Standard name Systematic name Name description Description
YDJ1 YNL064C Type I HSP40 co-chaperone Type I HSP40 co-chaperone; involved in regulation of HSP90 and HSP70 functions; acts as an adaptor that helps Rsp5p recognize cytosolic misfolded proteins for ubiquitination after heat shock; critical for determining cell size at Start as a function of growth rate; involved in protein translocation across membranes; member of the DnaJ family; chimeric protein in which human p58IPK J domain replaces yeast Ydj1p J domain can complement yeast ydj1 mutant
Visualize the interactome of YDJ1
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm NaN 0.906 0.848
ER NaN NaN 0.057

GFP localization & abundance

GFP localization GFP abundance
cytoplasm, nucleus 119000

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
YDJ1 3 0 0 0 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
SSA1 YAL005C ATPase involved in protein folding and NLS-directed nuclear transport physical 16 6 15 Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Biochemical Activity, Co-fractionation, Co-purification, Biochemical Activity, Biochemical Activity, Affinity Capture-MS, Affinity Capture-MS, Reconstituted Complex, Affinity Capture-MS, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-MS, Reconstituted Complex
HSP82 YPL240C Hsp90 chaperone physical 7 5 7 Affinity Capture-Western, Two-hybrid, Co-purification, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Reconstituted Complex
SIS1 YNL007C Type II HSP40 co-chaperone that interacts with the HSP70 protein Ssa1p genetic 7 4 7 Synthetic Lethality, Dosage Rescue, Dosage Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Phenotypic Enhancement
STI1 YOR027W Evolutionarily-conserved Hsp90 cochaperone genetic 6 2 5 Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SSA1 YAL005C ATPase involved in protein folding and NLS-directed nuclear transport genetic 5 4 5 Phenotypic Enhancement, Synthetic Lethality, Dosage Rescue, Phenotypic Enhancement, Dosage Growth Defect
GET3 YDL100C Guanine nucleotide exchange factor for Gpa1p genetic 5 2 4 Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic
GET4 YOR164C Protein involved in inserting tail-anchored proteins into ER membranes genetic 5 2 4 Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
POL32 YJR043C Third subunit of DNA polymerase delta genetic 5 2 4 Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic
RUD3 YOR216C Golgi matrix protein genetic 5 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
YDJ1 YNL064C Type I HSP40 co-chaperone physical 4 4 4 Co-crystal Structure, PCA, Reconstituted Complex, Affinity Capture-MS
SSE1 YPL106C ATPase component of heat shock protein Hsp90 chaperone complex genetic 4 3 4 Dosage Rescue, Dosage Rescue, Synthetic Lethality, Negative Genetic
CDC37 YDR168W Essential Hsp90p co-chaperone genetic 4 3 4 Negative Genetic, Dosage Rescue, Synthetic Lethality, Negative Genetic
MDY2 YOL111C Protein involved in inserting tail-anchored proteins into ER membranes genetic 4 2 4 Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic
RET2 YFR051C Delta subunit of the coatomer complex (COPI) genetic 4 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
TOR1 YJR066W PIK-related protein kinase and rapamycin target genetic 4 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
GET2 YER083C Subunit of the GET complex genetic 4 2 3 Negative Genetic, Synthetic Lethality, Negative Genetic, Negative Genetic
OST3 YOR085W Gamma subunit of the oligosaccharyltransferase complex of the ER lumen genetic 4 2 3 Positive Genetic, Positive Genetic, Positive Genetic, Negative Genetic
POL3 YDL102W Catalytic subunit of DNA polymerase delta genetic 4 2 3 Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic
BST1 YFL025C GPI inositol deacylase of the endoplasmic reticulum (ER) genetic 4 2 3 Positive Genetic, Positive Genetic, Positive Genetic, Negative Genetic
IRA2 YOL081W GTPase-activating protein genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
GET1 YGL020C Subunit of the GET complex genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
CDC7 YDL017W S/T kinase and catalytic subunit of DDK (Dbf4-dependent kinase) genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
RAD3 YER171W 5' to 3' DNA helicase genetic 4 4 2 Phenotypic Suppression, Synthetic Growth Defect, Synthetic Rescue, Negative Genetic
MCA1 YOR197W Ca2+-dependent cysteine protease genetic 4 3 1 Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Suppression
URE2 YNL229C Nitrogen catabolite repression transcriptional regulator genetic 3 3 3 Synthetic Lethality, Phenotypic Suppression, Negative Genetic
FKH1 YIL131C Forkhead family transcription factor regulation 3 2 3 chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation-chip evidence, ChEC-Seq experiments
SUP35 YDR172W Translation termination factor eRF3 physical 3 2 3 Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit genetic 3 2 3 Synthetic Lethality, Negative Genetic, Negative Genetic
BCY1 YIL033C Regulatory subunit of the cyclic AMP-dependent protein kinase (PKA) genetic 3 2 3 Negative Genetic, Negative Genetic, Positive Genetic
MPS1 YDL028C Dual-specificity kinase genetic 3 2 3 Synthetic Lethality, Negative Genetic, Negative Genetic
GPI19 YDR437W Subunit of GPI-GlcNAc transferase involved in synthesis of GlcNAc-PI genetic 3 2 3 Positive Genetic, Negative Genetic, Positive Genetic
MOT3 YMR070W Transcriptional repressor, activator genetic 3 2 3 Negative Genetic, Negative Genetic, Positive Genetic
SDS22 YKL193C Regulatory subunit of the type 1 protein phosphatase (PP1) Glc7p genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
THP2 YHR167W Subunit of the THO and TREX complexes genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
BEM1 YBR200W Protein containing SH3-domains genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
COP1 YDL145C Alpha subunit of COPI vesicle coatomer complex genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
CDC23 YHR166C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
RFC5 YBR087W Subunit of heteropentameric Replication factor C (RF-C) genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
CDC4 YFL009W F-box protein required for both the G1/S and G2/M phase transitions genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
WBP1 YEL002C Beta subunit of the oligosaccharyl transferase glycoprotein complex genetic 3 1 3 Positive Genetic, Positive Genetic, Positive Genetic
RAD52 YML032C Protein involved in homologous recombination genetic 3 3 2 Negative Genetic, Synthetic Growth Defect, Synthetic Rescue
ESA1 YOR244W Catalytic subunit of the histone acetyltransferase complex (NuA4) genetic 3 2 2 Synthetic Lethality, Synthetic Lethality, Negative Genetic
ROM2 YLR371W Guanine nucleotide exchange factor (GEF) for Rho1p and Rho2p genetic 3 2 2 Synthetic Lethality, Negative Genetic, Negative Genetic
LTE1 YAL024C Protein similar to GDP/GTP exchange factors genetic 3 2 2 Synthetic Lethality, Negative Genetic, Negative Genetic
BUB3 YOR026W Kinetochore checkpoint WD40 repeat protein genetic 3 2 2 Synthetic Lethality, Negative Genetic, Negative Genetic
DBP5 YOR046C Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family genetic 3 2 2 Synthetic Lethality, Synthetic Lethality, Negative Genetic
PAN1 YIR006C Part of actin cytoskeleton-regulatory complex Pan1p-Sla1p-End3p genetic 3 2 2 Positive Genetic, Negative Genetic, Positive Genetic
CSF1 YLR087C Protein with structural similarity to lipid transport protein Vps13p genetic 3 2 2 Negative Genetic, Negative Genetic, Positive Genetic
ALG6 YOR002W ER-luminal alpha 1,3 glucosyltransferase genetic 3 2 2 Positive Genetic, Positive Genetic, Negative Genetic
BIG1 YHR101C Integral membrane protein of the endoplasmic reticulum genetic 3 2 2 Positive Genetic, Negative Genetic, Positive Genetic
MTR4 YJL050W RNA duplex-sensing translocase genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
HGH1 YGR187C Chaperone protein for translation factor eEF2 genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
CTF18 YMR078C Subunit of a complex with Ctf8p genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
POL12 YBL035C B subunit of DNA polymerase alpha-primase complex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
LIN1 YHR156C Non-essential component of U5 snRNP genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
TAF5 YBR198C Subunit (90 kDa) of TFIID and SAGA complexes genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
CPR6 YLR216C Peptidyl-prolyl cis-trans isomerase (cyclophilin) genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
SER1 YOR184W 3-phosphoserine aminotransferase genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
PMA2 YPL036W Plasma membrane H+-ATPase genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
PDS1 YDR113C Securin genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
HOM6 YJR139C Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase) genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
SGT1 YOR057W Cochaperone protein genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
HOM3 YER052C Aspartate kinase (L-aspartate 4-P-transferase) genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
HOM2 YDR158W Aspartic beta semi-aldehyde dehydrogenase genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
BUD27 YFL023W Unconventional prefoldin protein involved in translation initiation genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
MMR1 YLR190W Phosphorylated protein of the mitochondrial outer membrane genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
CTF8 YHR191C Subunit of a complex with Ctf18p genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
SRO7 YPR032W Effector of Rab GTPase Sec4p genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
CPR7 YJR032W Peptidyl-prolyl cis-trans isomerase (cyclophilin) genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
NUP188 YML103C Subunit of the inner ring of the nuclear pore complex (NPC) genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
MOG1 YJR074W Conserved nuclear protein that interacts with GTP-Gsp1p genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
ORM2 YLR350W Protein that mediates sphingolipid homeostasis genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
AIM44 YPL158C Regulator of Cdc42p and Rho1p genetic 3 1 2 Positive Genetic, Positive Genetic, Positive Genetic
VAC14 YLR386W Enzyme regulator genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
SCS7 YMR272C Sphingolipid alpha-hydroxylase genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
ILM1 YJR118C Protein of unknown function genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
OPI3 YJR073C Methylene-fatty-acyl-phospholipid synthase genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
FMP30 YPL103C Protein with a role in maintaining mitochondrial morphology genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
SWF1 YDR126W Palmitoyltransferase that acts on transmembrane proteins genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
SEC72 YLR292C Non-essential subunit of Sec63 complex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
TSC11 YER093C Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p) genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
ECM8 YBR076W Non-essential protein of unknown function genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
SMC3 YJL074C Subunit of the multiprotein cohesin complex genetic 3 2 1 Positive Genetic, Negative Genetic, Negative Genetic
FKH2 YNL068C Forkhead family transcription factor regulation 2 2 2 chromatin immunoprecipitation-chip evidence, ChEC-Seq experiments
UTP21 YLR409C Subunit of U3-containing 90S preribosome and SSU processome complexes genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
CDC48 YDL126C AAA ATPase with protein-unfoldase activity genetic 2 2 2 Negative Genetic, Phenotypic Suppression
BET2 YPR176C Beta subunit of Type II geranylgeranyltransferase genetic 2 2 2 Negative Genetic, Positive Genetic
