Standard name Systematic name Name description Description
CMK2 YOL016C Calmodulin-dependent protein kinase Calmodulin-dependent protein kinase; negative feedback controller of calcium/calcineurin signalling pathway, also has additional Crz1-independent role in promoting calcium tolerance; amino acid sequence similar to mammalian Cam Kinase II; CMK2 has a paralog, CMK1, that arose from the whole genome duplication
Visualize the interactome of CMK2
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)
M 148

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.977 0.987 0.970
Cell Periphery NaN NaN 0.056

GFP localization & abundance

GFP localization GFP abundance
cytoplasm 7500

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
CMK2 1 0 0 0 0

Enzyme information

Catalyzed reactions in Yeast8

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
CNB1 YKL190W Calcineurin B genetic 4 3 3 Synthetic Growth Defect, Synthetic Rescue, Phenotypic Enhancement, Synthetic Growth Defect
CMD1 YBR109C Calmodulin physical 3 2 3 Affinity Capture-MS, Reconstituted Complex, Affinity Capture-MS
FKH1 YIL131C Forkhead family transcription factor regulation 2 2 2 chromatin immunoprecipitation-chip evidence, ChEC-Seq experiments
GIS2 YNL255C Translational activator for mRNAs with internal ribosome entry sites physical 2 2 2 Affinity Capture-MS, Affinity Capture-RNA
SFP1 YLR403W Regulates transcription of ribosomal protein and biogenesis genes regulation 2 1 2 DNA to cDNA expression microarray evidence, DNA to cDNA expression microarray evidence
CIN5 YOR028C Basic leucine zipper (bZIP) transcription factor of the yAP-1 family genetic 2 1 2 Negative Genetic, Negative Genetic
CET1 YPL228W RNA 5'-triphosphatase involved in mRNA 5' capping genetic 2 1 2 Negative Genetic, Negative Genetic
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 2 1 2 Affinity Capture-RNA, Affinity Capture-RNA
CRZ1 YNL027W Transcription factor, activates transcription of stress response genes genetic 2 2 1 Synthetic Rescue, Phenotypic Suppression
RIM101 YHL027W Cys2His2 zinc-finger transcriptional repressor regulation 1 1 1 DNA to cDNA expression microarray evidence
SUM1 YDR310C Transcriptional repressor that regulates middle-sporulation genes regulation 1 1 1 DNA to cDNA expression microarray evidence
RFX1 YLR176C Major transcriptional repressor of DNA-damage-regulated genes regulation 1 1 1 DNA to cDNA expression microarray evidence
SPT10 YJL127C Histone H3 acetylase with a role in transcriptional regulation regulation 1 1 1 DNA to cDNA expression microarray evidence
AFT2 YPL202C Iron-regulated transcriptional activator regulation 1 1 1 DNA to cDNA expression microarray evidence
CBF1 YJR060W Basic helix-loop-helix (bHLH) protein regulation 1 1 1 DNA to cDNA expression microarray evidence
FKH2 YNL068C Forkhead family transcription factor regulation 1 1 1 ChEC-Seq experiments
GCR2 YNL199C Transcriptional activator of genes involved in glycolysis regulation 1 1 1 DNA to cDNA expression microarray evidence
HFI1 YPL254W Adaptor protein required for structural integrity of the SAGA complex regulation 1 1 1 DNA to cDNA expression microarray evidence
MSN2 YMR037C Stress-responsive transcriptional activator regulation 1 1 1 DNA to cDNA expression microarray evidence
RPN4 YDL020C Transcription factor that stimulates expression of proteasome genes regulation 1 1 1 DNA to cDNA expression microarray evidence
