Standard name Systematic name Name description Description
CLN3 YAL040C G1 cyclin involved in cell cycle progression G1 cyclin involved in cell cycle progression; activates Cdc28p kinase to promote G1 to S phase transition; plays a role in regulating transcription of other G1 cyclins, CLN1 and CLN2; regulated by phosphorylation and proteolysis; acetyl-CoA induces CLN3 transcription in response to nutrient repletion to promote cell-cycle entry; cell cycle arrest phenotype of the cln1 cln2 cln3 triple null mutant is complemented by any of human cyclins CCNA2, CCNB1, CCNC, CCND1, or CCNE1
Visualize the interactome of CLN3
Links to external databases:
SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)
G1(P) 20

CYCLoPs localization & abundance

WT1 WT2 WT3
no data no data no data

GFP localization & abundance

GFP localization GFP abundance
no data no data

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
CLN3 0 9 0 0 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
WHI5 YOR083W Repressor of G1 transcription genetic 13 6 9 Synthetic Rescue, Positive Genetic, Phenotypic Suppression, Synthetic Rescue, Dosage Rescue, Synthetic Rescue, Synthetic Rescue, Dosage Growth Defect, Synthetic Rescue, Phenotypic Enhancement, Phenotypic Suppression, Phenotypic Suppression, Synthetic Rescue
BCK2 YER167W Serine/threonine-rich protein involved in PKC1 signaling pathway genetic 13 5 9 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Rescue, Phenotypic Suppression, Dosage Rescue, Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Lethality, Phenotypic Suppression
CLN2 YPL256C G1 cyclin involved in regulation of the cell cycle genetic 12 6 11 Dosage Rescue, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Phenotypic Enhancement, Phenotypic Suppression, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Phenotypic Enhancement
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit physical 11 4 10 Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Biochemical Activity, Biochemical Activity, Two-hybrid, Affinity Capture-MS, Biochemical Activity, Biochemical Activity, Affinity Capture-Western, Biochemical Activity
SWI4 YER111C DNA binding component of the SBF complex (Swi4p-Swi6p) genetic 10 4 9 Dosage Rescue, Synthetic Lethality, Negative Genetic, Synthetic Rescue, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Lethality
CLN1 YMR199W G1 cyclin involved in regulation of the cell cycle genetic 9 6 8 Dosage Rescue, Synthetic Lethality, Synthetic Lethality, Phenotypic Enhancement, Phenotypic Suppression, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Phenotypic Enhancement
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit genetic 7 5 6 Synthetic Rescue, Synthetic Rescue, Phenotypic Enhancement, Phenotypic Suppression, Phenotypic Suppression, Dosage Lethality, Dosage Rescue
WHI3 YNL197C RNA binding protein that modulates mRNA stability physical 4 3 4 Affinity Capture-Western, Protein-RNA, Affinity Capture-RNA, Affinity Capture-RNA
GET2 YER083C Subunit of the GET complex genetic 4 2 4 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic
BRE1 YDL074C E3 ubiquitin ligase genetic 4 3 3 Negative Genetic, Synthetic Growth Defect, Dosage Rescue, Synthetic Growth Defect
WHI3 YNL197C RNA binding protein that modulates mRNA stability genetic 3 3 3 Phenotypic Enhancement, Phenotypic Suppression, Synthetic Rescue
FUS3 YBL016W Mitogen-activated serine/threonine protein kinase involved in mating genetic 3 3 3 Phenotypic Suppression, Phenotypic Enhancement, Positive Genetic
SIN3 YOL004W Component of both the Rpd3S and Rpd3L histone deacetylase complexes genetic 3 3 3 Positive Genetic, Phenotypic Suppression, Synthetic Rescue
SCH9 YHR205W AGC family protein kinase genetic 3 3 3 Phenotypic Enhancement, Negative Genetic, Synthetic Growth Defect
CDC4 YFL009W F-box protein required for both the G1/S and G2/M phase transitions physical 3 2 3 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western
