Standard name Systematic name Name description Description
ISR1 YPR106W Predicted protein kinase Predicted protein kinase; negatively regulates the hexosamine biosynthetic pathway (HBP), which converts fructose-6-phosphate into UDP-N-acetylglucosamine, a precursor of chitin biosynthesis, GPI-anchor formation and glycosylation; interacts genetically with GFA1, encoding the first enzyme in the HBP; involved in Gfa1p phosphorylation (S332, T334); contains a Pho85p-regulated SCF-CDC4 phosphodegron; unstable, cell cycle regulated protein, peaking at G1/S
Visualize the interactome of ISR1
Links to external databases:
SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)
M 175

CYCLoPs localization & abundance

WT1 WT2 WT3
no data no data no data

GFP localization & abundance

GFP localization GFP abundance
no data 521

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
ISR1 9 0 0 0 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
GFA1 YKL104C Glutamine-fructose-6-phosphate amidotransferase genetic 4 4 1 Dosage Lethality, Dosage Rescue, Synthetic Rescue, Synthetic Lethality
FKH1 YIL131C Forkhead family transcription factor regulation 3 2 3 chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation-chip evidence, ChEC-Seq experiments
PRR1 YKL116C Serine/threonine protein kinase genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
SSU72 YNL222W Phosphatase and transcription/RNA-processing factor genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
PKC1 YBL105C Protein serine/threonine kinase genetic 2 2 2 Synthetic Lethality, Negative Genetic
CHS2 YBR038W Chitin synthase II physical 2 2 2 Two-hybrid, Affinity Capture-MS
CLP1 YOR250C Component of the cleavage and polyadenylation factor I (CF I) genetic 2 1 2 Negative Genetic, Negative Genetic
CSG2 YBR036C Endoplasmic reticulum membrane protein genetic 2 1 2 Negative Genetic, Negative Genetic
PCF11 YDR228C mRNA 3' end processing factor genetic 2 1 2 Negative Genetic, Negative Genetic
RTT103 YDR289C Protein involved in transcription termination by RNA polymerase II genetic 2 1 2 Negative Genetic, Negative Genetic
RNA15 YGL044C Component of the cleavage and polyadenylation factor I (CF I) genetic 2 1 2 Negative Genetic, Negative Genetic
MPE1 YKL059C Subunit of CPF cleavage and polyadenylation factor and E3 Ub-ligase genetic 2 1 2 Negative Genetic, Negative Genetic
RPL8B YLL045C Ribosomal 60S subunit protein L8A genetic 2 1 2 Negative Genetic, Negative Genetic
ORM2 YLR350W Protein that mediates sphingolipid homeostasis genetic 2 1 2 Negative Genetic, Negative Genetic
MEX67 YPL169C Poly(A)RNA binding protein involved in nuclear mRNA export genetic 2 1 2 Negative Genetic, Negative Genetic
SGF29 YCL010C Component of the HAT/Core module of the SAGA, SLIK, and ADA complexes genetic 2 1 2 Negative Genetic, Negative Genetic
SAC1 YKL212W Phosphatidylinositol phosphate phosphatase genetic 2 1 2 Negative Genetic, Negative Genetic
RKM1 YPL208W SET-domain lysine-N-methyltransferase genetic 2 1 2 Negative Genetic, Negative Genetic
APQ12 YIL040W Nuclear envelope/ER integral membrane protein genetic 2 1 2 Negative Genetic, Negative Genetic
RNA14 YMR061W Component of the cleavage and polyadenylation factor I (CF I) genetic 2 2 1 Synthetic Growth Defect, Synthetic Lethality
