NUP84 |
YDL116W |
Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) |
physical |
13 |
5 |
9 |
Affinity Capture-MS, Co-purification, Affinity Capture-MS, Affinity Capture-MS, Reconstituted Complex, Two-hybrid, Affinity Capture-Western, Two-hybrid, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS |
RAD27 |
YKL113C |
5' to 3' exonuclease, 5' flap endonuclease |
genetic |
9 |
2 |
7 |
Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Lethality, Negative Genetic |
RAD52 |
YML032C |
Protein involved in homologous recombination |
genetic |
8 |
3 |
7 |
Synthetic Lethality, Negative Genetic, Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Synthetic Lethality, Negative Genetic |
MRE11 |
YMR224C |
Nuclease subunit of the MRX complex with Rad50p and Xrs2p |
genetic |
7 |
2 |
6 |
Synthetic Lethality, Negative Genetic, Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Lethality, Negative Genetic |
POM34 |
YLR018C |
Subunit of the transmembrane ring of the nuclear pore complex (NPC) |
genetic |
7 |
2 |
5 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Lethality |
RAD51 |
YER095W |
Strand exchange protein |
genetic |
6 |
3 |
6 |
Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Synthetic Lethality, Negative Genetic, Negative Genetic |
RAD50 |
YNL250W |
Subunit of MRX complex with Mre11p and Xrs2p |
genetic |
6 |
2 |
6 |
Synthetic Lethality, Negative Genetic, Synthetic Lethality, Negative Genetic, Synthetic Lethality, Negative Genetic |
NUP60 |
YAR002W |
FG-nucleoporin component of central core of the nuclear pore complex |
genetic |
6 |
2 |
5 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
MRC1 |
YCL061C |
S-phase checkpoint protein required for DNA replication |
genetic |
6 |
2 |
5 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Lethality, Negative Genetic |
NUP188 |
YML103C |
Subunit of the inner ring of the nuclear pore complex (NPC) |
genetic |
6 |
2 |
4 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
POM152 |
YMR129W |
Glycoprotein subunit of transmembrane ring of nuclear pore complex |
genetic |
6 |
2 |
4 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
PML39 |
YML107C |
Protein required for nuclear retention of unspliced pre-mRNAs |
genetic |
6 |
2 |
4 |
Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
MAD1 |
YGL086W |
Coiled-coil protein involved in spindle-assembly checkpoint |
genetic |
6 |
2 |
4 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
LSM1 |
YJL124C |
Lsm (Like Sm) protein |
genetic |
6 |
1 |
4 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
RCO1 |
YMR075W |
Essential component of the Rpd3S histone deacetylase complex |
genetic |
6 |
1 |
4 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
NUP120 |
YKL057C |
Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) |
physical |
5 |
3 |
4 |
Affinity Capture-MS, Affinity Capture-MS, Reconstituted Complex, Affinity Capture-MS, Affinity Capture-Western |
NUP170 |
YBL079W |
Subunit of inner ring of nuclear pore complex (NPC) |
genetic |
5 |
3 |
4 |
Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic |
RAD57 |
YDR004W |
Protein that stimulates strand exchange |
genetic |
5 |
2 |
4 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
POM33 |
YLL023C |
Transmembrane nucleoporin |
genetic |
5 |
2 |
4 |
Synthetic Growth Defect, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic |
NUP100 |
YKL068W |
FG-nucleoporin component of central core of the nuclear pore complex |
physical |
5 |
2 |
4 |
Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Reconstituted Complex |
CHS5 |
YLR330W |
Component of the exomer complex |
genetic |
5 |
2 |
4 |
Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic |
CKB2 |
YOR039W |
Beta' regulatory subunit of casein kinase 2 (CK2) |
genetic |
5 |
2 |
3 |
Phenotypic Enhancement, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
ARX1 |
YDR101C |
Nuclear export factor for the ribosomal pre-60S subunit |
genetic |
5 |
2 |
3 |
Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
NUP42 |
YDR192C |
FG-nucleoporin component of central core of the nuclear pore complex |
