic 1 1 1 Negative Genetic
NSE4 YDL105W Component of the SMC5-SMC6 complex genetic 1 1 1 Negative Genetic
POL5 YEL055C Protein involved in 60S assembly and pre-40S AFs recycling genetic 1 1 1 Negative Genetic
GUS1 YGL245W Glutamyl-tRNA synthetase (GluRS) genetic 1 1 1 Negative Genetic
PUS7 YOR243C Pseudouridine synthase genetic 1 1 1 Synthetic Growth Defect
RCK2 YLR248W Protein kinase involved in response to oxidative and osmotic stress physical 1 1 1 Affinity Capture-MS
LSM6 YDR378C Lsm (Like Sm) protein genetic 1 1 1 Synthetic Growth Defect
CDC48 YDL126C AAA ATPase with protein-unfoldase activity genetic 1 1 1 Negative Genetic
RPC82 YPR190C RNA polymerase III subunit C82 genetic 1 1 1 Negative Genetic
RPN6 YDL097C Essential, non-ATPase regulatory subunit of the 26S proteasome lid genetic 1 1 1 Negative Genetic
RPN8 YOR261C Essential non-ATPase regulatory subunit of the 26S proteasome genetic 1 1 1 Negative Genetic
RPT6 YGL048C ATPase of the 19S regulatory particle of the 26S proteasome genetic 1 1 1 Negative Genetic
GCD1 YOR260W Gamma subunit of the translation initiation factor eIF2B genetic 1 1 1 Negative Genetic
PRE10 YOR362C Alpha 7 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
PRE6 YOL038W Alpha 4 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
PRE7 YBL041W Beta 6 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
PRE8 YML092C Alpha 2 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-RNA
NAM7 YMR080C ATP-dependent RNA helicase of the SFI superfamily physical 1 1 1 Affinity Capture-RNA
REB1 YBR049C RNA polymerase I enhancer binding protein genetic 1 1 1 Negative Genetic
ACC1 YNR016C Acetyl-CoA carboxylase, biotin containing enzyme genetic 1 1 1 Negative Genetic
APC2 YLR127C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) physical 1 1 1 Co-purification
BNI1 YNL271C Formin genetic 1 1 1 Synthetic Growth Defect
CEG1 YGL130W Guanylyltransferase involved in mRNA 5' capping genetic 1 1 1 Negative Genetic
COP1 YDL145C Alpha subunit of COPI vesicle coatomer complex genetic 1 1 1 Positive Genetic
COX5A YNL052W Subunit Va of cytochrome c oxidase genetic 1 1 1 Synthetic Growth Defect
CDC16 YKL022C Subunit of the anaphase-promoting complex/cyclosome (APC/C) genetic 1 1 1 Negative Genetic
ELP2 YGR200C Subunit of Elongator complex genetic 1 1 1 Negative Genetic
ENP1 YBR247C Protein associated with U3 and U14 snoRNAs genetic 1 1 1 Negative Genetic
EAF3 YPR023C Component of the Rpd3S histone deacetylase complex genetic 1 1 1 Synthetic Growth Defect
FIP1 YJR093C Subunit of cleavage polyadenylation factor (CPF) genetic 1 1 1 Negative Genetic
FAP1 YNL023C Protein that binds to Fpr1p genetic 1 1 1 Synthetic Growth Defect
FRS1 YLR060W Beta subunit of cytoplasmic phenylalanyl-tRNA synthetase genetic 1 1 1 Negative Genetic
DYN1 YKR054C Cytoplasmic heavy chain dynein genetic 1 1 1 Synthetic Growth Defect
HHF1 YBR009C Histone H4 physical 1 1 1 Co-purification
HHF2 YNL030W Histone H4 physical 1 1 1 Co-purification
KRE33 YNL132W Acetyltransferase required for biogenesis of small ribosomal subunit genetic 1 1 1 Negative Genetic
LAS17 YOR181W Actin assembly factor genetic 1 1 1 Positive Genetic
CRM1 YGR218W Nuclear export factor, exportin physical 1 1 1 Two-hybrid
LSM7 YNL147W Lsm (Like Sm) protein genetic 1 1 1 Synthetic Growth Defect
MRP7 YNL005C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
MUM2 YBR057C Protein essential for meiotic DNA replication and sporulation physical 1 1 1 Two-hybrid
