PHO85 |
YPL031C |
Cyclin-dependent kinase |
physical |
7 |
5 |
6 |
Affinity Capture-Western, Reconstituted Complex, Two-hybrid, Biochemical Activity, Affinity Capture-MS, Biochemical Activity, Reconstituted Complex |
BNI1 |
YNL271C |
Formin |
genetic |
4 |
4 |
4 |
Synthetic Lethality, Phenotypic Enhancement, Dosage Lethality, Synthetic Growth Defect |
FKH1 |
YIL131C |
Forkhead family transcription factor |
regulation |
4 |
3 |
4 |
chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation- exonuclease evidence, ChEC-Seq experiments |
SLT2 |
YHR030C |
Serine/threonine MAP kinase |
genetic |
4 |
3 |
4 |
Dosage Rescue, Synthetic Growth Defect, Dosage Growth Defect, Dosage Rescue |
NPA3 |
YJR072C |
Member of the conserved GPN-loop GTPase family |
physical |
4 |
4 |
1 |
Two-hybrid, Affinity Capture-Western, Reconstituted Complex, Biochemical Activity |
NCP1 |
YHR042W |
NADP-cytochrome P450 reductase |
physical |
4 |
4 |
1 |
Two-hybrid, Affinity Capture-Western, Reconstituted Complex, Biochemical Activity |
HMS1 |
YOR032C |
bHLH protein with similarity to myc-family transcription factors |
physical |
4 |
4 |
1 |
Two-hybrid, Affinity Capture-Western, Reconstituted Complex, Biochemical Activity |
FKH2 |
YNL068C |
Forkhead family transcription factor |
regulation |
3 |
3 |
3 |
chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation- exonuclease evidence, ChEC-Seq experiments |
BEM2 |
YER155C |
Rho GTPase activating protein (RhoGAP) |
genetic |
3 |
2 |
3 |
Phenotypic Enhancement, Synthetic Lethality, Synthetic Lethality |
DMA1 |
YHR115C |
Ubiquitin-protein ligase (E3) |
physical |
3 |
2 |
2 |
Biochemical Activity, Affinity Capture-Western, Biochemical Activity |
MSN2 |
YMR037C |
Stress-responsive transcriptional activator |
regulation |
2 |
2 |
2 |
chromatin immunoprecipitation-chip evidence, RNA-sequencing evidence |
SWI4 |
YER111C |
DNA binding component of the SBF complex (Swi4p-Swi6p) |
regulation |
2 |
2 |
2 |
chromatin immunoprecipitation-chip evidence, DNA to cDNA expression microarray evidence |
CDC42 |
YLR229C |
Small rho-like GTPase |
genetic |
2 |
2 |
2 |
Phenotypic Enhancement, Synthetic Lethality |
BCK1 |
YJL095W |
MAPKKK acting in the protein kinase C signaling pathway |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Dosage Rescue |
HAP5 |
YOR358W |
Subunit of the Hap2p/3p/4p/5p CCAAT-binding complex |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
NUT1 |
YGL151W |
Component of the RNA polymerase II mediator complex |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
DHH1 |
YDL160C |
Cytoplasmic DEAD-box helicase and mRNA decapping activator |
physical |
2 |
1 |
2 |
Affinity Capture-RNA, Affinity Capture-RNA |
MED1 |
YPR070W |
Subunit of the RNA polymerase II mediator complex |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
NST1 |
YNL091W |
Translational inhibitor and suppressor of proteasome-assembly defects |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
PCL2 |
YDL127W |
Cyclin, interacts with cyclin-dependent kinase Pho85p |
genetic |
2 |
1 |
2 |
Phenotypic Enhancement, Phenotypic Enhancement |
SWI6 |
YLR182W |
Transcription cofactor |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
SSO2 |
YMR183C |
Plasma membrane t-SNARE |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
SWS2 |
YNL081C |
Putative mitochondrial ribosomal protein of the small subunit |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
RGL1 |
YPL066W |
Regulator of Rho1p signaling, cofactor of Tus1p |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
