DPB2 |
YPR175W |
Second largest subunit of DNA polymerase II (DNA polymerase epsilon) |
physical |
33 |
7 |
24 |
Affinity Capture-MS, Affinity Capture-Western, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Co-purification, Co-purification, Co-fractionation, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Co-crystal Structure, Affinity Capture-Western, Co-purification, Two-hybrid, Two-hybrid, Two-hybrid, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Two-hybrid, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western |
RNH201 |
YNL072W |
Ribonuclease H2 catalytic subunit |
genetic |
18 |
5 |
13 |
Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Rescue, Phenotypic Suppression, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Lethality, Synthetic Growth Defect, Phenotypic Suppression, Synthetic Lethality |
DPB3 |
YBR278W |
Third-largest subunit of DNA polymerase II (DNA polymerase epsilon) |
physical |
15 |
6 |
14 |
Affinity Capture-MS, Affinity Capture-Western, Two-hybrid, Two-hybrid, Affinity Capture-MS, Co-purification, Co-purification, Co-purification, Co-fractionation, Affinity Capture-MS, Co-purification, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex |
DPB4 |
YDR121W |
Subunit of DNA pol epsilon and of ISW2 chromatin accessibility complex |
physical |
15 |
6 |
14 |
Affinity Capture-Western, Affinity Capture-Western, Two-hybrid, Affinity Capture-Western, Affinity Capture-MS, Co-purification, Co-purification, Co-purification, Co-fractionation, Affinity Capture-MS, Affinity Capture-MS, Co-purification, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex |
CTF18 |
YMR078C |
Subunit of a complex with Ctf8p |
physical |
9 |
4 |
6 |
Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Two-hybrid, Reconstituted Complex, Reconstituted Complex, Affinity Capture-Western, Two-hybrid |
DPB2 |
YPR175W |
Second largest subunit of DNA polymerase II (DNA polymerase epsilon) |
genetic |
8 |
4 |
7 |
Dosage Rescue, Synthetic Lethality, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Lethality |
TOP1 |
YOL006C |
Topoisomerase I |
genetic |
8 |
3 |
7 |
Synthetic Rescue, Phenotypic Suppression, Synthetic Rescue, Phenotypic Suppression, Phenotypic Enhancement, Synthetic Rescue, Phenotypic Suppression, Synthetic Rescue |
POL3 |
YDL102W |
Catalytic subunit of DNA polymerase delta |
genetic |
7 |
5 |
7 |
Synthetic Lethality, Phenotypic Enhancement, Synthetic Growth Defect, Negative Genetic, Phenotypic Suppression, Phenotypic Enhancement, Phenotypic Enhancement |
MSH2 |
YOL090W |
Protein that binds to DNA mismatches |
genetic |
7 |
3 |
6 |
Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Suppression, Synthetic Lethality, Phenotypic Enhancement, Phenotypic Enhancement |
MSH6 |
YDR097C |
Protein required for mismatch repair in mitosis and meiosis |
genetic |
7 |
3 |
6 |
Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Lethality, Phenotypic Enhancement, Phenotypic Enhancement |
EXO1 |
YOR033C |
5'-3' exonuclease and flap-endonuclease |
genetic |
6 |
2 |
6 |
Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Rescue |
DPB11 |
YJL090C |
DNA replication initiation protein |
genetic |
6 |
4 |
5 |
Dosage Rescue, Synthetic Lethality, Dosage Rescue, Synthetic Growth Defect, Negative Genetic, Dosage Rescue |
PSF1 |
YDR013W |
Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) |
genetic |
5 |
4 |
5 |
Dosage Rescue, Phenotypic Enhancement, Synthetic Growth Defect, Negative Genetic, Phenotypic Enhancement |
REV3 |
YPL167C |
Catalytic subunit of DNA polymerase zeta |
genetic |
5 |
1 |
5 |
Phenotypic Suppression, Phenotypic Suppression, Phenotypic Suppression, Phenotypic Suppression, Phenotypic Suppression |
MRC1 |
YCL061C |
S-phase checkpoint protein required for DNA replication |
physical |
5 |
2 |
2 |
Two-hybrid, Two-hybrid, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western |
DPB4 |
YDR121W |
Subunit of DNA pol epsilon and of ISW2 chromatin accessibility complex |
genetic |
4 |
4 |
4 |
Dosage Rescue, Synthetic Lethality, Phenotypic Enhancement, Negative Genetic |
SLD5 |
YDR489W |
Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) |
physical |
4 |
3 |
4 |
Affinity Capture-Western, Affinity Capture-Western, Co-purification, Affinity Capture-MS |
RAD24 |
YER173W |
Checkpoint protein |
genetic |
4 |
3 |
4 |
Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Phenotypic Enhancement |
POL32 |
YJR043C |
Third subunit of DNA polymerase delta |
genetic |
4 |
3 |
4 |
Synthetic Growth Defect, Negative Genetic, Synthetic Lethality, Synthetic Lethality |
RAD52 |
YML032C |
Protein involved in homologous recombination |
genetic |
4 |
3 |
4 |
Synthetic Growth Defect, Negative Genetic, Synthetic Lethality, Negative Genetic |
MRE11 |
YMR224C |
Nuclease subunit of the MRX complex with Rad50p and Xrs2p |
genetic |
4 |
4 |
3 |
Synthetic Growth Defect, Phenotypic Enhancement, Negative Genetic, Synthetic Lethality |
HST3 |
YOR025W |
Sirtuin, histone H3 deacetylase |
genetic |
4 |
4 |
3 |
Synthetic Growth Defect, Synthetic Lethality, Phenotypic Enhancement, Negative Genetic |
MRC1 |
YCL061C |
S-phase checkpoint protein required for DNA replication |
genetic |
4 |
4 |
3 |
Synthetic Lethality, Dosage Rescue, Synthetic Growth Defect, Negative Genetic |
PMS1 |
YNL082W |
ATP-binding protein required for mismatch repair |
genetic |
4 |
3 |
3 |
Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Lethality, Phenotypic Enhancement |
DUN1 |
YDL101C |
Cell-cycle checkpoint S/T protein kinase |
genetic |
4 |
3 |
2 |
Synthetic Lethality, Phenotypic Suppression, Synthetic Rescue, Phenotypic Suppression |
DPB3 |
YBR278W |
Third-largest subunit of DNA polymerase II (DNA polymerase epsilon) |
genetic |
3 |
3 |
3 |
Dosage Rescue, Synthetic Growth Defect, Negative Genetic |
RRM3 |
YHR031C |
DNA helicase involved in rDNA replication and Ty1 transposition |
genetic |
3 |
3 |
3 |
Synthetic Growth Defect, Negative Genetic, Phenotypic Enhancement |
RAD9 |
YDR217C |
DNA damage-dependent checkpoint protein |
genetic |
3 |
3 |
3 |
Synthetic Growth Defect, Negative Genetic, Phenotypic Enhancement |
RNH1 |
YMR234W |
Ribonuclease H1 |
genetic |
3 |
2 |
3 |
Synthetic Lethality, Synthetic Lethality, Dosage Rescue |
DPB11 |
YJL090C |
DNA replication initiation protein |
physical |
3 |
2 |
3 |
Affinity Capture-Western, Two-hybrid, Affinity Capture-Western |
MCM4 |
YPR019W |
Essential helicase component of heterohexameric MCM2-7 complexes |
physical |
3 |
2 |
3 |
Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western |
CTF18 |
YMR078C |
Subunit of a complex with Ctf8p |
genetic |
3 |
3 |
2 |
Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Lethality |
TRF5 |
YNL299W |
Non-canonical poly(A) polymerase |
physical |
3 |
2 |
1 |
Affinity Capture-Western, Two-hybrid, Two-hybrid |
ARP4 |
YJL081C |
Nuclear actin-related protein involved in chromatin remodeling |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Negative Genetic |
BRE1 |
YDL074C |
E3 ubiquitin ligase |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Negative Genetic |
LSM1 |
YJL124C |
Lsm (Like Sm) protein |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Negative Genetic |
PAT1 |
YCR077C |
Deadenylation-dependent mRNA-decapping factor |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Negative Genetic |
ASF1 |
YJL115W |
Nucleosome assembly factor |
genetic |
2 |
2 |
2 |
Phenotypic Suppression, Synthetic Growth Defect |
CDC14 |
YFR028C |
Protein phosphatase required for mitotic exit |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Negative Genetic |
CDC45 |
YLR103C |
DNA replication initiation factor |
physical |
2 |
2 |
2 |
Co-purification, Affinity Capture-Western |
HDA1 |
YNL021W |
Catalytic subunit of class II HDA1 histone deacetylase complex |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Negative Genetic |
HTB2 |
YBL002W |
Histone H2B |
physical |
2 |
2 |
2 |
Affinity Capture-MS, Affinity Capture-Western |
MSH3 |
YCR092C |
Mismatch repair protein |
genetic |
2 |
2 |
2 |
Phenotypic Enhancement, Synthetic Lethality |
IES5 |
YER092W |
Non-essential INO80 chromatin remodeling complex subunit |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Negative Genetic |
PRI1 |
YIR008C |
Subunit of DNA primase |
physical |
2 |
2 |
2 |
Reconstituted Complex, Co-purification |
SLD2 |
YKL108W |
Single-stranded DNA origin-binding and annealing protein |
physical |
2 |
2 |
2 |
Reconstituted Complex, Affinity Capture-Western |
SEN1 |
YLR430W |
ATP-dependent 5' to 3' RNA/DNA and DNA helicase |
genetic |
2 |
2 |
2 |
Negative Genetic, Synthetic Lethality |
RFA1 |
YAR007C |
Subunit of heterotrimeric Replication Protein A (RPA) |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Negative Genetic |
SRS2 |
YJL092W |
DNA helicase and DNA-dependent ATPase |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Synthetic Growth Defect |
PPH21 |
YDL134C |
Catalytic subunit of protein phosphatase 2A, PP2A |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Negative Genetic |
PSF2 |
YJL072C |
Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Negative Genetic |
RAD17 |
YOR368W |
Checkpoint protein |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Negative Genetic |
RIM8 |
YGL045W |
Protein involved in proteolytic activation of Rim101p |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Negative Genetic |
SPN1 |
YPR133C |
Protein involved in RNA polymerase II transcription |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Negative Genetic |
SWC5 |
YBR231C |
Component of the SWR1 complex |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Negative Genetic |
VID22 |
YLR373C |
G-quadruplex (G4) DNA binding protein |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Positive Genetic |
VIP1 |
YLR410W |
Bifunctional inositol pyrophosphate kinase and phosphatase |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Negative Genetic |