HTZ1 YOL012C Histone variant H2AZ genetic 1 1 1 Synthetic Growth Defect
NIC96 YFR002W Linker nucleoporin component of the nuclear pore complex (NPC) physical 1 1 1 Co-purification
NUP60 YAR002W FG-nucleoporin component of central core of the nuclear pore complex genetic 1 1 1 Synthetic Growth Defect
ORC2 YBR060C Subunit of the origin recognition complex (ORC) genetic 1 1 1 Negative Genetic
OST1 YJL002C Alpha subunit of the oligosaccharyltransferase complex of the ER lumen genetic 1 1 1 Negative Genetic
PAC10 YGR078C Part of the heteromeric co-chaperone GimC/prefoldin complex genetic 1 1 1 Synthetic Growth Defect
LAT1 YNL071W Dihydrolipoamide acetyltransferase component (E2) of the PDC genetic 1 1 1 Synthetic Growth Defect
PDA1 YER178W E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex genetic 1 1 1 Synthetic Growth Defect
GLE2 YER107C RNA export factor associated with the nuclear pore complex (NPC) genetic 1 1 1 Synthetic Growth Defect
PRP4 YPR178W Splicing factor genetic 1 1 1 Negative Genetic
INO4 YOL108C Transcription factor involved in phospholipid synthesis genetic 1 1 1 Synthetic Growth Defect
PTI1 YGR156W Essential component of CPF (cleavage and polyadenylation factor) genetic 1 1 1 Negative Genetic
MED8 YBR193C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
DEP1 YAL013W Component of the Rpd3L histone deacetylase complex genetic 1 1 1 Synthetic Growth Defect
RCO1 YMR075W Essential component of the Rpd3S histone deacetylase complex genetic 1 1 1 Synthetic Growth Defect
PUP3 YER094C Beta 3 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
RTS1 YOR014W B-type regulatory subunit of protein phosphatase 2A (PP2A) genetic 1 1 1 Synthetic Growth Defect
SCS2 YER120W Integral ER membrane protein, regulates phospholipid metabolism genetic 1 1 1 Negative Genetic
NUP85 YJR042W Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) physical 1 1 1 Co-purification
SEC63 YOR254C Essential subunit of Sec63 complex genetic 1 1 1 Negative Genetic
SEC66 YBR171W Non-essential subunit of Sec63 complex genetic 1 1 1 Negative Genetic
SIN3 YOL004W Component of both the Rpd3S and Rpd3L histone deacetylase complexes genetic 1 1 1 Synthetic Growth Defect
SIR2 YDL042C Conserved NAD+ dependent histone deacetylase of the Sirtuin family genetic 1 1 1 Synthetic Growth Defect
SLA1 YBL007C Cytoskeletal protein binding protein genetic 1 1 1 Synthetic Growth Defect
SMC3 YJL074C Subunit of the multiprotein cohesin complex genetic 1 1 1 Negative Genetic
BRR1 YPR057W snRNP protein component of spliceosomal snRNPs genetic 1 1 1 Negative Genetic
SAK1 YER129W Upstream serine/threonine kinase for the SNF1 complex physical 1 1 1 Affinity Capture-MS
RPT5 YOR117W ATPase of the 19S regulatory particle of the 26S proteasome genetic 1 1 1 Negative Genetic
MLP1 YKR095W Myosin-like protein associated with the nuclear envelope genetic 1 1 1 Dosage Growth Defect
SGV1 YPR161C Cyclin (Bur2p)-dependent protein kinase physical 1 1 1 Co-purification
SGV1 YPR161C Cyclin (Bur2p)-dependent protein kinase genetic 1 1 1 Positive Genetic
SBP1 YHL034C Protein that binds eIF4G and has a role in repression of translation physical 1 1 1 Affinity Capture-RNA
RRD2 YPL152W Peptidyl-prolyl cis/trans-isomerase genetic 1 1 1 Synthetic Growth Defect
RTS3 YGR161C Putative component of the protein phosphatase type 2A complex physical 1 1 1 Affinity Capture-MS
RPT4 YOR259C ATPase of the 19S regulatory particle of the 26S proteasome genetic 1 1 1 Negative Genetic
FES1 YBR101C Hsp70 (Ssa1p) nucleotide exchange factor genetic 1 1 1 Negative Genetic
