SRS2 |
YJL092W |
DNA helicase and DNA-dependent ATPase |
genetic |
8 |
4 |
7 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Dosage Lethality, Negative Genetic, Negative Genetic |
RRM3 |
YHR031C |
DNA helicase involved in rDNA replication and Ty1 transposition |
genetic |
8 |
3 |
6 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Lethality, Negative Genetic, Negative Genetic |
SGS1 |
YMR190C |
RecQ family nucleolar DNA helicase |
genetic |
7 |
4 |
7 |
Synthetic Growth Defect, Phenotypic Suppression, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement, Negative Genetic, Negative Genetic |
MRC1 |
YCL061C |
S-phase checkpoint protein required for DNA replication |
genetic |
7 |
2 |
6 |
Positive Genetic, Positive Genetic, Positive Genetic, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Positive Genetic |
HSL1 |
YKL101W |
Nim1p-related protein kinase |
genetic |
7 |
1 |
5 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
TSA1 |
YML028W |
Thioredoxin peroxidase |
genetic |
6 |
2 |
4 |
Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic |
RAD27 |
YKL113C |
5' to 3' exonuclease, 5' flap endonuclease |
genetic |
6 |
2 |
4 |
Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic |
HUR1 |
YGL168W |
Protein with a role in DNA repair |
genetic |
6 |
2 |
4 |
Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic |
RAD51 |
YER095W |
Strand exchange protein |
genetic |
5 |
4 |
3 |
Phenotypic Suppression, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic |
PMR1 |
YGL167C |
High affinity Ca2+/Mn2+ P-type ATPase |
genetic |
5 |
2 |
3 |
Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic |
CLA4 |
YNL298W |
Cdc42p-activated signal transducing kinase |
genetic |
4 |
2 |
4 |
Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic |
RTT101 |
YJL047C |
Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex |
physical |
4 |
2 |
3 |
Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS |
MMS22 |
YLR320W |
Subunit of E3 ubiquitin ligase complex involved in replication repair |
physical |
4 |
2 |
3 |
Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western |
POL3 |
YDL102W |
Catalytic subunit of DNA polymerase delta |
genetic |
4 |
2 |
3 |
Phenotypic Enhancement, Negative Genetic, Negative Genetic, Negative Genetic |
RAD52 |
YML032C |
Protein involved in homologous recombination |
genetic |
4 |
2 |
3 |
Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic |
SKN7 |
YHR206W |
Nuclear response regulator and transcription factor |
genetic |
4 |
2 |
3 |
Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic |
YAP1 |
YML007W |
Basic leucine zipper (bZIP) transcription factor |
genetic |
4 |
2 |
3 |
Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic |
SLX8 |
YER116C |
Subunit of Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex |
genetic |
4 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
SLX5 |
YDL013W |
Subunit of the Slx5-Slx8 SUMO-targeted Ub ligase (STUbL) complex |
genetic |
4 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
ESA1 |
YOR244W |
Catalytic subunit of the histone acetyltransferase complex (NuA4) |
genetic |
4 |
1 |
2 |
Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect |
RTT107 |
YHR154W |
BRCA1 C-terminal domain protein needed for recovery from DNA damage |
physical |
3 |
3 |
3 |
Affinity Capture-Western, Affinity Capture-MS, Two-hybrid |
RAD59 |
YDL059C |
Protein involved DNA double-strand break repair |
genetic |
3 |
3 |
3 |
Phenotypic Enhancement, Synthetic Growth Defect, Negative Genetic |
MAG1 |
YER142C |
3-methyl-adenine DNA glycosylase |
genetic |
3 |
2 |
3 |
Phenotypic Enhancement, Positive Genetic, Positive Genetic |
DST1 |
YGL043W |
General transcription elongation factor TFIIS |
genetic |
3 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic |
PPH3 |
YDR075W |
Catalytic subunit of protein phosphatase PP4 complex |
genetic |
3 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic |
SLX4 |
YLR135W |
Endonuclease involved in processing DNA |
genetic |
3 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic |
RAD57 |
YDR004W |
Protein that stimulates strand exchange |
genetic |
3 |
3 |
2 |
Synthetic Growth Defect, Negative Genetic, Positive Genetic |
RAD18 |
YCR066W |
E3 ubiquitin ligase |
genetic |
3 |
3 |
2 |
Synthetic Growth Defect, Negative Genetic, Positive Genetic |
MMS4 |
YBR098W |
Subunit of structure-specific Mms4p-Mus81p endonuclease |
genetic |
3 |
3 |
2 |
