Standard name Systematic name Name description Description
POL2 YNL262W Catalytic subunit of DNA polymerase (II) epsilon Catalytic subunit of DNA polymerase (II) epsilon; a chromosomal DNA replication polymerase that exhibits processivity and proofreading exonuclease activity; participates in leading-strand synthesis during DNA replication; also involved in DNA synthesis during DNA repair; interacts extensively with Mrc1p
Visualize the interactome of POL2
Links to external databases:
SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)
G1/S 46

CYCLoPs localization & abundance

WT1 WT2 WT3
Nucleus 0.965 0.906 0.945
Mito NaN 0.154 0.189

GFP localization & abundance

GFP localization GFP abundance
cytoplasm, nucleus 1970

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
POL2 8 1 0 5 5

Enzyme information

Catalyzed reactions in Yeast8

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
DPB2 YPR175W Second largest subunit of DNA polymerase II (DNA polymerase epsilon) physical 33 7 24 Affinity Capture-MS, Affinity Capture-Western, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Co-purification, Co-purification, Co-fractionation, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Co-crystal Structure, Affinity Capture-Western, Co-purification, Two-hybrid, Two-hybrid, Two-hybrid, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Two-hybrid, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western
RNH201 YNL072W Ribonuclease H2 catalytic subunit genetic 18 5 13 Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Rescue, Phenotypic Suppression, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Lethality, Synthetic Growth Defect, Phenotypic Suppression, Synthetic Lethality
DPB3 YBR278W Third-largest subunit of DNA polymerase II (DNA polymerase epsilon) physical 15 6 14 Affinity Capture-MS, Affinity Capture-Western, Two-hybrid, Two-hybrid, Affinity Capture-MS, Co-purification, Co-purification, Co-purification, Co-fractionation, Affinity Capture-MS, Co-purification, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex
DPB4 YDR121W Subunit of DNA pol epsilon and of ISW2 chromatin accessibility complex physical 15 6 14 Affinity Capture-Western, Affinity Capture-Western, Two-hybrid, Affinity Capture-Western, Affinity Capture-MS, Co-purification, Co-purification, Co-purification, Co-fractionation, Affinity Capture-MS, Affinity Capture-MS, Co-purification, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex
CTF18 YMR078C Subunit of a complex with Ctf8p physical 9 4 6 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Two-hybrid, Reconstituted Complex, Reconstituted Complex, Affinity Capture-Western, Two-hybrid
DPB2 YPR175W Second largest subunit of DNA polymerase II (DNA polymerase epsilon) genetic 8 4 7 Dosage Rescue, Synthetic Lethality, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Lethality
TOP1 YOL006C Topoisomerase I genetic 8 3 7 Synthetic Rescue, Phenotypic Suppression, Synthetic Rescue, Phenotypic Suppression, Phenotypic Enhancement, Synthetic Rescue, Phenotypic Suppression, Synthetic Rescue
POL3 YDL102W Catalytic subunit of DNA polymerase delta genetic 7 5 7 Synthetic Lethality, Phenotypic Enhancement, Synthetic Growth Defect, Negative Genetic, Phenotypic Suppression, Phenotypic Enhancement, Phenotypic Enhancement
MSH2 YOL090W Protein that binds to DNA mismatches genetic 7 3 6 Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Suppression, Synthetic Lethality, Phenotypic Enhancement, Phenotypic Enhancement
MSH6 YDR097C Protein required for mismatch repair in mitosis and meiosis genetic 7 3 6 Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Lethality, Phenotypic Enhancement, Phenotypic Enhancement
EXO1 YOR033C 5'-3' exonuclease and flap-endonuclease genetic 6 2 6 Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Rescue
DPB11 YJL090C DNA replication initiation protein genetic 6 4 5 Dosage Rescue, Synthetic Lethality, Dosage Rescue, Synthetic Growth Defect, Negative Genetic, Dosage Rescue
PSF1 YDR013W Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) genetic 5 4 5 Dosage Rescue, Phenotypic Enhancement, Synthetic Growth Defect, Negative Genetic, Phenotypic Enhancement
REV3 YPL167C Catalytic subunit of DNA polymerase zeta genetic 5 1 5 Phenotypic Suppression, Phenotypic Suppression, Phenotypic Suppression, Phenotypic Suppression, Phenotypic Suppression
MRC1 YCL061C S-phase checkpoint protein required for DNA replication physical 5 2 2 Two-hybrid, Two-hybrid, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western
DPB4 YDR121W Subunit of DNA pol epsilon and of ISW2 chromatin accessibility complex genetic 4 4 4 Dosage Rescue, Synthetic Lethality, Phenotypic Enhancement, Negative Genetic
SLD5 YDR489W Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) physical 4 3 4 Affinity Capture-Western, Affinity Capture-Western, Co-purification, Affinity Capture-MS
RAD24 YER173W Checkpoint protein genetic 4 3 4 Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Phenotypic Enhancement
POL32 YJR043C Third subunit of DNA polymerase delta genetic 4 3 4 Synthetic Growth Defect, Negative Genetic, Synthetic Lethality, Synthetic Lethality
RAD52 YML032C Protein involved in homologous recombination genetic 4 3 4 Synthetic Growth Defect, Negative Genetic, Synthetic Lethality, Negative Genetic
MRE11 YMR224C Nuclease subunit of the MRX complex with Rad50p and Xrs2p genetic 4 4 3 Synthetic Growth Defect, Phenotypic Enhancement, Negative Genetic, Synthetic Lethality
HST3 YOR025W Sirtuin, histone H3 deacetylase genetic 4 4 3 Synthetic Growth Defect, Synthetic Lethality, Phenotypic Enhancement, Negative Genetic
MRC1 YCL061C S-phase checkpoint protein required for DNA replication genetic 4 4 3 Synthetic Lethality, Dosage Rescue, Synthetic Growth Defect, Negative Genetic
PMS1 YNL082W ATP-binding protein required for mismatch repair genetic 4 3 3 Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Lethality, Phenotypic Enhancement
DUN1 YDL101C Cell-cycle checkpoint S/T protein kinase genetic 4 3 2 Synthetic Lethality, Phenotypic Suppression, Synthetic Rescue, Phenotypic Suppression
DPB3 YBR278W Third-largest subunit of DNA polymerase II (DNA polymerase epsilon) genetic 3 3 3 Dosage Rescue, Synthetic Growth Defect, Negative Genetic
RRM3 YHR031C DNA helicase involved in rDNA replication and Ty1 transposition genetic 3 3 3 Synthetic Growth Defect, Negative Genetic, Phenotypic Enhancement
RAD9 YDR217C DNA damage-dependent checkpoint protein genetic 3 3 3 Synthetic Growth Defect, Negative Genetic, Phenotypic Enhancement
RNH1 YMR234W Ribonuclease H1 genetic 3 2 3 Synthetic Lethality, Synthetic Lethality, Dosage Rescue
DPB11 YJL090C DNA replication initiation protein physical 3 2 3 Affinity Capture-Western, Two-hybrid, Affinity Capture-Western
MCM4 YPR019W Essential helicase component of heterohexameric MCM2-7 complexes physical 3 2 3 Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western
CTF18 YMR078C Subunit of a complex with Ctf8p genetic 3 3 2 Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Lethality
TRF5 YNL299W Non-canonical poly(A) polymerase physical 3 2 1 Affinity Capture-Western, Two-hybrid, Two-hybrid
ARP4 YJL081C Nuclear actin-related protein involved in chromatin remodeling genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
BRE1 YDL074C E3 ubiquitin ligase genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
LSM1 YJL124C Lsm (Like Sm) protein genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
PAT1 YCR077C Deadenylation-dependent mRNA-decapping factor genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
ASF1 YJL115W Nucleosome assembly factor genetic 2 2 2 Phenotypic Suppression, Synthetic Growth Defect
CDC14 YFR028C Protein phosphatase required for mitotic exit genetic 2 2 2 Synthetic Lethality, Negative Genetic
CDC45 YLR103C DNA replication initiation factor physical 2 2 2 Co-purification, Affinity Capture-Western
HDA1 YNL021W Catalytic subunit of class II HDA1 histone deacetylase complex genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
HTB2 YBL002W Histone H2B physical 2 2 2 Affinity Capture-MS, Affinity Capture-Western
MSH3 YCR092C Mismatch repair protein genetic 2 2 2 Phenotypic Enhancement, Synthetic Lethality
IES5 YER092W Non-essential INO80 chromatin remodeling complex subunit genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
