STE4 |
YOR212W |
G protein beta subunit |
physical |
20 |
5 |
18 |
Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Two-hybrid, Two-hybrid, Two-hybrid, Reconstituted Complex, Affinity Capture-Western, Two-hybrid, Affinity Capture-Western, Reconstituted Complex, Two-hybrid, Two-hybrid, Co-purification, Affinity Capture-Western, Two-hybrid, Two-hybrid, Affinity Capture-Western, Two-hybrid, Affinity Capture-Western |
SST2 |
YLR452C |
GTPase-activating protein for Gpa1p |
physical |
7 |
4 |
5 |
Affinity Capture-Western, Biochemical Activity, Biochemical Activity, Reconstituted Complex, Affinity Capture-Western, Co-fractionation, Affinity Capture-Western |
STE2 |
YFL026W |
Receptor for alpha-factor pheromone |
physical |
5 |
4 |
4 |
Two-hybrid, Affinity Capture-Western, Two-hybrid, PCA, FRET |
FUS3 |
YBL016W |
Mitogen-activated serine/threonine protein kinase involved in mating |
physical |
5 |
3 |
3 |
Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Co-localization, Affinity Capture-Western |
FUS3 |
YBL016W |
Mitogen-activated serine/threonine protein kinase involved in mating |
genetic |
4 |
3 |
4 |
Synthetic Rescue, Synthetic Rescue, Phenotypic Suppression, Phenotypic Enhancement |
STE4 |
YOR212W |
G protein beta subunit |
genetic |
4 |
3 |
4 |
Synthetic Rescue, Synthetic Rescue, Dosage Growth Defect, Synthetic Growth Defect |
FKH2 |
YNL068C |
Forkhead family transcription factor |
regulation |
3 |
2 |
3 |
chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation-chip evidence, ChEC-Seq experiments |
STE18 |
YJR086W |
G protein gamma subunit |
physical |
3 |
2 |
3 |
Affinity Capture-Western, Affinity Capture-Western, FRET |
SST2 |
YLR452C |
GTPase-activating protein for Gpa1p |
genetic |
3 |
2 |
3 |
Dosage Rescue, Dosage Rescue, Phenotypic Suppression |
VPS15 |
YBR097W |
Serine/threonine protein kinase involved in vacuolar protein sorting |
physical |
3 |
2 |
2 |
Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western |
GET3 |
YDL100C |
Guanine nucleotide exchange factor for Gpa1p |
physical |
3 |
3 |
1 |
Affinity Capture-Western, Reconstituted Complex, Biochemical Activity |
KAR3 |
YPR141C |
Minus-end-directed microtubule motor |
physical |
3 |
2 |
1 |
Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western |
STE2 |
YFL026W |
Receptor for alpha-factor pheromone |
genetic |
2 |
2 |
2 |
Synthetic Rescue, Dosage Rescue |
STE11 |
YLR362W |
Signal transducing MEK kinase |
genetic |
2 |
2 |
2 |
Synthetic Rescue, Phenotypic Suppression |
FKH1 |
YIL131C |
Forkhead family transcription factor |
regulation |
2 |
1 |
2 |
chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation-chip evidence |
REG1 |
YDR028C |
Regulatory subunit of type 1 protein phosphatase Glc7p |
physical |
2 |
1 |
2 |
Affinity Capture-Western, Affinity Capture-Western |
ELM1 |
YKL048C |
Serine/threonine protein kinase |
physical |
2 |
2 |
1 |
Biochemical Activity, Affinity Capture-Western |
VPS34 |
YLR240W |
Phosphatidylinositol (PI) 3-kinase that synthesizes PI-3-phosphate |
physical |
2 |
2 |
1 |
Affinity Capture-Western, Reconstituted Complex |
SAK1 |
YER129W |
Upstream serine/threonine kinase for the SNF1 complex |
physical |
2 |
2 |
1 |
Affinity Capture-Western, Biochemical Activity |
SFP1 |
YLR403W |
Regulates transcription of ribosomal protein and biogenesis genes |
regulation |
1 |
1 |
1 |
DNA to cDNA expression microarray evidence |
STE12 |
YHR084W |
Transcription factor that is activated by a MAPK signaling cascade |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
IXR1 |
YKL032C |
Transcriptional repressor that regulates hypoxic genes during normoxia |
regulation |
1 |
1 |
1 |
DNA to cDNA expression microarray evidence |
RFX1 |
YLR176C |
Major transcriptional repressor of DNA-damage-regulated genes |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
HFI1 |
YPL254W |
Adaptor protein required for structural integrity of the SAGA complex |
regulation |
1 |
1 |
1 |
DNA to cDNA expression microarray evidence |
SPT20 |
YOL148C |
Subunit of the SAGA transcriptional regulatory complex |
regulation |
1 |
1 |
1 |
DNA to cDNA expression microarray evidence |
MED4 |
YOR174W |
Subunit of the RNA polymerase II mediator complex |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
TUP1 |
YCR084C |
General repressor of transcription in complex with Cyc8p |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
SIR2 |
YDL042C |
Conserved NAD+ dependent histone deacetylase of the Sirtuin family |
regulation |
1 |
1 |
1 |
RNA-sequencing evidence |
SIR3 |
YLR442C |
Silencing protein |
regulation |
1 |
1 |
1 |
RNA-sequencing evidence |
SIR4 |
YDR227W |
SIR protein involved in assembly of silent chromatin domains |
regulation |
1 |
1 |
1 |
RNA-sequencing evidence |
CDC73 |
YLR418C |
Component of the Paf1p complex |
regulation |
1 |
1 |
1 |
DNA to cDNA expression microarray evidence |
SIN3 |
YOL004W |
Component of both the Rpd3S and Rpd3L histone deacetylase complexes |
regulation |
1 |
1 |
1 |
DNA to cDNA expression microarray evidence |
MCM1 |
YMR043W |
Transcription factor |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
PUT3 |
YKL015W |
