Standard name Systematic name Name description Description
DPB2 YPR175W Second largest subunit of DNA polymerase II (DNA polymerase epsilon) Second largest subunit of DNA polymerase II (DNA polymerase epsilon); required for maintenance of fidelity of chromosomal replication; essential motif in C-terminus is required for formation of the four-subunit Pol epsilon; expression peaks at the G1/S phase boundary; Cdc28p substrate
Visualize the interactome of DPB2
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)
G1/S 40

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.461 0.352 0.506
Nucleus 0.124 0.167 0.395
Vac/Vac Memb 0.438 0.571 0.170

GFP localization & abundance

GFP localization GFP abundance
cytoplasm, nucleus 3110

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
DPB2 2 0 0 0 5

Enzyme information

Catalyzed reactions in Yeast8

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
POL2 YNL262W Catalytic subunit of DNA polymerase (II) epsilon physical 33 7 24 Affinity Capture-MS, Affinity Capture-Western, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Co-purification, Co-purification, Co-fractionation, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Co-crystal Structure, Affinity Capture-Western, Co-purification, Two-hybrid, Two-hybrid, Two-hybrid, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Two-hybrid, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western
POL2 YNL262W Catalytic subunit of DNA polymerase (II) epsilon genetic 8 4 7 Dosage Rescue, Synthetic Lethality, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Lethality
DPB4 YDR121W Subunit of DNA pol epsilon and of ISW2 chromatin accessibility complex physical 8 3 7 Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western
PSF1 YDR013W Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) physical 8 3 5 Two-hybrid, Affinity Capture-Western, Two-hybrid, Two-hybrid, Affinity Capture-Western, Two-hybrid, Reconstituted Complex, Affinity Capture-Western
DPB3 YBR278W Third-largest subunit of DNA polymerase II (DNA polymerase epsilon) physical 7 3 6 Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western
CDC45 YLR103C DNA replication initiation factor physical 6 2 6 Affinity Capture-Western, Affinity Capture-Western, Co-purification, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western
SLD5 YDR489W Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) physical 4 4 4 Affinity Capture-Western, Co-purification, Reconstituted Complex, Affinity Capture-MS
CTF18 YMR078C Subunit of a complex with Ctf8p physical 4 2 4 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western
PSF2 YJL072C Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) physical 4 2 4 Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western
CTF4 YPR135W Chromatin-associated protein physical 4 3 3 Affinity Capture-MS, Two-hybrid, Two-hybrid, Affinity Capture-Western
MRC1 YCL061C S-phase checkpoint protein required for DNA replication physical 3 2 3 Two-hybrid, Affinity Capture-Western, Affinity Capture-Western
PSF3 YOL146W Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) physical 3 3 2 Affinity Capture-Western, Two-hybrid, Reconstituted Complex
MMS21 YEL019C Highly conserved SUMO E3 ligase subunit of SMC5-SMC6 complex regulation 3 3 1 co-immunoprecipitation evidence, in vitro sumoylation assay evidence, qualitative western immunoblotting evidence
MCM5 YLR274W Component of the Mcm2-7 hexameric helicase complex physical 2 2 2 Co-purification, Affinity Capture-Western
MCM4 YPR019W Essential helicase component of heterohexameric MCM2-7 complexes physical 2 2 2 Affinity Capture-MS, Affinity Capture-Western
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit physical 2 1 2 Biochemical Activity, Biochemical Activity
DPB2 YPR175W Second largest subunit of DNA polymerase II (DNA polymerase epsilon) physical 2 1 2 Two-hybrid, Two-hybrid
IMD3 YLR432W Inosine monophosphate dehydrogenase physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
MCM3 YEL032W Protein involved in DNA replication physical 2 1 2 Affinity Capture-Western, Affinity Capture-Western
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 2 1 2 Affinity Capture-RNA, Affinity Capture-RNA
DCC1 YCL016C Subunit of a complex with Ctf8p and Ctf18p physical 2 1 2 Affinity Capture-Western, Affinity Capture-Western
DPB11 YJL090C DNA replication initiation protein genetic 2 2 1 Dosage Rescue, Synthetic Lethality
TRF5 YNL299W Non-canonical poly(A) polymerase physical 2 1 1 Two-hybrid, Two-hybrid
FKH1 YIL131C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SFP1 YLR403W Regulates transcription of ribosomal protein and biogenesis genes regulation 1 1 1 DNA to cDNA expression microarray evidence
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
RGR1 YLR071C Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
REB1 YBR049C RNA polymerase I enhancer binding protein regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SPT7 YBR081C Subunit of the SAGA transcriptional regulatory complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MBP1 YDL056W Transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
DED1 YOR204W ATP-dependent DEAD-box RNA helicase with strand-annealing activity physical 1 1 1 Affinity Capture-MS
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
CDC14 YFR028C Protein phosphatase required for mitotic exit genetic 1 1 1 Synthetic Lethality
