Standard name Systematic name Name description Description
MIH1 YMR036C Protein tyrosine phosphatase Protein tyrosine phosphatase; involved in cell cycle control and retrograde protein transport; regulates the phosphorylation state of Cdc28p; modulates phosphorylation of retromer component Vps26p; homolog of S. pombe cdc25
Visualize the interactome of MIH1
Links to external databases:
SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.346 0.421 NaN
Mito 0.642 0.371 NaN
SpindlePole 0.050 NaN NaN
ER NaN 0.050 NaN
Endosome NaN 0.107 NaN
Vac/Vac Memb NaN 0.119 NaN

GFP localization & abundance

GFP localization GFP abundance
cytoplasm, nucleus low signal

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
MIH1 0 3 0 0 0

Enzyme information

Catalyzed reactions in Yeast8

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
HSL1 YKL101W Nim1p-related protein kinase genetic 16 4 11 Negative Genetic, Negative Genetic, Synthetic Rescue, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Rescue, Negative Genetic, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Lethality, Dosage Growth Defect, Negative Genetic, Negative Genetic
ELM1 YKL048C Serine/threonine protein kinase genetic 7 2 6 Negative Genetic, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SWE1 YJL187C Protein kinase that regulates the G2/M transition genetic 5 3 5 Phenotypic Suppression, Synthetic Rescue, Phenotypic Suppression, Synthetic Growth Defect, Synthetic Rescue
RTS1 YOR014W B-type regulatory subunit of protein phosphatase 2A (PP2A) genetic 5 2 4 Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Lethality, Negative Genetic
CDC11 YJR076C Component of the septin ring that is required for cytokinesis genetic 4 2 4 Phenotypic Enhancement, Negative Genetic, Negative Genetic, Negative Genetic
GIN4 YDR507C Protein kinase involved in bud growth and assembly of the septin ring genetic 4 2 4 Negative Genetic, Phenotypic Suppression, Negative Genetic, Negative Genetic
CDH1 YGL003C Activator of anaphase-promoting complex/cyclosome (APC/C) genetic 4 2 4 Negative Genetic, Synthetic Lethality, Negative Genetic, Negative Genetic
CDC55 YGL190C Regulatory subunit B of protein phosphatase 2A (PP2A) genetic 3 2 3 Negative Genetic, Synthetic Growth Defect, Negative Genetic
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit physical 3 1 3 Biochemical Activity, Biochemical Activity, Biochemical Activity
CDC23 YHR166C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
SEC22 YLR268W R-SNARE protein genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
APC5 YOR249C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
CDC27 YBL084C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
CKA2 YOR061W Alpha' catalytic subunit of casein kinase 2 (CK2) physical 2 2 2 Biochemical Activity, Affinity Capture-MS
HRR25 YPL204W Conserved casein kinase, monopolin subunit physical 2 2 2 Biochemical Activity, Affinity Capture-MS
CDC20 YGL116W Activator of anaphase-promoting complex/cyclosome (APC/C) genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
HSL7 YBR133C Protein arginine N-methyltransferase genetic 2 2 2 Synthetic Lethality, Negative Genetic
SLT2 YHR030C Serine/threonine MAP kinase genetic 2 2 2 Phenotypic Suppression, Synthetic Rescue
ZDS1 YMR273C Protein with a role in regulating Swe1p-dependent polarized growth genetic 2 2 2 Phenotypic Suppression, Negative Genetic
PKC1 YBL105C Protein serine/threonine kinase genetic 2 2 2 Positive Genetic, Dosage Rescue
SIN3 YOL004W Component of both the Rpd3S and Rpd3L histone deacetylase complexes genetic 2 2 2 Positive Genetic, Negative Genetic