Synthetic Growth Defect, Negative Genetic, Positive Genetic |
MPH1 |
YIR002C |
3'-5' DNA helicase involved in error-free bypass of DNA lesions |
genetic |
3 |
3 |
2 |
Dosage Lethality, Negative Genetic, Positive Genetic |
DNA2 |
YHR164C |
ATP-dependent 5'-flap endonuclease and DNA helicase |
genetic |
3 |
2 |
2 |
Synthetic Lethality, Negative Genetic, Negative Genetic |
CCS1 |
YMR038C |
Copper chaperone for superoxide dismutase Sod1p |
genetic |
3 |
2 |
2 |
Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect |
RAD50 |
YNL250W |
Subunit of MRX complex with Mre11p and Xrs2p |
genetic |
3 |
2 |
2 |
Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect |
XRS2 |
YDR369C |
FHA domain-containing component of the Mre11 complex |
genetic |
3 |
2 |
2 |
Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect |
RAD9 |
YDR217C |
DNA damage-dependent checkpoint protein |
genetic |
3 |
2 |
2 |
Phenotypic Suppression, Phenotypic Enhancement, Phenotypic Enhancement |
EAF1 |
YDR359C |
Component of the NuA4 histone acetyltransferase complex |
genetic |
3 |
1 |
2 |
Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect |
HOM6 |
YJR139C |
Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase) |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
RNH202 |
YDR279W |
Ribonuclease H2 subunit |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
LST4 |
YKL176C |
Subunit of the Lst4p-Lst7p GTPase activating protein complex for Gtr2p |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
ESC2 |
YDR363W |
Sumo-like domain protein |
physical |
3 |
2 |
1 |
Two-hybrid, Affinity Capture-Western, Affinity Capture-Western |
CDC73 |
YLR418C |
Component of the Paf1p complex |
genetic |
2 |
2 |
2 |
Negative Genetic, Synthetic Growth Defect |
ESP1 |
YGR098C |
Separase/separin, a caspase-like cysteine protease |
genetic |
2 |
2 |
2 |
Negative Genetic, Synthetic Growth Defect |
CRM1 |
YGR218W |
Nuclear export factor, exportin |
physical |
2 |
2 |
2 |
Two-hybrid, Affinity Capture-MS |
HTZ1 |
YOL012C |
Histone variant H2AZ |
genetic |
2 |
2 |
2 |
Positive Genetic, Synthetic Growth Defect |
LTE1 |
YAL024C |
Protein similar to GDP/GTP exchange factors |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Negative Genetic |
GET2 |
YER083C |
Subunit of the GET complex |
genetic |
2 |
2 |
2 |
Negative Genetic, Synthetic Growth Defect |
RTT107 |
YHR154W |
BRCA1 C-terminal domain protein needed for recovery from DNA damage |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Negative Genetic |
RAD6 |
YGL058W |
Ubiquitin-conjugating enzyme (E2) |
genetic |
2 |
2 |
2 |
Phenotypic Enhancement, Synthetic Growth Defect |
TOP1 |
YOL006C |
Topoisomerase I |
genetic |
2 |
2 |
2 |
Phenotypic Suppression, Synthetic Growth Defect |
POL30 |
YBR088C |
Proliferating cell nuclear antigen (PCNA) |
genetic |
2 |
2 |
2 |
Negative Genetic, Synthetic Growth Defect |
SOD1 |
YJR104C |
Cytosolic copper-zinc superoxide dismutase |
genetic |
2 |
2 |
2 |
Negative Genetic, Synthetic Lethality |
POL32 |
YJR043C |
Third subunit of DNA polymerase delta |
genetic |
2 |
2 |
2 |
Positive Genetic, Synthetic Rescue |
SAS2 |
YMR127C |
Histone acetyltransferase (HAT) catalytic subunit of the SAS complex |
genetic |
2 |
2 |
2 |
Positive Genetic, Phenotypic Enhancement |
POB3 |
YML069W |
Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) |
genetic |
2 |
2 |
2 |
Synthetic Rescue, Negative Genetic |
RAD55 |
YDR076W |
Protein that stimulates strand exchange |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Positive Genetic |
RAD54 |
YGL163C |
DNA-dependent ATPase that stimulates strand exchange |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Positive Genetic |
SMT3 |
YDR510W |
Ubiquitin-like protein of the SUMO family |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Negative Genetic |
ACT1 |
YFL039C |
Actin, structural protein in cytoskeleton |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
HRT1 |
YOL133W |
RING-H2 domain core subunit of multiple ubiquitin ligase complexes |
physical |
2 |
1 |
2 |
Affinity Capture-MS, Affinity Capture-MS |
CIK1 |
YMR198W |
Kinesin-associated protein |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
ELG1 |
YOR144C |
Subunit of an alternative replication factor C complex |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
RTT101 |
YJL047C |
Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex |
genetic |
2 |
1 |
2 |
Positive Genetic, Positive Genetic |
MMS22 |
YLR320W |
