Standard name Systematic name Name description Description
DDC1 YPL194W DNA damage checkpoint protein DNA damage checkpoint protein; part of a PCNA-like complex required for DNA damage response, required for pachytene checkpoint to inhibit cell cycle in response to unrepaired recombination intermediates; potential Cdc28p substrate; forms nuclear foci upon DNA replication stress
Visualize the interactome of DDC1
Links to external databases:
SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.050 NaN 0.118
Mito 0.251 NaN NaN
Nucleus 0.773 0.854 0.840
Vac/Vac Memb 0.057 0.183 NaN

GFP localization & abundance

GFP localization GFP abundance
cytoplasm, nucleus 238

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
DDC1 3 1 0 4 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
RAD27 YKL113C 5' to 3' exonuclease, 5' flap endonuclease genetic 14 3 9 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic
POL32 YJR043C Third subunit of DNA polymerase delta genetic 13 5 8 Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Rescue, Phenotypic Suppression, Negative Genetic, Negative Genetic, Negative Genetic
TEL1 YBL088C Protein kinase primarily involved in telomere length regulation genetic 12 5 10 Phenotypic Enhancement, Dosage Rescue, Phenotypic Suppression, Negative Genetic, Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement, Negative Genetic
MEC3 YLR288C DNA damage and meiotic pachytene checkpoint protein physical 12 5 8 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Two-hybrid, Affinity Capture-Western, Affinity Capture-Western, Two-hybrid, Affinity Capture-Western, Co-purification
MRC1 YCL061C S-phase checkpoint protein required for DNA replication genetic 12 4 8 Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement, Negative Genetic, Negative Genetic, Negative Genetic
ELG1 YOR144C Subunit of an alternative replication factor C complex genetic 11 4 7 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Dosage Rescue, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
CSM3 YMR048W Replication fork associated factor genetic 11 2 7 Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic
DPB11 YJL090C DNA replication initiation protein physical 9 3 5 Two-hybrid, Two-hybrid, Reconstituted Complex, Reconstituted Complex, Two-hybrid, Two-hybrid, Two-hybrid, Affinity Capture-Western, Affinity Capture-Western
DPB11 YJL090C DNA replication initiation protein genetic 8 5 6 Negative Genetic, Phenotypic Suppression, Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect
RAD5 YLR032W DNA helicase/Ubiquitin ligase genetic 8 3 6 Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Dosage Lethality
CTF8 YHR191C Subunit of a complex with Ctf18p genetic 8 2 6 Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic
DCC1 YCL016C Subunit of a complex with Ctf8p and Ctf18p genetic 8 2 5 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic
RAD17 YOR368W Checkpoint protein physical 7 3 5 Affinity Capture-Western, Affinity Capture-Western, Co-fractionation, Co-fractionation, Two-hybrid, Two-hybrid, Affinity Capture-Western
TOF1 YNL273W Subunit of a replication-pausing checkpoint complex genetic 7 3 5 Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Lethality, Negative Genetic, Negative Genetic
POL3 YDL102W Catalytic subunit of DNA polymerase delta genetic 6 3 5 Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic
TSA1 YML028W Thioredoxin peroxidase genetic 6 2 5 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic
DUN1 YDL101C Cell-cycle checkpoint S/T protein kinase genetic 6 2 5 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic
CTF18 YMR078C Subunit of a complex with Ctf8p genetic 6 3 4 Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
CDC7 YDL017W S/T kinase and catalytic subunit of DDK (Dbf4-dependent kinase) genetic 6 2 4 Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
DNA2 YHR164C ATP-dependent 5'-flap endonuclease and DNA helicase genetic 5 2 3 Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Enhancement
RFA1 YAR007C Subunit of heterotrimeric Replication Protein A (RPA) genetic 4 2 4 Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Lethality
CDC13 YDL220C Single stranded DNA-binding protein found at TG1-3 telomere G-tails genetic 4 4 3 Phenotypic Suppression, Synthetic Rescue, Synthetic Growth Defect, Positive Genetic
SLX4 YLR135W Endonuclease involved in processing DNA genetic 4 3 3 Negative Genetic, Synthetic Rescue, Phenotypic Suppression, Phenotypic Suppression
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 4 3 3 Synthetic Rescue, Phenotypic Enhancement, Synthetic Rescue, Phenotypic Suppression
MEC3 YLR288C DNA damage and meiotic pachytene checkpoint protein genetic 4 2 3 Dosage Rescue, Dosage Rescue, Dosage Growth Defect, Dosage Growth Defect
CDC8 YJR057W Nucleoside monophosphate and nucleoside diphosphate kinase genetic 4 2 3 Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic
RTT109 YLL002W Histone acetyltransferase genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
MCM2 YBL023C Protein involved in DNA replication genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
NNK1 YKL171W Protein kinase genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
REV7 YIL139C Accessory subunit of DNA polymerase zeta physical 4 4 1 Two-hybrid, Affinity Capture-Western, Reconstituted Complex, Co-localization
SRS2 YJL092W DNA helicase and DNA-dependent ATPase genetic 3 3 3 Phenotypic Enhancement, Dosage Rescue, Synthetic Rescue
APN1 YKL114C Major apurinic/apyrimidinic endonuclease genetic 3 3 3 Negative Genetic, Phenotypic Enhancement, Synthetic Rescue
PRI1 YIR008C Subunit of DNA primase genetic 3 2 3 Synthetic Lethality, Negative Genetic, Negative Genetic
RAD18 YCR066W E3 ubiquitin ligase genetic 3 2 3 Synthetic Growth Defect, Negative Genetic, Negative Genetic
RTT107 YHR154W BRCA1 C-terminal domain protein needed for recovery from DNA damage genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
ORC3 YLL004W Subunit of the origin recognition complex (ORC) genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
SLD2 YKL108W Single-stranded DNA origin-binding and annealing protein genetic 3 3 2 Dosage Lethality, Phenotypic Enhancement, Synthetic Growth Defect
CDC45 YLR103C DNA replication initiation factor genetic 3 2 2 Synthetic Growth Defect, Negative Genetic, Negative Genetic
CDC6 YJL194W Essential ATP-binding protein required for DNA replication genetic 3 2 2 Synthetic Lethality, Negative Genetic, Negative Genetic
NUP60 YAR002W FG-nucleoporin component of central core of the nuclear pore complex genetic 3 2 2 Synthetic Growth Defect, Negative Genetic, Negative Genetic
RAD9 YDR217C DNA damage-dependent checkpoint protein genetic 3 2 2 Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Enhancement
POL1 YNL102W Catalytic subunit of the DNA polymerase I alpha-primase complex genetic 3 2 2 Synthetic Growth Defect, Negative Genetic, Negative Genetic
RFC4 YOL094C Subunit of heteropentameric Replication factor C (RF-C) genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
POL12 YBL035C B subunit of DNA polymerase alpha-primase complex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
ORC2 YBR060C Subunit of the origin recognition complex (ORC) genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