SFP1 YLR403W Regulates transcription of ribosomal protein and biogenesis genes regulation 1 1 1 DNA to cDNA expression microarray evidence
FKH2 YNL068C Forkhead family transcription factor regulation 1 1 1 ChEC-Seq experiments
XBP1 YIL101C Transcriptional repressor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
STP1 YDR463W Transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
TFC7 YOR110W RNA pol III transcription initiation factor complex (TFIIIC) subunit regulation 1 1 1 chromatin immunoprecipitation-chip evidence
GFA1 YKL104C Glutamine-fructose-6-phosphate amidotransferase regulation 1 1 1 protein kinase assay evidence
IKI3 YLR384C Subunit of Elongator complex genetic 1 1 1 Negative Genetic
ESA1 YOR244W Catalytic subunit of the histone acetyltransferase complex (NuA4) genetic 1 1 1 Negative Genetic
EAF1 YDR359C Component of the NuA4 histone acetyltransferase complex genetic 1 1 1 Negative Genetic
BRE1 YDL074C E3 ubiquitin ligase genetic 1 1 1 Negative Genetic
CFT2 YLR115W Subunit of the mRNA cleavage and polyadenlylation factor (CPF) genetic 1 1 1 Negative Genetic
GIR2 YDR152W Highly-acidic RWD domain-containing cytoplasmic protein physical 1 1 1 PCA
ALA1 YOR335C Cytoplasmic and mitochondrial alanyl-tRNA synthetase physical 1 1 1 Reconstituted Complex
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
CDC11 YJR076C Component of the septin ring that is required for cytokinesis physical 1 1 1 Reconstituted Complex
CTK1 YKL139W Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I) genetic 1 1 1 Negative Genetic
DOA1 YKL213C WD-repeat protein involved in ubiquitin-mediated protein degradation genetic 1 1 1 Negative Genetic
FIP1 YJR093C Subunit of cleavage polyadenylation factor (CPF) genetic 1 1 1 Negative Genetic
FRS1 YLR060W Beta subunit of cytoplasmic phenylalanyl-tRNA synthetase physical 1 1 1 Reconstituted Complex
GDI1 YER136W GDP dissociation inhibitor genetic 1 1 1 Positive Genetic
HRP1 YOL123W Subunit of cleavage factor I physical 1 1 1 Affinity Capture-MS
GFA1 YKL104C Glutamine-fructose-6-phosphate amidotransferase physical 1 1 1 Affinity Capture-MS
GIN4 YDR507C Protein kinase involved in bud growth and assembly of the septin ring genetic 1 1 1 Dosage Growth Defect
IES5 YER092W Non-essential INO80 chromatin remodeling complex subunit genetic 1 1 1 Negative Genetic
GLN1 YPR035W Glutamine synthetase (GS) genetic 1 1 1 Dosage Lethality
HEK2 YBL032W RNA binding protein involved in asymmetric localization of ASH1 mRNA physical 1 1 1 Affinity Capture-RNA
CRZ1 YNL027W Transcription factor, activates transcription of stress response genes physical 1 1 1 Reconstituted Complex
ATP3 YBR039W Gamma subunit of the F1 sector of mitochondrial F1F0 ATP synthase physical 1 1 1 Affinity Capture-MS
HYP2 YEL034W Translation elongation factor eIF-5A genetic 1 1 1 Positive Genetic
GSF2 YML048W Endoplasmic reticulum (ER) localized integral membrane protein physical 1 1 1 Reconstituted Complex
DUN1 YDL101C Cell-cycle checkpoint S/T protein kinase genetic 1 1 1 Negative Genetic
CDC4 YFL009W F-box protein required for both the G1/S and G2/M phase transitions physical 1 1 1 Affinity Capture-Western
CTF13 YMR094W Subunit of the CBF3 complex genetic 1 1 1 Negative Genetic
