| ICE2 |
YIL090W |
Integral ER membrane protein with type-III transmembrane domains |
genetic |
8 |
1 |
6 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| YOP1 |
YPR028W |
Reticulon-interacting protein |
genetic |
7 |
2 |
6 |
Negative Genetic, Negative Genetic, Phenotypic Enhancement, Negative Genetic, Phenotypic Enhancement, Negative Genetic, Negative Genetic |
| SCS3 |
YGL126W |
Protein required for normal ER membrane biosynthesis in response to ER |
genetic |
7 |
1 |
5 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| USE1 |
YGL098W |
Essential SNARE protein localized to the ER |
genetic |
5 |
3 |
4 |
Negative Genetic, Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Growth Defect, Negative Genetic |
| NUM1 |
YDR150W |
Protein required for nuclear migration |
genetic |
5 |
1 |
4 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| POM33 |
YLL023C |
Transmembrane nucleoporin |
genetic |
5 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| ARP1 |
YHR129C |
Actin-related protein of the dynactin complex |
genetic |
4 |
1 |
4 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| SEC20 |
YDR498C |
Membrane glycoprotein v-SNARE |
genetic |
4 |
3 |
3 |
Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Growth Defect, Negative Genetic |
| GET2 |
YER083C |
Subunit of the GET complex |
genetic |
4 |
2 |
3 |
Positive Genetic, Positive Genetic, Positive Genetic, Negative Genetic |
| UFE1 |
YOR075W |
t-SNARE protein required for retrograde vesicular traffic |
genetic |
4 |
2 |
3 |
Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect |
| DGK1 |
YOR311C |
Diacylglycerol kinase |
genetic |
4 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| OPI3 |
YJR073C |
Methylene-fatty-acyl-phospholipid synthase |
genetic |
4 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| JNM1 |
YMR294W |
Component of the yeast dynactin complex |
genetic |
3 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic |
| NIP100 |
YPL174C |
Large subunit of the dynactin complex |
genetic |
3 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic |
| SLY1 |
YDR189W |
Hydrophilic protein involved in ER/Golgi vesicle trafficking |
genetic |
3 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic |
| UBP3 |
YER151C |
Ubiquitin-specific protease that cleaves Ub-protein fusions |
genetic |
3 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic |
| TIP20 |
YGL145W |
Peripheral membrane protein required for COPI vesicle fusion to the ER |
genetic |
3 |
3 |
2 |
Synthetic Growth Defect, Phenotypic Enhancement, Negative Genetic |
| BRE5 |
YNR051C |
Ubiquitin protease cofactor |
genetic |
3 |
2 |
2 |
Phenotypic Enhancement, Phenotypic Enhancement, Negative Genetic |
| SEC22 |
YLR268W |
R-SNARE protein |
genetic |
3 |
2 |
2 |
Phenotypic Enhancement, Phenotypic Suppression, Phenotypic Enhancement |
| HAC1 |
YFL031W |
Basic leucine zipper (bZIP) transcription factor (ATF/CREB1 homolog) |
genetic |
3 |
2 |
2 |
Positive Genetic, Positive Genetic, Negative Genetic |
| RTN1 |
YDR233C |
Reticulon protein |
genetic |
3 |
2 |
2 |
Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Enhancement |
| PGA3 |
YML125C |
Putative cytochrome b5 reductase, localized to the plasma membrane |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| DSL1 |
YNL258C |
Peripheral membrane protein needed for Golgi-to-ER retrograde traffic |
genetic |
3 |
3 |
1 |
Synthetic Growth Defect, Phenotypic Enhancement, Negative Genetic |
| ESS1 |
YJR017C |
Peptidylprolyl-cis/trans-isomerase (PPIase) |
genetic |
2 |
2 |
2 |
Synthetic Rescue, Negative Genetic |
| SEC39 |
YLR440C |
Component of the Dsl1p tethering complex |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Negative Genetic |
| SEY1 |
YOR165W |
Dynamin-like GTPase that mediates homotypic ER fusion |
physical |
2 |
2 |
2 |
PCA, Affinity Capture-MS |
| YKT6 |
YKL196C |
Vesicle membrane protein (v-SNARE) with acyltransferase activity |
genetic |
2 |
2 |
2 |
Phenotypic Enhancement, Positive Genetic |
| DHH1 |
YDL160C |
Cytoplasmic DEAD-box helicase and mRNA decapping activator |
physical |
2 |
1 |
2 |
Affinity Capture-RNA, Affinity Capture-RNA |
| HTA1 |
YDR225W |
Histone H2A |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| SEC23 |
YPR181C |
GTPase-activating protein, stimulates the GTPase activity of Sar1p |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| GOT1 |
YMR292W |
Homodimeric protein that is packaged into COPII vesicles |
physical |
2 |
1 |
2 |
PCA, PCA |
| LNP1 |
YHR192W |
Lunapark family member involved in ER network formation |
genetic |
2 |
1 |
2 |
Phenotypic Suppression, Phenotypic Suppression |
| MDM34 |
YGL219C |
Mitochondrial component of the ERMES complex |
genetic |
2 |
2 |
1 |
Synthetic Growth Defect, Phenotypic Enhancement |
| RIC1 |
YLR039C |
Protein involved in retrograde transport to the cis-Golgi network |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| ERP1 |
YAR002C-A |
Member of the p24 family involved in ER to Golgi transport |
genetic |
2 |
1 |
1 |
Phenotypic Enhancement, Phenotypic Enhancement |
| INO4 |
YOL108C |
Transcription factor involved in phospholipid synthesis |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| PMA1 |