DOA1 YKL213C WD-repeat protein involved in ubiquitin-mediated protein degradation physical 1 1 1 Affinity Capture-MS
DPB4 YDR121W Subunit of DNA pol epsilon and of ISW2 chromatin accessibility complex genetic 1 1 1 Synthetic Growth Defect
HTB2 YBL002W Histone H2B physical 1 1 1 Affinity Capture-MS
YKU80 YMR106C Subunit of telomeric Ku complex (Yku70p-Yku80p) physical 1 1 1 Affinity Capture-MS
NOG1 YPL093W Putative GTPase physical 1 1 1 Affinity Capture-MS
NUG1 YER006W GTPase that associates with nuclear 60S pre-ribosomes physical 1 1 1 Affinity Capture-MS
RFA1 YAR007C Subunit of heterotrimeric Replication Protein A (RPA) physical 1 1 1 Affinity Capture-Western
MBA1 YBR185C Membrane-associated mitochondrial ribosome receptor physical 1 1 1 Affinity Capture-MS
STE50 YCL032W Adaptor protein for various signaling pathways physical 1 1 1 Affinity Capture-MS
RPN4 YDL020C Transcription factor that stimulates expression of proteasome genes physical 1 1 1 Affinity Capture-MS
PBP4 YDL053C Pbp1p binding protein physical 1 1 1 Affinity Capture-MS
HMO1 YDR174W Chromatin associated high mobility group (HMG) family member physical 1 1 1 Affinity Capture-MS
LEU1 YGL009C Isopropylmalate isomerase physical 1 1 1 Affinity Capture-MS
TIF4632 YGL049C Translation initiation factor eIF4G and scaffold protein physical 1 1 1 Affinity Capture-MS
UTP22 YGR090W Component of the small-subunit processome physical 1 1 1 Affinity Capture-MS
YGR126W YGR126W Putative protein of unknown function physical 1 1 1 Affinity Capture-MS
LSM12 YHR121W Protein of unknown function that may function in RNA processing physical 1 1 1 Affinity Capture-MS
HCA4 YJL033W DEAD box RNA helicase physical 1 1 1 Affinity Capture-MS
STM1 YLR150W Protein required for optimal translation under nutrient stress physical 1 1 1 Affinity Capture-MS
ORC1 YML065W Largest subunit of the origin recognition complex physical 1 1 1 Affinity Capture-MS
NOP12 YOL041C Nucleolar protein involved in pre-25S rRNA processing physical 1 1 1 Affinity Capture-MS
TMA46 YOR091W Protein of unknown function that associates with translating ribosomes physical 1 1 1 Affinity Capture-MS
PRT1 YOR361C eIF3b subunit of the eukaryotic translation initiation factor 3 (eIF3) physical 1 1 1 Affinity Capture-MS
RRP12 YPL012W Protein required for export of the ribosomal subunits physical 1 1 1 Affinity Capture-MS
NOP53 YPL146C Nucleolar protein physical 1 1 1 Affinity Capture-MS
ORC4 YPR162C Subunit of the origin recognition complex (ORC) physical 1 1 1 Affinity Capture-MS
RPS6A YPL090C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
PAB1 YER165W Poly(A) binding protein physical 1 1 1 Affinity Capture-MS
RPS4A YJR145C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
HOG1 YLR113W Mitogen-activated protein kinase involved in osmoregulation physical 1 1 1 Affinity Capture-Western
SLD2 YKL108W Single-stranded DNA origin-binding and annealing protein physical 1 1 1 Affinity Capture-Western
SIZ1 YDR409W SUMO E3 ligase physical 1 1 1 Affinity Capture-MS
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
MMS22 YLR320W Subunit of E3 ubiquitin ligase complex involved in replication repair physical 1 1 1 Affinity Capture-MS
ISW1 YBR245C ATPase subunit of imitation-switch (ISWI) class chromatin remodelers physical 1 1 1 Affinity Capture-RNA
MCM6 YGL201C Protein involved in DNA replication physical 1 1 1 Affinity Capture-Western
POL1 YNL102W Catalytic subunit of the DNA polymerase I alpha-primase complex physical 1 1 1 Affinity Capture-Western
MMS21 YEL019C Highly conserved SUMO E3 ligase subunit of SMC5-SMC6 complex physical 1 1 1 Affinity Capture-Western
SMC5 YOL034W Subunit of the SMC5-SMC6 complex physical 1 1 1 Affinity Capture-Western
SEN1 YLR430W ATP-dependent 5' to 3' RNA/DNA and DNA helicase physical 1 1 1 Affinity Capture-Western
PAP2 YOL115W Non-canonical poly(A) polymerase genetic 1 1 1 Dosage Rescue
MCM10 YIL150C Essential chromatin-associated protein genetic 1 1 1 Synthetic Growth Defect
MSH6 YDR097C Protein required for mismatch repair in mitosis and meiosis genetic 1 1 1 Phenotypic Enhancement
REV3 YPL167C Catalytic subunit of DNA polymerase zeta genetic 1 1 1 Phenotypic Suppression
POL30 YBR088C Proliferating cell nuclear antigen (PCNA) genetic 1 1 1 Phenotypic Suppression
SMC3 YJL074C Subunit of the multiprotein cohesin complex genetic 1 1 1 Synthetic Lethality
TTI2 YJR136C Subunit of the ASTRA complex, involved in chromatin remodeling genetic 1 1 1 Negative Genetic
NRM1 YNR009W Transcriptional co-repressor of MBF-regulated gene expression genetic 1 1 1 Synthetic Rescue
GLE2 YER107C RNA export factor associated with the nuclear pore complex (NPC) genetic 1 1 1 Synthetic Growth Defect
RNH1 YMR234W Ribonuclease H1 genetic 1 1 1 Dosage Rescue
HRQ1 YDR291W 3'-5' DNA helicase of the conserved RecQ family genetic 1 1 1 Negative Genetic
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 1 1 1 Negative Genetic
ARP8 YOR141C Nuclear actin-related protein involved in chromatin remodeling genetic 1 1 1 Negative Genetic
DDC1 YPL194W DNA damage checkpoint protein genetic 1 1 1 Synthetic Lethality
DPB11 YJL090C DNA replication initiation protein physical 1 1 1 Two-hybrid
CSM3 YMR048W Replication fork associated factor physical 1 1 1 Affinity Capture-Western
CTF8 YHR191C Subunit of a complex with Ctf18p physical 1 1 1 Affinity Capture-MS
CBS1 YDL069C Mitochondrial translational activator of the COB mRNA physical 1 1 1 Affinity Capture-MS