genetic |
5 |
2 |
3 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
NUP85 |
YJR042W |
Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) |
physical |
5 |
2 |
3 |
Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western |
NUP145 |
YGL092W |
Essential protein with distinct roles in two nuclear pore subcomplexes |
physical |
5 |
2 |
3 |
Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western |
SEH1 |
YGL100W |
Subunit of the Nup84 nuclear pore and SEACAT subcomplexes |
physical |
5 |
2 |
3 |
Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western |
SLX9 |
YGR081C |
Protein required for pre-rRNA processing |
genetic |
5 |
2 |
3 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
NUP2 |
YLR335W |
Nucleoporin involved in nucleocytoplasmic transport |
genetic |
5 |
2 |
3 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
MLP2 |
YIL149C |
Myosin-like protein associated with the nuclear envelope |
genetic |
5 |
2 |
3 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
SIN3 |
YOL004W |
Component of both the Rpd3S and Rpd3L histone deacetylase complexes |
genetic |
5 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
SEM1 |
YDR363W-A |
19S proteasome regulatory particle lid subcomplex component |
genetic |
5 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
ESC1 |
YMR219W |
Protein involved in telomeric silencing |
genetic |
5 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
NUP116 |
YMR047C |
FG-nucleoporin component of central core of the nuclear pore complex |
physical |
4 |
3 |
4 |
Affinity Capture-MS, Co-purification, Affinity Capture-MS, Reconstituted Complex |
CTF4 |
YPR135W |
Chromatin-associated protein |
genetic |
4 |
3 |
4 |
Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Negative Genetic |
SGS1 |
YMR190C |
RecQ family nucleolar DNA helicase |
genetic |
4 |
3 |
4 |
Synthetic Growth Defect, Synthetic Lethality, Synthetic Growth Defect, Negative Genetic |
SEC13 |
YLR208W |
Structural component of 3 complexes |
physical |
4 |
2 |
4 |
Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western |
XRS2 |
YDR369C |
FHA domain-containing component of the Mre11 complex |
genetic |
4 |
2 |
4 |
Synthetic Lethality, Negative Genetic, Synthetic Lethality, Negative Genetic |
DBP5 |
YOR046C |
Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family |
genetic |
4 |
3 |
3 |
Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect |
UME6 |
YDR207C |
Rpd3L histone deacetylase complex subunit |
genetic |
4 |
2 |
3 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic |
LGE1 |
YPL055C |
Protein involved in histone H2B ubiquitination |
genetic |
4 |
2 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Lethality |
NEM1 |
YHR004C |
Probable catalytic subunit of Nem1p-Spo7p phosphatase holoenzyme |
genetic |
4 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
CIK1 |
YMR198W |
Kinesin-associated protein |
genetic |
4 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
RRP6 |
YOR001W |
Nuclear exosome exonuclease component |
genetic |
4 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
SRC1 |
YML034W |
Inner nuclear membrane protein |
genetic |
4 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
SWR1 |
YDR334W |
Swi2/Snf2-related ATPase |
genetic |
4 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
PBS2 |
YJL128C |
MAP kinase kinase of the HOG signaling pathway |
genetic |
4 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
MMS22 |
YLR320W |
Subunit of E3 ubiquitin ligase complex involved in replication repair |
genetic |
4 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
ESC2 |
YDR363W |
Sumo-like domain protein |
genetic |
4 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
MOG1 |
YJR074W |
Conserved nuclear protein that interacts with GTP-Gsp1p |
genetic |
4 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
PAT1 |
YCR077C |
Deadenylation-dependent mRNA-decapping factor |
genetic |
4 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
UBA4 |
YHR111W |
E1-like protein that activates Urm1p before urmylation |
genetic |
