Standard name Systematic name Name description Description
GRX4 YER174C Glutathione-dependent oxidoreductase and glutathione S-transferase Glutathione-dependent oxidoreductase and glutathione S-transferase; hydroperoxide/superoxide-radical responsive monothiol glutaredoxin subfamily member with Grx3p and Grx5p; protects cells from oxidative damage with GRX3 and GRX5; with Grx3p, promotes dissociation of Aft1p from iron regulon gene promoters and subsequent nuclear export in iron-replete conditions, regulating iron homeostasis; involved with Grx3p in Sir2p deglutathionylation, restoring deacetylase activity after disulfide stress
Visualize the interactome of GRX4
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)
G1(P) 31

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.977 0.931 0.987
Mito NaN 0.069 NaN

GFP localization & abundance

GFP localization GFP abundance
cytoplasm, nucleus 7800

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
GRX4 1 0 0 0 0

Enzyme information

Catalyzed reactions in Yeast8
r_0481 (glutathione oxidoreductase)

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
GRX3 YDR098C Glutathione-dependent oxidoreductase genetic 11 4 8 Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Phenotypic Enhancement, Synthetic Rescue, Phenotypic Enhancement, Synthetic Growth Defect
BUD32 YGR262C Protein kinase physical 8 4 6 Affinity Capture-MS, Affinity Capture-Western, Two-hybrid, Affinity Capture-MS, Two-hybrid, Biochemical Activity, Affinity Capture-Western, Biochemical Activity
AFT1 YGL071W Transcription factor involved in iron utilization and homeostasis physical 7 3 4 Two-hybrid, Affinity Capture-Western, Two-hybrid, Reconstituted Complex, Affinity Capture-Western, Two-hybrid, Affinity Capture-Western
BOL2 YGL220W Cytosolic protein involved in repression of iron regulon transcription physical 3 3 3 Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex
GRX3 YDR098C Glutathione-dependent oxidoreductase physical 3 3 2 Two-hybrid, Reconstituted Complex, Affinity Capture-Western
SLT2 YHR030C Serine/threonine MAP kinase physical 3 2 1 Two-hybrid, Affinity Capture-Western, Affinity Capture-Western
YAP5 YIR018W Basic leucine zipper (bZIP) iron-sensing transcription factor regulation 2 2 2 DNA to cDNA expression microarray evidence, reverse transcription polymerase chain reaction evidence
CMK1 YFR014C Calmodulin-dependent protein kinase physical 2 2 2 Biochemical Activity, Reconstituted Complex
AFT1 YGL071W Transcription factor involved in iron utilization and homeostasis genetic 2 2 2 Phenotypic Suppression, Synthetic Rescue
GRX4 YER174C Glutathione-dependent oxidoreductase and glutathione S-transferase physical 2 2 2 Reconstituted Complex, Affinity Capture-Western
GIN4 YDR507C Protein kinase involved in bud growth and assembly of the septin ring genetic 2 1 2 Negative Genetic, Negative Genetic
HRQ1 YDR291W 3'-5' DNA helicase of the conserved RecQ family genetic 2 2 1 Negative Genetic, Positive Genetic
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 2 2 1 Negative Genetic, Positive Genetic
POP2 YNR052C Subunit of Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
YJR011C YJR011C Putative protein of unknown function genetic 2 1 1 Negative Genetic, Negative Genetic
SFP1 YLR403W Regulates transcription of ribosomal protein and biogenesis genes regulation 1 1 1 DNA to cDNA expression microarray evidence
UGA3 YDL170W Transcriptional activator for GABA-dependent induction of GABA genes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CBF5 YLR175W Pseudouridine synthase catalytic subunit of box H/ACA snoRNPs genetic 1 1 1 Negative Genetic
ESA1 YOR244W Catalytic subunit of the histone acetyltransferase complex (NuA4) physical 1 1 1 Biochemical Activity
BRX1 YOL077C Nucleolar protein genetic 1 1 1 Negative Genetic
ECM2 YBR065C Pre-mRNA splicing factor genetic 1 1 1 Negative Genetic
ACT1 YFL039C Actin, structural protein in cytoskeleton genetic 1 1 1 Synthetic Haploinsufficiency
ARP3 YJR065C Essential component of the Arp2/3 complex genetic 1 1 1 Negative Genetic
ELP2 YGR200C Subunit of Elongator complex genetic 1 1 1 Negative Genetic