QCR2 |
YPR191W |
Subunit 2 of ubiquinol cytochrome-c reductase (Complex III) |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
CYK3 |
YDL117W |
SH3-domain protein located in the bud neck and cytokinetic actin ring |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
CYT1 |
YOR065W |
Cytochrome c1 |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
CBT1 |
YKL208W |
Protein involved in 5' RNA end processing |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
MNE1 |
YOR350C |
Protein involved in splicing Group I aI5-beta intron from COX1 mRNA |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
SSA1 |
YAL005C |
ATPase involved in protein folding and NLS-directed nuclear transport |
physical |
2 |
2 |
1 |
Two-hybrid, Affinity Capture-Western |
SFP1 |
YLR403W |
Regulates transcription of ribosomal protein and biogenesis genes |
regulation |
1 |
1 |
1 |
DNA to cDNA expression microarray evidence |
TEC1 |
YBR083W |
Transcription factor targeting filamentation genes and Ty1 expression |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
AFT2 |
YPL202C |
Iron-regulated transcriptional activator |
regulation |
1 |
1 |
1 |
DNA to cDNA expression microarray evidence |
XBP1 |
YIL101C |
Transcriptional repressor |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
BUR6 |
YER159C |
Subunit of a heterodimeric NC2 transcription regulator complex |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
RAP1 |
YNL216W |
Essential DNA-binding transcription regulator that binds many loci |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
STP1 |
YDR463W |
Transcription factor |
regulation |
1 |
1 |
1 |
DNA to cDNA expression microarray evidence |
STB1 |
YNL309W |
Protein with role in regulation of MBF-specific transcription at Start |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
MSN4 |
YKL062W |
Stress-responsive transcriptional activator |
regulation |
1 |
1 |
1 |
RNA-sequencing evidence |
YRR1 |
YOR162C |
Zn2-Cys6 zinc-finger transcription factor |
regulation |
1 |
1 |
1 |
DNA to cDNA expression microarray evidence |
RSF2 |
YJR127C |
Zinc-finger protein |
regulation |
1 |
1 |
1 |
DNA to cDNA expression microarray evidence |
SKO1 |
YNL167C |
Basic leucine zipper transcription factor of the ATF/CREB family |
regulation |
1 |
1 |
1 |
DNA to cDNA expression microarray evidence |
RPD3 |
YNL330C |
Histone deacetylase, component of both the Rpd3S and Rpd3L complexes |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
PHO2 |
YDL106C |
Homeobox transcription factor |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
ASH1 |
YKL185W |
Component of the Rpd3L histone deacetylase complex |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
SWI6 |
YLR182W |
Transcription cofactor |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
MBP1 |
YDL056W |
Transcription factor |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
MCM1 |
YMR043W |
Transcription factor |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
PUT3 |
YKL015W |
Transcriptional activator |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
TOD6 |
YBL054W |
PAC motif binding protein involved in rRNA and ribosome biogenesis |
regulation |
1 |
1 |
1 |
DNA to cDNA expression microarray evidence |
RDR1 |
YOR380W |
Transcriptional repressor involved in regulating multidrug resistance |
regulation |
1 |
1 |
1 |
DNA to cDNA expression microarray evidence |
AME1 |
YBR211C |
Essential kinetochore protein associated with microtubules and SPBs |
