Standard name Systematic name Name description Description
PPZ1 YML016C Serine/threonine protein phosphatase Z, isoform of Ppz2p Serine/threonine protein phosphatase Z, isoform of Ppz2p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance
Visualize the interactome of PPZ1
Links to external databases:
SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Bud 0.077 0.083 0.057
Cell Periphery 0.629 0.643 0.625
Cort. Patches 0.464 0.317 0.265
Cytoplasm 0.134 0.296 0.304
ER 0.093 NaN NaN
Mito 0.072 NaN NaN

GFP localization & abundance

GFP localization GFP abundance
cytoplasm, cell periphery 217

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
PPZ1 0 0 0 0 0

Enzyme information

Catalyzed reactions in Yeast8

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
PPZ2 YDR436W Serine/threonine protein phosphatase Z, isoform of Ppz1p genetic 17 5 16 Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Lethality, Synthetic Lethality, Phenotypic Enhancement, Negative Genetic, Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Rescue, Negative Genetic, Phenotypic Enhancement, Negative Genetic, Phenotypic Enhancement, Synthetic Growth Defect
SLT2 YHR030C Serine/threonine MAP kinase genetic 12 6 9 Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Lethality, Negative Genetic, Negative Genetic, Dosage Rescue, Synthetic Growth Defect, Synthetic Rescue, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SIS2 YKR072C Negative regulatory subunit of protein phosphatase 1 (Ppz1p) physical 11 5 11 Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, PCA, Two-hybrid, Affinity Capture-MS, Reconstituted Complex, PCA, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex
SIS2 YKR072C Negative regulatory subunit of protein phosphatase 1 (Ppz1p) genetic 7 4 6 Dosage Rescue, Dosage Rescue, Synthetic Rescue, Dosage Rescue, Phenotypic Suppression, Positive Genetic, Dosage Rescue
BIM1 YER016W Microtubule plus end-tracking protein genetic 5 3 5 Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Synthetic Lethality, Negative Genetic
GCN2 YDR283C Protein kinase genetic 5 2 5 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Dosage Rescue
BCK1 YJL095W MAPKKK acting in the protein kinase C signaling pathway genetic 5 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
VIP1 YLR410W Bifunctional inositol pyrophosphate kinase and phosphatase genetic 5 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SDS22 YKL193C Regulatory subunit of the type 1 protein phosphatase (PP1) Glc7p physical 4 1 4 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
MNN11 YJL183W Subunit of a Golgi mannosyltransferase complex genetic 4 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
VHS3 YOR054C Negative regulatory subunit of protein phosphatase 1 Ppz1p physical 4 4 3 Affinity Capture-Western, Reconstituted Complex, PCA, Affinity Capture-MS
PKC1 YBL105C Protein serine/threonine kinase genetic 4 3 3 Phenotypic Enhancement, Negative Genetic, Dosage Rescue, Negative Genetic
CAB3 YKL088W Subunit of PPCDC and CoA-SPC complexes involved in CoA biosynthesis physical 4 2 3 Affinity Capture-MS, Affinity Capture-MS, PCA, Affinity Capture-MS
RPA34 YJL148W RNA polymerase I subunit A34.5 genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
IPK1 YDR315C Inositol 1,3,4,5,6-pentakisphosphate 2-kinase genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
CHO2 YGR157W Phosphatidylethanolamine methyltransferase (PEMT) genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
YPI1 YFR003C Regulatory subunit of the type I protein phosphatase (PP1) Glc7p physical 3 3 3 Reconstituted Complex, Two-hybrid, Affinity Capture-MS
GLC7 YER133W Type 1 S/T protein phosphatase (PP1) catalytic subunit genetic 3 2 2 Synthetic Lethality, Synthetic Lethality, Dosage Rescue
TRK1 YJL129C Component of the Trk1p-Trk2p potassium transport system genetic 3 2 2 Synthetic Rescue, Synthetic Growth Defect, Synthetic Rescue
TRK2 YKR050W Component of the Trk1p-Trk2p potassium transport system genetic 3 2 2 Synthetic Rescue, Synthetic Growth Defect, Synthetic Rescue
SLX9 YGR081C Protein required for pre-rRNA processing genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