PRI1 YIR008C Subunit of DNA primase physical 2 2 2 Reconstituted Complex, Co-purification
SLD2 YKL108W Single-stranded DNA origin-binding and annealing protein physical 2 2 2 Reconstituted Complex, Affinity Capture-Western
SEN1 YLR430W ATP-dependent 5' to 3' RNA/DNA and DNA helicase genetic 2 2 2 Negative Genetic, Synthetic Lethality
RFA1 YAR007C Subunit of heterotrimeric Replication Protein A (RPA) genetic 2 2 2 Synthetic Lethality, Negative Genetic
SRS2 YJL092W DNA helicase and DNA-dependent ATPase genetic 2 2 2 Synthetic Lethality, Synthetic Growth Defect
PPH21 YDL134C Catalytic subunit of protein phosphatase 2A, PP2A genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
PSF2 YJL072C Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
RAD17 YOR368W Checkpoint protein genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
RIM8 YGL045W Protein involved in proteolytic activation of Rim101p genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
SPN1 YPR133C Protein involved in RNA polymerase II transcription genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
SWC5 YBR231C Component of the SWR1 complex genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
VID22 YLR373C G-quadruplex (G4) DNA binding protein genetic 2 2 2 Synthetic Growth Defect, Positive Genetic
VIP1 YLR410W Bifunctional inositol pyrophosphate kinase and phosphatase genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
VPS71 YML041C Nucleosome-binding component of the SWR1 complex genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
XRS2 YDR369C FHA domain-containing component of the Mre11 complex genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
RTG2 YGL252C Sensor of mitochondrial dysfunction genetic 2 2 2 Synthetic Rescue, Negative Genetic
SDS3 YIL084C Component of the Rpd3L histone deacetylase complex genetic 2 2 2 Synthetic Rescue, Positive Genetic
SWI4 YER111C DNA binding component of the SBF complex (Swi4p-Swi6p) genetic 2 2 2 Synthetic Rescue, Positive Genetic
TAF12 YDR145W Subunit (61/68 kDa) of TFIID and SAGA complexes genetic 2 2 2 Synthetic Rescue, Negative Genetic
RAD51 YER095W Strand exchange protein genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
CDC6 YJL194W Essential ATP-binding protein required for DNA replication genetic 2 2 2 Negative Genetic, Positive Genetic
LTE1 YAL024C Protein similar to GDP/GTP exchange factors genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
MCM2 YBL023C Protein involved in DNA replication physical 2 2 2 Affinity Capture-MS, Affinity Capture-Western
MMS2 YGL087C Ubiquitin-conjugating enzyme variant genetic 2 2 2 Synthetic Lethality, Synthetic Rescue
CHK1 YBR274W Serine/threonine kinase and DNA damage checkpoint effector genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
DDC1 YPL194W DNA damage checkpoint protein genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
DIA2 YOR080W Origin-binding F-box protein genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
CTF4 YPR135W Chromatin-associated protein genetic 2 2 2 Negative Genetic, Synthetic Lethality
DBF2 YGR092W Ser/Thr kinase involved in transcription and stress response genetic 2 2 2 Synthetic Rescue, Negative Genetic
PML1 YLR016C Subunit of the RES complex genetic 2 2 2 Synthetic Rescue, Negative Genetic
IPK1 YDR315C Inositol 1,3,4,5,6-pentakisphosphate 2-kinase genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
CSM3 YMR048W Replication fork associated factor genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
AIM4 YBR194W Protein proposed to be associated with the nuclear pore complex genetic 2 2 2 Synthetic Growth Defect, Positive Genetic
CHL1 YPL008W Probable DNA helicase genetic 2 2 2 Negative Genetic, Synthetic Lethality
CDC21 YOR074C Thymidylate synthase genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
ARP6 YLR085C Actin-related protein that binds nucleosomes genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
CLB5 YPR120C B-type cyclin involved in DNA replication during S phase genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
CTF8 YHR191C Subunit of a complex with Ctf18p genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
GYP1 YOR070C Cis-golgi GTPase-activating protein (GAP) for yeast Rabs genetic 2 2 2 Synthetic Growth Defect, Positive Genetic
NUP188 YML103C Subunit of the inner ring of the nuclear pore complex (NPC) genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
BTS1 YPL069C Geranylgeranyl diphosphate synthase (GGPPS) genetic 2 2 2 Synthetic Rescue, Positive Genetic
DCC1 YCL016C Subunit of a complex with Ctf8p and Ctf18p physical 2 2 2 Affinity Capture-Western, Reconstituted Complex
DCC1 YCL016C Subunit of a complex with Ctf8p and Ctf18p genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
GCS1 YDL226C ADP-ribosylation factor GTPase activating protein (ARF GAP) genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
ARV1 YLR242C Cortical ER protein genetic 2 2 2 Synthetic Rescue, Positive Genetic
HST4 YDR191W NAD(+)-dependent protein deacetylase genetic 2 2 2 Synthetic Lethality, Phenotypic Enhancement
LGE1 YPL055C Protein involved in histone H2B ubiquitination genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
NPR3 YHL023C Subunit of the Iml1p/SEACIT complex genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
CDC33 YOL139C Translation initiation factor eIF4E physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
TIF4631 YGR162W Translation initiation factor eIF4G and scaffold protein physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
PUF3 YLL013C Protein of the mitochondrial outer surface physical 2 1 2 Affinity Capture-RNA, Affinity Capture-RNA
RAD27 YKL113C 5' to 3' exonuclease, 5' flap endonuclease genetic 2 1 2 Phenotypic Enhancement, Phenotypic Enhancement
POL30 YBR088C Proliferating cell nuclear antigen (PCNA) genetic 2 1 2 Phenotypic Suppression, Phenotypic Suppression
MCM3 YEL032W Protein involved in DNA replication physical 2 1 2 Affinity Capture-Western, Affinity Capture-Western
MMS21 YEL019C Highly conserved SUMO E3 ligase subunit of SMC5-SMC6 complex physical 2 2 1 Affinity Capture-Western, Biochemical Activity
TRF5 YNL299W Non-canonical poly(A) polymerase genetic 2 2 1 Synthetic Growth Defect, Synthetic Lethality
SMC1 YFL008W Subunit of the multiprotein cohesin complex genetic 2 2 1 Synthetic Growth Defect, Synthetic Lethality
RTT107 YHR154W BRCA1 C-terminal domain protein needed for recovery from DNA damage physical 2 2 1 Affinity Capture-Western, Two-hybrid
RNR4 YGR180C Ribonucleotide-diphosphate reductase (RNR) small subunit genetic 2 2 1 Phenotypic Enhancement, Phenotypic Suppression
SGT1 YOR057W Cochaperone protein genetic 2 2 1 Positive Genetic, Negative Genetic
PAP2 YOL115W Non-canonical poly(A) polymerase physical 2 2 1 Affinity Capture-Western, Two-hybrid
PAP2 YOL115W Non-canonical poly(A) polymerase genetic 2 2 1 Dosage Rescue, Synthetic Growth Defect
HNT3 YOR258W DNA 5' AMP hydrolase involved in DNA repair genetic 2 2 1 Synthetic Growth Defect, Phenotypic Enhancement
HSC82 YMR186W Cytoplasmic chaperone of the Hsp90 family physical 2 1 1 Affinity Capture-MS, Affinity Capture-MS
SFP1 YLR403W Regulates transcription of ribosomal protein and biogenesis genes regulation 1 1 1 DNA to cDNA expression microarray evidence
STP1 YDR463W Transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
REB1 YBR049C RNA polymerase I enhancer binding protein regulation 1 1 1 chromatin immunoprecipitation-chip evidence
YAP5 YIR018W Basic leucine zipper (bZIP) iron-sensing transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
UGA3 YDL170W Transcriptional activator for GABA-dependent induction of GABA genes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SMC5 YOL034W Subunit of the SMC5-SMC6 complex regulation 1 1 1 qualitative western immunoblotting evidence
SMC6 YLR383W Subunit of the SMC5-SMC6 complex regulation 1 1 1 qualitative western immunoblotting evidence
CDC73 YLR418C Component of the Paf1p complex genetic 1 1 1 Synthetic Lethality
CHD1 YER164W Chromatin remodeler that regulates various aspects of transcription genetic 1 1 1 Negative Genetic
DSN1 YIR010W Essential component of the outer kinetochore MIND complex physical 1 1 1 Affinity Capture-MS
CBF5 YLR175W Pseudouridine synthase catalytic subunit of box H/ACA snoRNPs physical 1 1 1 Affinity Capture-MS