STP1 YDR463W Transcription factor regulation 1 1 1 DNA to cDNA expression microarray evidence
SUA7 YPR086W Transcription factor TFIIB regulation 1 1 1 chromatin immunoprecipitation-chip evidence
NRG1 YDR043C Transcriptional repressor regulation 1 1 1 DNA to cDNA expression microarray evidence
RSF2 YJR127C Zinc-finger protein regulation 1 1 1 DNA to cDNA expression microarray evidence
SIP4 YJL089W C6 zinc cluster transcriptional activator regulation 1 1 1 DNA to cDNA expression microarray evidence
SWI4 YER111C DNA binding component of the SBF complex (Swi4p-Swi6p) regulation 1 1 1 DNA to cDNA expression microarray evidence
CST6 YIL036W Basic leucine zipper (bZIP) transcription factor from ATF/CREB family regulation 1 1 1 DNA to cDNA expression microarray evidence
TUP1 YCR084C General repressor of transcription in complex with Cyc8p regulation 1 1 1 DNA to cDNA expression microarray evidence
PPR1 YLR014C Zinc finger transcription factor regulation 1 1 1 DNA to cDNA expression microarray evidence
SIN3 YOL004W Component of both the Rpd3S and Rpd3L histone deacetylase complexes regulation 1 1 1 DNA to cDNA expression microarray evidence
PHO4 YFR034C Basic helix-loop-helix (bHLH) transcription factor of the myc-family regulation 1 1 1 DNA to cDNA expression microarray evidence
UGA3 YDL170W Transcriptional activator for GABA-dependent induction of GABA genes regulation 1 1 1 DNA to cDNA expression microarray evidence
ROX1 YPR065W Heme-dependent repressor of hypoxic genes regulation 1 1 1 DNA to cDNA expression microarray evidence
RGM1 YMR182C Putative zinc finger DNA binding transcription factor regulation 1 1 1 DNA to cDNA expression microarray evidence
RTG3 YBL103C bHLH/Zip transcription factor for retrograde (RTG) and TOR pathways regulation 1 1 1 DNA to cDNA expression microarray evidence
CAD1 YDR423C AP-1-like basic leucine zipper (bZIP) transcriptional activator regulation 1 1 1 DNA to cDNA expression microarray evidence
CRZ1 YNL027W Transcription factor, activates transcription of stress response genes regulation 1 1 1 DNA to cDNA expression microarray evidence
AFT1 YGL071W Transcription factor involved in iron utilization and homeostasis regulation 1 1 1 DNA to cDNA expression microarray evidence
DAL82 YNL314W Positive regulator of allophanate inducible genes regulation 1 1 1 DNA to cDNA expression microarray evidence
RPH1 YER169W JmjC domain-containing histone demethylase regulation 1 1 1 DNA to cDNA expression microarray evidence
SMP1 YBR182C MADS-box transcription factor involved in osmotic stress response regulation 1 1 1 DNA to cDNA expression microarray evidence
OAF1 YAL051W Oleate-activated transcription factor regulation 1 1 1 DNA to cDNA expression microarray evidence
DAL81 YIR023W Positive regulator of genes in multiple nitrogen degradation pathways regulation 1 1 1 DNA to cDNA expression microarray evidence
ADR1 YDR216W Carbon source-responsive zinc-finger transcription factor regulation 1 1 1 DNA to cDNA expression microarray evidence
CUP2 YGL166W Copper-binding transcription factor regulation 1 1 1 DNA to cDNA expression microarray evidence
FLO8 YER109C Transcription factor regulation 1 1 1 DNA to cDNA expression microarray evidence
HAA1 YPR008W Transcriptional activator involved in adaptation to weak acid stress regulation 1 1 1 DNA to cDNA expression microarray evidence
