Standard name Systematic name Name description Description
STE11 YLR362W Signal transducing MEK kinase Signal transducing MEK kinase; involved in pheromone response and pseudohyphal/invasive growth pathways where it phosphorylates Ste7p, and the high osmolarity response pathway, via phosphorylation of Pbs2p; regulated by Ste20p and Ste50p; protein abundance increases in response to DNA replication stress
Visualize the interactome of STE11
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.985 0.973 0.991
Cell Periphery NaN NaN 0.096

GFP localization & abundance

GFP localization GFP abundance
cytoplasm 736

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
STE11 2 0 0 9 0

Enzyme information

Catalyzed reactions in Yeast8

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
STE50 YCL032W Adaptor protein for various signaling pathways physical 36 8 26 Two-hybrid, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Two-hybrid, Two-hybrid, Two-hybrid, Biochemical Activity, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Reconstituted Complex, Two-hybrid, Two-hybrid, Reconstituted Complex, Co-crystal Structure, Affinity Capture-MS, Reconstituted Complex, Reconstituted Complex, PCA, FRET, PCA, PCA, Affinity Capture-Western
STE5 YDR103W Pheromone-responsive MAPK scaffold protein physical 21 7 16 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Two-hybrid, Two-hybrid, Affinity Capture-Western, Two-hybrid, Co-fractionation, FRET, FRET, PCA, Co-purification, Two-hybrid, Two-hybrid
STE11 YLR362W Signal transducing MEK kinase physical 12 5 12 Affinity Capture-Western, Two-hybrid, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Two-hybrid, Two-hybrid, Co-crystal Structure, Reconstituted Complex, Co-crystal Structure, PCA, Two-hybrid
SSK1 YLR006C Cytoplasmic phosphorelay intermediate osmosensor and regulator genetic 9 3 7 Phenotypic Enhancement, Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect
SHO1 YER118C Transmembrane osmosensor for filamentous growth and HOG pathways physical 7 4 4 Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western, PCA, Two-hybrid
FUS3 YBL016W Mitogen-activated serine/threonine protein kinase involved in mating physical 6 5 6 Reconstituted Complex, Two-hybrid, Affinity Capture-Western, Co-fractionation, FRET, Two-hybrid
PBS2 YJL128C MAP kinase kinase of the HOG signaling pathway physical 6 4 5 Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Biochemical Activity, Two-hybrid, PCA
STE7 YDL159W Signal transducing MAP kinase kinase physical 6 4 5 Affinity Capture-Western, Biochemical Activity, FRET, FRET, Two-hybrid, Two-hybrid
STE20 YHL007C Cdc42p-activated signal transducing kinase genetic 6 3 5 Phenotypic Enhancement, Phenotypic Suppression, Phenotypic Suppression, Dosage Rescue, Phenotypic Suppression, Phenotypic Suppression
HSP82 YPL240C Hsp90 chaperone physical 5 3 5 Affinity Capture-Western, Affinity Capture-Western, Two-hybrid, Reconstituted Complex, Affinity Capture-Western
STE12 YHR084W Transcription factor that is activated by a MAPK signaling cascade genetic 5 3 5 Synthetic Rescue, Dosage Rescue, Phenotypic Suppression, Phenotypic Suppression, Phenotypic Suppression