VPS71 |
YML041C |
Nucleosome-binding component of the SWR1 complex |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Negative Genetic |
XRS2 |
YDR369C |
FHA domain-containing component of the Mre11 complex |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Negative Genetic |
RTG2 |
YGL252C |
Sensor of mitochondrial dysfunction |
genetic |
2 |
2 |
2 |
Synthetic Rescue, Negative Genetic |
SDS3 |
YIL084C |
Component of the Rpd3L histone deacetylase complex |
genetic |
2 |
2 |
2 |
Synthetic Rescue, Positive Genetic |
SWI4 |
YER111C |
DNA binding component of the SBF complex (Swi4p-Swi6p) |
genetic |
2 |
2 |
2 |
Synthetic Rescue, Positive Genetic |
TAF12 |
YDR145W |
Subunit (61/68 kDa) of TFIID and SAGA complexes |
genetic |
2 |
2 |
2 |
Synthetic Rescue, Negative Genetic |
RAD51 |
YER095W |
Strand exchange protein |
genetic |
2 |
2 |
2 |
Negative Genetic, Synthetic Growth Defect |
CDC6 |
YJL194W |
Essential ATP-binding protein required for DNA replication |
genetic |
2 |
2 |
2 |
Negative Genetic, Positive Genetic |
LTE1 |
YAL024C |
Protein similar to GDP/GTP exchange factors |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Negative Genetic |
MCM2 |
YBL023C |
Protein involved in DNA replication |
physical |
2 |
2 |
2 |
Affinity Capture-MS, Affinity Capture-Western |
MMS2 |
YGL087C |
Ubiquitin-conjugating enzyme variant |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Synthetic Rescue |
CHK1 |
YBR274W |
Serine/threonine kinase and DNA damage checkpoint effector |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Negative Genetic |
DDC1 |
YPL194W |
DNA damage checkpoint protein |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Negative Genetic |
DIA2 |
YOR080W |
Origin-binding F-box protein |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Negative Genetic |
CTF4 |
YPR135W |
Chromatin-associated protein |
genetic |
2 |
2 |
2 |
Negative Genetic, Synthetic Lethality |
DBF2 |
YGR092W |
Ser/Thr kinase involved in transcription and stress response |
genetic |
2 |
2 |
2 |
Synthetic Rescue, Negative Genetic |
PML1 |
YLR016C |
Subunit of the RES complex |
genetic |
2 |
2 |
2 |
Synthetic Rescue, Negative Genetic |
IPK1 |
YDR315C |
Inositol 1,3,4,5,6-pentakisphosphate 2-kinase |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Negative Genetic |
CSM3 |
YMR048W |
Replication fork associated factor |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Negative Genetic |
AIM4 |
YBR194W |
Protein proposed to be associated with the nuclear pore complex |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Positive Genetic |
CHL1 |
YPL008W |
Probable DNA helicase |
genetic |
2 |
2 |
2 |
Negative Genetic, Synthetic Lethality |
CDC21 |
YOR074C |
Thymidylate synthase |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Negative Genetic |
ARP6 |
YLR085C |
Actin-related protein that binds nucleosomes |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Negative Genetic |
CLB5 |
YPR120C |
B-type cyclin involved in DNA replication during S phase |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Negative Genetic |
CTF8 |
YHR191C |
Subunit of a complex with Ctf18p |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Negative Genetic |
GYP1 |
YOR070C |
Cis-golgi GTPase-activating protein (GAP) for yeast Rabs |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Positive Genetic |
NUP188 |
YML103C |
Subunit of the inner ring of the nuclear pore complex (NPC) |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Negative Genetic |
BTS1 |
YPL069C |
Geranylgeranyl diphosphate synthase (GGPPS) |
genetic |
2 |
2 |
2 |
Synthetic Rescue, Positive Genetic |
DCC1 |
YCL016C |
Subunit of a complex with Ctf8p and Ctf18p |
physical |
2 |
2 |
2 |
Affinity Capture-Western, Reconstituted Complex |
DCC1 |
YCL016C |
Subunit of a complex with Ctf8p and Ctf18p |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Negative Genetic |
GCS1 |
YDL226C |
ADP-ribosylation factor GTPase activating protein (ARF GAP) |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Negative Genetic |
ARV1 |
YLR242C |
Cortical ER protein |
genetic |
2 |
2 |
2 |
Synthetic Rescue, Positive Genetic |
HST4 |
YDR191W |
NAD(+)-dependent protein deacetylase |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Phenotypic Enhancement |
LGE1 |
YPL055C |
Protein involved in histone H2B ubiquitination |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Negative Genetic |
NPR3 |
YHL023C |
Subunit of the Iml1p/SEACIT complex |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Negative Genetic |
CDC33 |
YOL139C |
Translation initiation factor eIF4E |
physical |
2 |
1 |
2 |
Affinity Capture-MS, Affinity Capture-MS |
TIF4631 |
YGR162W |
Translation initiation factor eIF4G and scaffold protein |
physical |
2 |
1 |
2 |
Affinity Capture-MS, Affinity Capture-MS |
PUF3 |
YLL013C |
Protein of the mitochondrial outer surface |
physical |
2 |
1 |
2 |
Affinity Capture-RNA, Affinity Capture-RNA |
RAD27 |
YKL113C |
5' to 3' exonuclease, 5' flap endonuclease |
genetic |
2 |
1 |
2 |
Phenotypic Enhancement, Phenotypic Enhancement |
POL30 |
YBR088C |
Proliferating cell nuclear antigen (PCNA) |
genetic |
2 |
1 |
2 |
Phenotypic Suppression, Phenotypic Suppression |
MCM3 |
YEL032W |
Protein involved in DNA replication |
physical |
2 |
1 |
2 |
Affinity Capture-Western, Affinity Capture-Western |
MMS21 |
YEL019C |
Highly conserved SUMO E3 ligase subunit of SMC5-SMC6 complex |
physical |
2 |
2 |
1 |
Affinity Capture-Western, Biochemical Activity |
TRF5 |
YNL299W |
Non-canonical poly(A) polymerase |
genetic |
2 |
2 |
1 |
Synthetic Growth Defect, Synthetic Lethality |
SMC1 |
YFL008W |
Subunit of the multiprotein cohesin complex |
genetic |
2 |
2 |
1 |
Synthetic Growth Defect, Synthetic Lethality |
RTT107 |
YHR154W |
BRCA1 C-terminal domain protein needed for recovery from DNA damage |
physical |
2 |
2 |
1 |
Affinity Capture-Western, Two-hybrid |
RNR4 |
YGR180C |
Ribonucleotide-diphosphate reductase (RNR) small subunit |
genetic |
2 |
2 |
1 |
Phenotypic Enhancement, Phenotypic Suppression |
SGT1 |
YOR057W |
Cochaperone protein |
genetic |
2 |
2 |
1 |
Positive Genetic, Negative Genetic |
PAP2 |
YOL115W |
Non-canonical poly(A) polymerase |
physical |
2 |
2 |
1 |
Affinity Capture-Western, Two-hybrid |
PAP2 |
YOL115W |
Non-canonical poly(A) polymerase |
genetic |
2 |
2 |
1 |
Dosage Rescue, Synthetic Growth Defect |
HNT3 |
YOR258W |
DNA 5' AMP hydrolase involved in DNA repair |
genetic |
2 |
2 |
1 |
Synthetic Growth Defect, Phenotypic Enhancement |
HSC82 |
YMR186W |
Cytoplasmic chaperone of the Hsp90 family |
physical |
2 |
1 |
1 |
Affinity Capture-MS, Affinity Capture-MS |
SFP1 |
YLR403W |
Regulates transcription of ribosomal protein and biogenesis genes |
regulation |
1 |
1 |
1 |
DNA to cDNA expression microarray evidence |
STP1 |
YDR463W |
Transcription factor |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
REB1 |
YBR049C |
RNA polymerase I enhancer binding protein |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
YAP5 |
YIR018W |
Basic leucine zipper (bZIP) iron-sensing transcription factor |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
UGA3 |
YDL170W |
Transcriptional activator for GABA-dependent induction of GABA genes |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
SMC5 |
YOL034W |
Subunit of the SMC5-SMC6 complex |
regulation |
1 |
1 |
1 |
qualitative western immunoblotting evidence |
SMC6 |
YLR383W |
Subunit of the SMC5-SMC6 complex |
regulation |
1 |
1 |
1 |
qualitative western immunoblotting evidence |
CDC73 |
YLR418C |
Component of the Paf1p complex |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
CHD1 |
YER164W |
Chromatin remodeler that regulates various aspects of transcription |
genetic |
1 |
1 |
1 |
Negative Genetic |
DSN1 |
YIR010W |
Essential component of the outer kinetochore MIND complex |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
CBF5 |
YLR175W |
Pseudouridine synthase catalytic subunit of box H/ACA snoRNPs |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
POB3 |
YML069W |
Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
CKA1 |
YIL035C |
Alpha catalytic subunit of casein kinase 2 (CK2) |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
CKB1 |
YGL019W |
Beta regulatory subunit of casein kinase 2 (CK2) |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
CKB2 |
YOR039W |
Beta' regulatory subunit of casein kinase 2 (CK2) |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
NSE3 |
YDR288W |
Component of the SMC5-SMC6 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
GLC7 |
YER133W |
Type 1 S/T protein phosphatase (PP1) catalytic subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
ESA1 |
YOR244W |
Catalytic subunit of the histone acetyltransferase complex (NuA4) |
genetic |
1 |
1 |
1 |
Negative Genetic |
BRX1 |
YOL077C |
Nucleolar protein |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
NOP4 |
YPL043W |
Nucleolar protein |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
PLB1 |
YMR008C |
Phospholipase B (lysophospholipase) involved in lipid metabolism |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
PFK27 |
YOL136C |
6-phosphofructo-2-kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
NSE4 |
YDL105W |
Component of the SMC5-SMC6 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
MRT4 |
YKL009W |
Protein involved in mRNA turnover and ribosome assembly |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
MES1 |
YGR264C |
Methionyl-tRNA synthetase |
genetic |
1 |
1 |
1 |
Negative Genetic |
DBP3 |
YGL078C |
RNA-Dependent ATPase, member of DExD/H-box family |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
GAR1 |
YHR089C |
Protein component of the H/ACA snoRNP pseudouridylase complex |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
NOP56 |
YLR197W |
Essential evolutionarily-conserved nucleolar protein |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