MCK1 YNL307C Dual-specificity ser/thr and tyrosine protein kinase physical 2 2 2 Biochemical Activity, Affinity Capture-Western
MCK1 YNL307C Dual-specificity ser/thr and tyrosine protein kinase genetic 2 2 2 Dosage Lethality, Dosage Growth Defect
FKH1 YIL131C Forkhead family transcription factor regulation 2 1 2 chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation-chip evidence
CDC3 YLR314C Component of the septin ring that is required for cytokinesis genetic 2 1 2 Negative Genetic, Negative Genetic
CKS1 YBR135W Cyclin-dependent protein kinase regulatory subunit and adaptor genetic 2 1 2 Negative Genetic, Negative Genetic
ANP1 YEL036C Subunit of the alpha-1,6 mannosyltransferase complex genetic 2 1 2 Negative Genetic, Negative Genetic
CDC5 YMR001C Polo-like kinase required for mitotic exit physical 2 1 2 Biochemical Activity, Biochemical Activity
MNN10 YDR245W Subunit of a Golgi mannosyltransferase complex genetic 2 1 2 Negative Genetic, Negative Genetic
RPT1 YKL145W ATPase of the 19S regulatory particle of the 26S proteasome genetic 2 1 2 Negative Genetic, Negative Genetic
HUR1 YGL168W Protein with a role in DNA repair genetic 2 1 2 Negative Genetic, Negative Genetic
SWE1 YJL187C Protein kinase that regulates the G2/M transition regulation 2 2 1 co-immunoprecipitation evidence, qualitative western immunoblotting evidence
FUS3 YBL016W Mitogen-activated serine/threonine protein kinase involved in mating genetic 2 2 1 Synthetic Growth Defect, Phenotypic Enhancement
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit regulation 1 1 1 quantitative mass spectrometry evidence
BIK1 YCL029C Microtubule-associated protein regulation 1 1 1 qualitative western immunoblotting evidence
CKA1 YIL035C Alpha catalytic subunit of casein kinase 2 (CK2) physical 1 1 1 Biochemical Activity
EAF1 YDR359C Component of the NuA4 histone acetyltransferase complex genetic 1 1 1 Negative Genetic
COR1 YBL045C Core subunit of the ubiquinol-cytochrome c reductase complex physical 1 1 1 Affinity Capture-MS
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
EFT2 YDR385W Elongation factor 2 (EF-2), also encoded by EFT1 genetic 1 1 1 Negative Genetic
APC1 YNL172W Largest subunit of the Anaphase-Promoting Complex/Cyclosome genetic 1 1 1 Negative Genetic
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit genetic 1 1 1 Synthetic Rescue
CDC12 YHR107C Component of the septin ring that is required for cytokinesis genetic 1 1 1 Negative Genetic
CPR1 YDR155C Cytoplasmic peptidyl-prolyl cis-trans isomerase (cyclophilin) physical 1 1 1 Affinity Capture-MS
CTK1 YKL139W Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I) genetic 1 1 1 Positive Genetic
EDE1 YBL047C Scaffold protein involved in the formation of early endocytic sites genetic 1 1 1 Negative Genetic
GDI1 YER136W GDP dissociation inhibitor genetic 1 1 1 Positive Genetic
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
HTB2 YBL002W Histone H2B physical 1 1 1 Affinity Capture-MS
ISW1 YBR245C ATPase subunit of imitation-switch (ISWI) class chromatin remodelers physical 1 1 1 Affinity Capture-RNA
KEL1 YHR158C Protein required for proper cell fusion and cell morphology physical 1 1 1 Affinity Capture-MS
COG3 YER157W Essential component of the conserved oligomeric Golgi complex genetic 1 1 1 Negative Genetic
MAM33 YIL070C Acidic protein of the mitochondrial matrix physical 1 1 1 Affinity Capture-MS
CDC6 YJL194W Essential ATP-binding protein required for DNA replication genetic 1 1 1 Synthetic Lethality
DAL3 YIR032C Ureidoglycolate lyase genetic 1 1 1 Negative Genetic