PUF3 YLL013C Protein of the mitochondrial outer surface physical 1 1 1 Affinity Capture-RNA
SKI3 YPR189W Ski complex component and TPR protein genetic 1 1 1 Synthetic Growth Defect
CDC13 YDL220C Single stranded DNA-binding protein found at TG1-3 telomere G-tails physical 1 1 1 Co-purification
GAS1 YMR307W Beta-1,3-glucanosyltransferase required for cell wall assembly genetic 1 1 1 Positive Genetic
MMS2 YGL087C Ubiquitin-conjugating enzyme variant genetic 1 1 1 Synthetic Growth Defect
CDC5 YMR001C Polo-like kinase required for mitotic exit physical 1 1 1 Affinity Capture-Western
PPQ1 YPL179W Protein phosphatase that regulates the mating response genetic 1 1 1 Synthetic Growth Defect
BUB2 YMR055C Mitotic exit network regulator genetic 1 1 1 Synthetic Growth Defect
BFA1 YJR053W Subunit of a two-component GTPase-activating protein, Bfa1p-Bub2p genetic 1 1 1 Synthetic Growth Defect
LIA1 YJR070C Deoxyhypusine hydroxylase genetic 1 1 1 Negative Genetic
PDS1 YDR113C Securin genetic 1 1 1 Negative Genetic
HRT3 YLR097C Putative SCF-ubiquitin ligase F-box protein genetic 1 1 1 Synthetic Growth Defect
RNA1 YMR235C GTPase activating protein (GAP) for Gsp1p genetic 1 1 1 Negative Genetic
GYP5 YPL249C GTPase-activating protein (GAP) for yeast Rab family members physical 1 1 1 Two-hybrid
NTF2 YER009W Nuclear envelope protein genetic 1 1 1 Negative Genetic
PTC7 YHR076W Type 2C serine/threonine protein phosphatase (PP2C) physical 1 1 1 Co-purification
PPE1 YHR075C Protein with carboxyl methyl esterase activity genetic 1 1 1 Synthetic Growth Defect
HOG1 YLR113W Mitogen-activated protein kinase involved in osmoregulation genetic 1 1 1 Synthetic Growth Defect
KIN28 YDL108W Ser/Thr protein kinase and subunit of TFIIK, a TFIIH subassembly genetic 1 1 1 Negative Genetic
CIK1 YMR198W Kinesin-associated protein genetic 1 1 1 Synthetic Growth Defect
SKI2 YLR398C Ski complex component and putative RNA helicase genetic 1 1 1 Synthetic Growth Defect
AHC1 YOR023C Subunit of the Ada histone acetyltransferase complex genetic 1 1 1 Negative Genetic
PAP2 YOL115W Non-canonical poly(A) polymerase genetic 1 1 1 Synthetic Growth Defect
NUP2 YLR335W Nucleoporin involved in nucleocytoplasmic transport genetic 1 1 1 Synthetic Growth Defect
MCK1 YNL307C Dual-specificity ser/thr and tyrosine protein kinase genetic 1 1 1 Negative Genetic
MUS81 YDR386W Subunit of structure-specific Mms4p-Mus81p endonuclease physical 1 1 1 Affinity Capture-MS
MSG5 YNL053W Dual-specificity protein phosphatase physical 1 1 1 Affinity Capture-MS
GPA1 YHR005C Subunit of G protein involved in pheromone response physical 1 1 1 Affinity Capture-Western
AFG3 YER017C Mitochondrial inner membrane m-AAA protease component genetic 1 1 1 Negative Genetic
CDC43 YGL155W Beta subunit of geranylgeranyltransferase type I genetic 1 1 1 Negative Genetic
CIN4 YMR138W GTP-binding protein involved in beta-tubulin (Tub2p) folding genetic 1 1 1 Synthetic Growth Defect
MCM10 YIL150C Essential chromatin-associated protein genetic 1 1 1 Negative Genetic
BIM1 YER016W Microtubule plus end-tracking protein physical 1 1 1 Co-purification
BIM1 YER016W Microtubule plus end-tracking protein genetic 1 1 1 Negative Genetic
EBS1 YDR206W Protein involved in translation inhibition and nonsense-mediated decay genetic 1 1 1 Synthetic Growth Defect
MAD3 YJL013C Subunit of spindle-assembly checkpoint complex genetic 1 1 1 Synthetic Growth Defect
NDC80 YIL144W Component of the kinetochore-associated Ndc80 complex physical 1 1 1 Co-purification
