Standard name Systematic name Name description Description
HST3 YOR025W Sirtuin, histone H3 deacetylase Sirtuin, histone H3 deacetylase; involved along with Hst4p in telomeric silencing, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism; member of the Sir2 family of NAD(+)-dependent protein deacetylases
Visualize the interactome of HST3
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)
M 172

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.971 0.979 0.906
Cell Periphery NaN NaN 0.078
ER NaN NaN 0.053

GFP localization & abundance

GFP localization GFP abundance
nucleus 319

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
HST3 6 0 0 0 0

Enzyme information

Catalyzed reactions in Yeast8
r_0767 (NAD nucleosidase nuclear)

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
HST4 YDR191W NAD(+)-dependent protein deacetylase genetic 24 4 16 Synthetic Lethality, Phenotypic Enhancement, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement, Negative Genetic, Negative Genetic, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Enhancement, Negative Genetic, Negative Genetic, Phenotypic Enhancement
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 13 4 9 Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Rescue, Phenotypic Enhancement, Negative Genetic, Negative Genetic, Negative Genetic
MRC1 YCL061C S-phase checkpoint protein required for DNA replication genetic 11 3 7 Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Lethality
RAD27 YKL113C 5' to 3' exonuclease, 5' flap endonuclease genetic 11 3 6 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic
POL32 YJR043C Third subunit of DNA polymerase delta genetic 9 2 6 Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic
CSM3 YMR048W Replication fork associated factor genetic 8 2 5 Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic
TOF1 YNL273W Subunit of a replication-pausing checkpoint complex genetic 7 3 6 Negative Genetic, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Synthetic Lethality, Negative Genetic, Negative Genetic
SRS2 YJL092W DNA helicase and DNA-dependent ATPase genetic 7 3 6 Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect
SWC4 YGR002C Component of the Swr1p complex that incorporates Htz1p into chromatin genetic 7 2 3 Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic
CDC45 YLR103C DNA replication initiation factor genetic 6 4 5 Negative Genetic, Synthetic Growth Defect, Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Rescue
CIK1 YMR198W Kinesin-associated protein genetic 6 3 5 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic
UBP8 YMR223W Ubiquitin-specific protease component of the SAGA acetylation complex genetic 6 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
ARP4 YJL081C Nuclear actin-related protein involved in chromatin remodeling genetic 6 2 3 Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
DIA2 YOR080W Origin-binding F-box protein genetic 6 2 3 Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality
SIC1 YLR079W Cyclin-dependent kinase inhibitor (CKI) genetic 6 2 3 Negative Genetic, Negative Genetic, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic
RAD9 YDR217C DNA damage-dependent checkpoint protein genetic 5 3 5 Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Synthetic Rescue, Synthetic Rescue
SLX4 YLR135W Endonuclease involved in processing DNA genetic 5 3 4 Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Synthetic Lethality
DPB3 YBR278W Third-largest subunit of DNA polymerase II (DNA polymerase epsilon) genetic 5 2 4 Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic
PPH3 YDR075W Catalytic subunit of protein phosphatase PP4 complex genetic 5 2 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Lethality
HSL1 YKL101W Nim1p-related protein kinase genetic 5 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SAE2 YGL175C Endonuclease required for telomere elongation genetic 5 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SGF11 YPL047W Integral subunit of SAGA histone acetyltransferase complex genetic 5 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
YNG2 YHR090C Subunit of NuA4, an essential histone acetyltransferase complex genetic 5 2 2 Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