POB3 YML069W Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) physical 1 1 1 Affinity Capture-Western
CKA1 YIL035C Alpha catalytic subunit of casein kinase 2 (CK2) physical 1 1 1 Affinity Capture-MS
CKB1 YGL019W Beta regulatory subunit of casein kinase 2 (CK2) genetic 1 1 1 Synthetic Growth Defect
CKB2 YOR039W Beta' regulatory subunit of casein kinase 2 (CK2) genetic 1 1 1 Synthetic Growth Defect
NSE3 YDR288W Component of the SMC5-SMC6 complex genetic 1 1 1 Negative Genetic
GLC7 YER133W Type 1 S/T protein phosphatase (PP1) catalytic subunit physical 1 1 1 Affinity Capture-MS
ESA1 YOR244W Catalytic subunit of the histone acetyltransferase complex (NuA4) genetic 1 1 1 Negative Genetic
BRX1 YOL077C Nucleolar protein genetic 1 1 1 Synthetic Rescue
NOP4 YPL043W Nucleolar protein genetic 1 1 1 Synthetic Growth Defect
PLB1 YMR008C Phospholipase B (lysophospholipase) involved in lipid metabolism genetic 1 1 1 Synthetic Rescue
PFK27 YOL136C 6-phosphofructo-2-kinase genetic 1 1 1 Negative Genetic
NSE4 YDL105W Component of the SMC5-SMC6 complex genetic 1 1 1 Negative Genetic
MRT4 YKL009W Protein involved in mRNA turnover and ribosome assembly genetic 1 1 1 Synthetic Rescue
MES1 YGR264C Methionyl-tRNA synthetase genetic 1 1 1 Negative Genetic
DBP3 YGL078C RNA-Dependent ATPase, member of DExD/H-box family genetic 1 1 1 Synthetic Rescue
GAR1 YHR089C Protein component of the H/ACA snoRNP pseudouridylase complex physical 1 1 1 Affinity Capture-MS
NOP56 YLR197W Essential evolutionarily-conserved nucleolar protein genetic 1 1 1 Synthetic Rescue
NOP1 YDL014W Histone glutamine methyltransferase, modifies H2A at Q105 in nucleolus genetic 1 1 1 Synthetic Rescue
CDC33 YOL139C Translation initiation factor eIF4E genetic 1 1 1 Synthetic Growth Defect
LRP1 YHR081W Nuclear exosome-associated nucleic acid binding protein genetic 1 1 1 Positive Genetic
DST1 YGL043W General transcription elongation factor TFIIS genetic 1 1 1 Synthetic Growth Defect
HCR1 YLR192C eIF3j component of translation initiation factor 3 (eIF3) genetic 1 1 1 Synthetic Growth Defect
ACT1 YFL039C Actin, structural protein in cytoskeleton genetic 1 1 1 Negative Genetic
KAP95 YLR347C Karyopherin beta genetic 1 1 1 Negative Genetic
CFT2 YLR115W Subunit of the mRNA cleavage and polyadenlylation factor (CPF) genetic 1 1 1 Positive Genetic
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-RNA
ARC18 YLR370C Subunit of the ARP2/3 complex genetic 1 1 1 Synthetic Growth Defect
BEM1 YBR200W Protein containing SH3-domains genetic 1 1 1 Synthetic Growth Defect
BET3 YKR068C Core component of transport protein particle (TRAPP) complexes I-III genetic 1 1 1 Synthetic Growth Defect
ASC1 YMR116C G-protein beta subunit and guanine dissociation inhibitor for Gpa2p physical 1 1 1 Affinity Capture-MS
ASC1 YMR116C G-protein beta subunit and guanine dissociation inhibitor for Gpa2p genetic 1 1 1 Positive Genetic
CAF40 YNL288W Component of the CCR4-NOT transcriptional complex genetic 1 1 1 Synthetic Growth Defect
CDC24 YAL041W Guanine nucleotide exchange factor (GEF) for Cdc42p genetic 1 1 1 Negative Genetic
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit physical 1 1 1 Biochemical Activity
CDC45 YLR103C DNA replication initiation factor genetic 1 1 1 Negative Genetic
BUD31 YCR063W Component of the SF3b subcomplex of the U2 snRNP genetic 1 1 1 Negative Genetic
CKS1 YBR135W Cyclin-dependent protein kinase regulatory subunit and adaptor genetic 1 1 1 Negative Genetic
COP1 YDL145C Alpha subunit of COPI vesicle coatomer complex genetic 1 1 1 Negative Genetic
CTK1 YKL139W Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I) genetic 1 1 1 Positive Genetic
DNA2 YHR164C ATP-dependent 5'-flap endonuclease and DNA helicase genetic 1 1 1 Negative Genetic
CIA2 YHR122W Component of cytosolic iron-sulfur protein assembly (CIA) machinery genetic 1 1 1 Negative Genetic
ELP2 YGR200C Subunit of Elongator complex genetic 1 1 1 Negative Genetic
EAF3 YPR023C Component of the Rpd3S histone deacetylase complex genetic 1 1 1 Negative Genetic
FIP1 YJR093C Subunit of cleavage polyadenylation factor (CPF) genetic 1 1 1 Negative Genetic
FRS1 YLR060W Beta subunit of cytoplasmic phenylalanyl-tRNA synthetase genetic 1 1 1 Negative Genetic
GCN1 YGL195W Positive regulator of the Gcn2p kinase activity genetic 1 1 1 Synthetic Rescue
ERV25 YML012W Member of the p24 family involved in ER to Golgi transport genetic 1 1 1 Synthetic Rescue
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
HSM3 YBR272C Evolutionarily conserved 19S regulatory particle assembly-chaperone genetic 1 1 1 Phenotypic Suppression
IPP1 YBR011C Cytoplasmic inorganic pyrophosphatase (PPase) genetic 1 1 1 Synthetic Growth Defect
IOC3 YFR013W Subunit of the Isw1a complex genetic 1 1 1 Negative Genetic
ISW1 YBR245C ATPase subunit of imitation-switch (ISWI) class chromatin remodelers physical 1 1 1 Affinity Capture-RNA
ISW1 YBR245C ATPase subunit of imitation-switch (ISWI) class chromatin remodelers genetic 1 1 1 Negative Genetic
HSL1 YKL101W Nim1p-related protein kinase genetic 1 1 1 Negative Genetic
LAS17 YOR181W Actin assembly factor genetic 1 1 1 Negative Genetic
LSM7 YNL147W Lsm (Like Sm) protein genetic 1 1 1 Synthetic Growth Defect
MBP1 YDL056W Transcription factor genetic 1 1 1 Negative Genetic
MCD1 YDL003W Essential alpha-kleisin subunit of the cohesin complex genetic 1 1 1 Synthetic Growth Defect
MCM5 YLR274W Component of the Mcm2-7 hexameric helicase complex physical 1 1 1 Co-purification
MCM5 YLR274W Component of the Mcm2-7 hexameric helicase complex genetic 1 1 1 Negative Genetic
MED1 YPR070W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
FAB1 YFR019W 1-phosphatidylinositol-3-phosphate 5-kinase genetic 1 1 1 Negative Genetic
MLH1 YMR167W Protein required for mismatch repair in mitosis and meiosis genetic 1 1 1 Synthetic Lethality
HRR25 YPL204W Conserved casein kinase, monopolin subunit physical 1 1 1 Biochemical Activity
HRR25 YPL204W Conserved casein kinase, monopolin subunit genetic 1 1 1 Negative Genetic
HDA3 YPR179C Subunit of HDA1 histone deacetylase complex genetic 1 1 1 Synthetic Growth Defect
MSH2 YOL090W Protein that binds to DNA mismatches physical 1 1 1 Co-localization
MEC1 YBR136W Genome integrity checkpoint protein and PI kinase superfamily member genetic 1 1 1 Synthetic Rescue
MPH1 YIR002C 3'-5' DNA helicase involved in error-free bypass of DNA lesions physical 1 1 1 Affinity Capture-MS
HTZ1 YOL012C Histone variant H2AZ genetic 1 1 1 Synthetic Growth Defect
NBP35 YGL091C Essential cytoplasmic iron-sulfur cluster binding protein genetic 1 1 1 Negative Genetic
NCL1 YBL024W S-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase genetic 1 1 1 Negative Genetic
NHP10 YDL002C Non-essential INO80 chromatin remodeling complex subunit genetic 1 1 1 Synthetic Growth Defect
NPL4 YBR170C Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase genetic 1 1 1 Negative Genetic
NUP159 YIL115C FG-nucleoporin component of central core of the nuclear pore complex genetic 1 1 1 Negative Genetic
ORC1 YML065W Largest subunit of the origin recognition complex genetic 1 1 1 Negative Genetic
ORC2 YBR060C Subunit of the origin recognition complex (ORC) genetic 1 1 1 Negative Genetic
AFG2 YLR397C ATPase of the CDC48/PAS1/SEC18 (AAA) family, forms a hexameric complex genetic 1 1 1 Negative Genetic
GIM3 YNL153C Subunit of the heterohexameric cochaperone prefoldin complex genetic 1 1 1 Synthetic Growth Defect
PCF11 YDR228C mRNA 3' end processing factor genetic 1 1 1 Synthetic Rescue
PDB1 YBR221C E1 beta subunit of the pyruvate dehydrogenase (PDH) complex genetic 1 1 1 Negative Genetic
POL1 YNL102W Catalytic subunit of the DNA polymerase I alpha-primase complex physical 1 1 1 Reconstituted Complex
POL1 YNL102W Catalytic subunit of the DNA polymerase I alpha-primase complex genetic 1 1 1 Phenotypic Enhancement
GLE2 YER107C RNA export factor associated with the nuclear pore complex (NPC) genetic 1 1 1 Synthetic Growth Defect
LEA1 YPL213W Component of U2 snRNP complex genetic 1 1 1 Synthetic Growth Defect
INO4 YOL108C Transcription factor involved in phospholipid synthesis genetic 1 1 1 Negative Genetic
MDS3 YGL197W Putative component of the TOR regulatory pathway genetic 1 1 1 Synthetic Rescue
PUB1 YNL016W Poly (A)+ RNA-binding protein physical 1 1 1 Affinity Capture-MS
SPT5 YML010W Spt4p/5p (DSIF) transcription elongation factor complex subunit physical 1 1 1 Affinity Capture-MS