CDC10 YCR002C Component of the septin ring, required for cytokinesis genetic 2 2 2 Positive Genetic, Dosage Growth Defect
CDC12 YHR107C Component of the septin ring that is required for cytokinesis genetic 2 2 2 Positive Genetic, Dosage Growth Defect
FKS1 YLR342W Catalytic subunit of 1,3-beta-D-glucan synthase genetic 2 2 2 Synthetic Growth Defect, Synthetic Lethality
ESP1 YGR098C Separase/separin, a caspase-like cysteine protease genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 2 2 2 Affinity Capture-RNA, Affinity Capture-MS
HSC82 YMR186W Cytoplasmic chaperone of the Hsp90 family physical 2 2 2 Affinity Capture-MS, Reconstituted Complex
HSC82 YMR186W Cytoplasmic chaperone of the Hsp90 family genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
HSP82 YPL240C Hsp90 chaperone genetic 2 2 2 Synthetic Lethality, Synthetic Growth Defect
VPS52 YDR484W Component of the GARP (Golgi-associated retrograde protein) complex genetic 2 2 2 Negative Genetic, Positive Genetic
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes genetic 2 2 2 Negative Genetic, Phenotypic Enhancement
MSI1 YBR195C Subunit of chromatin assembly factor I (CAF-1) genetic 2 2 2 Positive Genetic, Negative Genetic
SIS1 YNL007C Type II HSP40 co-chaperone that interacts with the HSP70 protein Ssa1p physical 2 2 2 Co-localization, Affinity Capture-MS
TUB4 YLR212C Gamma-tubulin genetic 2 2 2 Synthetic Lethality, Synthetic Growth Defect
SSA2 YLL024C HSP70 family ATP-binding protein physical 2 2 2 Affinity Capture-MS, Reconstituted Complex
SSA2 YLL024C HSP70 family ATP-binding protein genetic 2 2 2 Synthetic Lethality, Negative Genetic
HAC1 YFL031W Basic leucine zipper (bZIP) transcription factor (ATF/CREB1 homolog) genetic 2 2 2 Negative Genetic, Dosage Rescue
MSS4 YDR208W Phosphatidylinositol-4-phosphate 5-kinase genetic 2 2 2 Synthetic Lethality, Negative Genetic
CAJ1 YER048C Nuclear type II J heat shock protein of the E. coli dnaJ family genetic 2 2 2 Negative Genetic, Dosage Rescue
SGT2 YOR007C Glutamine-rich cytoplasmic cochaperone genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
SWA2 YDR320C Auxilin-like protein involved in vesicular transport genetic 2 2 2 Dosage Rescue, Positive Genetic
SVP26 YHR181W ER exit adaptor for Golgi mannosyltransferases genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
SLG1 YOR008C Sensor-transducer of the stress-activated PKC1-MPK1 kinase pathway genetic 2 2 2 Dosage Rescue, Negative Genetic
CNE1 YAL058W Calnexin genetic 2 2 2 Synthetic Growth Defect, Positive Genetic
POP3 YNL282W Subunit of both RNase MRP and nuclear RNase P genetic 2 1 2 Negative Genetic, Negative Genetic
POP4 YBR257W Subunit of both RNase MRP and nuclear RNase P genetic 2 1 2 Negative Genetic, Negative Genetic
CWC23 YGL128C Component of a complex containing Cef1p genetic 2 1 2 Dosage Rescue, Dosage Rescue
SNU114 YKL173W GTPase component of U5 snRNP involved in mRNA splicing via spliceosome genetic 2 1 2 Negative Genetic, Negative Genetic
XRN1 YGL173C Evolutionarily-conserved 5'-3' exonuclease genetic 2 1 2 Negative Genetic, Negative Genetic
LSM1 YJL124C Lsm (Like Sm) protein genetic 2 1 2 Negative Genetic, Negative Genetic
PAT1 YCR077C Deadenylation-dependent mRNA-decapping factor genetic 2 1 2 Negative Genetic, Negative Genetic
RPO31 YOR116C RNA polymerase III largest subunit C160 genetic 2 1 2 Negative Genetic, Negative Genetic
RPN11 YFR004W Metalloprotease subunit of 19S regulatory particle physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
BMS1 YPL217C GTPase required for ribosomal subunit synthesis and rRNA processing genetic 2 1 2 Negative Genetic, Negative Genetic
ABD1 YBR236C Methyltransferase genetic 2 1 2 Negative Genetic, Negative Genetic
ARP2 YDL029W Essential component of the Arp2/3 complex genetic 2 1 2 Negative Genetic, Negative Genetic
CYR1 YJL005W Adenylate cyclase genetic 2 1 2 Negative Genetic, Negative Genetic
DOA1 YKL213C WD-repeat protein involved in ubiquitin-mediated protein degradation genetic 2 1 2 Negative Genetic, Negative Genetic
ELP2 YGR200C Subunit of Elongator complex genetic 2 1 2 Negative Genetic, Negative Genetic
ENP1 YBR247C Protein associated with U3 and U14 snoRNAs genetic 2 1 2 Negative Genetic, Negative Genetic
COG3 YER157W Essential component of the conserved oligomeric Golgi complex genetic 2 1 2 Negative Genetic, Negative Genetic
FAB1 YFR019W 1-phosphatidylinositol-3-phosphate 5-kinase genetic 2 1 2 Negative Genetic, Negative Genetic
FAS2 YPL231W Alpha subunit of fatty acid synthetase genetic 2 1 2 Negative Genetic, Negative Genetic
ORC2 YBR060C Subunit of the origin recognition complex (ORC) genetic 2 1 2 Negative Genetic, Negative Genetic
GIM5 YML094W Subunit of the heterohexameric cochaperone prefoldin complex genetic 2 1 2 Negative Genetic, Negative Genetic
PRE4 YFR050C Beta 7 subunit of the 20S proteasome genetic 2 1 2 Negative Genetic, Negative Genetic
PRP28 YDR243C Pre-mRNA splicing factor genetic 2 1 2 Negative Genetic, Negative Genetic
PSE1 YMR308C Karyopherin/importin that interacts with the nuclear pore complex genetic 2 1 2 Negative Genetic, Negative Genetic
RAD3 YER171W 5' to 3' DNA helicase physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
RFX1 YLR176C Major transcriptional repressor of DNA-damage-regulated genes genetic 2 1 2 Negative Genetic, Negative Genetic
SEC27 YGL137W Essential beta'-coat protein of the COPI coatomer genetic 2 1 2 Negative Genetic, Negative Genetic
HEM13 YDR044W Coproporphyrinogen III oxidase genetic 2 1 2 Negative Genetic, Negative Genetic
RTS3 YGR161C Putative component of the protein phosphatase type 2A complex genetic 2 1 2 Negative Genetic, Negative Genetic
RPT4 YOR259C ATPase of the 19S regulatory particle of the 26S proteasome genetic 2 1 2 Negative Genetic, Negative Genetic
VPS29 YHR012W Subunit of the membrane-associated retromer complex genetic 2 1 2 Negative Genetic, Negative Genetic
ASA1 YPR085C Subunit of the ASTRA complex, involved in chromatin remodeling genetic 2 1 2 Negative Genetic, Negative Genetic
PBS2 YJL128C MAP kinase kinase of the HOG signaling pathway genetic 2 1 2 Negative Genetic, Negative Genetic
DUN1 YDL101C Cell-cycle checkpoint S/T protein kinase genetic 2 1 2 Negative Genetic, Negative Genetic
HSP104 YLL026W Disaggregase physical 2 1 2 Reconstituted Complex, Reconstituted Complex
DOP1 YDR141C Protein involved in vesicular transport at trans-Golgi network (TGN) genetic 2 1 2 Negative Genetic, Negative Genetic
RNQ1 YCL028W [PIN(+)] prion physical 2 1 2 Affinity Capture-Western, Affinity Capture-Western
UBI4 YLL039C Ubiquitin genetic 2 1 2 Negative Genetic, Negative Genetic
SPO12 YHR152W Nucleolar protein of unknown function genetic 2 1 2 Negative Genetic, Negative Genetic
RNA1 YMR235C GTPase activating protein (GAP) for Gsp1p genetic 2 1 2 Negative Genetic, Negative Genetic
ERG6 YML008C Delta(24)-sterol C-methyltransferase genetic 2 1 2 Negative Genetic, Negative Genetic
CIN8 YEL061C Bipolar kinesin motor protein genetic 2 1 2 Negative Genetic, Negative Genetic
PTC7 YHR076W Type 2C serine/threonine protein phosphatase (PP2C) genetic 2 1 2 Negative Genetic, Negative Genetic
ECM33 YBR078W GPI-anchored protein involved in efficient glucose uptake genetic 2 1 2 Negative Genetic, Negative Genetic
VMA8 YEL051W Subunit D of the V1 peripheral membrane domain of V-ATPase genetic 2 1 2 Negative Genetic, Negative Genetic
ERG11 YHR007C Lanosterol 14-alpha-demethylase genetic 2 1 2 Negative Genetic, Negative Genetic
SNF4 YGL115W Activating gamma subunit of the AMP-activated Snf1p kinase complex genetic 2 1 2 Negative Genetic, Negative Genetic
RHO4 YKR055W Non-essential small GTPase genetic 2 1 2 Negative Genetic, Negative Genetic
NBP2 YDR162C Protein involved in the HOG (high osmolarity glycerol) pathway genetic 2 1 2 Positive Genetic, Positive Genetic
DUO1 YGL061C Essential subunit of the Dam1 complex (aka DASH complex) genetic 2 1 2 Positive Genetic, Positive Genetic
UBA4 YHR111W E1-like protein that activates Urm1p before urmylation genetic 2 1 2 Negative Genetic, Negative Genetic
KTI12 YKL110C Protein that plays a role in modification of tRNA wobble nucleosides genetic 2 1 2 Negative Genetic, Negative Genetic
APC5 YOR249C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 2 1 2 Negative Genetic, Negative Genetic
CDC27 YBL084C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 2 1 2 Negative Genetic, Negative Genetic
CDC26 YFR036W Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 2 1 2 Negative Genetic, Negative Genetic
TOR2 YKL203C PIK-related protein kinase and rapamycin target genetic 2 1 2 Negative Genetic, Negative Genetic
SCC2 YDR180W Subunit of cohesin loading factor (Scc2p-Scc4p) genetic 2 1 2 Negative Genetic, Negative Genetic
MBF1 YOR298C-A Transcriptional coactivator genetic 2 1 2 Negative Genetic, Negative Genetic
STE50 YCL032W Adaptor protein for various signaling pathways genetic 2 1 2 Negative Genetic, Negative Genetic
MET31 YPL038W Zinc-finger DNA-binding transcription factor genetic 2 1 2 Negative Genetic, Negative Genetic
MET32 YDR253C Zinc-finger DNA-binding transcription factor genetic 2 1 2 Negative Genetic, Negative Genetic
RGA2 YDR379W GTPase-activating protein for polarity-establishment protein Cdc42p genetic 2 1 2 Negative Genetic, Negative Genetic
PRP22 YER013W DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase genetic 2 1 2 Negative Genetic, Negative Genetic
MCA1 YOR197W Ca2+-dependent cysteine protease physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
CQD1 YPL109C UbiB family mitochondrial protein genetic 2 1 2 Negative Genetic, Negative Genetic
MDM31 YHR194W Mitochondrial protein that may have a role in phospholipid metabolism genetic 2 1 2 Negative Genetic, Negative Genetic
GAB1 YLR459W Subunit of the glycosylphosphatidylinositol transamidase complex genetic 2 1 2 Positive Genetic, Positive Genetic
ATP18 YML081C-A Subunit of the mitochondrial F1F0 ATP synthase genetic 2 1 2 Negative Genetic, Negative Genetic
CBS2 YDR197W Mitochondrial translational activator of the COB mRNA genetic 2 1 2 Negative Genetic, Negative Genetic
YDR124W YDR124W Mitochondrial protein of unknown function genetic 2 1 2 Negative Genetic, Negative Genetic
SPC105 YGL093W Subunit of a kinetochore-microtubule binding complex genetic 2 1 2 Negative Genetic, Negative Genetic
SEC11 YIR022W 18kDa catalytic subunit of the Signal Peptidase Complex (SPC) genetic 2 1 2 Positive Genetic, Positive Genetic
UME6 YDR207C Rpd3L histone deacetylase complex subunit genetic 2 1 2 Negative Genetic, Negative Genetic
SEC28 YIL076W Epsilon-COP subunit of the coatomer genetic 2 1 2 Negative Genetic, Negative Genetic
RAD27 YKL113C 5' to 3' exonuclease, 5' flap endonuclease genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
INM2 YDR287W Inositol monophosphatase genetic 2 1 2 Negative Genetic, Negative Genetic
TYS1 YGR185C Cytoplasmic tyrosyl-tRNA synthetase genetic 2 1 2 Negative Genetic, Negative Genetic
SVF1 YDR346C Protein with a potential role in cell survival pathways genetic 2 1 2 Negative Genetic, Negative Genetic
SYG1 YIL047C Plasma membrane protein of unknown function genetic 2 1 2 Negative Genetic, Negative Genetic
RKM4 YDR257C Ribosomal lysine methyltransferase genetic 2 1 2 Negative Genetic, Negative Genetic
QCR8 YJL166W Subunit 8 of ubiquinol cytochrome-c reductase (Complex III) genetic 2 1 2 Negative Genetic, Negative Genetic
SSM4 YIL030C Membrane-embedded ubiquitin-protein ligase and retrotranslocase genetic 2 1 2 Negative Genetic, Negative Genetic
SHE4 YOR035C Protein containing a UCS (UNC-45/CRO1/SHE4) domain genetic 2 1 2 Negative Genetic, Negative Genetic
ERG4 YGL012W C-24(28) sterol reductase genetic 2 1 2 Positive Genetic, Positive Genetic
HSP30 YCR021C Negative regulator of the H(+)-ATPase Pma1p genetic 2 1 2 Negative Genetic, Negative Genetic
TEL2 YGR099W Subunit of the ASTRA complex, involved in chromatin remodeling genetic 2 1 2 Negative Genetic, Negative Genetic
NCS6 YGL211W Protein required for uridine thiolation of Gln, Lys, and Glu tRNAs genetic 2 1 2 Negative Genetic, Negative Genetic