YGL008C |
Plasma membrane P2-type H+-ATPase |
genetic |
2 |
1 |
1 |
Positive Genetic, Positive Genetic |
| YOP1 |
YPR028W |
Reticulon-interacting protein |
physical |
2 |
1 |
1 |
Affinity Capture-Western, Affinity Capture-Western |
| TSC3 |
YBR058C-A |
Protein that stimulates the activity of serine palmitoyltransferase |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| TRS20 |
YBR254C |
Core component of transport protein particle (TRAPP) complexes I-III |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| ZAP1 |
YJL056C |
Zinc-regulated transcription factor |
genetic |
2 |
1 |
1 |
Phenotypic Suppression, Phenotypic Suppression |
| VPH2 |
YKL119C |
Integral membrane protein required for V-ATPase function |
genetic |
2 |
1 |
1 |
Positive Genetic, Positive Genetic |
| YME1 |
YPR024W |
Catalytic subunit of i-AAA protease complex |
genetic |
2 |
1 |
1 |
Positive Genetic, Positive Genetic |
| SRC1 |
YML034W |
Inner nuclear membrane protein |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| SED4 |
YCR067C |
Integral ER membrane protein that stimulates Sar1p GTPase activity |
genetic |
2 |
1 |
1 |
Phenotypic Enhancement, Phenotypic Enhancement |
| ERD1 |
YDR414C |
Predicted membrane protein required for lumenal ER protein retention |
genetic |
2 |
1 |
1 |
Phenotypic Suppression, Phenotypic Suppression |
| KEI1 |
YDR367W |
Component of inositol phosphorylceramide (IPC) synthase |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| FKH1 |
YIL131C |
Forkhead family transcription factor |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| MED2 |
YDL005C |
Subunit of the RNA polymerase II mediator complex |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| POB3 |
YML069W |
Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ARP4 |
YJL081C |
Nuclear actin-related protein involved in chromatin remodeling |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MFT1 |
YML062C |
Subunit of the THO complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPN1 |
YHR027C |
Non-ATPase base subunit of the 19S RP of the 26S proteasome |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPN6 |
YDL097C |
Essential, non-ATPase regulatory subunit of the 26S proteasome lid |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CYS4 |
YGR155W |
Cystathionine beta-synthase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ERP1 |
YAR002C-A |
Member of the p24 family involved in ER to Golgi transport |
physical |
1 |
1 |
1 |
PCA |
| ERV25 |
YML012W |
Member of the p24 family involved in ER to Golgi transport |
physical |
1 |
1 |
1 |
PCA |
| ESP1 |
YGR098C |
Separase/separin, a caspase-like cysteine protease |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| ISW1 |
YBR245C |
ATPase subunit of imitation-switch (ISWI) class chromatin remodelers |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| HSL1 |
YKL101W |
Nim1p-related protein kinase |
genetic |
1 |
1 |
1 |
Positive Genetic |
| OST1 |
YJL002C |
Alpha subunit of the oligosaccharyltransferase complex of the ER lumen |
genetic |
1 |
1 |
1 |
Negative Genetic |
| LPD1 |
YFL018C |
Dihydrolipoamide dehydrogenase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PDA1 |
YER178W |
E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| PIM1 |
YBL022C |
ATP-dependent Lon protease |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NAB3 |
YPL190C |
RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPD3 |
YNL330C |
Histone deacetylase, component of both the Rpd3S and Rpd3L complexes |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| OPI1 |
YHL020C |
Transcriptional regulator of a variety of genes |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SCS2 |
YER120W |
Integral ER membrane protein, regulates phospholipid metabolism |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| NUP120 |
YKL057C |
Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| NUP84 |
YDL116W |
Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| NUP85 |
YJR042W |
Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| SEN1 |
YLR430W |
ATP-dependent 5' to 3' RNA/DNA and DNA helicase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CAB5 |
YDR196C |
Subunit of the CoA-Synthesizing Protein Complex (CoA-SPC) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| GET1 |
YGL020C |
Subunit of the GET complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CCT3 |
YJL014W |
Subunit of the cytosolic chaperonin Cct ring complex |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| HHT1 |
YBR010W |
Histone H3 |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ERG11 |
YHR007C |
Lanosterol 14-alpha-demethylase |
physical |
1 |
1 |
1 |
PCA |
| NUP133 |
YKR082W |
Subunit of Nup84p subcomplex of nuclear pore complex (NPC) |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| DAD1 |
YDR016C |
Essential subunit of the Dam1 complex (aka DASH complex) |
genetic |
1 |
1 |
1 |
Positive Genetic |
| INO2 |
YDR123C |
Transcription factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| IRE1 |
YHR079C |
Serine-threonine kinase and endoribonuclease |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MSN5 |