FKH2 YNL068C Forkhead family transcription factor regulation 4 3 4 chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation- exonuclease evidence, ChEC-Seq experiments
CTF4 YPR135W Chromatin-associated protein genetic 4 2 4 Synthetic Rescue, Synthetic Rescue, Positive Genetic, Synthetic Rescue
RTT109 YLL002W Histone acetyltransferase genetic 4 2 4 Synthetic Rescue, Phenotypic Suppression, Synthetic Rescue, Phenotypic Suppression
RTT101 YJL047C Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex genetic 4 2 4 Synthetic Rescue, Phenotypic Suppression, Phenotypic Suppression, Synthetic Rescue
POL2 YNL262W Catalytic subunit of DNA polymerase (II) epsilon genetic 4 4 3 Synthetic Growth Defect, Synthetic Lethality, Phenotypic Enhancement, Negative Genetic
SPT21 YMR179W Protein with a role in transcriptional silencing genetic 4 3 3 Negative Genetic, Synthetic Rescue, Phenotypic Suppression, Negative Genetic
RTT107 YHR154W BRCA1 C-terminal domain protein needed for recovery from DNA damage genetic 4 3 3 Synthetic Rescue, Positive Genetic, Phenotypic Suppression, Synthetic Rescue
CDC6 YJL194W Essential ATP-binding protein required for DNA replication genetic 4 2 3 Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic
ORC2 YBR060C Subunit of the origin recognition complex (ORC) genetic 4 2 3 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic
POL3 YDL102W Catalytic subunit of DNA polymerase delta genetic 4 2 3 Negative Genetic, Phenotypic Enhancement, Negative Genetic, Negative Genetic
FKH2 YNL068C Forkhead family transcription factor genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
TAF6 YGL112C Subunit (60 kDa) of TFIID and SAGA complexes genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SGF73 YGL066W Subunit of DUBm module of SAGA and SLIK genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
VIP1 YLR410W Bifunctional inositol pyrophosphate kinase and phosphatase genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
ESA1 YOR244W Catalytic subunit of the histone acetyltransferase complex (NuA4) genetic 4 1 1 Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect
EAF1 YDR359C Component of the NuA4 histone acetyltransferase complex genetic 4 1 1 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality
EPL1 YFL024C Subunit of NuA4, an essential histone H4/H2A acetyltransferase complex genetic 4 1 1 Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect
CDC4 YFL009W F-box protein required for both the G1/S and G2/M phase transitions physical 3 3 3 Affinity Capture-MS, Biochemical Activity, Affinity Capture-Western
CTF18 YMR078C Subunit of a complex with Ctf8p genetic 3 2 3 Synthetic Rescue, Phenotypic Suppression, Synthetic Rescue
MMS22 YLR320W Subunit of E3 ubiquitin ligase complex involved in replication repair genetic 3 2 3 Synthetic Rescue, Phenotypic Suppression, Synthetic Rescue
MEC1 YBR136W Genome integrity checkpoint protein and PI kinase superfamily member genetic 3 2 3 Synthetic Lethality, Negative Genetic, Synthetic Lethality
CHD1 YER164W Chromatin remodeler that regulates various aspects of transcription genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
TAF9 YMR236W Subunit (17 kDa) of TFIID and SAGA complexes genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
SUS1 YBR111W-A Global transcriptional regulator, component of SAGA, TREX-2 complexes genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
MRE11 YMR224C Nuclease subunit of the MRX complex with Rad50p and Xrs2p genetic 3 2 2 Negative Genetic, Negative Genetic, Synthetic Lethality
DBF4 YDR052C Regulatory subunit of Cdc7p-Dbf4p kinase complex genetic 3 2 2 Negative Genetic, Negative Genetic, Synthetic Rescue
DPB4 YDR121W Subunit of DNA pol epsilon and of ISW2 chromatin accessibility complex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
CSE2 YNR010W Subunit of the RNA polymerase II mediator complex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
DPB11 YJL090C DNA replication initiation protein genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
FAR3 YMR052W Protein of unknown function genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
TAF12 YDR145W Subunit (61/68 kDa) of TFIID and SAGA complexes genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
