| CDH1 |
YGL003C |
Activator of anaphase-promoting complex/cyclosome (APC/C) |
physical |
19 |
6 |
13 |
Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Two-hybrid, Protein-peptide, Reconstituted Complex, Biochemical Activity, Affinity Capture-Western, Reconstituted Complex, Two-hybrid, Two-hybrid, Affinity Capture-Western, Biochemical Activity, Affinity Capture-MS, Two-hybrid, Biochemical Activity, Biochemical Activity, Biochemical Activity |
| MIH1 |
YMR036C |
Protein tyrosine phosphatase |
genetic |
16 |
4 |
11 |
Negative Genetic, Negative Genetic, Synthetic Rescue, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Rescue, Negative Genetic, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Lethality, Dosage Growth Defect, Negative Genetic, Negative Genetic |
| CLB2 |
YPR119W |
B-type cyclin involved in cell cycle progression |
genetic |
10 |
2 |
8 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Phenotypic Enhancement, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| HSL7 |
YBR133C |
Protein arginine N-methyltransferase |
physical |
10 |
5 |
3 |
Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Two-hybrid, Two-hybrid, Biochemical Activity, Co-localization, Affinity Capture-Western, Biochemical Activity |
| CTF18 |
YMR078C |
Subunit of a complex with Ctf8p |
genetic |
9 |
2 |
7 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| DCC1 |
YCL016C |
Subunit of a complex with Ctf8p and Ctf18p |
genetic |
9 |
2 |
7 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| CTF8 |
YHR191C |
Subunit of a complex with Ctf18p |
genetic |
9 |
1 |
7 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| NBP2 |
YDR162C |
Protein involved in the HOG (high osmolarity glycerol) pathway |
genetic |
9 |
1 |
6 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| CTF4 |
YPR135W |
Chromatin-associated protein |
genetic |
8 |
2 |
7 |
Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| ZDS1 |
YMR273C |
Protein with a role in regulating Swe1p-dependent polarized growth |
genetic |
8 |
2 |
6 |
Dosage Rescue, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| FKH2 |
YNL068C |
Forkhead family transcription factor |
genetic |
8 |
2 |
5 |
Negative Genetic, Negative Genetic, Negative Genetic, Dosage Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| CLA4 |
YNL298W |
Cdc42p-activated signal transducing kinase |
genetic |
7 |
2 |
7 |
Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| MBP1 |
YDL056W |
Transcription factor |
genetic |
7 |
1 |
6 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| CDC23 |
YHR166C |
Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) |
genetic |
7 |
2 |
5 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| CDC7 |
YDL017W |
S/T kinase and catalytic subunit of DDK (Dbf4-dependent kinase) |
genetic |
7 |
2 |
5 |
Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| POL32 |
YJR043C |
Third subunit of DNA polymerase delta |
genetic |
7 |
1 |
5 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| MMS1 |
YPR164W |
Subunit of E3 ubiquitin ligase complex involved in replication repair |
genetic |
7 |
1 |
5 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| GAS1 |
YMR307W |
Beta-1,3-glucanosyltransferase required for cell wall assembly |
genetic |
7 |
1 |
5 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| CDC20 |
YGL116W |
Activator of anaphase-promoting complex/cyclosome (APC/C) |
physical |
7 |
3 |
4 |
Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Two-hybrid, Affinity Capture-Western, Reconstituted Complex, Two-hybrid |
| CDC28 |
YBR160W |
Cyclin-dependent kinase (CDK) catalytic subunit |
genetic |
6 |
3 |
5 |
Synthetic Lethality, Phenotypic Enhancement, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| CKS1 |
YBR135W |
Cyclin-dependent protein kinase regulatory subunit and adaptor |
genetic |
6 |
2 |
5 |
Negative Genetic, Negative Genetic, Dosage Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic |
| RTT109 |
YLL002W |
Histone acetyltransferase |
genetic |
6 |
1 |
5 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| UBC4 |
YBR082C |
Ubiquitin-conjugating enzyme (E2) |
genetic |
6 |
1 |
5 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| RAD5 |
YLR032W |
DNA helicase/Ubiquitin ligase |
genetic |
6 |
1 |
5 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| SRB2 |
YHR041C |
Subunit of the RNA polymerase II mediator complex |
genetic |
6 |
1 |
4 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| SDS3 |
YIL084C |
Component of the Rpd3L histone deacetylase complex |
genetic |
6 |
1 |
4 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| MMS22 |
YLR320W |
Subunit of E3 ubiquitin ligase complex involved in replication repair |
genetic |
6 |
1 |
4 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| DEP1 |
YAL013W |
Component of the Rpd3L histone deacetylase complex |
genetic |
6 |
1 |
4 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| ELM1 |
YKL048C |
Serine/threonine protein kinase |
genetic |
5 |
3 |
5 |
Synthetic Rescue, Synthetic Rescue, Synthetic Lethality, Synthetic Rescue, Phenotypic Suppression |
| SWE1 |
YJL187C |
Protein kinase that regulates the G2/M transition |
genetic |
5 |
2 |
5 |
Synthetic Rescue, Synthetic Rescue, Phenotypic Suppression, Synthetic Rescue, Synthetic Rescue |
| SEC22 |
YLR268W |
R-SNARE protein |
genetic |
5 |
1 |
5 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| LTE1 |
YAL024C |
Protein similar to GDP/GTP exchange factors |
genetic |
5 |
2 |
4 |
Negative Genetic, Phenotypic Enhancement, Negative Genetic, Negative Genetic, Negative Genetic |
| CDC11 |
YJR076C |
Component of the septin ring that is required for cytokinesis |
genetic |
5 |
1 |
4 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| UME6 |
YDR207C |
Rpd3L histone deacetylase complex subunit |
genetic |
5 |
1 |
4 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| MSN5 |
YDR335W |
Karyopherin |
genetic |
5 |
1 |
4 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| SIN3 |
YOL004W |
Component of both the Rpd3S and Rpd3L histone deacetylase complexes |
genetic |
5 |
1 |
4 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| HST3 |
YOR025W |
Sirtuin, histone H3 deacetylase |
genetic |
5 |
1 |
4 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| LST8 |
YNL006W |
Protein required for the transport of Gap1p |
genetic |
5 |
1 |
4 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| APC5 |
YOR249C |
Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) |
genetic |
5 |
1 |
4 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| CDC27 |
YBL084C |
Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) |
genetic |
5 |
1 |
4 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| GAB1 |
YLR459W |
Subunit of the glycosylphosphatidylinositol transamidase complex |
genetic |
5 |
1 |
4 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| RNT1 |
YMR239C |
Nuclear dsRNA-specific ribonuclease (RNase III) |
genetic |
5 |
3 |
3 |
Phenotypic Suppression, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic |
| PTC1 |
YDL006W |
Type 2C protein phosphatase (PP2C) |
genetic |
5 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| SMI1 |
YGR229C |
Protein involved in the regulation of cell wall synthesis |
genetic |
5 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| GIN4 |
YDR507C |
Protein kinase involved in bud growth and assembly of the septin ring |
genetic |
4 |
3 |
4 |
Phenotypic Enhancement, Synthetic Lethality, Phenotypic Suppression, Phenotypic Enhancement |
| RTG3 |
YBL103C |
bHLH/Zip transcription factor for retrograde (RTG) and TOR pathways |
genetic |
4 |
2 |
4 |
Positive Genetic, Positive Genetic, Negative Genetic, Positive Genetic |
| PKC1 |
YBL105C |
Protein serine/threonine kinase |
genetic |
4 |
2 |
4 |
Negative Genetic, Negative Genetic, Positive Genetic, Positive Genetic |
| MNN10 |
YDR245W |
Subunit of a Golgi mannosyltransferase complex |
genetic |
4 |
1 |
4 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| PDS1 |
YDR113C |
Securin |
genetic |
4 |
1 |