Subunit of E3 ubiquitin ligase complex involved in replication repair |
genetic |
2 |
1 |
2 |
Positive Genetic, Positive Genetic |
SAC1 |
YKL212W |
Phosphatidylinositol phosphate phosphatase |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
RTS1 |
YOR014W |
B-type regulatory subunit of protein phosphatase 2A (PP2A) |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
PSY2 |
YNL201C |
Subunit of protein phosphatase PP4 complex |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
ORC2 |
YBR060C |
Subunit of the origin recognition complex (ORC) |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
YKL069W |
YKL069W |
Methionine-R-sulfoxide reductase |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
PMS1 |
YNL082W |
ATP-binding protein required for mismatch repair |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
TAP42 |
YMR028W |
Essential protein involved in the TOR signaling pathway |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
HRQ1 |
YDR291W |
3'-5' DNA helicase of the conserved RecQ family |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
ILM1 |
YJR118C |
Protein of unknown function |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
CCR4 |
YAL021C |
Component of the CCR4-NOT transcriptional complex |
genetic |
2 |
2 |
1 |
Synthetic Lethality, Synthetic Growth Defect |
HST3 |
YOR025W |
Sirtuin, histone H3 deacetylase |
genetic |
2 |
2 |
1 |
Positive Genetic, Synthetic Rescue |
ECO1 |
YFR027W |
Acetyltransferase required for sister chromatid cohesion |
genetic |
2 |
2 |
1 |
Synthetic Lethality, Dosage Rescue |
ORC5 |
YNL261W |
Subunit of the origin recognition complex (ORC) |
physical |
2 |
2 |
1 |
Two-hybrid, Affinity Capture-Western |
POP2 |
YNR052C |
Subunit of Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation |
genetic |
2 |
2 |
1 |
Synthetic Growth Defect, Synthetic Lethality |
MUS81 |
YDR386W |
Subunit of structure-specific Mms4p-Mus81p endonuclease |
genetic |
2 |
2 |
1 |
Negative Genetic, Positive Genetic |
MAK16 |
YAL025C |
Essential nuclear protein |
genetic |
2 |
1 |
1 |
Positive Genetic, Positive Genetic |
ASF1 |
YJL115W |
Nucleosome assembly factor |
genetic |
2 |
1 |
1 |
Synthetic Growth Defect, Synthetic Growth Defect |
CDC28 |
YBR160W |
Cyclin-dependent kinase (CDK) catalytic subunit |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
DYN1 |
YKR054C |
Cytoplasmic heavy chain dynein |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
CDC20 |
YGL116W |
Activator of anaphase-promoting complex/cyclosome (APC/C) |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
HHT1 |
YBR010W |
Histone H3 |
genetic |
2 |
1 |
1 |
Synthetic Lethality, Synthetic Lethality |
DIA2 |
YOR080W |
Origin-binding F-box protein |
genetic |
2 |
1 |
1 |
Synthetic Growth Defect, Synthetic Growth Defect |
DBF4 |
YDR052C |
Regulatory subunit of Cdc7p-Dbf4p kinase complex |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
PPM1 |
YDR435C |
Carboxyl methyltransferase |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
MRE11 |
YMR224C |
Nuclease subunit of the MRX complex with Rad50p and Xrs2p |
genetic |
2 |
1 |
1 |
Synthetic Growth Defect, Synthetic Growth Defect |
UBC9 |
YDL064W |
SUMO-conjugating enzyme involved in the Smt3p conjugation pathway |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
POL31 |
YJR006W |
Subunit of DNA polymerase delta (polymerase III) |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
SEN1 |
YLR430W |
ATP-dependent 5' to 3' RNA/DNA and DNA helicase |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
IRC5 |
YFR038W |
Putative ATPase containing the DEAD/H helicase-related sequence motif |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
CRT10 |
YOL063C |
Protein required for the degradation of mutant 25S rRNAs |
physical |
2 |
1 |
1 |
Affinity Capture-MS, Affinity Capture-MS |
FKH1 |
YIL131C |
Forkhead family transcription factor |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
XBP1 |
YIL101C |
Transcriptional repressor |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
YAP1 |
YML007W |
Basic leucine zipper (bZIP) transcription factor |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
REB1 |
YBR049C |
RNA polymerase I enhancer binding protein |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
YAP5 |
YIR018W |
Basic leucine zipper (bZIP) iron-sensing transcription factor |
regulation |
1 |
1 |
1 |
DNA to cDNA expression microarray evidence |
UME6 |
YDR207C |