ACT1 YFL039C Actin, structural protein in cytoskeleton genetic 2 2 2 Synthetic Haploinsufficiency, Negative Genetic
ROM2 YLR371W Guanine nucleotide exchange factor (GEF) for Rho1p and Rho2p genetic 2 2 2 Synthetic Lethality, Negative Genetic
GLN3 YER040W Transcriptional activator in nitrogen catabolite repression system genetic 2 2 2 Phenotypic Suppression, Negative Genetic
ENA1 YDR040C P-type ATPase sodium pump genetic 2 2 2 Synthetic Growth Defect, Dosage Rescue
LSM1 YJL124C Lsm (Like Sm) protein genetic 2 1 2 Negative Genetic, Negative Genetic
PAT1 YCR077C Deadenylation-dependent mRNA-decapping factor genetic 2 1 2 Negative Genetic, Negative Genetic
GCN1 YGL195W Positive regulator of the Gcn2p kinase activity genetic 2 1 2 Negative Genetic, Negative Genetic
LSM7 YNL147W Lsm (Like Sm) protein genetic 2 1 2 Negative Genetic, Negative Genetic
CSE2 YNR010W Subunit of the RNA polymerase II mediator complex genetic 2 1 2 Negative Genetic, Negative Genetic
ARP8 YOR141C Nuclear actin-related protein involved in chromatin remodeling genetic 2 1 2 Negative Genetic, Negative Genetic
ANP1 YEL036C Subunit of the alpha-1,6 mannosyltransferase complex genetic 2 1 2 Negative Genetic, Negative Genetic
PGM1 YKL127W Phosphoglucomutase, minor isoform genetic 2 1 2 Negative Genetic, Negative Genetic
VHS3 YOR054C Negative regulatory subunit of protein phosphatase 1 Ppz1p genetic 2 1 2 Dosage Rescue, Dosage Rescue
PPZ2 YDR436W Serine/threonine protein phosphatase Z, isoform of Ppz1p physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
STE24 YJR117W Highly conserved zinc metalloprotease physical 2 1 2 PCA, PCA
SHP1 YBL058W UBX domain-containing substrate adaptor for Cdc48p physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
SHP1 YBL058W UBX domain-containing substrate adaptor for Cdc48p genetic 2 1 2 Negative Genetic, Negative Genetic
VPS72 YDR485C Htz1p-binding component of the SWR1 complex genetic 2 1 2 Negative Genetic, Negative Genetic
SEC66 YBR171W Non-essential subunit of Sec63 complex genetic 2 1 2 Negative Genetic, Negative Genetic
VMA9 YCL005W-A Vacuolar H+ ATPase subunit e of the V-ATPase V0 subcomplex genetic 2 1 2 Positive Genetic, Positive Genetic
SCC2 YDR180W Subunit of cohesin loading factor (Scc2p-Scc4p) genetic 2 1 2 Negative Genetic, Negative Genetic
SMC1 YFL008W Subunit of the multiprotein cohesin complex genetic 2 1 2 Negative Genetic, Negative Genetic
SMC3 YJL074C Subunit of the multiprotein cohesin complex genetic 2 1 2 Negative Genetic, Negative Genetic
TOR2 YKL203C PIK-related protein kinase and rapamycin target genetic 2 1 2 Negative Genetic, Negative Genetic
SEC13 YLR208W Structural component of 3 complexes genetic 2 1 2 Negative Genetic, Negative Genetic
RAP1 YNL216W Essential DNA-binding transcription regulator that binds many loci genetic 2 1 2 Positive Genetic, Positive Genetic
SHE4 YOR035C Protein containing a UCS (UNC-45/CRO1/SHE4) domain genetic 2 1 2 Negative Genetic, Negative Genetic
SWC5 YBR231C Component of the SWR1 complex genetic 2 1 2 Negative Genetic, Negative Genetic
NUP133 YKR082W Subunit of Nup84p subcomplex of nuclear pore complex (NPC) genetic 2 1 2 Negative Genetic, Negative Genetic
CTK3 YML112W Gamma subunit of C-terminal domain kinase I genetic 2 1 2 Negative Genetic, Negative Genetic
DUO1 YGL061C Essential subunit of the Dam1 complex (aka DASH complex) genetic 2 1 2 Positive Genetic, Positive Genetic
CSM1 YCR086W Nucleolar protein that mediates homolog segregation during meiosis I genetic 2 1 2 Positive Genetic, Positive Genetic
ERG25 YGR060W C-4 methyl sterol oxidase physical 2 1 2 PCA, PCA
LRS4 YDR439W Nucleolar protein that forms a complex with Csm1p genetic 2 1 2 Positive Genetic, Positive Genetic
ERV29 YGR284C Protein localized to COPII-coated vesicles physical 2 1 2 PCA, PCA
PMR1 YGL167C High affinity Ca2+/Mn2+ P-type ATPase genetic 2 1 2 Negative Genetic, Negative Genetic
FPS1 YLL043W Aquaglyceroporin, plasma membrane channel physical 2 1 2 PCA, PCA
ILM1 YJR118C Protein of unknown function genetic 2 1 2 Negative Genetic, Negative Genetic
LSM6 YDR378C Lsm (Like Sm) protein genetic 2 1 1 Negative Genetic, Negative Genetic
GCN20 YFR009W Positive regulator of the Gcn2p kinase activity genetic 2 1 1 Negative Genetic, Negative Genetic