NOP1 |
YDL014W |
Histone glutamine methyltransferase, modifies H2A at Q105 in nucleolus |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
CDC33 |
YOL139C |
Translation initiation factor eIF4E |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
LRP1 |
YHR081W |
Nuclear exosome-associated nucleic acid binding protein |
genetic |
1 |
1 |
1 |
Positive Genetic |
DST1 |
YGL043W |
General transcription elongation factor TFIIS |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
HCR1 |
YLR192C |
eIF3j component of translation initiation factor 3 (eIF3) |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
ACT1 |
YFL039C |
Actin, structural protein in cytoskeleton |
genetic |
1 |
1 |
1 |
Negative Genetic |
KAP95 |
YLR347C |
Karyopherin beta |
genetic |
1 |
1 |
1 |
Negative Genetic |
CFT2 |
YLR115W |
Subunit of the mRNA cleavage and polyadenlylation factor (CPF) |
genetic |
1 |
1 |
1 |
Positive Genetic |
CCR4 |
YAL021C |
Component of the CCR4-NOT transcriptional complex |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
NAB2 |
YGL122C |
Nuclear polyadenylated RNA-binding protein |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
ARC18 |
YLR370C |
Subunit of the ARP2/3 complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
BEM1 |
YBR200W |
Protein containing SH3-domains |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
BET3 |
YKR068C |
Core component of transport protein particle (TRAPP) complexes I-III |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
ASC1 |
YMR116C |
G-protein beta subunit and guanine dissociation inhibitor for Gpa2p |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
ASC1 |
YMR116C |
G-protein beta subunit and guanine dissociation inhibitor for Gpa2p |
genetic |
1 |
1 |
1 |
Positive Genetic |
CAF40 |
YNL288W |
Component of the CCR4-NOT transcriptional complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
CDC24 |
YAL041W |
Guanine nucleotide exchange factor (GEF) for Cdc42p |
genetic |
1 |
1 |
1 |
Negative Genetic |
CDC28 |
YBR160W |
Cyclin-dependent kinase (CDK) catalytic subunit |
physical |
1 |
1 |
1 |
Biochemical Activity |
CDC45 |
YLR103C |
DNA replication initiation factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
BUD31 |
YCR063W |
Component of the SF3b subcomplex of the U2 snRNP |
genetic |
1 |
1 |
1 |
Negative Genetic |
CKS1 |
YBR135W |
Cyclin-dependent protein kinase regulatory subunit and adaptor |
genetic |
1 |
1 |
1 |
Negative Genetic |
COP1 |
YDL145C |
Alpha subunit of COPI vesicle coatomer complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
CTK1 |
YKL139W |
Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I) |
genetic |
1 |
1 |
1 |
Positive Genetic |
DNA2 |
YHR164C |
ATP-dependent 5'-flap endonuclease and DNA helicase |
genetic |
1 |
1 |
1 |
Negative Genetic |
CIA2 |
YHR122W |
Component of cytosolic iron-sulfur protein assembly (CIA) machinery |
genetic |
1 |
1 |
1 |
Negative Genetic |
ELP2 |
YGR200C |
Subunit of Elongator complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
EAF3 |
YPR023C |
Component of the Rpd3S histone deacetylase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
FIP1 |
YJR093C |
Subunit of cleavage polyadenylation factor (CPF) |
genetic |
1 |
1 |
1 |
Negative Genetic |
FRS1 |
YLR060W |
Beta subunit of cytoplasmic phenylalanyl-tRNA synthetase |
genetic |
1 |
1 |
1 |
Negative Genetic |
GCN1 |
YGL195W |
Positive regulator of the Gcn2p kinase activity |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
ERV25 |
YML012W |
Member of the p24 family involved in ER to Golgi transport |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
DHH1 |
YDL160C |
Cytoplasmic DEAD-box helicase and mRNA decapping activator |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
HSM3 |
YBR272C |
Evolutionarily conserved 19S regulatory particle assembly-chaperone |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
IPP1 |
YBR011C |
Cytoplasmic inorganic pyrophosphatase (PPase) |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
IOC3 |
YFR013W |
Subunit of the Isw1a complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
ISW1 |
YBR245C |
ATPase subunit of imitation-switch (ISWI) class chromatin remodelers |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
ISW1 |
YBR245C |
ATPase subunit of imitation-switch (ISWI) class chromatin remodelers |
genetic |
1 |
1 |
1 |
Negative Genetic |
HSL1 |
YKL101W |
Nim1p-related protein kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
LAS17 |
YOR181W |
Actin assembly factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
LSM7 |
YNL147W |
Lsm (Like Sm) protein |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
MBP1 |
YDL056W |
Transcription factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
MCD1 |
YDL003W |
Essential alpha-kleisin subunit of the cohesin complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
MCM5 |
YLR274W |
Component of the Mcm2-7 hexameric helicase complex |
physical |
1 |
1 |
1 |
Co-purification |
MCM5 |
YLR274W |
Component of the Mcm2-7 hexameric helicase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
MED1 |
YPR070W |
Subunit of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
FAB1 |
YFR019W |
1-phosphatidylinositol-3-phosphate 5-kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
MLH1 |
YMR167W |
Protein required for mismatch repair in mitosis and meiosis |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
HRR25 |
YPL204W |
Conserved casein kinase, monopolin subunit |
physical |
1 |
1 |
1 |
Biochemical Activity |
HRR25 |
YPL204W |
Conserved casein kinase, monopolin subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
HDA3 |
YPR179C |
Subunit of HDA1 histone deacetylase complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
MSH2 |
YOL090W |
Protein that binds to DNA mismatches |
physical |
1 |
1 |
1 |
Co-localization |
MEC1 |
YBR136W |
Genome integrity checkpoint protein and PI kinase superfamily member |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
MPH1 |
YIR002C |
3'-5' DNA helicase involved in error-free bypass of DNA lesions |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
HTZ1 |
YOL012C |
Histone variant H2AZ |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
NBP35 |
YGL091C |
Essential cytoplasmic iron-sulfur cluster binding protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
NCL1 |
YBL024W |
S-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
NHP10 |
YDL002C |
Non-essential INO80 chromatin remodeling complex subunit |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
NPL4 |
YBR170C |
Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase |
genetic |
1 |
1 |
1 |
Negative Genetic |
NUP159 |
YIL115C |
FG-nucleoporin component of central core of the nuclear pore complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
ORC1 |
YML065W |
Largest subunit of the origin recognition complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
ORC2 |
YBR060C |
Subunit of the origin recognition complex (ORC) |
genetic |
1 |
1 |
1 |
Negative Genetic |
AFG2 |
YLR397C |
ATPase of the CDC48/PAS1/SEC18 (AAA) family, forms a hexameric complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
GIM3 |
YNL153C |
Subunit of the heterohexameric cochaperone prefoldin complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
PCF11 |
YDR228C |
mRNA 3' end processing factor |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
PDB1 |
YBR221C |
E1 beta subunit of the pyruvate dehydrogenase (PDH) complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
POL1 |
YNL102W |
Catalytic subunit of the DNA polymerase I alpha-primase complex |
physical |
1 |
1 |
1 |
Reconstituted Complex |
POL1 |
YNL102W |
Catalytic subunit of the DNA polymerase I alpha-primase complex |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
GLE2 |
YER107C |
RNA export factor associated with the nuclear pore complex (NPC) |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
LEA1 |
YPL213W |
Component of U2 snRNP complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
INO4 |
YOL108C |
Transcription factor involved in phospholipid synthesis |
genetic |
1 |
1 |
1 |
Negative Genetic |
MDS3 |
YGL197W |
Putative component of the TOR regulatory pathway |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
PUB1 |
YNL016W |
Poly (A)+ RNA-binding protein |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
SPT5 |
YML010W |
Spt4p/5p (DSIF) transcription elongation factor complex subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
SMC1 |
YFL008W |
Subunit of the multiprotein cohesin complex |
physical |
1 |
1 |
1 |
Two-hybrid |
POL2 |
YNL262W |
Catalytic subunit of DNA polymerase (II) epsilon |
physical |
1 |
1 |
1 |
Two-hybrid |
PRI2 |
YKL045W |
Subunit of DNA primase |
physical |
1 |
1 |
1 |
Reconstituted Complex |
PRI2 |
YKL045W |
Subunit of DNA primase |
genetic |
1 |
1 |
1 |
Negative Genetic |
TDH2 |
YJR009C |
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), isozyme 2 |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
STM1 |
YLR150W |
Protein required for optimal translation under nutrient stress |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RRM3 |
YHR031C |
DNA helicase involved in rDNA replication and Ty1 transposition |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
SLD5 |
YDR489W |
Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) |
genetic |
1 |
1 |
1 |
Negative Genetic |
SBP1 |
YHL034C |
Protein that binds eIF4G and has a role in repression of translation |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
SIZ1 |
YDR409W |
SUMO E3 ligase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
SIZ1 |
YDR409W |
SUMO E3 ligase |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
ULP2 |
YIL031W |
Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
SPT10 |
YJL127C |