KSS1 YGR040W Mitogen-activated protein kinase (MAPK) physical 5 4 4 Affinity Capture-MS, Reconstituted Complex, Two-hybrid, Two-hybrid, PCA
CDC37 YDR168W Essential Hsp90p co-chaperone physical 4 2 4 Affinity Capture-Western, Affinity Capture-Western, Two-hybrid, Affinity Capture-Western
STE50 YCL032W Adaptor protein for various signaling pathways genetic 4 3 3 Dosage Rescue, Synthetic Rescue, Dosage Rescue, Phenotypic Enhancement
STE5 YDR103W Pheromone-responsive MAPK scaffold protein genetic 4 3 3 Phenotypic Enhancement, Synthetic Rescue, Phenotypic Suppression, Phenotypic Enhancement
STE4 YOR212W G protein beta subunit genetic 3 3 3 Phenotypic Enhancement, Synthetic Rescue, Phenotypic Suppression
FUS3 YBL016W Mitogen-activated serine/threonine protein kinase involved in mating genetic 3 1 3 Phenotypic Suppression, Phenotypic Suppression, Phenotypic Suppression
STE20 YHL007C Cdc42p-activated signal transducing kinase physical 3 1 3 Biochemical Activity, Biochemical Activity, Biochemical Activity
BCK1 YJL095W MAPKKK acting in the protein kinase C signaling pathway genetic 3 3 2 Synthetic Rescue, Phenotypic Suppression, Phenotypic Enhancement
HSC82 YMR186W Cytoplasmic chaperone of the Hsp90 family physical 2 2 2 Affinity Capture-Western, Reconstituted Complex
SSK2 YNR031C MAP kinase kinase kinase of HOG1 mitogen-activated signaling pathway genetic 2 2 2 Phenotypic Enhancement, Synthetic Lethality
KSS1 YGR040W Mitogen-activated protein kinase (MAPK) genetic 2 2 2 Phenotypic Enhancement, Phenotypic Suppression
GPA1 YHR005C Subunit of G protein involved in pheromone response genetic 2 2 2 Synthetic Rescue, Phenotypic Suppression
CLN2 YPL256C G1 cyclin involved in regulation of the cell cycle genetic 2 2 2 Dosage Rescue, Phenotypic Enhancement
BNI1 YNL271C Formin genetic 2 1 2 Phenotypic Suppression, Phenotypic Suppression
SPH1 YLR313C Protein involved in shmoo formation and bipolar bud site selection physical 2 1 2 Two-hybrid, Two-hybrid
HOG1 YLR113W Mitogen-activated protein kinase involved in osmoregulation genetic 2 1 2 Phenotypic Suppression, Phenotypic Suppression
PTP2 YOR208W Phosphotyrosine-specific phosphatase genetic 2 1 2 Synthetic Rescue, Synthetic Rescue
DSE1 YER124C Daughter cell-specific protein physical 2 1 2 Two-hybrid, Two-hybrid
BEM4 YPL161C Protein involved in establishment of cell polarity and bud emergence physical 2 2 1 Two-hybrid, Reconstituted Complex
MCM1 YMR043W Transcription factor genetic 2 2 1 Phenotypic Enhancement, Phenotypic Suppression
MKK1 YOR231W MAPKK involved in the protein kinase C signaling pathway physical 2 2 1 Affinity Capture-Western, Biochemical Activity
SST2 YLR452C GTPase-activating protein for Gpa1p genetic 2 2 1 Phenotypic Suppression, Phenotypic Enhancement
ELP3 YPL086C Subunit of Elongator complex genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
BUD6 YLR319C Actin- and formin-interacting protein physical 2 1 1 Two-hybrid, Two-hybrid
SFP1 YLR403W Regulates transcription of ribosomal protein and biogenesis genes regulation 1 1 1 DNA to cDNA expression microarray evidence
TFC7 YOR110W RNA pol III transcription initiation factor complex (TFIIIC) subunit regulation 1 1 1 chromatin immunoprecipitation-chip evidence