SMC1 YFL008W Subunit of the multiprotein cohesin complex physical 1 1 1 Two-hybrid
POL2 YNL262W Catalytic subunit of DNA polymerase (II) epsilon physical 1 1 1 Two-hybrid
PRI2 YKL045W Subunit of DNA primase physical 1 1 1 Reconstituted Complex
PRI2 YKL045W Subunit of DNA primase genetic 1 1 1 Negative Genetic
TDH2 YJR009C Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), isozyme 2 physical 1 1 1 Affinity Capture-MS
STM1 YLR150W Protein required for optimal translation under nutrient stress physical 1 1 1 Affinity Capture-MS
RRM3 YHR031C DNA helicase involved in rDNA replication and Ty1 transposition physical 1 1 1 Affinity Capture-Western
SLD5 YDR489W Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) genetic 1 1 1 Negative Genetic
SBP1 YHL034C Protein that binds eIF4G and has a role in repression of translation physical 1 1 1 Affinity Capture-RNA
SIZ1 YDR409W SUMO E3 ligase physical 1 1 1 Affinity Capture-MS
SIZ1 YDR409W SUMO E3 ligase genetic 1 1 1 Phenotypic Suppression
ULP2 YIL031W Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins physical 1 1 1 Affinity Capture-MS
SPT10 YJL127C Histone H3 acetylase with a role in transcriptional regulation physical 1 1 1 Affinity Capture-MS
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
SLD2 YKL108W Single-stranded DNA origin-binding and annealing protein genetic 1 1 1 Dosage Rescue
VAM6 YDL077C Guanine nucleotide exchange factor for the GTPase Gtr1p physical 1 1 1 Affinity Capture-MS
SPT16 YGL207W Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) physical 1 1 1 Affinity Capture-Western
RTT107 YHR154W BRCA1 C-terminal domain protein needed for recovery from DNA damage genetic 1 1 1 Synthetic Growth Defect
RPC82 YPR190C RNA polymerase III subunit C82 physical 1 1 1 Affinity Capture-MS
RAD26 YJR035W Protein involved in transcription-coupled nucleotide excision repair physical 1 1 1 Co-crystal Structure
SGV1 YPR161C Cyclin (Bur2p)-dependent protein kinase physical 1 1 1 Biochemical Activity
SGV1 YPR161C Cyclin (Bur2p)-dependent protein kinase genetic 1 1 1 Negative Genetic
YCK2 YNL154C Palmitoylated plasma membrane-bound casein kinase I (CK1) isoform physical 1 1 1 Biochemical Activity
YCK3 YER123W Palmitoylated vacuolar membrane-localized casein kinase I isoform physical 1 1 1 Biochemical Activity
RIM11 YMR139W Protein kinase physical 1 1 1 Biochemical Activity
SSK2 YNR031C MAP kinase kinase kinase of HOG1 mitogen-activated signaling pathway physical 1 1 1 Biochemical Activity
SLN1 YIL147C Transmembrane histidine phosphotransfer kinase and osmosensor physical 1 1 1 Biochemical Activity
RTT103 YDR289C Protein involved in transcription termination by RNA polymerase II physical 1 1 1 Reconstituted Complex
SPT6 YGR116W Nucleosome remodeling protein physical 1 1 1 Affinity Capture-Western
SET1 YHR119W Histone methyltransferase, subunit of the COMPASS (Set1C) complex physical 1 1 1 Affinity Capture-Western
SMC5 YOL034W Subunit of the SMC5-SMC6 complex physical 1 1 1 Affinity Capture-Western
SMT3 YDR510W Ubiquitin-like protein of the SUMO family physical 1 1 1 Two-hybrid
SMT3 YDR510W Ubiquitin-like protein of the SUMO family genetic 1 1 1 Negative Genetic
RPS0A YGR214W Ribosomal 40S subunit protein S0A physical 1 1 1 Affinity Capture-MS
RPS10A YOR293W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS10A YOR293W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Synthetic Rescue
RPS12 YOR369C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS13 YDR064W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPL26A YLR344W Ribosomal 60S subunit protein L26A physical 1 1 1 Affinity Capture-MS
RPS3 YNL178W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
SEN1 YLR430W ATP-dependent 5' to 3' RNA/DNA and DNA helicase physical 1 1 1 Affinity Capture-Western
RAD53 YPL153C DNA damage response kinase physical 1 1 1 Biochemical Activity
RAD53 YPL153C DNA damage response kinase genetic 1 1 1 Synthetic Rescue
RFC2 YJR068W Subunit of heteropentameric Replication factor C (RF-C) genetic 1 1 1 Synthetic Lethality
POL4 YCR014C DNA polymerase IV genetic 1 1 1 Phenotypic Enhancement
PSF3 YOL146W Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) genetic 1 1 1 Dosage Rescue
TTI1 YKL033W Subunit of the ASTRA complex, involved in chromatin remodeling genetic 1 1 1 Positive Genetic
TTI2 YJR136C Subunit of the ASTRA complex, involved in chromatin remodeling genetic 1 1 1 Negative Genetic
RNH202 YDR279W Ribonuclease H2 subunit genetic 1 1 1 Synthetic Lethality
PRE9 YGR135W Alpha 3 subunit of the 20S proteasome genetic 1 1 1 Synthetic Growth Defect
RAD50 YNL250W Subunit of MRX complex with Mre11p and Xrs2p genetic 1 1 1 Synthetic Growth Defect
RAD57 YDR004W Protein that stimulates strand exchange genetic 1 1 1 Synthetic Growth Defect
RIM101 YHL027W Cys2His2 zinc-finger transcriptional repressor genetic 1 1 1 Synthetic Growth Defect
RIM13 YMR154C Calpain-like cysteine protease genetic 1 1 1 Synthetic Growth Defect
RIM21 YNL294C pH sensor molecule, component of the RIM101 pathway genetic 1 1 1 Synthetic Growth Defect
RIM9 YMR063W Plasma membrane protein of unknown function genetic 1 1 1 Synthetic Growth Defect
RRD2 YPL152W Peptidyl-prolyl cis/trans-isomerase genetic 1 1 1 Synthetic Growth Defect
RRN9 YMR270C Protein involved in promoting high level transcription of rDNA genetic 1 1 1 Synthetic Growth Defect
RTF1 YGL244W Subunit of RNAPII-associated chromatin remodeling Paf1 complex genetic 1 1 1 Synthetic Growth Defect
RXT3 YDL076C Component of the Rpd3L histone deacetylase complex genetic 1 1 1 Synthetic Growth Defect
SAC3 YDR159W mRNA export factor genetic 1 1 1 Synthetic Growth Defect
SAD1 YFR005C Conserved zinc-finger domain protein involved in pre-mRNA splicing genetic 1 1 1 Synthetic Growth Defect
SAF1 YBR280C F-Box protein involved in proteasome-dependent degradation of Aah1p genetic 1 1 1 Synthetic Growth Defect
SAP190 YKR028W Protein that forms a complex with the Sit4p protein phosphatase genetic 1 1 1 Synthetic Growth Defect
SET3 YKR029C Defining member of the SET3 histone deacetylase complex genetic 1 1 1 Synthetic Growth Defect
SGF29 YCL010C Component of the HAT/Core module of the SAGA, SLIK, and ADA complexes genetic 1 1 1 Synthetic Growth Defect
SHE1 YBL031W Mitotic spindle protein genetic 1 1 1 Synthetic Growth Defect
SHE4 YOR035C Protein containing a UCS (UNC-45/CRO1/SHE4) domain genetic 1 1 1 Synthetic Growth Defect
SHR3 YDL212W Endoplasmic reticulum packaging chaperone genetic 1 1 1 Synthetic Growth Defect
SIF2 YBR103W WD40 repeat-containing subunit of Set3C histone deacetylase complex genetic 1 1 1 Synthetic Growth Defect
SIR1 YKR101W Protein involved in silencing at mating-type loci HML and HMR genetic 1 1 1 Synthetic Growth Defect
SIW14 YNL032W Inositol phosphatase involved in inositol pyrophosphate metabolism genetic 1 1 1 Synthetic Growth Defect
SLT2 YHR030C Serine/threonine MAP kinase genetic 1 1 1 Synthetic Growth Defect
SMI1 YGR229C Protein involved in the regulation of cell wall synthesis genetic 1 1 1 Synthetic Growth Defect
SNT1 YCR033W Set3C histone deacetylase scaffold genetic 1 1 1 Synthetic Growth Defect
SNX3 YOR357C Sorting nexin for late-Golgi enzymes genetic 1 1 1 Synthetic Growth Defect
SOH1 YGL127C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Synthetic Growth Defect
SOK2 YMR016C Nuclear protein that negatively regulates pseudohyphal differentiation genetic 1 1 1 Synthetic Growth Defect
SRB2 YHR041C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Synthetic Growth Defect
SRN2 YLR119W Component of the ESCRT-I complex genetic 1 1 1 Synthetic Growth Defect
SSO2 YMR183C Plasma membrane t-SNARE genetic 1 1 1 Synthetic Growth Defect
SWD1 YAR003W Subunit of the COMPASS (Set1C) complex genetic 1 1 1 Synthetic Growth Defect
SWD3 YBR175W Essential subunit of the COMPASS (Set1C) complex genetic 1 1 1 Synthetic Growth Defect
SWF1 YDR126W Palmitoyltransferase that acts on transmembrane proteins genetic 1 1 1 Synthetic Growth Defect
SWR1 YDR334W Swi2/Snf2-related ATPase genetic 1 1 1 Synthetic Growth Defect
TCO89 YPL180W Subunit of TORC1 (Tor1p or Tor2p-Kog1p-Lst8p-Tco89p) genetic 1 1 1 Synthetic Growth Defect
TIF5 YPR041W Translation initiation factor eIF5 genetic 1 1 1 Synthetic Growth Defect
TIM50 YPL063W Essential component of the TIM23 complex genetic 1 1 1 Synthetic Growth Defect