CDC13 YDL220C Single stranded DNA-binding protein found at TG1-3 telomere G-tails genetic 1 1 1 Phenotypic Suppression
GAS1 YMR307W Beta-1,3-glucanosyltransferase required for cell wall assembly genetic 1 1 1 Negative Genetic
DMA2 YNL116W Ubiquitin-protein ligase (E3) genetic 1 1 1 Synthetic Lethality
DMA1 YHR115C Ubiquitin-protein ligase (E3) genetic 1 1 1 Synthetic Lethality
IPA1 YJR141W Protein implicated in pre-mRNA processing and proteasomal degradation genetic 1 1 1 Positive Genetic
KIN2 YLR096W S/T protein kinase physical 1 1 1 Affinity Capture-MS
CIK1 YMR198W Kinesin-associated protein genetic 1 1 1 Negative Genetic
QCR2 YPR191W Subunit 2 of ubiquinol cytochrome-c reductase (Complex III) physical 1 1 1 Affinity Capture-MS
ORC6 YHR118C Subunit of the origin recognition complex (ORC) physical 1 1 1 Two-hybrid
ORC2 YBR060C Subunit of the origin recognition complex (ORC) physical 1 1 1 Two-hybrid
ORC3 YLL004W Subunit of the origin recognition complex (ORC) physical 1 1 1 Two-hybrid
ORC5 YNL261W Subunit of the origin recognition complex (ORC) physical 1 1 1 Two-hybrid
YCK1 YHR135C Palmitoylated plasma membrane-bound casein kinase I (CK1) isoform physical 1 1 1 Biochemical Activity
YCK2 YNL154C Palmitoylated plasma membrane-bound casein kinase I (CK1) isoform physical 1 1 1 Biochemical Activity
YCK3 YER123W Palmitoylated vacuolar membrane-localized casein kinase I isoform physical 1 1 1 Biochemical Activity
SGV1 YPR161C Cyclin (Bur2p)-dependent protein kinase physical 1 1 1 Biochemical Activity
WHI3 YNL197C RNA binding protein that modulates mRNA stability physical 1 1 1 Protein-RNA
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-RNA
RPM2 YML091C Protein subunit of mitochondrial RNase P physical 1 1 1 Affinity Capture-MS
SLH1 YGR271W Subunit of ribosome-associated quality control trigger complex (RQT) physical 1 1 1 Affinity Capture-MS
TOR2 YKL203C PIK-related protein kinase and rapamycin target physical 1 1 1 Affinity Capture-MS
PRP19 YLL036C Splicing factor associated with the spliceosome physical 1 1 1 Two-hybrid
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
PPH21 YDL134C Catalytic subunit of protein phosphatase 2A, PP2A physical 1 1 1 Biochemical Activity
PPH21 YDL134C Catalytic subunit of protein phosphatase 2A, PP2A genetic 1 1 1 Synthetic Growth Defect
PPH22 YDL188C Catalytic subunit of protein phosphatase 2A, PP2A physical 1 1 1 Biochemical Activity
PPH22 YDL188C Catalytic subunit of protein phosphatase 2A, PP2A genetic 1 1 1 Synthetic Growth Defect
PEP8 YJL053W Vacuolar protein component of the retromer physical 1 1 1 Biochemical Activity
PEP8 YJL053W Vacuolar protein component of the retromer genetic 1 1 1 Negative Genetic
SWE1 YJL187C Protein kinase that regulates the G2/M transition physical 1 1 1 Affinity Capture-Western
PPZ1 YML016C Serine/threonine protein phosphatase Z, isoform of Ppz2p genetic 1 1 1 Negative Genetic
NDD1 YOR372C Transcriptional activator essential for nuclear division genetic 1 1 1 Synthetic Lethality
SHS1 YDL225W Component of the septin ring that is required for cytokinesis genetic 1 1 1 Negative Genetic
SRY1 YKL218C 3-hydroxyaspartate dehydratase genetic 1 1 1 Positive Genetic
ZDS2 YML109W Protein with a role in regulating Swe1p-dependent polarized growth genetic 1 1 1 Phenotypic Suppression
MMS1 YPR164W Subunit of E3 ubiquitin ligase complex involved in replication repair genetic 1 1 1 Negative Genetic
NPL3 YDR432W RNA-binding protein genetic 1 1 1 Synthetic Growth Defect
TAF1 YGR274C TFIID subunit, involved in RNA pol II transcription initiation genetic 1 1 1 Synthetic Lethality