physical |
1 |
1 |
1 |
Biochemical Activity |
NPL3 |
YDR432W |
RNA-binding protein |
physical |
1 |
1 |
1 |
Biochemical Activity |
NPL3 |
YDR432W |
RNA-binding protein |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
BCP1 |
YDR361C |
Essential nuclear chaperone for ribosomal protein Rpl23p |
physical |
1 |
1 |
1 |
Biochemical Activity |
CCR4 |
YAL021C |
Component of the CCR4-NOT transcriptional complex |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
BEM1 |
YBR200W |
Protein containing SH3-domains |
genetic |
1 |
1 |
1 |
Negative Genetic |
CDC28 |
YBR160W |
Cyclin-dependent kinase (CDK) catalytic subunit |
genetic |
1 |
1 |
1 |
Dosage Lethality |
CDC12 |
YHR107C |
Component of the septin ring that is required for cytokinesis |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
GIN4 |
YDR507C |
Protein kinase involved in bud growth and assembly of the septin ring |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
KCC4 |
YCL024W |
Protein kinase of the bud neck involved in the septin checkpoint |
physical |
1 |
1 |
1 |
Biochemical Activity |
NGL2 |
YMR285C |
Protein involved in 5.8S rRNA processing |
genetic |
1 |
1 |
1 |
Negative Genetic |
HYP2 |
YEL034W |
Translation elongation factor eIF-5A |
genetic |
1 |
1 |
1 |
Dosage Rescue |
ELM1 |
YKL048C |
Serine/threonine protein kinase |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
CDC4 |
YFL009W |
F-box protein required for both the G1/S and G2/M phase transitions |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
KSP1 |
YHR082C |
Serine/threonine protein kinase |
physical |
1 |
1 |
1 |
Biochemical Activity |
FPK1 |
YNR047W |
Ser/Thr protein kinase |
physical |
1 |
1 |
1 |
Biochemical Activity |
ESS1 |
YJR017C |
Peptidylprolyl-cis/trans-isomerase (PPIase) |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
CLN3 |
YAL040C |
G1 cyclin involved in cell cycle progression |
genetic |
1 |
1 |
1 |
Dosage Rescue |
BNI4 |
YNL233W |
Targeting subunit for Glc7p protein phosphatase |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
BNI4 |
YNL233W |
Targeting subunit for Glc7p protein phosphatase |
genetic |
1 |
1 |
1 |
Dosage Lethality |
BAS1 |
YKR099W |
Myb-related transcription factor |
genetic |
1 |
1 |
1 |
Dosage Lethality |
ASK10 |
YGR097W |
Regulator of the Fps1p glycerol channel |
genetic |
1 |
1 |
1 |
Positive Genetic |
PHO4 |
YFR034C |
Basic helix-loop-helix (bHLH) transcription factor of the myc-family |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
ROM2 |
YLR371W |
Guanine nucleotide exchange factor (GEF) for Rho1p and Rho2p |
physical |
1 |
1 |
1 |
Biochemical Activity |
SHS1 |
YDL225W |
Component of the septin ring that is required for cytokinesis |
physical |
1 |
1 |
1 |
Biochemical Activity |
SFB3 |
YHR098C |
Component of the Sec23p-Sfb3p heterodimer of the COPII vesicle coat |
physical |
1 |
1 |
1 |
Biochemical Activity |
RVS167 |
YDR388W |
Calmodulin-binding actin-associated protein |
physical |
1 |
1 |
1 |
Biochemical Activity |
REG1 |
YDR028C |
Regulatory subunit of type 1 protein phosphatase Glc7p |
physical |
1 |
1 |
1 |
Biochemical Activity |
RPG1 |
YBR079C |
eIF3a subunit of the eukaryotic translation initiation factor 3 (eIF3) |
physical |
1 |
1 |
1 |
Biochemical Activity |
SAP185 |
YJL098W |
Protein that forms a complex with the Sit4p protein phosphatase |
physical |
1 |
1 |
1 |
Biochemical Activity |
SSD1 |
YDR293C |
Translational repressor |
physical |
1 |
1 |
1 |
Biochemical Activity |
UGP1 |
YKL035W |
UDP-glucose pyrophosphorylase (UGPase) |