TRR2 YHR106W Mitochondrial thioredoxin reductase genetic 1 1 1 Synthetic Growth Defect
TRS20 YBR254C Core component of transport protein particle (TRAPP) complexes I-III genetic 1 1 1 Synthetic Growth Defect
TRS85 YDR108W Component of transport protein particle (TRAPP) complex III genetic 1 1 1 Synthetic Growth Defect
TUM1 YOR251C Rhodanese domain sulfur transferase genetic 1 1 1 Synthetic Growth Defect
UBA4 YHR111W E1-like protein that activates Urm1p before urmylation genetic 1 1 1 Synthetic Growth Defect
UME6 YDR207C Rpd3L histone deacetylase complex subunit genetic 1 1 1 Synthetic Growth Defect
URM1 YIL008W Ubiquitin-like protein involved in thiolation of cytoplasmic tRNAs genetic 1 1 1 Synthetic Growth Defect
VAC8 YEL013W Vacuole-specific Myo2p receptor genetic 1 1 1 Synthetic Growth Defect
VAM10 YOR068C Protein involved in vacuole morphogenesis genetic 1 1 1 Synthetic Growth Defect
VHS3 YOR054C Negative regulatory subunit of protein phosphatase 1 Ppz1p genetic 1 1 1 Synthetic Growth Defect
VMS1 YDR049W Peptidyl-tRNA hydrolase that releases stalled peptides from ribosomes, genetic 1 1 1 Synthetic Growth Defect
VPS13 YLL040C Lipid transport protein involved in prospore membrane morphogenesis genetic 1 1 1 Synthetic Growth Defect
VPS17 YOR132W Subunit of the membrane-associated retromer complex genetic 1 1 1 Synthetic Growth Defect
VPS21 YOR089C Endosomal Rab family GTPase genetic 1 1 1 Synthetic Growth Defect
VPS29 YHR012W Subunit of the membrane-associated retromer complex genetic 1 1 1 Synthetic Growth Defect
VPS30 YPL120W Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II genetic 1 1 1 Synthetic Growth Defect
VPS5 YOR069W Nexin-1 homolog genetic 1 1 1 Synthetic Growth Defect
VPS55 YJR044C Late endosomal protein involved in late endosome to vacuole transport genetic 1 1 1 Synthetic Growth Defect
VPS60 YDR486C Protein involved in late endosome to vacuole transport genetic 1 1 1 Synthetic Growth Defect
VPS8 YAL002W Membrane-binding component of the CORVET complex genetic 1 1 1 Synthetic Growth Defect
XRN1 YGL173C Evolutionarily-conserved 5'-3' exonuclease genetic 1 1 1 Synthetic Growth Defect
YGR122W YGR122W Protein that may be involved in pH regulation genetic 1 1 1 Synthetic Growth Defect
YGR237C YGR237C Putative protein of unknown function genetic 1 1 1 Synthetic Growth Defect
YSC83 YHR017W Non-essential mitochondrial protein of unknown function genetic 1 1 1 Synthetic Growth Defect
PPT1 YGR123C Protein serine/threonine phosphatase genetic 1 1 1 Synthetic Rescue
PRE2 YPR103W Beta 5 subunit of the 20S proteasome genetic 1 1 1 Synthetic Rescue
PRP11 YDL043C Subunit of the SF3a splicing factor complex genetic 1 1 1 Synthetic Rescue
PRP38 YGR075C Unique component of the U4/U6.U5 tri-snRNP particle genetic 1 1 1 Synthetic Rescue
PUF6 YDR496C Pumilio-homology domain protein genetic 1 1 1 Synthetic Rescue
RAD10 YML095C Single-stranded DNA endonuclease (with Rad1p) genetic 1 1 1 Synthetic Rescue
RCK1 YGL158W Protein kinase involved in oxidative stress response genetic 1 1 1 Synthetic Rescue
RGR1 YLR071C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Synthetic Rescue
ULS1 YOR191W Swi2/Snf2-related translocase, SUMO-Targeted Ubiquitin Ligase (STUbL) genetic 1 1 1 Synthetic Rescue
RKM2 YDR198C Ribosomal protein lysine methyltransferase genetic 1 1 1 Synthetic Rescue
RPA43 YOR340C RNA polymerase I subunit A43 genetic 1 1 1 Synthetic Rescue
RPC17 YJL011C RNA polymerase III subunit C17 genetic 1 1 1 Synthetic Rescue
RPC19 YNL113W RNA polymerase subunit AC19 genetic 1 1 1 Synthetic Rescue
RPL13A YDL082W Ribosomal 60S subunit protein L13A genetic 1 1 1 Synthetic Rescue
RPL16A YIL133C Ribosomal 60S subunit protein L16A genetic 1 1 1 Synthetic Rescue
RPL23A YBL087C Ribosomal 60S subunit protein L23A genetic 1 1 1 Synthetic Rescue
RPL24B YGR148C Ribosomal 60S subunit protein L24B genetic 1 1 1 Synthetic Rescue
RPL29 YFR032C-A Ribosomal 60S subunit protein L29 genetic 1 1 1 Synthetic Rescue
RPL2A YFR031C-A Ribosomal 60S subunit protein L2A genetic 1 1 1 Synthetic Rescue
RPL35B YDL136W Ribosomal 60S subunit protein L35B genetic 1 1 1 Synthetic Rescue
RPL37B YDR500C Ribosomal 60S subunit protein L37B genetic 1 1 1 Synthetic Rescue
RPL9A YGL147C Ribosomal 60S subunit protein L9A genetic 1 1 1 Synthetic Rescue
RPN12 YFR052W Subunit of the 19S regulatory particle of the 26S proteasome lid genetic 1 1 1 Synthetic Rescue
RPN14 YGL004C Evolutionarily conserved 19S regulatory particle assembly-chaperone genetic 1 1 1 Synthetic Rescue
RPN6 YDL097C Essential, non-ATPase regulatory subunit of the 26S proteasome lid genetic 1 1 1 Synthetic Rescue
RPN7 YPR108W Essential non-ATPase regulatory subunit of the 26S proteasome genetic 1 1 1 Synthetic Rescue
RPP1B YDL130W Ribosomal protein P1 beta genetic 1 1 1 Synthetic Rescue
RPS17B YDR447C Ribosomal protein 51 (rp51) of the small (40s) subunit genetic 1 1 1 Synthetic Rescue
RPT3 YDR394W ATPase of the 19S regulatory particle of the 26S proteasome genetic 1 1 1 Synthetic Rescue
SAP4 YGL229C Protein required for function of the Sit4p protein phosphatase genetic 1 1 1 Synthetic Rescue
SCW11 YGL028C Cell wall protein with similarity to glucanases genetic 1 1 1 Synthetic Rescue
SEC20 YDR498C Membrane glycoprotein v-SNARE genetic 1 1 1 Synthetic Rescue
SGF73 YGL066W Subunit of DUBm module of SAGA and SLIK genetic 1 1 1 Synthetic Rescue
SIP5 YMR140W Protein of unknown function genetic 1 1 1 Synthetic Rescue
SLX9 YGR081C Protein required for pre-rRNA processing genetic 1 1 1 Synthetic Rescue
SNM1 YDR478W Ribonuclease MRP complex subunit genetic 1 1 1 Synthetic Rescue
SPO20 YMR017W Meiosis-specific subunit of the t-SNARE complex genetic 1 1 1 Synthetic Rescue
SPT21 YMR179W Protein with a role in transcriptional silencing genetic 1 1 1 Synthetic Rescue
SSF1 YHR066W Constituent of 66S pre-ribosomal particles genetic 1 1 1 Synthetic Rescue
SUP45 YBR143C Polypeptide release factor (eRF1) in translation termination genetic 1 1 1 Synthetic Rescue
TFA2 YKR062W TFIIE small subunit genetic 1 1 1 Synthetic Rescue
TFB4 YPR056W Subunit of TFIIH complex genetic 1 1 1 Synthetic Rescue
TIF6 YPR016C Constituent of 66S pre-ribosomal particles genetic 1 1 1 Synthetic Rescue
SUP35 YDR172W Translation termination factor eRF3 genetic 1 1 1 Positive Genetic
TRS23 YDR246W Core component of transport protein particle (TRAPP) complexes I-III genetic 1 1 1 Positive Genetic
SPC97 YHR172W Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex genetic 1 1 1 Positive Genetic
SPC24 YMR117C Component of the kinetochore-associated Ndc80 complex genetic 1 1 1 Positive Genetic
RDS3 YPR094W Component of the SF3b subcomplex of the U2 snRNP genetic 1 1 1 Positive Genetic
RXT2 YBR095C Component of the histone deacetylase Rpd3L complex genetic 1 1 1 Positive Genetic
TEF2 YBR118W Translational elongation factor EF-1 alpha genetic 1 1 1 Positive Genetic
SLX5 YDL013W Subunit of the Slx5-Slx8 SUMO-targeted Ub ligase (STUbL) complex genetic 1 1 1 Positive Genetic
RPN4 YDL020C Transcription factor that stimulates expression of proteasome genes genetic 1 1 1 Positive Genetic
RPP2B YDR382W Ribosomal protein P2 beta genetic 1 1 1 Positive Genetic
UBR1 YGR184C E3 ubiquitin ligase (N-recognin) genetic 1 1 1 Positive Genetic
VPS24 YKL041W One of four subunits of the ESCRT-III complex genetic 1 1 1 Positive Genetic
SPE1 YKL184W Ornithine decarboxylase genetic 1 1 1 Positive Genetic
RPS0B YLR048W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Positive Genetic
SIC1 YLR079W Cyclin-dependent kinase inhibitor (CKI) genetic 1 1 1 Positive Genetic
SIN3 YOL004W Component of both the Rpd3S and Rpd3L histone deacetylase complexes genetic 1 1 1 Positive Genetic
TOS7 YOL019W Protein involved in secretion and cell wall organization genetic 1 1 1 Positive Genetic
RFC5 YBR087W Subunit of heteropentameric Replication factor C (RF-C) genetic 1 1 1 Negative Genetic
TAF5 YBR198C Subunit (90 kDa) of TFIID and SAGA complexes genetic 1 1 1 Negative Genetic
TSC13 YDL015C Enoyl reductase genetic 1 1 1 Negative Genetic
UBC9 YDL064W SUMO-conjugating enzyme involved in the Smt3p conjugation pathway genetic 1 1 1 Negative Genetic
YRB1 YDR002W Ran GTPase binding protein genetic 1 1 1 Negative Genetic
SLU7 YDR088C RNA splicing factor genetic 1 1 1 Negative Genetic
TFB1 YDR311W Subunit of TFIIH and nucleotide excision repair factor 3 complexes genetic 1 1 1 Negative Genetic
