Standard name Systematic name Name description Description
PIS1 YPR113W Phosphatidylinositol synthase Phosphatidylinositol synthase; required for biosynthesis of phosphatidylinositol, which is a precursor for polyphosphoinositides, sphingolipids, and glycolipid anchors for some of the plasma membrane proteins
Visualize the interactome of PIS1
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.597 0.596 0.443
ER 0.420 0.452 0.552
Cort. Patches NaN NaN 0.061

GFP localization & abundance

GFP localization GFP abundance
ER 3810

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
PIS1 2 0 0 0 0

Enzyme information

Catalyzed reactions in Yeast8
r_2458 (PI synthase (1-16:0, 2-18:1), ER membrane), r_2455 (PI synthase (1-16:1, 2-16:1), ER membrane), r_2461 (PI synthase (1-18:1, 2-18:1), ER membrane), r_2454 (PI synthase (1-16:0, 2-16:1), ER membrane), r_2457 (PI synthase (1-18:1, 2-16:1), ER membrane), r_2460 (PI synthase (1-18:0, 2-18:1), ER membrane), r_2459 (PI synthase (1-16:1, 2-18:1), ER membrane), r_2456 (PI synthase (1-18:0, 2-16:1), ER membrane)

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
GCR1 YPL075W Transcriptional activator of genes involved in glycolysis regulation 3 3 1 beta-galactosidase reporter gene assay evidence, electrophoretic mobility shift assay evidence, quantitative reverse transcription polymerase chain reaction evidence
MPS3 YJL019W Nuclear envelope protein physical 2 2 2 Two-hybrid, Affinity Capture-MS
MPT5 YGL178W mRNA-binding protein of the PUF family physical 2 1 2 Affinity Capture-RNA, Affinity Capture-RNA
PIS1 YPR113W Phosphatidylinositol synthase physical 2 1 2 PCA, PCA
SSA1 YAL005C ATPase involved in protein folding and NLS-directed nuclear transport physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
GAP1 YKR039W General amino acid permease physical 2 2 1 Two-hybrid, Affinity Capture-Western
FKH1 YIL131C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
FKH2 YNL068C Forkhead family transcription factor regulation 1 1 1 ChEC-Seq experiments
XBP1 YIL101C Transcriptional repressor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
YAP6 YDR259C Basic leucine zipper (bZIP) transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
ZAP1 YJL056C Zinc-regulated transcription factor regulation 1 1 1 DNA to cDNA expression microarray evidence
MCM1 YMR043W Transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CAB3 YKL088W Subunit of PPCDC and CoA-SPC complexes involved in CoA biosynthesis physical 1 1 1 PCA
PAT1 YCR077C Deadenylation-dependent mRNA-decapping factor physical 1 1 1 Affinity Capture-RNA
DED1 YOR204W ATP-dependent DEAD-box RNA helicase with strand-annealing activity physical 1 1 1 Affinity Capture-MS
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-RNA
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit genetic 1 1 1 Dosage Rescue
ERP1 YAR002C-A Member of the p24 family involved in ER to Golgi transport physical 1 1 1 PCA
ERV25 YML012W Member of the p24 family involved in ER to Golgi transport physical 1 1 1 PCA
AYR1 YIL124W Bifunctional triacylglycerol lipase and 1-acyl DHAP reductase physical 1 1 1 PCA
HOM6 YJR139C Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase) genetic 1 1 1 Negative Genetic
CYS3 YAL012W Cystathionine gamma-lyase genetic 1 1 1 Negative Genetic
ERG11 YHR007C Lanosterol 14-alpha-demethylase physical 1 1 1 PCA