GPG1 YGL121C Proposed gamma subunit of the heterotrimeric G protein genetic 1 1 1 Positive Genetic
BIR1 YJR089W Subunit of chromosomal passenger complex (CPC) genetic 1 1 1 Negative Genetic
ESS1 YJR017C Peptidylprolyl-cis/trans-isomerase (PPIase) genetic 1 1 1 Negative Genetic
CTK3 YML112W Gamma subunit of C-terminal domain kinase I genetic 1 1 1 Negative Genetic
DUO1 YGL061C Essential subunit of the Dam1 complex (aka DASH complex) genetic 1 1 1 Negative Genetic
BUD27 YFL023W Unconventional prefoldin protein involved in translation initiation physical 1 1 1 Reconstituted Complex
ARP1 YHR129C Actin-related protein of the dynactin complex genetic 1 1 1 Negative Genetic
EBS1 YDR206W Protein involved in translation inhibition and nonsense-mediated decay physical 1 1 1 Affinity Capture-MS
GNA1 YFL017C Glucosamine-6-phosphate acetyltransferase genetic 1 1 1 Dosage Lethality
AFT1 YGL071W Transcription factor involved in iron utilization and homeostasis genetic 1 1 1 Positive Genetic
CLG1 YGL215W Cyclin-like protein that interacts with Pho85p genetic 1 1 1 Negative Genetic
ELP3 YPL086C Subunit of Elongator complex genetic 1 1 1 Negative Genetic
CRP1 YHR146W Protein that binds to cruciform DNA structures genetic 1 1 1 Negative Genetic
BFR1 YOR198C Component of mRNP complexes associated with polyribosomes physical 1 1 1 Affinity Capture-MS
AUR1 YKL004W Phosphatidylinositol:ceramide phosphoinositol transferase genetic 1 1 1 Negative Genetic
HAC1 YFL031W Basic leucine zipper (bZIP) transcription factor (ATF/CREB1 homolog) genetic 1 1 1 Phenotypic Suppression
EAF7 YNL136W Subunit of the NuA4 histone acetyltransferase complex genetic 1 1 1 Negative Genetic
ERG2 YMR202W C-8 sterol isomerase genetic 1 1 1 Negative Genetic
HRQ1 YDR291W 3'-5' DNA helicase of the conserved RecQ family genetic 1 1 1 Negative Genetic
GSH1 YJL101C Gamma glutamylcysteine synthetase genetic 1 1 1 Negative Genetic
PHO85 YPL031C Cyclin-dependent kinase physical 1 1 1 Biochemical Activity
PCL1 YNL289W Cyclin, interacts with cyclin-dependent kinase Pho85p physical 1 1 1 Biochemical Activity
XRN1 YGL173C Evolutionarily-conserved 5'-3' exonuclease physical 1 1 1 Affinity Capture-MS
KRE33 YNL132W Acetyltransferase required for biogenesis of small ribosomal subunit physical 1 1 1 Affinity Capture-MS
NAB6 YML117W Putative RNA-binding protein physical 1 1 1 Affinity Capture-MS
PBP4 YDL053C Pbp1p binding protein physical 1 1 1 Affinity Capture-MS
TES1 YJR019C Peroxisomal acyl-CoA thioesterase physical 1 1 1 Affinity Capture-MS
TYS1 YGR185C Cytoplasmic tyrosyl-tRNA synthetase physical 1 1 1 Affinity Capture-MS
RGC1 YPR115W Putative regulator of the Fps1p glycerol channel physical 1 1 1 Affinity Capture-MS
LEU4 YNL104C Alpha-isopropylmalate synthase (2-isopropylmalate synthase) physical 1 1 1 Reconstituted Complex
QRI1 YDL103C UDP-N-acetylglucosamine pyrophosphorylase physical 1 1 1 Reconstituted Complex
QRI1 YDL103C UDP-N-acetylglucosamine pyrophosphorylase genetic 1 1 1 Dosage Lethality
RIM11 YMR139W Protein kinase physical 1 1 1 Reconstituted Complex
RIM4 YHL024W Putative RNA-binding protein physical 1 1 1 Reconstituted Complex
RNR4 YGR180C Ribonucleotide-diphosphate reductase (RNR) small subunit physical 1 1 1 Reconstituted Complex
STI1 YOR027W Evolutionarily-conserved Hsp90 cochaperone physical 1 1 1 Reconstituted Complex