YBP2 YGL060W Central kinetochore associated protein genetic 2 1 2 Negative Genetic, Negative Genetic
CBP4 YGR174C Mitochondrial protein required for assembly of cytochrome bc1 complex genetic 2 1 2 Negative Genetic, Negative Genetic
ERG12 YMR208W Mevalonate kinase genetic 2 1 2 Negative Genetic, Negative Genetic
LAS21 YJL062W Mannose-ethanolamine phosphotransferase genetic 2 1 2 Negative Genetic, Negative Genetic
PTK1 YKL198C Putative serine/threonine protein kinase genetic 2 1 2 Negative Genetic, Negative Genetic
AIM33 YML087C Protein of unknown function, highly conserved across species genetic 2 1 2 Negative Genetic, Negative Genetic
PTH1 YHR189W One of two mitochondrially-localized peptidyl-tRNA hydrolases genetic 2 1 2 Negative Genetic, Negative Genetic
THR4 YCR053W Threonine synthase genetic 2 1 2 Negative Genetic, Negative Genetic
TRM9 YML014W tRNA methyltransferase genetic 2 1 2 Negative Genetic, Negative Genetic
SUT2 YPR009W Zn2Cys6 family transcription factor genetic 2 1 2 Negative Genetic, Negative Genetic
ACT1 YFL039C Actin, structural protein in cytoskeleton genetic 2 2 1 Positive Genetic, Negative Genetic
ARP3 YJR065C Essential component of the Arp2/3 complex genetic 2 2 1 Positive Genetic, Negative Genetic
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 2 2 1 Negative Genetic, Positive Genetic
MOB2 YFL034C-B Activator of Cbk1p kinase genetic 2 2 1 Positive Genetic, Negative Genetic
GPI16 YHR188C Subunit of the glycosylphosphatidylinositol transamidase complex genetic 2 2 1 Negative Genetic, Positive Genetic
MDY2 YOL111C Protein involved in inserting tail-anchored proteins into ER membranes physical 2 2 1 Affinity Capture-Western, Co-purification
PEP8 YJL053W Vacuolar protein component of the retromer genetic 2 2 1 Negative Genetic, Positive Genetic
GAL4 YPL248C DNA-binding transcription factor required for activating GAL genes physical 2 2 1 Affinity Capture-MS, Affinity Capture-Western
USO1 YDL058W Essential protein involved in vesicle-mediated ER to Golgi transport genetic 2 2 1 Negative Genetic, Positive Genetic
MTC1 YJL123C Protein of unknown function that may interact with ribosomes genetic 2 2 1 Positive Genetic, Negative Genetic
ALG14 YBR070C Component of UDP-GlcNAc transferase genetic 2 2 1 Negative Genetic, Positive Genetic
KRE1 YNL322C Cell wall glycoprotein involved in beta-glucan assembly genetic 2 2 1 Positive Genetic, Negative Genetic
TRS65 YGR166W Component of transport protein particle (TRAPP) complex II genetic 2 2 1 Negative Genetic, Positive Genetic
RCE1 YMR274C Type II CAAX prenyl protease genetic 2 2 1 Synthetic Rescue, Synthetic Growth Defect
RPA190 YOR341W RNA polymerase I largest subunit A190 genetic 2 1 1 Negative Genetic, Negative Genetic
PRT1 YOR361C eIF3b subunit of the eukaryotic translation initiation factor 3 (eIF3) physical 2 1 1 Affinity Capture-MS, Affinity Capture-MS
AAR2 YBL074C Component of the U5 snRNP complex genetic 2 1 1 Negative Genetic, Negative Genetic
CIA2 YHR122W Component of cytosolic iron-sulfur protein assembly (CIA) machinery genetic 2 1 1 Negative Genetic, Negative Genetic
LCB1 YMR296C Component of serine palmitoyltransferase genetic 2 1 1 Negative Genetic, Negative Genetic
ATG26 YLR189C UDP-glucose:sterol glucosyltransferase genetic 2 1 1 Positive Genetic, Positive Genetic
GEP3 YOR205C Protein required for mitochondrial ribosome small subunit biogenesis genetic 2 1 1 Positive Genetic, Positive Genetic
HTZ1 YOL012C Histone variant H2AZ genetic 2 1 1 Negative Genetic, Negative Genetic
NBP35 YGL091C Essential cytoplasmic iron-sulfur cluster binding protein genetic 2 1 1 Negative Genetic, Negative Genetic
IDH2 YOR136W Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase genetic 2 1 1 Negative Genetic, Negative Genetic
RPD3 YNL330C Histone deacetylase, component of both the Rpd3S and Rpd3L complexes genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
SRO9 YCL037C Cytoplasmic RNA-binding protein physical 2 1 1 Affinity Capture-Western, Affinity Capture-Western
SSE1 YPL106C ATPase component of heat shock protein Hsp90 chaperone complex physical 2 1 1 Affinity Capture-MS, Affinity Capture-MS
TLG2 YOL018C Syntaxin-like t-SNARE genetic 2 1 1 Negative Genetic, Negative Genetic
PIN4 YBL051C Protein involved in G2/M phase progression and response to DNA damage genetic 2 1 1 Negative Genetic, Negative Genetic
GAS1 YMR307W Beta-1,3-glucanosyltransferase required for cell wall assembly genetic 2 1 1 Negative Genetic, Negative Genetic
BEM4 YPL161C Protein involved in establishment of cell polarity and bud emergence genetic 2 1 1 Negative Genetic, Negative Genetic
UBC7 YMR022W Ubiquitin conjugating enzyme genetic 2 1 1 Negative Genetic, Negative Genetic
DBF2 YGR092W Ser/Thr kinase involved in transcription and stress response genetic 2 1 1 Negative Genetic, Negative Genetic
LEM3 YNL323W Membrane protein of the plasma membrane and ER genetic 2 1 1 Positive Genetic, Positive Genetic
HOF1 YMR032W F-BAR protein that regulates actin cytoskeleton organization genetic 2 1 1 Negative Genetic, Negative Genetic
TOP1 YOL006C Topoisomerase I physical 2 1 1 Affinity Capture-MS, Affinity Capture-MS
CEP3 YMR168C Essential kinetochore protein genetic 2 1 1 Negative Genetic, Negative Genetic
BRE5 YNR051C Ubiquitin protease cofactor genetic 2 1 1 Negative Genetic, Negative Genetic
DBF4 YDR052C Regulatory subunit of Cdc7p-Dbf4p kinase complex genetic 2 1 1 Negative Genetic, Negative Genetic
STN1 YDR082W Telomere end-binding and capping protein genetic 2 1 1 Negative Genetic, Negative Genetic
VPH1 YOR270C Subunit a of the vacuolar-ATPase V0 domain genetic 2 1 1 Negative Genetic, Negative Genetic
HSF1 YGL073W Trimeric heat shock transcription factor genetic 2 1 1 Negative Genetic, Negative Genetic
POL31 YJR006W Subunit of DNA polymerase delta (polymerase III) genetic 2 1 1 Negative Genetic, Negative Genetic
SUR1 YPL057C Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit genetic 2 1 1 Negative Genetic, Negative Genetic
VMA11 YPL234C Vacuolar ATPase V0 domain subunit c' genetic 2 1 1 Negative Genetic, Negative Genetic
RDS3 YPR094W Component of the SF3b subcomplex of the U2 snRNP genetic 2 1 1 Negative Genetic, Negative Genetic
SSB1 YDL229W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 2 1 1 Affinity Capture-MS, Affinity Capture-MS
HSP26 YBR072W Small heat shock protein (sHSP) with chaperone activity physical 2 1 1 Affinity Capture-MS, Affinity Capture-MS
CIT1 YNR001C Mitochondrial citrate synthase genetic 2 1 1 Negative Genetic, Negative Genetic
PIH1 YHR034C Component of the conserved R2TP complex (Rvb1-Rvb2-Tah1-Pih1) genetic 2 1 1 Negative Genetic, Negative Genetic
BCH2 YKR027W Member of the ChAPs (Chs5p-Arf1p-binding proteins) family genetic 2 1 1 Negative Genetic, Negative Genetic
YME1 YPR024W Catalytic subunit of i-AAA protease complex genetic 2 1 1 Positive Genetic, Positive Genetic
DCC1 YCL016C Subunit of a complex with Ctf8p and Ctf18p genetic 2 1 1 Negative Genetic, Negative Genetic
CRS1 YNL247W Cysteinyl-tRNA synthetase physical 2 1 1 Affinity Capture-MS, Affinity Capture-MS
SAC1 YKL212W Phosphatidylinositol phosphate phosphatase genetic 2 1 1 Negative Genetic, Negative Genetic
ARV1 YLR242C Cortical ER protein genetic 2 1 1 Negative Genetic, Negative Genetic
MSK1 YNL073W Mitochondrial lysine-tRNA synthetase physical 2 1 1 Affinity Capture-MS, Affinity Capture-MS
COX10 YPL172C Heme A:farnesyltransferase genetic 2 1 1 Negative Genetic, Negative Genetic
MDM32 YOR147W Mitochondrial inner membrane protein with similarity to Mdm31p genetic 2 1 1 Negative Genetic, Negative Genetic
ALG9 YNL219C Mannosyltransferase, involved in N-linked glycosylation genetic 2 1 1 Positive Genetic, Positive Genetic
PFA4 YOL003C Palmitoyltransferase with autoacylation activity genetic 2 1 1 Negative Genetic, Negative Genetic
PRD1 YCL057W Zinc metalloendopeptidase physical 2 1 1 Affinity Capture-Western, Affinity Capture-Western
CDC1 YDR182W Putative mannose-ethanolamine phosphate phosphodiesterase genetic 2 1 1 Positive Genetic, Positive Genetic
PSD1 YNL169C Phosphatidylserine decarboxylase of the mitochondrial inner membrane genetic 2 1 1 Negative Genetic, Negative Genetic
PGA3 YML125C Putative cytochrome b5 reductase, localized to the plasma membrane genetic 2 1 1 Negative Genetic, Negative Genetic
THI7 YLR237W Plasma membrane transporter responsible for the uptake of thiamine genetic 2 1 1 Negative Genetic, Negative Genetic
XDJ1 YLR090W Chaperone with a role in facilitating mitochondrial protein import genetic 2 1 1 Negative Genetic, Negative Genetic
SFP1 YLR403W Regulates transcription of ribosomal protein and biogenesis genes regulation 1 1 1 DNA to cDNA expression microarray evidence
CBF1 YJR060W Basic helix-loop-helix (bHLH) protein regulation 1 1 1 chromatin immunoprecipitation-chip evidence
YAP6 YDR259C Basic leucine zipper (bZIP) transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
HSF1 YGL073W Trimeric heat shock transcription factor regulation 1 1 1 DNA to cDNA expression microarray evidence
SPT3 YDR392W Subunit of the SAGA and SAGA-like transcriptional regulatory complexes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SPT6 YGR116W Nucleosome remodeling protein regulation 1 1 1 chromatin immunoprecipitation-chip evidence
AFT1 YGL071W Transcription factor involved in iron utilization and homeostasis regulation 1 1 1 DNA to cDNA expression microarray evidence
CLF1 YLR117C Member of the NineTeen Complex (NTC) genetic 1 1 1 Negative Genetic
CWC2 YDL209C Member of the NineTeen Complex (NTC) genetic 1 1 1 Negative Genetic
CWC25 YNL245C Splicing factor required for the first step of pre-mRNA splicing genetic 1 1 1 Negative Genetic
AME1 YBR211C Essential kinetochore protein associated with microtubules and SPBs genetic 1 1 1 Positive Genetic
DSN1 YIR010W Essential component of the outer kinetochore MIND complex physical 1 1 1 Affinity Capture-MS
CBF5 YLR175W Pseudouridine synthase catalytic subunit of box H/ACA snoRNPs genetic 1 1 1 Negative Genetic
NSL1 YPL233W Essential component of the MIND kinetochore complex physical 1 1 1 Affinity Capture-MS
RPB3 YIL021W RNA polymerase II third largest subunit B44 genetic 1 1 1 Negative Genetic
RPO21 YDL140C RNA polymerase II largest subunit B220 physical 1 1 1 Affinity Capture-MS
POB3 YML069W Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) genetic 1 1 1 Positive Genetic
CKB1 YGL019W Beta regulatory subunit of casein kinase 2 (CK2) genetic 1 1 1 Positive Genetic
MMS21 YEL019C Highly conserved SUMO E3 ligase subunit of SMC5-SMC6 complex genetic 1 1 1 Positive Genetic
NSE1 YLR007W Component of the SMC5-SMC6 complex genetic 1 1 1 Negative Genetic
NSE3 YDR288W Component of the SMC5-SMC6 complex genetic 1 1 1 Negative Genetic
IKI3 YLR384C Subunit of Elongator complex genetic 1 1 1 Negative Genetic
STT4 YLR305C Phosphatidylinositol-4-kinase genetic 1 1 1 Positive Genetic
NOG1 YPL093W Putative GTPase genetic 1 1 1 Negative Genetic
RPL10 YLR075W Ribosomal 60S subunit protein L10 genetic 1 1 1 Negative Genetic
RIC1 YLR039C Protein involved in retrograde transport to the cis-Golgi network genetic 1 1 1 Positive Genetic
POP5 YAL033W Subunit of both RNase MRP and nuclear RNase P genetic 1 1 1 Negative Genetic
RMP1 YLR145W Subunit of RNase MRP genetic 1 1 1 Negative Genetic
SPP382 YLR424W Essential protein that forms a dimer with Ntr2p genetic 1 1 1 Negative Genetic
NSE4 YDL105W Component of the SMC5-SMC6 complex genetic 1 1 1 Negative Genetic
NSE5 YML023C Component of the SMC5-SMC6 complex genetic 1 1 1 Negative Genetic
CDC42 YLR229C Small rho-like GTPase genetic 1 1 1 Negative Genetic
ARL1 YBR164C Soluble GTPase with a role in regulation of membrane traffic genetic 1 1 1 Positive Genetic
UTP10 YJL109C Nucleolar protein physical 1 1 1 Affinity Capture-MS
POL5 YEL055C Protein involved in 60S assembly and pre-40S AFs recycling genetic 1 1 1 Positive Genetic
DIP2 YLR129W Nucleolar protein genetic 1 1 1 Negative Genetic
UTP13 YLR222C Nucleolar protein genetic 1 1 1 Negative Genetic