PSF1 YDR013W Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
MCM7 YBR202W Component of the Mcm2-7 hexameric helicase complex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
SLD3 YGL113W Protein involved in the initiation of DNA replication genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
ORC4 YPR162C Subunit of the origin recognition complex (ORC) genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
DBF4 YDR052C Regulatory subunit of Cdc7p-Dbf4p kinase complex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
BMH1 YER177W 14-3-3 protein, major isoform genetic 2 2 2 Synthetic Lethality, Negative Genetic
RAD17 YOR368W Checkpoint protein genetic 2 2 2 Dosage Rescue, Dosage Growth Defect
RAD24 YER173W Checkpoint protein physical 2 2 2 Two-hybrid, Co-localization
ORC6 YHR118C Subunit of the origin recognition complex (ORC) genetic 2 2 2 Synthetic Lethality, Negative Genetic
SMC6 YLR383W Subunit of the SMC5-SMC6 complex genetic 2 2 2 Phenotypic Enhancement, Dosage Rescue
POL2 YNL262W Catalytic subunit of DNA polymerase (II) epsilon genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit physical 2 1 2 Biochemical Activity, Biochemical Activity
RED1 YLR263W Protein component of the synaptonemal complex axial elements physical 2 1 2 Two-hybrid, Two-hybrid
POL30 YBR088C Proliferating cell nuclear antigen (PCNA) genetic 2 1 2 Negative Genetic, Negative Genetic
DOT1 YDR440W Nucleosomal histone H3-Lys79 methylase genetic 2 1 2 Synthetic Growth Defect, Synthetic Growth Defect
YPC1 YBR183W Alkaline ceramidase genetic 2 1 2 Negative Genetic, Negative Genetic
PDA1 YER178W E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex genetic 2 1 2 Negative Genetic, Negative Genetic
NUT1 YGL151W Component of the RNA polymerase II mediator complex genetic 2 1 2 Negative Genetic, Negative Genetic
OM45 YIL136W Mitochondrial outer membrane protein of unknown function genetic 2 1 2 Negative Genetic, Negative Genetic
SAC1 YKL212W Phosphatidylinositol phosphate phosphatase genetic 2 1 2 Negative Genetic, Negative Genetic
DIA2 YOR080W Origin-binding F-box protein genetic 2 1 2 Negative Genetic, Negative Genetic
TEL2 YGR099W Subunit of the ASTRA complex, involved in chromatin remodeling genetic 2 1 2 Negative Genetic, Negative Genetic
MCM5 YLR274W Component of the Mcm2-7 hexameric helicase complex genetic 2 1 2 Negative Genetic, Negative Genetic
SIC1 YLR079W Cyclin-dependent kinase inhibitor (CKI) genetic 2 1 2 Negative Genetic, Negative Genetic
HPR1 YDR138W Subunit of THO/TREX complexes genetic 2 2 1 Synthetic Lethality, Synthetic Growth Defect
DPB4 YDR121W Subunit of DNA pol epsilon and of ISW2 chromatin accessibility complex genetic 2 2 1 Phenotypic Enhancement, Synthetic Growth Defect
REV1 YOR346W Deoxycytidyl transferase genetic 2 2 1 Synthetic Growth Defect, Phenotypic Enhancement
ISW2 YOR304W ATP-dependent DNA translocase involved in chromatin remodeling genetic 2 2 1 Phenotypic Suppression, Synthetic Rescue
NHP10 YDL002C Non-essential INO80 chromatin remodeling complex subunit genetic 2 2 1 Phenotypic Suppression, Synthetic Rescue
EXO1 YOR033C 5'-3' exonuclease and flap-endonuclease genetic 2 2 1 Synthetic Rescue, Phenotypic Suppression
CSE2 YNR010W Subunit of the RNA polymerase II mediator complex genetic 2 1 1 Negative Genetic, Negative Genetic
CDC9 YDL164C DNA ligase I found in nucleus and mitochondria genetic 2 1 1 Negative Genetic, Negative Genetic
SUL1 YBR294W High affinity sulfate permease of the SulP anion transporter family genetic 2 1 1 Negative Genetic, Negative Genetic