SSB1 YDL229W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 2 1 1 Affinity Capture-MS, Affinity Capture-MS
GEM1 YAL048C Outer mitochondrial membrane GTPase, subunit of the ERMES complex genetic 2 1 1 Negative Genetic, Negative Genetic
FKH1 YIL131C Forkhead family transcription factor regulation 1 1 1 ChEC-Seq experiments
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit regulation 1 1 1 quantitative mass spectrometry evidence
RPS31 YLR167W Fusion protein cleaved to yield ribosomal protein S31 and ubiquitin regulation 1 1 1 qualitative western immunoblotting evidence
NSL1 YPL233W Essential component of the MIND kinetochore complex genetic 1 1 1 Negative Genetic
CKA1 YIL035C Alpha catalytic subunit of casein kinase 2 (CK2) genetic 1 1 1 Positive Genetic
DRS1 YLL008W Nucleolar DEAD-box protein required for ribosome assembly and function genetic 1 1 1 Negative Genetic
NOG1 YPL093W Putative GTPase genetic 1 1 1 Negative Genetic
NOC2 YOR206W Protein involved in ribosome biogenesis genetic 1 1 1 Dosage Rescue
POL5 YEL055C Protein involved in 60S assembly and pre-40S AFs recycling genetic 1 1 1 Negative Genetic
MRT4 YKL009W Protein involved in mRNA turnover and ribosome assembly genetic 1 1 1 Negative Genetic
GUS1 YGL245W Glutamyl-tRNA synthetase (GluRS) genetic 1 1 1 Negative Genetic
NOP56 YLR197W Essential evolutionarily-conserved nucleolar protein genetic 1 1 1 Negative Genetic
PAT1 YCR077C Deadenylation-dependent mRNA-decapping factor physical 1 1 1 Affinity Capture-RNA
LSM3 YLR438C-A Lsm (Like Sm) protein genetic 1 1 1 Negative Genetic
CDC48 YDL126C AAA ATPase with protein-unfoldase activity genetic 1 1 1 Synthetic Growth Defect
MUD1 YBR119W U1 snRNP A protein physical 1 1 1 Two-hybrid
GCD1 YOR260W Gamma subunit of the translation initiation factor eIF2B genetic 1 1 1 Negative Genetic
AAR2 YBL074C Component of the U5 snRNP complex genetic 1 1 1 Positive Genetic
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-RNA
ABD1 YBR236C Methyltransferase genetic 1 1 1 Positive Genetic
ASF1 YJL115W Nucleosome assembly factor genetic 1 1 1 Negative Genetic
BEM1 YBR200W Protein containing SH3-domains genetic 1 1 1 Negative Genetic
ASC1 YMR116C G-protein beta subunit and guanine dissociation inhibitor for Gpa2p physical 1 1 1 Affinity Capture-MS
BUD14 YAR014C Protein involved in bud-site selection genetic 1 1 1 Positive Genetic
CDC11 YJR076C Component of the septin ring that is required for cytokinesis genetic 1 1 1 Negative Genetic
CTF18 YMR078C Subunit of a complex with Ctf8p genetic 1 1 1 Negative Genetic
CTK1 YKL139W Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I) genetic 1 1 1 Negative Genetic
DNA2 YHR164C ATP-dependent 5'-flap endonuclease and DNA helicase genetic 1 1 1 Positive Genetic
EAF3 YPR023C Component of the Rpd3S histone deacetylase complex genetic 1 1 1 Negative Genetic
CCT4 YDL143W Subunit of the cytosolic chaperonin Cct ring complex genetic 1 1 1 Negative Genetic
ERV25 YML012W Member of the p24 family involved in ER to Golgi transport physical 1 1 1 PCA
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
ISW1 YBR245C ATPase subunit of imitation-switch (ISWI) class chromatin remodelers physical 1 1 1 Affinity Capture-RNA
KIN3 YAR018C Nonessential serine/threonine protein kinase genetic 1 1 1 Positive Genetic
LAS17 YOR181W Actin assembly factor physical 1 1 1 Affinity Capture-MS
LAS17 YOR181W Actin assembly factor genetic 1 1 1 Positive Genetic
CRM1 YGR218W Nuclear export factor, exportin physical 1 1 1 Affinity Capture-MS
LST8 YNL006W Protein required for the transport of Gap1p genetic 1 1 1 Negative Genetic
ADA2 YDR448W Transcription coactivator genetic 1 1 1 Negative Genetic
MRPL19 YNL185C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
MRPS16 YPL013C Mitochondrial ribosomal protein of the small subunit genetic 1 1 1 Negative Genetic
MYO2 YOR326W Type V myosin motor involved in actin-based transport of cargos genetic 1 1 1 Negative Genetic
HTZ1 YOL012C Histone variant H2AZ genetic 1 1 1 Negative Genetic
NHP10 YDL002C Non-essential INO80 chromatin remodeling complex subunit genetic 1 1 1 Negative Genetic