GUS1 YGL245W Glutamyl-tRNA synthetase (GluRS) genetic 1 1 1 Negative Genetic
PUS7 YOR243C Pseudouridine synthase genetic 1 1 1 Negative Genetic
RAT1 YOR048C Nuclear 5' to 3' single-stranded RNA exonuclease genetic 1 1 1 Negative Genetic
LSM3 YLR438C-A Lsm (Like Sm) protein genetic 1 1 1 Negative Genetic
LSM6 YDR378C Lsm (Like Sm) protein genetic 1 1 1 Negative Genetic
DED1 YOR204W ATP-dependent DEAD-box RNA helicase with strand-annealing activity genetic 1 1 1 Negative Genetic
NPL3 YDR432W RNA-binding protein genetic 1 1 1 Synthetic Growth Defect
LRP1 YHR081W Nuclear exosome-associated nucleic acid binding protein genetic 1 1 1 Negative Genetic
RRP4 YHR069C Exosome non-catalytic core component genetic 1 1 1 Negative Genetic
RRP43 YCR035C Exosome non-catalytic core component genetic 1 1 1 Negative Genetic
RRP42 YDL111C Exosome non-catalytic core component genetic 1 1 1 Negative Genetic
RPB5 YBR154C RNA polymerase subunit ABC27 genetic 1 1 1 Negative Genetic
RET1 YOR207C Second-largest subunit of RNA polymerase III physical 1 1 1 Affinity Capture-MS
PSY2 YNL201C Subunit of protein phosphatase PP4 complex genetic 1 1 1 Negative Genetic
RPC82 YPR190C RNA polymerase III subunit C82 physical 1 1 1 Affinity Capture-MS
RPB7 YDR404C RNA polymerase II subunit B16 genetic 1 1 1 Positive Genetic
RPA43 YOR340C RNA polymerase I subunit A43 genetic 1 1 1 Negative Genetic
MFT1 YML062C Subunit of the THO complex genetic 1 1 1 Negative Genetic
SUB2 YDL084W Component of the TREX complex required for nuclear mRNA export genetic 1 1 1 Negative Genetic
GCD11 YER025W Gamma subunit of the translation initiation factor eIF2 genetic 1 1 1 Negative Genetic
RSC6 YCR052W Component of the RSC chromatin remodeling complex genetic 1 1 1 Positive Genetic
SIN4 YNL236W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
SRB2 YHR041C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Positive Genetic
TFC1 YBR123C Subunit of RNA polymerase III transcription initiation factor complex genetic 1 1 1 Negative Genetic
PWP1 YLR196W Protein with WD-40 repeats involved in rRNA processing genetic 1 1 1 Negative Genetic
RPN1 YHR027C Non-ATPase base subunit of the 19S RP of the 26S proteasome physical 1 1 1 Affinity Capture-MS
RPN10 YHR200W Proteasome polyubiquitin receptor physical 1 1 1 Affinity Capture-MS
RPN10 YHR200W Proteasome polyubiquitin receptor genetic 1 1 1 Positive Genetic
RPN5 YDL147W Subunit of the CSN and 26S proteasome lid complexes genetic 1 1 1 Negative Genetic
RPN12 YFR052W Subunit of the 19S regulatory particle of the 26S proteasome lid genetic 1 1 1 Positive Genetic
RPN8 YOR261C Essential non-ATPase regulatory subunit of the 26S proteasome genetic 1 1 1 Negative Genetic
RPN7 YPR108W Essential non-ATPase regulatory subunit of the 26S proteasome genetic 1 1 1 Negative Genetic
RPT1 YKL145W ATPase of the 19S regulatory particle of the 26S proteasome genetic 1 1 1 Negative Genetic
RPT6 YGL048C ATPase of the 19S regulatory particle of the 26S proteasome genetic 1 1 1 Negative Genetic
RPT3 YDR394W ATPase of the 19S regulatory particle of the 26S proteasome genetic 1 1 1 Negative Genetic
NIP1 YMR309C eIF3c subunit of the eukaryotic translation initiation factor 3 (eIF3) genetic 1 1 1 Negative Genetic
TIF34 YMR146C eIF3i subunit of the eukaryotic translation initiation factor 3 (eIF3) genetic 1 1 1 Negative Genetic
GCD1 YOR260W Gamma subunit of the translation initiation factor eIF2B genetic 1 1 1 Negative Genetic
KAP95 YLR347C Karyopherin beta genetic 1 1 1 Negative Genetic
RLI1 YDR091C Essential Fe-S protein genetic 1 1 1 Negative Genetic
MPE1 YKL059C Subunit of CPF cleavage and polyadenylation factor and E3 Ub-ligase genetic 1 1 1 Negative Genetic
CFT1 YDR301W RNA-binding subunit of the mRNA cleavage and polyadenylation factor genetic 1 1 1 Negative Genetic
RBG2 YGR173W Protein with a role in translation genetic 1 1 1 Negative Genetic
PRE10 YOR362C Alpha 7 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
PRE6 YOL038W Alpha 4 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
CDC39 YCR093W Subunit of the CCR4-NOT1 core complex genetic 1 1 1 Negative Genetic
ECM16 YMR128W Essential DEAH-box ATP-dependent RNA helicase specific to U3 snoRNP physical 1 1 1 Affinity Capture-MS
KAP104 YBR017C Transportin or cytosolic karyopherin beta 2 genetic 1 1 1 Negative Genetic
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-RNA
NUP82 YJL061W Linker nucleoporin component of the nuclear pore complex (NPC) genetic 1 1 1 Negative Genetic
RNT1 YMR239C Nuclear dsRNA-specific ribonuclease (RNase III) genetic 1 1 1 Negative Genetic
THS1 YIL078W Threonyl-tRNA synthetase genetic 1 1 1 Negative Genetic
HGH1 YGR187C Chaperone protein for translation factor eEF2 physical 1 1 1 Affinity Capture-MS
ARC40 YBR234C Subunit of the ARP2/3 complex genetic 1 1 1 Negative Genetic
ARO1 YDR127W Pentafunctional arom protein genetic 1 1 1 Negative Genetic
ASC1 YMR116C G-protein beta subunit and guanine dissociation inhibitor for Gpa2p physical 1 1 1 Affinity Capture-MS
CDC24 YAL041W Guanine nucleotide exchange factor (GEF) for Cdc42p genetic 1 1 1 Negative Genetic
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit physical 1 1 1 Affinity Capture-MS
CDC10 YCR002C Component of the septin ring, required for cytokinesis physical 1 1 1 Affinity Capture-Western
CDC11 YJR076C Component of the septin ring that is required for cytokinesis genetic 1 1 1 Dosage Growth Defect
CDC3 YLR314C Component of the septin ring that is required for cytokinesis genetic 1 1 1 Dosage Growth Defect
ERG26 YGL001C C-3 sterol dehydrogenase genetic 1 1 1 Positive Genetic
TIF6 YPR016C Constituent of 66S pre-ribosomal particles genetic 1 1 1 Negative Genetic
RIX1 YHR197W Component of the Rix1 complex and possibly pre-replicative complexes genetic 1 1 1 Negative Genetic
CEG1 YGL130W Guanylyltransferase involved in mRNA 5' capping genetic 1 1 1 Positive Genetic
AVO1 YOL078W Component of the membrane-bound TORC2 complex genetic 1 1 1 Negative Genetic
CLP1 YOR250C Component of the cleavage and polyadenylation factor I (CF I) genetic 1 1 1 Negative Genetic
DCP1 YOL149W Subunit of the Dcp1p-Dcp2p decapping enzyme complex genetic 1 1 1 Negative Genetic
ERO1 YML130C Thiol oxidase required for oxidative protein folding in the ER genetic 1 1 1 Positive Genetic
ERP2 YAL007C Member of the p24 family involved in ER to Golgi transport genetic 1 1 1 Positive Genetic
FRS1 YLR060W Beta subunit of cytoplasmic phenylalanyl-tRNA synthetase genetic 1 1 1 Negative Genetic
CCT4 YDL143W Subunit of the cytosolic chaperonin Cct ring complex genetic 1 1 1 Negative Genetic
GLO3 YER122C ADP-ribosylation factor GTPase activating protein (ARF GAP) genetic 1 1 1 Negative Genetic
GTR2 YGR163W Subunit of a TORC1-stimulating GTPase and the EGO/GSE complex genetic 1 1 1 Negative Genetic
ECM5 YMR176W Subunit of the Snt2C complex genetic 1 1 1 Negative Genetic
ARB1 YER036C ATPase of the ATP-binding cassette (ABC) family physical 1 1 1 Affinity Capture-MS
HSL1 YKL101W Nim1p-related protein kinase physical 1 1 1 Biochemical Activity
HSL1 YKL101W Nim1p-related protein kinase genetic 1 1 1 Positive Genetic
KRS1 YDR037W Lysyl-tRNA synthetase genetic 1 1 1 Positive Genetic
LAS17 YOR181W Actin assembly factor genetic 1 1 1 Negative Genetic
LCB2 YDR062W Component of serine palmitoyltransferase genetic 1 1 1 Negative Genetic
LSM2 YBL026W Lsm (Like Sm) protein genetic 1 1 1 Positive Genetic
MCM5 YLR274W Component of the Mcm2-7 hexameric helicase complex genetic 1 1 1 Negative Genetic
MCM6 YGL201C Protein involved in DNA replication genetic 1 1 1 Negative Genetic
MED1 YPR070W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
ADA2 YDR448W Transcription coactivator genetic 1 1 1 Negative Genetic
MOT1 YPL082C Essential protein involved in regulation of transcription genetic 1 1 1 Negative Genetic
MRP13 YGR084C Mitochondrial ribosomal protein of the small subunit genetic 1 1 1 Negative Genetic
MRP20 YDR405W Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Positive Genetic
MEC1 YBR136W Genome integrity checkpoint protein and PI kinase superfamily member genetic 1 1 1 Negative Genetic
CMD1 YBR109C Calmodulin genetic 1 1 1 Negative Genetic
ARP8 YOR141C Nuclear actin-related protein involved in chromatin remodeling genetic 1 1 1 Negative Genetic
NHP10 YDL002C Non-essential INO80 chromatin remodeling complex subunit genetic 1 1 1 Negative Genetic
ATG18 YFR021W Phosphoinositide binding protein genetic 1 1 1 Negative Genetic
NSP1 YJL041W FG-nucleoporin component of central core of the nuclear pore complex genetic 1 1 1 Positive Genetic
HSP42 YDR171W Small heat shock protein (sHSP) with chaperone activity genetic 1 1 1 Phenotypic Enhancement
ORC1 YML065W Largest subunit of the origin recognition complex physical 1 1 1 Affinity Capture-MS
PAC10 YGR078C Part of the heteromeric co-chaperone GimC/prefoldin complex genetic 1 1 1 Negative Genetic
PCF11 YDR228C mRNA 3' end processing factor genetic 1 1 1 Positive Genetic
PIM1 YBL022C ATP-dependent Lon protease genetic 1 1 1 Positive Genetic
PPH3 YDR075W Catalytic subunit of protein phosphatase PP4 complex genetic 1 1 1 Negative Genetic
CWC22 YGR278W Spliceosome-associated protein that is required for pre-mRNA splicing genetic 1 1 1 Negative Genetic
PRP6 YBR055C Splicing factor genetic 1 1 1 Negative Genetic
MDS3 YGL197W Putative component of the TOR regulatory pathway genetic 1 1 1 Negative Genetic
NRD1 YNL251C RNA-binding subunit of Nrd1 complex physical 1 1 1 Affinity Capture-RNA
PDC1 YLR044C Major of three pyruvate decarboxylase isozymes genetic 1 1 1 Negative Genetic
ILV1 YER086W Threonine deaminase, catalyzes first step in isoleucine biosynthesis genetic 1 1 1 Negative Genetic
RAD51 YER095W Strand exchange protein genetic 1 1 1 Negative Genetic
RFC3 YNL290W Subunit of heteropentameric Replication factor C (RF-C) genetic 1 1 1 Negative Genetic
FYV8 YGR196C Protein of unknown function genetic 1 1 1 Negative Genetic
RPB8 YOR224C RNA polymerase subunit ABC14.5 genetic 1 1 1 Negative Genetic
RCO1 YMR075W Essential component of the Rpd3S histone deacetylase complex genetic 1 1 1 Negative Genetic
SCS2 YER120W Integral ER membrane protein, regulates phospholipid metabolism genetic 1 1 1 Positive Genetic
PIL1 YGR086C Eisosome core component genetic 1 1 1 Positive Genetic
REA1 YLR106C Huge dynein-related AAA-type ATPase (midasin) genetic 1 1 1 Negative Genetic
RET3 YPL010W Zeta subunit of the coatomer complex (COPI) genetic 1 1 1 Negative Genetic
SEC26 YDR238C Essential beta-coat protein of the COPI coatomer genetic 1 1 1 Negative Genetic
SEC23 YPR181C GTPase-activating protein, stimulates the GTPase activity of Sar1p genetic 1 1 1 Negative Genetic
MNN10 YDR245W Subunit of a Golgi mannosyltransferase complex physical 1 1 1 Affinity Capture-MS
MNN10 YDR245W Subunit of a Golgi mannosyltransferase complex genetic 1 1 1 Negative Genetic
SEC66 YBR171W Non-essential subunit of Sec63 complex genetic 1 1 1 Negative Genetic
CSE1 YGL238W Nuclear envelope protein that acts as a recycling factor genetic 1 1 1 Negative Genetic
PHO12 YHR215W One of three repressible acid phosphatases genetic 1 1 1 Negative Genetic
RIE1 YGR250C RNA binding protein and negative regulator of START genetic 1 1 1 Negative Genetic
SET3 YKR029C Defining member of the SET3 histone deacetylase complex genetic 1 1 1 Positive Genetic
SIN3 YOL004W Component of both the Rpd3S and Rpd3L histone deacetylase complexes genetic 1 1 1 Negative Genetic
SKI6 YGR195W Exosome non-catalytic core component genetic 1 1 1 Negative Genetic
ECM25 YJL201W Endocytic site protein required for stress-induced cell elongation genetic 1 1 1 Negative Genetic
SLA1 YBL007C Cytoskeletal protein binding protein genetic 1 1 1 Negative Genetic
SEC17 YBL050W Alpha-SNAP cochaperone genetic 1 1 1 Positive Genetic
SLY1 YDR189W Hydrophilic protein involved in ER/Golgi vesicle trafficking genetic 1 1 1 Negative Genetic
SMC1 YFL008W Subunit of the multiprotein cohesin complex genetic 1 1 1 Negative Genetic
CCT8 YJL008C Subunit of the cytosolic chaperonin Cct ring complex genetic 1 1 1 Negative Genetic