PPM1 YDR435C Carboxyl methyltransferase genetic 2 1 1 Negative Genetic, Negative Genetic
MTO1 YGL236C Mitochondrial protein genetic 2 1 1 Negative Genetic, Negative Genetic
PTH1 YHR189W One of two mitochondrially-localized peptidyl-tRNA hydrolases genetic 2 1 1 Negative Genetic, Negative Genetic
VPS35 YJL154C Endosomal subunit of membrane-associated retromer complex genetic 2 1 1 Positive Genetic, Positive Genetic
UBX6 YJL048C UBX (ubiquitin regulatory X) domain-containing protein genetic 2 1 1 Negative Genetic, Negative Genetic
TPO5 YKL174C Protein involved in excretion of putrescine and spermidine genetic 2 1 1 Negative Genetic, Negative Genetic
RPL8B YLL045C Ribosomal 60S subunit protein L8A genetic 2 1 1 Positive Genetic, Positive Genetic
OCA2 YNL056W Protein of unknown function genetic 2 1 1 Positive Genetic, Positive Genetic
HPF1 YOL155C Haze-protective mannoprotein genetic 2 1 1 Negative Genetic, Negative Genetic
HMI1 YOL095C Mitochondrial inner membrane localized ATP-dependent DNA helicase genetic 2 1 1 Negative Genetic, Negative Genetic
SLD5 YDR489W Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) genetic 2 1 1 Negative Genetic, Negative Genetic
PSF2 YJL072C Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) genetic 2 1 1 Negative Genetic, Negative Genetic
POL31 YJR006W Subunit of DNA polymerase delta (polymerase III) genetic 2 1 1 Negative Genetic, Negative Genetic
PRI2 YKL045W Subunit of DNA primase genetic 2 1 1 Negative Genetic, Negative Genetic
COQ2 YNR041C Para hydroxybenzoate polyprenyl transferase genetic 2 1 1 Negative Genetic, Negative Genetic
SPT10 YJL127C Histone H3 acetylase with a role in transcriptional regulation regulation 1 1 1 DNA to cDNA expression microarray evidence
MED2 YDL005C Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
TFC7 YOR110W RNA pol III transcription initiation factor complex (TFIIIC) subunit regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CDC73 YLR418C Component of the Paf1p complex genetic 1 1 1 Negative Genetic
CHD1 YER164W Chromatin remodeler that regulates various aspects of transcription genetic 1 1 1 Negative Genetic
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
BET3 YKR068C Core component of transport protein particle (TRAPP) complexes I-III genetic 1 1 1 Negative Genetic
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit genetic 1 1 1 Dosage Lethality
BUD31 YCR063W Component of the SF3b subcomplex of the U2 snRNP genetic 1 1 1 Positive Genetic
DCP2 YNL118C Catalytic subunit of Dcp1p-Dcp2p decapping enzyme complex genetic 1 1 1 Positive Genetic
BUD3 YCL014W Guanine nucleotide exchange factor (GEF) for Cdc42p genetic 1 1 1 Negative Genetic
AFG2 YLR397C ATPase of the CDC48/PAS1/SEC18 (AAA) family, forms a hexameric complex genetic 1 1 1 Negative Genetic
BLM10 YFL007W Proteasome activator genetic 1 1 1 Negative Genetic
BDH2 YAL061W Putative medium-chain alcohol dehydrogenase with similarity to BDH1 genetic 1 1 1 Negative Genetic
CAF20 YOR276W Phosphoprotein of the mRNA cap-binding complex physical 1 1 1 Affinity Capture-RNA
RFC4 YOL094C Subunit of heteropentameric Replication factor C (RF-C) physical 1 1 1 Affinity Capture-MS
SUV3 YPL029W ATP-dependent RNA helicase physical 1 1 1 Affinity Capture-MS
RAD24 YER173W Checkpoint protein genetic 1 1 1 Dosage Rescue
RAD52 YML032C Protein involved in homologous recombination physical 1 1 1 Co-localization
REV7 YIL139C Accessory subunit of DNA polymerase zeta genetic 1 1 1 Synthetic Growth Defect
NHP6A YPR052C High-mobility group (HMG) protein physical 1 1 1 PCA
NHP6B YBR089C-A High-mobility group (HMG) protein physical 1 1 1 PCA