Rpd3L histone deacetylase complex subunit |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
CDC73 |
YLR418C |
Component of the Paf1p complex |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
CHD1 |
YER164W |
Chromatin remodeler that regulates various aspects of transcription |
genetic |
1 |
1 |
1 |
Positive Genetic |
CTR9 |
YOL145C |
Component of the Paf1p complex involved in transcription elongation |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
LEO1 |
YOR123C |
Component of the Paf1 complex |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
HAS1 |
YMR290C |
ATP-dependent RNA helicase |
genetic |
1 |
1 |
1 |
Negative Genetic |
BRE1 |
YDL074C |
E3 ubiquitin ligase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
MAK21 |
YDR060W |
Constituent of 66S pre-ribosomal particles |
genetic |
1 |
1 |
1 |
Negative Genetic |
MDM20 |
YOL076W |
Non-catalytic subunit of the NatB N-terminal acetyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
LSM1 |
YJL124C |
Lsm (Like Sm) protein |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
LSM6 |
YDR378C |
Lsm (Like Sm) protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
CDC48 |
YDL126C |
AAA ATPase with protein-unfoldase activity |
genetic |
1 |
1 |
1 |
Negative Genetic |
CSL4 |
YNL232W |
Exosome non-catalytic core component |
genetic |
1 |
1 |
1 |
Negative Genetic |
CCR4 |
YAL021C |
Component of the CCR4-NOT transcriptional complex |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
ARP3 |
YJR065C |
Essential component of the Arp2/3 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
BET3 |
YKR068C |
Core component of transport protein particle (TRAPP) complexes I-III |
genetic |
1 |
1 |
1 |
Positive Genetic |
ASC1 |
YMR116C |
G-protein beta subunit and guanine dissociation inhibitor for Gpa2p |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
CDC14 |
YFR028C |
Protein phosphatase required for mitotic exit |
genetic |
1 |
1 |
1 |
Negative Genetic |
CTF18 |
YMR078C |
Subunit of a complex with Ctf8p |
genetic |
1 |
1 |
1 |
Positive Genetic |
DOA1 |
YKL213C |
WD-repeat protein involved in ubiquitin-mediated protein degradation |
genetic |
1 |
1 |
1 |
Negative Genetic |
EMG1 |
YLR186W |
Methyltransferase for rRNA |
genetic |
1 |
1 |
1 |
Negative Genetic |
FIP1 |
YJR093C |
Subunit of cleavage polyadenylation factor (CPF) |
genetic |
1 |
1 |
1 |
Negative Genetic |
DHH1 |
YDL160C |
Cytoplasmic DEAD-box helicase and mRNA decapping activator |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
DPB4 |
YDR121W |
Subunit of DNA pol epsilon and of ISW2 chromatin accessibility complex |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
ISW1 |
YBR245C |
ATPase subunit of imitation-switch (ISWI) class chromatin remodelers |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
END3 |
YNL084C |
EH domain-containing protein involved in endocytosis |
genetic |
1 |
1 |
1 |
Negative Genetic |
LSM2 |
YBL026W |
Lsm (Like Sm) protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
LSM7 |
YNL147W |
Lsm (Like Sm) protein |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
LST8 |
YNL006W |
Protein required for the transport of Gap1p |
genetic |
1 |
1 |
1 |
Negative Genetic |
MCM6 |
YGL201C |
Protein involved in DNA replication |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
LCD1 |
YDR499W |
Essential protein required for the DNA integrity checkpoint pathways |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
ARP8 |
YOR141C |
Nuclear actin-related protein involved in chromatin remodeling |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
HMO1 |
YDR174W |
Chromatin associated high mobility group (HMG) family member |
genetic |
1 |
1 |
1 |
Negative Genetic |
DOA4 |
YDR069C |
Ubiquitin hydrolase |
genetic |
1 |
1 |
1 |
Negative Genetic |
INO4 |
YOL108C |
Transcription factor involved in phospholipid synthesis |
genetic |
1 |
1 |
1 |
Positive Genetic |
MET18 |
YIL128W |
Component of cytosolic iron-sulfur protein assembly (CIA) machinery |
genetic |
1 |
1 |
1 |
Negative Genetic |
ILV1 |
YER086W |
Threonine deaminase, catalyzes first step in isoleucine biosynthesis |
genetic |
1 |
1 |
1 |
Negative Genetic |
GPT2 |
YKR067W |
Glycerol-3-phosphate/dihydroxyacetone phosphate sn-1 acyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
CDC6 |
YJL194W |
Essential ATP-binding protein required for DNA replication |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
ACE2 |
YLR131C |
Transcription factor required for septum destruction after cytokinesis |