Transcriptional activator |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
CCR4 |
YAL021C |
Component of the CCR4-NOT transcriptional complex |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
DHH1 |
YDL160C |
Cytoplasmic DEAD-box helicase and mRNA decapping activator |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
CMR1 |
YDL156W |
Nuclear protein with role in transcription, protein quality control |
genetic |
1 |
1 |
1 |
Negative Genetic |
BCY1 |
YIL033C |
Regulatory subunit of the cyclic AMP-dependent protein kinase (PKA) |
physical |
1 |
1 |
1 |
PCA |
FAR1 |
YJL157C |
CDK inhibitor and nuclear anchor |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
CDC4 |
YFL009W |
F-box protein required for both the G1/S and G2/M phase transitions |
physical |
1 |
1 |
1 |
Biochemical Activity |
GPA2 |
YER020W |
Nucleotide binding alpha subunit of the heterotrimeric G protein |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
GPA2 |
YER020W |
Nucleotide binding alpha subunit of the heterotrimeric G protein |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
SCP160 |
YJL080C |
Essential RNA-binding G protein effector of mating response pathway |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
UBP12 |
YJL197W |
Ubiquitin-specific protease |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
RGS2 |
YOR107W |
Negative regulator of glucose-induced cAMP signaling |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
MDM1 |
YML104C |
PtdIns-3-P binding protein that tethers the ER to vacuoles at NVJs |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
RAX1 |
YOR301W |
Protein involved in establishing bud site selection |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
SPC110 |
YDR356W |
Inner plaque spindle pole body (SPB) component |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
MDM31 |
YHR194W |
Mitochondrial protein that may have a role in phospholipid metabolism |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
NAT4 |
YMR069W |
N alpha-acetyl-transferase |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
NCS2 |
YNL119W |
Protein required for uridine thiolation of Lys(UUU) and Glu(UUC) tRNAs |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
KAR3 |
YPR141C |
Minus-end-directed microtubule motor |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
MET30 |
YIL046W |
F-box protein containing five copies of the WD40 motif |
physical |
1 |
1 |
1 |
Two-hybrid |
NAB2 |
YGL122C |
Nuclear polyadenylated RNA-binding protein |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
GPA1 |
YHR005C |
Subunit of G protein involved in pheromone response |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
PUF3 |
YLL013C |
Protein of the mitochondrial outer surface |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
RET1 |
YOR207C |
Second-largest subunit of RNA polymerase III |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
SEC61 |
YLR378C |
Conserved ER protein translocation channel |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
SYG1 |
YIL047C |
Plasma membrane protein of unknown function |
genetic |
1 |
1 |
1 |
Dosage Rescue |
SCH9 |
YHR205W |
AGC family protein kinase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
RAM1 |
YDL090C |
Beta subunit of the CAAX farnesyltransferase (FTase) |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
SGV1 |
YPR161C |
Cyclin (Bur2p)-dependent protein kinase |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
STE5 |
YDR103W |
Pheromone-responsive MAPK scaffold protein |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
STE7 |
YDL159W |
Signal transducing MAP kinase kinase |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
STE12 |
YHR084W |
Transcription factor that is activated by a MAPK signaling cascade |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
RPN4 |
YDL020C |
Transcription factor that stimulates expression of proteasome genes |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
RPN2 |
YIL075C |
Subunit of the 26S proteasome |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
MATALPHA1 |
YCR040W |
Transcriptional co-activator that regulates mating-type-specific genes |
genetic |
1 |
1 |
1 |
Dosage Rescue |
STE3 |
YKL178C |
Receptor for a factor pheromone |
genetic |
1 |
1 |
1 |
Dosage Rescue |
GPR1 |
YDL035C |
Plasma membrane G protein coupled receptor (GPCR) |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
SGS1 |
YMR190C |
RecQ family nucleolar DNA helicase |
genetic |
1 |
1 |
1 |
Negative Genetic |
HRQ1 |
YDR291W |
3'-5' DNA helicase of the conserved RecQ family |
genetic |
1 |
1 |
1 |
Negative Genetic |
CLN2 |
YPL256C |
G1 cyclin involved in regulation of the cell cycle |
genetic |
1 |
1 |
1 |
Dosage Rescue |
BFR1 |
YOR198C |
Component of mRNP complexes associated with polyribosomes |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
BUB1 |
YGR188C |
Protein kinase involved in the cell cycle checkpoint into anaphase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
AKR1 |
YDR264C |
Palmitoyl transferase involved in protein palmitoylation |
genetic |
1 |
1 |
1 |
Synthetic Lethality |