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
ESF2 YNR054C Essential nucleolar protein involved in pre-18S rRNA processing genetic 1 1 1 Negative Genetic
BCK1 YJL095W MAPKKK acting in the protein kinase C signaling pathway genetic 1 1 1 Dosage Rescue
DRE2 YKR071C Component of the cytosolic Fe-S protein assembly (CIA) machinery genetic 1 1 1 Synthetic Growth Defect
FAR11 YNL127W Protein involved in recovery from cell cycle arrest genetic 1 1 1 Negative Genetic
FYV10 YIL097W Subunit of GID complex genetic 1 1 1 Negative Genetic
DUN1 YDL101C Cell-cycle checkpoint S/T protein kinase genetic 1 1 1 Phenotypic Suppression
CDC123 YLR215C Assembly factor for the eIF2 translation initiation factor complex genetic 1 1 1 Negative Genetic
ATP20 YPR020W Subunit g of the mitochondrial F1F0 ATP synthase genetic 1 1 1 Negative Genetic
BRE5 YNR051C Ubiquitin protease cofactor physical 1 1 1 Affinity Capture-MS
CBF1 YJR060W Basic helix-loop-helix (bHLH) protein genetic 1 1 1 Positive Genetic
GAL80 YML051W Transcriptional regulator involved in the repression of GAL genes genetic 1 1 1 Negative Genetic
BNR1 YIL159W Formin genetic 1 1 1 Negative Genetic
CPR7 YJR032W Peptidyl-prolyl cis-trans isomerase (cyclophilin) genetic 1 1 1 Negative Genetic
ERV14 YGL054C COPII-coated vesicle protein genetic 1 1 1 Negative Genetic
BAP3 YDR046C Amino acid permease genetic 1 1 1 Negative Genetic
BOL3 YAL046C Protein involved in Fe-S cluster transfer to mitochondrial clients physical 1 1 1 Two-hybrid
COQ11 YLR290C Putative oxidoreductase, subunit of Coenzyme Q biosynthetic complexes genetic 1 1 1 Negative Genetic
YRA1 YDR381W Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-MS
SAT4 YCR008W Ser/Thr protein kinase involved in salt tolerance, nutrient response physical 1 1 1 Reconstituted Complex
SCH9 YHR205W AGC family protein kinase physical 1 1 1 Reconstituted Complex
STE11 YLR362W Signal transducing MEK kinase physical 1 1 1 Reconstituted Complex
TPK1 YJL164C cAMP-dependent protein kinase catalytic subunit physical 1 1 1 Reconstituted Complex
YGK3 YOL128C Protein kinase related to mammalian GSK-3 glycogen synthase kinases physical 1 1 1 Reconstituted Complex
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
MPT5 YGL178W mRNA-binding protein of the PUF family physical 1 1 1 Affinity Capture-RNA
SIR2 YDL042C Conserved NAD+ dependent histone deacetylase of the Sirtuin family physical 1 1 1 Affinity Capture-Western
SLT2 YHR030C Serine/threonine MAP kinase genetic 1 1 1 Dosage Rescue
HSP82 YPL240C Hsp90 chaperone physical 1 1 1 Affinity Capture-MS
HSC82 YMR186W Cytoplasmic chaperone of the Hsp90 family physical 1 1 1 Affinity Capture-MS
GUA1 YMR217W GMP synthase physical 1 1 1 Two-hybrid
GUA1 YMR217W GMP synthase genetic 1 1 1 Dosage Rescue
YBR238C YBR238C Mitochondrial membrane protein genetic 1 1 1 Negative Genetic
SIP4 YJL089W C6 zinc cluster transcriptional activator genetic 1 1 1 Negative Genetic
YJR096W YJR096W Xylose and arabinose reductase genetic 1 1 1 Negative Genetic
MFA2 YNL145W Mating pheromone a-factor genetic 1 1 1 Negative Genetic
GRX5 YPL059W Glutathione-dependent oxidoreductase genetic 1 1 1 Synthetic Rescue
QCR10 YHR001W-A Subunit of the ubiqunol-cytochrome c oxidoreductase complex genetic 1 1 1 Positive Genetic
PFK1 YGR240C Alpha subunit of heterooctameric phosphofructokinase genetic 1 1 1 Positive Genetic
RNR4 YGR180C Ribonucleotide-diphosphate reductase (RNR) small subunit genetic 1 1 1 Synthetic Growth Defect
GSH1 YJL101C Gamma glutamylcysteine synthetase genetic 1 1 1 Phenotypic Suppression
SLM3 YDL033C tRNA-specific 2-thiouridylase genetic 1 1 1 Positive Genetic
TFC3 YAL001C Subunit of RNA polymerase III transcription initiation factor complex genetic 1 1 1 Negative Genetic
TAF5 YBR198C Subunit (90 kDa) of TFIID and SAGA complexes genetic 1 1 1 Negative Genetic
USE1 YGL098W Essential SNARE protein localized to the ER genetic 1 1 1 Negative Genetic
MED6 YHR058C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
RRP4 YHR069C Exosome non-catalytic core component genetic 1 1 1 Negative Genetic
MRPL11 YDL202W Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