RSC1 YGR056W Component of the RSC chromatin remodeling complex genetic 3 1 2 Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect
POL12 YBL035C B subunit of DNA polymerase alpha-primase complex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
MCM2 YBL023C Protein involved in DNA replication genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
TAF5 YBR198C Subunit (90 kDa) of TFIID and SAGA complexes genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
PSF1 YDR013W Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
TCP1 YDR212W Alpha subunit of chaperonin-containing T-complex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
HTA1 YDR225W Histone H2A genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
IPK1 YDR315C Inositol 1,3,4,5,6-pentakisphosphate 2-kinase genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
LSM1 YJL124C Lsm (Like Sm) protein genetic 3 1 2 Positive Genetic, Positive Genetic, Positive Genetic
ORC3 YLL004W Subunit of the origin recognition complex (ORC) genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
POL1 YNL102W Catalytic subunit of the DNA polymerase I alpha-primase complex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
SWI5 YDR146C Transcription factor that recruits Mediator and Swi/Snf complexes genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
MPH1 YIR002C 3'-5' DNA helicase involved in error-free bypass of DNA lesions genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
MNE1 YOR350C Protein involved in splicing Group I aI5-beta intron from COX1 mRNA genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
MED1 YPR070W Subunit of the RNA polymerase II mediator complex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
TDH2 YJR009C Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), isozyme 2 genetic 3 3 1 Phenotypic Suppression, Synthetic Rescue, Phenotypic Enhancement
FKH1 YIL131C Forkhead family transcription factor regulation 2 2 2 chromatin immunoprecipitation-chip evidence, ChEC-Seq experiments
ASF1 YJL115W Nucleosome assembly factor genetic 2 2 2 Phenotypic Suppression, Synthetic Rescue
POL30 YBR088C Proliferating cell nuclear antigen (PCNA) genetic 2 2 2 Negative Genetic, Synthetic Lethality
TOP1 YOL006C Topoisomerase I genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
RPB3 YIL021W RNA polymerase II third largest subunit B44 genetic 2 2 2 Positive Genetic, Phenotypic Suppression
MSC1 YML128C Protein of unknown function genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
RFC1 YOR217W Subunit of heteropentameric Replication factor C (RF-C) genetic 2 2 2 Dosage Rescue, Negative Genetic
MEC3 YLR288C DNA damage and meiotic pachytene checkpoint protein genetic 2 2 2 Synthetic Rescue, Negative Genetic
TAF1 YGR274C TFIID subunit, involved in RNA pol II transcription initiation genetic 2 2 2 Synthetic Lethality, Negative Genetic
HRQ1 YDR291W 3'-5' DNA helicase of the conserved RecQ family genetic 2 2 2 Positive Genetic, Negative Genetic
DBP7 YKR024C Putative ATP-dependent RNA helicase of the DEAD-box family genetic 2 1 2 Negative Genetic, Negative Genetic
GIM3 YNL153C Subunit of the heterohexameric cochaperone prefoldin complex genetic 2 1 2 Positive Genetic, Positive Genetic
BGL2 YGR282C Endo-beta-1,3-glucanase genetic 2 1 2 Negative Genetic, Negative Genetic
DUN1 YDL101C Cell-cycle checkpoint S/T protein kinase genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
HHT1 YBR010W Histone H3 genetic 2 1 2 Synthetic Rescue, Synthetic Rescue
ELG1 YOR144C Subunit of an alternative replication factor C complex genetic 2 1 2 Synthetic Rescue, Synthetic Rescue
RMI1 YPL024W Subunit of the RecQ (Sgs1p) - Topo III (Top3p) complex genetic 2 1 2 Negative Genetic, Negative Genetic
PRI1 YIR008C Subunit of DNA primase genetic 2 1 2 Negative Genetic, Negative Genetic
TOP3 YLR234W DNA Topoisomerase III genetic 2 1 2 Negative Genetic, Negative Genetic
RSC6 YCR052W Component of the RSC chromatin remodeling complex genetic 2 1 2 Negative Genetic, Negative Genetic
RSC9 YML127W Component of the RSC chromatin remodeling complex genetic 2 1 2 Negative Genetic, Negative Genetic
TOM1 YDR457W E3 ubiquitin ligase of the hect-domain class genetic 2 1 2 Negative Genetic, Negative Genetic