RTG1 YOL067C Transcription factor (bHLH) involved in interorganelle communication genetic 1 1 1 Phenotypic Suppression
SOD2 YHR008C Mitochondrial manganese superoxide dismutase genetic 1 1 1 Phenotypic Suppression
SPT10 YJL127C Histone H3 acetylase with a role in transcriptional regulation genetic 1 1 1 Synthetic Rescue
TUB2 YFL037W Beta-tubulin genetic 1 1 1 Positive Genetic
SRV2 YNL138W CAP (cyclase-associated protein) genetic 1 1 1 Positive Genetic
SHG1 YBR258C Subunit of the COMPASS (Set1C) complex genetic 1 1 1 Positive Genetic
UPS1 YLR193C Phosphatidic acid transfer protein genetic 1 1 1 Positive Genetic
RRP17 YDR412W 5' exoribonuclease required for 5' end processing of pre-60S rRNA genetic 1 1 1 Negative Genetic
PMI40 YER003C Mannose-6-phosphate isomerase genetic 1 1 1 Negative Genetic
VHT1 YGR065C High-affinity plasma membrane H+-biotin (vitamin H) symporter genetic 1 1 1 Negative Genetic
UTP8 YGR128C Nucleolar protein required for export of tRNAs from the nucleus genetic 1 1 1 Negative Genetic
THS1 YIL078W Threonyl-tRNA synthetase genetic 1 1 1 Negative Genetic
POL31 YJR006W Subunit of DNA polymerase delta (polymerase III) genetic 1 1 1 Negative Genetic
RPT4 YOR259C ATPase of the 19S regulatory particle of the 26S proteasome genetic 1 1 1 Negative Genetic
TSC3 YBR058C-A Protein that stimulates the activity of serine palmitoyltransferase genetic 1 1 1 Negative Genetic
YDL180W YDL180W Putative protein of unknown function genetic 1 1 1 Negative Genetic
OST4 YDL232W Subunit of the oligosaccharyltransferase complex of the ER lumen genetic 1 1 1 Negative Genetic
TMA64 YDR117C Protein of unknown function that associates with ribosomes genetic 1 1 1 Negative Genetic
YGL114W YGL114W Putative protein of unknown function genetic 1 1 1 Negative Genetic
PTC1 YDL006W Type 2C protein phosphatase (PP2C) genetic 1 1 1 Dosage Rescue
YAR029W YAR029W Member of DUP240 gene family but contains no transmembrane domains genetic 1 1 1 Negative Genetic
STE50 YCL032W Adaptor protein for various signaling pathways genetic 1 1 1 Negative Genetic
UBP6 YFR010W Ubiquitin-specific protease genetic 1 1 1 Negative Genetic
TNA1 YGR260W High affinity nicotinic acid plasma membrane permease genetic 1 1 1 Negative Genetic
POL32 YJR043C Third subunit of DNA polymerase delta genetic 1 1 1 Negative Genetic
PDC1 YLR044C Major of three pyruvate decarboxylase isozymes genetic 1 1 1 Negative Genetic
RPL22A YLR061W Ribosomal 60S subunit protein L22A genetic 1 1 1 Negative Genetic
RPL6B YLR448W Ribosomal 60S subunit protein L6B genetic 1 1 1 Negative Genetic
SCJ1 YMR214W One of several homologs of bacterial chaperone DnaJ genetic 1 1 1 Negative Genetic
OCA1 YNL099C Putative protein tyrosine phosphatase genetic 1 1 1 Negative Genetic
SFL1 YOR140W Transcriptional repressor and activator genetic 1 1 1 Negative Genetic
VPS68 YOL129W Vacuolar membrane protein of unknown function genetic 1 1 1 Negative Genetic
YPL077C YPL077C Putative protein of unknown function genetic 1 1 1 Negative Genetic
RAD9 YDR217C DNA damage-dependent checkpoint protein genetic 1 1 1 Phenotypic Suppression
TPM1 YNL079C Major isoform of tropomyosin genetic 1 1 1 Positive Genetic
RPD3 YNL330C Histone deacetylase, component of both the Rpd3S and Rpd3L complexes genetic 1 1 1 Positive Genetic
PTP1 YDL230W Phosphotyrosine-specific protein phosphatase genetic 1 1 1 Synthetic Lethality
SLO1 YER180C-A Protein interacting with Arl3p genetic 1 1 1 Negative Genetic
SLA1 YBL007C Cytoskeletal protein binding protein genetic 1 1 1 Negative Genetic