4 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| CIN8 |
YEL061C |
Bipolar kinesin motor protein |
genetic |
4 |
1 |
4 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| BEM4 |
YPL161C |
Protein involved in establishment of cell polarity and bud emergence |
genetic |
4 |
1 |
4 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| DBF2 |
YGR092W |
Ser/Thr kinase involved in transcription and stress response |
genetic |
4 |
1 |
4 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| CLB3 |
YDL155W |
B-type cyclin involved in cell cycle progression |
genetic |
4 |
1 |
4 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| CDH1 |
YGL003C |
Activator of anaphase-promoting complex/cyclosome (APC/C) |
genetic |
4 |
2 |
3 |
Negative Genetic, Dosage Growth Defect, Negative Genetic, Negative Genetic |
| GWT1 |
YJL091C |
Protein involved in the inositol acylation of GlcN-PI |
genetic |
4 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| CDC48 |
YDL126C |
AAA ATPase with protein-unfoldase activity |
genetic |
4 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| CEG1 |
YGL130W |
Guanylyltransferase involved in mRNA 5' capping |
genetic |
4 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| VPS8 |
YAL002W |
Membrane-binding component of the CORVET complex |
genetic |
4 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| MED8 |
YBR193C |
Subunit of the RNA polymerase II mediator complex |
genetic |
4 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| SWM1 |
YDR260C |
Subunit of the anaphase-promoting complex (APC) |
genetic |
4 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| CDC20 |
YGL116W |
Activator of anaphase-promoting complex/cyclosome (APC/C) |
genetic |
4 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| CDC37 |
YDR168W |
Essential Hsp90p co-chaperone |
genetic |
4 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| GPI8 |
YDR331W |
Catalytic subunit of the ER membrane GPI transamidase complex |
genetic |
4 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| NAP1 |
YKR048C |
Histone chaperone and assembly chaperone for Rps6a/b |
physical |
3 |
3 |
3 |
Biochemical Activity, Affinity Capture-MS, PCA |
| CDC55 |
YGL190C |
Regulatory subunit B of protein phosphatase 2A (PP2A) |
genetic |
3 |
2 |
3 |
Negative Genetic, Dosage Growth Defect, Negative Genetic |
| RAP1 |
YNL216W |
Essential DNA-binding transcription regulator that binds many loci |
genetic |
3 |
2 |
3 |
Positive Genetic, Positive Genetic, Negative Genetic |
| CLN2 |
YPL256C |
G1 cyclin involved in regulation of the cell cycle |
genetic |
3 |
2 |
3 |
Negative Genetic, Dosage Growth Defect, Negative Genetic |
| ABD1 |
YBR236C |
Methyltransferase |
genetic |
3 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic |
| BUD14 |
YAR014C |
Protein involved in bud-site selection |
genetic |
3 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic |
| SWI4 |
YER111C |
DNA binding component of the SBF complex (Swi4p-Swi6p) |
genetic |
3 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic |
| SEC66 |
YBR171W |
Non-essential subunit of Sec63 complex |
genetic |
3 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic |
| RPN10 |
YHR200W |
Proteasome polyubiquitin receptor |
genetic |
3 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic |
| SIC1 |
YLR079W |
Cyclin-dependent kinase inhibitor (CKI) |
genetic |
3 |
1 |
3 |
Positive Genetic, Positive Genetic, Positive Genetic |
| PEF1 |
YGR058W |
Penta-EF-hand protein |
genetic |
3 |
1 |
3 |
Positive Genetic, Positive Genetic, Positive Genetic |
| PIR5 |
YJL160C |
Putative protein of unknown function |
genetic |
3 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic |
| NRM1 |
YNR009W |
Transcriptional co-repressor of MBF-regulated gene expression |
genetic |
3 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic |
| RAD52 |
YML032C |
Protein involved in homologous recombination |
genetic |
3 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic |
| GET2 |
YER083C |
Subunit of the GET complex |
genetic |
3 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic |
| CAK1 |
YFL029C |
Cyclin-dependent kinase-activating kinase |
genetic |
3 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic |
| GUP1 |
YGL084C |
Plasma membrane protein involved in remodeling GPI anchors |
genetic |
3 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic |
| HSL1 |
YKL101W |
Nim1p-related protein kinase |
physical |
3 |
3 |
2 |
Affinity Capture-Western, Two-hybrid, PCA |
| ARL1 |
YBR164C |
Soluble GTPase with a role in regulation of membrane traffic |
genetic |
3 |
1 |
2 |
Positive Genetic, Positive Genetic, Positive Genetic |
| SUM1 |
YDR310C |
Transcriptional repressor that regulates middle-sporulation genes |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| ECM33 |
YBR078W |
GPI-anchored protein involved in efficient glucose uptake |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| GPI16 |
YHR188C |
Subunit of the glycosylphosphatidylinositol transamidase complex |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| DBF4 |
YDR052C |
Regulatory subunit of Cdc7p-Dbf4p kinase complex |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| DPM1 |
YPR183W |
Dolichol phosphate mannose (Dol-P-Man) synthase of ER membrane |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| FKH1 |
YIL131C |
Forkhead family transcription factor |
regulation |
2 |
2 |
2 |
chromatin immunoprecipitation-chip evidence, ChEC-Seq experiments |
| FKH2 |
YNL068C |
Forkhead family transcription factor |
regulation |
2 |
2 |
2 |
chromatin immunoprecipitation-chip evidence, ChEC-Seq experiments |
| CDC11 |
YJR076C |
Component of the septin ring that is required for cytokinesis |
physical |
2 |
2 |
2 |
Two-hybrid, Reconstituted Complex |
| CDC12 |
YHR107C |
Component of the septin ring that is required for cytokinesis |
physical |
2 |
2 |
2 |
Two-hybrid, Affinity Capture-Western |
| DYN1 |
YKR054C |
Cytoplasmic heavy chain dynein |
genetic |
2 |
2 |
2 |
Phenotypic Suppression, Positive Genetic |
| KCC4 |
YCL024W |
Protein kinase of the bud neck involved in the septin checkpoint |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Phenotypic Enhancement |
| SET1 |
YHR119W |
Histone methyltransferase, subunit of the COMPASS (Set1C) complex |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Negative Genetic |
| TPK1 |
YJL164C |
cAMP-dependent protein kinase catalytic subunit |
genetic |
2 |
2 |
2 |
Positive Genetic, Negative Genetic |
| WHI5 |
YOR083W |
Repressor of G1 transcription |
genetic |
2 |
2 |
2 |
Positive Genetic, Dosage Growth Defect |
| RAD50 |
YNL250W |
Subunit of MRX complex with Mre11p and Xrs2p |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Negative Genetic |
| KEL1 |
YHR158C |
Protein required for proper cell fusion and cell morphology |
genetic |
2 |
2 |
2 |
Dosage Growth Defect, Negative Genetic |
| GIN4 |
YDR507C |
Protein kinase involved in bud growth and assembly of the septin ring |
physical |
2 |
2 |
2 |
Affinity Capture-MS, PCA |
| BEM3 |
YPL115C |
Rho GTPase activating protein (RhoGAP) |
genetic |
2 |
2 |
2 |
Dosage Growth Defect, Negative Genetic |
| HSL1 |
YKL101W |
Nim1p-related protein kinase |
regulation |
2 |
1 |
2 |
protein kinase assay evidence, protein kinase assay evidence |
| HSL7 |
YBR133C |
Protein arginine N-methyltransferase |
regulation |
2 |
1 |
2 |
protein kinase assay evidence, protein kinase assay evidence |
| ACT1 |
YFL039C |
Actin, structural protein in cytoskeleton |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| KRE33 |
YNL132W |
Acetyltransferase required for biogenesis of small ribosomal subunit |
physical |
2 |
1 |
2 |
Affinity Capture-MS, Affinity Capture-MS |
| SLX5 |
YDL013W |
Subunit of the Slx5-Slx8 SUMO-targeted Ub ligase (STUbL) complex |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| PUF3 |
YLL013C |
Protein of the mitochondrial outer surface |
physical |
2 |
1 |
2 |
Affinity Capture-RNA, Affinity Capture-RNA |
| SLA1 |
YBL007C |
Cytoskeletal protein binding protein |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| TSA1 |