RML2 YEL050C Mitochondrial ribosomal protein of the large subunit (L2) genetic 2 1 2 Negative Genetic, Negative Genetic
HYP2 YEL034W Translation elongation factor eIF-5A genetic 2 1 2 Negative Genetic, Negative Genetic
SFH1 YLR321C Component of the RSC chromatin remodeling complex genetic 2 1 2 Negative Genetic, Negative Genetic
TAF8 YML114C TFIID subunit (65 kDa) genetic 2 1 2 Negative Genetic, Negative Genetic
RPL19B YBL027W Ribosomal 60S subunit protein L19B genetic 2 1 2 Negative Genetic, Negative Genetic
RVS161 YCR009C Amphiphysin-like lipid raft protein genetic 2 1 2 Negative Genetic, Negative Genetic
RVS167 YDR388W Calmodulin-binding actin-associated protein genetic 2 1 2 Negative Genetic, Negative Genetic
PIG2 YIL045W Putative type-1 protein phosphatase targeting subunit genetic 2 1 2 Negative Genetic, Negative Genetic
KCH1 YJR054W Potassium transporter that mediates K+ influx genetic 2 1 2 Negative Genetic, Negative Genetic
IME1 YJR094C Master regulator of meiosis that is active only during meiotic events genetic 2 1 2 Negative Genetic, Negative Genetic
LSM7 YNL147W Lsm (Like Sm) protein genetic 2 1 2 Negative Genetic, Negative Genetic
PPT2 YPL148C Phosphopantetheine:protein transferase (PPTase) genetic 2 1 2 Negative Genetic, Negative Genetic
SIR2 YDL042C Conserved NAD+ dependent histone deacetylase of the Sirtuin family genetic 2 1 2 Synthetic Growth Defect, Synthetic Growth Defect
RAD17 YOR368W Checkpoint protein genetic 2 1 2 Synthetic Rescue, Synthetic Rescue
RAD24 YER173W Checkpoint protein genetic 2 1 2 Synthetic Rescue, Synthetic Rescue
CSG2 YBR036C Endoplasmic reticulum membrane protein genetic 2 1 2 Negative Genetic, Negative Genetic
MMS1 YPR164W Subunit of E3 ubiquitin ligase complex involved in replication repair genetic 2 2 1 Positive Genetic, Synthetic Rescue
YAT1 YAR035W Outer mitochondrial carnitine acetyltransferase genetic 2 2 1 Phenotypic Suppression, Synthetic Rescue
IDP1 YDL066W Mitochondrial NADP-specific isocitrate dehydrogenase genetic 2 2 1 Phenotypic Suppression, Synthetic Rescue
DNA2 YHR164C ATP-dependent 5'-flap endonuclease and DNA helicase genetic 2 1 1 Negative Genetic, Negative Genetic
ACS2 YLR153C Acetyl-coA synthetase isoform genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
CDC20 YGL116W Activator of anaphase-promoting complex/cyclosome (APC/C) genetic 2 1 1 Negative Genetic, Negative Genetic
SEC28 YIL076W Epsilon-COP subunit of the coatomer genetic 2 1 1 Negative Genetic, Negative Genetic
YJR120W YJR120W Protein of unknown function genetic 2 1 1 Negative Genetic, Negative Genetic
MCM7 YBR202W Component of the Mcm2-7 hexameric helicase complex genetic 2 1 1 Negative Genetic, Negative Genetic
SLD5 YDR489W Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) genetic 2 1 1 Negative Genetic, Negative Genetic
MOB2 YFL034C-B Activator of Cbk1p kinase genetic 2 1 1 Negative Genetic, Negative Genetic
RSC8 YFR037C Component of the RSC chromatin remodeling complex genetic 2 1 1 Negative Genetic, Negative Genetic
SLD3 YGL113W Protein involved in the initiation of DNA replication genetic 2 1 1 Negative Genetic, Negative Genetic
ORC6 YHR118C Subunit of the origin recognition complex (ORC) genetic 2 1 1 Negative Genetic, Negative Genetic
POL31 YJR006W Subunit of DNA polymerase delta (polymerase III) genetic 2 1 1 Negative Genetic, Negative Genetic
TAH11 YJR046W DNA replication licensing factor genetic 2 1 1 Negative Genetic, Negative Genetic
MCM5 YLR274W Component of the Mcm2-7 hexameric helicase complex genetic 2 1 1 Negative Genetic, Negative Genetic
TAF13 YML098W TFIID subunit (19 kDa) genetic 2 1 1 Negative Genetic, Negative Genetic
ORC4 YPR162C Subunit of the origin recognition complex (ORC) genetic 2 1 1 Negative Genetic, Negative Genetic
CCS1 YMR038C Copper chaperone for superoxide dismutase Sod1p genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
CPR8 YNR028W Peptidyl-prolyl cis-trans isomerase (cyclophilin) genetic 2 1 1 Negative Genetic, Negative Genetic
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
IXR1 YKL032C Transcriptional repressor that regulates hypoxic genes during normoxia regulation 1 1 1 DNA to cDNA expression microarray evidence