TCP1 YDR212W Alpha subunit of chaperonin-containing T-complex genetic 1 1 1 Negative Genetic
UME6 YDR207C Rpd3L histone deacetylase complex subunit genetic 1 1 1 Negative Genetic
YDJ1 YNL064C Type I HSP40 co-chaperone genetic 1 1 1 Negative Genetic
SEC23 YPR181C GTPase-activating protein, stimulates the GTPase activity of Sar1p genetic 1 1 1 Negative Genetic
SSL1 YLR005W Subunit of the core form of RNA polymerase transcription factor TFIIH genetic 1 1 1 Negative Genetic
NST1 YNL091W Translational inhibitor and suppressor of proteasome-assembly defects genetic 1 1 1 Negative Genetic
NOP12 YOL041C Nucleolar protein involved in pre-25S rRNA processing genetic 1 1 1 Negative Genetic
RUD3 YOR216C Golgi matrix protein genetic 1 1 1 Negative Genetic
VPS38 YLR360W Part of a Vps34p phosphatidylinositol 3-kinase complex genetic 1 1 1 Negative Genetic
YJL118W YJL118W Protein of unknown function genetic 1 1 1 Negative Genetic
TUB4 YLR212C Gamma-tubulin genetic 1 1 1 Synthetic Rescue
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 1 1 1 Positive Genetic
ELG1 YOR144C Subunit of an alternative replication factor C complex genetic 1 1 1 Positive Genetic
IGO1 YNL157W Protein required for initiation of G0 program genetic 1 1 1 Synthetic Growth Defect
DAD1 YDR016C Essential subunit of the Dam1 complex (aka DASH complex) genetic 1 1 1 Negative Genetic
MAD2 YJL030W Component of the spindle-assembly checkpoint complex genetic 1 1 1 Phenotypic Suppression
CAK1 YFL029C Cyclin-dependent kinase-activating kinase genetic 1 1 1 Negative Genetic
CHA4 YLR098C DNA binding transcriptional activator genetic 1 1 1 Negative Genetic
KEG1 YFR042W Integral membrane protein of the ER genetic 1 1 1 Positive Genetic
APC11 YDL008W Catalytic core subunit, Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 1 1 1 Negative Genetic
DBF4 YDR052C Regulatory subunit of Cdc7p-Dbf4p kinase complex genetic 1 1 1 Negative Genetic
BIK1 YCL029C Microtubule-associated protein physical 1 1 1 Affinity Capture-Western
MGM1 YOR211C Mitochondrial GTPase, present in complex with Ugo1p and Fzo1p genetic 1 1 1 Negative Genetic
CSG2 YBR036C Endoplasmic reticulum membrane protein genetic 1 1 1 Negative Genetic
DID2 YKR035W-A Class E protein of the vacuolar protein-sorting (Vps) pathway genetic 1 1 1 Negative Genetic
CLB3 YDL155W B-type cyclin involved in cell cycle progression physical 1 1 1 Affinity Capture-MS
CSF1 YLR087C Protein with structural similarity to lipid transport protein Vps13p genetic 1 1 1 Negative Genetic
KEX1 YGL203C Cell death protease essential for hypochlorite-induced apoptosis genetic 1 1 1 Negative Genetic
GLO4 YOR040W Mitochondrial glyoxalase II genetic 1 1 1 Negative Genetic
HRQ1 YDR291W 3'-5' DNA helicase of the conserved RecQ family genetic 1 1 1 Positive Genetic
ACL4 YDR161W Specific assembly chaperone for ribosomal protein Rpl4a/Rpl4b genetic 1 1 1 Negative Genetic
DNF2 YDR093W Aminophospholipid translocase (flippase) genetic 1 1 1 Negative Genetic
COM2 YER130C Transcription factor that binds IME1 Upstream Activation Signal (UAS) genetic 1 1 1 Negative Genetic
IGO2 YHR132W-A Protein required for initiation of G0 program genetic 1 1 1 Synthetic Growth Defect
MAL33 YBR297W MAL-activator protein genetic 1 1 1 Negative Genetic
DGK1 YOR311C Diacylglycerol kinase genetic 1 1 1 Positive Genetic
HXT8 YJL214W Protein of unknown function with similarity to hexose transporters genetic 1 1 1 Negative Genetic
ECT1 YGR007W Ethanolamine-phosphate cytidylyltransferase genetic 1 1 1 Negative Genetic
KRE5 YOR336W Protein required for beta-1,6 glucan biosynthesis genetic 1 1 1 Negative Genetic