GIM5 YML094W Subunit of the heterohexameric cochaperone prefoldin complex genetic 1 1 1 Negative Genetic
HMO1 YDR174W Chromatin associated high mobility group (HMG) family member genetic 1 1 1 Synthetic Growth Defect
HSP82 YPL240C Hsp90 chaperone physical 1 1 1 Affinity Capture-MS
GLE2 YER107C RNA export factor associated with the nuclear pore complex (NPC) genetic 1 1 1 Negative Genetic
HTA1 YDR225W Histone H2A genetic 1 1 1 Positive Genetic
MIR1 YJR077C Mitochondrial phosphate carrier physical 1 1 1 Affinity Capture-MS
IWR1 YDL115C RNA polymerase II transport factor, conserved from yeast to humans genetic 1 1 1 Negative Genetic
PIL1 YGR086C Eisosome core component genetic 1 1 1 Positive Genetic
NUP145 YGL092W Essential protein with distinct roles in two nuclear pore subcomplexes genetic 1 1 1 Negative Genetic
MNN10 YDR245W Subunit of a Golgi mannosyltransferase complex genetic 1 1 1 Negative Genetic
GAL83 YER027C One of three alternate beta-subunits of the Snf1 kinase complex genetic 1 1 1 Positive Genetic
EFB1 YAL003W Translation elongation factor 1 beta physical 1 1 1 Affinity Capture-Western
MKS1 YNL076W Pleiotropic negative transcriptional regulator genetic 1 1 1 Negative Genetic
DRS2 YAL026C Trans-golgi network aminophospholipid translocase (flippase) genetic 1 1 1 Positive Genetic
HEK2 YBL032W RNA binding protein involved in asymmetric localization of ASH1 mRNA physical 1 1 1 Affinity Capture-RNA
DOT6 YER088C Protein involved in rRNA and ribosome biogenesis genetic 1 1 1 Dosage Rescue
GAS1 YMR307W Beta-1,3-glucanosyltransferase required for cell wall assembly genetic 1 1 1 Negative Genetic
LSP1 YPL004C Eisosome core component physical 1 1 1 PCA
HYP2 YEL034W Translation elongation factor eIF-5A genetic 1 1 1 Negative Genetic
PHO85 YPL031C Cyclin-dependent kinase physical 1 1 1 Biochemical Activity
PHO85 YPL031C Cyclin-dependent kinase genetic 1 1 1 Dosage Lethality
HTB1 YDR224C Histone H2B genetic 1 1 1 Positive Genetic
CNB1 YKL190W Calcineurin B genetic 1 1 1 Synthetic Rescue
GLC8 YMR311C Regulatory subunit of protein phosphatase 1 (Glc7p) physical 1 1 1 Two-hybrid
GLC8 YMR311C Regulatory subunit of protein phosphatase 1 (Glc7p) genetic 1 1 1 Synthetic Rescue
PBR1 YNL181W Putative oxidoreductase genetic 1 1 1 Negative Genetic
MRS6 YOR370C Rab escort protein genetic 1 1 1 Positive Genetic
CDC20 YGL116W Activator of anaphase-promoting complex/cyclosome (APC/C) genetic 1 1 1 Positive Genetic
GIP2 YER054C Putative regulatory subunit of protein phosphatase Glc7p physical 1 1 1 Two-hybrid
CDC60 YPL160W Cytosolic leucyl tRNA synthetase genetic 1 1 1 Positive Genetic
MAK11 YKL021C Protein involved in an early step of 60S ribosomal subunit biogenesis genetic 1 1 1 Negative Genetic
NTF2 YER009W Nuclear envelope protein genetic 1 1 1 Negative Genetic
CIN8 YEL061C Bipolar kinesin motor protein genetic 1 1 1 Synthetic Growth Defect
KRI1 YNL308C Essential nucleolar protein required for 40S ribosome biogenesis genetic 1 1 1 Negative Genetic
HOG1 YLR113W Mitogen-activated protein kinase involved in osmoregulation physical 1 1 1 Co-localization
HOG1 YLR113W Mitogen-activated protein kinase involved in osmoregulation genetic 1 1 1 Synthetic Rescue
LHS1 YKL073W Molecular chaperone of the endoplasmic reticulum lumen genetic 1 1 1 Negative Genetic
HAL5 YJL165C Snf1p-related nutrient-responsive protein kinase genetic 1 1 1 Synthetic Rescue
MIH1 YMR036C Protein tyrosine phosphatase genetic 1 1 1 Negative Genetic
ECM33 YBR078W GPI-anchored protein involved in efficient glucose uptake genetic 1 1 1 Negative Genetic
PAP2 YOL115W Non-canonical poly(A) polymerase genetic 1 1 1 Negative Genetic
FKH2 YNL068C Forkhead family transcription factor genetic 1 1 1 Negative Genetic
LSM8 YJR022W Lsm (Like Sm) protein genetic 1 1 1 Negative Genetic
SNU66 YOR308C Component of the U4/U6.U5 snRNP complex physical 1 1 1 Affinity Capture-MS
RED1 YLR263W Protein component of the synaptonemal complex axial elements physical 1 1 1 Two-hybrid
SCD5 YOR329C Protein required for normal actin organization and endocytosis physical 1 1 1 Two-hybrid
SLA1 YBL007C Cytoskeletal protein binding protein physical 1 1 1 Two-hybrid
SLA1 YBL007C Cytoskeletal protein binding protein genetic 1 1 1 Negative Genetic