Histone H3 acetylase with a role in transcriptional regulation |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
SSB2 |
YNL209W |
Cytoplasmic ATPase that is a ribosome-associated molecular chaperone |
physical |
1 |
1 |
1 |
Co-purification |
SLD2 |
YKL108W |
Single-stranded DNA origin-binding and annealing protein |
genetic |
1 |
1 |
1 |
Dosage Rescue |
VAM6 |
YDL077C |
Guanine nucleotide exchange factor for the GTPase Gtr1p |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
SPT16 |
YGL207W |
Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
RTT107 |
YHR154W |
BRCA1 C-terminal domain protein needed for recovery from DNA damage |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
RPC82 |
YPR190C |
RNA polymerase III subunit C82 |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RAD26 |
YJR035W |
Protein involved in transcription-coupled nucleotide excision repair |
physical |
1 |
1 |
1 |
Co-crystal Structure |
SGV1 |
YPR161C |
Cyclin (Bur2p)-dependent protein kinase |
physical |
1 |
1 |
1 |
Biochemical Activity |
SGV1 |
YPR161C |
Cyclin (Bur2p)-dependent protein kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
YCK2 |
YNL154C |
Palmitoylated plasma membrane-bound casein kinase I (CK1) isoform |
physical |
1 |
1 |
1 |
Biochemical Activity |
YCK3 |
YER123W |
Palmitoylated vacuolar membrane-localized casein kinase I isoform |
physical |
1 |
1 |
1 |
Biochemical Activity |
RIM11 |
YMR139W |
Protein kinase |
physical |
1 |
1 |
1 |
Biochemical Activity |
SSK2 |
YNR031C |
MAP kinase kinase kinase of HOG1 mitogen-activated signaling pathway |
physical |
1 |
1 |
1 |
Biochemical Activity |
SLN1 |
YIL147C |
Transmembrane histidine phosphotransfer kinase and osmosensor |
physical |
1 |
1 |
1 |
Biochemical Activity |
RTT103 |
YDR289C |
Protein involved in transcription termination by RNA polymerase II |
physical |
1 |
1 |
1 |
Reconstituted Complex |
SPT6 |
YGR116W |
Nucleosome remodeling protein |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
SET1 |
YHR119W |
Histone methyltransferase, subunit of the COMPASS (Set1C) complex |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
SMC5 |
YOL034W |
Subunit of the SMC5-SMC6 complex |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
SMT3 |
YDR510W |
Ubiquitin-like protein of the SUMO family |
physical |
1 |
1 |
1 |
Two-hybrid |
SMT3 |
YDR510W |
Ubiquitin-like protein of the SUMO family |
genetic |
1 |
1 |
1 |
Negative Genetic |
RPS0A |
YGR214W |
Ribosomal 40S subunit protein S0A |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RPS10A |
YOR293W |
Protein component of the small (40S) ribosomal subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RPS10A |
YOR293W |
Protein component of the small (40S) ribosomal subunit |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
RPS12 |
YOR369C |
Protein component of the small (40S) ribosomal subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RPS13 |
YDR064W |
Protein component of the small (40S) ribosomal subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RPL26A |
YLR344W |
Ribosomal 60S subunit protein L26A |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RPS3 |
YNL178W |
Protein component of the small (40S) ribosomal subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
SEN1 |
YLR430W |
ATP-dependent 5' to 3' RNA/DNA and DNA helicase |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
RAD53 |
YPL153C |
DNA damage response kinase |
physical |
1 |
1 |
1 |
Biochemical Activity |
RAD53 |
YPL153C |
DNA damage response kinase |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
RFC2 |
YJR068W |
Subunit of heteropentameric Replication factor C (RF-C) |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
POL4 |
YCR014C |
DNA polymerase IV |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
PSF3 |
YOL146W |
Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) |
genetic |
1 |
1 |
1 |
Dosage Rescue |
TTI1 |
YKL033W |
Subunit of the ASTRA complex, involved in chromatin remodeling |
genetic |
1 |
1 |
1 |
Positive Genetic |
TTI2 |
YJR136C |
Subunit of the ASTRA complex, involved in chromatin remodeling |
genetic |
1 |
1 |
1 |
Negative Genetic |
RNH202 |
YDR279W |
Ribonuclease H2 subunit |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
PRE9 |
YGR135W |
Alpha 3 subunit of the 20S proteasome |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
RAD50 |
YNL250W |
Subunit of MRX complex with Mre11p and Xrs2p |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
RAD57 |
YDR004W |
Protein that stimulates strand exchange |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
RIM101 |
YHL027W |
Cys2His2 zinc-finger transcriptional repressor |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
RIM13 |
YMR154C |
Calpain-like cysteine protease |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
RIM21 |
YNL294C |
pH sensor molecule, component of the RIM101 pathway |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
RIM9 |
YMR063W |
Plasma membrane protein of unknown function |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
RRD2 |
YPL152W |
Peptidyl-prolyl cis/trans-isomerase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
RRN9 |
YMR270C |
Protein involved in promoting high level transcription of rDNA |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
RTF1 |
YGL244W |
Subunit of RNAPII-associated chromatin remodeling Paf1 complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
RXT3 |
YDL076C |
Component of the Rpd3L histone deacetylase complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
SAC3 |
YDR159W |
mRNA export factor |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
SAD1 |
YFR005C |
Conserved zinc-finger domain protein involved in pre-mRNA splicing |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
SAF1 |
YBR280C |
F-Box protein involved in proteasome-dependent degradation of Aah1p |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
SAP190 |
YKR028W |
Protein that forms a complex with the Sit4p protein phosphatase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
SET3 |
YKR029C |
Defining member of the SET3 histone deacetylase complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
SGF29 |
YCL010C |
Component of the HAT/Core module of the SAGA, SLIK, and ADA complexes |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
SHE1 |
YBL031W |
Mitotic spindle protein |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
SHE4 |
YOR035C |
Protein containing a UCS (UNC-45/CRO1/SHE4) domain |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
SHR3 |
YDL212W |
Endoplasmic reticulum packaging chaperone |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
SIF2 |
YBR103W |
WD40 repeat-containing subunit of Set3C histone deacetylase complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
SIR1 |
YKR101W |
Protein involved in silencing at mating-type loci HML and HMR |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
SIW14 |
YNL032W |
Inositol phosphatase involved in inositol pyrophosphate metabolism |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
SLT2 |
YHR030C |
Serine/threonine MAP kinase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
SMI1 |
YGR229C |
Protein involved in the regulation of cell wall synthesis |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
SNT1 |
YCR033W |
Set3C histone deacetylase scaffold |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
SNX3 |
YOR357C |
Sorting nexin for late-Golgi enzymes |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
SOH1 |
YGL127C |
Subunit of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
SOK2 |
YMR016C |
Nuclear protein that negatively regulates pseudohyphal differentiation |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
SRB2 |
YHR041C |
Subunit of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
SRN2 |
YLR119W |
Component of the ESCRT-I complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
SSO2 |
YMR183C |
Plasma membrane t-SNARE |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
SWD1 |
YAR003W |
Subunit of the COMPASS (Set1C) complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
SWD3 |
YBR175W |
Essential subunit of the COMPASS (Set1C) complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
SWF1 |
YDR126W |
Palmitoyltransferase that acts on transmembrane proteins |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
SWR1 |
YDR334W |
Swi2/Snf2-related ATPase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
TCO89 |
YPL180W |
Subunit of TORC1 (Tor1p or Tor2p-Kog1p-Lst8p-Tco89p) |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
TIF5 |
YPR041W |
Translation initiation factor eIF5 |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
TIM50 |
YPL063W |
Essential component of the TIM23 complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
TRR2 |
YHR106W |
Mitochondrial thioredoxin reductase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
TRS20 |
YBR254C |
Core component of transport protein particle (TRAPP) complexes I-III |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
TRS85 |
YDR108W |
Component of transport protein particle (TRAPP) complex III |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
TUM1 |
YOR251C |
Rhodanese domain sulfur transferase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
UBA4 |
YHR111W |
E1-like protein that activates Urm1p before urmylation |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
UME6 |
YDR207C |
Rpd3L histone deacetylase complex subunit |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
URM1 |
YIL008W |
Ubiquitin-like protein involved in thiolation of cytoplasmic tRNAs |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
VAC8 |
YEL013W |
Vacuole-specific Myo2p receptor |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
VAM10 |
YOR068C |
Protein involved in vacuole morphogenesis |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
VHS3 |
YOR054C |