RSE1 YML049C Protein involved in pre-mRNA splicing genetic 1 1 1 Negative Genetic
SAK1 YER129W Upstream serine/threonine kinase for the SNF1 complex genetic 1 1 1 Negative Genetic
SNF1 YDR477W AMP-activated S/T protein kinase genetic 1 1 1 Negative Genetic
SNF2 YOR290C Catalytic subunit of the SWI/SNF chromatin remodeling complex physical 1 1 1 Affinity Capture-MS
SNF2 YOR290C Catalytic subunit of the SWI/SNF chromatin remodeling complex genetic 1 1 1 Phenotypic Enhancement
NAT1 YDL040C Subunit of protein N-terminal acetyltransferase NatA genetic 1 1 1 Negative Genetic
RPT5 YOR117W ATPase of the 19S regulatory particle of the 26S proteasome physical 1 1 1 Affinity Capture-MS
RPT5 YOR117W ATPase of the 19S regulatory particle of the 26S proteasome genetic 1 1 1 Negative Genetic
SPN1 YPR133C Protein involved in RNA polymerase II transcription genetic 1 1 1 Positive Genetic
NGG1 YDR176W Subunit of chromatin modifying histone acetyltransferase complexes genetic 1 1 1 Negative Genetic
SEC65 YML105C Subunit of the signal recognition particle (SRP) genetic 1 1 1 Negative Genetic
SCP160 YJL080C Essential RNA-binding G protein effector of mating response pathway physical 1 1 1 Affinity Capture-MS
SGV1 YPR161C Cyclin (Bur2p)-dependent protein kinase genetic 1 1 1 Negative Genetic
SEN54 YPL083C Subunit of the tRNA splicing endonuclease genetic 1 1 1 Positive Genetic
TAF1 YGR274C TFIID subunit, involved in RNA pol II transcription initiation genetic 1 1 1 Negative Genetic
PTC1 YDL006W Type 2C protein phosphatase (PP2C) genetic 1 1 1 Positive Genetic
SPT8 YLR055C Subunit of the SAGA transcriptional regulatory complex genetic 1 1 1 Positive Genetic
TAF6 YGL112C Subunit (60 kDa) of TFIID and SAGA complexes genetic 1 1 1 Negative Genetic
PSK1 YAL017W PAS domain-containing serine/threonine protein kinase genetic 1 1 1 Negative Genetic
TAT1 YBR069C Amino acid transporter for valine, leucine, isoleucine, and tyrosine physical 1 1 1 Affinity Capture-MS
CAM1 YPL048W One of two isoforms of the gamma subunit of eEF1B genetic 1 1 1 Negative Genetic
SBP1 YHL034C Protein that binds eIF4G and has a role in repression of translation physical 1 1 1 Affinity Capture-RNA
NEW1 YPL226W Translation termination and ribosome biogenesis factor genetic 1 1 1 Negative Genetic
SCJ1 YMR214W One of several homologs of bacterial chaperone DnaJ genetic 1 1 1 Positive Genetic
TPK2 YPL203W cAMP-dependent protein kinase catalytic subunit genetic 1 1 1 Negative Genetic
BET5 YML077W Core component of transport protein particle (TRAPP) complexes I-III genetic 1 1 1 Positive Genetic
TRS130 YMR218C Component of transport protein particle (TRAPP) complex II genetic 1 1 1 Negative Genetic
BCK1 YJL095W MAPKKK acting in the protein kinase C signaling pathway genetic 1 1 1 Negative Genetic
ECM30 YLR436C Protein of unknown function genetic 1 1 1 Negative Genetic
RAV1 YJR033C Subunit of RAVE complex (Rav1p, Rav2p, Skp1p) genetic 1 1 1 Synthetic Growth Defect
VMA1 YDL185W Subunit A of the V1 peripheral membrane domain of V-ATPase genetic 1 1 1 Negative Genetic
VAM6 YDL077C Guanine nucleotide exchange factor for the GTPase Gtr1p physical 1 1 1 Affinity Capture-MS
VRP1 YLR337C Verprolin, proline-rich actin-associated protein genetic 1 1 1 Negative Genetic
SWP1 YMR149W Delta subunit of the oligosaccharyl transferase glycoprotein complex genetic 1 1 1 Positive Genetic
FLC2 YAL053W Putative calcium channel involved in calcium release under hypotonic genetic 1 1 1 Positive Genetic
RSM7 YJR113C Mitochondrial ribosomal protein of the small subunit genetic 1 1 1 Negative Genetic
FES1 YBR101C Hsp70 (Ssa1p) nucleotide exchange factor genetic 1 1 1 Negative Genetic
DIM1 YPL266W Essential 18S rRNA dimethylase (dimethyladenosine transferase) genetic 1 1 1 Negative Genetic
PUF3 YLL013C Protein of the mitochondrial outer surface physical 1 1 1 Affinity Capture-RNA
FAR8 YMR029C Protein involved in recovery from arrest in response to pheromone genetic 1 1 1 Positive Genetic
CSR2 YPR030W Nuclear ubiquitin protein ligase binding protein genetic 1 1 1 Negative Genetic
HYP2 YEL034W Translation elongation factor eIF-5A genetic 1 1 1 Positive Genetic
CAF20 YOR276W Phosphoprotein of the mRNA cap-binding complex physical 1 1 1 Affinity Capture-MS
PPQ1 YPL179W Protein phosphatase that regulates the mating response genetic 1 1 1 Negative Genetic
ATG31 YDR022C Autophagy-specific protein required for autophagosome formation genetic 1 1 1 Dosage Rescue
ARF1 YDL192W ADP-ribosylation factor physical 1 1 1 Affinity Capture-MS
SAC6 YDR129C Fimbrin, actin-bundling protein genetic 1 1 1 Negative Genetic
AHP1 YLR109W Thiol-specific peroxiredoxin genetic 1 1 1 Negative Genetic
GSP2 YOR185C GTP binding protein (mammalian Ranp homolog) genetic 1 1 1 Negative Genetic
GSF2 YML048W Endoplasmic reticulum (ER) localized integral membrane protein genetic 1 1 1 Positive Genetic
OYE2 YHR179W Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN) genetic 1 1 1 Negative Genetic
PMA1 YGL008C Plasma membrane P2-type H+-ATPase genetic 1 1 1 Positive Genetic
SEC53 YFL045C Phosphomannomutase genetic 1 1 1 Negative Genetic
BFA1 YJR053W Subunit of a two-component GTPase-activating protein, Bfa1p-Bub2p genetic 1 1 1 Negative Genetic
RGP1 YDR137W Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) genetic 1 1 1 Positive Genetic
CDC9 YDL164C DNA ligase I found in nucleus and mitochondria genetic 1 1 1 Negative Genetic
HXT7 YDR342C High-affinity glucose transporter physical 1 1 1 Affinity Capture-MS
SUI2 YJR007W Alpha subunit of the translation initiation factor eIF2 genetic 1 1 1 Negative Genetic
CYC8 YBR112C General transcriptional co-repressor physical 1 1 1 Affinity Capture-MS
CYC8 YBR112C General transcriptional co-repressor genetic 1 1 1 Dosage Rescue
ACS2 YLR153C Acetyl-coA synthetase isoform genetic 1 1 1 Negative Genetic
ILV3 YJR016C Dihydroxyacid dehydratase genetic 1 1 1 Positive Genetic
ERG10 YPL028W Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase) genetic 1 1 1 Negative Genetic
MET30 YIL046W F-box protein containing five copies of the WD40 motif genetic 1 1 1 Negative Genetic
CDC20 YGL116W Activator of anaphase-promoting complex/cyclosome (APC/C) genetic 1 1 1 Negative Genetic
KNS1 YLL019C Protein kinase involved in negative regulation of PolIII transcription genetic 1 1 1 Negative Genetic
SMC6 YLR383W Subunit of the SMC5-SMC6 complex physical 1 1 1 Affinity Capture-MS
SMC6 YLR383W Subunit of the SMC5-SMC6 complex genetic 1 1 1 Negative Genetic
SUV3 YPL029W ATP-dependent RNA helicase genetic 1 1 1 Negative Genetic
UFD2 YDL190C Ubiquitin (Ub) chain assembly factor (E4) genetic 1 1 1 Negative Genetic
UBI4 YLL039C Ubiquitin physical 1 1 1 Affinity Capture-MS
RSP5 YER125W NEDD4 family E3 ubiquitin ligase physical 1 1 1 Affinity Capture-Western
CDC60 YPL160W Cytosolic leucyl tRNA synthetase genetic 1 1 1 Positive Genetic
GRS1 YBR121C Cytoplasmic and mitochondrial glycyl-tRNA synthase genetic 1 1 1 Negative Genetic
ADH4 YGL256W Alcohol dehydrogenase isoenzyme type IV genetic 1 1 1 Negative Genetic
EST1 YLR233C TLC1 RNA-associated factor involved in telomere length regulation physical 1 1 1 Affinity Capture-MS
GPN3 YLR243W Putative GTPase with a role in biogenesis of RNA pol II and polIII genetic 1 1 1 Negative Genetic
GLE1 YDL207W Cytoplasmic nucleoporin required for polyadenylated mRNA export genetic 1 1 1 Negative Genetic
RSN1 YMR266W Membrane protein of unknown function genetic 1 1 1 Negative Genetic
NTF2 YER009W Nuclear envelope protein genetic 1 1 1 Negative Genetic
FRS2 YFL022C Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase genetic 1 1 1 Negative Genetic
RPP0 YLR340W Conserved ribosomal protein P0 of the ribosomal stalk genetic 1 1 1 Negative Genetic
ADD66 YKL206C Protein involved in 20S proteasome assembly genetic 1 1 1 Positive Genetic
BEM3 YPL115C Rho GTPase activating protein (RhoGAP) genetic 1 1 1 Positive Genetic
PTC7 YHR076W Type 2C serine/threonine protein phosphatase (PP2C) physical 1 1 1 Affinity Capture-MS
ARE1 YCR048W Acyl-CoA:sterol acyltransferase genetic 1 1 1 Positive Genetic
KSP1 YHR082C Serine/threonine protein kinase physical 1 1 1 Biochemical Activity
STE12 YHR084W Transcription factor that is activated by a MAPK signaling cascade physical 1 1 1 Affinity Capture-MS
HHT1 YBR010W Histone H3 genetic 1 1 1 Positive Genetic
DIA2 YOR080W Origin-binding F-box protein genetic 1 1 1 Synthetic Lethality
VPS35 YJL154C Endosomal subunit of membrane-associated retromer complex genetic 1 1 1 Positive Genetic
TMA108 YIL137C Ribosome-associated, nascent chain binding factor physical 1 1 1 Affinity Capture-MS
TMA108 YIL137C Ribosome-associated, nascent chain binding factor genetic 1 1 1 Negative Genetic
MEK1 YOR351C Meiosis-specific serine/threonine protein kinase genetic 1 1 1 Negative Genetic
CDC123 YLR215C Assembly factor for the eIF2 translation initiation factor complex genetic 1 1 1 Negative Genetic
SLT2 YHR030C Serine/threonine MAP kinase genetic 1 1 1 Negative Genetic
RCK1 YGL158W Protein kinase involved in oxidative stress response physical 1 1 1 Biochemical Activity
KIN28 YDL108W Ser/Thr protein kinase and subunit of TFIIK, a TFIIH subassembly genetic 1 1 1 Negative Genetic
ICP55 YER078C Mitochondrial aminopeptidase genetic 1 1 1 Negative Genetic
SWI5 YDR146C Transcription factor that recruits Mediator and Swi/Snf complexes genetic 1 1 1 Positive Genetic
ARF2 YDL137W ADP-ribosylation factor genetic 1 1 1 Positive Genetic
MIH1 YMR036C Protein tyrosine phosphatase genetic 1 1 1 Negative Genetic
OMS1 YDR316W Protein integral to the mitochondrial membrane genetic 1 1 1 Negative Genetic
AHC1 YOR023C Subunit of the Ada histone acetyltransferase complex genetic 1 1 1 Negative Genetic
HMG2 YLR450W HMG-CoA reductase physical 1 1 1 Affinity Capture-MS
VPS21 YOR089C Endosomal Rab family GTPase genetic 1 1 1 Positive Genetic
LSM8 YJR022W Lsm (Like Sm) protein genetic 1 1 1 Positive Genetic
RAD53 YPL153C DNA damage response kinase genetic 1 1 1 Negative Genetic
SAN1 YDR143C Ubiquitin-protein ligase physical 1 1 1 Affinity Capture-MS
MCM4 YPR019W Essential helicase component of heterohexameric MCM2-7 complexes genetic 1 1 1 Negative Genetic
EAP1 YKL204W eIF4E-associated protein, competes with eIF4G for binding to eIF4E genetic 1 1 1 Negative Genetic
BTN2 YGR142W v-SNARE binding protein genetic 1 1 1 Dosage Growth Defect
CIA1 YDR267C Component of cytosolic iron-sulfur protein assembly (CIA) machinery genetic 1 1 1 Negative Genetic
DEF1 YKL054C RNAPII degradation factor physical 1 1 1 Affinity Capture-MS
MUS81 YDR386W Subunit of structure-specific Mms4p-Mus81p endonuclease genetic 1 1 1 Negative Genetic
IST3 YIR005W Component of the U2 snRNP genetic 1 1 1 Negative Genetic
SKT5 YBL061C Activator of Chs3p (chitin synthase III) during vegetative growth genetic 1 1 1 Negative Genetic
FUS3 YBL016W Mitogen-activated serine/threonine protein kinase involved in mating genetic 1 1 1 Positive Genetic
RAD26 YJR035W Protein involved in transcription-coupled nucleotide excision repair genetic 1 1 1 Negative Genetic
PMI40 YER003C Mannose-6-phosphate isomerase genetic 1 1 1 Positive Genetic
MDH3 YDL078C Peroxisomal malate dehydrogenase genetic 1 1 1 Negative Genetic
GAL2 YLR081W Galactose permease genetic 1 1 1 Negative Genetic
BNA5 YLR231C Kynureninase genetic 1 1 1 Negative Genetic
JJJ1 YNL227C Co-chaperone that stimulates the ATPase activity of Ssa1p genetic 1 1 1 Dosage Rescue
PKH1 YDR490C Serine/threonine protein kinase genetic 1 1 1 Negative Genetic
RED1 YLR263W Protein component of the synaptonemal complex axial elements genetic 1 1 1 Negative Genetic
MMS22 YLR320W Subunit of E3 ubiquitin ligase complex involved in replication repair physical 1 1 1 Affinity Capture-MS
DHR2 YKL078W Predominantly nucleolar DEAH-box ATP-dependent RNA helicase genetic 1 1 1 Negative Genetic
MLP2 YIL149C Myosin-like protein associated with the nuclear envelope physical 1 1 1 Affinity Capture-MS
SPC24 YMR117C Component of the kinetochore-associated Ndc80 complex genetic 1 1 1 Negative Genetic