SPO21 YOL091W Component of the meiotic outer plaque of the spindle pole body physical 1 1 1 Two-hybrid
YTA6 YPL074W Putative ATPase of the CDC48/PAS1/SEC18 (AAA) family physical 1 1 1 Two-hybrid
SMT3 YDR510W Ubiquitin-like protein of the SUMO family physical 1 1 1 Affinity Capture-MS
SNP1 YIL061C Component of U1 snRNP required for mRNA splicing via spliceosome physical 1 1 1 Two-hybrid
TRK1 YJL129C Component of the Trk1p-Trk2p potassium transport system physical 1 1 1 Affinity Capture-Western
RVS167 YDR388W Calmodulin-binding actin-associated protein physical 1 1 1 Affinity Capture-MS
SHR3 YDL212W Endoplasmic reticulum packaging chaperone physical 1 1 1 PCA
PST2 YDR032C FMN-dependent NAD(P)H:quinone oxidoreductase physical 1 1 1 PCA
SUR2 YDR297W Sphinganine C4-hydroxylase physical 1 1 1 PCA
VHS2 YIL135C Regulator of septin dynamics physical 1 1 1 PCA
SFK1 YKL051W Protein that regulates phospholipid asymmetry at plasma membrane physical 1 1 1 PCA
URA5 YML106W Major orotate phosphoribosyltransferase (OPRTase) isozyme physical 1 1 1 PCA
TPO4 YOR273C Polyamine transporter of the major facilitator superfamily physical 1 1 1 PCA
SWP1 YMR149W Delta subunit of the oligosaccharyl transferase glycoprotein complex physical 1 1 1 PCA
PPZ1 YML016C Serine/threonine protein phosphatase Z, isoform of Ppz2p physical 1 1 1 PCA
RAD53 YPL153C DNA damage response kinase physical 1 1 1 Two-hybrid
RAD53 YPL153C DNA damage response kinase genetic 1 1 1 Negative Genetic
ULP2 YIL031W Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins physical 1 1 1 Affinity Capture-MS
VAM6 YDL077C Guanine nucleotide exchange factor for the GTPase Gtr1p physical 1 1 1 Affinity Capture-MS
TOM22 YNL131W Component of the TOM (Translocase of Outer Membrane) complex physical 1 1 1 Affinity Capture-MS
RPS2 YGL123W Protein component of the small (40S) subunit physical 1 1 1 Affinity Capture-MS
RPS10A YOR293W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS12 YOR369C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS17A YML024W Ribosomal protein 51 (rp51) of the small (40s) subunit physical 1 1 1 Affinity Capture-MS
RPS27A YKL156W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS3 YNL178W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
SLG1 YOR008C Sensor-transducer of the stress-activated PKC1-MPK1 kinase pathway genetic 1 1 1 Synthetic Growth Defect
SPC24 YMR117C Component of the kinetochore-associated Ndc80 complex genetic 1 1 1 Synthetic Growth Defect
SIT4 YDL047W Ceramide-activated, type 2A-related serine-threonine phosphatase genetic 1 1 1 Synthetic Rescue
PTC1 YDL006W Type 2C protein phosphatase (PP2C) genetic 1 1 1 Positive Genetic
SNF1 YDR477W AMP-activated S/T protein kinase genetic 1 1 1 Positive Genetic
SNF4 YGL115W Activating gamma subunit of the AMP-activated Snf1p kinase complex genetic 1 1 1 Positive Genetic
SOH1 YGL127C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
SKI8 YGL213C Ski complex component and WD-repeat protein genetic 1 1 1 Positive Genetic
STE20 YHL007C Cdc42p-activated signal transducing kinase genetic 1 1 1 Negative Genetic
THR1 YHR025W Homoserine kinase genetic 1 1 1 Positive Genetic
RPN10 YHR200W Proteasome polyubiquitin receptor genetic 1 1 1 Positive Genetic
SAC1 YKL212W Phosphatidylinositol phosphate phosphatase genetic 1 1 1 Positive Genetic
RIC1 YLR039C Protein involved in retrograde transport to the cis-Golgi network genetic 1 1 1 Positive Genetic
URN1 YPR152C Protein of unknown function containing WW and FF domains genetic 1 1 1 Positive Genetic
YPT10 YBR264C Rab family GTP-binding protein genetic 1 1 1 Negative Genetic
SIN4 YNL236W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Positive Genetic
RTG1 YOL067C Transcription factor (bHLH) involved in interorganelle communication genetic 1 1 1 Positive Genetic
SEC63 YOR254C Essential subunit of Sec63 complex genetic 1 1 1 Negative Genetic
PRP4 YPR178W Splicing factor genetic 1 1 1 Negative Genetic
YKE2 YLR200W Subunit of the heterohexameric Gim/prefoldin protein complex genetic 1 1 1 Synthetic Growth Defect
RAD6 YGL058W Ubiquitin-conjugating enzyme (E2) genetic 1 1 1 Synthetic Growth Defect