PUP3 YER094C Beta 3 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
RSP5 YER125W NEDD4 family E3 ubiquitin ligase genetic 1 1 1 Negative Genetic
RNA15 YGL044C Component of the cleavage and polyadenylation factor I (CF I) genetic 1 1 1 Negative Genetic
SRM1 YGL097W Nucleotide exchange factor for Gsp1p genetic 1 1 1 Negative Genetic
SLD3 YGL113W Protein involved in the initiation of DNA replication genetic 1 1 1 Negative Genetic
TAF1 YGR274C TFIID subunit, involved in RNA pol II transcription initiation genetic 1 1 1 Negative Genetic
STS1 YIR011C Protein required for localizing proteasomes to the nucleus genetic 1 1 1 Negative Genetic
SMC3 YJL074C Subunit of the multiprotein cohesin complex genetic 1 1 1 Negative Genetic
POL31 YJR006W Subunit of DNA polymerase delta (polymerase III) genetic 1 1 1 Negative Genetic
UGP1 YKL035W UDP-glucose pyrophosphorylase (UGPase) genetic 1 1 1 Negative Genetic
TAF13 YML098W TFIID subunit (19 kDa) genetic 1 1 1 Negative Genetic
TAF8 YML114C TFIID subunit (65 kDa) genetic 1 1 1 Negative Genetic
RSC9 YML127W Component of the RSC chromatin remodeling complex genetic 1 1 1 Negative Genetic
TAF4 YMR005W TFIID subunit (48 kDa) genetic 1 1 1 Negative Genetic
RNA1 YMR235C GTPase activating protein (GAP) for Gsp1p genetic 1 1 1 Negative Genetic
RPC34 YNR003C RNA polymerase III subunit C34 genetic 1 1 1 Negative Genetic
RFC4 YOL094C Subunit of heteropentameric Replication factor C (RF-C) genetic 1 1 1 Negative Genetic
TOA1 YOR194C TFIIA large subunit genetic 1 1 1 Negative Genetic
PRT1 YOR361C eIF3b subunit of the eukaryotic translation initiation factor 3 (eIF3) genetic 1 1 1 Negative Genetic
SWC3 YAL011W Protein of unknown function genetic 1 1 1 Negative Genetic
RPL19B YBL027W Ribosomal 60S subunit protein L19B genetic 1 1 1 Negative Genetic
RPS8A YBL072C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
YBL081W YBL081W Non-essential protein of unknown function genetic 1 1 1 Negative Genetic
YBR238C YBR238C Mitochondrial membrane protein genetic 1 1 1 Negative Genetic
PTC6 YCR079W Mitochondrial type 2C protein phosphatase (PP2C) genetic 1 1 1 Negative Genetic
RPP1A YDL081C Ribosomal stalk protein P1 alpha genetic 1 1 1 Negative Genetic
PPH3 YDR075W Catalytic subunit of protein phosphatase PP4 complex genetic 1 1 1 Negative Genetic
RPA14 YDR156W RNA polymerase I subunit A14 genetic 1 1 1 Negative Genetic
RVS167 YDR388W Calmodulin-binding actin-associated protein genetic 1 1 1 Negative Genetic
VPS72 YDR485C Htz1p-binding component of the SWR1 complex genetic 1 1 1 Negative Genetic
SPT2 YER161C Protein involved in negative regulation of transcription genetic 1 1 1 Negative Genetic
SAE2 YGL175C Endonuclease required for telomere elongation genetic 1 1 1 Negative Genetic
RTT102 YGR275W Component of both the SWI/SNF and RSC chromatin remodeling complexes genetic 1 1 1 Negative Genetic
RPS27B YHR021C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
RPN10 YHR200W Proteasome polyubiquitin receptor genetic 1 1 1 Negative Genetic
RPS4B YHR203C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
YIA6 YIL006W Mitochondrial NAD+ transporter genetic 1 1 1 Negative Genetic
TED1 YIL039W GPI-glycan remodelase genetic 1 1 1 Negative Genetic
SET2 YJL168C Histone methyltransferase with a role in transcriptional elongation genetic 1 1 1 Negative Genetic
YKL069W YKL069W Methionine-R-sulfoxide reductase genetic 1 1 1 Negative Genetic
SAC1 YKL212W Phosphatidylinositol phosphate phosphatase genetic 1 1 1 Negative Genetic
RTT109 YLL002W Histone acetyltransferase genetic 1 1 1 Negative Genetic
POM34 YLR018C Subunit of the transmembrane ring of the nuclear pore complex (NPC) genetic 1 1 1 Negative Genetic
UBR2 YLR024C Cytoplasmic ubiquitin-protein ligase (E3) genetic 1 1 1 Negative Genetic
XDJ1 YLR090W Chaperone with a role in facilitating mitochondrial protein import genetic 1 1 1 Negative Genetic
SWI6 YLR182W Transcription cofactor genetic 1 1 1 Negative Genetic
TOP3 YLR234W DNA Topoisomerase III genetic 1 1 1 Negative Genetic
RPL38 YLR325C Ribosomal 60S subunit protein L38 genetic 1 1 1 Negative Genetic
VAC14 YLR386W Enzyme regulator genetic 1 1 1 Negative Genetic
STE23 YLR389C Metalloprotease genetic 1 1 1 Negative Genetic
SST2 YLR452C GTPase-activating protein for Gpa1p genetic 1 1 1 Negative Genetic
YPT7 YML001W Rab family GTPase genetic 1 1 1 Negative Genetic
RCO1 YMR075W Essential component of the Rpd3S histone deacetylase complex genetic 1 1 1 Negative Genetic
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 1 1 1 Negative Genetic
SCS7 YMR272C Sphingolipid alpha-hydroxylase genetic 1 1 1 Negative Genetic
YMR315W YMR315W Protein with NADP(H) oxidoreductase activity genetic 1 1 1 Negative Genetic
YMR316C-A YMR316C-A Protein of unknown function genetic 1 1 1 Negative Genetic
YOL029C YOL029C Putative protein of unknown function genetic 1 1 1 Negative Genetic
RTS1 YOR014W B-type regulatory subunit of protein phosphatase 2A (PP2A) genetic 1 1 1 Negative Genetic
WHI5 YOR083W Repressor of G1 transcription genetic 1 1 1 Negative Genetic
SYC1 YOR179C Subunit of the APT subcomplex of cleavage and polyadenylation factor genetic 1 1 1 Negative Genetic
RFM1 YOR279C Component of the Sum1p-Rfm1p-Hst1p complex genetic 1 1 1 Negative Genetic
YOR289W YOR289W Putative protein of unknown function genetic 1 1 1 Negative Genetic
RMI1 YPL024W Subunit of the RecQ (Sgs1p) - Topo III (Top3p) complex genetic 1 1 1 Negative Genetic
RPS6A YPL090C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
RPL43A YPR043W Ribosomal 60S subunit protein L43A genetic 1 1 1 Negative Genetic
RPS23B YPR132W Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
SML1 YML058W Ribonucleotide reductase inhibitor genetic 1 1 1 Synthetic Rescue
RTG3 YBL103C bHLH/Zip transcription factor for retrograde (RTG) and TOR pathways genetic 1 1 1 Negative Genetic
REB1 YBR049C RNA polymerase I enhancer binding protein genetic 1 1 1 Positive Genetic
RAD14 YMR201C Subunit of Nucleotide Excision Repair Factor 1 (NEF1) genetic 1 1 1 Positive Genetic
URA7 YBL039C Major CTP synthase isozyme (see also URA8) genetic 1 1 1 Phenotypic Enhancement
YKU70 YMR284W Subunit of the telomeric Ku complex (Yku70p-Yku80p) genetic 1 1 1 Phenotypic Suppression
RNR1 YER070W Major isoform of large subunit of ribonucleotide-diphosphate reductase genetic 1 1 1 Synthetic Growth Defect
BUD21 YOR078W Component of small ribosomal subunit (SSU) processosome genetic 1 1 1 Negative Genetic
HTA2 YBL003C Histone H2A physical 1 1 1 Affinity Capture-MS
PDC1 YLR044C Major of three pyruvate decarboxylase isozymes genetic 1 1 1 Synthetic Rescue
DEP1 YAL013W Component of the Rpd3L histone deacetylase complex genetic 1 1 1 Positive Genetic
MAF1 YDR005C Highly conserved negative regulator of RNA polymerase III genetic 1 1 1 Synthetic Rescue
NUP85 YJR042W Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) genetic 1 1 1 Negative Genetic
HOS2 YGL194C Histone deacetylase and subunit of Set3 and Rpd3L complexes genetic 1 1 1 Synthetic Growth Defect
CDC25 YLR310C Membrane bound guanine nucleotide exchange factor genetic 1 1 1 Positive Genetic
INP52 YNL106C Polyphosphatidylinositol phosphatase genetic 1 1 1 Synthetic Growth Defect
NEM1 YHR004C Probable catalytic subunit of Nem1p-Spo7p phosphatase holoenzyme genetic 1 1 1 Negative Genetic
HEM13 YDR044W Coproporphyrinogen III oxidase genetic 1 1 1 Synthetic Rescue
CCT6 YDR188W Subunit of the cytosolic chaperonin Cct ring complex genetic 1 1 1 Positive Genetic
MCM2 YBL023C Protein involved in DNA replication genetic 1 1 1 Negative Genetic
FLC2 YAL053W Putative calcium channel involved in calcium release under hypotonic genetic 1 1 1 Synthetic Rescue
BRE2 YLR015W Subunit of COMPASS (Set1C) complex genetic 1 1 1 Synthetic Growth Defect
GET3 YDL100C Guanine nucleotide exchange factor for Gpa1p genetic 1 1 1 Synthetic Growth Defect
LAP2 YNL045W Leucyl aminopeptidase yscIV with epoxide hydrolase activity genetic 1 1 1 Synthetic Growth Defect
CDC13 YDL220C Single stranded DNA-binding protein found at TG1-3 telomere G-tails genetic 1 1 1 Negative Genetic
LSP1 YPL004C Eisosome core component genetic 1 1 1 Synthetic Growth Defect
PHO84 YML123C High-affinity inorganic phosphate (Pi) transporter genetic 1 1 1 Negative Genetic
FIN1 YDR130C Spindle pole body-related intermediate filament protein genetic 1 1 1 Synthetic Rescue