HIR2 YOR038C Subunit of HIR nucleosome assembly complex regulation 1 1 1 DNA to cDNA expression microarray evidence
SIP3 YNL257C Putative sterol transfer protein regulation 1 1 1 DNA to cDNA expression microarray evidence
UME1 YPL139C Component of both the Rpd3S and Rpd3L histone deacetylase complexes regulation 1 1 1 DNA to cDNA expression microarray evidence
CKA1 YIL035C Alpha catalytic subunit of casein kinase 2 (CK2) physical 1 1 1 Biochemical Activity
ARL1 YBR164C Soluble GTPase with a role in regulation of membrane traffic genetic 1 1 1 Negative Genetic
CBC2 YPL178W Small subunit of the heterodimeric cap binding complex with Sto1p genetic 1 1 1 Negative Genetic
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
APC1 YNL172W Largest subunit of the Anaphase-Promoting Complex/Cyclosome genetic 1 1 1 Negative Genetic
ARC18 YLR370C Subunit of the ARP2/3 complex physical 1 1 1 Reconstituted Complex
CCT4 YDL143W Subunit of the cytosolic chaperonin Cct ring complex physical 1 1 1 Reconstituted Complex
ATG29 YPL166W Autophagy-specific protein physical 1 1 1 Reconstituted Complex
CMK1 YFR014C Calmodulin-dependent protein kinase genetic 1 1 1 Synthetic Rescue
CLN1 YMR199W G1 cyclin involved in regulation of the cell cycle genetic 1 1 1 Negative Genetic
AHC1 YOR023C Subunit of the Ada histone acetyltransferase complex genetic 1 1 1 Negative Genetic
AIM4 YBR194W Protein proposed to be associated with the nuclear pore complex physical 1 1 1 Affinity Capture-MS
BRE5 YNR051C Ubiquitin protease cofactor genetic 1 1 1 Negative Genetic
BUB1 YGR188C Protein kinase involved in the cell cycle checkpoint into anaphase genetic 1 1 1 Negative Genetic
AKR1 YDR264C Palmitoyl transferase involved in protein palmitoylation physical 1 1 1 Biochemical Activity
AVT6 YER119C Vacuolar aspartate and glutamate exporter physical 1 1 1 Reconstituted Complex
CBS1 YDL069C Mitochondrial translational activator of the COB mRNA genetic 1 1 1 Positive Genetic
CDA1 YLR307W Chitin deacetylase physical 1 1 1 Reconstituted Complex
YML037C YML037C Putative protein of unknown function physical 1 1 1 Biochemical Activity
VHR2 YER064C Non-essential nuclear protein physical 1 1 1 Biochemical Activity
CMR3 YPR013C Putative zinc finger protein physical 1 1 1 Biochemical Activity
YML096W YML096W Putative protein with similarity to asparagine synthetases physical 1 1 1 Biochemical Activity
PAH1 YMR165C Mg2+-dependent phosphatidate (PA) phosphatase physical 1 1 1 Biochemical Activity
NSR1 YGR159C Nucleolin, nucleolar protein that binds nuclear localization sequences physical 1 1 1 Biochemical Activity
FUS3 YBL016W Mitogen-activated serine/threonine protein kinase involved in mating physical 1 1 1 Biochemical Activity
KNS1 YLL019C Protein kinase involved in negative regulation of PolIII transcription physical 1 1 1 Biochemical Activity
PBS2 YJL128C MAP kinase kinase of the HOG signaling pathway physical 1 1 1 Biochemical Activity
PHO85 YPL031C Cyclin-dependent kinase physical 1 1 1 Biochemical Activity
PKH2 YOL100W Serine/threonine protein kinase physical 1 1 1 Biochemical Activity
STE11 YLR362W Signal transducing MEK kinase physical 1 1 1 Biochemical Activity
STE11 YLR362W Signal transducing MEK kinase genetic 1 1 1 Phenotypic Suppression
TPK2 YPL203W cAMP-dependent protein kinase catalytic subunit physical 1 1 1 Biochemical Activity
TPK3 YKL166C cAMP-dependent protein kinase catalytic subunit physical 1 1 1 Biochemical Activity