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-RNA
RAD53 YPL153C DNA damage response kinase physical 1 1 1 Biochemical Activity
RAD53 YPL153C DNA damage response kinase genetic 1 1 1 Synthetic Growth Defect
MCM10 YIL150C Essential chromatin-associated protein physical 1 1 1 Affinity Capture-Western
MCM10 YIL150C Essential chromatin-associated protein genetic 1 1 1 Negative Genetic
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
SLX4 YLR135W Endonuclease involved in processing DNA physical 1 1 1 Affinity Capture-Western
RTT107 YHR154W BRCA1 C-terminal domain protein needed for recovery from DNA damage physical 1 1 1 Affinity Capture-Western
HXT17 YNR072W Putative transmembrane polyol transporter genetic 1 1 1 Synthetic Lethality
YME1 YPR024W Catalytic subunit of i-AAA protease complex genetic 1 1 1 Synthetic Lethality
RTT105 YER104W Chaperone for Replication Protein A complex (RPA) genetic 1 1 1 Negative Genetic
NUP84 YDL116W Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) genetic 1 1 1 Negative Genetic
TAF12 YDR145W Subunit (61/68 kDa) of TFIID and SAGA complexes genetic 1 1 1 Negative Genetic
UBC13 YDR092W E2 ubiquitin-conjugating enzyme genetic 1 1 1 Negative Genetic
RFC5 YBR087W Subunit of heteropentameric Replication factor C (RF-C) genetic 1 1 1 Negative Genetic
SET6 YPL165C SET domain protein of unknown function genetic 1 1 1 Negative Genetic
GIM3 YNL153C Subunit of the heterohexameric cochaperone prefoldin complex genetic 1 1 1 Negative Genetic
TFA2 YKR062W TFIIE small subunit genetic 1 1 1 Negative Genetic
RFA2 YNL312W Subunit of heterotrimeric Replication Protein A (RPA) genetic 1 1 1 Negative Genetic
TFG2 YGR005C TFIIF (Transcription Factor II) middle subunit genetic 1 1 1 Positive Genetic
RAD14 YMR201C Subunit of Nucleotide Excision Repair Factor 1 (NEF1) genetic 1 1 1 Phenotypic Enhancement
SAF1 YBR280C F-Box protein involved in proteasome-dependent degradation of Aah1p genetic 1 1 1 Negative Genetic
YCL002C YCL002C Putative protein of unknown function genetic 1 1 1 Negative Genetic
YCR102C YCR102C Putative quinone oxidoreductase genetic 1 1 1 Negative Genetic
RPL13A YDL082W Ribosomal 60S subunit protein L13A genetic 1 1 1 Negative Genetic
NVJ3 YDR179W-A Protein with a potential role in tethering ER and vacuoles genetic 1 1 1 Negative Genetic
YGL235W YGL235W Putative protein of unknown function genetic 1 1 1 Negative Genetic
YIL165C YIL165C Putative protein of unknown function genetic 1 1 1 Negative Genetic
YIL152W YIL152W Putative protein of unknown function genetic 1 1 1 Negative Genetic
YIR043C YIR043C Blocked reading frame genetic 1 1 1 Negative Genetic
NCE101 YJL205C Protein of unknown function genetic 1 1 1 Negative Genetic
PIR5 YJL160C Putative protein of unknown function genetic 1 1 1 Negative Genetic
PHO86 YJL117W Endoplasmic reticulum (ER) resident protein genetic 1 1 1 Negative Genetic
RBH2 YJR030C Putative protein of unknown function genetic 1 1 1 Positive Genetic
IME1 YJR094C Master regulator of meiosis that is active only during meiotic events genetic 1 1 1 Negative Genetic
STE24 YJR117W Highly conserved zinc metalloprotease genetic 1 1 1 Negative Genetic
VPS70 YJR126C Protein of unknown function involved in vacuolar protein sorting genetic 1 1 1 Negative Genetic
KKQ8 YKL168C Putative serine/threonine protein kinase with unknown cellular role genetic 1 1 1 Negative Genetic
PGM1 YKL127W Phosphoglucomutase, minor isoform genetic 1 1 1 Positive Genetic
FMP46 YKR049C Putative redox protein containing a thioredoxin fold genetic 1 1 1 Negative Genetic
RPL40B YKR094C Ubiquitin-ribosomal 60S subunit protein L40B fusion protein genetic 1 1 1 Negative Genetic