PEX29 YDR479C ER-resident protein involved in peroxisomal biogenesis physical 1 1 1 Two-hybrid
NDC1 YML031W Subunit of the transmembrane ring of the nuclear pore complex (NPC) physical 1 1 1 PCA
LAM6 YLR072W Sterol transporter that transfers sterols between membranes physical 1 1 1 Two-hybrid
BFR1 YOR198C Component of mRNP complexes associated with polyribosomes physical 1 1 1 Affinity Capture-RNA
MST28 YAR033W Putative integral membrane protein, involved in vesicle formation physical 1 1 1 Two-hybrid
EMC5 YIL027C Member of conserved ER transmembrane complex physical 1 1 1 PCA
NCP1 YHR042W NADP-cytochrome P450 reductase physical 1 1 1 PCA
GTT1 YIR038C ER associated glutathione S-transferase physical 1 1 1 Two-hybrid
ERG5 YMR015C C-22 sterol desaturase physical 1 1 1 PCA
BTS1 YPL069C Geranylgeranyl diphosphate synthase (GGPPS) genetic 1 1 1 Positive Genetic
ERG2 YMR202W C-8 sterol isomerase genetic 1 1 1 Positive Genetic
MSC7 YHR039C Protein of unknown function physical 1 1 1 PCA
GCS1 YDL226C ADP-ribosylation factor GTPase activating protein (ARF GAP) physical 1 1 1 Two-hybrid
APJ1 YNL077W Hsp40 chaperone with a role in SUMO-mediated protein degradation physical 1 1 1 Affinity Capture-MS
CDC50 YCR094W Endosomal protein that interacts with phospholipid flippase Drs2p genetic 1 1 1 Synthetic Rescue
OSH6 YKR003W Oxysterol-binding phosphatidylserine transferase physical 1 1 1 PCA
RER2 YBR002C Forms the dehydrodolichyl diphosphate synthase (DDS) complex with NUS1 physical 1 1 1 PCA
SND3 YBR106W Involved in SRP-independent protein targeting to the ER physical 1 1 1 PCA
SSH1 YBR283C Subunit of the Ssh1 translocon complex physical 1 1 1 PCA
SHR3 YDL212W Endoplasmic reticulum packaging chaperone physical 1 1 1 PCA
TMS1 YDR105C Vacuolar membrane protein of unknown function physical 1 1 1 PCA
SIS2 YKR072C Negative regulatory subunit of protein phosphatase 1 (Ppz1p) physical 1 1 1 PCA
PPZ1 YML016C Serine/threonine protein phosphatase Z, isoform of Ppz2p physical 1 1 1 PCA
TCB3 YML072C Cortical ER protein involved in ER-plasma membrane tethering physical 1 1 1 PCA
ROD1 YOR018W Alpha-arrestin involved in ubiquitin-dependent endocytosis physical 1 1 1 PCA
SEY1 YOR165W Dynamin-like GTPase that mediates homotypic ER fusion physical 1 1 1 PCA
TAE1 YBR261C AdoMet-dependent proline methyltransferase physical 1 1 1 Two-hybrid
SEC14 YMR079W Phosphatidylinositol/phosphatidylcholine transfer protein physical 1 1 1 Two-hybrid
UIP3 YAR027W Putative integral membrane protein of unknown function physical 1 1 1 Two-hybrid
USA1 YML029W Scaffold subunit of the Hrd1p ubiquitin ligase physical 1 1 1 Two-hybrid
SRO9 YCL037C Cytoplasmic RNA-binding protein physical 1 1 1 Affinity Capture-RNA
SSA2 YLL024C HSP70 family ATP-binding protein physical 1 1 1 Affinity Capture-MS
VMA1 YDL185W Subunit A of the V1 peripheral membrane domain of V-ATPase physical 1 1 1 Affinity Capture-MS
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
RSP5 YER125W NEDD4 family E3 ubiquitin ligase genetic 1 1 1 Dosage Rescue
TPS2 YDR074W Phosphatase subunit of the trehalose-6-P synthase/phosphatase complex genetic 1 1 1 Negative Genetic
SPE1 YKL184W Ornithine decarboxylase genetic 1 1 1 Negative Genetic
TAM41 YGR046W Mitochondrial phosphatidate cytidylyltransferase (CDP-DAG synthase) genetic 1 1 1 Dosage Lethality
MET22 YOL064C Bisphosphate-3'-nucleotidase genetic 1 1 1 Negative Genetic