FAR1 YJL157C CDK inhibitor and nuclear anchor genetic 3 2 3 Dosage Rescue, Phenotypic Enhancement, Phenotypic Enhancement
SIT4 YDL047W Ceramide-activated, type 2A-related serine-threonine phosphatase genetic 3 2 3 Dosage Rescue, Synthetic Lethality, Synthetic Lethality
RTS1 YOR014W B-type regulatory subunit of protein phosphatase 2A (PP2A) genetic 3 2 3 Negative Genetic, Phenotypic Suppression, Negative Genetic
TOP1 YOL006C Topoisomerase I genetic 3 2 3 Negative Genetic, Synthetic Growth Defect, Negative Genetic
CLA4 YNL298W Cdc42p-activated signal transducing kinase genetic 3 2 3 Negative Genetic, Negative Genetic, Dosage Growth Defect
CIK1 YMR198W Kinesin-associated protein genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
UME6 YDR207C Rpd3L histone deacetylase complex subunit genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
LSM6 YDR378C Lsm (Like Sm) protein genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
MNN10 YDR245W Subunit of a Golgi mannosyltransferase complex genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
CTK1 YKL139W Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I) genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
BRE5 YNR051C Ubiquitin protease cofactor genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
BUB1 YGR188C Protein kinase involved in the cell cycle checkpoint into anaphase genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
POG1 YIL122W DNA-binding transcriptional activator genetic 3 3 2 Synthetic Rescue, Synthetic Growth Defect, Negative Genetic
POL32 YJR043C Third subunit of DNA polymerase delta genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
MAD3 YJL013C Subunit of spindle-assembly checkpoint complex physical 2 2 2 Two-hybrid, Affinity Capture-Western
SWI6 YLR182W Transcription cofactor genetic 2 2 2 Synthetic Rescue, Positive Genetic
SIC1 YLR079W Cyclin-dependent kinase inhibitor (CKI) genetic 2 2 2 Phenotypic Enhancement, Synthetic Rescue
SST2 YLR452C GTPase-activating protein for Gpa1p genetic 2 2 2 Synthetic Lethality, Negative Genetic
RAP1 YNL216W Essential DNA-binding transcription regulator that binds many loci genetic 2 2 2 Synthetic Rescue, Negative Genetic
GET1 YGL020C Subunit of the GET complex genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
RPA14 YDR156W RNA polymerase I subunit A14 genetic 2 2 2 Negative Genetic, Phenotypic Enhancement
STB1 YNL309W Protein with role in regulation of MBF-specific transcription at Start genetic 2 2 2 Synthetic Rescue, Synthetic Growth Defect
ROM2 YLR371W Guanine nucleotide exchange factor (GEF) for Rho1p and Rho2p genetic 2 2 2 Phenotypic Suppression, Positive Genetic
ULP2 YIL031W Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins genetic 2 2 2 Phenotypic Suppression, Dosage Rescue
ARP8 YOR141C Nuclear actin-related protein involved in chromatin remodeling genetic 2 1 2 Negative Genetic, Negative Genetic
FAR1 YJL157C CDK inhibitor and nuclear anchor physical 2 1 2 Affinity Capture-Western, Affinity Capture-Western
SEC22 YLR268W R-SNARE protein genetic 2 1 2 Negative Genetic, Negative Genetic
MNN11 YJL183W Subunit of a Golgi mannosyltransferase complex genetic 2 1 2 Negative Genetic, Negative Genetic
RAS2 YNL098C GTP-binding protein genetic 2 1 2 Negative Genetic, Negative Genetic
KAR3 YPR141C Minus-end-directed microtubule motor genetic 2 1 2 Negative Genetic, Negative Genetic
SAC3 YDR159W mRNA export factor genetic 2 1 2 Negative Genetic, Negative Genetic
SGF73 YGL066W Subunit of DUBm module of SAGA and SLIK genetic 2 1 2 Negative Genetic, Negative Genetic
IRA2 YOL081W GTPase-activating protein genetic 2 1 2 Negative Genetic, Negative Genetic
LGE1 YPL055C Protein involved in histone H2B ubiquitination genetic 2 1 2 Negative Genetic, Negative Genetic
CSM1 YCR086W Nucleolar protein that mediates homolog segregation during meiosis I genetic 2 1 2 Negative Genetic, Negative Genetic
SSN3 YPL042C Component of the RNA polymerase II mediator complex genetic 2 1 2 Positive Genetic, Positive Genetic