4 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
THP2 |
YHR167W |
Subunit of the THO and TREX complexes |
genetic |
4 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
ASM4 |
YDL088C |
FG-nucleoporin component of central core of nuclear pore complex (NPC) |
genetic |
4 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
RAD55 |
YDR076W |
Protein that stimulates strand exchange |
genetic |
3 |
3 |
3 |
Synthetic Lethality, Negative Genetic, Synthetic Growth Defect |
SRS2 |
YJL092W |
DNA helicase and DNA-dependent ATPase |
genetic |
3 |
3 |
3 |
Synthetic Lethality, Negative Genetic, Synthetic Growth Defect |
SLX5 |
YDL013W |
Subunit of the Slx5-Slx8 SUMO-targeted Ub ligase (STUbL) complex |
genetic |
3 |
3 |
3 |
Positive Genetic, Synthetic Growth Defect, Synthetic Lethality |
CTF18 |
YMR078C |
Subunit of a complex with Ctf8p |
genetic |
3 |
2 |
3 |
Negative Genetic, Synthetic Lethality, Negative Genetic |
RAD54 |
YGL163C |
DNA-dependent ATPase that stimulates strand exchange |
genetic |
3 |
2 |
3 |
Synthetic Lethality, Negative Genetic, Synthetic Lethality |
SLX8 |
YER116C |
Subunit of Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex |
genetic |
3 |
2 |
3 |
Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect |
TOP3 |
YLR234W |
DNA Topoisomerase III |
genetic |
3 |
2 |
3 |
Synthetic Lethality, Negative Genetic, Negative Genetic |
DCC1 |
YCL016C |
Subunit of a complex with Ctf8p and Ctf18p |
genetic |
3 |
2 |
3 |
Negative Genetic, Synthetic Growth Defect, Negative Genetic |
LSM6 |
YDR378C |
Lsm (Like Sm) protein |
genetic |
3 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic |
GIN4 |
YDR507C |
Protein kinase involved in bud growth and assembly of the septin ring |
genetic |
3 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic |
SDC1 |
YDR469W |
Subunit of the COMPASS (Set1C) complex |
genetic |
3 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic |
SWC5 |
YBR231C |
Component of the SWR1 complex |
genetic |
3 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic |
SET2 |
YJL168C |
Histone methyltransferase with a role in transcriptional elongation |
genetic |
3 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic |
WTM1 |
YOR230W |
Transcriptional modulator |
genetic |
3 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic |
GLC7 |
YER133W |
Type 1 S/T protein phosphatase (PP1) catalytic subunit |
genetic |
3 |
2 |
2 |
Synthetic Lethality, Synthetic Lethality, Negative Genetic |
NUP100 |
YKL068W |
FG-nucleoporin component of central core of the nuclear pore complex |
genetic |
3 |
2 |
2 |
Synthetic Lethality, Negative Genetic, Negative Genetic |
CDC73 |
YLR418C |
Component of the Paf1p complex |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
CKB1 |
YGL019W |
Beta regulatory subunit of casein kinase 2 (CK2) |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
KAP95 |
YLR347C |
Karyopherin beta |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
DPB4 |
YDR121W |
Subunit of DNA pol epsilon and of ISW2 chromatin accessibility complex |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
NUP120 |
YKL057C |
Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) |
genetic |
3 |
1 |
2 |
Synthetic Lethality, Synthetic Lethality, Synthetic Lethality |
ALT2 |
YDR111C |
Catalytically inactive alanine transaminase |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
IRA2 |
YOL081W |
GTPase-activating protein |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
ARF1 |
YDL192W |
ADP-ribosylation factor |
genetic |
3 |
1 |
2 |
Positive Genetic, Positive Genetic, Positive Genetic |
CDC20 |
YGL116W |
Activator of anaphase-promoting complex/cyclosome (APC/C) |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
MUS81 |
YDR386W |
Subunit of structure-specific Mms4p-Mus81p endonuclease |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
RPN10 |
YHR200W |
Proteasome polyubiquitin receptor |
genetic |
3 |
1 |
2 |
Positive Genetic, Positive Genetic, Positive Genetic |
SEC66 |
YBR171W |
Non-essential subunit of Sec63 complex |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
YRB1 |
YDR002W |