SAT4 YCR008W Ser/Thr protein kinase involved in salt tolerance, nutrient response genetic 1 1 1 Synthetic Rescue
SIW14 YNL032W Inositol phosphatase involved in inositol pyrophosphate metabolism genetic 1 1 1 Synthetic Growth Defect
SSN3 YPL042C Component of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
STB4 YMR019W Putative transcription factor genetic 1 1 1 Negative Genetic
PRE9 YGR135W Alpha 3 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
SOK2 YMR016C Nuclear protein that negatively regulates pseudohyphal differentiation genetic 1 1 1 Negative Genetic
SBA1 YKL117W Co-chaperone that binds and regulates Hsp90 family chaperones genetic 1 1 1 Synthetic Lethality
TAF1 YGR274C TFIID subunit, involved in RNA pol II transcription initiation genetic 1 1 1 Synthetic Lethality
SWA2 YDR320C Auxilin-like protein involved in vesicular transport genetic 1 1 1 Negative Genetic
SEC61 YLR378C Conserved ER protein translocation channel genetic 1 1 1 Negative Genetic
PSD1 YNL169C Phosphatidylserine decarboxylase of the mitochondrial inner membrane genetic 1 1 1 Negative Genetic
VPS21 YOR089C Endosomal Rab family GTPase genetic 1 1 1 Negative Genetic
RAD27 YKL113C 5' to 3' exonuclease, 5' flap endonuclease genetic 1 1 1 Positive Genetic
TPM1 YNL079C Major isoform of tropomyosin genetic 1 1 1 Positive Genetic
RER2 YBR002C Forms the dehydrodolichyl diphosphate synthase (DDS) complex with NUS1 genetic 1 1 1 Positive Genetic
TFB1 YDR311W Subunit of TFIIH and nucleotide excision repair factor 3 complexes genetic 1 1 1 Positive Genetic
UTP8 YGR128C Nucleolar protein required for export of tRNAs from the nucleus genetic 1 1 1 Positive Genetic
RPC25 YKL144C RNA polymerase III subunit C25 genetic 1 1 1 Positive Genetic
SEC12 YNR026C Guanine nucleotide exchange factor (GEF) genetic 1 1 1 Positive Genetic
RPT4 YOR259C ATPase of the 19S regulatory particle of the 26S proteasome genetic 1 1 1 Positive Genetic
STB5 YHR178W Transcription factor genetic 1 1 1 Positive Genetic
PRP45 YAL032C Protein required for pre-mRNA splicing genetic 1 1 1 Negative Genetic
STU1 YBL034C Microtubule plus-end-tracking non-motor protein genetic 1 1 1 Negative Genetic
REB1 YBR049C RNA polymerase I enhancer binding protein genetic 1 1 1 Negative Genetic
SEC26 YDR238C Essential beta-coat protein of the COPI coatomer genetic 1 1 1 Negative Genetic
YRA1 YDR381W Nuclear polyadenylated RNA-binding protein genetic 1 1 1 Negative Genetic
SPP41 YDR464W Protein of unknown function genetic 1 1 1 Negative Genetic
RPL28 YGL103W Ribosomal 60S subunit protein L28 genetic 1 1 1 Negative Genetic
SWC4 YGR002C Component of the Swr1p complex that incorporates Htz1p into chromatin genetic 1 1 1 Negative Genetic
URB2 YJR041C Protein required for normal metabolism of the rRNA primary transcript genetic 1 1 1 Negative Genetic
PRP40 YKL012W U1 snRNP protein involved in splicing genetic 1 1 1 Negative Genetic
RPL17A YKL180W Ribosomal 60S subunit protein L17A genetic 1 1 1 Negative Genetic
RPL15A YLR029C Ribosomal 60S subunit protein L15A genetic 1 1 1 Negative Genetic
YHC1 YLR298C Component of the U1 snRNP complex required for pre-mRNA splicing genetic 1 1 1 Negative Genetic
STT4 YLR305C Phosphatidylinositol-4-kinase genetic 1 1 1 Negative Genetic
RPC31 YNL151C RNA polymerase III subunit C31 genetic 1 1 1 Negative Genetic
SWI1 YPL016W Subunit of the SWI/SNF chromatin remodeling complex genetic 1 1 1 Negative Genetic
SEC62 YPL094C Essential subunit of Sec63 complex genetic 1 1 1 Negative Genetic
SUI3 YPL237W Beta subunit of the translation initiation factor eIF2 genetic 1 1 1 Negative Genetic
SGV1 YPR161C Cyclin (Bur2p)-dependent protein kinase genetic 1 1 1 Negative Genetic
RPP1B YDL130W Ribosomal protein P1 beta genetic 1 1 1 Negative Genetic
RPO41 YFL036W Mitochondrial RNA polymerase genetic 1 1 1 Negative Genetic
YGL235W YGL235W Putative protein of unknown function genetic 1 1 1 Negative Genetic
ROF1 YHR177W Putative transcription factor containing a WOPR domain genetic 1 1 1 Negative Genetic
RPL40B YKR094C Ubiquitin-ribosomal 60S subunit protein L40B fusion protein genetic 1 1 1 Negative Genetic
SPT8 YLR055C Subunit of the SAGA transcriptional regulatory complex genetic 1 1 1 Negative Genetic