PKP2 YGL059W Mitochondrial protein kinase physical 1 1 1 Biochemical Activity
YGK3 YOL128C Protein kinase related to mammalian GSK-3 glycogen synthase kinases physical 1 1 1 Biochemical Activity
HSF1 YGL073W Trimeric heat shock transcription factor physical 1 1 1 Biochemical Activity
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-RNA
RPN11 YFR004W Metalloprotease subunit of 19S regulatory particle physical 1 1 1 Affinity Capture-MS
EDE1 YBL047C Scaffold protein involved in the formation of early endocytic sites physical 1 1 1 Affinity Capture-MS
EDE1 YBL047C Scaffold protein involved in the formation of early endocytic sites genetic 1 1 1 Dosage Rescue
SYP1 YCR030C Negative regulator of WASP-Arp23 complex physical 1 1 1 Affinity Capture-MS
URN1 YPR152C Protein of unknown function containing WW and FF domains physical 1 1 1 Affinity Capture-MS
DBR1 YKL149C RNA lariat debranching enzyme physical 1 1 1 Reconstituted Complex
DSE3 YOR264W Daughter cell-specific protein, may help establish daughter fate physical 1 1 1 Reconstituted Complex
ERS1 YCR075C Protein involved in cystine transport physical 1 1 1 Reconstituted Complex
GRE3 YHR104W Aldose reductase physical 1 1 1 Reconstituted Complex
GRX4 YER174C Glutathione-dependent oxidoreductase and glutathione S-transferase physical 1 1 1 Reconstituted Complex
JIP5 YPR169W Protein required for biogenesis of the large ribosomal subunit physical 1 1 1 Reconstituted Complex
LSM1 YJL124C Lsm (Like Sm) protein physical 1 1 1 Reconstituted Complex
MAG1 YER142C 3-methyl-adenine DNA glycosylase physical 1 1 1 Reconstituted Complex
MRC1 YCL061C S-phase checkpoint protein required for DNA replication physical 1 1 1 Reconstituted Complex
MRP49 YKL167C Mitochondrial ribosomal protein of the large subunit physical 1 1 1 Reconstituted Complex
MRP8 YKL142W Protein of unknown function physical 1 1 1 Reconstituted Complex
MSN5 YDR335W Karyopherin physical 1 1 1 Reconstituted Complex
NET1 YJL076W Core subunit of the RENT complex physical 1 1 1 Reconstituted Complex
NUP53 YMR153W FG-nucleoporin component of central core of nuclear pore complex (NPC) physical 1 1 1 Reconstituted Complex
OPY1 YBR129C Protein of unknown function physical 1 1 1 Reconstituted Complex
OXA1 YER154W Mitochondrial inner membrane insertase physical 1 1 1 Reconstituted Complex
PIR1 YKL164C O-glycosylated protein required for cell wall stability physical 1 1 1 Reconstituted Complex
PSY2 YNL201C Subunit of protein phosphatase PP4 complex physical 1 1 1 Reconstituted Complex
RAD2 YGR258C Single-stranded DNA endonuclease physical 1 1 1 Reconstituted Complex
RFC5 YBR087W Subunit of heteropentameric Replication factor C (RF-C) physical 1 1 1 Reconstituted Complex
GPP1 YIL053W Constitutively expressed DL-glycerol-3-phosphate phosphatase physical 1 1 1 Reconstituted Complex
RIM13 YMR154C Calpain-like cysteine protease physical 1 1 1 Reconstituted Complex
RPL17B YJL177W Ribosomal 60S subunit protein L17B physical 1 1 1 Reconstituted Complex
RPO26 YPR187W RNA polymerase subunit ABC23 physical 1 1 1 Reconstituted Complex
SDL1 YIL167W Blocked reading frame otherwise encoding L-serine dehydratase physical 1 1 1 Reconstituted Complex
SGT1 YOR057W Cochaperone protein physical 1 1 1 Reconstituted Complex
SOD2 YHR008C Mitochondrial manganese superoxide dismutase physical 1 1 1 Reconstituted Complex
SPP1 YPL138C Subunit of COMPASS (Set1C) physical 1 1 1 Reconstituted Complex