NUF2 YOL069W Component of the kinetochore-associated Ndc80 complex physical 1 1 1 Co-purification
HSP10 YOR020C Mitochondrial matrix co-chaperonin genetic 1 1 1 Negative Genetic
NUP57 YGR119C FG-nucleoporin component of central core of the nuclear pore complex genetic 1 1 1 Negative Genetic
IKS1 YJL057C Protein kinase of unknown cellular role genetic 1 1 1 Synthetic Growth Defect
LAM6 YLR072W Sterol transporter that transfers sterols between membranes genetic 1 1 1 Synthetic Growth Defect
SAM35 YHR083W Component of the sorting and assembly machinery (SAM) complex genetic 1 1 1 Negative Genetic
ELP6 YMR312W Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex genetic 1 1 1 Negative Genetic
ELP3 YPL086C Subunit of Elongator complex genetic 1 1 1 Negative Genetic
ELP4 YPL101W Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex genetic 1 1 1 Negative Genetic
IKI1 YHR187W Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex genetic 1 1 1 Negative Genetic
NNF1 YJR112W Essential component of the outer kinetochore MIND complex physical 1 1 1 Two-hybrid
CET1 YPL228W RNA 5'-triphosphatase involved in mRNA 5' capping genetic 1 1 1 Negative Genetic
CDC31 YOR257W Calcium-binding component of the spindle pole body (SPB) half-bridge physical 1 1 1 Reconstituted Complex
CDC31 YOR257W Calcium-binding component of the spindle pole body (SPB) half-bridge genetic 1 1 1 Dosage Rescue
SAC3 YDR159W mRNA export factor genetic 1 1 1 Synthetic Growth Defect
SCL1 YGL011C Alpha 1 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
EPS1 YIL005W ER protein with chaperone and co-chaperone activity genetic 1 1 1 Synthetic Growth Defect
KAR3 YPR141C Minus-end-directed microtubule motor physical 1 1 1 Co-purification
KAR3 YPR141C Minus-end-directed microtubule motor genetic 1 1 1 Synthetic Growth Defect
KAR9 YPL269W Spindle positioning factor genetic 1 1 1 Synthetic Growth Defect
MPS1 YDL028C Dual-specificity kinase genetic 1 1 1 Negative Genetic
PUP1 YOR157C Beta 2 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
SKI7 YOR076C GTP-binding protein that couples the Ski complex and exosome genetic 1 1 1 Synthetic Growth Defect
MPS2 YGL075C Essential membrane protein localized at nuclear envelope and SPBs physical 1 1 1 Co-purification
NMD2 YHR077C Protein involved in the nonsense-mediated mRNA decay (NMD) pathway genetic 1 1 1 Synthetic Growth Defect
BBP1 YPL255W Protein required for the spindle pole body (SPB) duplication physical 1 1 1 Co-purification
JNM1 YMR294W Component of the yeast dynactin complex genetic 1 1 1 Synthetic Growth Defect
SFI1 YLL003W Centrin (Cdc31p)-binding protein required for SPB duplication genetic 1 1 1 Negative Genetic
TUB4 YLR212C Gamma-tubulin genetic 1 1 1 Synthetic Lethality
SPC34 YKR037C Essential subunit of the Dam1 complex (aka DASH complex) physical 1 1 1 Co-purification
SPC24 YMR117C Component of the kinetochore-associated Ndc80 complex physical 1 1 1 Co-purification
SPC25 YER018C Component of the kinetochore-associated Ndc80 complex physical 1 1 1 Co-purification
SPC19 YDR201W Essential subunit of the Dam1 complex (aka DASH complex) physical 1 1 1 Co-purification
STU1 YBL034C Microtubule plus-end-tracking non-motor protein physical 1 1 1 Co-purification
STU1 YBL034C Microtubule plus-end-tracking non-motor protein genetic 1 1 1 Negative Genetic
STU2 YLR045C Microtubule polymerase of the XMAP215/Dis1 family physical 1 1 1 Co-purification
TUB2 YFL037W Beta-tubulin physical 1 1 1 Co-purification