HFI1 YPL254W Adaptor protein required for structural integrity of the SAGA complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MED2 YDL005C Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
REB1 YBR049C RNA polymerase I enhancer binding protein regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MED4 YOR174W Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MED6 YHR058C Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
RSF2 YJR127C Zinc-finger protein regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SPT3 YDR392W Subunit of the SAGA and SAGA-like transcriptional regulatory complexes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
FHL1 YPR104C Regulator of ribosomal protein (RP) transcription regulation 1 1 1 chromatin immunoprecipitation-chip evidence
UME6 YDR207C Rpd3L histone deacetylase complex subunit regulation 1 1 1 chromatin immunoprecipitation-chip evidence
RPD3 YNL330C Histone deacetylase, component of both the Rpd3S and Rpd3L complexes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CKA2 YOR061W Alpha' catalytic subunit of casein kinase 2 (CK2) genetic 1 1 1 Negative Genetic
GAR1 YHR089C Protein component of the H/ACA snoRNP pseudouridylase complex genetic 1 1 1 Negative Genetic
ARP9 YMR033W Component of both the SWI/SNF and RSC chromatin remodeling complexes genetic 1 1 1 Negative Genetic
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit physical 1 1 1 Biochemical Activity
CDC11 YJR076C Component of the septin ring that is required for cytokinesis genetic 1 1 1 Negative Genetic
CKS1 YBR135W Cyclin-dependent protein kinase regulatory subunit and adaptor genetic 1 1 1 Negative Genetic
CPR1 YDR155C Cytoplasmic peptidyl-prolyl cis-trans isomerase (cyclophilin) genetic 1 1 1 Negative Genetic
DOA1 YKL213C WD-repeat protein involved in ubiquitin-mediated protein degradation genetic 1 1 1 Negative Genetic
EAF3 YPR023C Component of the Rpd3S histone deacetylase complex genetic 1 1 1 Negative Genetic
ERO1 YML130C Thiol oxidase required for oxidative protein folding in the ER genetic 1 1 1 Negative Genetic
CCT4 YDL143W Subunit of the cytosolic chaperonin Cct ring complex genetic 1 1 1 Negative Genetic
HHF1 YBR009C Histone H4 physical 1 1 1 Biochemical Activity
HHF1 YBR009C Histone H4 genetic 1 1 1 Synthetic Rescue
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
AEP1 YMR064W Protein required for expression of the mitochondrial OLI1 gene genetic 1 1 1 Negative Genetic
HHF2 YNL030W Histone H4 physical 1 1 1 Biochemical Activity
CWC22 YGR278W Spliceosome-associated protein that is required for pre-mRNA splicing genetic 1 1 1 Negative Genetic
CCT6 YDR188W Subunit of the cytosolic chaperonin Cct ring complex genetic 1 1 1 Negative Genetic
GPH1 YPR160W Glycogen phosphorylase required for the mobilization of glycogen genetic 1 1 1 Negative Genetic
CAF20 YOR276W Phosphoprotein of the mRNA cap-binding complex physical 1 1 1 Affinity Capture-RNA
CDC53 YDL132W Cullin genetic 1 1 1 Positive Genetic
DDC1 YPL194W DNA damage checkpoint protein genetic 1 1 1 Synthetic Rescue
CDC60 YPL160W Cytosolic leucyl tRNA synthetase genetic 1 1 1 Negative Genetic
CDC4 YFL009W F-box protein required for both the G1/S and G2/M phase transitions genetic 1 1 1 Synthetic Growth Defect
HHT1 YBR010W Histone H3 physical 1 1 1 Biochemical Activity
CLB2 YPR119W B-type cyclin involved in cell cycle progression genetic 1 1 1 Synthetic Growth Defect
CDC7 YDL017W S/T kinase and catalytic subunit of DDK (Dbf4-dependent kinase) genetic 1 1 1 Negative Genetic
SFP1 YLR403W Regulates transcription of ribosomal protein and biogenesis genes physical 1 1 1 Two-hybrid
WHI3 YNL197C RNA binding protein that modulates mRNA stability physical 1 1 1 Affinity Capture-RNA
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
PUF2 YPR042C PUF family mRNA-binding protein physical 1 1 1 Affinity Capture-RNA
ISW1 YBR245C ATPase subunit of imitation-switch (ISWI) class chromatin remodelers physical 1 1 1 Affinity Capture-RNA
ISW1 YBR245C ATPase subunit of imitation-switch (ISWI) class chromatin remodelers genetic 1 1 1 Negative Genetic
ORC5 YNL261W Subunit of the origin recognition complex (ORC) genetic 1 1 1 Synthetic Lethality
RTT105 YER104W Chaperone for Replication Protein A complex (RPA) genetic 1 1 1 Negative Genetic
RFA2 YNL312W Subunit of heterotrimeric Replication Protein A (RPA) genetic 1 1 1 Negative Genetic