YML028W |
Thioredoxin peroxidase |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| SWP1 |
YMR149W |
Delta subunit of the oligosaccharyl transferase glycoprotein complex |
genetic |
2 |
1 |
2 |
Positive Genetic, Positive Genetic |
| RTT101 |
YJL047C |
Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| RXT2 |
YBR095C |
Component of the histone deacetylase Rpd3L complex |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| ILM1 |
YJR118C |
Protein of unknown function |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| RUD3 |
YOR216C |
Golgi matrix protein |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| NUM1 |
YDR150W |
Protein required for nuclear migration |
genetic |
2 |
1 |
2 |
Positive Genetic, Positive Genetic |
| MCM5 |
YLR274W |
Component of the Mcm2-7 hexameric helicase complex |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| MED7 |
YOL135C |
Subunit of the RNA polymerase II mediator complex |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| RNA1 |
YMR235C |
GTPase activating protein (GAP) for Gsp1p |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| MED4 |
YOR174W |
Subunit of the RNA polymerase II mediator complex |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| SGF73 |
YGL066W |
Subunit of DUBm module of SAGA and SLIK |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| SAP30 |
YMR263W |
Component of Rpd3L histone deacetylase complex |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| RAD51 |
YER095W |
Strand exchange protein |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| DMA2 |
YNL116W |
Ubiquitin-protein ligase (E3) |
genetic |
2 |
1 |
2 |
Synthetic Lethality, Synthetic Lethality |
| DMA1 |
YHR115C |
Ubiquitin-protein ligase (E3) |
genetic |
2 |
1 |
2 |
Synthetic Lethality, Synthetic Lethality |
| APC11 |
YDL008W |
Catalytic core subunit, Anaphase-Promoting Complex/Cyclosome (APC/C) |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| CHL1 |
YPL008W |
Probable DNA helicase |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| BRN1 |
YBL097W |
Subunit of the condensin complex |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| GIM4 |
YEL003W |
Subunit of the heterohexameric cochaperone prefoldin complex |
genetic |
2 |
1 |
2 |
Positive Genetic, Positive Genetic |
| GPI2 |
YPL076W |
Protein involved in the synthesis of GlcNAc-PI |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| ASE1 |
YOR058C |
Mitotic spindle midzone-localized microtubule bundling protein |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| BST1 |
YFL025C |
GPI inositol deacylase of the endoplasmic reticulum (ER) |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| ARV1 |
YLR242C |
Cortical ER protein |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| GPI19 |
YDR437W |
Subunit of GPI-GlcNAc transferase involved in synthesis of GlcNAc-PI |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| FMC1 |
YIL098C |
Mitochondrial matrix protein |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| CDC1 |
YDR182W |
Putative mannose-ethanolamine phosphate phosphodiesterase |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| OST3 |
YOR085W |
Gamma subunit of the oligosaccharyltransferase complex of the ER lumen |
genetic |
2 |
2 |
1 |
Positive Genetic, Negative Genetic |
| HOG1 |
YLR113W |
Mitogen-activated protein kinase involved in osmoregulation |
physical |
2 |
2 |
1 |
Affinity Capture-Western, Biochemical Activity |
| CDC14 |
YFR028C |
Protein phosphatase required for mitotic exit |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| CDC3 |
YLR314C |
Component of the septin ring that is required for cytokinesis |
physical |
2 |
1 |
1 |
Affinity Capture-Western, Affinity Capture-Western |
| RPN6 |
YDL097C |
Essential, non-ATPase regulatory subunit of the 26S proteasome lid |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| POL3 |
YDL102W |
Catalytic subunit of DNA polymerase delta |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| SLU7 |
YDR088C |
RNA splicing factor |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| MOB2 |
YFL034C-B |
Activator of Cbk1p kinase |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| RPN12 |
YFR052W |
Subunit of the 19S regulatory particle of the 26S proteasome lid |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| MED6 |
YHR058C |
Subunit of the RNA polymerase II mediator complex |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| MED11 |
YMR112C |
Subunit of the RNA polymerase II mediator complex |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| VTI1 |
YMR197C |
Protein involved in cis-Golgi membrane traffic |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| VPS29 |
YHR012W |
Subunit of the membrane-associated retromer complex |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| LDB18 |
YLL049W |
Component of the dynactin complex |
genetic |
2 |
1 |
1 |
Positive Genetic, Positive Genetic |
| MOT3 |
YMR070W |
Transcriptional repressor, activator |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| GPI17 |
YDR434W |
Transmembrane protein |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| GPI10 |
YGL142C |
Integral membrane protein involved in GPI anchor synthesis |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| AFT2 |
YPL202C |
Iron-regulated transcriptional activator |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| YAP6 |
YDR259C |
Basic leucine zipper (bZIP) transcription factor |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| CDC28 |
YBR160W |
Cyclin-dependent kinase (CDK) catalytic subunit |
regulation |
1 |
1 |
1 |
quantitative mass spectrometry evidence |
| SWI4 |
YER111C |
DNA binding component of the SBF complex (Swi4p-Swi6p) |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| GCN4 |
YEL009C |
bZIP transcriptional activator of amino acid biosynthetic genes |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| PHO2 |
YDL106C |
Homeobox transcription factor |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| CAD1 |
YDR423C |
AP-1-like basic leucine zipper (bZIP) transcriptional activator |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| AFT1 |
YGL071W |
Transcription factor involved in iron utilization and homeostasis |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| MBP1 |
YDL056W |
Transcription factor |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| SWE1 |
YJL187C |
Protein kinase that regulates the G2/M transition |
regulation |
1 |
1 |
1 |
protein kinase assay evidence |
| CTF19 |
YPL018W |
Outer kinetochore protein, needed for accurate chromosome segregation |
genetic |
1 |
1 |
1 |
Positive Genetic |
| DSN1 |
YIR010W |
Essential component of the outer kinetochore MIND complex |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
| CKB2 |
YOR039W |
Beta' regulatory subunit of casein kinase 2 (CK2) |
genetic |
1 |
1 |
1 |
Positive Genetic |
| BRX1 |
YOL077C |
Nucleolar protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DRS1 |
YLL008W |
Nucleolar DEAD-box protein required for ribosome assembly and function |
physical |
1 |
1 |
1 |
Biochemical Activity |
| BRE1 |
YDL074C |
E3 ubiquitin ligase |
physical |
1 |
1 |
1 |
Biochemical Activity |
| BRE1 |
YDL074C |
E3 ubiquitin ligase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ARC1 |
YGL105W |
Protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases |
physical |
1 |
1 |
1 |
Biochemical Activity |
| CDC33 |
YOL139C |
Translation initiation factor eIF4E |
physical |
1 |
1 |
1 |
Biochemical Activity |
| ALA1 |
YOR335C |
Cytoplasmic and mitochondrial alanyl-tRNA synthetase |
physical |
1 |
1 |
1 |
Biochemical Activity |
| CCR4 |
YAL021C |
Component of the CCR4-NOT transcriptional complex |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| HGH1 |
YGR187C |
Chaperone protein for translation factor eEF2 |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| APC1 |
YNL172W |
Largest subunit of the Anaphase-Promoting Complex/Cyclosome |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ARC15 |