genetic |
1 |
1 |
1 |
Negative Genetic |
CDC13 |
YDL220C |
Single stranded DNA-binding protein found at TG1-3 telomere G-tails |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
FIN1 |
YDR130C |
Spindle pole body-related intermediate filament protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
HYP2 |
YEL034W |
Translation elongation factor eIF-5A |
genetic |
1 |
1 |
1 |
Negative Genetic |
CAF20 |
YOR276W |
Phosphoprotein of the mRNA cap-binding complex |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
BUB2 |
YMR055C |
Mitotic exit network regulator |
genetic |
1 |
1 |
1 |
Negative Genetic |
GET1 |
YGL020C |
Subunit of the GET complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
BFA1 |
YJR053W |
Subunit of a two-component GTPase-activating protein, Bfa1p-Bub2p |
genetic |
1 |
1 |
1 |
Negative Genetic |
CDC9 |
YDL164C |
DNA ligase I found in nucleus and mitochondria |
genetic |
1 |
1 |
1 |
Negative Genetic |
ELM1 |
YKL048C |
Serine/threonine protein kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
EST1 |
YLR233C |
TLC1 RNA-associated factor involved in telomere length regulation |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
AIM46 |
YHR199C |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
CDC15 |
YAR019C |
Hippo-like kinase of the Mitotic Exit Network |
genetic |
1 |
1 |
1 |
Positive Genetic |
KRI1 |
YNL308C |
Essential nucleolar protein required for 40S ribosome biogenesis |
genetic |
1 |
1 |
1 |
Negative Genetic |
ISU1 |
YPL135W |
Conserved protein of the mitochondrial matrix |
genetic |
1 |
1 |
1 |
Negative Genetic |
CTF4 |
YPR135W |
Chromatin-associated protein |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
CTF4 |
YPR135W |
Chromatin-associated protein |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
CAF4 |
YKR036C |
WD40 repeat-containing protein associated with the CCR4-NOT complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
MIH1 |
YMR036C |
Protein tyrosine phosphatase |
genetic |
1 |
1 |
1 |
Negative Genetic |
CLB2 |
YPR119W |
B-type cyclin involved in cell cycle progression |
genetic |
1 |
1 |
1 |
Negative Genetic |
FAL1 |
YDR021W |
Nucleolar protein required for maturation of 18S rRNA |
genetic |
1 |
1 |
1 |
Negative Genetic |
BUB3 |
YOR026W |
Kinetochore checkpoint WD40 repeat protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
FCF1 |
YDR339C |
PINc domain endonuclease |
genetic |
1 |
1 |
1 |
Negative Genetic |
EXO70 |
YJL085W |
Subunit of the exocyst complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
BIR1 |
YJR089W |
Subunit of chromosomal passenger complex (CPC) |
genetic |
1 |
1 |
1 |
Negative Genetic |
CRC1 |
YOR100C |
Mitochondrial inner membrane carnitine transporter |
genetic |
1 |
1 |
1 |
Negative Genetic |
CSM2 |
YIL132C |
Subunit of the Shu complex (aka PCSS complex) |
genetic |
1 |
1 |
1 |
Negative Genetic |
CSM1 |
YCR086W |
Nucleolar protein that mediates homolog segregation during meiosis I |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
BIM1 |
YER016W |
Microtubule plus end-tracking protein |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
CSM3 |
YMR048W |
Replication fork associated factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
CDC34 |
YDR054C |
Ubiquitin-conjugating enzyme (E2) |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
CTF8 |
YHR191C |
Subunit of a complex with Ctf18p |
genetic |
1 |
1 |
1 |
Positive Genetic |
EXO1 |
YOR033C |
5'-3' exonuclease and flap-endonuclease |
genetic |
1 |
1 |
1 |
Negative Genetic |
CSG2 |
YBR036C |
Endoplasmic reticulum membrane protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
LRS4 |
YDR439W |
Nucleolar protein that forms a complex with Csm1p |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
SRS2 |
YJL092W |
DNA helicase and DNA-dependent ATPase |
physical |
1 |
1 |
1 |
Two-hybrid |
YAR010C |
YAR010C |
Retrotransposon TYA Gag gene co-transcribed with TYB Pol |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
TDH2 |
YJR009C |
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), isozyme 2 |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
POR1 |
YNL055C |
Mitochondrial porin (voltage-dependent anion channel) |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RIO2 |
YNL207W |
Essential serine kinase involved in the processing of 20S pre-rRNA |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
YVH1 |
YIR026C |