RFA1 YAR007C Subunit of heterotrimeric Replication Protein A (RPA) genetic 1 1 1 Negative Genetic
RPN6 YDL097C Essential, non-ATPase regulatory subunit of the 26S proteasome lid genetic 1 1 1 Negative Genetic
ORM2 YLR350W Protein that mediates sphingolipid homeostasis genetic 1 1 1 Negative Genetic
SSD1 YDR293C Translational repressor genetic 1 1 1 Negative Genetic
TAF14 YPL129W Subunit of TFIID, TFIIF, INO80, SWI/SNF, and NuA3 complexes genetic 1 1 1 Negative Genetic
SIN3 YOL004W Component of both the Rpd3S and Rpd3L histone deacetylase complexes genetic 1 1 1 Negative Genetic
MED4 YOR174W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
YAF9 YNL107W Subunit of NuA4 histone H4 acetyltransferase and SWR1 complexes genetic 1 1 1 Negative Genetic
RVB1 YDR190C ATP-dependent DNA helicase, also known as pontin genetic 1 1 1 Positive Genetic
PFD1 YJL179W Subunit of heterohexameric prefoldin genetic 1 1 1 Positive Genetic
REI1 YBR267W Cytoplasmic pre-60S factor genetic 1 1 1 Positive Genetic
RVB2 YPL235W ATP-dependent DNA helicase, also known as reptin genetic 1 1 1 Positive Genetic
NUP84 YDL116W Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) genetic 1 1 1 Positive Genetic
LSM6 YDR378C Lsm (Like Sm) protein genetic 1 1 1 Positive Genetic
MCD1 YDL003W Essential alpha-kleisin subunit of the cohesin complex genetic 1 1 1 Synthetic Lethality
VMA9 YCL005W-A Vacuolar H+ ATPase subunit e of the V-ATPase V0 subcomplex genetic 1 1 1 Negative Genetic
PAU10 YDR542W Protein of unknown function genetic 1 1 1 Negative Genetic
YEA6 YEL006W Mitochondrial NAD+ transporter genetic 1 1 1 Negative Genetic
SLX5 YDL013W Subunit of the Slx5-Slx8 SUMO-targeted Ub ligase (STUbL) complex genetic 1 1 1 Negative Genetic
SPH1 YLR313C Protein involved in shmoo formation and bipolar bud site selection genetic 1 1 1 Negative Genetic
WHI5 YOR083W Repressor of G1 transcription genetic 1 1 1 Synthetic Growth Defect
SML1 YML058W Ribonucleotide reductase inhibitor genetic 1 1 1 Synthetic Lethality
RAD52 YML032C Protein involved in homologous recombination genetic 1 1 1 Synthetic Lethality
RAD50 YNL250W Subunit of MRX complex with Mre11p and Xrs2p genetic 1 1 1 Synthetic Lethality
XRS2 YDR369C FHA domain-containing component of the Mre11 complex genetic 1 1 1 Synthetic Lethality
PTC1 YDL006W Type 2C protein phosphatase (PP2C) genetic 1 1 1 Positive Genetic
RTG3 YBL103C bHLH/Zip transcription factor for retrograde (RTG) and TOR pathways genetic 1 1 1 Negative Genetic
MET18 YIL128W Component of cytosolic iron-sulfur protein assembly (CIA) machinery genetic 1 1 1 Negative Genetic
KCS1 YDR017C Inositol hexakisphosphate and inositol heptakisphosphate kinase genetic 1 1 1 Negative Genetic
NPL3 YDR432W RNA-binding protein genetic 1 1 1 Synthetic Rescue
MSH2 YOL090W Protein that binds to DNA mismatches genetic 1 1 1 Phenotypic Enhancement
MLH1 YMR167W Protein required for mismatch repair in mitosis and meiosis genetic 1 1 1 Phenotypic Enhancement
IPP1 YBR011C Cytoplasmic inorganic pyrophosphatase (PPase) genetic 1 1 1 Positive Genetic
PBN1 YCL052C Component of glycosylphosphatidylinositol-mannosyltransferase I genetic 1 1 1 Positive Genetic
YKT6 YKL196C Vesicle membrane protein (v-SNARE) with acyltransferase activity genetic 1 1 1 Positive Genetic
PRP24 YMR268C Splicing factor that reanneals snRNPs during spliceosome recycling genetic 1 1 1 Positive Genetic
PDX3 YBR035C Pyridoxine (pyridoxamine) phosphate oxidase genetic 1 1 1 Positive Genetic
PEX32 YBR168W Peroxisomal integral membrane protein genetic 1 1 1 Positive Genetic
SNF4 YGL115W Activating gamma subunit of the AMP-activated Snf1p kinase complex genetic 1 1 1 Positive Genetic
MRPL17 YNL252C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Positive Genetic
ROM2 YLR371W Guanine nucleotide exchange factor (GEF) for Rho1p and Rho2p genetic 1 1 1 Positive Genetic
NSE4 YDL105W Component of the SMC5-SMC6 complex genetic 1 1 1 Negative Genetic
KIN28 YDL108W Ser/Thr protein kinase and subunit of TFIIK, a TFIIH subassembly genetic 1 1 1 Negative Genetic
TAF10 YDR167W Subunit (145 kDa) of TFIID and SAGA complexes genetic 1 1 1 Negative Genetic
MCM3 YEL032W Protein involved in DNA replication genetic 1 1 1 Negative Genetic