YIL062C |
Subunit of the ARP2/3 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ARC35 |
YNR035C |
Subunit of the ARP2/3 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ARO1 |
YDR127W |
Pentafunctional arom protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ARP3 |
YJR065C |
Essential component of the Arp2/3 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ASF1 |
YJL115W |
Nucleosome assembly factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| BDF1 |
YLR399C |
BET family transcriptional regulator |
genetic |
1 |
1 |
1 |
Negative Genetic |
| BEM2 |
YER155C |
Rho GTPase activating protein (RhoGAP) |
genetic |
1 |
1 |
1 |
Positive Genetic |
| CDC14 |
YFR028C |
Protein phosphatase required for mitotic exit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| CDC24 |
YAL041W |
Guanine nucleotide exchange factor (GEF) for Cdc42p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CDC10 |
YCR002C |
Component of the septin ring, required for cytokinesis |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CDC36 |
YDL165W |
Component of the CCR4-NOT core complex, involved in mRNA decapping |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CNS1 |
YBR155W |
TPR-containing co-chaperone |
physical |
1 |
1 |
1 |
Biochemical Activity |
| ERO1 |
YML130C |
Thiol oxidase required for oxidative protein folding in the ER |
genetic |
1 |
1 |
1 |
Positive Genetic |
| GCN2 |
YDR283C |
Protein kinase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| GLO3 |
YER122C |
ADP-ribosylation factor GTPase activating protein (ARF GAP) |
physical |
1 |
1 |
1 |
Biochemical Activity |
| ESP1 |
YGR098C |
Separase/separin, a caspase-like cysteine protease |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| DHH1 |
YDL160C |
Cytoplasmic DEAD-box helicase and mRNA decapping activator |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| ARB1 |
YER036C |
ATPase of the ATP-binding cassette (ABC) family |
physical |
1 |
1 |
1 |
Biochemical Activity |
| MCK1 |
YNL307C |
Dual-specificity ser/thr and tyrosine protein kinase |
physical |
1 |
1 |
1 |
Biochemical Activity |
| MCK1 |
YNL307C |
Dual-specificity ser/thr and tyrosine protein kinase |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
| TPK2 |
YPL203W |
cAMP-dependent protein kinase catalytic subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| RTT102 |
YGR275W |
Component of both the SWI/SNF and RSC chromatin remodeling complexes |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| SPS19 |
YNL202W |
Peroxisomal 2,4-dienoyl-CoA reductase |
physical |
1 |
1 |
1 |
Biochemical Activity |
| SLX5 |
YDL013W |
Subunit of the Slx5-Slx8 SUMO-targeted Ub ligase (STUbL) complex |
physical |
1 |
1 |
1 |
Biochemical Activity |
| YJR096W |
YJR096W |
Xylose and arabinose reductase |
physical |
1 |
1 |
1 |
Biochemical Activity |
| SES1 |
YDR023W |
Cytosolic seryl-tRNA synthetase |
physical |
1 |
1 |
1 |
Biochemical Activity |
| LOT6 |
YLR011W |
FMN-dependent NAD(P)H:quinone reductase |
physical |
1 |
1 |
1 |
Biochemical Activity |
| SIS1 |
YNL007C |
Type II HSP40 co-chaperone that interacts with the HSP70 protein Ssa1p |
physical |
1 |
1 |
1 |
Biochemical Activity |
| NOT5 |
YPR072W |
Component of the CCR4-NOT core complex, involved in mRNA decapping |
physical |
1 |
1 |
1 |
Biochemical Activity |
| PAH1 |
YMR165C |
Mg2+-dependent phosphatidate (PA) phosphatase |
physical |
1 |
1 |
1 |
Biochemical Activity |
| UBX7 |
YBR273C |
UBX (ubiquitin regulatory X) domain-containing protein |
physical |
1 |
1 |
1 |
Biochemical Activity |
| VPS27 |
YNR006W |
Endosomal protein that forms a complex with Hse1p |
physical |
1 |
1 |
1 |
Biochemical Activity |
| MEP1 |
YGR121C |
Ammonium permease |
physical |
1 |
1 |
1 |
Biochemical Activity |
| SEC2 |
YNL272C |
Guanyl-nucleotide exchange factor for the small G-protein Sec4p |
physical |
1 |
1 |
1 |
Biochemical Activity |
| YDR034C-C |
YDR034C-C |
Retrotransposon TYA Gag gene co-transcribed with TYB Pol |
physical |
1 |
1 |
1 |
Biochemical Activity |
| NGL2 |
YMR285C |
Protein involved in 5.8S rRNA processing |
physical |
1 |
1 |
1 |
Biochemical Activity |
| SSA2 |
YLL024C |
HSP70 family ATP-binding protein |
physical |
1 |
1 |
1 |
Biochemical Activity |
| IPA1 |
YJR141W |
Protein implicated in pre-mRNA processing and proteasomal degradation |
physical |
1 |
1 |
1 |
Biochemical Activity |
| UTP5 |
YDR398W |
Subunit of U3-containing Small Subunit (SSU) processome complex |
physical |
1 |
1 |
1 |
Biochemical Activity |
| PRX1 |
YBL064C |
Mitochondrial peroxiredoxin with thioredoxin peroxidase activity |
physical |
1 |
1 |
1 |
Biochemical Activity |
| NCL1 |
YBL024W |
S-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase |
physical |
1 |
1 |
1 |
Biochemical Activity |
| RNT1 |
YMR239C |
Nuclear dsRNA-specific ribonuclease (RNase III) |
physical |
1 |
1 |
1 |
Biochemical Activity |
| SSE2 |
YBR169C |
Member of Hsp110 subclass of the heat shock protein 70 (HSP70) family |
physical |
1 |
1 |
1 |
Biochemical Activity |
| MGR3 |
YMR115W |
Subunit of the mitochondrial (mt) i-AAA protease supercomplex |
physical |
1 |
1 |
1 |
Biochemical Activity |
| TEF2 |
YBR118W |
Translational elongation factor EF-1 alpha |
physical |
1 |
1 |
1 |
Biochemical Activity |
| UBP9 |
YER098W |
Ubiquitin-specific protease that cleaves ubiquitin-protein fusions |
physical |
1 |
1 |
1 |
Biochemical Activity |
| YMR155W |
YMR155W |
Putative protein of unknown function |
physical |
1 |
1 |
1 |
Biochemical Activity |
| RBD2 |
YPL246C |
Possible rhomboid protease |
physical |
1 |
1 |
1 |
Biochemical Activity |
| TRM13 |
YOL125W |
2'-O-methyltransferase |
physical |
1 |
1 |
1 |
Biochemical Activity |
| YBR285W |
YBR285W |
Putative protein of unknown function |
physical |
1 |
1 |
1 |
Biochemical Activity |
| RRP5 |
YMR229C |
RNA binding protein involved in synthesis of 18S and 5.8S rRNAs |
physical |
1 |
1 |
1 |
Biochemical Activity |
| NOT3 |
YIL038C |
Component of the CCR4-NOT core complex, involved in mRNA decapping |
physical |
1 |
1 |
1 |
Biochemical Activity |
| NMT1 |
YLR195C |
N-myristoyl transferase |
physical |
1 |
1 |
1 |
Biochemical Activity |
| YGR210C |
YGR210C |
Putative protein of unknown function |
physical |
1 |
1 |
1 |
Biochemical Activity |
| SPT16 |
YGL207W |
Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) |
physical |
1 |
1 |
1 |
Biochemical Activity |
| YPR137C-A |
YPR137C-A |
Retrotransposon TYA Gag gene co-transcribed with TYB Pol |
physical |
1 |
1 |
1 |
Biochemical Activity |
| SHE3 |
YBR130C |
Protein adaptor between Myo4p and the She2p-mRNA complex |
physical |
1 |
1 |
1 |
Biochemical Activity |
| NHP10 |
YDL002C |
Non-essential INO80 chromatin remodeling complex subunit |
physical |
1 |
1 |
1 |
Biochemical Activity |
| YAP3 |
YHL009C |
Basic leucine zipper (bZIP) transcription factor |
physical |
1 |
1 |
1 |
Biochemical Activity |
| YPL257W-A |
YPL257W-A |
Retrotransposon TYA Gag gene co-transcribed with TYB Pol |
physical |
1 |
1 |
1 |
Biochemical Activity |
| TMA16 |
YOR252W |
Protein of unknown function that associates with ribosomes |
physical |
1 |
1 |
1 |
Biochemical Activity |
| YDJ1 |
YNL064C |
Type I HSP40 co-chaperone |
physical |
1 |
1 |
1 |
Biochemical Activity |
| YDJ1 |
YNL064C |
Type I HSP40 co-chaperone |
genetic |
1 |
1 |
1 |
Positive Genetic |
| THS1 |
YIL078W |
Threonyl-tRNA synthetase |
physical |
1 |
1 |
1 |
Biochemical Activity |
| RNH70 |
YGR276C |
3'-5' exoribonuclease |
physical |
1 |
1 |
1 |
Biochemical Activity |
| RGI2 |
YIL057C |
Protein of unknown function |
physical |
1 |
1 |
1 |
Biochemical Activity |
| LIA1 |
YJR070C |
Deoxyhypusine hydroxylase |
physical |
1 |
1 |
1 |
PCA |
| NAB2 |
YGL122C |
Nuclear polyadenylated RNA-binding protein |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| KCC4 |
YCL024W |
Protein kinase of the bud neck involved in the septin checkpoint |
physical |
1 |
1 |
1 |
PCA |
| MOB1 |
YIL106W |
Component of the mitotic exit network |
physical |
1 |
1 |
1 |
PCA |
| MOB1 |
YIL106W |