PUN1 YLR414C Plasma membrane protein with a role in cell wall integrity genetic 1 1 1 Negative Genetic
PDL32 YMR087W Putative ADP-ribose-1''-monophosphatase genetic 1 1 1 Negative Genetic
YMR155W YMR155W Putative protein of unknown function genetic 1 1 1 Negative Genetic
SPO1 YNL012W Meiosis-specific prospore protein genetic 1 1 1 Negative Genetic
MET22 YOL064C Bisphosphate-3'-nucleotidase genetic 1 1 1 Positive Genetic
YOL036W YOL036W Protein of unknown function genetic 1 1 1 Negative Genetic
INP53 YOR109W Polyphosphatidylinositol phosphatase genetic 1 1 1 Negative Genetic
HAP5 YOR358W Subunit of the Hap2p/3p/4p/5p CCAAT-binding complex genetic 1 1 1 Negative Genetic
MED1 YPR070W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
SLM3 YDL033C tRNA-specific 2-thiouridylase genetic 1 1 1 Synthetic Growth Defect
HTA1 YDR225W Histone H2A genetic 1 1 1 Synthetic Growth Defect
KAR3 YPR141C Minus-end-directed microtubule motor genetic 1 1 1 Synthetic Growth Defect
RNR4 YGR180C Ribonucleotide-diphosphate reductase (RNR) small subunit genetic 1 1 1 Synthetic Lethality
SOD1 YJR104C Cytosolic copper-zinc superoxide dismutase genetic 1 1 1 Synthetic Lethality
PRM7 YDL039C Pheromone-regulated protein genetic 1 1 1 Negative Genetic
HST4 YDR191W NAD(+)-dependent protein deacetylase genetic 1 1 1 Synthetic Rescue
HST3 YOR025W Sirtuin, histone H3 deacetylase genetic 1 1 1 Synthetic Rescue
TOP1 YOL006C Topoisomerase I genetic 1 1 1 Synthetic Growth Defect
RFX1 YLR176C Major transcriptional repressor of DNA-damage-regulated genes genetic 1 1 1 Synthetic Rescue
RUB1 YDR139C Ubiquitin-like protein with similarity to mammalian NEDD8 genetic 1 1 1 Synthetic Growth Defect
RAD30 YDR419W DNA polymerase eta genetic 1 1 1 Synthetic Growth Defect
TPP1 YMR156C DNA 3'-phosphatase genetic 1 1 1 Synthetic Rescue
RAD1 YPL022W Single-stranded DNA endonuclease (with Rad10p) genetic 1 1 1 Synthetic Rescue
HRQ1 YDR291W 3'-5' DNA helicase of the conserved RecQ family genetic 1 1 1 Negative Genetic
SNF2 YOR290C Catalytic subunit of the SWI/SNF chromatin remodeling complex genetic 1 1 1 Synthetic Growth Defect
RTT106 YNL206C Histone chaperone genetic 1 1 1 Synthetic Growth Defect
RLF2 YPR018W Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1) genetic 1 1 1 Synthetic Growth Defect
MCM6 YGL201C Protein involved in DNA replication genetic 1 1 1 Negative Genetic
MED11 YMR112C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
RFC1 YOR217W Subunit of heteropentameric Replication factor C (RF-C) genetic 1 1 1 Negative Genetic
TSC13 YDL015C Enoyl reductase genetic 1 1 1 Negative Genetic
PRE4 YFR050C Beta 7 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
RFC2 YJR068W Subunit of heteropentameric Replication factor C (RF-C) genetic 1 1 1 Negative Genetic
ORC1 YML065W Largest subunit of the origin recognition complex genetic 1 1 1 Negative Genetic
GPI12 YMR281W ER membrane protein involved in the second step of GPI anchor assembly genetic 1 1 1 Negative Genetic
PUP1 YOR157C Beta 2 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
DFR1 YOR236W Dihydrofolate reductase involved in tetrahydrofolate biosynthesis genetic 1 1 1 Negative Genetic
DPB3 YBR278W Third-largest subunit of DNA polymerase II (DNA polymerase epsilon) genetic 1 1 1 Negative Genetic
GLT1 YDL171C NAD(+)-dependent glutamate synthase (GOGAT) genetic 1 1 1 Negative Genetic
MCM21 YDR318W Component of the kinetochore sub-complex COMA genetic 1 1 1 Negative Genetic
ENO1 YGR254W Enolase I, a phosphopyruvate hydratase genetic 1 1 1 Negative Genetic
YHR050W-A YHR050W-A Protein of unknown function genetic 1 1 1 Negative Genetic
