Standard name Systematic name Name description Description
DMA1 YHR115C Ubiquitin-protein ligase (E3) Ubiquitin-protein ligase (E3); controls septin dynamics, spindle position checkpoint (SPOC) with ligase Dma2p by regulating recruitment of Elm1p to bud neck; regulates levels of eIF2 subunit Gcd11p, as well as abundance, localization, and ubiquitination of Cdk inhibitory kinase Swe1p; ubiquitinates cyclin Pcl1p; ortholog of human RNF8, similar to human Chfr; contains FHA, RING fingers; DMA1 has a paralog, DMA2, that arose from the whole genome duplication
Visualize the interactome of DMA1
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.947 0.981 0.972
Mito 0.077 NaN NaN

GFP localization & abundance

GFP localization GFP abundance
no data no data

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
DMA1 3 2 2 2 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
DMA2 YNL116W Ubiquitin-protein ligase (E3) genetic 10 5 10 Synthetic Growth Defect, Negative Genetic, Phenotypic Suppression, Synthetic Lethality, Negative Genetic, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Growth Defect
CDC123 YLR215C Assembly factor for the eIF2 translation initiation factor complex physical 4 2 3 Two-hybrid, Two-hybrid, Affinity Capture-Western, Two-hybrid
PHO85 YPL031C Cyclin-dependent kinase physical 3 2 3 Biochemical Activity, Biochemical Activity, Affinity Capture-Western
BNI1 YNL271C Formin genetic 3 3 2 Synthetic Lethality, Synthetic Growth Defect, Phenotypic Enhancement
DMA2 YNL116W Ubiquitin-protein ligase (E3) physical 3 2 2 Affinity Capture-MS, Biochemical Activity, Biochemical Activity
PCL1 YNL289W Cyclin, interacts with cyclin-dependent kinase Pho85p physical 3 2 2 Biochemical Activity, Affinity Capture-Western, Biochemical Activity
DYN1 YKR054C Cytoplasmic heavy chain dynein genetic 3 2 2 Synthetic Lethality, Synthetic Lethality, Phenotypic Enhancement
CDC55 YGL190C Regulatory subunit B of protein phosphatase 2A (PP2A) genetic 2 2 2 Positive Genetic, Synthetic Lethality
ESC2 YDR363W Sumo-like domain protein genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
SWE1 YJL187C Protein kinase that regulates the G2/M transition genetic 2 2 2 Synthetic Rescue, Phenotypic Suppression
FKH1 YIL131C Forkhead family transcription factor regulation 2 1 2 chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation-chip evidence
KSP1 YHR082C Serine/threonine protein kinase genetic 2 1 2 Negative Genetic, Negative Genetic
HSL1 YKL101W Nim1p-related protein kinase genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
DIA2 YOR080W Origin-binding F-box protein genetic 2 1 2 Synthetic Growth Defect, Synthetic Growth Defect
CLA4 YNL298W Cdc42p-activated signal transducing kinase genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
SAE2 YGL175C Endonuclease required for telomere elongation physical 2 2 1 Affinity Capture-MS, Protein-peptide
SLD2 YKL108W Single-stranded DNA origin-binding and annealing protein physical 2 2 1 Two-hybrid, Reconstituted Complex
ELM1 YKL048C Serine/threonine protein kinase genetic 2 2 1 Synthetic Lethality, Synthetic Rescue
RTS1 YOR014W B-type regulatory subunit of protein phosphatase 2A (PP2A) genetic 2 2 1 Synthetic Rescue, Synthetic Lethality
IQG1 YPL242C Actin filament binding protein that enhances actin ring formation genetic 2 2 1 Dosage Growth Defect, Dosage Lethality
RHO1 YPR165W GTP-binding protein of the rho subfamily of Ras-like proteins genetic 2 2 1 Synthetic Rescue, Phenotypic Suppression