Negative regulatory subunit of protein phosphatase 1 Ppz1p |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
VMS1 |
YDR049W |
Peptidyl-tRNA hydrolase that releases stalled peptides from ribosomes, |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
VPS13 |
YLL040C |
Lipid transport protein involved in prospore membrane morphogenesis |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
VPS17 |
YOR132W |
Subunit of the membrane-associated retromer complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
VPS21 |
YOR089C |
Endosomal Rab family GTPase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
VPS29 |
YHR012W |
Subunit of the membrane-associated retromer complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
VPS30 |
YPL120W |
Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
VPS5 |
YOR069W |
Nexin-1 homolog |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
VPS55 |
YJR044C |
Late endosomal protein involved in late endosome to vacuole transport |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
VPS60 |
YDR486C |
Protein involved in late endosome to vacuole transport |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
VPS8 |
YAL002W |
Membrane-binding component of the CORVET complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
XRN1 |
YGL173C |
Evolutionarily-conserved 5'-3' exonuclease |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
YGR122W |
YGR122W |
Protein that may be involved in pH regulation |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
YGR237C |
YGR237C |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
YSC83 |
YHR017W |
Non-essential mitochondrial protein of unknown function |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
PPT1 |
YGR123C |
Protein serine/threonine phosphatase |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
PRE2 |
YPR103W |
Beta 5 subunit of the 20S proteasome |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
PRP11 |
YDL043C |
Subunit of the SF3a splicing factor complex |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
PRP38 |
YGR075C |
Unique component of the U4/U6.U5 tri-snRNP particle |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
PUF6 |
YDR496C |
Pumilio-homology domain protein |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
RAD10 |
YML095C |
Single-stranded DNA endonuclease (with Rad1p) |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
RCK1 |
YGL158W |
Protein kinase involved in oxidative stress response |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
RGR1 |
YLR071C |
Subunit of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
ULS1 |
YOR191W |
Swi2/Snf2-related translocase, SUMO-Targeted Ubiquitin Ligase (STUbL) |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
RKM2 |
YDR198C |
Ribosomal protein lysine methyltransferase |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
RPA43 |
YOR340C |
RNA polymerase I subunit A43 |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
RPC17 |
YJL011C |
RNA polymerase III subunit C17 |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
RPC19 |
YNL113W |
RNA polymerase subunit AC19 |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
RPL13A |
YDL082W |
Ribosomal 60S subunit protein L13A |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
RPL16A |
YIL133C |
Ribosomal 60S subunit protein L16A |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
RPL23A |
YBL087C |
Ribosomal 60S subunit protein L23A |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
RPL24B |
YGR148C |
Ribosomal 60S subunit protein L24B |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
RPL29 |
YFR032C-A |
Ribosomal 60S subunit protein L29 |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
RPL2A |
YFR031C-A |
Ribosomal 60S subunit protein L2A |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
RPL35B |
YDL136W |
Ribosomal 60S subunit protein L35B |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
RPL37B |
YDR500C |
Ribosomal 60S subunit protein L37B |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
RPL9A |
YGL147C |
Ribosomal 60S subunit protein L9A |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
RPN12 |
YFR052W |
Subunit of the 19S regulatory particle of the 26S proteasome lid |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
RPN14 |
YGL004C |
Evolutionarily conserved 19S regulatory particle assembly-chaperone |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
RPN6 |
YDL097C |
Essential, non-ATPase regulatory subunit of the 26S proteasome lid |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
RPN7 |
YPR108W |
Essential non-ATPase regulatory subunit of the 26S proteasome |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
RPP1B |
YDL130W |
Ribosomal protein P1 beta |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
RPS17B |
YDR447C |
Ribosomal protein 51 (rp51) of the small (40s) subunit |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
RPT3 |
YDR394W |
ATPase of the 19S regulatory particle of the 26S proteasome |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
SAP4 |
YGL229C |
Protein required for function of the Sit4p protein phosphatase |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
SCW11 |
YGL028C |
Cell wall protein with similarity to glucanases |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
SEC20 |
YDR498C |
Membrane glycoprotein v-SNARE |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
SGF73 |
YGL066W |
Subunit of DUBm module of SAGA and SLIK |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
SIP5 |
YMR140W |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
SLX9 |
YGR081C |
Protein required for pre-rRNA processing |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
SNM1 |
YDR478W |
Ribonuclease MRP complex subunit |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
SPO20 |
YMR017W |
Meiosis-specific subunit of the t-SNARE complex |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
SPT21 |
YMR179W |
Protein with a role in transcriptional silencing |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
SSF1 |
YHR066W |
Constituent of 66S pre-ribosomal particles |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
SUP45 |
YBR143C |
Polypeptide release factor (eRF1) in translation termination |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
TFA2 |
YKR062W |
TFIIE small subunit |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
TFB4 |
YPR056W |
Subunit of TFIIH complex |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
TIF6 |
YPR016C |
Constituent of 66S pre-ribosomal particles |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
SUP35 |
YDR172W |
Translation termination factor eRF3 |
genetic |
1 |
1 |
1 |
Positive Genetic |
TRS23 |
YDR246W |
Core component of transport protein particle (TRAPP) complexes I-III |
genetic |
1 |
1 |
1 |
Positive Genetic |
SPC97 |
YHR172W |
Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
SPC24 |
YMR117C |
Component of the kinetochore-associated Ndc80 complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
RDS3 |
YPR094W |
Component of the SF3b subcomplex of the U2 snRNP |
genetic |
1 |
1 |
1 |
Positive Genetic |
RXT2 |
YBR095C |
Component of the histone deacetylase Rpd3L complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
TEF2 |
YBR118W |
Translational elongation factor EF-1 alpha |
genetic |
1 |
1 |
1 |
Positive Genetic |
SLX5 |
YDL013W |
Subunit of the Slx5-Slx8 SUMO-targeted Ub ligase (STUbL) complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
RPN4 |
YDL020C |
Transcription factor that stimulates expression of proteasome genes |
genetic |
1 |
1 |
1 |
Positive Genetic |
RPP2B |
YDR382W |
Ribosomal protein P2 beta |
genetic |
1 |
1 |
1 |
Positive Genetic |
UBR1 |
YGR184C |
E3 ubiquitin ligase (N-recognin) |
genetic |
1 |
1 |
1 |
Positive Genetic |
VPS24 |
YKL041W |
One of four subunits of the ESCRT-III complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
SPE1 |
YKL184W |
Ornithine decarboxylase |
genetic |
1 |
1 |
1 |
Positive Genetic |
RPS0B |
YLR048W |
Protein component of the small (40S) ribosomal subunit |
genetic |
1 |
1 |
1 |
Positive Genetic |
SIC1 |
YLR079W |
Cyclin-dependent kinase inhibitor (CKI) |
genetic |
1 |
1 |
1 |
Positive Genetic |
SIN3 |
YOL004W |
Component of both the Rpd3S and Rpd3L histone deacetylase complexes |
genetic |
1 |
1 |
1 |
Positive Genetic |
TOS7 |
YOL019W |
Protein involved in secretion and cell wall organization |
genetic |
1 |
1 |
1 |
Positive Genetic |
RFC5 |
YBR087W |
Subunit of heteropentameric Replication factor C (RF-C) |
genetic |
1 |
1 |
1 |
Negative Genetic |
TAF5 |
YBR198C |
Subunit (90 kDa) of TFIID and SAGA complexes |
genetic |
1 |
1 |
1 |
Negative Genetic |
TSC13 |
YDL015C |
Enoyl reductase |
genetic |
1 |
1 |
1 |
Negative Genetic |
UBC9 |
YDL064W |
SUMO-conjugating enzyme involved in the Smt3p conjugation pathway |
genetic |
1 |
1 |
1 |
Negative Genetic |
YRB1 |
YDR002W |
Ran GTPase binding protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
SLU7 |
YDR088C |
RNA splicing factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
TFB1 |
YDR311W |
Subunit of TFIIH and nucleotide excision repair factor 3 complexes |
genetic |
1 |
1 |
1 |
Negative Genetic |
PUP3 |
YER094C |
Beta 3 subunit of the 20S proteasome |
genetic |
1 |
1 |
1 |
Negative Genetic |
RSP5 |
YER125W |
NEDD4 family E3 ubiquitin ligase |
genetic |
1 |
1 |
1 |
Negative Genetic |
RNA15 |
YGL044C |
Component of the cleavage and polyadenylation factor I (CF I) |
genetic |
1 |
1 |
1 |
Negative Genetic |
SRM1 |
YGL097W |
Nucleotide exchange factor for Gsp1p |
genetic |
1 |
1 |
1 |
Negative Genetic |
SLD3 |
YGL113W |
Protein involved in the initiation of DNA replication |
genetic |
1 |
1 |
1 |
Negative Genetic |
TAF1 |
YGR274C |
TFIID subunit, involved in RNA pol II transcription initiation |
genetic |
1 |
1 |
1 |
Negative Genetic |
STS1 |