STE50 YCL032W Adaptor protein for various signaling pathways genetic 2 1 2 Positive Genetic, Positive Genetic
GIM4 YEL003W Subunit of the heterohexameric cochaperone prefoldin complex genetic 2 1 2 Positive Genetic, Positive Genetic
CTK2 YJL006C Beta subunit of C-terminal domain kinase I (CTDK-I) genetic 2 1 2 Negative Genetic, Negative Genetic
RPD3 YNL330C Histone deacetylase, component of both the Rpd3S and Rpd3L complexes genetic 2 1 2 Synthetic Rescue, Synthetic Rescue
POL12 YBL035C B subunit of DNA polymerase alpha-primase complex genetic 2 1 2 Negative Genetic, Negative Genetic
DAN4 YJR151C Cell wall mannoprotein genetic 2 1 2 Negative Genetic, Negative Genetic
PRI2 YKL045W Subunit of DNA primase genetic 2 1 2 Negative Genetic, Negative Genetic
MOT3 YMR070W Transcriptional repressor, activator genetic 2 1 2 Negative Genetic, Negative Genetic
RFC5 YBR087W Subunit of heteropentameric Replication factor C (RF-C) genetic 2 1 2 Negative Genetic, Negative Genetic
SGT1 YOR057W Cochaperone protein genetic 2 1 2 Negative Genetic, Negative Genetic
UFE1 YOR075W t-SNARE protein required for retrograde vesicular traffic genetic 2 1 2 Negative Genetic, Negative Genetic
AKR1 YDR264C Palmitoyl transferase involved in protein palmitoylation genetic 2 1 2 Negative Genetic, Negative Genetic
RAD6 YGL058W Ubiquitin-conjugating enzyme (E2) genetic 2 2 1 Dosage Rescue, Synthetic Growth Defect
SET1 YHR119W Histone methyltransferase, subunit of the COMPASS (Set1C) complex genetic 2 2 1 Dosage Rescue, Synthetic Growth Defect
SRL3 YKR091W Repressor of transcription at Start genetic 2 2 1 Phenotypic Suppression, Dosage Lethality
TGL5 YOR081C Bifunctional triacylglycerol lipase and LPA acyltransferase genetic 2 1 1 Negative Genetic, Negative Genetic
SFP1 YLR403W Regulates transcription of ribosomal protein and biogenesis genes regulation 1 1 1 DNA to cDNA expression microarray evidence
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
FKH2 YNL068C Forkhead family transcription factor regulation 1 1 1 ChEC-Seq experiments
MET32 YDR253C Zinc-finger DNA-binding transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MET4 YNL103W Leucine-zipper transcriptional activator regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SPT20 YOL148C Subunit of the SAGA transcriptional regulatory complex regulation 1 1 1 DNA to cDNA expression microarray evidence
XBP1 YIL101C Transcriptional repressor regulation 1 1 1 transcript expression evidence
RAP1 YNL216W Essential DNA-binding transcription regulator that binds many loci regulation 1 1 1 chromatin immunoprecipitation-chip evidence
YAP6 YDR259C Basic leucine zipper (bZIP) transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SIN4 YNL236W Subunit of the RNA polymerase II mediator complex regulation 1 1 1 DNA to cDNA expression microarray evidence
UGA3 YDL170W Transcriptional activator for GABA-dependent induction of GABA genes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MCM1 YMR043W Transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
PHD1 YKL043W Transcriptional activator that enhances pseudohyphal growth regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CDC33 YOL139C Translation initiation factor eIF4E genetic 1 1 1 Synthetic Rescue
CDC48 YDL126C AAA ATPase with protein-unfoldase activity physical 1 1 1 Affinity Capture-Western
CBC2 YPL178W Small subunit of the heterodimeric cap binding complex with Sto1p genetic 1 1 1 Negative Genetic
ACT1 YFL039C Actin, structural protein in cytoskeleton genetic 1 1 1 Negative Genetic
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex genetic 1 1 1 Synthetic Lethality
ARO1 YDR127W Pentafunctional arom protein genetic 1 1 1 Negative Genetic
BEM1 YBR200W Protein containing SH3-domains genetic 1 1 1 Positive Genetic
ASC1 YMR116C G-protein beta subunit and guanine dissociation inhibitor for Gpa2p genetic 1 1 1 Negative Genetic