SKP2 YNL311C F-box protein of unknown function physical 2 1 1 Affinity Capture-MS, Affinity Capture-MS
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
YAP1 YML007W Basic leucine zipper (bZIP) transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
ABF1 YKL112W DNA binding protein with possible chromatin-reorganizing activity regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MED4 YOR174W Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
RSF2 YJR127C Zinc-finger protein regulation 1 1 1 chromatin immunoprecipitation-chip evidence
DBP3 YGL078C RNA-Dependent ATPase, member of DExD/H-box family physical 1 1 1 Affinity Capture-MS
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit genetic 1 1 1 Dosage Lethality
CDC11 YJR076C Component of the septin ring that is required for cytokinesis genetic 1 1 1 Dosage Rescue
CDC12 YHR107C Component of the septin ring that is required for cytokinesis genetic 1 1 1 Synthetic Lethality
BNI1 YNL271C Formin physical 1 1 1 Affinity Capture-Western
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
CRM1 YGR218W Nuclear export factor, exportin physical 1 1 1 Affinity Capture-MS
AIM41 YOR215C Protein of unknown function physical 1 1 1 Two-hybrid
CLN1 YMR199W G1 cyclin involved in regulation of the cell cycle genetic 1 1 1 Negative Genetic
YEF1 YEL041W ATP-NADH kinase physical 1 1 1 Two-hybrid
GCD11 YER025W Gamma subunit of the translation initiation factor eIF2 physical 1 1 1 Affinity Capture-MS
JIP5 YPR169W Protein required for biogenesis of the large ribosomal subunit physical 1 1 1 Affinity Capture-MS
MKT1 YNL085W Protein similar to nucleases that forms a complex with Pbp1p physical 1 1 1 Affinity Capture-MS
SEC16 YPL085W COPII vesicle coat protein required for ER transport vesicle budding physical 1 1 1 Affinity Capture-MS
YLR410W-B YLR410W-B Retrotransposon TYA Gag and TYB Pol genes physical 1 1 1 Affinity Capture-MS
YGR161W-B YGR161W-B Retrotransposon TYA Gag and TYB Pol genes physical 1 1 1 Affinity Capture-MS
YFL002W-A YFL002W-A Retrotransposon TYA Gag and TYB Pol genes physical 1 1 1 Affinity Capture-MS
YDR210W-B YDR210W-B Retrotransposon TYA Gag and TYB Pol genes physical 1 1 1 Affinity Capture-MS
YDR034C-D YDR034C-D Retrotransposon TYA Gag and TYB Pol genes physical 1 1 1 Affinity Capture-MS
YCL019W YCL019W Retrotransposon TYA Gag and TYB Pol genes physical 1 1 1 Affinity Capture-MS
YJR026W YJR026W Retrotransposon TYA Gag gene co-transcribed with TYB Pol physical 1 1 1 Affinity Capture-MS
YOL103W-A YOL103W-A Retrotransposon TYA Gag gene co-transcribed with TYB Pol physical 1 1 1 Affinity Capture-MS
YML040W YML040W Retrotransposon TYA Gag gene co-transcribed with TYB Pol physical 1 1 1 Affinity Capture-MS
YLR256W-A YLR256W-A Retrotransposon TYA Gag gene co-transcribed with TYB Pol physical 1 1 1 Affinity Capture-MS
YLR227W-A YLR227W-A Retrotransposon TYA Gag gene co-transcribed with TYB Pol physical 1 1 1 Affinity Capture-MS
YLR157C-A YLR157C-A Retrotransposon TYA Gag gene co-transcribed with TYB Pol physical 1 1 1 Affinity Capture-MS
YJR028W YJR028W Retrotransposon TYA Gag gene co-transcribed with TYB Pol physical 1 1 1 Affinity Capture-MS
HEK2 YBL032W RNA binding protein involved in asymmetric localization of ASH1 mRNA physical 1 1 1 Affinity Capture-RNA
DMA1 YHR115C Ubiquitin-protein ligase (E3) physical 1 1 1 Biochemical Activity
UBC4 YBR082C Ubiquitin-conjugating enzyme (E2) physical 1 1 1 Reconstituted Complex