Dual specificity protein phosphatase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RTF1 |
YGL244W |
Subunit of RNAPII-associated chromatin remodeling Paf1 complex |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
PAF1 |
YBR279W |
Component of the Paf1p complex involved in transcription elongation |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
VAM6 |
YDL077C |
Guanine nucleotide exchange factor for the GTPase Gtr1p |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
PUF3 |
YLL013C |
Protein of the mitochondrial outer surface |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
SMC6 |
YLR383W |
Subunit of the SMC5-SMC6 complex |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RPS0A |
YGR214W |
Ribosomal 40S subunit protein S0A |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RPS2 |
YGL123W |
Protein component of the small (40S) subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RPS8A |
YBL072C |
Protein component of the small (40S) ribosomal subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RPS10A |
YOR293W |
Protein component of the small (40S) ribosomal subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RPS12 |
YOR369C |
Protein component of the small (40S) ribosomal subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RPS15 |
YOL040C |
Protein component of the small (40S) ribosomal subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RPS18A |
YDR450W |
Protein component of the small (40S) ribosomal subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RPS19A |
YOL121C |
Protein component of the small (40S) ribosomal subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RPS20 |
YHL015W |
Protein component of the small (40S) ribosomal subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RPS22A |
YJL190C |
Protein component of the small (40S) ribosomal subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RPL25 |
YOL127W |
Ribosomal 60S subunit protein L25 |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RPL26A |
YLR344W |
Ribosomal 60S subunit protein L26A |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RPS27A |
YKL156W |
Protein component of the small (40S) ribosomal subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RPL31A |
YDL075W |
Ribosomal 60S subunit protein L31A |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RPS3 |
YNL178W |
Protein component of the small (40S) ribosomal subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RPS14A |
YCR031C |
Protein component of the small (40S) ribosomal subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
MTQ2 |
YDR140W |
S-adenosylmethionine-dependent methyltransferase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
ORC6 |
YHR118C |
Subunit of the origin recognition complex (ORC) |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
RAD4 |
YER162C |
Damaged-DNA binding subunit of Nuclear Excision Repair Factor 2 |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
SPT4 |
YGR063C |
Spt4p/5p (DSIF) transcription elongation factor complex subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
RTT105 |
YER104W |
Chaperone for Replication Protein A complex (RPA) |
genetic |
1 |
1 |
1 |
Negative Genetic |
MNN10 |
YDR245W |
Subunit of a Golgi mannosyltransferase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
THP1 |
YOL072W |
Nuclear pore-associated protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
SHP1 |
YBL058W |
UBX domain-containing substrate adaptor for Cdc48p |
genetic |
1 |
1 |
1 |
Negative Genetic |
RMI1 |
YPL024W |
Subunit of the RecQ (Sgs1p) - Topo III (Top3p) complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
RPC31 |
YNL151C |
RNA polymerase III subunit C31 |
genetic |
1 |
1 |
1 |
Negative Genetic |
NUP84 |
YDL116W |
Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) |
genetic |
1 |
1 |
1 |
Negative Genetic |
PSP1 |
YDR505C |
Asn and gln rich protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
VPS21 |
YOR089C |
Endosomal Rab family GTPase |
genetic |
1 |
1 |
1 |
Negative Genetic |
UMP1 |
YBR173C |
Chaperone required for correct maturation of the 20S proteasome |
genetic |
1 |
1 |
1 |
Negative Genetic |
SCS7 |
YMR272C |
Sphingolipid alpha-hydroxylase |
genetic |
1 |
1 |
1 |
Negative Genetic |
SPN1 |
YPR133C |
Protein involved in RNA polymerase II transcription |
genetic |
1 |
1 |
1 |
Negative Genetic |
SWI4 |
YER111C |
DNA binding component of the SBF complex (Swi4p-Swi6p) |
genetic |
1 |
1 |
1 |
Negative Genetic |