CDC10 YCR002C Component of the septin ring, required for cytokinesis genetic 1 1 1 Negative Genetic
CDC3 YLR314C Component of the septin ring that is required for cytokinesis genetic 1 1 1 Negative Genetic
CDC55 YGL190C Regulatory subunit B of protein phosphatase 2A (PP2A) genetic 1 1 1 Negative Genetic
CIP1 YPL014W Cyclin-dependent kinase inhibitor physical 1 1 1 Affinity Capture-Western
BCK1 YJL095W MAPKKK acting in the protein kinase C signaling pathway genetic 1 1 1 Dosage Growth Defect
CDC53 YDL132W Cullin physical 1 1 1 Affinity Capture-Western
CDC53 YDL132W Cullin genetic 1 1 1 Dosage Growth Defect
CHK1 YBR274W Serine/threonine kinase and DNA damage checkpoint effector genetic 1 1 1 Negative Genetic
BUL1 YMR275C Alpha-arrestin, component of the Rsp5p E3-ubiquitin ligase complex genetic 1 1 1 Negative Genetic
CDC4 YFL009W F-box protein required for both the G1/S and G2/M phase transitions genetic 1 1 1 Dosage Lethality
CDC15 YAR019C Hippo-like kinase of the Mitotic Exit Network genetic 1 1 1 Phenotypic Suppression
BUB3 YOR026W Kinetochore checkpoint WD40 repeat protein genetic 1 1 1 Negative Genetic
CDH1 YGL003C Activator of anaphase-promoting complex/cyclosome (APC/C) genetic 1 1 1 Phenotypic Enhancement
YDJ1 YNL064C Type I HSP40 co-chaperone physical 1 1 1 Affinity Capture-Western
HEK2 YBL032W RNA binding protein involved in asymmetric localization of ASH1 mRNA physical 1 1 1 Affinity Capture-RNA
SWI6 YLR182W Transcription cofactor physical 1 1 1 Affinity Capture-Western
PRP43 YGL120C RNA helicase in the DEAH-box family physical 1 1 1 Affinity Capture-MS
SRP1 YNL189W Karyopherin alpha homolog physical 1 1 1 Affinity Capture-MS
KIN2 YLR096W S/T protein kinase physical 1 1 1 PCA
PHO80 YOL001W Cyclin physical 1 1 1 Affinity Capture-Western
PHO85 YPL031C Cyclin-dependent kinase physical 1 1 1 Biochemical Activity
PHO85 YPL031C Cyclin-dependent kinase genetic 1 1 1 Synthetic Lethality
SSA1 YAL005C ATPase involved in protein folding and NLS-directed nuclear transport physical 1 1 1 Affinity Capture-Western
SSA2 YLL024C HSP70 family ATP-binding protein physical 1 1 1 Affinity Capture-Western
SSA3 YBL075C ATPase involved in protein folding and the response to stress physical 1 1 1 Affinity Capture-Western
SSA4 YER103W Heat shock protein that is highly induced upon stress physical 1 1 1 Affinity Capture-Western
GRR1 YJR090C F-box protein component of an SCF ubiquitin-ligase complex physical 1 1 1 Affinity Capture-Western
GRR1 YJR090C F-box protein component of an SCF ubiquitin-ligase complex genetic 1 1 1 Dosage Lethality
ISW1 YBR245C ATPase subunit of imitation-switch (ISWI) class chromatin remodelers physical 1 1 1 Affinity Capture-RNA
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator genetic 1 1 1 Dosage Lethality
MPS3 YJL019W Nuclear envelope protein physical 1 1 1 Affinity Capture-MS
SSD1 YDR293C Translational repressor physical 1 1 1 Affinity Capture-RNA
SSD1 YDR293C Translational repressor genetic 1 1 1 Positive Genetic
SIS2 YKR072C Negative regulatory subunit of protein phosphatase 1 (Ppz1p) genetic 1 1 1 Dosage Rescue
NAB3 YPL190C RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p) genetic 1 1 1 Dosage Rescue
RME1 YGR044C Zinc finger protein involved in control of meiosis genetic 1 1 1 Dosage Rescue
STE4 YOR212W G protein beta subunit genetic 1 1 1 Dosage Rescue
STE5 YDR103W Pheromone-responsive MAPK scaffold protein genetic 1 1 1 Dosage Rescue
SAP155 YFR040W Protein required for function of the Sit4p protein phosphatase genetic 1 1 1 Synthetic Growth Defect
SMI1 YGR229C Protein involved in the regulation of cell wall synthesis genetic 1 1 1 Synthetic Lethality
SGV1 YPR161C Cyclin (Bur2p)-dependent protein kinase genetic 1 1 1 Synthetic Rescue
KSS1 YGR040W Mitogen-activated protein kinase (MAPK) genetic 1 1 1 Phenotypic Suppression
GCR1 YPL075W Transcriptional activator of genes involved in glycolysis genetic 1 1 1 Synthetic Lethality
FAR3 YMR052W Protein of unknown function genetic 1 1 1 Synthetic Lethality