YIR011C |
Protein required for localizing proteasomes to the nucleus |
genetic |
1 |
1 |
1 |
Negative Genetic |
SMC3 |
YJL074C |
Subunit of the multiprotein cohesin complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
POL31 |
YJR006W |
Subunit of DNA polymerase delta (polymerase III) |
genetic |
1 |
1 |
1 |
Negative Genetic |
UGP1 |
YKL035W |
UDP-glucose pyrophosphorylase (UGPase) |
genetic |
1 |
1 |
1 |
Negative Genetic |
TAF13 |
YML098W |
TFIID subunit (19 kDa) |
genetic |
1 |
1 |
1 |
Negative Genetic |
TAF8 |
YML114C |
TFIID subunit (65 kDa) |
genetic |
1 |
1 |
1 |
Negative Genetic |
RSC9 |
YML127W |
Component of the RSC chromatin remodeling complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
TAF4 |
YMR005W |
TFIID subunit (48 kDa) |
genetic |
1 |
1 |
1 |
Negative Genetic |
RNA1 |
YMR235C |
GTPase activating protein (GAP) for Gsp1p |
genetic |
1 |
1 |
1 |
Negative Genetic |
RPC34 |
YNR003C |
RNA polymerase III subunit C34 |
genetic |
1 |
1 |
1 |
Negative Genetic |
RFC4 |
YOL094C |
Subunit of heteropentameric Replication factor C (RF-C) |
genetic |
1 |
1 |
1 |
Negative Genetic |
TOA1 |
YOR194C |
TFIIA large subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
PRT1 |
YOR361C |
eIF3b subunit of the eukaryotic translation initiation factor 3 (eIF3) |
genetic |
1 |
1 |
1 |
Negative Genetic |
SWC3 |
YAL011W |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
RPL19B |
YBL027W |
Ribosomal 60S subunit protein L19B |
genetic |
1 |
1 |
1 |
Negative Genetic |
RPS8A |
YBL072C |
Protein component of the small (40S) ribosomal subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
YBL081W |
YBL081W |
Non-essential protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
YBR238C |
YBR238C |
Mitochondrial membrane protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
PTC6 |
YCR079W |
Mitochondrial type 2C protein phosphatase (PP2C) |
genetic |
1 |
1 |
1 |
Negative Genetic |
RPP1A |
YDL081C |
Ribosomal stalk protein P1 alpha |
genetic |
1 |
1 |
1 |
Negative Genetic |
PPH3 |
YDR075W |
Catalytic subunit of protein phosphatase PP4 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
RPA14 |
YDR156W |
RNA polymerase I subunit A14 |
genetic |
1 |
1 |
1 |
Negative Genetic |
RVS167 |
YDR388W |
Calmodulin-binding actin-associated protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
VPS72 |
YDR485C |
Htz1p-binding component of the SWR1 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
SPT2 |
YER161C |
Protein involved in negative regulation of transcription |
genetic |
1 |
1 |
1 |
Negative Genetic |
SAE2 |
YGL175C |
Endonuclease required for telomere elongation |
genetic |
1 |
1 |
1 |
Negative Genetic |
RTT102 |
YGR275W |
Component of both the SWI/SNF and RSC chromatin remodeling complexes |
genetic |
1 |
1 |
1 |
Negative Genetic |
RPS27B |
YHR021C |
Protein component of the small (40S) ribosomal subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
RPN10 |
YHR200W |
Proteasome polyubiquitin receptor |
genetic |
1 |
1 |
1 |
Negative Genetic |
RPS4B |
YHR203C |
Protein component of the small (40S) ribosomal subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
YIA6 |
YIL006W |
Mitochondrial NAD+ transporter |
genetic |
1 |
1 |
1 |
Negative Genetic |
TED1 |
YIL039W |
GPI-glycan remodelase |
genetic |
1 |
1 |
1 |
Negative Genetic |
SET2 |
YJL168C |
Histone methyltransferase with a role in transcriptional elongation |
genetic |
1 |
1 |
1 |
Negative Genetic |
YKL069W |
YKL069W |
Methionine-R-sulfoxide reductase |
genetic |
1 |
1 |
1 |
Negative Genetic |
SAC1 |
YKL212W |
Phosphatidylinositol phosphate phosphatase |
genetic |
1 |
1 |
1 |
Negative Genetic |
RTT109 |
YLL002W |
Histone acetyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
POM34 |
YLR018C |
Subunit of the transmembrane ring of the nuclear pore complex (NPC) |
genetic |
1 |
1 |
1 |
Negative Genetic |
UBR2 |
YLR024C |
Cytoplasmic ubiquitin-protein ligase (E3) |
genetic |
1 |
1 |
1 |
Negative Genetic |
XDJ1 |
YLR090W |
Chaperone with a role in facilitating mitochondrial protein import |
genetic |
1 |
1 |
1 |
Negative Genetic |
SWI6 |
YLR182W |
Transcription cofactor |
genetic |
1 |
1 |
1 |
Negative Genetic |
TOP3 |
YLR234W |
DNA Topoisomerase III |
genetic |
1 |
1 |
1 |
Negative Genetic |
RPL38 |
YLR325C |
Ribosomal 60S subunit protein L38 |
genetic |
1 |
1 |
1 |
Negative Genetic |
VAC14 |
YLR386W |
Enzyme regulator |
genetic |
1 |
1 |
1 |
Negative Genetic |
STE23 |
YLR389C |
Metalloprotease |
genetic |
1 |
1 |
1 |
Negative Genetic |
SST2 |
YLR452C |
GTPase-activating protein for Gpa1p |
genetic |
1 |
1 |
1 |
Negative Genetic |
YPT7 |
YML001W |
Rab family GTPase |
genetic |
1 |
1 |
1 |
Negative Genetic |
RCO1 |
YMR075W |
Essential component of the Rpd3S histone deacetylase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
SGS1 |
YMR190C |
RecQ family nucleolar DNA helicase |
genetic |
1 |
1 |
1 |
Negative Genetic |
SCS7 |
YMR272C |
Sphingolipid alpha-hydroxylase |
genetic |
1 |
1 |
1 |
Negative Genetic |
YMR315W |
YMR315W |
Protein with NADP(H) oxidoreductase activity |
genetic |
1 |
1 |
1 |
Negative Genetic |
YMR316C-A |
YMR316C-A |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
YOL029C |
YOL029C |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
RTS1 |
YOR014W |
B-type regulatory subunit of protein phosphatase 2A (PP2A) |
genetic |
1 |
1 |
1 |
Negative Genetic |
WHI5 |
YOR083W |
Repressor of G1 transcription |
genetic |
1 |
1 |
1 |
Negative Genetic |
SYC1 |
YOR179C |
Subunit of the APT subcomplex of cleavage and polyadenylation factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
RFM1 |
YOR279C |
Component of the Sum1p-Rfm1p-Hst1p complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
YOR289W |
YOR289W |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
RMI1 |
YPL024W |
Subunit of the RecQ (Sgs1p) - Topo III (Top3p) complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
RPS6A |
YPL090C |
Protein component of the small (40S) ribosomal subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
RPL43A |
YPR043W |
Ribosomal 60S subunit protein L43A |
genetic |
1 |
1 |
1 |
Negative Genetic |
RPS23B |
YPR132W |
Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
SML1 |
YML058W |
Ribonucleotide reductase inhibitor |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
RTG3 |
YBL103C |
bHLH/Zip transcription factor for retrograde (RTG) and TOR pathways |
genetic |
1 |
1 |
1 |
Negative Genetic |
REB1 |
YBR049C |
RNA polymerase I enhancer binding protein |
genetic |
1 |
1 |
1 |
Positive Genetic |
RAD14 |
YMR201C |
Subunit of Nucleotide Excision Repair Factor 1 (NEF1) |
genetic |
1 |
1 |
1 |
Positive Genetic |
URA7 |
YBL039C |
Major CTP synthase isozyme (see also URA8) |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
YKU70 |
YMR284W |
Subunit of the telomeric Ku complex (Yku70p-Yku80p) |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
RNR1 |
YER070W |
Major isoform of large subunit of ribonucleotide-diphosphate reductase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
BUD21 |
YOR078W |
Component of small ribosomal subunit (SSU) processosome |
genetic |
1 |
1 |
1 |
Negative Genetic |
HTA2 |
YBL003C |
Histone H2A |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
PDC1 |
YLR044C |
Major of three pyruvate decarboxylase isozymes |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
DEP1 |
YAL013W |
Component of the Rpd3L histone deacetylase complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
MAF1 |
YDR005C |
Highly conserved negative regulator of RNA polymerase III |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
NUP85 |
YJR042W |
Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) |
genetic |
1 |
1 |
1 |
Negative Genetic |
HOS2 |
YGL194C |
Histone deacetylase and subunit of Set3 and Rpd3L complexes |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
CDC25 |
YLR310C |
Membrane bound guanine nucleotide exchange factor |
genetic |
1 |
1 |
1 |
Positive Genetic |
INP52 |
YNL106C |
Polyphosphatidylinositol phosphatase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
NEM1 |
YHR004C |
Probable catalytic subunit of Nem1p-Spo7p phosphatase holoenzyme |
genetic |
1 |
1 |
1 |
Negative Genetic |
HEM13 |
YDR044W |
Coproporphyrinogen III oxidase |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
CCT6 |
YDR188W |
Subunit of the cytosolic chaperonin Cct ring complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
MCM2 |
YBL023C |
Protein involved in DNA replication |
genetic |
1 |
1 |
1 |
Negative Genetic |
FLC2 |
YAL053W |
Putative calcium channel involved in calcium release under hypotonic |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
BRE2 |
YLR015W |
Subunit of COMPASS (Set1C) complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
GET3 |
YDL100C |
Guanine nucleotide exchange factor for Gpa1p |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
LAP2 |
YNL045W |
Leucyl aminopeptidase yscIV with epoxide hydrolase activity |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
CDC13 |
YDL220C |
Single stranded DNA-binding protein found at TG1-3 telomere G-tails |
genetic |
1 |
1 |
1 |
Negative Genetic |
LSP1 |
YPL004C |
Eisosome core component |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
PHO84 |
YML123C |
High-affinity inorganic phosphate (Pi) transporter |
genetic |
1 |
1 |
1 |
Negative Genetic |
FIN1 |
YDR130C |
Spindle pole body-related intermediate filament protein |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
NGL2 |
YMR285C |
Protein involved in 5.8S rRNA processing |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
IRA2 |
YOL081W |
GTPase-activating protein |
genetic |
1 |
1 |
1 |
Positive Genetic |
PHO85 |
YPL031C |
Cyclin-dependent kinase |
physical |
1 |
1 |
1 |
Biochemical Activity |
CAF20 |
YOR276W |
Phosphoprotein of the mRNA cap-binding complex |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