Component of the mitotic exit network |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| MSB4 |
YOL112W |
GTPase-activating protein of the Ras superfamily |
physical |
1 |
1 |
1 |
PCA |
| NBP2 |
YDR162C |
Protein involved in the HOG (high osmolarity glycerol) pathway |
physical |
1 |
1 |
1 |
PCA |
| PTC1 |
YDL006W |
Type 2C protein phosphatase (PP2C) |
physical |
1 |
1 |
1 |
PCA |
| LAS17 |
YOR181W |
Actin assembly factor |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| LAS17 |
YOR181W |
Actin assembly factor |
genetic |
1 |
1 |
1 |
Positive Genetic |
| LSC2 |
YGR244C |
Beta subunit of succinyl-CoA ligase |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| REV7 |
YIL139C |
Accessory subunit of DNA polymerase zeta |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| VMA13 |
YPR036W |
Subunit H of the V1 peripheral membrane domain of V-ATPase |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| YGR017W |
YGR017W |
Putative protein of unknown function |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| PEX35 |
YGR168C |
Regulator of peroxisome abundance |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| YIG1 |
YPL201C |
Protein that interacts with glycerol 3-phosphatase |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| PAT1 |
YCR077C |
Deadenylation-dependent mRNA-decapping factor |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| PAT1 |
YCR077C |
Deadenylation-dependent mRNA-decapping factor |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SBP1 |
YHL034C |
Protein that binds eIF4G and has a role in repression of translation |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| VAM6 |
YDL077C |
Guanine nucleotide exchange factor for the GTPase Gtr1p |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| PUF2 |
YPR042C |
PUF family mRNA-binding protein |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| ISW1 |
YBR245C |
ATPase subunit of imitation-switch (ISWI) class chromatin remodelers |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| RIO1 |
YOR119C |
Serine kinase involved in cell cycle regulation and rDNA integrity |
physical |
1 |
1 |
1 |
Two-hybrid |
| SSD1 |
YDR293C |
Translational repressor |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| SSD1 |
YDR293C |
Translational repressor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SWI1 |
YPL016W |
Subunit of the SWI/SNF chromatin remodeling complex |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| RPD3 |
YNL330C |
Histone deacetylase, component of both the Rpd3S and Rpd3L complexes |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| RET1 |
YOR207C |
Second-largest subunit of RNA polymerase III |
genetic |
1 |
1 |
1 |
Negative Genetic |
| OPI3 |
YJR073C |
Methylene-fatty-acyl-phospholipid synthase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| IWR1 |
YDL115C |
RNA polymerase II transport factor, conserved from yeast to humans |
genetic |
1 |
1 |
1 |
Negative Genetic |
| LSM7 |
YNL147W |
Lsm (Like Sm) protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| STB5 |
YHR178W |
Transcription factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SPT21 |
YMR179W |
Protein with a role in transcriptional silencing |
genetic |
1 |
1 |
1 |
Positive Genetic |
| RSC8 |
YFR037C |
Component of the RSC chromatin remodeling complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| TEC1 |
YBR083W |
Transcription factor targeting filamentation genes and Ty1 expression |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| SCS2 |
YER120W |
Integral ER membrane protein, regulates phospholipid metabolism |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| TOR1 |
YJR066W |
PIK-related protein kinase and rapamycin target |
genetic |
1 |
1 |
1 |
Positive Genetic |
| REI1 |
YBR267W |
Cytoplasmic pre-60S factor |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| SBA1 |
YKL117W |
Co-chaperone that binds and regulates Hsp90 family chaperones |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| SSN8 |
YNL025C |
Cyclin-like component of RNA polymerase II holoenzyme |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TPK3 |
YKL166C |
cAMP-dependent protein kinase catalytic subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
| KCS1 |
YDR017C |
Inositol hexakisphosphate and inositol heptakisphosphate kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| LCB5 |
YLR260W |
Minor sphingoid long-chain base kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PLM2 |
YDR501W |
Putative transcription factor, contains Forkhead Associated domain |
genetic |
1 |
1 |
1 |
Positive Genetic |
| RAD17 |
YOR368W |
Checkpoint protein |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SSN3 |
YPL042C |
Component of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MSN4 |
YKL062W |
Stress-responsive transcriptional activator |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RIM15 |
YFL033C |
Protein kinase involved in cell proliferation in response to nutrients |
genetic |
1 |
1 |
1 |
Negative Genetic |
| KDX1 |
YKL161C |
Protein kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| IXR1 |
YKL032C |
Transcriptional repressor that regulates hypoxic genes during normoxia |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SWR1 |
YDR334W |
Swi2/Snf2-related ATPase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SWI6 |
YLR182W |
Transcription cofactor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PHO23 |
YNL097C |
Component of the Rpd3L histone deacetylase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YVH1 |
YIR026C |
Dual specificity protein phosphatase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SAT4 |
YCR008W |
Ser/Thr protein kinase involved in salt tolerance, nutrient response |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PGA3 |
YML125C |
Putative cytochrome b5 reductase, localized to the plasma membrane |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SPT10 |
YJL127C |
Histone H3 acetylase with a role in transcriptional regulation |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| POG1 |
YIL122W |
DNA-binding transcriptional activator |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
| MSA1 |
YOR066W |
Activator of G1-specific transcription factors MBF and SBF |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
| YHP1 |
YDR451C |
Homeobox transcriptional repressor |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
| KEL2 |
YGR238C |
Protein that negatively regulates mitotic exit |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
| ZRG8 |
YER033C |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
| YPR015C |
YPR015C |
Putative zinc finger transcription factor |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
| SLK19 |
YOR195W |
Kinetochore-associated protein |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
| WHI4 |
YDL224C |
Putative RNA binding protein |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
| RED1 |
YLR263W |
Protein component of the synaptonemal complex axial elements |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
| ZRG17 |
YNR039C |
Endoplasmic reticulum zinc transporter |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
| UBP7 |
YIL156W |
Ubiquitin-specific protease that cleaves ubiquitin-protein fusions |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
| USE1 |
YGL098W |
Essential SNARE protein localized to the ER |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SGT1 |
YOR057W |
Cochaperone protein |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SOM1 |
YEL059C-A |
Subunit of the mitochondrial inner membrane peptidase (IMP) |
genetic |
1 |
1 |
1 |
Positive Genetic |
| TUS1 |
YLR425W |
Guanine nucleotide exchange factor (GEF) that modulates Rho1p activity |
genetic |
1 |
1 |
1 |
Positive Genetic |
| NIP100 |
YPL174C |
Large subunit of the dynactin complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| TAF5 |
YBR198C |
Subunit (90 kDa) of TFIID and SAGA complexes |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SRB6 |
YBR253W |
Subunit of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| UBC1 |