SAP155 |
YFR040W |
Protein required for function of the Sit4p protein phosphatase |
genetic |
1 |
1 |
1 |
Negative Genetic |
UBR1 |
YGR184C |
E3 ubiquitin ligase (N-recognin) |
genetic |
1 |
1 |
1 |
Negative Genetic |
VPS8 |
YAL002W |
Membrane-binding component of the CORVET complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
SUS1 |
YBR111W-A |
Global transcriptional regulator, component of SAGA, TREX-2 complexes |
genetic |
1 |
1 |
1 |
Negative Genetic |
MSC1 |
YML128C |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Positive Genetic |
RAD24 |
YER173W |
Checkpoint protein |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
SEC14 |
YMR079W |
Phosphatidylinositol/phosphatidylcholine transfer protein |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
SPT16 |
YGL207W |
Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
PAT1 |
YCR077C |
Deadenylation-dependent mRNA-decapping factor |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
SWI6 |
YLR182W |
Transcription cofactor |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
NPT1 |
YOR209C |
Nicotinate phosphoribosyltransferase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
RAD53 |
YPL153C |
DNA damage response kinase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
VMA21 |
YGR105W |
Integral membrane protein required for V-ATPase function |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
VOA1 |
YGR106C |
ER protein that functions in assembly of the V0 sector of V-ATPase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
PTC1 |
YDL006W |
Type 2C protein phosphatase (PP2C) |
genetic |
1 |
1 |
1 |
Positive Genetic |
SWC5 |
YBR231C |
Component of the SWR1 complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
NPL3 |
YDR432W |
RNA-binding protein |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
STU1 |
YBL034C |
Microtubule plus-end-tracking non-motor protein |
genetic |
1 |
1 |
1 |
Positive Genetic |
POL12 |
YBL035C |
B subunit of DNA polymerase alpha-primase complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
POL2 |
YNL262W |
Catalytic subunit of DNA polymerase (II) epsilon |
genetic |
1 |
1 |
1 |
Positive Genetic |
RFA2 |
YNL312W |
Subunit of heterotrimeric Replication Protein A (RPA) |
genetic |
1 |
1 |
1 |
Positive Genetic |
RPG1 |
YBR079C |
eIF3a subunit of the eukaryotic translation initiation factor 3 (eIF3) |
genetic |
1 |
1 |
1 |
Negative Genetic |
TAF5 |
YBR198C |
Subunit (90 kDa) of TFIID and SAGA complexes |
genetic |
1 |
1 |
1 |
Negative Genetic |
NTF2 |
YER009W |
Nuclear envelope protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
TUB2 |
YFL037W |
Beta-tubulin |
genetic |
1 |
1 |
1 |
Negative Genetic |
RFA3 |
YJL173C |
Subunit of heterotrimeric Replication Protein A (RPA) |
genetic |
1 |
1 |
1 |
Negative Genetic |
RPL10 |
YLR075W |
Ribosomal 60S subunit protein L10 |
genetic |
1 |
1 |
1 |
Negative Genetic |
PDS5 |
YMR076C |
Cohesion maintenance factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
PBR1 |
YNL181W |
Putative oxidoreductase |
genetic |
1 |
1 |
1 |
Negative Genetic |
RAP1 |
YNL216W |
Essential DNA-binding transcription regulator that binds many loci |
genetic |
1 |
1 |
1 |
Negative Genetic |
SEC12 |
YNR026C |
Guanine nucleotide exchange factor (GEF) |
genetic |
1 |
1 |
1 |
Negative Genetic |
SMC5 |
YOL034W |
Subunit of the SMC5-SMC6 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
RFC1 |
YOR217W |
Subunit of heteropentameric Replication factor C (RF-C) |
genetic |
1 |
1 |
1 |
Negative Genetic |
RPT4 |
YOR259C |
ATPase of the 19S regulatory particle of the 26S proteasome |
genetic |
1 |
1 |
1 |
Negative Genetic |
RPN8 |
YOR261C |
Essential non-ATPase regulatory subunit of the 26S proteasome |
genetic |
1 |
1 |
1 |
Negative Genetic |
SEC16 |
YPL085W |
COPII vesicle coat protein required for ER transport vesicle budding |
genetic |
1 |
1 |
1 |
Negative Genetic |
UTP5 |
YDR398W |
Subunit of U3-containing Small Subunit (SSU) processome complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
SNM1 |
YDR478W |
Ribonuclease MRP complex subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
PRE4 |
YFR050C |
Beta 7 subunit of the 20S proteasome |
genetic |
1 |
1 |
1 |
Negative Genetic |
RPN12 |
YFR052W |
Subunit of the 19S regulatory particle of the 26S proteasome lid |
genetic |
1 |
1 |
1 |
Negative Genetic |
NBP35 |
YGL091C |
Essential cytoplasmic iron-sulfur cluster binding protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