BUB2 |
YMR055C |
Mitotic exit network regulator |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
HTB1 |
YDR224C |
Histone H2B |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
HTB1 |
YDR224C |
Histone H2B |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
HIR3 |
YJR140C |
Subunit of the HIR complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
GSP1 |
YLR293C |
Ran GTPase |
genetic |
1 |
1 |
1 |
Negative Genetic |
BFA1 |
YJR053W |
Subunit of a two-component GTPase-activating protein, Bfa1p-Bub2p |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
CMK1 |
YFR014C |
Calmodulin-dependent protein kinase |
physical |
1 |
1 |
1 |
Biochemical Activity |
COF1 |
YLL050C |
Cofilin, involved in pH-dependent actin filament depolarization |
genetic |
1 |
1 |
1 |
Negative Genetic |
INM1 |
YHR046C |
Inositol monophosphatase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
MLH3 |
YPL164C |
Protein involved in DNA mismatch repair and meiotic recombination |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
CDC20 |
YGL116W |
Activator of anaphase-promoting complex/cyclosome (APC/C) |
genetic |
1 |
1 |
1 |
Negative Genetic |
KAP122 |
YGL016W |
Karyopherin beta |
genetic |
1 |
1 |
1 |
Negative Genetic |
PDS1 |
YDR113C |
Securin |
genetic |
1 |
1 |
1 |
Negative Genetic |
CAT5 |
YOR125C |
Protein required for ubiquinone (Coenzyme Q) biosynthesis |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
ETP1 |
YHL010C |
Protein of unknown function required for growth on ethanol |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
HUL5 |
YGL141W |
Multiubiquitin chain assembly factor (E4) |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
DNL4 |
YOR005C |
DNA ligase required for nonhomologous end-joining (NHEJ) |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
PDX1 |
YGR193C |
E3-binding protein of the mitochondrial pyruvate dehydrogenase complex |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
CDC15 |
YAR019C |
Hippo-like kinase of the Mitotic Exit Network |
genetic |
1 |
1 |
1 |
Positive Genetic |
HIR2 |
YOR038C |
Subunit of HIR nucleosome assembly complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
HHT1 |
YBR010W |
Histone H3 |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
HHT1 |
YBR010W |
Histone H3 |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
CTF4 |
YPR135W |
Chromatin-associated protein |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
ICP55 |
YER078C |
Mitochondrial aminopeptidase |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
CLB2 |
YPR119W |
B-type cyclin involved in cell cycle progression |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
NUP2 |
YLR335W |
Nucleoporin involved in nucleocytoplasmic transport |
genetic |
1 |
1 |
1 |
Negative Genetic |
ELG1 |
YOR144C |
Subunit of an alternative replication factor C complex |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
NDE1 |
YMR145C |
Mitochondrial external NADH dehydrogenase |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
FAL1 |
YDR021W |
Nucleolar protein required for maturation of 18S rRNA |
genetic |
1 |
1 |
1 |
Negative Genetic |
BTN2 |
YGR142W |
v-SNARE binding protein |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
CIA1 |
YDR267C |
Component of cytosolic iron-sulfur protein assembly (CIA) machinery |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
BUB3 |
YOR026W |
Kinetochore checkpoint WD40 repeat protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
MMS4 |
YBR098W |
Subunit of structure-specific Mms4p-Mus81p endonuclease |
genetic |
1 |
1 |
1 |
Negative Genetic |
HOM2 |
YDR158W |
Aspartic beta semi-aldehyde dehydrogenase |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
EXO70 |
YJL085W |
Subunit of the exocyst complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
ERG11 |
YHR007C |
Lanosterol 14-alpha-demethylase |
genetic |
1 |
1 |
1 |
Positive Genetic |
NUP133 |
YKR082W |
Subunit of Nup84p subcomplex of nuclear pore complex (NPC) |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
MMS22 |
YLR320W |
Subunit of E3 ubiquitin ligase complex involved in replication repair |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
MLP2 |
YIL149C |
Myosin-like protein associated with the nuclear envelope |
genetic |
1 |
1 |
1 |
Positive Genetic |
DAD1 |
YDR016C |
Essential subunit of the Dam1 complex (aka DASH complex) |
genetic |
1 |
1 |
1 |
Positive Genetic |
BUD27 |
YFL023W |
Unconventional prefoldin protein involved in translation initiation |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
ATG16 |
YMR159C |
Conserved protein involved in autophagy |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
CSM1 |
YCR086W |
Nucleolar protein that mediates homolog segregation during meiosis I |
genetic |
1 |
1 |
1 |
Negative Genetic |
MCM10 |
YIL150C |
Essential chromatin-associated protein |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
INO2 |
YDR123C |
Transcription factor |
genetic |
1 |
1 |
1 |
Positive Genetic |
MOB2 |
YFL034C-B |
Activator of Cbk1p kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
MSN5 |
YDR335W |
Karyopherin |
genetic |
1 |
1 |
1 |
Positive Genetic |
NUP57 |
YGR119C |
FG-nucleoporin component of central core of the nuclear pore complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
MND2 |
YIR025W |
Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) |
genetic |
1 |
1 |
1 |
Negative Genetic |
PBY1 |
YBR094W |
Putative tubulin tyrosine ligase associated with P-bodies |
genetic |
1 |
1 |
1 |
Negative Genetic |
BAS1 |
YKR099W |
Myb-related transcription factor |
genetic |
1 |
1 |
1 |
Positive Genetic |
DAS2 |
YDR020C |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
PIR5 |
YJL160C |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
MGL2 |
YMR210W |
Monoacylglycerol and triacylglycerol lipase |
genetic |
1 |
1 |
1 |
Negative Genetic |
MDY2 |
YOL111C |
Protein involved in inserting tail-anchored proteins into ER membranes |
genetic |
1 |
1 |
1 |
Positive Genetic |
NST1 |
YNL091W |
Translational inhibitor and suppressor of proteasome-assembly defects |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
FMP40 |
YPL222W |
Mitochondrial AMPylator in the pseudokinase selenoprotein-O family |
genetic |
1 |
1 |
1 |
Negative Genetic |
APC4 |
YDR118W |
Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
ELP3 |
YPL086C |
Subunit of Elongator complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
PEX2 |
YJL210W |
RING-finger peroxin and E3 ubiquitin ligase |
genetic |
1 |
1 |
1 |
Negative Genetic |
DAL81 |
YIR023W |
Positive regulator of genes in multiple nitrogen degradation pathways |
genetic |
1 |
1 |
1 |
Negative Genetic |
HPC2 |
YBR215W |
Subunit of the HIR complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
BRN1 |
YBL097W |
Subunit of the condensin complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
BUB1 |
YGR188C |
Protein kinase involved in the cell cycle checkpoint into anaphase |
genetic |
1 |
1 |
1 |
Negative Genetic |
DBF4 |
YDR052C |
Regulatory subunit of Cdc7p-Dbf4p kinase complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
EPS1 |
YIL005W |
ER protein with chaperone and co-chaperone activity |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
GIM4 |
YEL003W |
Subunit of the heterohexameric cochaperone prefoldin complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
ECO1 |
YFR027W |
Acetyltransferase required for sister chromatid cohesion |
genetic |
1 |
1 |
1 |
Negative Genetic |
MAD1 |
YGL086W |
Coiled-coil protein involved in spindle-assembly checkpoint |
genetic |
1 |
1 |
1 |
Negative Genetic |
MCM3 |
YEL032W |
Protein involved in DNA replication |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
ORC3 |
YLL004W |
Subunit of the origin recognition complex (ORC) |
genetic |
1 |
1 |
1 |
Negative Genetic |
OST3 |
YOR085W |
Gamma subunit of the oligosaccharyltransferase complex of the ER lumen |
genetic |
1 |
1 |
1 |
Positive Genetic |
PAN1 |
YIR006C |
Part of actin cytoskeleton-regulatory complex Pan1p-Sla1p-End3p |
genetic |
1 |
1 |
1 |
Negative Genetic |
DPH2 |
YKL191W |
Protein required for synthesis of diphthamide |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
GLN3 |
YER040W |
Transcriptional activator in nitrogen catabolite repression system |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
MOB1 |
YIL106W |
Component of the mitotic exit network |
genetic |
1 |
1 |
1 |
Negative Genetic |
BAG7 |
YOR134W |
Rho GTPase activating protein (RhoGAP) |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
CSG2 |
YBR036C |
Endoplasmic reticulum membrane protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
EMC5 |
YIL027C |
Member of conserved ER transmembrane complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
MCM7 |
YBR202W |
Component of the Mcm2-7 hexameric helicase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
ESC2 |
YDR363W |
Sumo-like domain protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
DPH6 |
YLR143W |
Diphthamide synthetase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
CDC19 |
YAL038W |
Pyruvate kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
MET32 |
YDR253C |
Zinc-finger DNA-binding transcription factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
MKK1 |
YOR231W |
MAPKK involved in the protein kinase C signaling pathway |
genetic |
1 |
1 |
1 |
Negative Genetic |
AZF1 |
YOR113W |
Zinc-finger transcription factor |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
PBP1 |
YGR178C |
Component of glucose deprivation induced stress granules |
genetic |
1 |
1 |
1 |
Negative Genetic |
CHS5 |
YLR330W |
Component of the exomer complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
HHT2 |
YNL031C |
Histone H3 |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
APN2 |
YBL019W |
Class II abasic (AP) endonuclease involved in repair of DNA damage |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