UTR5 YEL035C Protein of unknown function genetic 1 1 1 Negative Genetic
SCC4 YER147C Subunit of cohesin loading factor (Scc2p-Scc4p) genetic 1 1 1 Negative Genetic
RAD3 YER171W 5' to 3' DNA helicase genetic 1 1 1 Negative Genetic
MCM6 YGL201C Protein involved in DNA replication genetic 1 1 1 Negative Genetic
RPN1 YHR027C Non-ATPase base subunit of the 19S RP of the 26S proteasome genetic 1 1 1 Negative Genetic
QNS1 YHR074W Glutamine-dependent NAD(+) synthetase genetic 1 1 1 Negative Genetic
TAO3 YIL129C Component of the RAM signaling network genetic 1 1 1 Negative Genetic
TIM54 YJL054W Component of the mitochondrial TIM22 complex genetic 1 1 1 Negative Genetic
RFA3 YJL173C Subunit of heterotrimeric Replication Protein A (RPA) genetic 1 1 1 Negative Genetic
UTP21 YLR409C Subunit of U3-containing 90S preribosome and SSU processome complexes genetic 1 1 1 Negative Genetic
TAP42 YMR028W Essential protein involved in the TOR signaling pathway genetic 1 1 1 Negative Genetic
TAF3 YPL011C TFIID subunit (47 kDa) genetic 1 1 1 Negative Genetic
SMT3 YDR510W Ubiquitin-like protein of the SUMO family genetic 1 1 1 Negative Genetic
TAD3 YLR316C Subunit of tRNA-specific adenosine-34 deaminase genetic 1 1 1 Negative Genetic
ORC1 YML065W Largest subunit of the origin recognition complex genetic 1 1 1 Negative Genetic
TAF4 YMR005W TFIID subunit (48 kDa) genetic 1 1 1 Negative Genetic
RPC34 YNR003C RNA polymerase III subunit C34 genetic 1 1 1 Negative Genetic
TOA1 YOR194C TFIIA large subunit genetic 1 1 1 Negative Genetic
SMP1 YBR182C MADS-box transcription factor involved in osmotic stress response genetic 1 1 1 Negative Genetic
RPS14A YCR031C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
TFB5 YDR079C-A Component of RNA polymerase II general transcription factor TFIIH genetic 1 1 1 Negative Genetic
SLX8 YER116C Subunit of Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex genetic 1 1 1 Negative Genetic
PUG1 YER185W Plasma membrane protein involved in protoprophyrin and heme transport genetic 1 1 1 Negative Genetic
RPO41 YFL036W Mitochondrial RNA polymerase genetic 1 1 1 Negative Genetic
RMD9 YGL107C Mitochondrial protein that controls mitochondrial gene expression genetic 1 1 1 Negative Genetic
SAP4 YGL229C Protein required for function of the Sit4p protein phosphatase genetic 1 1 1 Negative Genetic
XKS1 YGR194C Xylulokinase genetic 1 1 1 Negative Genetic
NOP10 YHR072W-A Subunit of box H/ACA snoRNP complex genetic 1 1 1 Negative Genetic
SET1 YHR119W Histone methyltransferase, subunit of the COMPASS (Set1C) complex genetic 1 1 1 Negative Genetic
VID28 YIL017C GID Complex subunit, serves as adaptor for regulatory subunit Vid24p genetic 1 1 1 Negative Genetic
MHP1 YJL042W Microtubule-associated protein involved in microtubule organization genetic 1 1 1 Negative Genetic
TRK1 YJL129C Component of the Trk1p-Trk2p potassium transport system genetic 1 1 1 Negative Genetic
YJR149W YJR149W Putative protein of unknown function genetic 1 1 1 Negative Genetic
MRT4 YKL009W Protein involved in mRNA turnover and ribosome assembly genetic 1 1 1 Negative Genetic
TSA1 YML028W Thioredoxin peroxidase genetic 1 1 1 Synthetic Growth Defect
TOF2 YKR010C Protein required for rDNA silencing and mitotic rDNA condensation genetic 1 1 1 Negative Genetic
TCO89 YPL180W Subunit of TORC1 (Tor1p or Tor2p-Kog1p-Lst8p-Tco89p) genetic 1 1 1 Synthetic Rescue
IRC21 YMR073C Protein of unknown function genetic 1 1 1 Negative Genetic
PIF1 YML061C DNA helicase, potent G-quadruplex DNA binder/unwinder genetic 1 1 1 Negative Genetic
SMA2 YML066C Meiosis-specific prospore membrane protein genetic 1 1 1 Negative Genetic
TCB3 YML072C Cortical ER protein involved in ER-plasma membrane tethering genetic 1 1 1 Negative Genetic
RSF1 YMR030W Protein required for respiratory growth genetic 1 1 1 Negative Genetic
POR1 YNL055C Mitochondrial porin (voltage-dependent anion channel) genetic 1 1 1 Negative Genetic
PSY2 YNL201C Subunit of protein phosphatase PP4 complex genetic 1 1 1 Negative Genetic
YKU80 YMR106C Subunit of telomeric Ku complex (Yku70p-Yku80p) genetic 1 1 1 Phenotypic Enhancement
MUD1 YBR119W U1 snRNP A protein genetic 1 1 1 Negative Genetic
OST4 YDL232W Subunit of the oligosaccharyltransferase complex of the ER lumen genetic 1 1 1 Negative Genetic