SPC72 YAL047C Gamma-tubulin small complex (gamma-TuSC) receptor physical 1 1 1 Co-purification
SSA1 YAL005C ATPase involved in protein folding and NLS-directed nuclear transport physical 1 1 1 Co-purification
SSB1 YDL229W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
SSK1 YLR006C Cytoplasmic phosphorelay intermediate osmosensor and regulator physical 1 1 1 Affinity Capture-MS
STE7 YDL159W Signal transducing MAP kinase kinase physical 1 1 1 Affinity Capture-MS
SWE1 YJL187C Protein kinase that regulates the G2/M transition physical 1 1 1 Affinity Capture-MS
SWE1 YJL187C Protein kinase that regulates the G2/M transition genetic 1 1 1 Phenotypic Suppression
TCO89 YPL180W Subunit of TORC1 (Tor1p or Tor2p-Kog1p-Lst8p-Tco89p) physical 1 1 1 Affinity Capture-MS
STE50 YCL032W Adaptor protein for various signaling pathways physical 1 1 1 Two-hybrid
YAF9 YNL107W Subunit of NuA4 histone H4 acetyltransferase and SWR1 complexes physical 1 1 1 Two-hybrid
TYE7 YOR344C Serine-rich protein that contains a bHLH DNA binding motif physical 1 1 1 Two-hybrid
TOP3 YLR234W DNA Topoisomerase III physical 1 1 1 Affinity Capture-MS
UFD2 YDL190C Ubiquitin (Ub) chain assembly factor (E4) genetic 1 1 1 Phenotypic Suppression
TEL2 YGR099W Subunit of the ASTRA complex, involved in chromatin remodeling genetic 1 1 1 Negative Genetic
UPF3 YGR072W Component of the nonsense-mediated mRNA decay (NMD) pathway genetic 1 1 1 Synthetic Growth Defect
TMC1 YOR052C AN1-type zinc finger protein, effector of proteotoxic stress response genetic 1 1 1 Synthetic Growth Defect
UBC4 YBR082C Ubiquitin-conjugating enzyme (E2) genetic 1 1 1 Synthetic Growth Defect
UBC7 YMR022W Ubiquitin conjugating enzyme genetic 1 1 1 Synthetic Growth Defect
YIL161W YIL161W Putative protein of unknown function genetic 1 1 1 Synthetic Growth Defect
YGR122W YGR122W Protein that may be involved in pH regulation genetic 1 1 1 Synthetic Growth Defect
UBC13 YDR092W E2 ubiquitin-conjugating enzyme genetic 1 1 1 Synthetic Growth Defect
SSE1 YPL106C ATPase component of heat shock protein Hsp90 chaperone complex genetic 1 1 1 Synthetic Growth Defect
TUB3 YML124C Alpha-tubulin genetic 1 1 1 Synthetic Growth Defect
SWC5 YBR231C Component of the SWR1 complex genetic 1 1 1 Synthetic Growth Defect
UBP2 YOR124C Ubiquitin-specific protease genetic 1 1 1 Synthetic Growth Defect
TIR3 YIL011W Cell wall mannoprotein genetic 1 1 1 Synthetic Growth Defect
YDJ1 YNL064C Type I HSP40 co-chaperone genetic 1 1 1 Synthetic Growth Defect
UME6 YDR207C Rpd3L histone deacetylase complex subunit genetic 1 1 1 Synthetic Growth Defect
YIP1 YGR172C Integral membrane protein genetic 1 1 1 Positive Genetic
SRP102 YKL154W Signal recognition particle (SRP) receptor beta subunit genetic 1 1 1 Positive Genetic
VPS8 YAL002W Membrane-binding component of the CORVET complex genetic 1 1 1 Positive Genetic
VMA9 YCL005W-A Vacuolar H+ ATPase subunit e of the V-ATPase V0 subcomplex genetic 1 1 1 Positive Genetic
VMA8 YEL051W Subunit D of the V1 peripheral membrane domain of V-ATPase genetic 1 1 1 Positive Genetic
VPS51 YKR020W Component of the GARP (Golgi-associated retrograde protein) complex genetic 1 1 1 Positive Genetic
TLG2 YOL018C Syntaxin-like t-SNARE genetic 1 1 1 Positive Genetic
SRB4 YER022W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
SRM1 YGL097W Nucleotide exchange factor for Gsp1p genetic 1 1 1 Negative Genetic
TFG2 YGR005C TFIIF (Transcription Factor II) middle subunit genetic 1 1 1 Negative Genetic