TOM70 YNL121C Component of the TOM (translocase of outer membrane) complex physical 1 1 1 Reconstituted Complex
TRZ1 YKR079C tRNA 3'-end processing endonuclease tRNase Z physical 1 1 1 Reconstituted Complex
YDJ1 YNL064C Type I HSP40 co-chaperone physical 1 1 1 Reconstituted Complex
YGR210C YGR210C Putative protein of unknown function physical 1 1 1 Reconstituted Complex
YJR154W YJR154W Putative protein of unknown function physical 1 1 1 Reconstituted Complex
YKR018C YKR018C Protein of unknown function physical 1 1 1 Reconstituted Complex
YPL077C YPL077C Putative protein of unknown function physical 1 1 1 Reconstituted Complex
YPT7 YML001W Rab family GTPase physical 1 1 1 Reconstituted Complex
PAT1 YCR077C Deadenylation-dependent mRNA-decapping factor physical 1 1 1 Affinity Capture-RNA
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
REG1 YDR028C Regulatory subunit of type 1 protein phosphatase Glc7p genetic 1 1 1 Positive Genetic
MNN10 YDR245W Subunit of a Golgi mannosyltransferase complex genetic 1 1 1 Positive Genetic
SAP155 YFR040W Protein required for function of the Sit4p protein phosphatase genetic 1 1 1 Positive Genetic
OCA1 YNL099C Putative protein tyrosine phosphatase genetic 1 1 1 Positive Genetic
RVB1 YDR190C ATP-dependent DNA helicase, also known as pontin genetic 1 1 1 Negative Genetic
NIC96 YFR002W Linker nucleoporin component of the nuclear pore complex (NPC) genetic 1 1 1 Negative Genetic
SPC24 YMR117C Component of the kinetochore-associated Ndc80 complex genetic 1 1 1 Negative Genetic
KAR2 YJL034W ATPase involved in protein import into the ER genetic 1 1 1 Positive Genetic
URN1 YPR152C Protein of unknown function containing WW and FF domains genetic 1 1 1 Negative Genetic
MET32 YDR253C Zinc-finger DNA-binding transcription factor genetic 1 1 1 Positive Genetic
PPT1 YGR123C Protein serine/threonine phosphatase genetic 1 1 1 Positive Genetic
VPS71 YML041C Nucleosome-binding component of the SWR1 complex genetic 1 1 1 Negative Genetic
MET18 YIL128W Component of cytosolic iron-sulfur protein assembly (CIA) machinery genetic 1 1 1 Negative Genetic
PPH3 YDR075W Catalytic subunit of protein phosphatase PP4 complex genetic 1 1 1 Negative Genetic
PDB1 YBR221C E1 beta subunit of the pyruvate dehydrogenase (PDH) complex genetic 1 1 1 Dosage Growth Defect
PRM15 YMR278W Phosphoribomutase genetic 1 1 1 Dosage Growth Defect
TOA1 YOR194C TFIIA large subunit genetic 1 1 1 Dosage Growth Defect
MSA1 YOR066W Activator of G1-specific transcription factors MBF and SBF genetic 1 1 1 Dosage Growth Defect
SUR1 YPL057C Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit genetic 1 1 1 Negative Genetic
PMI40 YER003C Mannose-6-phosphate isomerase genetic 1 1 1 Positive Genetic
ORC2 YBR060C Subunit of the origin recognition complex (ORC) genetic 1 1 1 Negative Genetic
NSE4 YDL105W Component of the SMC5-SMC6 complex genetic 1 1 1 Negative Genetic
NSE3 YDR288W Component of the SMC5-SMC6 complex genetic 1 1 1 Negative Genetic
UTP4 YDR324C Subunit of U3-containing 90S preribosome and SSU processome complexes genetic 1 1 1 Negative Genetic
NTF2 YER009W Nuclear envelope protein genetic 1 1 1 Negative Genetic
SPC105 YGL093W Subunit of a kinetochore-microtubule binding complex genetic 1 1 1 Negative Genetic