SND2 YLR065C Protein involved in SRP-independent targeting of substrates to the ER genetic 1 1 1 Negative Genetic
VRP1 YLR337C Verprolin, proline-rich actin-associated protein genetic 1 1 1 Negative Genetic
VPS8 YAL002W Membrane-binding component of the CORVET complex genetic 1 1 1 Negative Genetic
SWC3 YAL011W Protein of unknown function genetic 1 1 1 Negative Genetic
REI1 YBR267W Cytoplasmic pre-60S factor genetic 1 1 1 Negative Genetic
SSH1 YBR283C Subunit of the Ssh1 translocon complex genetic 1 1 1 Negative Genetic
SWR1 YDR334W Swi2/Snf2-related ATPase genetic 1 1 1 Negative Genetic
RPP2B YDR382W Ribosomal protein P2 beta genetic 1 1 1 Negative Genetic
URC2 YDR520C Putative Zn(II)2Cys6 motif containing transcription factor genetic 1 1 1 Negative Genetic
YHB1 YGR234W Nitric oxide oxidoreductase genetic 1 1 1 Negative Genetic
SDS3 YIL084C Component of the Rpd3L histone deacetylase complex genetic 1 1 1 Negative Genetic
SWI6 YLR182W Transcription cofactor genetic 1 1 1 Negative Genetic
UPS1 YLR193C Phosphatidic acid transfer protein genetic 1 1 1 Negative Genetic
SSE1 YPL106C ATPase component of heat shock protein Hsp90 chaperone complex genetic 1 1 1 Negative Genetic
VAC7 YNL054W Integral vacuolar membrane protein genetic 1 1 1 Negative Genetic
RPA49 YNL248C RNA polymerase I subunit A49 genetic 1 1 1 Negative Genetic
RPL18B YNL301C Ribosomal 60S subunit protein L18B genetic 1 1 1 Negative Genetic
RGL1 YPL066W Regulator of Rho1p signaling, cofactor of Tus1p genetic 1 1 1 Negative Genetic
UBI4 YLL039C Ubiquitin genetic 1 1 1 Synthetic Rescue
RPS6A YPL090C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Dosage Rescue
RPS15 YOL040C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Dosage Rescue
RPL37A YLR185W Ribosomal 60S subunit protein L37A genetic 1 1 1 Dosage Rescue
RPL37B YDR500C Ribosomal 60S subunit protein L37B genetic 1 1 1 Dosage Rescue
RPP2A YOL039W Ribosomal protein P2 alpha genetic 1 1 1 Dosage Rescue
SPO20 YMR017W Meiosis-specific subunit of the t-SNARE complex genetic 1 1 1 Dosage Rescue
SWM1 YDR260C Subunit of the anaphase-promoting complex (APC) genetic 1 1 1 Dosage Rescue
SKO1 YNL167C Basic leucine zipper transcription factor of the ATF/CREB family genetic 1 1 1 Synthetic Growth Defect
BUB3 YOR026W Kinetochore checkpoint WD40 repeat protein genetic 1 1 1 Synthetic Lethality
CKI1 YLR133W Choline kinase genetic 1 1 1 Negative Genetic
CDC7 YDL017W S/T kinase and catalytic subunit of DDK (Dbf4-dependent kinase) genetic 1 1 1 Synthetic Growth Defect
ERG11 YHR007C Lanosterol 14-alpha-demethylase physical 1 1 1 PCA
NBP2 YDR162C Protein involved in the HOG (high osmolarity glycerol) pathway genetic 1 1 1 Positive Genetic
PEX29 YDR479C ER-resident protein involved in peroxisomal biogenesis genetic 1 1 1 Negative Genetic
BUD27 YFL023W Unconventional prefoldin protein involved in translation initiation genetic 1 1 1 Negative Genetic
MOB2 YFL034C-B Activator of Cbk1p kinase genetic 1 1 1 Positive Genetic
CHA4 YLR098C DNA binding transcriptional activator genetic 1 1 1 Negative Genetic
KEG1 YFR042W Integral membrane protein of the ER genetic 1 1 1 Negative Genetic
AIM4 YBR194W Protein proposed to be associated with the nuclear pore complex genetic 1 1 1 Negative Genetic
APC5 YOR249C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 1 1 1 Positive Genetic
PEX13 YLR191W Peroxisomal importomer complex component genetic 1 1 1 Negative Genetic
ARP6 YLR085C Actin-related protein that binds nucleosomes genetic 1 1 1 Negative Genetic
IES3 YLR052W Subunit of the INO80 chromatin remodeling complex genetic 1 1 1 Negative Genetic
CPT1 YNL130C Cholinephosphotransferase physical 1 1 1 PCA
DBF4 YDR052C Regulatory subunit of Cdc7p-Dbf4p kinase complex genetic 1 1 1 Negative Genetic
MCM3 YEL032W Protein involved in DNA replication genetic 1 1 1 Positive Genetic
MEX67 YPL169C Poly(A)RNA binding protein involved in nuclear mRNA export genetic 1 1 1 Negative Genetic
MTR2 YKL186C mRNA transport regulator genetic 1 1 1 Negative Genetic
OST2 YOR103C Epsilon subunit of the oligosaccharyltransferase complex genetic 1 1 1 Negative Genetic
PHO80 YOL001W Cyclin genetic 1 1 1 Positive Genetic
PAM18 YLR008C Subunit of the import motor (PAM complex) genetic 1 1 1 Negative Genetic