YDR177W |
Ubiquitin-conjugating enzyme |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MCM3 |
YEL032W |
Protein involved in DNA replication |
genetic |
1 |
1 |
1 |
Negative Genetic |
| POL5 |
YEL055C |
Protein involved in 60S assembly and pre-40S AFs recycling |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PMI40 |
YER003C |
Mannose-6-phosphate isomerase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PAB1 |
YER165W |
Poly(A) binding protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NUP57 |
YGR119C |
FG-nucleoporin component of central core of the nuclear pore complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| OKP1 |
YGR179C |
Outer kinetochore protein required for accurate chromosome segregation |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TAO3 |
YIL129C |
Component of the RAM signaling network |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NOP9 |
YJL010C |
Essential subunit of U3-containing 90S preribosome |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RFA3 |
YJL173C |
Subunit of heterotrimeric Replication Protein A (RPA) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| LSM8 |
YJR022W |
Lsm (Like Sm) protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RGR1 |
YLR071C |
Subunit of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| POP1 |
YNL221C |
Subunit of RNase MRP, nuclear RNase P and telomerase complexes |
genetic |
1 |
1 |
1 |
Negative Genetic |
| POL2 |
YNL262W |
Catalytic subunit of DNA polymerase (II) epsilon |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RFA2 |
YNL312W |
Subunit of heterotrimeric Replication Protein A (RPA) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPT5 |
YOR117W |
ATPase of the 19S regulatory particle of the 26S proteasome |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SMP3 |
YOR149C |
Alpha 1,2-mannosyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPT4 |
YOR259C |
ATPase of the 19S regulatory particle of the 26S proteasome |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SOG2 |
YOR353C |
Key component of the RAM signaling network |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ORC2 |
YBR060C |
Subunit of the origin recognition complex (ORC) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPB7 |
YDR404C |
RNA polymerase II subunit B16 |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPN11 |
YFR004W |
Metalloprotease subunit of 19S regulatory particle |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPT6 |
YGL048C |
ATPase of the 19S regulatory particle of the 26S proteasome |
genetic |
1 |
1 |
1 |
Negative Genetic |
| STS1 |
YIR011C |
Protein required for localizing proteasomes to the nucleus |
genetic |
1 |
1 |
1 |
Negative Genetic |
| POL31 |
YJR006W |
Subunit of DNA polymerase delta (polymerase III) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TIM23 |
YNR017W |
Essential component of the TIM23 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SMP1 |
YBR182C |
MADS-box transcription factor involved in osmotic stress response |
genetic |
1 |
1 |
1 |
Negative Genetic |
| OST4 |
YDL232W |
Subunit of the oligosaccharyltransferase complex of the ER lumen |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PMT7 |
YDR307W |
Putative protein mannosyltransferase similar to Pmt1p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PXP1 |
YEL020C |
Peroxisomal matrix protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MGA2 |
YIR033W |
ER membrane protein involved in regulation of OLE1 transcription |
genetic |
1 |
1 |
1 |
Negative Genetic |
| IML1 |
YJR138W |
GTPase-activating protein (GAP) subunit of the Iml1p/SEACIT complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MRC1 |
YCL061C |
S-phase checkpoint protein required for DNA replication |
genetic |
1 |
1 |
1 |
Negative Genetic |
| XRS2 |
YDR369C |
FHA domain-containing component of the Mre11 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPS26B |
YER131W |
Protein component of the small (40S) ribosomal subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RTG2 |
YGL252C |
Sensor of mitochondrial dysfunction |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SMN1 |
YHR202W |
Putative AMP hydrolase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RCY1 |
YJL204C |
F-box protein involved in recycling endocytosed proteins |
genetic |
1 |
1 |
1 |
Negative Genetic |
| VPS9 |
YML097C |
Guanine nucleotide exchange factor (GEF) and ubiquitin receptor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| THP3 |
YPR045C |
Protein that may have a role in transcription elongation |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TDA5 |
YLR426W |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MIX17 |
YMR002W |
Mitochondrial intermembrane space protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PSO2 |
YMR137C |
Nuclease required for DNA single- and double-strand break repair |
genetic |
1 |
1 |
1 |
Negative Genetic |
| VAC7 |
YNL054W |
Integral vacuolar membrane protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SLA2 |
YNL243W |
Adaptor protein that links actin to clathrin and endocytosis |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MCH4 |
YOL119C |
Protein with similarity to mammalian monocarboxylate permeases |
genetic |
1 |
1 |
1 |
Negative Genetic |
| IFM1 |
YOL023W |
Mitochondrial translation initiation factor 2 |
genetic |
1 |
1 |
1 |
Positive Genetic |
| RAD54 |
YGL163C |
DNA-dependent ATPase that stimulates strand exchange |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TPM1 |
YNL079C |
Major isoform of tropomyosin |
genetic |
1 |
1 |
1 |
Positive Genetic |
| UBP12 |
YJL197W |
Ubiquitin-specific protease |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RAD57 |
YDR004W |
Protein that stimulates strand exchange |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SEC61 |
YLR378C |
Conserved ER protein translocation channel |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SUB1 |
YMR039C |
Transcriptional regulator |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TFC3 |
YAL001C |
Subunit of RNA polymerase III transcription initiation factor complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| STU1 |
YBL034C |
Microtubule plus-end-tracking non-motor protein |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SEA4 |
YBL104C |
Subunit of SEACAT, a subcomplex of the SEA complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SWC5 |
YBR231C |
Component of the SWR1 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YCR050C |
YCR050C |
Non-essential protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| THR4 |
YCR053W |
Threonine synthase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NSE4 |
YDL105W |
Component of the SMC5-SMC6 complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| RAD55 |
YDR076W |
Protein that stimulates strand exchange |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TAF12 |
YDR145W |
Subunit (61/68 kDa) of TFIID and SAGA complexes |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MSC2 |
YDR205W |
Endoplasmic reticulum zinc transporter |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TRS23 |
YDR246W |
Core component of transport protein particle (TRAPP) complexes I-III |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MCM21 |
YDR318W |
Component of the kinetochore sub-complex COMA |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SPT3 |
YDR392W |
Subunit of the SAGA and SAGA-like transcriptional regulatory complexes |
genetic |
1 |
1 |
1 |
Negative Genetic |
| KRE28 |
YDR532C |
Subunit of a kinetochore-microtubule binding complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| HUR1 |
YGL168W |
Protein with a role in DNA repair |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SLX9 |
YGR081C |
Protein required for pre-rRNA processing |
genetic |
1 |
1 |
1 |
Positive Genetic |
| PHB2 |
YGR231C |
Subunit of the prohibitin complex (Phb1p-Phb2p) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| IRE1 |
YHR079C |