STE11 YLR362W Signal transducing MEK kinase physical 1 1 1 Reconstituted Complex
CUE5 YOR042W Ubiquitin-binding protein genetic 1 1 1 Negative Genetic
TVP23 YDR084C Integral membrane protein genetic 1 1 1 Negative Genetic
CDD1 YLR245C Cytidine deaminase genetic 1 1 1 Negative Genetic
CLN3 YAL040C G1 cyclin involved in cell cycle progression physical 1 1 1 Affinity Capture-Western
FAR3 YMR052W Protein of unknown function genetic 1 1 1 Positive Genetic
BNI4 YNL233W Targeting subunit for Glc7p protein phosphatase genetic 1 1 1 Negative Genetic
TRS85 YDR108W Component of transport protein particle (TRAPP) complex III genetic 1 1 1 Positive Genetic
GTR1 YML121W Subunit of a TORC1-stimulating GTPase and the EGO/GSE complex genetic 1 1 1 Negative Genetic
GDS1 YOR355W Protein involved in histone H4 acetylation at ribosomal protein genes genetic 1 1 1 Positive Genetic
IPK1 YDR315C Inositol 1,3,4,5,6-pentakisphosphate 2-kinase genetic 1 1 1 Negative Genetic
IRE1 YHR079C Serine-threonine kinase and endoribonuclease genetic 1 1 1 Synthetic Growth Defect
BIT61 YJL058C Subunit of TORC2 membrane-associated complex genetic 1 1 1 Negative Genetic
MAD2 YJL030W Component of the spindle-assembly checkpoint complex genetic 1 1 1 Negative Genetic
MSN5 YDR335W Karyopherin genetic 1 1 1 Negative Genetic
ASM4 YDL088C FG-nucleoporin component of central core of nuclear pore complex (NPC) genetic 1 1 1 Negative Genetic
HSP10 YOR020C Mitochondrial matrix co-chaperonin genetic 1 1 1 Positive Genetic
NUP57 YGR119C FG-nucleoporin component of central core of the nuclear pore complex genetic 1 1 1 Negative Genetic
NDL1 YLR254C Homolog of nuclear distribution factor NudE genetic 1 1 1 Negative Genetic
PKC1 YBL105C Protein serine/threonine kinase genetic 1 1 1 Negative Genetic
PRP5 YBR237W RNA helicase in the DEAD-box family genetic 1 1 1 Negative Genetic
GNP1 YDR508C Broad specificity amino acid permease genetic 1 1 1 Negative Genetic
CAK1 YFL029C Cyclin-dependent kinase-activating kinase genetic 1 1 1 Synthetic Lethality
SRL2 YLR082C Protein of unknown function genetic 1 1 1 Negative Genetic
ISY1 YJR050W Member of the NineTeen Complex (NTC) genetic 1 1 1 Negative Genetic
RBD2 YPL246C Possible rhomboid protease genetic 1 1 1 Positive Genetic
ADP1 YCR011C Putative ATP-dependent permease of the ABC transporter family genetic 1 1 1 Positive Genetic
SLM1 YIL105C Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm2p genetic 1 1 1 Negative Genetic
GPN2 YOR262W Putative GTPase with a specific role in RNA pol II and polIII biogenes genetic 1 1 1 Negative Genetic
URE2 YNL229C Nitrogen catabolite repression transcriptional regulator physical 1 1 1 Reconstituted Complex
ASK1 YKL052C Essential subunit of the Dam1 complex (aka DASH complex) genetic 1 1 1 Negative Genetic
COG4 YPR105C Essential component of the conserved oligomeric Golgi complex genetic 1 1 1 Negative Genetic
BOS1 YLR078C v-SNARE (vesicle specific SNAP receptor) physical 1 1 1 Reconstituted Complex
APC4 YDR118W Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 1 1 1 Negative Genetic
CWC15 YDR163W Non-essential protein involved in pre-mRNA splicing genetic 1 1 1 Negative Genetic
DOC1 YGL240W Processivity factor genetic 1 1 1 Negative Genetic
TFC4 YGR047C Subunit of RNA polymerase III transcription initiation factor complex genetic 1 1 1 Negative Genetic
RPS13 YDR064W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
BRF1 YGR246C TFIIIB B-related factor physical 1 1 1 Affinity Capture-MS
CET1 YPL228W RNA 5'-triphosphatase involved in mRNA 5' capping genetic 1 1 1 Positive Genetic
SMC2 YFR031C Subunit of the condensin complex genetic 1 1 1 Synthetic Lethality
SWR1 YDR334W Swi2/Snf2-related ATPase genetic 1 1 1 Negative Genetic
SWC5 YBR231C Component of the SWR1 complex genetic 1 1 1 Negative Genetic
RPP1 YHR062C Subunit of both RNase MRP and nuclear RNase P genetic 1 1 1 Negative Genetic
TAF8 YML114C TFIID subunit (65 kDa) genetic 1 1 1 Negative Genetic
IES3 YLR052W Subunit of the INO80 chromatin remodeling complex genetic 1 1 1 Negative Genetic
SWI1 YPL016W Subunit of the SWI/SNF chromatin remodeling complex genetic 1 1 1 Negative Genetic
HPC2 YBR215W Subunit of the HIR complex genetic 1 1 1 Positive Genetic
CBF1 YJR060W Basic helix-loop-helix (bHLH) protein genetic 1 1 1 Positive Genetic
MRS1 YIR021W Splicing protein genetic 1 1 1 Negative Genetic
RTG3 YBL103C bHLH/Zip transcription factor for retrograde (RTG) and TOR pathways genetic 1 1 1 Negative Genetic
RPS1A YLR441C Ribosomal protein of the small (40S) subunit physical 1 1 1 Affinity Capture-MS
RPS8A YBL072C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS8A YBL072C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
RPS17A YML024W Ribosomal protein 51 (rp51) of the small (40s) subunit physical 1 1 1 Affinity Capture-MS
RPS7A YOR096W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS22A YJL190C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
CSE4 YKL049C Centromeric histone H3-like protein physical 1 1 1 Affinity Capture-MS
SSC1 YJR045C Hsp70 family ATPase genetic 1 1 1 Positive Genetic
BFR1 YOR198C Component of mRNP complexes associated with polyribosomes physical 1 1 1 Affinity Capture-RNA
BRN1 YBL097W Subunit of the condensin complex genetic 1 1 1 Synthetic Lethality
CLC1 YGR167W Clathrin light chain genetic 1 1 1 Negative Genetic
HXK2 YGL253W Hexokinase isoenzyme 2 genetic 1 1 1 Positive Genetic
MCM3 YEL032W Protein involved in DNA replication genetic 1 1 1 Positive Genetic
MDM12 YOL009C Mitochondrial outer membrane protein, ERMES complex subunit genetic 1 1 1 Negative Genetic
MEX67 YPL169C Poly(A)RNA binding protein involved in nuclear mRNA export genetic 1 1 1 Negative Genetic
MYO5 YMR109W One of two type I myosin motors genetic 1 1 1 Negative Genetic
NRG1 YDR043C Transcriptional repressor genetic 1 1 1 Negative Genetic
CBF2 YGR140W Essential kinetochore protein genetic 1 1 1 Negative Genetic
OST2 YOR103C Epsilon subunit of the oligosaccharyltransferase complex genetic 1 1 1 Positive Genetic
SEC1 YDR164C Sm-like protein involved in docking and fusion of exocytic vesicles genetic 1 1 1 Negative Genetic
SEC20 YDR498C Membrane glycoprotein v-SNARE genetic 1 1 1 Negative Genetic
SEC61 YLR378C Conserved ER protein translocation channel physical 1 1 1 Affinity Capture-MS
SEC61 YLR378C Conserved ER protein translocation channel genetic 1 1 1 Positive Genetic
SSN3 YPL042C Component of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
STE6 YKL209C Plasma membrane ATP-binding cassette (ABC) transporter physical 1 1 1 Affinity Capture-Western
STU1 YBL034C Microtubule plus-end-tracking non-motor protein genetic 1 1 1 Negative Genetic
SWI4 YER111C DNA binding component of the SBF complex (Swi4p-Swi6p) genetic 1 1 1 Negative Genetic
TOM20 YGR082W Component of the TOM (translocase of outer membrane) complex physical 1 1 1 Reconstituted Complex
TOM22 YNL131W Component of the TOM (Translocase of Outer Membrane) complex physical 1 1 1 Affinity Capture-Western
TIP20 YGL145W Peripheral membrane protein required for COPI vesicle fusion to the ER genetic 1 1 1 Negative Genetic
PEP7 YDR323C Adaptor protein involved in vesicle-mediated vacuolar protein sorting genetic 1 1 1 Negative Genetic
FIG4 YNL325C Phosphatidylinositol 3,5-bisphosphate (PtdIns[3,5]P) phosphatase genetic 1 1 1 Negative Genetic
VAC17 YCL063W Phosphoprotein involved in vacuole inheritance genetic 1 1 1 Negative Genetic
YCG1 YDR325W Subunit of the condensin complex genetic 1 1 1 Synthetic Lethality
TRA1 YHR099W Subunit of SAGA and NuA4 histone acetyltransferase complexes genetic 1 1 1 Synthetic Growth Defect
ATG2 YNL242W Peripheral membrane protein required for autophagic vesicle formation genetic 1 1 1 Negative Genetic
IQG1 YPL242C Actin filament binding protein that enhances actin ring formation genetic 1 1 1 Negative Genetic
SEC16 YPL085W COPII vesicle coat protein required for ER transport vesicle budding genetic 1 1 1 Negative Genetic
GOS1 YHL031C v-SNARE protein involved in Golgi transport genetic 1 1 1 Negative Genetic
SPC110 YDR356W Inner plaque spindle pole body (SPB) component genetic 1 1 1 Synthetic Growth Defect
HAP1 YLR256W Zinc finger transcription factor physical 1 1 1 Affinity Capture-Western
KAR2 YJL034W ATPase involved in protein import into the ER genetic 1 1 1 Positive Genetic
OST6 YML019W Subunit of the oligosaccharyltransferase complex of the ER lumen genetic 1 1 1 Positive Genetic
HAP4 YKL109W Transcription factor genetic 1 1 1 Positive Genetic
GAL10 YBR019C UDP-glucose-4-epimerase genetic 1 1 1 Negative Genetic
SEC24 YIL109C Component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat genetic 1 1 1 Negative Genetic
SEC31 YDL195W Component of the Sec13p-Sec31p complex of the COPII vesicle coat genetic 1 1 1 Negative Genetic
MPT5 YGL178W mRNA-binding protein of the PUF family physical 1 1 1 Affinity Capture-RNA
SIL1 YOL031C Nucleotide exchange factor for the ER lumenal Hsp70 chaperone Kar2p genetic 1 1 1 Positive Genetic
VPS54 YDR027C Component of the GARP (Golgi-associated retrograde protein) complex genetic 1 1 1 Positive Genetic
CSG2 YBR036C Endoplasmic reticulum membrane protein genetic 1 1 1 Negative Genetic
SNL1 YIL016W Ribosome-associated protein genetic 1 1 1 Negative Genetic
SSA3 YBL075C ATPase involved in protein folding and the response to stress physical 1 1 1 Co-crystal Structure
SSA3 YBL075C ATPase involved in protein folding and the response to stress genetic 1 1 1 Synthetic Lethality
FCP1 YMR277W Carboxy-terminal domain (CTD) phosphatase genetic 1 1 1 Negative Genetic
VPS4 YPR173C AAA-ATPase involved in multivesicular body (MVB) protein sorting genetic 1 1 1 Synthetic Lethality
CHS3 YBR023C Chitin synthase III genetic 1 1 1 Negative Genetic
AKR1 YDR264C Palmitoyl transferase involved in protein palmitoylation genetic 1 1 1 Negative Genetic
MID2 YLR332W O-glycosylated plasma membrane protein genetic 1 1 1 Dosage Rescue
HKR1 YDR420W Mucin family member that functions as an osmosensor in the HOG pathway genetic 1 1 1 Synthetic Lethality
SIP3 YNL257C Putative sterol transfer protein genetic 1 1 1 Negative Genetic
SPC29 YPL124W Inner plaque spindle pole body (SPB) component genetic 1 1 1 Negative Genetic
SSA4 YER103W Heat shock protein that is highly induced upon stress physical 1 1 1 Reconstituted Complex
SSA4 YER103W Heat shock protein that is highly induced upon stress genetic 1 1 1 Synthetic Lethality
STU2 YLR045C Microtubule polymerase of the XMAP215/Dis1 family genetic 1 1 1 Negative Genetic
PBP1 YGR178C Component of glucose deprivation induced stress granules genetic 1 1 1 Negative Genetic
CLA4 YNL298W Cdc42p-activated signal transducing kinase genetic 1 1 1 Negative Genetic
RPL25 YOL127W Ribosomal 60S subunit protein L25 physical 1 1 1 Affinity Capture-MS
RPL31A YDL075W Ribosomal 60S subunit protein L31A physical 1 1 1 Affinity Capture-MS
ALG5 YPL227C UDP-glucose:dolichyl-phosphate glucosyltransferase genetic 1 1 1 Positive Genetic
VAC8 YEL013W Vacuole-specific Myo2p receptor genetic 1 1 1 Negative Genetic
PRI1 YIR008C Subunit of DNA primase genetic 1 1 1 Negative Genetic
COX17 YLL009C Copper metallochaperone that transfers copper to Sco1p and Cox11p genetic 1 1 1 Negative Genetic
SWC3 YAL011W Protein of unknown function genetic 1 1 1 Negative Genetic
AUR1 YKL004W Phosphatidylinositol:ceramide phosphoinositol transferase genetic 1 1 1 Positive Genetic
BSD2 YBR290W Heavy metal ion homeostasis protein genetic 1 1 1 Positive Genetic
TOM1 YDR457W E3 ubiquitin ligase of the hect-domain class physical 1 1 1 Affinity Capture-MS
RER1 YCL001W Protein involved in retention of membrane proteins genetic 1 1 1 Positive Genetic
HOC1 YJR075W Alpha-1,6-mannosyltransferase genetic 1 1 1 Negative Genetic
MNN11 YJL183W Subunit of a Golgi mannosyltransferase complex genetic 1 1 1 Negative Genetic
PMT1 YDL095W Protein O-mannosyltransferase of the ER membrane genetic 1 1 1 Positive Genetic
PXA1 YPL147W Subunit of heterodimeric peroxisomal ABC transport complex, with Pxa2p genetic 1 1 1 Negative Genetic