ROF1 YHR177W Putative transcription factor containing a WOPR domain genetic 1 1 1 Negative Genetic
DPB2 YPR175W Second largest subunit of DNA polymerase II (DNA polymerase epsilon) genetic 1 1 1 Synthetic Lethality
SMA2 YML066C Meiosis-specific prospore membrane protein genetic 1 1 1 Negative Genetic
SCH9 YHR205W AGC family protein kinase genetic 1 1 1 Synthetic Growth Defect
SLX8 YER116C Subunit of Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex genetic 1 1 1 Negative Genetic
YKU80 YMR106C Subunit of telomeric Ku complex (Yku70p-Yku80p) genetic 1 1 1 Phenotypic Enhancement
UBC4 YBR082C Ubiquitin-conjugating enzyme (E2) genetic 1 1 1 Negative Genetic
RAD59 YDL059C Protein involved DNA double-strand break repair genetic 1 1 1 Negative Genetic
TRM10 YOL093W tRNA methyltransferase genetic 1 1 1 Negative Genetic
NEO1 YIL048W Phospholipid translocase (flippase) genetic 1 1 1 Negative Genetic
FMN1 YDR236C Riboflavin kinase, produces riboflavin monophosphate (FMN) genetic 1 1 1 Positive Genetic
IRC25 YLR021W Component of a heterodimeric Poc4p-Irc25p chaperone genetic 1 1 1 Positive Genetic
HAP3 YBL021C Subunit of the Hap2p/3p/4p/5p CCAAT-binding complex genetic 1 1 1 Negative Genetic
SGF29 YCL010C Component of the HAT/Core module of the SAGA, SLIK, and ADA complexes genetic 1 1 1 Negative Genetic
RRM3 YHR031C DNA helicase involved in rDNA replication and Ty1 transposition genetic 1 1 1 Negative Genetic
MPH1 YIR002C 3'-5' DNA helicase involved in error-free bypass of DNA lesions genetic 1 1 1 Negative Genetic
RPL14A YKL006W Ribosomal 60S subunit protein L14A genetic 1 1 1 Negative Genetic
TAF8 YML114C TFIID subunit (65 kDa) genetic 1 1 1 Negative Genetic
PDS5 YMR076C Cohesion maintenance factor genetic 1 1 1 Negative Genetic
UTP15 YMR093W Nucleolar protein genetic 1 1 1 Negative Genetic
RCE1 YMR274C Type II CAAX prenyl protease genetic 1 1 1 Negative Genetic
HDA1 YNL021W Catalytic subunit of class II HDA1 histone deacetylase complex genetic 1 1 1 Negative Genetic
ILV1 YER086W Threonine deaminase, catalyzes first step in isoleucine biosynthesis genetic 1 1 1 Negative Genetic
HTZ1 YOL012C Histone variant H2AZ genetic 1 1 1 Synthetic Growth Defect
MEC1 YBR136W Genome integrity checkpoint protein and PI kinase superfamily member genetic 1 1 1 Phenotypic Suppression
TUB4 YLR212C Gamma-tubulin genetic 1 1 1 Synthetic Growth Defect
CTF4 YPR135W Chromatin-associated protein genetic 1 1 1 Synthetic Growth Defect
CBR1 YIL043C Cytochrome b reductase and NADH-dependent reductase for Dph3p genetic 1 1 1 Negative Genetic
APC11 YDL008W Catalytic core subunit, Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 1 1 1 Negative Genetic
CBF1 YJR060W Basic helix-loop-helix (bHLH) protein genetic 1 1 1 Negative Genetic
CSE4 YKL049C Centromeric histone H3-like protein genetic 1 1 1 Positive Genetic
DCD1 YHR144C Deoxycytidine monophosphate (dCMP) deaminase genetic 1 1 1 Negative Genetic
CST9 YLR394W SUMO E3 ligase physical 1 1 1 Affinity Capture-Western
CCS1 YMR038C Copper chaperone for superoxide dismutase Sod1p genetic 1 1 1 Synthetic Lethality
BCH1 YMR237W Member of the ChAPs family (Chs5p-Arf1p-binding proteins) genetic 1 1 1 Negative Genetic
CLA4 YNL298W Cdc42p-activated signal transducing kinase genetic 1 1 1 Synthetic Growth Defect
APN2 YBL019W Class II abasic (AP) endonuclease involved in repair of DNA damage genetic 1 1 1 Phenotypic Enhancement
CAJ1 YER048C Nuclear type II J heat shock protein of the E. coli dnaJ family genetic 1 1 1 Negative Genetic
CDC1 YDR182W Putative mannose-ethanolamine phosphate phosphodiesterase genetic 1 1 1 Negative Genetic