SYF1 YDR416W Member of the NineTeen Complex (NTC) physical 1 1 1 Reconstituted Complex
TUB4 YLR212C Gamma-tubulin physical 1 1 1 Reconstituted Complex
TVP18 YMR071C Integral membrane protein physical 1 1 1 Reconstituted Complex
VMA13 YPR036W Subunit H of the V1 peripheral membrane domain of V-ATPase physical 1 1 1 Reconstituted Complex
YBR071W YBR071W Protein of unknown function found in the cytoplasm and bud neck physical 1 1 1 Reconstituted Complex
YBR220C YBR220C Putative protein of unknown function physical 1 1 1 Reconstituted Complex
VFA1 YER128W Protein that interacts with Vps4p and has a role in vacuolar sorting physical 1 1 1 Reconstituted Complex
TDA10 YGR205W ATP-binding protein of unknown function physical 1 1 1 Reconstituted Complex
RTC3 YHR087W Protein of unknown function involved in RNA metabolism physical 1 1 1 Affinity Capture-MS
SBP1 YHL034C Protein that binds eIF4G and has a role in repression of translation physical 1 1 1 Affinity Capture-RNA
PUF3 YLL013C Protein of the mitochondrial outer surface physical 1 1 1 Affinity Capture-RNA
CRM1 YGR218W Nuclear export factor, exportin physical 1 1 1 Affinity Capture-MS
PUF2 YPR042C PUF family mRNA-binding protein physical 1 1 1 Affinity Capture-RNA
POL2 YNL262W Catalytic subunit of DNA polymerase (II) epsilon physical 1 1 1 Biochemical Activity
HSP82 YPL240C Hsp90 chaperone physical 1 1 1 Affinity Capture-MS
HSC82 YMR186W Cytoplasmic chaperone of the Hsp90 family physical 1 1 1 Affinity Capture-MS
SSD1 YDR293C Translational repressor physical 1 1 1 Affinity Capture-RNA
OCA1 YNL099C Putative protein tyrosine phosphatase genetic 1 1 1 Positive Genetic
SLT2 YHR030C Serine/threonine MAP kinase genetic 1 1 1 Positive Genetic
TPS2 YDR074W Phosphatase subunit of the trehalose-6-P synthase/phosphatase complex genetic 1 1 1 Negative Genetic
DBF2 YGR092W Ser/Thr kinase involved in transcription and stress response genetic 1 1 1 Negative Genetic
PFK1 YGR240C Alpha subunit of heterooctameric phosphofructokinase genetic 1 1 1 Negative Genetic
DSS1 YMR287C 3'-5' exoribonuclease genetic 1 1 1 Negative Genetic
STB1 YNL309W Protein with role in regulation of MBF-specific transcription at Start genetic 1 1 1 Negative Genetic
THI6 YPL214C Thiamine-phosphate diphosphorylase and hydroxyethylthiazole kinase genetic 1 1 1 Positive Genetic
KIN4 YOR233W Serine/threonine protein kinase genetic 1 1 1 Positive Genetic
PDI1 YCL043C Protein disulfide isomerase genetic 1 1 1 Synthetic Lethality
UBC7 YMR022W Ubiquitin conjugating enzyme genetic 1 1 1 Negative Genetic
RAS2 YNL098C GTP-binding protein genetic 1 1 1 Negative Genetic
VCX1 YDL128W Vacuolar membrane antiporter with Ca2+/H+ and K+/H+ exchange activity genetic 1 1 1 Synthetic Growth Defect
RCN1 YKL159C Protein involved in calcineurin regulation during calcium signaling genetic 1 1 1 Synthetic Growth Defect
RPD3 YNL330C Histone deacetylase, component of both the Rpd3S and Rpd3L complexes genetic 1 1 1 Negative Genetic
TPK1 YJL164C cAMP-dependent protein kinase catalytic subunit genetic 1 1 1 Negative Genetic
HMS1 YOR032C bHLH protein with similarity to myc-family transcription factors genetic 1 1 1 Negative Genetic
HST3 YOR025W Sirtuin, histone H3 deacetylase genetic 1 1 1 Negative Genetic
CTK3 YML112W Gamma subunit of C-terminal domain kinase I genetic 1 1 1 Positive Genetic
TEL1 YBL088C Protein kinase primarily involved in telomere length regulation genetic 1 1 1 Positive Genetic