HYM1 YKL189W Component of the RAM signaling network genetic 1 1 1 Synthetic Growth Defect
GID8 YMR135C Subunit of GID Complex, binds strongly to central component Vid30p genetic 1 1 1 Phenotypic Enhancement
DCR2 YLR361C Protein phosphatase genetic 1 1 1 Phenotypic Enhancement
POL30 YBR088C Proliferating cell nuclear antigen (PCNA) genetic 1 1 1 Negative Genetic
GAL11 YOL051W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
RVS161 YCR009C Amphiphysin-like lipid raft protein genetic 1 1 1 Negative Genetic
THP1 YOL072W Nuclear pore-associated protein genetic 1 1 1 Negative Genetic
SPT8 YLR055C Subunit of the SAGA transcriptional regulatory complex genetic 1 1 1 Negative Genetic
UBP3 YER151C Ubiquitin-specific protease that cleaves Ub-protein fusions genetic 1 1 1 Negative Genetic
PAT1 YCR077C Deadenylation-dependent mRNA-decapping factor genetic 1 1 1 Negative Genetic
SNT1 YCR033W Set3C histone deacetylase scaffold genetic 1 1 1 Negative Genetic
DDR48 YMR173W DNA damage-responsive protein genetic 1 1 1 Negative Genetic
DPB11 YJL090C DNA replication initiation protein genetic 1 1 1 Negative Genetic
RPB3 YIL021W RNA polymerase II third largest subunit B44 genetic 1 1 1 Positive Genetic
SPT21 YMR179W Protein with a role in transcriptional silencing genetic 1 1 1 Positive Genetic
PFD1 YJL179W Subunit of heterohexameric prefoldin genetic 1 1 1 Positive Genetic
SIR1 YKR101W Protein involved in silencing at mating-type loci HML and HMR genetic 1 1 1 Positive Genetic
YML119W YML119W Putative protein of unknown function genetic 1 1 1 Positive Genetic
CSF1 YLR087C Protein with structural similarity to lipid transport protein Vps13p genetic 1 1 1 Positive Genetic
RSC8 YFR037C Component of the RSC chromatin remodeling complex genetic 1 1 1 Positive Genetic
RGP1 YDR137W Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) genetic 1 1 1 Positive Genetic
NUM1 YDR150W Protein required for nuclear migration genetic 1 1 1 Positive Genetic
YPT6 YLR262C Rab family GTPase genetic 1 1 1 Positive Genetic
PLP2 YOR281C Protein that interacts with the CCT complex to stimulate actin folding genetic 1 1 1 Dosage Rescue
HSP82 YPL240C Hsp90 chaperone genetic 1 1 1 Synthetic Growth Defect
HSC82 YMR186W Cytoplasmic chaperone of the Hsp90 family genetic 1 1 1 Synthetic Growth Defect
PTC1 YDL006W Type 2C protein phosphatase (PP2C) genetic 1 1 1 Negative Genetic
REG1 YDR028C Regulatory subunit of type 1 protein phosphatase Glc7p genetic 1 1 1 Positive Genetic
NBP2 YDR162C Protein involved in the HOG (high osmolarity glycerol) pathway genetic 1 1 1 Negative Genetic
SAC1 YKL212W Phosphatidylinositol phosphate phosphatase genetic 1 1 1 Negative Genetic
PCK1 YKR097W Phosphoenolpyruvate carboxykinase genetic 1 1 1 Positive Genetic
KCS1 YDR017C Inositol hexakisphosphate and inositol heptakisphosphate kinase genetic 1 1 1 Negative Genetic
IPK1 YDR315C Inositol 1,3,4,5,6-pentakisphosphate 2-kinase genetic 1 1 1 Negative Genetic
SWR1 YDR334W Swi2/Snf2-related ATPase genetic 1 1 1 Positive Genetic
STE20 YHL007C Cdc42p-activated signal transducing kinase genetic 1 1 1 Positive Genetic
GIM5 YML094W Subunit of the heterohexameric cochaperone prefoldin complex genetic 1 1 1 Positive Genetic
PLC1 YPL268W Phospholipase C genetic 1 1 1 Negative Genetic
PCL9 YDL179W Cyclin genetic 1 1 1 Dosage Rescue
PCL1 YNL289W Cyclin, interacts with cyclin-dependent kinase Pho85p genetic 1 1 1 Dosage Rescue
HOS3 YPL116W Trichostatin A-insensitive homodimeric histone deacetylase (HDAC) genetic 1 1 1 Synthetic Rescue
FRA1 YLL029W Protein involved in negative regulation of iron regulon transcription genetic 1 1 1 Negative Genetic
VAM10 YOR068C Protein involved in vacuole morphogenesis genetic 1 1 1 Negative Genetic
RTS2 YOR077W Basic zinc-finger protein genetic 1 1 1 Negative Genetic
GPA2 YER020W Nucleotide binding alpha subunit of the heterotrimeric G protein genetic 1 1 1 Phenotypic Enhancement
KAP122 YGL016W Karyopherin beta genetic 1 1 1 Phenotypic Enhancement
TPK2 YPL203W cAMP-dependent protein kinase catalytic subunit genetic 1 1 1 Phenotypic Enhancement
SFP1 YLR403W Regulates transcription of ribosomal protein and biogenesis genes genetic 1 1 1 Phenotypic Enhancement
SKY1 YMR216C SR protein kinase (SRPK) genetic 1 1 1 Phenotypic Enhancement
SSF1 YHR066W Constituent of 66S pre-ribosomal particles genetic 1 1 1 Phenotypic Enhancement
VPS51 YKR020W Component of the GARP (Golgi-associated retrograde protein) complex genetic 1 1 1 Phenotypic Enhancement
MBP1 YDL056W Transcription factor genetic 1 1 1 Phenotypic Suppression
STE11 YLR362W Signal transducing MEK kinase genetic 1 1 1 Phenotypic Enhancement
SRS2 YJL092W DNA helicase and DNA-dependent ATPase genetic 1 1 1 Dosage Lethality
RCK2 YLR248W Protein kinase involved in response to oxidative and osmotic stress genetic 1 1 1 Negative Genetic
DCC1 YCL016C Subunit of a complex with Ctf8p and Ctf18p genetic 1 1 1 Positive Genetic
SOK2 YMR016C Nuclear protein that negatively regulates pseudohyphal differentiation genetic 1 1 1 Negative Genetic
NPR1 YNL183C Protein kinase genetic 1 1 1 Negative Genetic
SKN7 YHR206W Nuclear response regulator and transcription factor genetic 1 1 1 Negative Genetic
RTG3 YBL103C bHLH/Zip transcription factor for retrograde (RTG) and TOR pathways genetic 1 1 1 Negative Genetic
RPL36B YPL249C-A Ribosomal 60S subunit protein L36B genetic 1 1 1 Phenotypic Suppression
RPL42A YNL162W Ribosomal 60S subunit protein L42A genetic 1 1 1 Phenotypic Suppression
CTR9 YOL145C Component of the Paf1p complex involved in transcription elongation genetic 1 1 1 Phenotypic Enhancement
ECM9 YKR004C Non-essential protein of unknown function genetic 1 1 1 Phenotypic Enhancement
SPT10 YJL127C Histone H3 acetylase with a role in transcriptional regulation genetic 1 1 1 Synthetic Rescue
HOG1 YLR113W Mitogen-activated protein kinase involved in osmoregulation genetic 1 1 1 Synthetic Rescue
ELM1 YKL048C Serine/threonine protein kinase genetic 1 1 1 Dosage Growth Defect
PSY2 YNL201C Subunit of protein phosphatase PP4 complex genetic 1 1 1 Negative Genetic
DNF1 YER166W Aminophospholipid translocase (flippase) genetic 1 1 1 Phenotypic Suppression
DNF2 YDR093W Aminophospholipid translocase (flippase) genetic 1 1 1 Phenotypic Suppression
DNF3 YMR162C Trans-golgi network aminophospholipid translocase (flippase) genetic 1 1 1 Phenotypic Suppression
XBP1 YIL101C Transcriptional repressor genetic 1 1 1 Phenotypic Suppression
RAD53 YPL153C DNA damage response kinase genetic 1 1 1 Phenotypic Enhancement
HTB1 YDR224C Histone H2B genetic 1 1 1 Dosage Rescue
HHT2 YNL031C Histone H3 genetic 1 1 1 Dosage Rescue
LCB2 YDR062W Component of serine palmitoyltransferase genetic 1 1 1 Positive Genetic
PBR1 YNL181W Putative oxidoreductase genetic 1 1 1 Positive Genetic
RPL13A YDL082W Ribosomal 60S subunit protein L13A genetic 1 1 1 Positive Genetic
INO2 YDR123C Transcription factor genetic 1 1 1 Positive Genetic
DAL81 YIR023W Positive regulator of genes in multiple nitrogen degradation pathways genetic 1 1 1 Positive Genetic
ILM1 YJR118C Protein of unknown function genetic 1 1 1 Positive Genetic
MRP20 YDR405W Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Positive Genetic
GCN4 YEL009C bZIP transcriptional activator of amino acid biosynthetic genes genetic 1 1 1 Positive Genetic
COX6 YHR051W Subunit VI of cytochrome c oxidase (Complex IV) genetic 1 1 1 Positive Genetic
EOS1 YNL080C Protein involved in N-glycosylation genetic 1 1 1 Positive Genetic
SRB7 YDR308C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
INO80 YGL150C Nucleosome spacing factor genetic 1 1 1 Negative Genetic
UTP8 YGR128C Nucleolar protein required for export of tRNAs from the nucleus genetic 1 1 1 Negative Genetic
DNA2 YHR164C ATP-dependent 5'-flap endonuclease and DNA helicase genetic 1 1 1 Negative Genetic
RFA3 YJL173C Subunit of heterotrimeric Replication Protein A (RPA) genetic 1 1 1 Negative Genetic
FCF2 YLR051C Nucleolar protein involved in the early steps of 35S rRNA processing genetic 1 1 1 Negative Genetic
RGR1 YLR071C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
SMD2 YLR275W Core Sm protein Sm D2 genetic 1 1 1 Negative Genetic
FCP1 YMR277W Carboxy-terminal domain (CTD) phosphatase genetic 1 1 1 Negative Genetic
RFA2 YNL312W Subunit of heterotrimeric Replication Protein A (RPA) genetic 1 1 1 Negative Genetic
OST2 YOR103C Epsilon subunit of the oligosaccharyltransferase complex genetic 1 1 1 Negative Genetic
MED4 YOR174W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
RFC1 YOR217W Subunit of heteropentameric Replication factor C (RF-C) genetic 1 1 1 Negative Genetic
SPC29 YPL124W Inner plaque spindle pole body (SPB) component genetic 1 1 1 Negative Genetic
FHL1 YPR104C Regulator of ribosomal protein (RP) transcription genetic 1 1 1 Negative Genetic
GFD2 YCL036W Protein of unknown function genetic 1 1 1 Negative Genetic
THR4 YCR053W Threonine synthase genetic 1 1 1 Negative Genetic
GPR1 YDL035C Plasma membrane G protein coupled receptor (GPCR) genetic 1 1 1 Negative Genetic
SAC7 YDR389W GTPase activating protein (GAP) for Rho1p genetic 1 1 1 Negative Genetic
SDC1 YDR469W Subunit of the COMPASS (Set1C) complex genetic 1 1 1 Negative Genetic
PSP1 YDR505C Asn and gln rich protein of unknown function genetic 1 1 1 Negative Genetic
NUT1 YGL151W Component of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
HUR1 YGL168W Protein with a role in DNA repair genetic 1 1 1 Negative Genetic
MUP1 YGR055W High affinity methionine permease genetic 1 1 1 Negative Genetic
HTD2 YHR067W Mitochondrial 3-hydroxyacyl-thioester dehydratase genetic 1 1 1 Negative Genetic
NMD2 YHR077C Protein involved in the nonsense-mediated mRNA decay (NMD) pathway genetic 1 1 1 Negative Genetic
POT1 YIL160C 3-ketoacyl-CoA thiolase with broad chain length specificity genetic 1 1 1 Negative Genetic
GTT1 YIR038C ER associated glutathione S-transferase genetic 1 1 1 Negative Genetic
SNX4 YJL036W Sorting nexin genetic 1 1 1 Negative Genetic
RPS21B YJL136C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
RPA34 YJL148W RNA polymerase I subunit A34.5 genetic 1 1 1 Negative Genetic
PIR5 YJL160C Putative protein of unknown function genetic 1 1 1 Negative Genetic
KCH1 YJR054W Potassium transporter that mediates K+ influx genetic 1 1 1 Negative Genetic
LIA1 YJR070C Deoxyhypusine hydroxylase genetic 1 1 1 Negative Genetic
SKA1 YKL023W SKI complex-associated protein genetic 1 1 1 Negative Genetic
TCD2 YKL027W tRNA threonylcarbamoyladenosine dehydratase genetic 1 1 1 Negative Genetic
OAR1 YKL055C Mitochondrial 3-oxoacyl-[acyl-carrier-protein] reductase genetic 1 1 1 Negative Genetic
PSG1 YKL077W Protein that promotes the transport and maturation of Pma1 with Exp1 genetic 1 1 1 Negative Genetic
RAD27 YKL113C 5' to 3' exonuclease, 5' flap endonuclease genetic 1 1 1 Negative Genetic
DBR1 YKL149C RNA lariat debranching enzyme genetic 1 1 1 Negative Genetic
HFL1 YKR051W Vacuole membrane protein that interacts with Atg8p genetic 1 1 1 Negative Genetic
SND2 YLR065C Protein involved in SRP-independent targeting of substrates to the ER genetic 1 1 1 Negative Genetic
PUS5 YLR165C Pseudouridine synthase genetic 1 1 1 Negative Genetic
VTA1 YLR181C Multivesicular body (MVB) protein genetic 1 1 1 Negative Genetic
MMS22 YLR320W Subunit of E3 ubiquitin ligase complex involved in replication repair genetic 1 1 1 Negative Genetic
VIP1 YLR410W Bifunctional inositol pyrophosphate kinase and phosphatase genetic 1 1 1 Negative Genetic
PSP2 YML017W Asn rich cytoplasmic protein that contains RGG motifs genetic 1 1 1 Negative Genetic
VPS9 YML097C Guanine nucleotide exchange factor (GEF) and ubiquitin receptor genetic 1 1 1 Negative Genetic
NUP188 YML103C Subunit of the inner ring of the nuclear pore complex (NPC) genetic 1 1 1 Negative Genetic
IRC21 YMR073C Protein of unknown function genetic 1 1 1 Negative Genetic