NGL2 YMR285C Protein involved in 5.8S rRNA processing genetic 1 1 1 Synthetic Growth Defect
IRA2 YOL081W GTPase-activating protein genetic 1 1 1 Positive Genetic
PHO85 YPL031C Cyclin-dependent kinase physical 1 1 1 Biochemical Activity
CAF20 YOR276W Phosphoprotein of the mRNA cap-binding complex physical 1 1 1 Affinity Capture-RNA
BUB2 YMR055C Mitotic exit network regulator genetic 1 1 1 Synthetic Growth Defect
HTB1 YDR224C Histone H2B physical 1 1 1 Affinity Capture-Western
HTB1 YDR224C Histone H2B genetic 1 1 1 Synthetic Growth Defect
HIR3 YJR140C Subunit of the HIR complex genetic 1 1 1 Negative Genetic
GSP1 YLR293C Ran GTPase genetic 1 1 1 Negative Genetic
BFA1 YJR053W Subunit of a two-component GTPase-activating protein, Bfa1p-Bub2p genetic 1 1 1 Synthetic Growth Defect
CMK1 YFR014C Calmodulin-dependent protein kinase physical 1 1 1 Biochemical Activity
COF1 YLL050C Cofilin, involved in pH-dependent actin filament depolarization genetic 1 1 1 Negative Genetic
INM1 YHR046C Inositol monophosphatase physical 1 1 1 Affinity Capture-MS
MLH3 YPL164C Protein involved in DNA mismatch repair and meiotic recombination genetic 1 1 1 Synthetic Lethality
CDC20 YGL116W Activator of anaphase-promoting complex/cyclosome (APC/C) genetic 1 1 1 Negative Genetic
KAP122 YGL016W Karyopherin beta genetic 1 1 1 Negative Genetic
PDS1 YDR113C Securin genetic 1 1 1 Negative Genetic
CAT5 YOR125C Protein required for ubiquinone (Coenzyme Q) biosynthesis genetic 1 1 1 Synthetic Growth Defect
ETP1 YHL010C Protein of unknown function required for growth on ethanol genetic 1 1 1 Synthetic Growth Defect
HUL5 YGL141W Multiubiquitin chain assembly factor (E4) genetic 1 1 1 Synthetic Rescue
DNL4 YOR005C DNA ligase required for nonhomologous end-joining (NHEJ) genetic 1 1 1 Phenotypic Enhancement
PDX1 YGR193C E3-binding protein of the mitochondrial pyruvate dehydrogenase complex genetic 1 1 1 Synthetic Rescue
CDC15 YAR019C Hippo-like kinase of the Mitotic Exit Network genetic 1 1 1 Positive Genetic
HIR2 YOR038C Subunit of HIR nucleosome assembly complex genetic 1 1 1 Synthetic Growth Defect
HHT1 YBR010W Histone H3 physical 1 1 1 Affinity Capture-Western
HHT1 YBR010W Histone H3 genetic 1 1 1 Synthetic Rescue
CTF4 YPR135W Chromatin-associated protein physical 1 1 1 Affinity Capture-MS
ICP55 YER078C Mitochondrial aminopeptidase genetic 1 1 1 Synthetic Rescue
CLB2 YPR119W B-type cyclin involved in cell cycle progression genetic 1 1 1 Synthetic Growth Defect
NUP2 YLR335W Nucleoporin involved in nucleocytoplasmic transport genetic 1 1 1 Negative Genetic
ELG1 YOR144C Subunit of an alternative replication factor C complex genetic 1 1 1 Synthetic Lethality
NDE1 YMR145C Mitochondrial external NADH dehydrogenase genetic 1 1 1 Synthetic Rescue
FAL1 YDR021W Nucleolar protein required for maturation of 18S rRNA genetic 1 1 1 Negative Genetic
BTN2 YGR142W v-SNARE binding protein genetic 1 1 1 Synthetic Rescue
CIA1 YDR267C Component of cytosolic iron-sulfur protein assembly (CIA) machinery genetic 1 1 1 Synthetic Rescue
BUB3 YOR026W Kinetochore checkpoint WD40 repeat protein genetic 1 1 1 Negative Genetic
MMS4 YBR098W Subunit of structure-specific Mms4p-Mus81p endonuclease genetic 1 1 1 Negative Genetic
HOM2 YDR158W Aspartic beta semi-aldehyde dehydrogenase genetic 1 1 1 Synthetic Rescue
EXO70 YJL085W Subunit of the exocyst complex genetic 1 1 1 Positive Genetic
ERG11 YHR007C Lanosterol 14-alpha-demethylase genetic 1 1 1 Positive Genetic
NUP133 YKR082W Subunit of Nup84p subcomplex of nuclear pore complex (NPC) genetic 1 1 1 Synthetic Growth Defect
MMS22 YLR320W Subunit of E3 ubiquitin ligase complex involved in replication repair genetic 1 1 1 Synthetic Growth Defect
MLP2 YIL149C Myosin-like protein associated with the nuclear envelope genetic 1 1 1 Positive Genetic
DAD1 YDR016C Essential subunit of the Dam1 complex (aka DASH complex) genetic 1 1 1 Positive Genetic
BUD27 YFL023W Unconventional prefoldin protein involved in translation initiation genetic 1 1 1 Synthetic Growth Defect
ATG16 YMR159C Conserved protein involved in autophagy genetic 1 1 1 Synthetic Rescue
CSM1 YCR086W Nucleolar protein that mediates homolog segregation during meiosis I genetic 1 1 1 Negative Genetic
MCM10 YIL150C Essential chromatin-associated protein genetic 1 1 1 Synthetic Growth Defect
INO2 YDR123C Transcription factor genetic 1 1 1 Positive Genetic
MOB2 YFL034C-B Activator of Cbk1p kinase genetic 1 1 1 Negative Genetic
MSN5 YDR335W Karyopherin genetic 1 1 1 Positive Genetic
NUP57 YGR119C FG-nucleoporin component of central core of the nuclear pore complex genetic 1 1 1 Negative Genetic
MND2 YIR025W Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 1 1 1 Negative Genetic
PBY1 YBR094W Putative tubulin tyrosine ligase associated with P-bodies genetic 1 1 1 Negative Genetic
BAS1 YKR099W Myb-related transcription factor genetic 1 1 1 Positive Genetic
DAS2 YDR020C Putative protein of unknown function genetic 1 1 1 Synthetic Rescue
PIR5 YJL160C Putative protein of unknown function genetic 1 1 1 Negative Genetic
MGL2 YMR210W Monoacylglycerol and triacylglycerol lipase genetic 1 1 1 Negative Genetic
MDY2 YOL111C Protein involved in inserting tail-anchored proteins into ER membranes genetic 1 1 1 Positive Genetic
NST1 YNL091W Translational inhibitor and suppressor of proteasome-assembly defects genetic 1 1 1 Synthetic Growth Defect
FMP40 YPL222W Mitochondrial AMPylator in the pseudokinase selenoprotein-O family genetic 1 1 1 Negative Genetic
APC4 YDR118W Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 1 1 1 Synthetic Rescue
ELP3 YPL086C Subunit of Elongator complex genetic 1 1 1 Synthetic Growth Defect
PEX2 YJL210W RING-finger peroxin and E3 ubiquitin ligase genetic 1 1 1 Negative Genetic
DAL81 YIR023W Positive regulator of genes in multiple nitrogen degradation pathways genetic 1 1 1 Negative Genetic
HPC2 YBR215W Subunit of the HIR complex genetic 1 1 1 Synthetic Growth Defect
BRN1 YBL097W Subunit of the condensin complex genetic 1 1 1 Negative Genetic
BUB1 YGR188C Protein kinase involved in the cell cycle checkpoint into anaphase genetic 1 1 1 Negative Genetic
DBF4 YDR052C Regulatory subunit of Cdc7p-Dbf4p kinase complex genetic 1 1 1 Positive Genetic
EPS1 YIL005W ER protein with chaperone and co-chaperone activity genetic 1 1 1 Synthetic Growth Defect
GIM4 YEL003W Subunit of the heterohexameric cochaperone prefoldin complex genetic 1 1 1 Synthetic Growth Defect
ECO1 YFR027W Acetyltransferase required for sister chromatid cohesion genetic 1 1 1 Negative Genetic
MAD1 YGL086W Coiled-coil protein involved in spindle-assembly checkpoint genetic 1 1 1 Negative Genetic
MCM3 YEL032W Protein involved in DNA replication genetic 1 1 1 Synthetic Rescue
ORC3 YLL004W Subunit of the origin recognition complex (ORC) genetic 1 1 1 Negative Genetic
OST3 YOR085W Gamma subunit of the oligosaccharyltransferase complex of the ER lumen genetic 1 1 1 Positive Genetic
PAN1 YIR006C Part of actin cytoskeleton-regulatory complex Pan1p-Sla1p-End3p genetic 1 1 1 Negative Genetic
DPH2 YKL191W Protein required for synthesis of diphthamide genetic 1 1 1 Synthetic Growth Defect
GLN3 YER040W Transcriptional activator in nitrogen catabolite repression system genetic 1 1 1 Phenotypic Enhancement
MOB1 YIL106W Component of the mitotic exit network genetic 1 1 1 Negative Genetic
BAG7 YOR134W Rho GTPase activating protein (RhoGAP) genetic 1 1 1 Synthetic Rescue
CSG2 YBR036C Endoplasmic reticulum membrane protein genetic 1 1 1 Negative Genetic
EMC5 YIL027C Member of conserved ER transmembrane complex genetic 1 1 1 Negative Genetic
MCM7 YBR202W Component of the Mcm2-7 hexameric helicase complex genetic 1 1 1 Negative Genetic
ESC2 YDR363W Sumo-like domain protein genetic 1 1 1 Negative Genetic
DPH6 YLR143W Diphthamide synthetase genetic 1 1 1 Synthetic Growth Defect
CDC19 YAL038W Pyruvate kinase genetic 1 1 1 Negative Genetic
MET32 YDR253C Zinc-finger DNA-binding transcription factor genetic 1 1 1 Negative Genetic
MKK1 YOR231W MAPKK involved in the protein kinase C signaling pathway genetic 1 1 1 Negative Genetic
AZF1 YOR113W Zinc-finger transcription factor genetic 1 1 1 Synthetic Growth Defect
PBP1 YGR178C Component of glucose deprivation induced stress granules genetic 1 1 1 Negative Genetic
CHS5 YLR330W Component of the exomer complex genetic 1 1 1 Synthetic Growth Defect