Serine-threonine kinase and endoribonuclease |
genetic |
1 |
1 |
1 |
Positive Genetic |
| NEO1 |
YIL048W |
Phospholipid translocase (flippase) |
genetic |
1 |
1 |
1 |
Positive Genetic |
| VTC4 |
YJL012C |
Vacuolar membrane polyphosphate polymerase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SMC3 |
YJL074C |
Subunit of the multiprotein cohesin complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPS21B |
YJL136C |
Protein component of the small (40S) ribosomal subunit |
genetic |
1 |
1 |
1 |
Positive Genetic |
| VPS35 |
YJL154C |
Endosomal subunit of membrane-associated retromer complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SSL1 |
YLR005W |
Subunit of the core form of RNA polymerase transcription factor TFIIH |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPS0B |
YLR048W |
Protein component of the small (40S) ribosomal subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TAG1 |
YLR173W |
Vacuolar membrane protein involved in termination of autophagy |
genetic |
1 |
1 |
1 |
Negative Genetic |
| VRP1 |
YLR337C |
Verprolin, proline-rich actin-associated protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| VAC14 |
YLR386W |
Enzyme regulator |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NSE5 |
YML023C |
Component of the SMC5-SMC6 complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| PDS5 |
YMR076C |
Cohesion maintenance factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SGS1 |
YMR190C |
RecQ family nucleolar DNA helicase |
genetic |
1 |
1 |
1 |
Positive Genetic |
| MRE11 |
YMR224C |
Nuclease subunit of the MRX complex with Rad50p and Xrs2p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NST1 |
YNL091W |
Translational inhibitor and suppressor of proteasome-assembly defects |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SEC12 |
YNR026C |
Guanine nucleotide exchange factor (GEF) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MET22 |
YOL064C |
Bisphosphate-3'-nucleotidase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MGE1 |
YOR232W |
Mitochondrial matrix cochaperone |
genetic |
1 |
1 |
1 |
Positive Genetic |
| LGE1 |
YPL055C |
Protein involved in histone H2B ubiquitination |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPL21B |
YPL079W |
Ribosomal 60S subunit protein L21B |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPL43A |
YPR043W |
Ribosomal 60S subunit protein L43A |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NUT2 |
YPR168W |
Subunit of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SWT1 |
YOR166C |
RNA endoribonuclease involved in perinuclear mRNP quality control |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SPC105 |
YGL093W |
Subunit of a kinetochore-microtubule binding complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SRS2 |
YJL092W |
DNA helicase and DNA-dependent ATPase |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SEY1 |
YOR165W |
Dynamin-like GTPase that mediates homotypic ER fusion |
genetic |
1 |
1 |
1 |
Positive Genetic |
| KRE5 |
YOR336W |
Protein required for beta-1,6 glucan biosynthesis |
genetic |
1 |
1 |
1 |
Positive Genetic |
| RVS161 |
YCR009C |
Amphiphysin-like lipid raft protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ICE2 |
YIL090W |
Integral ER membrane protein with type-III transmembrane domains |
genetic |
1 |
1 |
1 |
Negative Genetic |
| KES1 |
YPL145C |
Sterol/phosphatidylinositol-4-phosphate (PI(4)P) exchanger |
genetic |
1 |
1 |
1 |
Negative Genetic |
| VPS38 |
YLR360W |
Part of a Vps34p phosphatidylinositol 3-kinase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PEP8 |
YJL053W |
Vacuolar protein component of the retromer |
genetic |
1 |
1 |
1 |
Negative Genetic |
| POM33 |
YLL023C |
Transmembrane nucleoporin |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NUP188 |
YML103C |
Subunit of the inner ring of the nuclear pore complex (NPC) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MTC1 |
YJL123C |
Protein of unknown function that may interact with ribosomes |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MDY2 |
YOL111C |
Protein involved in inserting tail-anchored proteins into ER membranes |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ILV1 |
YER086W |
Threonine deaminase, catalyzes first step in isoleucine biosynthesis |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YPC1 |
YBR183W |
Alkaline ceramidase |
genetic |
1 |
1 |
1 |
Positive Genetic |
| COG3 |
YER157W |
Essential component of the conserved oligomeric Golgi complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CMR1 |
YDL156W |
Nuclear protein with role in transcription, protein quality control |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| CMD1 |
YBR109C |
Calmodulin |
genetic |
1 |
1 |
1 |
Positive Genetic |
| ARP8 |
YOR141C |
Nuclear actin-related protein involved in chromatin remodeling |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| ARP8 |
YOR141C |
Nuclear actin-related protein involved in chromatin remodeling |
genetic |
1 |
1 |
1 |
Negative Genetic |
| GIM3 |
YNL153C |
Subunit of the heterohexameric cochaperone prefoldin complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| DOA4 |
YDR069C |
Ubiquitin hydrolase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DIG1 |
YPL049C |
MAP kinase-responsive inhibitor of the Ste12p transcription factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| GLE2 |
YER107C |
RNA export factor associated with the nuclear pore complex (NPC) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DAM1 |
YGR113W |
Essential subunit of the Dam1 complex (aka DASH complex) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| GPM1 |
YKL152C |
Tetrameric phosphoglycerate mutase |
physical |
1 |
1 |
1 |
Biochemical Activity |
| CDC25 |
YLR310C |
Membrane bound guanine nucleotide exchange factor |
genetic |
1 |
1 |
1 |
Positive Genetic |
| BRR1 |
YPR057W |
snRNP protein component of spliceosomal snRNPs |
genetic |
1 |
1 |
1 |
Positive Genetic |
| GCN5 |
YGR252W |
Catalytic subunit of ADA and SAGA histone acetyltransferase complexes |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| CCT7 |
YJL111W |
Subunit of the cytosolic chaperonin Cct ring complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CAM1 |
YPL048W |
One of two isoforms of the gamma subunit of eEF1B |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| ACE2 |
YLR131C |
Transcription factor required for septum destruction after cytokinesis |
genetic |
1 |
1 |
1 |
Positive Genetic |
| BCK1 |
YJL095W |
MAPKKK acting in the protein kinase C signaling pathway |
genetic |
1 |
1 |
1 |
Positive Genetic |
| ECM30 |
YLR436C |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Positive Genetic |
| DRE2 |
YKR071C |
Component of the cytosolic Fe-S protein assembly (CIA) machinery |
physical |
1 |
1 |
1 |
Biochemical Activity |
| HSE1 |
YHL002W |
Subunit of the endosomal Vps27p-Hse1p complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| HEK2 |
YBL032W |
RNA binding protein involved in asymmetric localization of ASH1 mRNA |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| AIM17 |
YHL021C |
Protein of unknown function |
physical |
1 |
1 |
1 |
Biochemical Activity |
| CDC13 |
YDL220C |
Single stranded DNA-binding protein found at TG1-3 telomere G-tails |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| CAF20 |
YOR276W |
Phosphoprotein of the mRNA cap-binding complex |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| CDC5 |
YMR001C |
Polo-like kinase required for mitotic exit |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| CMP2 |
YML057W |
Calcineurin A |
genetic |
1 |
1 |
1 |
Dosage Lethality |
| CNB1 |
YKL190W |
Calcineurin B |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
| FKH1 |
YIL131C |
Forkhead family transcription factor |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
| FDO1 |
YMR144W |
Protein involved in directionality of mating type switching |
genetic |
1 |
1 |
1 |
Negative Genetic |
| APM3 |
YBR288C |