Ran GTPase binding protein |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
SWF1 |
YDR126W |
Palmitoyltransferase that acts on transmembrane proteins |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
SRM1 |
YGL097W |
Nucleotide exchange factor for Gsp1p |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
SEC28 |
YIL076W |
Epsilon-COP subunit of the coatomer |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
URM1 |
YIL008W |
Ubiquitin-like protein involved in thiolation of cytoplasmic tRNAs |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
RSB1 |
YOR049C |
Sphingoid long-chain base (LCB) efflux transporter |
genetic |
3 |
1 |
2 |
Positive Genetic, Positive Genetic, Positive Genetic |
TUM1 |
YOR251C |
Rhodanese domain sulfur transferase |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
ARP6 |
YLR085C |
Actin-related protein that binds nucleosomes |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
ATG8 |
YBL078C |
Ub-like protein |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
MEX67 |
YPL169C |
Poly(A)RNA binding protein involved in nuclear mRNA export |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
NMD2 |
YHR077C |
Protein involved in the nonsense-mediated mRNA decay (NMD) pathway |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
DPC29 |
YGR021W |
Putative mitochondrial protein of unknown function |
genetic |
3 |
1 |
2 |
Positive Genetic, Positive Genetic, Positive Genetic |
HAC1 |
YFL031W |
Basic leucine zipper (bZIP) transcription factor (ATF/CREB1 homolog) |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
INP51 |
YIL002C |
Phosphatidylinositol 4,5-bisphosphate 5-phosphatase |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
ADI1 |
YMR009W |
Acireductone dioxygenease involved in methionine salvage pathway |
genetic |
3 |
1 |
2 |
Positive Genetic, Positive Genetic, Positive Genetic |
JID1 |
YPR061C |
Probable Hsp40p co-chaperone |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
CWH41 |
YGL027C |
Processing alpha glucosidase I |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
AVT5 |
YBL089W |
Putative transporter |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
NCS6 |
YGL211W |
Protein required for uridine thiolation of Gln, Lys, and Glu tRNAs |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
CPR8 |
YNR028W |
Peptidyl-prolyl cis-trans isomerase (cyclophilin) |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
IZH1 |
YDR492W |
Membrane protein involved in zinc ion homeostasis |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
NUP116 |
YMR047C |
FG-nucleoporin component of central core of the nuclear pore complex |
genetic |
2 |
2 |
2 |
Negative Genetic, Synthetic Growth Defect |
CDC13 |
YDL220C |
Single stranded DNA-binding protein found at TG1-3 telomere G-tails |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Negative Genetic |
MMS4 |
YBR098W |
Subunit of structure-specific Mms4p-Mus81p endonuclease |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Negative Genetic |
NUP157 |
YER105C |
Subunit of the inner ring of the nuclear pore complex (NPC) |
physical |
2 |
2 |
2 |
Reconstituted Complex, Affinity Capture-MS |
ULP1 |
YPL020C |
Protease that specifically cleaves Smt3p protein conjugates |
physical |
2 |
2 |
2 |
PCA, Affinity Capture-MS |
SOD1 |
YJR104C |
Cytosolic copper-zinc superoxide dismutase |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Negative Genetic |
TOF1 |
YNL273W |
Subunit of a replication-pausing checkpoint complex |
genetic |
2 |
2 |
2 |
Negative Genetic, Synthetic Growth Defect |
SUB2 |
YDL084W |
Component of the TREX complex required for nuclear mRNA export |
genetic |
2 |
2 |
2 |
Dosage Growth Defect, Negative Genetic |
TOP1 |
YOL006C |
Topoisomerase I |
genetic |
2 |
2 |
2 |
Synthetic Rescue, Synthetic Growth Defect |
SBA1 |
YKL117W |
Co-chaperone that binds and regulates Hsp90 family chaperones |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Negative Genetic |
SMT3 |
YDR510W |
Ubiquitin-like protein of the SUMO family |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Negative Genetic |