PRP43 |
YGL120C |
RNA helicase in the DEAH-box family |
genetic |
1 |
1 |
1 |
Negative Genetic |
NUP192 |
YJL039C |
Essential subunit of inner ring of nuclear pore complex (NPC) |
genetic |
1 |
1 |
1 |
Negative Genetic |
RFC2 |
YJR068W |
Subunit of heteropentameric Replication factor C (RF-C) |
genetic |
1 |
1 |
1 |
Negative Genetic |
NOP2 |
YNL061W |
rRNA m5C methyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
NOG2 |
YNR053C |
Putative GTPase |
genetic |
1 |
1 |
1 |
Negative Genetic |
ULP1 |
YPL020C |
Protease that specifically cleaves Smt3p protein conjugates |
genetic |
1 |
1 |
1 |
Negative Genetic |
NAB3 |
YPL190C |
RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p) |
genetic |
1 |
1 |
1 |
Negative Genetic |
NUP60 |
YAR002W |
FG-nucleoporin component of central core of the nuclear pore complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
SFT2 |
YBL102W |
Tetra-spanning membrane protein found mostly in the late Golgi |
genetic |
1 |
1 |
1 |
Negative Genetic |
YGR153W |
YGR153W |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
SMI1 |
YGR229C |
Protein involved in the regulation of cell wall synthesis |
genetic |
1 |
1 |
1 |
Negative Genetic |
YLL054C |
YLL054C |
Putative protein of unknown function with similarity to Pip2p |
genetic |
1 |
1 |
1 |
Negative Genetic |
SSK1 |
YLR006C |
Cytoplasmic phosphorelay intermediate osmosensor and regulator |
genetic |
1 |
1 |
1 |
Negative Genetic |
PSP2 |
YML017W |
Asn rich cytoplasmic protein that contains RGG motifs |
genetic |
1 |
1 |
1 |
Negative Genetic |
NAT4 |
YMR069W |
N alpha-acetyl-transferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
YMR230W-A |
YMR230W-A |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
YKU80 |
YMR106C |
Subunit of telomeric Ku complex (Yku70p-Yku80p) |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
YNR068C |
YNR068C |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
TGS1 |
YPL157W |
Trimethyl guanosine synthase, conserved nucleolar methyl transferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
RPL8B |
YLL045C |
Ribosomal 60S subunit protein L8A |
genetic |
1 |
1 |
1 |
Negative Genetic |
TOP3 |
YLR234W |
DNA Topoisomerase III |
genetic |
1 |
1 |
1 |
Negative Genetic |
URA10 |
YMR271C |
Minor orotate phosphoribosyltransferase (OPRTase) isozyme |
genetic |
1 |
1 |
1 |
Negative Genetic |
YNG2 |
YHR090C |
Subunit of NuA4, an essential histone acetyltransferase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
PHS1 |
YJL097W |
Essential 3-hydroxyacyl-CoA dehydratase of the ER membrane |
genetic |
1 |
1 |
1 |
Positive Genetic |
MOG1 |
YJR074W |
Conserved nuclear protein that interacts with GTP-Gsp1p |
genetic |
1 |
1 |
1 |
Negative Genetic |
RTT109 |
YLL002W |
Histone acetyltransferase |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
RTT106 |
YNL206C |
Histone chaperone |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
RAD5 |
YLR032W |
DNA helicase/Ubiquitin ligase |
genetic |
1 |
1 |
1 |
Negative Genetic |
PSY3 |
YLR376C |
Component of Shu complex (aka PCSS complex) |
genetic |
1 |
1 |
1 |
Negative Genetic |
RAD61 |
YDR014W |
Subunit of a complex that inhibits sister chromatid cohesion |
genetic |
1 |
1 |
1 |
Negative Genetic |
SHU1 |
YHL006C |
Component of Shu complex (aka PCSS complex) |
genetic |
1 |
1 |
1 |
Negative Genetic |
POF1 |
YCL047C |
Nicotinamide mononucleotide-specific adenylyltransferase (NMNAT) |
genetic |
1 |
1 |
1 |
Negative Genetic |
TUB4 |
YLR212C |
Gamma-tubulin |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
SIR2 |
YDL042C |
Conserved NAD+ dependent histone deacetylase of the Sirtuin family |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
KCS1 |
YDR017C |
Inositol hexakisphosphate and inositol heptakisphosphate kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
HST4 |
YDR191W |
NAD(+)-dependent protein deacetylase |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
LIP1 |
YMR298W |
Ceramide synthase subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
MDM34 |
YGL219C |
Mitochondrial component of the ERMES complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
LDB18 |
YLL049W |
Component of the dynactin complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
MAL33 |
YBR297W |
MAL-activator protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
HMS2 |
YJR147W |
Protein with similarity to heat shock transcription factors |
genetic |
1 |
1 |
1 |
Negative Genetic |