HPC2 YBR215W Subunit of the HIR complex genetic 1 1 1 Negative Genetic
YCR090C YCR090C Putative protein of unknown function genetic 1 1 1 Negative Genetic
NHP10 YDL002C Non-essential INO80 chromatin remodeling complex subunit genetic 1 1 1 Negative Genetic
OCA6 YDR067C Cytoplasmic protein required for replication of Brome mosaic virus genetic 1 1 1 Negative Genetic
RPA14 YDR156W RNA polymerase I subunit A14 genetic 1 1 1 Negative Genetic
SAC3 YDR159W mRNA export factor genetic 1 1 1 Negative Genetic
PES4 YFR023W Poly(A) binding protein, suppressor of DNA polymerase epsilon mutation genetic 1 1 1 Negative Genetic
MRP13 YGR084C Mitochondrial ribosomal protein of the small subunit genetic 1 1 1 Negative Genetic
NEL1 YHR035W Activator of Sar1p GTPase activity genetic 1 1 1 Negative Genetic
SMF2 YHR050W Divalent metal ion transporter involved in manganese homeostasis genetic 1 1 1 Negative Genetic
SSF1 YHR066W Constituent of 66S pre-ribosomal particles genetic 1 1 1 Negative Genetic
SMN1 YHR202W Putative AMP hydrolase genetic 1 1 1 Negative Genetic
NIT1 YIL164C Nitrilase genetic 1 1 1 Negative Genetic
JJJ3 YJR097W Iron-binding protein genetic 1 1 1 Negative Genetic
KTR2 YKR061W Mannosyltransferase involved in N-linked protein glycosylation genetic 1 1 1 Negative Genetic
RTT109 YLL002W Histone acetyltransferase genetic 1 1 1 Negative Genetic
YKE2 YLR200W Subunit of the heterohexameric Gim/prefoldin protein complex genetic 1 1 1 Negative Genetic
RAD52 YML032C Protein involved in homologous recombination genetic 1 1 1 Negative Genetic
MRE11 YMR224C Nuclease subunit of the MRX complex with Rad50p and Xrs2p genetic 1 1 1 Negative Genetic
MSO1 YNR049C Lipid-interacting protein in SNARE complex assembly machinery genetic 1 1 1 Negative Genetic
IZH2 YOL002C Plasma membrane receptor for plant antifungal osmotin genetic 1 1 1 Negative Genetic
YOL024W YOL024W Putative protein of unknown function genetic 1 1 1 Negative Genetic
RPP2A YOL039W Ribosomal protein P2 alpha genetic 1 1 1 Negative Genetic
GSH2 YOL049W Glutathione synthetase genetic 1 1 1 Negative Genetic
HIR2 YOR038C Subunit of HIR nucleosome assembly complex genetic 1 1 1 Negative Genetic
TMC1 YOR052C AN1-type zinc finger protein, effector of proteotoxic stress response genetic 1 1 1 Negative Genetic
RMI1 YPL024W Subunit of the RecQ (Sgs1p) - Topo III (Top3p) complex genetic 1 1 1 Negative Genetic
YME1 YPR024W Catalytic subunit of i-AAA protease complex genetic 1 1 1 Negative Genetic
KAR3 YPR141C Minus-end-directed microtubule motor genetic 1 1 1 Negative Genetic
ROF1 YHR177W Putative transcription factor containing a WOPR domain genetic 1 1 1 Negative Genetic
TRK1 YJL129C Component of the Trk1p-Trk2p potassium transport system genetic 1 1 1 Negative Genetic
RSO55 YLR281C Mitochondrial protein of unknown function genetic 1 1 1 Negative Genetic
TRM12 YML005W S-adenosylmethionine-dependent methyltransferase genetic 1 1 1 Negative Genetic
RPL18B YNL301C Ribosomal 60S subunit protein L18B genetic 1 1 1 Negative Genetic
SIA1 YOR137C Protein of unassigned function genetic 1 1 1 Negative Genetic
MDM32 YOR147W Mitochondrial inner membrane protein with similarity to Mdm31p genetic 1 1 1 Negative Genetic
YOR381W-A YOR381W-A Putative protein of unknown function genetic 1 1 1 Negative Genetic
VMA11 YPL234C Vacuolar ATPase V0 domain subunit c' genetic 1 1 1 Negative Genetic
CGI121 YML036W Component of the EKC/KEOPS complex physical 1 1 1 Affinity Capture-MS
CMK2 YOL016C Calmodulin-dependent protein kinase physical 1 1 1 Reconstituted Complex
CGR1 YGL029W Protein involved in nucleolar integrity and processing of pre-rRNA genetic 1 1 1 Negative Genetic
GPI13 YLL031C ER membrane localized phosphoryltransferase genetic 1 1 1 Positive Genetic
BOL1 YAL044W-A Mitochondrial matrix protein involved in Fe-S cluster biogenesis physical 1 1 1 Two-hybrid
ATG15 YCR068W Phospholipase genetic 1 1 1 Negative Genetic
DFG10 YIL049W Probable polyprenol reductase genetic 1 1 1 Negative Genetic
DPI8 YJL133C-A Putative mitochondrial protein of unknown function genetic 1 1 1 Positive Genetic
ALG8 YOR067C Glucosyl transferase genetic 1 1 1 Negative Genetic