THS1 YIL078W Threonyl-tRNA synthetase genetic 1 1 1 Negative Genetic
TIM54 YJL054W Component of the mitochondrial TIM22 complex genetic 1 1 1 Negative Genetic
SSC1 YJR045C Hsp70 family ATPase genetic 1 1 1 Negative Genetic
UBA1 YKL210W Ubiquitin activating enzyme (E1) genetic 1 1 1 Negative Genetic
YHC1 YLR298C Component of the U1 snRNP complex required for pre-mRNA splicing genetic 1 1 1 Negative Genetic
TAD3 YLR316C Subunit of tRNA-specific adenosine-34 deaminase genetic 1 1 1 Negative Genetic
TIF34 YMR146C eIF3i subunit of the eukaryotic translation initiation factor 3 (eIF3) genetic 1 1 1 Negative Genetic
SUS1 YBR111W-A Global transcriptional regulator, component of SAGA, TREX-2 complexes genetic 1 1 1 Negative Genetic
UMP1 YBR173C Chaperone required for correct maturation of the 20S proteasome genetic 1 1 1 Negative Genetic
YDL218W YDL218W Putative protein of unknown function genetic 1 1 1 Negative Genetic
YCF1 YDR135C Vacuolar glutathione S-conjugate transporter genetic 1 1 1 Negative Genetic
YRB30 YGL164C RanGTP-binding protein genetic 1 1 1 Negative Genetic
UBA4 YHR111W E1-like protein that activates Urm1p before urmylation genetic 1 1 1 Negative Genetic
URM1 YIL008W Ubiquitin-like protein involved in thiolation of cytoplasmic tRNAs genetic 1 1 1 Negative Genetic
SSA2 YLL024C HSP70 family ATP-binding protein genetic 1 1 1 Negative Genetic
YOR072W-B YOR072W-B Putative protein of unknown function genetic 1 1 1 Negative Genetic
MPT5 YGL178W mRNA-binding protein of the PUF family physical 1 1 1 Affinity Capture-RNA
SLA2 YNL243W Adaptor protein that links actin to clathrin and endocytosis genetic 1 1 1 Positive Genetic
SMI1 YGR229C Protein involved in the regulation of cell wall synthesis genetic 1 1 1 Positive Genetic
DOT1 YDR440W Nucleosomal histone H3-Lys79 methylase genetic 1 1 1 Synthetic Growth Defect
MID2 YLR332W O-glycosylated plasma membrane protein genetic 1 1 1 Dosage Rescue
SNF3 YDL194W Plasma membrane low glucose sensor, regulates glucose transport genetic 1 1 1 Synthetic Growth Defect
NUP188 YML103C Subunit of the inner ring of the nuclear pore complex (NPC) genetic 1 1 1 Negative Genetic
DOM34 YNL001W Protein that facilitates ribosomal subunit dissociation physical 1 1 1 Co-purification
ERV14 YGL054C COPII-coated vesicle protein genetic 1 1 1 Positive Genetic
INP51 YIL002C Phosphatidylinositol 4,5-bisphosphate 5-phosphatase genetic 1 1 1 Negative Genetic
KIP1 YBL063W Kinesin-related motor protein physical 1 1 1 Co-purification
POM152 YMR129W Glycoprotein subunit of transmembrane ring of nuclear pore complex physical 1 1 1 Co-purification
POM152 YMR129W Glycoprotein subunit of transmembrane ring of nuclear pore complex genetic 1 1 1 Synthetic Growth Defect
PAC1 YOR269W Regulator of dynein, involved in intracellular transport genetic 1 1 1 Synthetic Growth Defect
RPL16B YNL069C Ribosomal 60S subunit protein L16B genetic 1 1 1 Synthetic Growth Defect
CFD1 YIL003W Highly conserved iron-sulfur cluster binding protein genetic 1 1 1 Negative Genetic
GPI2 YPL076W Protein involved in the synthesis of GlcNAc-PI genetic 1 1 1 Positive Genetic
SPC105 YGL093W Subunit of a kinetochore-microtubule binding complex physical 1 1 1 Co-purification
SPC105 YGL093W Subunit of a kinetochore-microtubule binding complex genetic 1 1 1 Negative Genetic
ERG7 YHR072W Lanosterol synthase genetic 1 1 1 Positive Genetic
ASE1 YOR058C Mitotic spindle midzone-localized microtubule bundling protein genetic 1 1 1 Synthetic Growth Defect