HOC1 |
YJR075W |
Alpha-1,6-mannosyltransferase |
genetic |
1 |
1 |
1 |
Positive Genetic |
EIS1 |
YMR031C |
Component of the eisosome required for proper eisosome assembly |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
MID1 |
YNL291C |
Stretch-activated Ca2+-permeable cation channel |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
DBP6 |
YNR038W |
Essential protein involved in ribosome biogenesis |
genetic |
1 |
1 |
1 |
Negative Genetic |
MIT1 |
YEL007W |
Transcriptional regulator of pseudohyphal growth |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
GPB1 |
YOR371C |
Multistep regulator of cAMP-PKA signaling |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
HCM1 |
YCR065W |
Forkhead transcription factor |
genetic |
1 |
1 |
1 |
Positive Genetic |
ALG1 |
YBR110W |
Mannosyltransferase |
genetic |
1 |
1 |
1 |
Positive Genetic |
MMS1 |
YPR164W |
Subunit of E3 ubiquitin ligase complex involved in replication repair |
genetic |
1 |
1 |
1 |
Positive Genetic |
ORC6 |
YHR118C |
Subunit of the origin recognition complex (ORC) |
genetic |
1 |
1 |
1 |
Negative Genetic |
ESBP6 |
YNL125C |
Protein with similarity to monocarboxylate permeases |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
GPI2 |
YPL076W |
Protein involved in the synthesis of GlcNAc-PI |
genetic |
1 |
1 |
1 |
Negative Genetic |
IRC7 |
YFR055W |
Cysteine desulphydrase, enables growth on cysteine as nitrogen source |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
BPH1 |
YCR032W |
Protein homologous to Chediak-Higashi syndrome and Beige proteins |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
NTH1 |
YDR001C |
Neutral trehalase, degrades trehalose |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
GLO2 |
YDR272W |
Cytoplasmic glyoxalase II |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
AIM22 |
YJL046W |
Lipoate-protein ligase |
genetic |
1 |
1 |
1 |
Positive Genetic |
PDC2 |
YDR081C |
Transcription factor for thiamine-regulated genes |
genetic |
1 |
1 |
1 |
Negative Genetic |
BRL1 |
YHR036W |
Essential nuclear envelope/ER integral membrane protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
MTC1 |
YJL123C |
Protein of unknown function that may interact with ribosomes |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
GEP7 |
YGL057C |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
PMR1 |
YGL167C |
High affinity Ca2+/Mn2+ P-type ATPase |
genetic |
1 |
1 |
1 |
Negative Genetic |
IMP21 |
YIL154C |
Transcriptional activator involved in maintenance of ion homeostasis |
genetic |
1 |
1 |
1 |
Negative Genetic |
ORC4 |
YPR162C |
Subunit of the origin recognition complex (ORC) |
genetic |
1 |
1 |
1 |
Negative Genetic |
KIN4 |
YOR233W |
Serine/threonine protein kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
LAM1 |
YHR155W |
Putative sterol transfer protein |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
ELF1 |
YKL160W |
Transcription elongation factor with a conserved zinc finger domain |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
CYK3 |
YDL117W |
SH3-domain protein located in the bud neck and cytokinetic actin ring |
genetic |
1 |
1 |
1 |
Negative Genetic |
HFD1 |
YMR110C |
Dehydrogenase involved in ubiquinone and sphingolipid metabolism |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
POC4 |
YPL144W |
Component of a heterodimeric Poc4p-Irc25p chaperone |
genetic |
1 |
1 |
1 |
Positive Genetic |
PEX32 |
YBR168W |
Peroxisomal integral membrane protein |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
PET130 |
YJL023C |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
ABZ2 |
YMR289W |
Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase) |
genetic |
1 |
1 |
1 |
Negative Genetic |
CSA1 |
YPR174C |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
NUP192 |
YJL039C |
Essential subunit of inner ring of nuclear pore complex (NPC) |
genetic |
1 |
1 |
1 |
Negative Genetic |
DPH5 |
YLR172C |
Methyltransferase required for synthesis of diphthamide |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
ARO2 |
YGL148W |
Bifunctional chorismate synthase and flavin reductase |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
APJ1 |
YNL077W |
Hsp40 chaperone with a role in SUMO-mediated protein degradation |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
ATG21 |
YPL100W |
Phosphoinositide binding protein |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
CMK2 |
YOL016C |
Calmodulin-dependent protein kinase |
physical |
1 |
1 |
1 |
Biochemical Activity |
DEG1 |
YFL001W |
tRNA:pseudouridine synthase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
IRC5 |
YFR038W |
Putative ATPase containing the DEAD/H helicase-related sequence motif |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
ORM1 |
YGR038W |
Protein that mediates sphingolipid homeostasis |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
HUR1 |
YGL168W |
Protein with a role in DNA repair |
genetic |
1 |
1 |
1 |
Negative Genetic |
ALG6 |
YOR002W |
ER-luminal alpha 1,3 glucosyltransferase |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
CYT1 |
YOR065W |
Cytochrome c1 |
genetic |
1 |
1 |
1 |
Positive Genetic |
GPI19 |
YDR437W |
Subunit of GPI-GlcNAc transferase involved in synthesis of GlcNAc-PI |
genetic |
1 |
1 |
1 |
Negative Genetic |
DCR2 |
YLR361C |
Protein phosphatase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
GUT2 |
YIL155C |
Mitochondrial glycerol-3-phosphate dehydrogenase |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
JJJ3 |
YJR097W |
Iron-binding protein |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
NCB2 |
YDR397C |
Subunit of a heterodimeric NC2 transcription regulator complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
DFG16 |
YOR030W |
Probable multiple transmembrane protein |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
MSA1 |
YOR066W |
Activator of G1-specific transcription factors MBF and SBF |
genetic |
1 |
1 |
1 |
Dosage Rescue |
NEO1 |
YIL048W |
Phospholipid translocase (flippase) |
genetic |
1 |
1 |
1 |
Positive Genetic |
ILM1 |
YJR118C |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
ALG7 |
YBR243C |
UDP-N-acetyl-glucosamine-1-P transferase |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
FLC1 |
YPL221W |
Flavin adenine dinucleotide transporter |
genetic |
1 |
1 |
1 |
Positive Genetic |
MRL1 |
YPR079W |
Membrane protein |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
ERP6 |
YGL002W |
Member of the p24 family involved in ER to Golgi transport |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
ERG3 |
YLR056W |
C-5 sterol desaturase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
MRN1 |
YPL184C |
RNA-binding protein that may be involved in translational regulation |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
BRR6 |
YGL247W |
Essential nuclear envelope integral membrane protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
CDC8 |
YJR057W |
Nucleoside monophosphate and nucleoside diphosphate kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
FIT2 |
YOR382W |
Mannoprotein that is incorporated into the cell wall |
genetic |
1 |
1 |
1 |
Negative Genetic |
FLO1 |
YAR050W |
Lectin-like protein involved in flocculation |
genetic |
1 |
1 |
1 |
Negative Genetic |
FLC3 |
YGL139W |
Putative FAD transporter, similar to Flc1p and Flc2p |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
FKS3 |
YMR306W |
Protein involved in spore wall assembly |
genetic |
1 |
1 |
1 |
Negative Genetic |
ATO2 |
YNR002C |
Putative transmembrane protein involved in export of ammonia |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
AIM14 |
YGL160W |
NADPH oxidase localized to the perinuclear ER |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
NCS6 |
YGL211W |
Protein required for uridine thiolation of Gln, Lys, and Glu tRNAs |
genetic |
1 |
1 |
1 |
Positive Genetic |
MTC3 |
YGL226W |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Positive Genetic |
MDL2 |
YPL270W |
Mitochondrial inner membrane half-type ABC transporter |
genetic |
1 |
1 |
1 |
Negative Genetic |
GPI15 |
YNL038W |
Protein involved in the synthesis of GlcNAc-PI |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
CDC1 |
YDR182W |
Putative mannose-ethanolamine phosphate phosphodiesterase |
genetic |
1 |
1 |
1 |
Positive Genetic |
HEM3 |
YDL205C |
Porphobilinogen deaminase |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
FLX1 |
YIL134W |
Mitochondrial flavin adenine dinucleotide transporter |
genetic |
1 |
1 |
1 |
Negative Genetic |
PER1 |
YCR044C |
Protein of the endoplasmic reticulum |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
JEN1 |
YKL217W |
Monocarboxylate/proton symporter of the plasma membrane |
genetic |
1 |
1 |
1 |
Negative Genetic |
MMM1 |
YLL006W |
ER integral membrane protein, ERMES complex subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
PHO5 |
YBR093C |
Repressible acid phosphatase |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
PKP1 |
YIL042C |
Mitochondrial protein kinase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
PIF1 |
YML061C |
DNA helicase, potent G-quadruplex DNA binder/unwinder |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
OAR1 |
YKL055C |
Mitochondrial 3-oxoacyl-[acyl-carrier-protein] reductase |
genetic |
1 |
1 |
1 |
Positive Genetic |
ILT1 |
YDR090C |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
MSH1 |
YHR120W |
DNA-binding protein of the mitochondria |
genetic |
1 |
1 |
1 |
Negative Genetic |
GPI11 |
YDR302W |
ER membrane protein involved in a late step of GPI anchor assembly |
genetic |
1 |
1 |
1 |
Negative Genetic |
DBR1 |
YKL149C |
RNA lariat debranching enzyme |
genetic |
1 |
1 |
1 |
Negative Genetic |
PCP1 |
YGR101W |
Mitochondrial serine protease |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
MTC4 |
YBR255W |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |