Standard name Systematic name Name description Description
STE4 YOR212W G protein beta subunit G protein beta subunit; forms a dimer with Ste18p to activate mating signaling pathway, forms heterotrimer with Gpa1p and Ste18p to dampen signaling; pheromone-induced phosphorylation plays critical role in chemotropism; may recruit Rho1p to polarized growth site during mating; contains WD40 repeats
Visualize the interactome of STE4
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Cell Periphery NaN NaN 0.263
Cytoplasm NaN NaN 0.926

GFP localization & abundance

GFP localization GFP abundance
cytoplasm 2050

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
STE4 0 0 0 3 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
GPA1 YHR005C Subunit of G protein involved in pheromone response physical 20 5 18 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Two-hybrid, Two-hybrid, Two-hybrid, Reconstituted Complex, Affinity Capture-Western, Two-hybrid, Affinity Capture-Western, Reconstituted Complex, Two-hybrid, Two-hybrid, Co-purification, Affinity Capture-Western, Two-hybrid, Two-hybrid, Affinity Capture-Western, Two-hybrid, Affinity Capture-Western
STE5 YDR103W Pheromone-responsive MAPK scaffold protein physical 11 4 9 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Two-hybrid, Two-hybrid, Two-hybrid, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex
STE18 YJR086W G protein gamma subunit physical 9 5 9 Two-hybrid, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Two-hybrid, Two-hybrid, Two-hybrid, PCA, Reconstituted Complex
STE5 YDR103W Pheromone-responsive MAPK scaffold protein genetic 8 5 6 Dosage Rescue, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Rescue, Synthetic Rescue, Synthetic Lethality, Phenotypic Suppression, Phenotypic Suppression
CDC24 YAL041W Guanine nucleotide exchange factor (GEF) for Cdc42p physical 8 3 6 Reconstituted Complex, Reconstituted Complex, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Affinity Capture-Western, Two-hybrid
STE18 YJR086W G protein gamma subunit genetic 7 4 6 Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Rescue, Synthetic Rescue, Dosage Rescue, Phenotypic Suppression
GPA1 YHR005C Subunit of G protein involved in pheromone response genetic 4 3 4 Synthetic Rescue, Synthetic Rescue, Dosage Growth Defect, Synthetic Growth Defect
FAR1 YJL157C CDK inhibitor and nuclear anchor physical 4 3 3 Affinity Capture-Western, Reconstituted Complex, Two-hybrid, Two-hybrid
AKR1 YDR264C Palmitoyl transferase involved in protein palmitoylation physical 4 2 3 Two-hybrid, Two-hybrid, Affinity Capture-MS, Affinity Capture-MS
FUS3 YBL016W Mitogen-activated serine/threonine protein kinase involved in mating genetic 3 3 3 Phenotypic Enhancement, Synthetic Rescue, Phenotypic Suppression
STE11 YLR362W Signal transducing MEK kinase genetic 3 3 3 Phenotypic Enhancement, Synthetic Rescue, Phenotypic Suppression
STE2 YFL026W Receptor for alpha-factor pheromone genetic 3 2 3 Dosage Rescue, Dosage Rescue, Dosage Growth Defect
STE20 YHL007C Cdc42p-activated signal transducing kinase genetic 3 3 2 Phenotypic Enhancement, Synthetic Rescue, Dosage Rescue
STE20 YHL007C Cdc42p-activated signal transducing kinase physical 3 2 2 Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western
SSF1 YHR066W Constituent of 66S pre-ribosomal particles genetic 2 2 2 Dosage Rescue, Phenotypic Suppression
HOG1 YLR113W Mitogen-activated protein kinase involved in osmoregulation genetic 2 2 2 Phenotypic Suppression, Dosage Growth Defect
TEC1 YBR083W Transcription factor targeting filamentation genes and Ty1 expression genetic 2 2 2 Synthetic Rescue, Phenotypic Enhancement
STE7 YDL159W Signal transducing MAP kinase kinase genetic 2 2 2 Synthetic Rescue, Phenotypic Suppression
RGA1 YOR127W GTPase-activating protein for polarity-regulator Cdc42p (RhoGAP) genetic 2 2 2 Phenotypic Enhancement, Synthetic Rescue
SST2 YLR452C GTPase-activating protein for Gpa1p genetic 2 2 2 Synthetic Rescue, Phenotypic Suppression
RHO1 YPR165W GTP-binding protein of the rho subfamily of Ras-like proteins genetic 2 1 2 Dosage Rescue, Dosage Rescue
STE50 YCL032W Adaptor protein for various signaling pathways physical 2 1 2 Two-hybrid, Two-hybrid
STE2 YFL026W Receptor for alpha-factor pheromone physical 2 1 2 Two-hybrid, Two-hybrid
RSP5 YER125W NEDD4 family E3 ubiquitin ligase physical 2 2 1 Affinity Capture-Western, Biochemical Activity
YCK1 YHR135C Palmitoylated plasma membrane-bound casein kinase I (CK1) isoform physical 2 2 1 Affinity Capture-Western, PCA
MDG1 YNL173C Plasma membrane protein genetic 2 2 1 Dosage Rescue, Phenotypic Enhancement
RPD3 YNL330C Histone deacetylase, component of both the Rpd3S and Rpd3L complexes genetic 2 1 1 Dosage Lethality, Dosage Lethality
FKH1 YIL131C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
IXR1 YKL032C Transcriptional repressor that regulates hypoxic genes during normoxia regulation 1 1 1 DNA to cDNA expression microarray evidence
FKH2 YNL068C Forkhead family transcription factor regulation 1 1 1 ChEC-Seq experiments
FHL1 YPR104C Regulator of ribosomal protein (RP) transcription regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SIR2 YDL042C Conserved NAD+ dependent histone deacetylase of the Sirtuin family regulation 1 1 1 RNA-sequencing evidence
SIR3 YLR442C Silencing protein regulation 1 1 1 RNA-sequencing evidence
SIR4 YDR227W SIR protein involved in assembly of silent chromatin domains regulation 1 1 1 RNA-sequencing evidence
MTR4 YJL050W RNA duplex-sensing translocase physical 1 1 1 Affinity Capture-MS
SAP185 YJL098W Protein that forms a complex with the Sit4p protein phosphatase genetic 1 1 1 Dosage Rescue
GCD11 YER025W Gamma subunit of the translation initiation factor eIF2 physical 1 1 1 Affinity Capture-MS
CDC39 YCR093W Subunit of the CCR4-NOT1 core complex genetic 1 1 1 Synthetic Rescue
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-RNA
ARP2 YDL029W Essential component of the Arp2/3 complex physical 1 1 1 Affinity Capture-MS
BEM1 YBR200W Protein containing SH3-domains genetic 1 1 1 Dosage Rescue
CDC36 YDL165W Component of the CCR4-NOT core complex, involved in mRNA decapping genetic 1 1 1 Synthetic Rescue
ESP1 YGR098C Separase/separin, a caspase-like cysteine protease genetic 1 1 1 Dosage Growth Defect
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
KIN3 YAR018C Nonessential serine/threonine protein kinase physical 1 1 1 Two-hybrid
AHA1 YDR214W Co-chaperone that binds Hsp82p and activates its ATPase activity physical 1 1 1 Affinity Capture-MS
RAD23 YEL037C Protein with ubiquitin-like N terminus genetic 1 1 1 Dosage Growth Defect
CCT2 YIL142W Subunit beta of the cytosolic chaperonin Cct ring complex physical 1 1 1 Affinity Capture-MS
CCT6 YDR188W Subunit of the cytosolic chaperonin Cct ring complex physical 1 1 1 Affinity Capture-MS
SBP1 YHL034C Protein that binds eIF4G and has a role in repression of translation physical 1 1 1 Affinity Capture-RNA
PUF3 YLL013C Protein of the mitochondrial outer surface physical 1 1 1 Affinity Capture-RNA
PPQ1 YPL179W Protein phosphatase that regulates the mating response genetic 1 1 1 Dosage Rescue
CNB1 YKL190W Calcineurin B genetic 1 1 1 Dosage Rescue
SEC53 YFL045C Phosphomannomutase physical 1 1 1 Affinity Capture-MS
CCT5 YJR064W Subunit of the cytosolic chaperonin Cct ring complex physical 1 1 1 Affinity Capture-MS
PGM2 YMR105C Phosphoglucomutase physical 1 1 1 Affinity Capture-MS
FAR1 YJL157C CDK inhibitor and nuclear anchor genetic 1 1 1 Phenotypic Suppression
RHO1 YPR165W GTP-binding protein of the rho subfamily of Ras-like proteins physical 1 1 1 Affinity Capture-Western
CCT3 YJL014W Subunit of the cytosolic chaperonin Cct ring complex physical 1 1 1 Affinity Capture-MS
ELM1 YKL048C Serine/threonine protein kinase genetic 1 1 1 Phenotypic Suppression
RNQ1 YCL028W [PIN(+)] prion physical 1 1 1 Affinity Capture-MS
DSK2 YMR276W Nuclear-enriched ubiquitin-like polyubiquitin-binding protein genetic 1 1 1 Dosage Growth Defect
LTP1 YPR073C Protein phosphotyrosine phosphatase of unknown cellular role genetic 1 1 1 Dosage Rescue
STE12 YHR084W Transcription factor that is activated by a MAPK signaling cascade genetic 1 1 1 Dosage Rescue
ADE17 YMR120C Enzyme of 'de novo' purine biosynthesis physical 1 1 1 Affinity Capture-MS
KSS1 YGR040W Mitogen-activated protein kinase (MAPK) genetic 1 1 1 Phenotypic Enhancement
PTP2 YOR208W Phosphotyrosine-specific phosphatase genetic 1 1 1 Dosage Rescue
PTC2 YER089C Type 2C protein phosphatase (PP2C) genetic 1 1 1 Dosage Rescue
MSG5 YNL053W Dual-specificity protein phosphatase genetic 1 1 1 Dosage Rescue
TCP1 YDR212W Alpha subunit of chaperonin-containing T-complex physical 1 1 1 Affinity Capture-MS
YHR033W YHR033W Putative protein of unknown function physical 1 1 1 Affinity Capture-MS
STE50 YCL032W Adaptor protein for various signaling pathways genetic 1 1 1 Dosage Rescue
SYG1 YIL047C Plasma membrane protein of unknown function physical 1 1 1 Two-hybrid
SYG1 YIL047C Plasma membrane protein of unknown function genetic 1 1 1 Dosage Rescue
YAF9 YNL107W Subunit of NuA4 histone H4 acetyltransferase and SWR1 complexes physical 1 1 1 Two-hybrid
STV1 YMR054W Subunit a of the vacuolar-ATPase V0 domain physical 1 1 1 Two-hybrid
YCK1 YHR135C Palmitoylated plasma membrane-bound casein kinase I (CK1) isoform genetic 1 1 1 Dosage Rescue
CLN2 YPL256C G1 cyclin involved in regulation of the cell cycle genetic 1 1 1 Synthetic Rescue
CLN3 YAL040C G1 cyclin involved in cell cycle progression genetic 1 1 1 Dosage Rescue
MSN5 YDR335W Karyopherin genetic 1 1 1 Phenotypic Enhancement
NUF2 YOL069W Component of the kinetochore-associated Ndc80 complex physical 1 1 1 Two-hybrid
PKC1 YBL105C Protein serine/threonine kinase genetic 1 1 1 Phenotypic Suppression
OCA2 YNL056W Protein of unknown function genetic 1 1 1 Dosage Rescue
SKO1 YNL167C Basic leucine zipper transcription factor of the ATF/CREB family genetic 1 1 1 Phenotypic Suppression
MCM1 YMR043W Transcription factor genetic 1 1 1 Dosage Rescue
MOT2 YER068W Ubiquitin-protein ligase subunit of the CCR4-NOT complex genetic 1 1 1 Synthetic Rescue
SEC61 YLR378C Conserved ER protein translocation channel physical 1 1 1 Affinity Capture-MS
SSO1 YPL232W Plasma membrane t-SNARE physical 1 1 1 Two-hybrid
FCP1 YMR277W Carboxy-terminal domain (CTD) phosphatase genetic 1 1 1 Dosage Rescue
AKR1 YDR264C Palmitoyl transferase involved in protein palmitoylation genetic 1 1 1 Dosage Rescue
DSE1 YER124C Daughter cell-specific protein physical 1 1 1 Affinity Capture-Western
DSE1 YER124C Daughter cell-specific protein genetic 1 1 1 Dosage Rescue
RSR1 YGR152C Ras-type GTPase genetic 1 1 1 Phenotypic Enhancement
PMT4 YJR143C Protein O-mannosyltransferase genetic 1 1 1 Phenotypic Enhancement
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
MOG1 YJR074W Conserved nuclear protein that interacts with GTP-Gsp1p physical 1 1 1 Affinity Capture-MS
DPM1 YPR183W Dolichol phosphate mannose (Dol-P-Man) synthase of ER membrane genetic 1 1 1 Synthetic Rescue
POG1 YIL122W DNA-binding transcriptional activator genetic 1 1 1 Dosage Rescue
PLP1 YDR183W Protein that interacts with CCT (chaperonin containing TCP-1) complex physical 1 1 1 Reconstituted Complex
PLP2 YOR281C Protein that interacts with the CCT complex to stimulate actin folding physical 1 1 1 Reconstituted Complex
BAR1 YIL015W Aspartyl protease secreted to periplasmic space of mating type a cell genetic 1 1 1 Synthetic Rescue
APJ1 YNL077W Hsp40 chaperone with a role in SUMO-mediated protein degradation physical 1 1 1 Affinity Capture-MS
PTP1 YDL230W Phosphotyrosine-specific protein phosphatase genetic 1 1 1 Dosage Rescue
SSF2 YDR312W Protein required for ribosomal large subunit maturation genetic 1 1 1 Phenotypic Suppression
STE3 YKL178C Receptor for a factor pheromone genetic 1 1 1 Dosage Rescue