ALD3 YMR169C Cytoplasmic aldehyde dehydrogenase regulation 1 1 1 northern blot evidence
CTT1 YGR088W Cytosolic catalase T regulation 1 1 1 northern blot evidence
HHF2 YNL030W Histone H4 regulation 1 1 1 protein kinase assay evidence
HHF1 YBR009C Histone H4 regulation 1 1 1 protein kinase assay evidence
PBS2 YJL128C MAP kinase kinase of the HOG signaling pathway regulation 1 1 1 qualitative western immunoblotting evidence
STE7 YDL159W Signal transducing MAP kinase kinase regulation 1 1 1 tryptic phosphopeptide mapping assay evidence
CKA1 YIL035C Alpha catalytic subunit of casein kinase 2 (CK2) physical 1 1 1 Affinity Capture-MS
LSM1 YJL124C Lsm (Like Sm) protein physical 1 1 1 Two-hybrid
LSM1 YJL124C Lsm (Like Sm) protein genetic 1 1 1 Phenotypic Suppression
PAT1 YCR077C Deadenylation-dependent mRNA-decapping factor genetic 1 1 1 Phenotypic Suppression
PAB1 YER165W Poly(A) binding protein physical 1 1 1 Affinity Capture-MS
RPC19 YNL113W RNA polymerase subunit AC19 physical 1 1 1 Reconstituted Complex
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
CDC39 YCR093W Subunit of the CCR4-NOT1 core complex genetic 1 1 1 Phenotypic Suppression
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-RNA
HGH1 YGR187C Chaperone protein for translation factor eEF2 physical 1 1 1 Reconstituted Complex
BEM1 YBR200W Protein containing SH3-domains physical 1 1 1 Affinity Capture-Western
CDC55 YGL190C Regulatory subunit B of protein phosphatase 2A (PP2A) genetic 1 1 1 Phenotypic Suppression
GDI1 YER136W GDP dissociation inhibitor physical 1 1 1 Affinity Capture-MS
HHF1 YBR009C Histone H4 physical 1 1 1 Biochemical Activity
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
CRM1 YGR218W Nuclear export factor, exportin physical 1 1 1 Affinity Capture-MS
LCB2 YDR062W Component of serine palmitoyltransferase genetic 1 1 1 Phenotypic Suppression
HSP82 YPL240C Hsp90 chaperone genetic 1 1 1 Phenotypic Suppression
EGD2 YHR193C Alpha subunit of the nascent polypeptide-associated complex (NAC) genetic 1 1 1 Synthetic Growth Defect
CRZ1 YNL027W Transcription factor, activates transcription of stress response genes genetic 1 1 1 Phenotypic Suppression
CAF20 YOR276W Phosphoprotein of the mRNA cap-binding complex physical 1 1 1 Affinity Capture-RNA
CNB1 YKL190W Calcineurin B genetic 1 1 1 Phenotypic Suppression
PBS2 YJL128C MAP kinase kinase of the HOG signaling pathway genetic 1 1 1 Phenotypic Suppression
CLN1 YMR199W G1 cyclin involved in regulation of the cell cycle genetic 1 1 1 Phenotypic Suppression
GPD1 YDL022W NAD-dependent glycerol-3-phosphate dehydrogenase genetic 1 1 1 Dosage Rescue
FAR1 YJL157C CDK inhibitor and nuclear anchor genetic 1 1 1 Phenotypic Suppression
ELM1 YKL048C Serine/threonine protein kinase genetic 1 1 1 Phenotypic Suppression
PTP3 YER075C Phosphotyrosine-specific protein phosphatase genetic 1 1 1 Synthetic Rescue
HOG1 YLR113W Mitogen-activated protein kinase involved in osmoregulation physical 1 1 1 PCA
RAS2 YNL098C GTP-binding protein genetic 1 1 1 Dosage Rescue
SLT2 YHR030C Serine/threonine MAP kinase genetic 1 1 1 Phenotypic Suppression
BEM4 YPL161C Protein involved in establishment of cell polarity and bud emergence genetic 1 1 1 Phenotypic Suppression
CLB2 YPR119W B-type cyclin involved in cell cycle progression genetic 1 1 1 Phenotypic Enhancement
PMI40 YER003C Mannose-6-phosphate isomerase genetic 1 1 1 Synthetic Growth Defect
RIM11 YMR139W Protein kinase physical 1 1 1 Reconstituted Complex
MMS22 YLR320W Subunit of E3 ubiquitin ligase complex involved in replication repair physical 1 1 1 Affinity Capture-MS
SRV2 YNL138W CAP (cyclase-associated protein) genetic 1 1 1 Phenotypic Suppression
VPS21 YOR089C Endosomal Rab family GTPase physical 1 1 1 Affinity Capture-MS
STE7 YDL159W Signal transducing MAP kinase kinase genetic 1 1 1 Phenotypic Suppression
URE2 YNL229C Nitrogen catabolite repression transcriptional regulator physical 1 1 1 PCA
YDJ1 YNL064C Type I HSP40 co-chaperone physical 1 1 1 Reconstituted Complex
TIF4631 YGR162W Translation initiation factor eIF4G and scaffold protein physical 1 1 1 Affinity Capture-MS
TIF2 YJL138C Translation initiation factor eIF4A physical 1 1 1 Reconstituted Complex
YIG1 YPL201C Protein that interacts with glycerol 3-phosphatase physical 1 1 1 Reconstituted Complex
VAM6 YDL077C Guanine nucleotide exchange factor for the GTPase Gtr1p physical 1 1 1 Affinity Capture-MS
TEC1 YBR083W Transcription factor targeting filamentation genes and Ty1 expression genetic 1 1 1 Phenotypic Suppression
WHI3 YNL197C RNA binding protein that modulates mRNA stability genetic 1 1 1 Phenotypic Suppression
TPM1 YNL079C Major isoform of tropomyosin genetic 1 1 1 Phenotypic Suppression
WHI2 YOR043W Negative regulator of TORC1 in response to limiting leucine genetic 1 1 1 Synthetic Rescue
WSC3 YOL105C Sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway genetic 1 1 1 Dosage Rescue
VPS4 YPR173C AAA-ATPase involved in multivesicular body (MVB) protein sorting genetic 1 1 1 Synthetic Lethality
CLN3 YAL040C G1 cyclin involved in cell cycle progression genetic 1 1 1 Phenotypic Enhancement
EBS1 YDR206W Protein involved in translation inhibition and nonsense-mediated decay physical 1 1 1 Affinity Capture-MS
FAR3 YMR052W Protein of unknown function genetic 1 1 1 Synthetic Lethality
MSB2 YGR014W Mucin family member involved in various signaling pathways physical 1 1 1 PCA
MSB2 YGR014W Mucin family member involved in various signaling pathways genetic 1 1 1 Synthetic Rescue
BLI1 YKL061W Subunit of the BLOC-1 complex involved in endosomal maturation physical 1 1 1 Affinity Capture-MS
NST1 YNL091W Translational inhibitor and suppressor of proteasome-assembly defects physical 1 1 1 Affinity Capture-Western
CLB1 YGR108W B-type cyclin involved in cell cycle progression genetic 1 1 1 Phenotypic Enhancement
DOC1 YGL240W Processivity factor genetic 1 1 1 Synthetic Lethality
SKO1 YNL167C Basic leucine zipper transcription factor of the ATF/CREB family genetic 1 1 1 Phenotypic Suppression
PHO4 YFR034C Basic helix-loop-helix (bHLH) transcription factor of the myc-family physical 1 1 1 Affinity Capture-MS
SSC1 YJR045C Hsp70 family ATPase physical 1 1 1 Reconstituted Complex
PLC1 YPL268W Phospholipase C genetic 1 1 1 Dosage Rescue
MOT2 YER068W Ubiquitin-protein ligase subunit of the CCR4-NOT complex genetic 1 1 1 Phenotypic Suppression
CLB5 YPR120C B-type cyclin involved in DNA replication during S phase genetic 1 1 1 Phenotypic Enhancement
PEA2 YER149C Coiled-coil 12S polarisome subunit genetic 1 1 1 Phenotypic Suppression
BUD8 YLR353W Protein involved in bud-site selection genetic 1 1 1 Phenotypic Suppression
SSA3 YBL075C ATPase involved in protein folding and the response to stress physical 1 1 1 Affinity Capture-Western
AKR1 YDR264C Palmitoyl transferase involved in protein palmitoylation genetic 1 1 1 Synthetic Rescue
HKR1 YDR420W Mucin family member that functions as an osmosensor in the HOG pathway genetic 1 1 1 Synthetic Rescue
GPR1 YDL035C Plasma membrane G protein coupled receptor (GPCR) genetic 1 1 1 Dosage Rescue
SPA2 YLL021W Component of the polarisome physical 1 1 1 Two-hybrid
SPA2 YLL021W Component of the polarisome genetic 1 1 1 Phenotypic Suppression
CLA4 YNL298W Cdc42p-activated signal transducing kinase physical 1 1 1 Biochemical Activity
CLA4 YNL298W Cdc42p-activated signal transducing kinase genetic 1 1 1 Phenotypic Suppression
DFG5 YMR238W Putative mannosidase genetic 1 1 1 Phenotypic Suppression
RSR1 YGR152C Ras-type GTPase genetic 1 1 1 Phenotypic Enhancement
PMT4 YJR143C Protein O-mannosyltransferase genetic 1 1 1 Phenotypic Enhancement
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
MOG1 YJR074W Conserved nuclear protein that interacts with GTP-Gsp1p physical 1 1 1 Affinity Capture-MS
RPS0A YGR214W Ribosomal 40S subunit protein S0A genetic 1 1 1 Phenotypic Suppression
HLR1 YDR528W Protein involved in regulation of cell wall composition and integrity genetic 1 1 1 Dosage Rescue
IFH1 YLR223C Coactivator, regulates transcription of ribosomal protein (RP) genes physical 1 1 1 Affinity Capture-MS
OCH1 YGL038C Mannosyltransferase of the cis-Golgi apparatus genetic 1 1 1 Synthetic Lethality
PBP4 YDL053C Pbp1p binding protein physical 1 1 1 Affinity Capture-MS
AHK1 YDL073W Scaffold protein in the HKR1 sub-branch of the Hog1p-signaling pathway physical 1 1 1 Affinity Capture-Western
GRX4 YER174C Glutathione-dependent oxidoreductase and glutathione S-transferase physical 1 1 1 Reconstituted Complex
ANB1 YJR047C Translation elongation factor eIF-5A physical 1 1 1 Reconstituted Complex
RDS2 YPL133C Transcription factor involved in regulating gluconeogenesis physical 1 1 1 Reconstituted Complex
CMK2 YOL016C Calmodulin-dependent protein kinase physical 1 1 1 Biochemical Activity
CMK2 YOL016C Calmodulin-dependent protein kinase genetic 1 1 1 Phenotypic Suppression
FPS1 YLL043W Aquaglyceroporin, plasma membrane channel genetic 1 1 1 Dosage Rescue
PTK2 YJR059W Serine/threonine protein kinase physical 1 1 1 Biochemical Activity
PTK2 YJR059W Serine/threonine protein kinase genetic 1 1 1 Phenotypic Suppression
SSK22 YCR073C MAP kinase kinase kinase of HOG1 mitogen-activated signaling pathway genetic 1 1 1 Synthetic Lethality
DFG16 YOR030W Probable multiple transmembrane protein genetic 1 1 1 Phenotypic Suppression
DFG10 YIL049W Probable polyprenol reductase genetic 1 1 1 Phenotypic Suppression
AIM10 YER087W Protein with similarity to tRNA synthetases physical 1 1 1 Reconstituted Complex
LRE1 YCL051W Protein involved in control of cell wall structure and stress response genetic 1 1 1 Dosage Rescue
DBR1 YKL149C RNA lariat debranching enzyme genetic 1 1 1 Phenotypic Suppression