physical |
1 |
1 |
1 |
Biochemical Activity |
SRO9 |
YCL037C |
Cytoplasmic RNA-binding protein |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
SSB2 |
YNL209W |
Cytoplasmic ATPase that is a ribosome-associated molecular chaperone |
physical |
1 |
1 |
1 |
Co-purification |
PUF2 |
YPR042C |
PUF family mRNA-binding protein |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
VTS1 |
YOR359W |
Flap-structured DNA-binding and RNA-binding protein |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
SWI4 |
YER111C |
DNA binding component of the SBF complex (Swi4p-Swi6p) |
genetic |
1 |
1 |
1 |
Dosage Rescue |
RAD53 |
YPL153C |
DNA damage response kinase |
genetic |
1 |
1 |
1 |
Dosage Rescue |
YKE4 |
YIL023C |
Zinc transporter |
genetic |
1 |
1 |
1 |
Dosage Rescue |
PHO5 |
YBR093C |
Repressible acid phosphatase |
genetic |
1 |
1 |
1 |
Dosage Lethality |
SAK1 |
YER129W |
Upstream serine/threonine kinase for the SNF1 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
WHI5 |
YOR083W |
Repressor of G1 transcription |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
RTS1 |
YOR014W |
B-type regulatory subunit of protein phosphatase 2A (PP2A) |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
PET122 |
YER153C |
Mitochondrial translational activator specific for the COX3 mRNA |
genetic |
1 |
1 |
1 |
Negative Genetic |
RPL24B |
YGR148C |
Ribosomal 60S subunit protein L24B |
genetic |
1 |
1 |
1 |
Negative Genetic |
RSC2 |
YLR357W |
Component of the RSC chromatin remodeling complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
VHS2 |
YIL135C |
Regulator of septin dynamics |
genetic |
1 |
1 |
1 |
Dosage Rescue |
TYE7 |
YOR344C |
Serine-rich protein that contains a bHLH DNA binding motif |
genetic |
1 |
1 |
1 |
Dosage Lethality |
RIM101 |
YHL027W |
Cys2His2 zinc-finger transcriptional repressor |
genetic |
1 |
1 |
1 |
Dosage Rescue |
MPT5 |
YGL178W |
mRNA-binding protein of the PUF family |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
GIC1 |
YHR061C |
Rho-family GTPase interacting protein and Cdc42p effector |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
GTS1 |
YGL181W |
Protein involved in Arf3p regulation and in transcription regulation |
physical |
1 |
1 |
1 |
Biochemical Activity |
CDC19 |
YAL038W |
Pyruvate kinase |
physical |
1 |
1 |
1 |
Biochemical Activity |
MNN11 |
YJL183W |
Subunit of a Golgi mannosyltransferase complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
BCS1 |
YDR375C |
Protein translocase and chaperone required for Complex III assembly |
genetic |
1 |
1 |
1 |
Negative Genetic |
PAN3 |
YKL025C |
Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex |
physical |
1 |
1 |
1 |
Biochemical Activity |
CCC1 |
YLR220W |
Vacuolar Fe2+/Mn2+ transporter |
genetic |
1 |
1 |
1 |
Dosage Rescue |
MRC1 |
YCL061C |
S-phase checkpoint protein required for DNA replication |
genetic |
1 |
1 |
1 |
Dosage Rescue |
PAM1 |
YDR251W |
Essential protein of unknown function |
physical |
1 |
1 |
1 |
Biochemical Activity |
ISR1 |
YPR106W |
Predicted protein kinase |
physical |
1 |
1 |
1 |
Biochemical Activity |
IGD1 |
YFR017C |
Cytoplasmic protein that inhibits Gdb1p glycogen debranching activity |
physical |
1 |
1 |
1 |
Biochemical Activity |
MLF3 |
YNL074C |
Serine-rich protein of unknown function |
genetic |
1 |
1 |
1 |
Dosage Rescue |
COX12 |
YLR038C |
Subunit VIb of cytochrome c oxidase |
genetic |
1 |
1 |
1 |
Negative Genetic |
LIP2 |
YLR239C |
Lipoyl ligase |
genetic |
1 |
1 |
1 |
Negative Genetic |