HHT2 YNL031C Histone H3 physical 1 1 1 Affinity Capture-Western
APN2 YBL019W Class II abasic (AP) endonuclease involved in repair of DNA damage genetic 1 1 1 Synthetic Lethality
HOC1 YJR075W Alpha-1,6-mannosyltransferase genetic 1 1 1 Positive Genetic
EIS1 YMR031C Component of the eisosome required for proper eisosome assembly genetic 1 1 1 Synthetic Rescue
MID1 YNL291C Stretch-activated Ca2+-permeable cation channel genetic 1 1 1 Synthetic Growth Defect
DBP6 YNR038W Essential protein involved in ribosome biogenesis genetic 1 1 1 Negative Genetic
MIT1 YEL007W Transcriptional regulator of pseudohyphal growth genetic 1 1 1 Synthetic Growth Defect
GPB1 YOR371C Multistep regulator of cAMP-PKA signaling genetic 1 1 1 Synthetic Growth Defect
HCM1 YCR065W Forkhead transcription factor genetic 1 1 1 Positive Genetic
ALG1 YBR110W Mannosyltransferase genetic 1 1 1 Positive Genetic
MMS1 YPR164W Subunit of E3 ubiquitin ligase complex involved in replication repair genetic 1 1 1 Positive Genetic
ORC6 YHR118C Subunit of the origin recognition complex (ORC) genetic 1 1 1 Negative Genetic
ESBP6 YNL125C Protein with similarity to monocarboxylate permeases genetic 1 1 1 Synthetic Growth Defect
GPI2 YPL076W Protein involved in the synthesis of GlcNAc-PI genetic 1 1 1 Negative Genetic
IRC7 YFR055W Cysteine desulphydrase, enables growth on cysteine as nitrogen source genetic 1 1 1 Synthetic Rescue
BPH1 YCR032W Protein homologous to Chediak-Higashi syndrome and Beige proteins genetic 1 1 1 Synthetic Growth Defect
NTH1 YDR001C Neutral trehalase, degrades trehalose genetic 1 1 1 Synthetic Rescue
GLO2 YDR272W Cytoplasmic glyoxalase II genetic 1 1 1 Synthetic Rescue
AIM22 YJL046W Lipoate-protein ligase genetic 1 1 1 Positive Genetic
PDC2 YDR081C Transcription factor for thiamine-regulated genes genetic 1 1 1 Negative Genetic
BRL1 YHR036W Essential nuclear envelope/ER integral membrane protein genetic 1 1 1 Negative Genetic
MTC1 YJL123C Protein of unknown function that may interact with ribosomes genetic 1 1 1 Synthetic Growth Defect
GEP7 YGL057C Protein of unknown function genetic 1 1 1 Synthetic Rescue
PMR1 YGL167C High affinity Ca2+/Mn2+ P-type ATPase genetic 1 1 1 Negative Genetic
IMP21 YIL154C Transcriptional activator involved in maintenance of ion homeostasis genetic 1 1 1 Negative Genetic
ORC4 YPR162C Subunit of the origin recognition complex (ORC) genetic 1 1 1 Negative Genetic
KIN4 YOR233W Serine/threonine protein kinase genetic 1 1 1 Negative Genetic
LAM1 YHR155W Putative sterol transfer protein genetic 1 1 1 Synthetic Growth Defect
ELF1 YKL160W Transcription elongation factor with a conserved zinc finger domain genetic 1 1 1 Synthetic Growth Defect
CYK3 YDL117W SH3-domain protein located in the bud neck and cytokinetic actin ring genetic 1 1 1 Negative Genetic
HFD1 YMR110C Dehydrogenase involved in ubiquinone and sphingolipid metabolism genetic 1 1 1 Synthetic Rescue
POC4 YPL144W Component of a heterodimeric Poc4p-Irc25p chaperone genetic 1 1 1 Positive Genetic
PEX32 YBR168W Peroxisomal integral membrane protein genetic 1 1 1 Synthetic Rescue
PET130 YJL023C Protein of unknown function genetic 1 1 1 Synthetic Growth Defect
ABZ2 YMR289W Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase) genetic 1 1 1 Negative Genetic
CSA1 YPR174C Protein of unknown function genetic 1 1 1 Negative Genetic
NUP192 YJL039C Essential subunit of inner ring of nuclear pore complex (NPC) genetic 1 1 1 Negative Genetic
DPH5 YLR172C Methyltransferase required for synthesis of diphthamide genetic 1 1 1 Synthetic Growth Defect
ARO2 YGL148W Bifunctional chorismate synthase and flavin reductase genetic 1 1 1 Synthetic Rescue
APJ1 YNL077W Hsp40 chaperone with a role in SUMO-mediated protein degradation physical 1 1 1 Affinity Capture-MS
ATG21 YPL100W Phosphoinositide binding protein genetic 1 1 1 Synthetic Growth Defect
CMK2 YOL016C Calmodulin-dependent protein kinase physical 1 1 1 Biochemical Activity
DEG1 YFL001W tRNA:pseudouridine synthase genetic 1 1 1 Synthetic Growth Defect
IRC5 YFR038W Putative ATPase containing the DEAD/H helicase-related sequence motif genetic 1 1 1 Synthetic Rescue
ORM1 YGR038W Protein that mediates sphingolipid homeostasis genetic 1 1 1 Synthetic Rescue
HUR1 YGL168W Protein with a role in DNA repair genetic 1 1 1 Negative Genetic
ALG6 YOR002W ER-luminal alpha 1,3 glucosyltransferase genetic 1 1 1 Synthetic Rescue
CYT1 YOR065W Cytochrome c1 genetic 1 1 1 Positive Genetic
GPI19 YDR437W Subunit of GPI-GlcNAc transferase involved in synthesis of GlcNAc-PI genetic 1 1 1 Negative Genetic
DCR2 YLR361C Protein phosphatase genetic 1 1 1 Synthetic Growth Defect
GUT2 YIL155C Mitochondrial glycerol-3-phosphate dehydrogenase genetic 1 1 1 Synthetic Rescue
JJJ3 YJR097W Iron-binding protein genetic 1 1 1 Synthetic Growth Defect
NCB2 YDR397C Subunit of a heterodimeric NC2 transcription regulator complex genetic 1 1 1 Synthetic Growth Defect
DFG16 YOR030W Probable multiple transmembrane protein genetic 1 1 1 Synthetic Growth Defect
MSA1 YOR066W Activator of G1-specific transcription factors MBF and SBF genetic 1 1 1 Dosage Rescue
NEO1 YIL048W Phospholipid translocase (flippase) genetic 1 1 1 Positive Genetic
ILM1 YJR118C Protein of unknown function genetic 1 1 1 Synthetic Growth Defect
ALG7 YBR243C UDP-N-acetyl-glucosamine-1-P transferase genetic 1 1 1 Synthetic Rescue
FLC1 YPL221W Flavin adenine dinucleotide transporter genetic 1 1 1 Positive Genetic
MRL1 YPR079W Membrane protein genetic 1 1 1 Synthetic Growth Defect
ERP6 YGL002W Member of the p24 family involved in ER to Golgi transport genetic 1 1 1 Synthetic Rescue
ERG3 YLR056W C-5 sterol desaturase genetic 1 1 1 Synthetic Growth Defect
MRN1 YPL184C RNA-binding protein that may be involved in translational regulation genetic 1 1 1 Synthetic Growth Defect
BRR6 YGL247W Essential nuclear envelope integral membrane protein genetic 1 1 1 Negative Genetic
CDC8 YJR057W Nucleoside monophosphate and nucleoside diphosphate kinase genetic 1 1 1 Negative Genetic
FIT2 YOR382W Mannoprotein that is incorporated into the cell wall genetic 1 1 1 Negative Genetic
FLO1 YAR050W Lectin-like protein involved in flocculation genetic 1 1 1 Negative Genetic
FLC3 YGL139W Putative FAD transporter, similar to Flc1p and Flc2p genetic 1 1 1 Synthetic Rescue
FKS3 YMR306W Protein involved in spore wall assembly genetic 1 1 1 Negative Genetic
ATO2 YNR002C Putative transmembrane protein involved in export of ammonia genetic 1 1 1 Synthetic Growth Defect
AIM14 YGL160W NADPH oxidase localized to the perinuclear ER genetic 1 1 1 Synthetic Rescue
NCS6 YGL211W Protein required for uridine thiolation of Gln, Lys, and Glu tRNAs genetic 1 1 1 Positive Genetic
MTC3 YGL226W Protein of unknown function genetic 1 1 1 Positive Genetic
MDL2 YPL270W Mitochondrial inner membrane half-type ABC transporter genetic 1 1 1 Negative Genetic
GPI15 YNL038W Protein involved in the synthesis of GlcNAc-PI genetic 1 1 1 Synthetic Rescue
CDC1 YDR182W Putative mannose-ethanolamine phosphate phosphodiesterase genetic 1 1 1 Positive Genetic
HEM3 YDL205C Porphobilinogen deaminase genetic 1 1 1 Synthetic Rescue
FLX1 YIL134W Mitochondrial flavin adenine dinucleotide transporter genetic 1 1 1 Negative Genetic
PER1 YCR044C Protein of the endoplasmic reticulum genetic 1 1 1 Synthetic Growth Defect
JEN1 YKL217W Monocarboxylate/proton symporter of the plasma membrane genetic 1 1 1 Negative Genetic
MMM1 YLL006W ER integral membrane protein, ERMES complex subunit genetic 1 1 1 Negative Genetic
PHO5 YBR093C Repressible acid phosphatase genetic 1 1 1 Synthetic Rescue
PKP1 YIL042C Mitochondrial protein kinase genetic 1 1 1 Synthetic Growth Defect
PIF1 YML061C DNA helicase, potent G-quadruplex DNA binder/unwinder genetic 1 1 1 Synthetic Lethality
OAR1 YKL055C Mitochondrial 3-oxoacyl-[acyl-carrier-protein] reductase genetic 1 1 1 Positive Genetic
ILT1 YDR090C Protein of unknown function genetic 1 1 1 Synthetic Growth Defect
MSH1 YHR120W DNA-binding protein of the mitochondria genetic 1 1 1 Negative Genetic
GPI11 YDR302W ER membrane protein involved in a late step of GPI anchor assembly genetic 1 1 1 Negative Genetic
DBR1 YKL149C RNA lariat debranching enzyme genetic 1 1 1 Negative Genetic
PCP1 YGR101W Mitochondrial serine protease genetic 1 1 1 Synthetic Growth Defect
MTC4 YBR255W Protein of unknown function genetic 1 1 1 Synthetic Growth Defect