PEP7 YDR323C Adaptor protein involved in vesicle-mediated vacuolar protein sorting genetic 1 1 1 Negative Genetic
MPT5 YGL178W mRNA-binding protein of the PUF family genetic 1 1 1 Negative Genetic
FBP1 YLR377C Fructose-1,6-bisphosphatase physical 1 1 1 Affinity Capture-MS
MID2 YLR332W O-glycosylated plasma membrane protein physical 1 1 1 PCA
MID2 YLR332W O-glycosylated plasma membrane protein genetic 1 1 1 Synthetic Growth Defect
ADY4 YLR227C Structural component of the meiotic outer plaque genetic 1 1 1 Negative Genetic
PFY1 YOR122C Profilin genetic 1 1 1 Negative Genetic
CHS5 YLR330W Component of the exomer complex genetic 1 1 1 Synthetic Rescue
DBP6 YNR038W Essential protein involved in ribosome biogenesis genetic 1 1 1 Negative Genetic
MON2 YNL297C Protein with a role in endocytosis and vacuole integrity genetic 1 1 1 Negative Genetic
PDR12 YPL058C Plasma membrane ATP-binding cassette (ABC) transporter physical 1 1 1 PCA
NOP8 YOL144W Nucleolar protein required for 60S ribosomal subunit biogenesis genetic 1 1 1 Negative Genetic
IXR1 YKL032C Transcriptional repressor that regulates hypoxic genes during normoxia genetic 1 1 1 Negative Genetic
HNM1 YGL077C Plasma membrane transporter for choline, ethanolamine, and carnitine physical 1 1 1 PCA
ERI1 YPL096C-A Endoplasmic reticulum membrane protein that binds and inhibits Ras2p genetic 1 1 1 Negative Genetic
EHT1 YBR177C Octanoyl-CoA:ethanol acyltransferase physical 1 1 1 PCA
KCS1 YDR017C Inositol hexakisphosphate and inositol heptakisphosphate kinase genetic 1 1 1 Negative Genetic
JIP4 YDR475C Protein of unknown function physical 1 1 1 Affinity Capture-MS
PLM2 YDR501W Putative transcription factor, contains Forkhead Associated domain physical 1 1 1 PCA
PPT1 YGR123C Protein serine/threonine phosphatase genetic 1 1 1 Negative Genetic
IMP21 YIL154C Transcriptional activator involved in maintenance of ion homeostasis physical 1 1 1 Affinity Capture-MS
NOP19 YGR251W Ribosome biogenesis factor genetic 1 1 1 Negative Genetic
GRE3 YHR104W Aldose reductase genetic 1 1 1 Positive Genetic
MEF2 YJL102W Mitochondrial elongation factor involved in translational elongation genetic 1 1 1 Negative Genetic
OLE1 YGL055W Delta(9) fatty acid desaturase physical 1 1 1 PCA
MDM36 YPR083W Mitochondrial protein genetic 1 1 1 Negative Genetic
ADE12 YNL220W Adenylosuccinate synthase genetic 1 1 1 Negative Genetic
GLN4 YOR168W Glutamine tRNA synthetase genetic 1 1 1 Negative Genetic
MRPL32 YCR003W Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
NHA1 YLR138W Na+/H+ antiporter physical 1 1 1 PCA
HUR1 YGL168W Protein with a role in DNA repair genetic 1 1 1 Negative Genetic
DER1 YBR201W ER membrane protein that promotes export of misfolded polypeptides genetic 1 1 1 Negative Genetic
NCB2 YDR397C Subunit of a heterodimeric NC2 transcription regulator complex genetic 1 1 1 Negative Genetic
MUP1 YGR055W High affinity methionine permease physical 1 1 1 PCA
HSP30 YCR021C Negative regulator of the H(+)-ATPase Pma1p physical 1 1 1 PCA
PIS1 YPR113W Phosphatidylinositol synthase physical 1 1 1 PCA
MEP3 YPR138C Ammonium permease of high capacity and low affinity physical 1 1 1 PCA
FLC1 YPL221W Flavin adenine dinucleotide transporter physical 1 1 1 PCA
COS7 YDL248W Endosomal protein involved in turnover of plasma membrane proteins genetic 1 1 1 Negative Genetic
DYN3 YMR299C Dynein light intermediate chain (LIC) genetic 1 1 1 Negative Genetic
EFR3 YMR212C Protein required for Stt4-containing PI kinase complex localization physical 1 1 1 PCA
HAL1 YPR005C Cytoplasmic protein involved in halotolerance physical 1 1 1 Affinity Capture-MS
MRM2 YGL136C Mitochondrial 2' O-ribose methyltransferase genetic 1 1 1 Positive Genetic
CRD1 YDL142C Cardiolipin synthase genetic 1 1 1 Negative Genetic
MGR2 YPL098C Subunit of the TIM23 translocase complex genetic 1 1 1 Negative Genetic
ICE2 YIL090W Integral ER membrane protein with type-III transmembrane domains genetic 1 1 1 Positive Genetic
ADF1 YCL058W-A Transcriptional repressor encoded by the FYV5 antisense strand genetic 1 1 1 Negative Genetic
OCA6 YDR067C Cytoplasmic protein required for replication of Brome mosaic virus genetic 1 1 1 Positive Genetic