NAM7 YMR080C ATP-dependent RNA helicase of the SFI superfamily genetic 1 1 1 Negative Genetic
SCS7 YMR272C Sphingolipid alpha-hydroxylase genetic 1 1 1 Negative Genetic
SIW14 YNL032W Inositol phosphatase involved in inositol pyrophosphate metabolism genetic 1 1 1 Negative Genetic
PHO23 YNL097C Component of the Rpd3L histone deacetylase complex genetic 1 1 1 Negative Genetic
FAR11 YNL127W Protein involved in recovery from cell cycle arrest genetic 1 1 1 Negative Genetic
TRM11 YOL124C Catalytic subunit of adoMet-dependent tRNA methyltransferase complex genetic 1 1 1 Negative Genetic
MRX11 YPL041C Protein that associates with mitochondrial ribosome genetic 1 1 1 Negative Genetic
YTA6 YPL074W Putative ATPase of the CDC48/PAS1/SEC18 (AAA) family genetic 1 1 1 Negative Genetic
RTT10 YPL183C WD40 domain-containing protein involved in endosomal recycling genetic 1 1 1 Negative Genetic
MRPL27 YBR282W Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
VPS60 YDR486C Protein involved in late endosome to vacuole transport genetic 1 1 1 Negative Genetic
MIT1 YEL007W Transcriptional regulator of pseudohyphal growth genetic 1 1 1 Negative Genetic
COQ6 YGR255C Flavin-dependent monooxygenase involved in ubiquinone biosynthesis genetic 1 1 1 Negative Genetic
YJR098C YJR098C Putative protein of unknown function genetic 1 1 1 Negative Genetic
VPS24 YKL041W One of four subunits of the ESCRT-III complex genetic 1 1 1 Negative Genetic
SSO2 YMR183C Plasma membrane t-SNARE genetic 1 1 1 Negative Genetic
CRS5 YOR031W Copper-binding metallothionein genetic 1 1 1 Negative Genetic
STD1 YOR047C Protein involved in control of glucose-regulated gene expression genetic 1 1 1 Negative Genetic
VHS3 YOR054C Negative regulatory subunit of protein phosphatase 1 Ppz1p genetic 1 1 1 Negative Genetic
SKI7 YOR076C GTP-binding protein that couples the Ski complex and exosome genetic 1 1 1 Negative Genetic
TCB1 YOR086C Lipid-binding ER protein involved in ER-plasma membrane tethering genetic 1 1 1 Negative Genetic
VPS21 YOR089C Endosomal Rab family GTPase genetic 1 1 1 Negative Genetic
YNG2 YHR090C Subunit of NuA4, an essential histone acetyltransferase complex genetic 1 1 1 Positive Genetic
ENT4 YLL038C Protein of unknown function genetic 1 1 1 Negative Genetic
NAP1 YKR048C Histone chaperone and assembly chaperone for Rps6a/b genetic 1 1 1 Negative Genetic
SEC27 YGL137W Essential beta'-coat protein of the COPI coatomer genetic 1 1 1 Positive Genetic
MUS81 YDR386W Subunit of structure-specific Mms4p-Mus81p endonuclease genetic 1 1 1 Negative Genetic
RNH1 YMR234W Ribonuclease H1 genetic 1 1 1 Negative Genetic
GSY1 YFR015C Glycogen synthase genetic 1 1 1 Phenotypic Suppression
GSY2 YLR258W Glycogen synthase genetic 1 1 1 Phenotypic Suppression
TPS1 YBR126C Synthase subunit of trehalose-6-P synthase/phosphatase complex genetic 1 1 1 Phenotypic Suppression
AFT1 YGL071W Transcription factor involved in iron utilization and homeostasis genetic 1 1 1 Dosage Rescue
APC5 YOR249C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 1 1 1 Positive Genetic
ARP6 YLR085C Actin-related protein that binds nucleosomes genetic 1 1 1 Positive Genetic
CLB5 YPR120C B-type cyclin involved in DNA replication during S phase genetic 1 1 1 Dosage Rescue
CCS1 YMR038C Copper chaperone for superoxide dismutase Sod1p genetic 1 1 1 Synthetic Growth Defect
CLB3 YDL155W B-type cyclin involved in cell cycle progression genetic 1 1 1 Synthetic Rescue
CCC1 YLR220W Vacuolar Fe2+/Mn2+ transporter genetic 1 1 1 Negative Genetic
ALT1 YLR089C Alanine transaminase (glutamic pyruvic transaminase) genetic 1 1 1 Negative Genetic
ARO2 YGL148W Bifunctional chorismate synthase and flavin reductase genetic 1 1 1 Negative Genetic
CLB6 YGR109C B-type cyclin involved in DNA replication during S phase genetic 1 1 1 Phenotypic Enhancement
ATX2 YOR079C Golgi membrane protein involved in manganese homeostasis genetic 1 1 1 Negative Genetic
APQ12 YIL040W Nuclear envelope/ER integral membrane protein genetic 1 1 1 Positive Genetic