RSC2 YLR357W Component of the RSC chromatin remodeling complex genetic 1 1 1 Negative Genetic
TAF1 YGR274C TFIID subunit, involved in RNA pol II transcription initiation genetic 1 1 1 Synthetic Lethality
COG3 YER157W Essential component of the conserved oligomeric Golgi complex genetic 1 1 1 Positive Genetic
PRP24 YMR268C Splicing factor that reanneals snRNPs during spliceosome recycling genetic 1 1 1 Positive Genetic
YCP4 YCR004C Protein of unknown function genetic 1 1 1 Positive Genetic
SEH1 YGL100W Subunit of the Nup84 nuclear pore and SEACAT subcomplexes genetic 1 1 1 Positive Genetic
SEC28 YIL076W Epsilon-COP subunit of the coatomer genetic 1 1 1 Positive Genetic
MNS1 YJR131W Alpha-1,2-mannosidase genetic 1 1 1 Positive Genetic
SLA2 YNL243W Adaptor protein that links actin to clathrin and endocytosis genetic 1 1 1 Positive Genetic
MOB2 YFL034C-B Activator of Cbk1p kinase genetic 1 1 1 Negative Genetic
CWC25 YNL245C Splicing factor required for the first step of pre-mRNA splicing genetic 1 1 1 Negative Genetic
TIM23 YNR017W Essential component of the TIM23 complex genetic 1 1 1 Negative Genetic
SEC12 YNR026C Guanine nucleotide exchange factor (GEF) genetic 1 1 1 Negative Genetic
RAD53 YPL153C DNA damage response kinase genetic 1 1 1 Negative Genetic
PRE7 YBL041W Beta 6 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
GPI10 YGL142C Integral membrane protein involved in GPI anchor synthesis genetic 1 1 1 Negative Genetic
SMD1 YGR074W Core Sm protein Sm D1 genetic 1 1 1 Negative Genetic
MED6 YHR058C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
SPC97 YHR172W Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex genetic 1 1 1 Negative Genetic
RAM2 YKL019W Alpha subunit of farnesyltransferase and geranylgeranyltransferase-I genetic 1 1 1 Negative Genetic
GPI12 YMR281W ER membrane protein involved in the second step of GPI anchor assembly genetic 1 1 1 Negative Genetic
DBP6 YNR038W Essential protein involved in ribosome biogenesis genetic 1 1 1 Negative Genetic
TBF1 YPL128C Telobox-containing general regulatory factor genetic 1 1 1 Negative Genetic
MRP10 YDL045W-A Mitochondrial ribosomal protein of the small subunit genetic 1 1 1 Negative Genetic
DPL1 YDR294C Dihydrosphingosine phosphate lyase genetic 1 1 1 Negative Genetic
SUL2 YLR092W High affinity sulfate permease genetic 1 1 1 Negative Genetic
MRPL17 YNL252C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
RPL19B YBL027W Ribosomal 60S subunit protein L19B genetic 1 1 1 Negative Genetic
PHB2 YGR231C Subunit of the prohibitin complex (Phb1p-Phb2p) genetic 1 1 1 Negative Genetic
SNF6 YHL025W Subunit of the SWI/SNF chromatin remodeling complex genetic 1 1 1 Negative Genetic
VPS53 YJL029C Component of the GARP (Golgi-associated retrograde protein) complex genetic 1 1 1 Negative Genetic
KCH1 YJR054W Potassium transporter that mediates K+ influx genetic 1 1 1 Negative Genetic
RPL22A YLR061W Ribosomal 60S subunit protein L22A genetic 1 1 1 Negative Genetic
DBP5 YOR046C Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family genetic 1 1 1 Synthetic Growth Defect
HRQ1 YDR291W 3'-5' DNA helicase of the conserved RecQ family genetic 1 1 1 Negative Genetic
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 1 1 1 Negative Genetic
CMC2 YBL059C-A Protein involved in respiratory chain complex assembly or maintenance genetic 1 1 1 Negative Genetic