YDR335W |
Karyopherin |
genetic |
1 |
1 |
1 |
Positive Genetic |
| NDC1 |
YML031W |
Subunit of the transmembrane ring of the nuclear pore complex (NPC) |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| AIM7 |
YDR063W |
Protein that interacts with Arp2/3 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| BOS1 |
YLR078C |
v-SNARE (vesicle specific SNAP receptor) |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| CEP3 |
YMR168C |
Essential kinetochore protein |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SAC3 |
YDR159W |
mRNA export factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PHO80 |
YOL001W |
Cyclin |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RAD5 |
YLR032W |
DNA helicase/Ubiquitin ligase |
genetic |
1 |
1 |
1 |
Dosage Lethality |
| SEC22 |
YLR268W |
R-SNARE protein |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
| KAR2 |
YJL034W |
ATPase involved in protein import into the ER |
genetic |
1 |
1 |
1 |
Positive Genetic |
| HAP4 |
YKL109W |
Transcription factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CSG2 |
YBR036C |
Endoplasmic reticulum membrane protein |
genetic |
1 |
1 |
1 |
Positive Genetic |
| PEX30 |
YLR324W |
ER-resident protein involved in peroxisomal biogenesis |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| ERV29 |
YGR284C |
Protein localized to COPII-coated vesicles |
physical |
1 |
1 |
1 |
PCA |
| PER33 |
YLR064W |
Protein that localizes to the endoplasmic reticulum |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
| PER33 |
YLR064W |
Protein that localizes to the endoplasmic reticulum |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| RTN1 |
YDR233C |
Reticulon protein |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| CBS1 |
YDL069C |
Mitochondrial translational activator of the COB mRNA |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RGL1 |
YPL066W |
Regulator of Rho1p signaling, cofactor of Tus1p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| POM33 |
YLL023C |
Transmembrane nucleoporin |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
| AST1 |
YBL069W |
Lipid raft associated protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PGA2 |
YNL149C |
Essential protein required for maturation of Gas1p and Pho8p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| LDB18 |
YLL049W |
Component of the dynactin complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PIS1 |
YPR113W |
Phosphatidylinositol synthase |
physical |
1 |
1 |
1 |
PCA |
| SND3 |
YBR106W |
Involved in SRP-independent protein targeting to the ER |
physical |
1 |
1 |
1 |
PCA |
| SSB2 |
YNL209W |
Cytoplasmic ATPase that is a ribosome-associated molecular chaperone |
physical |
1 |
1 |
1 |
Co-purification |
| UFE1 |
YOR075W |
t-SNARE protein required for retrograde vesicular traffic |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
| SLA1 |
YBL007C |
Cytoskeletal protein binding protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SPF1 |
YEL031W |
P-type ATPase, ion transporter of the ER membrane |
genetic |
1 |
1 |
1 |
Negative Genetic |
| VPS54 |
YDR027C |
Component of the GARP (Golgi-associated retrograde protein) complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| YJR120W |
YJR120W |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SSD1 |
YDR293C |
Translational repressor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SFB3 |
YHR098C |
Component of the Sec23p-Sfb3p heterodimer of the COPII vesicle coat |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SLA2 |
YNL243W |
Adaptor protein that links actin to clathrin and endocytosis |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YBP1 |
YBR216C |
Protein involved in cellular response to oxidative stress |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SIZ1 |
YDR409W |
SUMO E3 ligase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YPS1 |
YLR120C |
Aspartic protease |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SSF1 |
YHR066W |
Constituent of 66S pre-ribosomal particles |
genetic |
1 |
1 |
1 |
Positive Genetic |
| VPS51 |
YKR020W |
Component of the GARP (Golgi-associated retrograde protein) complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| CEM1 |
YER061C |
Mitochondrial beta-keto-acyl synthase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DYN3 |
YMR299C |
Dynein light intermediate chain (LIC) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| AVL9 |
YLR114C |
Conserved protein involved in exocytic transport from the Golgi |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ISC1 |
YER019W |
Inositol phosphosphingolipid phospholipase C |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CMC1 |
YKL137W |
Copper-binding protein of the mitochondrial intermembrane space |
genetic |
1 |
1 |
1 |
Negative Genetic |
| EMC3 |
YKL207W |
Member of conserved ER transmembrane complex |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| LNP1 |
YHR192W |
Lunapark family member involved in ER network formation |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
| PAU12 |
YGR294W |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