UBC13 YDR092W E2 ubiquitin-conjugating enzyme physical 1 1 1 Reconstituted Complex
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
VAC17 YCL063W Phosphoprotein involved in vacuole inheritance physical 1 1 1 Reconstituted Complex
SAE2 YGL175C Endonuclease required for telomere elongation genetic 1 1 1 Synthetic Lethality
TIF4631 YGR162W Translation initiation factor eIF4G and scaffold protein physical 1 1 1 Affinity Capture-MS
RAD53 YPL153C DNA damage response kinase physical 1 1 1 Affinity Capture-Western
HTA1 YDR225W Histone H2A physical 1 1 1 Affinity Capture-Western
GET2 YER083C Subunit of the GET complex genetic 1 1 1 Negative Genetic
GIM3 YNL153C Subunit of the heterohexameric cochaperone prefoldin complex genetic 1 1 1 Negative Genetic
TEX1 YNL253W Protein involved in mRNA export genetic 1 1 1 Negative Genetic
YPD1 YDL235C Osmotic stress-responsive phosphorelay intermediate sensor protein genetic 1 1 1 Positive Genetic
PTC7 YHR076W Type 2C serine/threonine protein phosphatase (PP2C) genetic 1 1 1 Negative Genetic
INP52 YNL106C Polyphosphatidylinositol phosphatase genetic 1 1 1 Negative Genetic
UFD4 YKL010C Ubiquitin-protein ligase (E3) genetic 1 1 1 Phenotypic Enhancement
SET2 YJL168C Histone methyltransferase with a role in transcriptional elongation genetic 1 1 1 Synthetic Growth Defect
MIH1 YMR036C Protein tyrosine phosphatase genetic 1 1 1 Synthetic Lethality
PTC1 YDL006W Type 2C protein phosphatase (PP2C) genetic 1 1 1 Positive Genetic
RSC2 YLR357W Component of the RSC chromatin remodeling complex genetic 1 1 1 Negative Genetic
IRE1 YHR079C Serine-threonine kinase and endoribonuclease genetic 1 1 1 Negative Genetic
NUP133 YKR082W Subunit of Nup84p subcomplex of nuclear pore complex (NPC) genetic 1 1 1 Negative Genetic
GIN4 YDR507C Protein kinase involved in bud growth and assembly of the septin ring genetic 1 1 1 Synthetic Lethality
SHS1 YDL225W Component of the septin ring that is required for cytokinesis genetic 1 1 1 Synthetic Lethality
KIN4 YOR233W Serine/threonine protein kinase genetic 1 1 1 Phenotypic Suppression
POG1 YIL122W DNA-binding transcriptional activator genetic 1 1 1 Dosage Growth Defect
GIC1 YHR061C Rho-family GTPase interacting protein and Cdc42p effector genetic 1 1 1 Synthetic Growth Defect
GIC2 YDR309C Rho-family GTPase interacting protein and Cdc42p effector genetic 1 1 1 Synthetic Growth Defect
PKC1 YBL105C Protein serine/threonine kinase genetic 1 1 1 Synthetic Rescue
SYP1 YCR030C Negative regulator of WASP-Arp23 complex genetic 1 1 1 Synthetic Rescue
PMA1 YGL008C Plasma membrane P2-type H+-ATPase genetic 1 1 1 Negative Genetic
RAD9 YDR217C DNA damage-dependent checkpoint protein genetic 1 1 1 Synthetic Rescue
CDC123 YLR215C Assembly factor for the eIF2 translation initiation factor complex genetic 1 1 1 Synthetic Rescue
BIR1 YJR089W Subunit of chromosomal passenger complex (CPC) genetic 1 1 1 Positive Genetic
APM4 YOL062C Cargo-binding mu subunit of AP-2 physical 1 1 1 Two-hybrid
BIM1 YER016W Microtubule plus end-tracking protein genetic 1 1 1 Synthetic Lethality
BNI4 YNL233W Targeting subunit for Glc7p protein phosphatase genetic 1 1 1 Synthetic Rescue
BNI5 YNL166C Linker protein responsible for recruitment of myosin to the bud neck genetic 1 1 1 Phenotypic Suppression
BNR1 YIL159W Formin physical 1 1 1 Affinity Capture-Western
CYK3 YDL117W SH3-domain protein located in the bud neck and cytokinetic actin ring genetic 1 1 1 Synthetic Growth Defect