TPS2 YDR074W Phosphatase subunit of the trehalose-6-P synthase/phosphatase complex genetic 1 1 1 Negative Genetic
UBP3 YER151C Ubiquitin-specific protease that cleaves Ub-protein fusions genetic 1 1 1 Negative Genetic
PDA1 YER178W E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex genetic 1 1 1 Negative Genetic
WSS1 YHR134W SUMO-ligase and SUMO-targeted metalloprotease genetic 1 1 1 Negative Genetic
VPS55 YJR044C Late endosomal protein involved in late endosome to vacuole transport genetic 1 1 1 Negative Genetic
RPL14A YKL006W Ribosomal 60S subunit protein L14A genetic 1 1 1 Negative Genetic
RPL8B YLL045C Ribosomal 60S subunit protein L8A genetic 1 1 1 Negative Genetic
IKI3 YLR384C Subunit of Elongator complex genetic 1 1 1 Negative Genetic
PFK2 YMR205C Beta subunit of heterooctameric phosphofructokinase genetic 1 1 1 Negative Genetic
YME1 YPR024W Catalytic subunit of i-AAA protease complex genetic 1 1 1 Negative Genetic
SUE1 YPR151C Protein required for degradation of unstable forms of cytochrome c genetic 1 1 1 Negative Genetic
MET7 YOR241W Folylpolyglutamate synthetase genetic 1 1 1 Negative Genetic
RGL1 YPL066W Regulator of Rho1p signaling, cofactor of Tus1p genetic 1 1 1 Negative Genetic
RAD53 YPL153C DNA damage response kinase genetic 1 1 1 Dosage Rescue
SAS2 YMR127C Histone acetyltransferase (HAT) catalytic subunit of the SAS complex genetic 1 1 1 Synthetic Rescue
RSC2 YLR357W Component of the RSC chromatin remodeling complex genetic 1 1 1 Synthetic Rescue
YTA7 YGR270W Chromatin-binding ATPase that regulates histone gene expression genetic 1 1 1 Synthetic Rescue
REC8 YPR007C Meiosis-specific component of the sister chromatid cohesion complex genetic 1 1 1 Positive Genetic
TUB4 YLR212C Gamma-tubulin genetic 1 1 1 Synthetic Rescue
RRP6 YOR001W Nuclear exosome exonuclease component genetic 1 1 1 Phenotypic Enhancement
CLG1 YGL215W Cyclin-like protein that interacts with Pho85p genetic 1 1 1 Negative Genetic
GPI16 YHR188C Subunit of the glycosylphosphatidylinositol transamidase complex genetic 1 1 1 Negative Genetic
AMD1 YML035C AMP deaminase genetic 1 1 1 Negative Genetic
BRE5 YNR051C Ubiquitin protease cofactor genetic 1 1 1 Negative Genetic
CTF8 YHR191C Subunit of a complex with Ctf18p genetic 1 1 1 Synthetic Rescue
DBP5 YOR046C Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family genetic 1 1 1 Synthetic Growth Defect
FBP1 YLR377C Fructose-1,6-bisphosphatase genetic 1 1 1 Phenotypic Enhancement
BUD6 YLR319C Actin- and formin-interacting protein genetic 1 1 1 Negative Genetic
ESC2 YDR363W Sumo-like domain protein genetic 1 1 1 Negative Genetic
DOT1 YDR440W Nucleosomal histone H3-Lys79 methylase genetic 1 1 1 Synthetic Rescue
HMT1 YBR034C Nuclear SAM-dependent mono- and asymmetric methyltransferase genetic 1 1 1 Positive Genetic
GPR1 YDL035C Plasma membrane G protein coupled receptor (GPCR) genetic 1 1 1 Negative Genetic
HHT2 YNL031C Histone H3 physical 1 1 1 Biochemical Activity
COQ9 YLR201C Protein required for ubiquinone biosynthesis and respiratory growth genetic 1 1 1 Negative Genetic
DCC1 YCL016C Subunit of a complex with Ctf8p and Ctf18p genetic 1 1 1 Synthetic Rescue
BRL1 YHR036W Essential nuclear envelope/ER integral membrane protein genetic 1 1 1 Negative Genetic
HEM1 YDR232W 5-aminolevulinate synthase genetic 1 1 1 Negative Genetic
CMK2 YOL016C Calmodulin-dependent protein kinase genetic 1 1 1 Negative Genetic
DEG1 YFL001W tRNA:pseudouridine synthase genetic 1 1 1 Negative Genetic
GPI12 YMR281W ER membrane protein involved in the second step of GPI anchor assembly genetic 1 1 1 Negative Genetic
EUG1 YDR518W Protein disulfide isomerase of the endoplasmic reticulum lumen genetic 1 1 1 Negative Genetic
EOS1 YNL080C Protein involved in N-glycosylation genetic 1 1 1 Negative Genetic
ERR1 YOR393W Putative phosphopyruvate hydratase genetic 1 1 1 Negative Genetic
ERG3 YLR056W C-5 sterol desaturase genetic 1 1 1 Positive Genetic
CSM4 YPL200W Protein required for accurate chromosome segregation during meiosis genetic 1 1 1 Negative Genetic
GPI8 YDR331W Catalytic subunit of the ER membrane GPI transamidase complex genetic 1 1 1 Positive Genetic
AIM33 YML087C Protein of unknown function, highly conserved across species genetic 1 1 1 Negative Genetic