NVJ1 YHR195W Nuclear envelope protein genetic 1 1 1 Negative Genetic
RPS2 YGL123W Protein component of the small (40S) subunit physical 1 1 1 Affinity Capture-MS
RPS3 YNL178W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RIM20 YOR275C Protein involved in proteolytic activation of Rim101p genetic 1 1 1 Positive Genetic
ENT5 YDR153C Protein containing an N-terminal epsin-like domain genetic 1 1 1 Positive Genetic
CIN2 YPL241C GTPase-activating protein (GAP) for Cin4p genetic 1 1 1 Negative Genetic
TFB2 YPL122C Subunit of TFIIH and nucleotide excision repair factor 3 complexes genetic 1 1 1 Negative Genetic
BET4 YJL031C Alpha subunit of Type II geranylgeranyltransferase genetic 1 1 1 Negative Genetic
COX14 YML129C Mitochondrial cytochrome c oxidase (complex IV) assembly factor genetic 1 1 1 Negative Genetic
SYP1 YCR030C Negative regulator of WASP-Arp23 complex genetic 1 1 1 Dosage Rescue
RPN4 YDL020C Transcription factor that stimulates expression of proteasome genes genetic 1 1 1 Synthetic Lethality
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
EAF7 YNL136W Subunit of the NuA4 histone acetyltransferase complex genetic 1 1 1 Negative Genetic
RPS20 YHL015W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
PUP2 YGR253C Alpha 5 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
TFB4 YPR056W Subunit of TFIIH complex physical 1 1 1 Affinity Capture-MS
TFB5 YDR079C-A Component of RNA polymerase II general transcription factor TFIIH genetic 1 1 1 Negative Genetic
SYS1 YJL004C Integral membrane protein of the Golgi genetic 1 1 1 Positive Genetic
MOG1 YJR074W Conserved nuclear protein that interacts with GTP-Gsp1p physical 1 1 1 Affinity Capture-MS
RPS14A YCR031C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
TAO3 YIL129C Component of the RAM signaling network genetic 1 1 1 Positive Genetic
FOX2 YKR009C 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase genetic 1 1 1 Negative Genetic
RPS0A YGR214W Ribosomal 40S subunit protein S0A physical 1 1 1 Affinity Capture-MS
RPS18A YDR450W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
PET127 YOR017W Protein with a role in 5'-end processing of mitochondrial RNAs genetic 1 1 1 Negative Genetic
DPM1 YPR183W Dolichol phosphate mannose (Dol-P-Man) synthase of ER membrane genetic 1 1 1 Negative Genetic
RTN1 YDR233C Reticulon protein genetic 1 1 1 Negative Genetic
EUC1 YMR111C Sequence-specific DNA binding protein genetic 1 1 1 Negative Genetic
PDS5 YMR076C Cohesion maintenance factor genetic 1 1 1 Negative Genetic
KIP1 YBL063W Kinesin-related motor protein genetic 1 1 1 Negative Genetic
SEC39 YLR440C Component of the Dsl1p tethering complex genetic 1 1 1 Negative Genetic
EMC6 YLL014W Member of conserved ER transmembrane complex genetic 1 1 1 Positive Genetic
AUS1 YOR011W Plasma membrane sterol transporter of the ATP-binding cassette family genetic 1 1 1 Negative Genetic
COY1 YKL179C Golgi membrane protein with similarity to mammalian CASP genetic 1 1 1 Negative Genetic
SLK19 YOR195W Kinetochore-associated protein genetic 1 1 1 Negative Genetic
GTA1 YEL043W Protein of unknown function genetic 1 1 1 Negative Genetic
PBN1 YCL052C Component of glycosylphosphatidylinositol-mannosyltransferase I genetic 1 1 1 Negative Genetic
HSP26 YBR072W Small heat shock protein (sHSP) with chaperone activity genetic 1 1 1 Phenotypic Enhancement
EMP70 YLR083C Protein with a role in cellular adhesion and filamentous growth genetic 1 1 1 Negative Genetic
UBP8 YMR223W Ubiquitin-specific protease component of the SAGA acetylation complex genetic 1 1 1 Positive Genetic
STH1 YIL126W ATPase component of the RSC chromatin remodeling complex genetic 1 1 1 Synthetic Growth Defect
MSC2 YDR205W Endoplasmic reticulum zinc transporter genetic 1 1 1 Negative Genetic
VMA21 YGR105W Integral membrane protein required for V-ATPase function genetic 1 1 1 Synthetic Growth Defect
PAM17 YKR065C Constituent of the TIM23 complex genetic 1 1 1 Negative Genetic
RIO1 YOR119C Serine kinase involved in cell cycle regulation and rDNA integrity genetic 1 1 1 Negative Genetic
YPL150W YPL150W Protein kinase of unknown cellular role physical 1 1 1 Biochemical Activity
YEH1 YLL012W Steryl ester hydrolase physical 1 1 1 Affinity Capture-MS
YKR104W YKR104W Putative transporter of the MRP subfamily genetic 1 1 1 Negative Genetic
YMC2 YBR104W Putative mitochondrial inner membrane transporter genetic 1 1 1 Negative Genetic
YSA1 YBR111C Nudix hydrolase family member with ADP-ribose pyrophosphatase activity genetic 1 1 1 Negative Genetic
YDL157C YDL157C Putative protein of unknown function genetic 1 1 1 Positive Genetic
YEA4 YEL004W Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter genetic 1 1 1 Positive Genetic
YUR1 YJL139C Mannosyltransferase involved in protein N-glycosylation genetic 1 1 1 Positive Genetic
YJU3 YKL094W Monoglyceride lipase (MGL) that hydrolyzes fatty acid ethyl esters genetic 1 1 1 Negative Genetic
YPT7 YML001W Rab family GTPase genetic 1 1 1 Positive Genetic
YMD8 YML038C Putative nucleotide sugar transporter genetic 1 1 1 Positive Genetic
YOR1 YGR281W Plasma membrane ATP-binding cassette (ABC) transporter genetic 1 1 1 Negative Genetic
YHC1 YLR298C Component of the U1 snRNP complex required for pre-mRNA splicing genetic 1 1 1 Positive Genetic
YGR122W YGR122W Protein that may be involved in pH regulation genetic 1 1 1 Positive Genetic
YRA1 YDR381W Nuclear polyadenylated RNA-binding protein genetic 1 1 1 Negative Genetic
YPT1 YFL038C Rab family GTPase genetic 1 1 1 Negative Genetic
YPP1 YGR198W Cargo-transport protein involved in endocytosis genetic 1 1 1 Negative Genetic
ZPR1 YGR211W Essential protein with two zinc fingers genetic 1 1 1 Negative Genetic
YKT6 YKL196C Vesicle membrane protein (v-SNARE) with acyltransferase activity genetic 1 1 1 Negative Genetic
YER079W YER079W Putative protein of unknown function genetic 1 1 1 Negative Genetic
YER134C YER134C Magnesium-dependent acid phosphatase genetic 1 1 1 Negative Genetic
YGL159W YGL159W Putative protein of unknown function genetic 1 1 1 Negative Genetic
YVH1 YIR026C Dual specificity protein phosphatase genetic 1 1 1 Negative Genetic
YSR3 YKR053C Dihydrosphingosine 1-phosphate phosphatase genetic 1 1 1 Negative Genetic
YLR297W YLR297W Protein of unknown function genetic 1 1 1 Negative Genetic
YLR363W-A YLR363W-A Protein of unknown function genetic 1 1 1 Negative Genetic
YMR321C YMR321C Putative protein of unknown function genetic 1 1 1 Negative Genetic
YHR138C YHR138C Protein of unknown function genetic 1 1 1 Negative Genetic
YRA2 YKL214C Member of the REF (RNA and export factor binding proteins) family genetic 1 1 1 Negative Genetic
YOL057W YOL057W Dipeptidyl-peptidase III genetic 1 1 1 Negative Genetic
YRM1 YOR172W Zinc finger transcription factor involved in multidrug resistance genetic 1 1 1 Negative Genetic
YPL068C YPL068C Protein of unknown function genetic 1 1 1 Negative Genetic
YPL225W YPL225W Protein of unknown function genetic 1 1 1 Negative Genetic
YPR172W YPR172W Protein of unknown function genetic 1 1 1 Negative Genetic
YNG2 YHR090C Subunit of NuA4, an essential histone acetyltransferase complex genetic 1 1 1 Negative Genetic
GAS5 YOL030W 1,3-beta-glucanosyltransferase genetic 1 1 1 Negative Genetic
VRG4 YGL225W Golgi GDP-mannose transporter genetic 1 1 1 Negative Genetic
ERG7 YHR072W Lanosterol synthase genetic 1 1 1 Negative Genetic
TIP1 YBR067C Major cell wall mannoprotein with possible lipase activity genetic 1 1 1 Positive Genetic
ALG3 YBL082C Dolichol-P-Man dependent alpha(1-3) mannosyltransferase genetic 1 1 1 Positive Genetic
NFS1 YCL017C Cysteine desulfurase involved in iron-sulfur cluster biogenesis genetic 1 1 1 Positive Genetic
HRQ1 YDR291W 3'-5' DNA helicase of the conserved RecQ family genetic 1 1 1 Positive Genetic
PUF4 YGL014W Member of the PUF protein family physical 1 1 1 Affinity Capture-RNA
ICL1 YER065C Isocitrate lyase genetic 1 1 1 Positive Genetic
TFC6 YDR362C Subunit of RNA polymerase III transcription initiation factor complex physical 1 1 1 Affinity Capture-MS
TFC6 YDR362C Subunit of RNA polymerase III transcription initiation factor complex genetic 1 1 1 Negative Genetic
TSA1 YML028W Thioredoxin peroxidase genetic 1 1 1 Synthetic Lethality
STP1 YDR463W Transcription factor genetic 1 1 1 Negative Genetic
BRL1 YHR036W Essential nuclear envelope/ER integral membrane protein genetic 1 1 1 Negative Genetic
LCB5 YLR260W Minor sphingoid long-chain base kinase genetic 1 1 1 Negative Genetic
VID24 YBR105C GID Complex regulatory subunit physical 1 1 1 Affinity Capture-MS
IPF1 YDL176W Protein of unknown function involved in actin patch formation genetic 1 1 1 Negative Genetic
PSD2 YGR170W Phosphatidylserine decarboxylase of the Golgi and vacuolar membranes genetic 1 1 1 Negative Genetic
ORC4 YPR162C Subunit of the origin recognition complex (ORC) genetic 1 1 1 Negative Genetic
INA22 YIR024C F1F0 ATP synthase peripheral stalk assembly factor genetic 1 1 1 Negative Genetic
RTC3 YHR087W Protein of unknown function involved in RNA metabolism genetic 1 1 1 Negative Genetic
FUN14 YAL008W Integral mitochondrial outer membrane (MOM) protein genetic 1 1 1 Negative Genetic
GCD14 YJL125C Subunit of tRNA (1-methyladenosine) methyltransferase genetic 1 1 1 Negative Genetic
CTP1 YBR291C Mitochondrial inner membrane citrate transporter genetic 1 1 1 Positive Genetic
RPP1A YDL081C Ribosomal stalk protein P1 alpha genetic 1 1 1 Negative Genetic
URB2 YJR041C Protein required for normal metabolism of the rRNA primary transcript genetic 1 1 1 Negative Genetic
SBA1 YKL117W Co-chaperone that binds and regulates Hsp90 family chaperones genetic 1 1 1 Negative Genetic
ELF1 YKL160W Transcription elongation factor with a conserved zinc finger domain genetic 1 1 1 Positive Genetic
SSE2 YBR169C Member of Hsp110 subclass of the heat shock protein 70 (HSP70) family physical 1 1 1 Affinity Capture-Western
RTT109 YLL002W Histone acetyltransferase genetic 1 1 1 Synthetic Growth Defect
SLX4 YLR135W Endonuclease involved in processing DNA genetic 1 1 1 Negative Genetic
UGO1 YDR470C Outer membrane component of the mitochondrial fusion machinery genetic 1 1 1 Negative Genetic
ROT1 YMR200W Molecular chaperone involved in protein folding in ER genetic 1 1 1 Positive Genetic
FLO11 YIR019C GPI-anchored cell surface glycoprotein (flocculin) genetic 1 1 1 Phenotypic Suppression
FMP41 YNL168C Putative protein of unknown function genetic 1 1 1 Negative Genetic
GIS2 YNL255C Translational activator for mRNAs with internal ribosome entry sites physical 1 1 1 Affinity Capture-RNA
SGT2 YOR007C Glutamine-rich cytoplasmic cochaperone physical 1 1 1 Affinity Capture-Western
TMA46 YOR091W Protein of unknown function that associates with translating ribosomes physical 1 1 1 Affinity Capture-MS
LEU9 YOR108W Alpha-isopropylmalate synthase II (2-isopropylmalate synthase) genetic 1 1 1 Negative Genetic
ALD4 YOR374W Mitochondrial aldehyde dehydrogenase genetic 1 1 1 Positive Genetic
RPS6A YPL090C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
GYP7 YDL234C GTPase-activating protein for yeast Rab family members genetic 1 1 1 Negative Genetic
MUB1 YMR100W MYND domain-containing protein genetic 1 1 1 Positive Genetic
LDB19 YOR322C Alpha-arrestin, Ub-ligase adaptor for Rsp5p genetic 1 1 1 Positive Genetic
RPS9A YPL081W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
TUB3 YML124C Alpha-tubulin genetic 1 1 1 Negative Genetic
TUB2 YFL037W Beta-tubulin genetic 1 1 1 Positive Genetic
ERP3 YDL018C Protein with similarity to Emp24p and Erv25p genetic 1 1 1 Negative Genetic
SEH1 YGL100W Subunit of the Nup84 nuclear pore and SEACAT subcomplexes genetic 1 1 1 Positive Genetic
RPL4B YDR012W Ribosomal 60S subunit protein L4B genetic 1 1 1 Negative Genetic
SPB4 YFL002C Putative ATP-dependent RNA helicase physical 1 1 1 Affinity Capture-MS
SPB4 YFL002C Putative ATP-dependent RNA helicase genetic 1 1 1 Positive Genetic
PRI2 YKL045W Subunit of DNA primase genetic 1 1 1 Negative Genetic
URA2 YJL130C Bifunctional carbamoylphosphate synthetase/aspartate transcarbamylase physical 1 1 1 Affinity Capture-MS