Mu3-like subunit of the clathrin associated protein complex (AP-3) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CAF120 |
YNL278W |
Part of the CCR4-NOT transcriptional regulatory complex |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
| CLN1 |
YMR199W |
G1 cyclin involved in regulation of the cell cycle |
genetic |
1 |
1 |
1 |
Negative Genetic |
| FUM1 |
YPL262W |
Fumarase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CCT3 |
YJL014W |
Subunit of the cytosolic chaperonin Cct ring complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| EST1 |
YLR233C |
TLC1 RNA-associated factor involved in telomere length regulation |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| EST1 |
YLR233C |
TLC1 RNA-associated factor involved in telomere length regulation |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| CDC15 |
YAR019C |
Hippo-like kinase of the Mitotic Exit Network |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| HHT1 |
YBR010W |
Histone H3 |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| FUS3 |
YBL016W |
Mitogen-activated serine/threonine protein kinase involved in mating |
genetic |
1 |
1 |
1 |
Negative Genetic |
| BIR1 |
YJR089W |
Subunit of chromosomal passenger complex (CPC) |
physical |
1 |
1 |
1 |
Biochemical Activity |
| ESS1 |
YJR017C |
Peptidylprolyl-cis/trans-isomerase (PPIase) |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| HOF1 |
YMR032W |
F-BAR protein that regulates actin cytoskeleton organization |
physical |
1 |
1 |
1 |
Two-hybrid |
| HOF1 |
YMR032W |
F-BAR protein that regulates actin cytoskeleton organization |
genetic |
1 |
1 |
1 |
Positive Genetic |
| BUD27 |
YFL023W |
Unconventional prefoldin protein involved in translation initiation |
physical |
1 |
1 |
1 |
Biochemical Activity |
| ARP1 |
YHR129C |
Actin-related protein of the dynactin complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| ATG1 |
YGL180W |
Protein serine/threonine kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ECM31 |
YBR176W |
Ketopantoate hydroxymethyltransferase |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| BNI4 |
YNL233W |
Targeting subunit for Glc7p protein phosphatase |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| GTR1 |
YML121W |
Subunit of a TORC1-stimulating GTPase and the EGO/GSE complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| COG4 |
YPR105C |
Essential component of the conserved oligomeric Golgi complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| BOS1 |
YLR078C |
v-SNARE (vesicle specific SNAP receptor) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| COG6 |
YNL041C |
Component of the conserved oligomeric Golgi complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| COG5 |
YNL051W |
Component of the conserved oligomeric Golgi complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| DOC1 |
YGL240W |
Processivity factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| AMD1 |
YML035C |
AMP deaminase |
physical |
1 |
1 |
1 |
Biochemical Activity |
| CET1 |
YPL228W |
RNA 5'-triphosphatase involved in mRNA 5' capping |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ARP6 |
YLR085C |
Actin-related protein that binds nucleosomes |
genetic |
1 |
1 |
1 |
Positive Genetic |
| HPC2 |
YBR215W |
Subunit of the HIR complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| CPT1 |
YNL130C |
Cholinephosphotransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| BUB1 |
YGR188C |
Protein kinase involved in the cell cycle checkpoint into anaphase |
genetic |
1 |
1 |
1 |
Positive Genetic |
| BIK1 |
YCL029C |
Microtubule-associated protein |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
| GYP1 |
YOR070C |
Cis-golgi GTPase-activating protein (GAP) for yeast Rabs |
genetic |
1 |
1 |
1 |
Positive Genetic |
| FCP1 |
YMR277W |
Carboxy-terminal domain (CTD) phosphatase |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
| BUD6 |
YLR319C |
Actin- and formin-interacting protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CUS2 |
YNL286W |
Putative checkpoint factor in transcription |
physical |
1 |
1 |
1 |
Biochemical Activity |
| CCH1 |
YGR217W |
Voltage-gated high-affinity calcium channel |
genetic |
1 |
1 |
1 |
Positive Genetic |
| HHT2 |
YNL031C |
Histone H3 |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| HBT1 |
YDL223C |
Shmoo tip protein, substrate of Hub1p ubiquitin-like protein |
physical |
1 |
1 |
1 |
Biochemical Activity |
| ACM1 |
YPL267W |
Pseudosubstrate inhibitor of the APC/C |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| FLO8 |
YER109C |
Transcription factor |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| EAF7 |
YNL136W |
Subunit of the NuA4 histone acetyltransferase complex |
physical |
1 |
1 |
1 |
Biochemical Activity |
| CAT2 |
YML042W |
Carnitine acetyl-CoA transferase |
physical |
1 |
1 |
1 |
Biochemical Activity |
| BTS1 |
YPL069C |
Geranylgeranyl diphosphate synthase (GGPPS) |
genetic |
1 |
1 |
1 |
Positive Genetic |
| CSF1 |
YLR087C |
Protein with structural similarity to lipid transport protein Vps13p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ERI1 |
YPL096C-A |
Endoplasmic reticulum membrane protein that binds and inhibits Ras2p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ANB1 |
YJR047C |
Translation elongation factor eIF-5A |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| CYK3 |
YDL117W |
SH3-domain protein located in the bud neck and cytokinetic actin ring |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CSH1 |
YBR161W |
Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
| FLO11 |
YIR019C |
GPI-anchored cell surface glycoprotein (flocculin) |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| GLN4 |
YOR168W |
Glutamine tRNA synthetase |
physical |
1 |
1 |
1 |
Biochemical Activity |
| CSA1 |
YPR174C |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
| ABP140 |
YOR239W |
AdoMet-dependent tRNA methyltransferase and actin binding protein |
physical |
1 |
1 |
1 |
Biochemical Activity |
| APJ1 |
YNL077W |
Hsp40 chaperone with a role in SUMO-mediated protein degradation |
physical |
1 |
1 |
1 |
Biochemical Activity |
| CCW22 |
YDR134C |
Cell wall protein |
physical |
1 |
1 |
1 |
Biochemical Activity |
| ADD37 |
YMR184W |
Protein of unknown function |
physical |
1 |
1 |
1 |
Biochemical Activity |
| EMC4 |
YGL231C |
Member of conserved ER transmembrane complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DER1 |
YBR201W |
ER membrane protein that promotes export of misfolded polypeptides |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CDC50 |
YCR094W |
Endosomal protein that interacts with phospholipid flippase Drs2p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| HIT1 |
YJR055W |
Protein involved in C/D snoRNP assembly |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ASI2 |
YNL159C |
Subunit of the inner nuclear membrane Asi ubiquitin ligase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ALG14 |
YBR070C |
Component of UDP-GlcNAc transferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DYN3 |
YMR299C |
Dynein light intermediate chain (LIC) |
genetic |
1 |
1 |
1 |
Positive Genetic |
| GPI13 |
YLL031C |
ER membrane localized phosphoryltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CDC8 |
YJR057W |
Nucleoside monophosphate and nucleoside diphosphate kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DPL1 |
YDR294C |
Dihydrosphingosine phosphate lyase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ERD1 |
YDR414C |
Predicted membrane protein required for lumenal ER protein retention |
genetic |
1 |
1 |
1 |
Negative Genetic |
| GLD1 |
YPR109W |
Component of Dsc E3 ligase complex in Golgi and endosomes |
genetic |
1 |
1 |
1 |
Negative Genetic |
| GPI15 |
YNL038W |
Protein involved in the synthesis of GlcNAc-PI |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ATP23 |
YNR020C |
Putative metalloprotease of the mitochondrial inner membrane |
genetic |
1 |
1 |
1 |
Positive Genetic |
| GPI11 |
YDR302W |
ER membrane protein involved in a late step of GPI anchor assembly |
genetic |
1 |
1 |
1 |
Negative Genetic |