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein genetic 1 1 1 Negative Genetic
KAP95 YLR347C Karyopherin beta genetic 1 1 1 Negative Genetic
NSE5 YML023C Component of the SMC5-SMC6 complex genetic 1 1 1 Negative Genetic
MRS6 YOR370C Rab escort protein genetic 1 1 1 Negative Genetic
SYN8 YAL014C Endosomal SNARE related to mammalian syntaxin 8 genetic 1 1 1 Negative Genetic
VBA4 YDR119W Protein of unknown function genetic 1 1 1 Negative Genetic
MZM1 YDR493W Protein required for assembly of the cytochrome bc(1) complex genetic 1 1 1 Negative Genetic
RPA49 YNL248C RNA polymerase I subunit A49 genetic 1 1 1 Negative Genetic
RPD3 YNL330C Histone deacetylase, component of both the Rpd3S and Rpd3L complexes genetic 1 1 1 Negative Genetic
YOR1 YGR281W Plasma membrane ATP-binding cassette (ABC) transporter genetic 1 1 1 Negative Genetic
LEA1 YPL213W Component of U2 snRNP complex genetic 1 1 1 Negative Genetic
RVS161 YCR009C Amphiphysin-like lipid raft protein genetic 1 1 1 Negative Genetic
NHP10 YDL002C Non-essential INO80 chromatin remodeling complex subunit genetic 1 1 1 Negative Genetic
TCP1 YDR212W Alpha subunit of chaperonin-containing T-complex genetic 1 1 1 Negative Genetic
TFB1 YDR311W Subunit of TFIIH and nucleotide excision repair factor 3 complexes genetic 1 1 1 Negative Genetic
RPN12 YFR052W Subunit of the 19S regulatory particle of the 26S proteasome lid genetic 1 1 1 Negative Genetic
VPS5 YOR069W Nexin-1 homolog genetic 1 1 1 Negative Genetic
SUP35 YDR172W Translation termination factor eRF3 genetic 1 1 1 Negative Genetic
PMT7 YDR307W Putative protein mannosyltransferase similar to Pmt1p genetic 1 1 1 Negative Genetic
UBP3 YER151C Ubiquitin-specific protease that cleaves Ub-protein fusions genetic 1 1 1 Positive Genetic
YJR011C YJR011C Putative protein of unknown function genetic 1 1 1 Negative Genetic
SPE2 YOL052C S-adenosylmethionine decarboxylase genetic 1 1 1 Negative Genetic
SFL1 YOR140W Transcriptional repressor and activator genetic 1 1 1 Positive Genetic
TGS1 YPL157W Trimethyl guanosine synthase, conserved nucleolar methyl transferase genetic 1 1 1 Negative Genetic
RTF1 YGL244W Subunit of RNAPII-associated chromatin remodeling Paf1 complex genetic 1 1 1 Negative Genetic
URM1 YIL008W Ubiquitin-like protein involved in thiolation of cytoplasmic tRNAs genetic 1 1 1 Negative Genetic
SRN2 YLR119W Component of the ESCRT-I complex genetic 1 1 1 Negative Genetic
TLG2 YOL018C Syntaxin-like t-SNARE genetic 1 1 1 Negative Genetic
NAB3 YPL190C RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p) genetic 1 1 1 Negative Genetic
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 1 1 1 Negative Genetic
PCM1 YEL058W Essential N-acetylglucosamine-phosphate mutase genetic 1 1 1 Dosage Lethality
AZR1 YGR224W Plasma membrane transporter of the major facilitator superfamily genetic 1 1 1 Positive Genetic
CAB1 YDR531W Pantothenate kinase, ATP:D-pantothenate 4'-phosphotransferase genetic 1 1 1 Negative Genetic
CEM1 YER061C Mitochondrial beta-keto-acyl synthase genetic 1 1 1 Negative Genetic
EDC1 YGL222C RNA-binding protein that activates mRNA decapping directly genetic 1 1 1 Positive Genetic
GTF1 YGR102C Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex genetic 1 1 1 Dosage Growth Defect