RPS10A YOR293W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
ERP5 YHR110W Protein with similarity to Emp24p and Erv25p genetic 1 1 1 Positive Genetic
DPH5 YLR172C Methyltransferase required for synthesis of diphthamide genetic 1 1 1 Negative Genetic
OCA5 YHL029C Cytoplasmic protein required for replication of Brome mosaic virus genetic 1 1 1 Negative Genetic
ISR1 YPR106W Predicted protein kinase physical 1 1 1 Reconstituted Complex
GCS1 YDL226C ADP-ribosylation factor GTPase activating protein (ARF GAP) genetic 1 1 1 Positive Genetic
RPL26A YLR344W Ribosomal 60S subunit protein L26A physical 1 1 1 Affinity Capture-MS
RPS12 YOR369C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS19A YOL121C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
APJ1 YNL077W Hsp40 chaperone with a role in SUMO-mediated protein degradation physical 1 1 1 Affinity Capture-MS
APJ1 YNL077W Hsp40 chaperone with a role in SUMO-mediated protein degradation genetic 1 1 1 Dosage Rescue
CAB1 YDR531W Pantothenate kinase, ATP:D-pantothenate 4'-phosphotransferase genetic 1 1 1 Positive Genetic
DEG1 YFL001W tRNA:pseudouridine synthase genetic 1 1 1 Negative Genetic
CYC3 YAL039C Cytochrome c heme lyase (holocytochrome c synthase) genetic 1 1 1 Negative Genetic
DGA1 YOR245C Diacylglycerol acyltransferase genetic 1 1 1 Positive Genetic
EUG1 YDR518W Protein disulfide isomerase of the endoplasmic reticulum lumen genetic 1 1 1 Negative Genetic
GUP1 YGL084C Plasma membrane protein involved in remodeling GPI anchors genetic 1 1 1 Negative Genetic
COQ8 YGL119W ATPase required for ubiquinone biosynthesis and respiratory growth physical 1 1 1 Affinity Capture-MS
COQ8 YGL119W ATPase required for ubiquinone biosynthesis and respiratory growth genetic 1 1 1 Negative Genetic
PUF2 YPR042C PUF family mRNA-binding protein physical 1 1 1 Affinity Capture-RNA
SMY1 YKL079W Kinesin-like myosin passenger-protein genetic 1 1 1 Negative Genetic
NEJ1 YLR265C DNA end-binding protein required for nonhomologous end joining (NHEJ) genetic 1 1 1 Negative Genetic
SUB1 YMR039C Transcriptional regulator genetic 1 1 1 Positive Genetic
RCI37 YIL077C Protein that associates with the large mitoribosomal subunit genetic 1 1 1 Negative Genetic
TYE7 YOR344C Serine-rich protein that contains a bHLH DNA binding motif genetic 1 1 1 Negative Genetic
SET4 YJL105W Chromatin-associated protein involved in control of stress response physical 1 1 1 Affinity Capture-MS
CWH43 YCR017C GPI lipid remodelase genetic 1 1 1 Negative Genetic
DER1 YBR201W ER membrane protein that promotes export of misfolded polypeptides genetic 1 1 1 Positive Genetic
RPS27A YKL156W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RKI1 YOR095C Ribose-5-phosphate ketol-isomerase genetic 1 1 1 Negative Genetic
GSC2 YGR032W Catalytic subunit of 1,3-beta-glucan synthase genetic 1 1 1 Negative Genetic
TOM70 YNL121C Component of the TOM (translocase of outer membrane) complex physical 1 1 1 Reconstituted Complex
LIP1 YMR298W Ceramide synthase subunit genetic 1 1 1 Positive Genetic
DCR2 YLR361C Protein phosphatase genetic 1 1 1 Positive Genetic
JJJ3 YJR097W Iron-binding protein genetic 1 1 1 Dosage Rescue
CYC2 YOR037W Mitochondrial peripheral inner membrane protein genetic 1 1 1 Negative Genetic
RBA50 YDR527W Protein involved in transcription genetic 1 1 1 Negative Genetic
TUS1 YLR425W Guanine nucleotide exchange factor (GEF) that modulates Rho1p activity genetic 1 1 1 Positive Genetic
RIP1 YEL024W Ubiquinol-cytochrome-c reductase genetic 1 1 1 Negative Genetic
ERG4 YGL012W C-24(28) sterol reductase physical 1 1 1 Affinity Capture-MS
SAD1 YFR005C Conserved zinc-finger domain protein involved in pre-mRNA splicing genetic 1 1 1 Negative Genetic
AIM34 YMR003W Protein of unknown function genetic 1 1 1 Negative Genetic
TCB3 YML072C Cortical ER protein involved in ER-plasma membrane tethering genetic 1 1 1 Negative Genetic
SFT2 YBL102W Tetra-spanning membrane protein found mostly in the late Golgi genetic 1 1 1 Negative Genetic
LGE1 YPL055C Protein involved in histone H2B ubiquitination genetic 1 1 1 Positive Genetic
COS7 YDL248W Endosomal protein involved in turnover of plasma membrane proteins genetic 1 1 1 Negative Genetic
DYN3 YMR299C Dynein light intermediate chain (LIC) genetic 1 1 1 Negative Genetic
VOA1 YGR106C ER protein that functions in assembly of the V0 sector of V-ATPase genetic 1 1 1 Synthetic Growth Defect
SFB3 YHR098C Component of the Sec23p-Sfb3p heterodimer of the COPII vesicle coat genetic 1 1 1 Negative Genetic
COX23 YHR116W Protein that functions in mitochondrial copper homeostasis genetic 1 1 1 Negative Genetic
ERG29 YMR134W Protein of unknown function involved in ergosterol biosynthesis genetic 1 1 1 Negative Genetic
OAC1 YKL120W Mitochondrial inner membrane transporter genetic 1 1 1 Negative Genetic
ERG3 YLR056W C-5 sterol desaturase genetic 1 1 1 Positive Genetic
YDC1 YPL087W Alkaline dihydroceramidase, involved in sphingolipid metabolism genetic 1 1 1 Negative Genetic
VPS74 YDR372C Golgi PI4K effector, PtdIns4P sensor, and retention receptor genetic 1 1 1 Negative Genetic
TYR1 YBR166C Prephenate dehydrogenase involved in tyrosine biosynthesis genetic 1 1 1 Negative Genetic
ATG15 YCR068W Phospholipase genetic 1 1 1 Positive Genetic
MSN1 YOL116W Transcriptional activator genetic 1 1 1 Negative Genetic
BRR6 YGL247W Essential nuclear envelope integral membrane protein genetic 1 1 1 Negative Genetic
KTR7 YIL085C Putative mannosyltransferase involved in protein glycosylation genetic 1 1 1 Negative Genetic
PHS1 YJL097W Essential 3-hydroxyacyl-CoA dehydratase of the ER membrane genetic 1 1 1 Negative Genetic
URA5 YML106W Major orotate phosphoribosyltransferase (OPRTase) isozyme genetic 1 1 1 Negative Genetic
CUR1 YPR158W Sorting factor, central regulator of spatial protein quality control genetic 1 1 1 Dosage Growth Defect
EDC1 YGL222C RNA-binding protein that activates mRNA decapping directly genetic 1 1 1 Negative Genetic
AFB1 YLR040C MATalpha-specific a-factor blocker genetic 1 1 1 Negative Genetic
DIE2 YGR227W Dolichyl-phosphoglucose-dependent alpha-1,2-glucosyltransferase genetic 1 1 1 Positive Genetic
ELO1 YJL196C Elongase I, medium-chain acyl elongase genetic 1 1 1 Negative Genetic
COX9 YDL067C Subunit VIIa of cytochrome c oxidase (Complex IV) genetic 1 1 1 Negative Genetic
SAM50 YNL026W Component of the Sorting and Assembly Machinery (SAM) complex physical 1 1 1 Affinity Capture-MS
SLY41 YOR307C Protein involved in ER-to-Golgi transport genetic 1 1 1 Negative Genetic
STE24 YJR117W Highly conserved zinc metalloprotease genetic 1 1 1 Synthetic Growth Defect
IML2 YJL082W Protein required for clearance of inclusion bodies genetic 1 1 1 Positive Genetic
MTO1 YGL236C Mitochondrial protein genetic 1 1 1 Negative Genetic
MET5 YJR137C Sulfite reductase beta subunit genetic 1 1 1 Negative Genetic
CRS5 YOR031W Copper-binding metallothionein genetic 1 1 1 Negative Genetic
SAM37 YMR060C Component of the Sorting and Assembly Machinery (SAM) complex genetic 1 1 1 Negative Genetic
JAC1 YGL018C Specialized J-protein that functions in Fe-S cluster biogenesis genetic 1 1 1 Negative Genetic
TAH18 YPR048W Conserved NAPDH-dependent diflavin reductase genetic 1 1 1 Negative Genetic
FMC1 YIL098C Mitochondrial matrix protein genetic 1 1 1 Negative Genetic
GPI10 YGL142C Integral membrane protein involved in GPI anchor synthesis genetic 1 1 1 Negative Genetic
MSC1 YML128C Protein of unknown function genetic 1 1 1 Positive Genetic
DSC2 YOL073C Multi-transmembrane subunit of the DSC ubiquitin ligase complex genetic 1 1 1 Negative Genetic
IRC20 YLR247C E3 ubiquitin ligase and putative helicase physical 1 1 1 Affinity Capture-MS
MCT1 YOR221C Predicted malonyl-CoA:ACP transferase genetic 1 1 1 Negative Genetic
EMC3 YKL207W Member of conserved ER transmembrane complex genetic 1 1 1 Positive Genetic
DIT2 YDR402C N-formyltyrosine oxidase genetic 1 1 1 Negative Genetic
HEM25 YDL119C Mitochondrial glycine transporter genetic 1 1 1 Positive Genetic
CTR86 YCR054C Essential protein of unknown function genetic 1 1 1 Negative Genetic
DFR1 YOR236W Dihydrofolate reductase involved in tetrahydrofolate biosynthesis genetic 1 1 1 Negative Genetic
STE14 YDR410C Farnesyl cysteine-carboxyl methyltransferase genetic 1 1 1 Synthetic Rescue
VPS8 YAL002W Membrane-binding component of the CORVET complex genetic 1 1 1 Positive Genetic
GAS2 YLR343W 1,3-beta-glucanosyltransferase physical 1 1 1 Affinity Capture-MS
ROT2 YBR229C Glucosidase II catalytic subunit genetic 1 1 1 Positive Genetic
SUR2 YDR297W Sphinganine C4-hydroxylase genetic 1 1 1 Negative Genetic
SPT14 YPL175W UDP-glycosyltransferase subunit of the GPI-GnT complex genetic 1 1 1 Negative Genetic
PER1 YCR044C Protein of the endoplasmic reticulum genetic 1 1 1 Positive Genetic
HXT8 YJL214W Protein of unknown function with similarity to hexose transporters genetic 1 1 1 Negative Genetic
ALG8 YOR067C Glucosyl transferase genetic 1 1 1 Positive Genetic
TAX4 YJL083W EH domain-containing protein genetic 1 1 1 Negative Genetic
RPS15 YOL040C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
NCA2 YPR155C Protein that regulates expression of Fo-F1 ATP synthase subunits genetic 1 1 1 Negative Genetic
AIM36 YMR157C Protein of unknown function genetic 1 1 1 Negative Genetic
RCF1 YML030W Cytochrome c oxidase subunit genetic 1 1 1 Negative Genetic
SDH8 YBR269C Protein required for assembly of succinate dehydrogenase genetic 1 1 1 Positive Genetic
NNR1 YNL200C NADHX epimerase genetic 1 1 1 Negative Genetic
RTC2 YBR147W Putative vacuolar membrane transporter for cationic amino acids genetic 1 1 1 Negative Genetic
SER2 YGR208W Phosphoserine phosphatase of the phosphoglycerate pathway genetic 1 1 1 Negative Genetic
SEI1 YLR404W Seipin involved in lipid droplet (LD) assembly physical 1 1 1 Affinity Capture-MS
SEI1 YLR404W Seipin involved in lipid droplet (LD) assembly genetic 1 1 1 Negative Genetic
SOM1 YEL059C-A Subunit of the mitochondrial inner membrane peptidase (IMP) genetic 1 1 1 Negative Genetic
AIF1 YNR074C Mitochondrial cell death effector genetic 1 1 1 Negative Genetic
MRX20 YFR045W Putative mitochondrial transport protein genetic 1 1 1 Negative Genetic
TOP3 YLR234W DNA Topoisomerase III genetic 1 1 1 Negative Genetic
UCC1 YLR224W F-box protein and component of SCF ubiquitin ligase complexes genetic 1 1 1 Negative Genetic
SMP1 YBR182C MADS-box transcription factor involved in osmotic stress response genetic 1 1 1 Negative Genetic
SOL3 YHR163W 6-phosphogluconolactonase genetic 1 1 1 Negative Genetic
VMS1 YDR049W Peptidyl-tRNA hydrolase that releases stalled peptides from ribosomes, genetic 1 1 1 Negative Genetic
UPF3 YGR072W Component of the nonsense-mediated mRNA decay (NMD) pathway genetic 1 1 1 Negative Genetic
TSC10 YBR265W 3-ketosphinganine reductase genetic 1 1 1 Positive Genetic
TAH1 YCR060W Component of conserved R2TP complex (Rvb1-Rvb2-Tah1-Pih1) genetic 1 1 1 Negative Genetic
SPF1 YEL031W P-type ATPase, ion transporter of the ER membrane genetic 1 1 1 Negative Genetic
IRS4 YKR019C EH domain-containing protein genetic 1 1 1 Positive Genetic
KRE5 YOR336W Protein required for beta-1,6 glucan biosynthesis genetic 1 1 1 Positive Genetic
RIM9 YMR063W Plasma membrane protein of unknown function genetic 1 1 1 Positive Genetic
RKM3 YBR030W Ribosomal lysine methyltransferase genetic 1 1 1 Negative Genetic
PUS5 YLR165C Pseudouridine synthase genetic 1 1 1 Negative Genetic
YCS4 YLR272C Subunit of the condensin complex genetic 1 1 1 Synthetic Lethality
WAR1 YML076C Homodimeric Zn2Cys6 zinc finger transcription factor genetic 1 1 1 Negative Genetic
TRM12 YML005W S-adenosylmethionine-dependent methyltransferase genetic 1 1 1 Negative Genetic
YCK3 YER123W Palmitoylated vacuolar membrane-localized casein kinase I isoform genetic 1 1 1 Negative Genetic
VPS68 YOL129W Vacuolar membrane protein of unknown function genetic 1 1 1 Negative Genetic
SPR2 YOR214C Putative spore wall protein genetic 1 1 1 Negative Genetic
YAR066W YAR066W Putative GPI protein genetic 1 1 1 Negative Genetic