DCC1 YCL016C Subunit of a complex with Ctf8p and Ctf18p genetic 1 1 1 Negative Genetic
SCC4 YER147C Subunit of cohesin loading factor (Scc2p-Scc4p) genetic 1 1 1 Negative Genetic
CAB4 YGR277C Subunit of the CoA-Synthesizing Protein Complex (CoA-SPC) genetic 1 1 1 Negative Genetic
OCA4 YCR095C Cytoplasmic protein required for replication of Brome mosaic virus genetic 1 1 1 Synthetic Growth Defect
KIN4 YOR233W Serine/threonine protein kinase physical 1 1 1 Affinity Capture-MS
COA4 YLR218C Twin Cx(9)C protein involved in cytochrome c oxidase organization genetic 1 1 1 Negative Genetic
MRS2 YOR334W Mitochondrial inner membrane Mg(2+) channel genetic 1 1 1 Synthetic Growth Defect
APJ1 YNL077W Hsp40 chaperone with a role in SUMO-mediated protein degradation physical 1 1 1 Affinity Capture-MS
MNR2 YKL064W Vacuolar membrane protein required for magnesium homeostasis genetic 1 1 1 Negative Genetic
SCH9 YHR205W AGC family protein kinase genetic 1 1 1 Negative Genetic
PGA2 YNL149C Essential protein required for maturation of Gas1p and Pho8p genetic 1 1 1 Negative Genetic
SET4 YJL105W Chromatin-associated protein involved in control of stress response genetic 1 1 1 Negative Genetic
QCR8 YJL166W Subunit 8 of ubiquinol cytochrome-c reductase (Complex III) genetic 1 1 1 Negative Genetic
NCR1 YPL006W Vacuolar membrane protein involved with Npc2p in sterol trafficking genetic 1 1 1 Negative Genetic
MPS3 YJL019W Nuclear envelope protein genetic 1 1 1 Synthetic Lethality
DFG16 YOR030W Probable multiple transmembrane protein genetic 1 1 1 Negative Genetic
KIP3 YGL216W Kinesin-related antiparallel sliding motor protein genetic 1 1 1 Synthetic Growth Defect
SLI15 YBR156C Subunit of the conserved chromosomal passenger complex (CPC) genetic 1 1 1 Negative Genetic
MSA1 YOR066W Activator of G1-specific transcription factors MBF and SBF genetic 1 1 1 Synthetic Growth Defect
SND3 YBR106W Involved in SRP-independent protein targeting to the ER genetic 1 1 1 Synthetic Growth Defect
LGE1 YPL055C Protein involved in histone H2B ubiquitination physical 1 1 1 Affinity Capture-MS
LGE1 YPL055C Protein involved in histone H2B ubiquitination genetic 1 1 1 Synthetic Growth Defect
DYN3 YMR299C Dynein light intermediate chain (LIC) genetic 1 1 1 Synthetic Growth Defect
ERG3 YLR056W C-5 sterol desaturase genetic 1 1 1 Positive Genetic
QRI1 YDL103C UDP-N-acetylglucosamine pyrophosphorylase genetic 1 1 1 Negative Genetic
PFD1 YJL179W Subunit of heterohexameric prefoldin genetic 1 1 1 Negative Genetic
SAM37 YMR060C Component of the Sorting and Assembly Machinery (SAM) complex genetic 1 1 1 Synthetic Growth Defect
NCS2 YNL119W Protein required for uridine thiolation of Lys(UUU) and Glu(UUC) tRNAs genetic 1 1 1 Synthetic Growth Defect
NCS6 YGL211W Protein required for uridine thiolation of Gln, Lys, and Glu tRNAs genetic 1 1 1 Negative Genetic
GPI10 YGL142C Integral membrane protein involved in GPI anchor synthesis genetic 1 1 1 Positive Genetic
AGC1 YPR021C Mitochondrial amino acid transporter genetic 1 1 1 Negative Genetic
CHM7 YJL049W Yeast homolog of human CHMP7, localizes to the endoplasmic reticulum physical 1 1 1 Two-hybrid
PSD1 YNL169C Phosphatidylserine decarboxylase of the mitochondrial inner membrane genetic 1 1 1 Synthetic Growth Defect
PDR16 YNL231C Phosphatidylinositol transfer protein (PITP) genetic 1 1 1 Synthetic Growth Defect
SEI1 YLR404W Seipin involved in lipid droplet (LD) assembly genetic 1 1 1 Synthetic Growth Defect
PPM1 YDR435C Carboxyl methyltransferase genetic 1 1 1 Synthetic Growth Defect