BIM1 |
YER016W |
Microtubule plus end-tracking protein |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Negative Genetic |
CSM3 |
YMR048W |
Replication fork associated factor |
genetic |
2 |
2 |
2 |
Negative Genetic, Synthetic Growth Defect |
GCR1 |
YPL075W |
Transcriptional activator of genes involved in glycolysis |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Phenotypic Enhancement |
CTF8 |
YHR191C |
Subunit of a complex with Ctf18p |
genetic |
2 |
2 |
2 |
Positive Genetic, Synthetic Growth Defect |
NAB2 |
YGL122C |
Nuclear polyadenylated RNA-binding protein |
physical |
2 |
1 |
2 |
Affinity Capture-MS, Affinity Capture-MS |
BUD31 |
YCR063W |
Component of the SF3b subcomplex of the U2 snRNP |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
DPB3 |
YBR278W |
Third-largest subunit of DNA polymerase II (DNA polymerase epsilon) |
genetic |
2 |
1 |
2 |
Positive Genetic, Positive Genetic |
ENP1 |
YBR247C |
Protein associated with U3 and U14 snoRNAs |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
EAF3 |
YPR023C |
Component of the Rpd3S histone deacetylase complex |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
DHH1 |
YDL160C |
Cytoplasmic DEAD-box helicase and mRNA decapping activator |
physical |
2 |
1 |
2 |
Affinity Capture-RNA, Affinity Capture-RNA |
ISW1 |
YBR245C |
ATPase subunit of imitation-switch (ISWI) class chromatin remodelers |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
CRM1 |
YGR218W |
Nuclear export factor, exportin |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
COG3 |
YER157W |
Essential component of the conserved oligomeric Golgi complex |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
EHD3 |
YDR036C |
3-hydroxyisobutyryl-CoA hydrolase |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
ATG3 |
YNR007C |
E2-like enzyme |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
HTZ1 |
YOL012C |
Histone variant H2AZ |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
GLE2 |
YER107C |
RNA export factor associated with the nuclear pore complex (NPC) |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
BCY1 |
YIL033C |
Regulatory subunit of the cyclic AMP-dependent protein kinase (PKA) |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
LSM12 |
YHR121W |
Protein of unknown function that may function in RNA processing |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
FDO1 |
YMR144W |
Protein involved in directionality of mating type switching |
genetic |
2 |
1 |
2 |
Positive Genetic, Positive Genetic |
DYN2 |
YDR424C |
Cytoplasmic light chain dynein, microtubule motor protein |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
GDB1 |
YPR184W |
Glycogen debranching enzyme |
genetic |
2 |
1 |
2 |
Positive Genetic, Positive Genetic |
LSC1 |
YOR142W |
Alpha subunit of succinyl-CoA ligase |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
APE3 |
YBR286W |
Vacuolar aminopeptidase Y |
genetic |
2 |
1 |
2 |
Positive Genetic, Positive Genetic |
NUP42 |
YDR192C |
FG-nucleoporin component of central core of the nuclear pore complex |
physical |
2 |
1 |
2 |
Affinity Capture-MS, Affinity Capture-MS |
NUP49 |
YGL172W |
FG-nucleoporin component of central core of the nuclear pore complex |
physical |
2 |
1 |
2 |
Affinity Capture-MS, Affinity Capture-MS |
NUP57 |
YGR119C |
FG-nucleoporin component of central core of the nuclear pore complex |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
NUP82 |
YJL061W |
Linker nucleoporin component of the nuclear pore complex (NPC) |
physical |
2 |
1 |
2 |
Affinity Capture-MS, Affinity Capture-MS |
NUP157 |
YER105C |
Subunit of the inner ring of the nuclear pore complex (NPC) |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
VPS72 |
YDR485C |
Htz1p-binding component of the SWR1 complex |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
RMI1 |
YPL024W |
Subunit of the RecQ (Sgs1p) - Topo III (Top3p) complex |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
PHO23 |
YNL097C |
Component of the Rpd3L histone deacetylase complex |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
SUS1 |
YBR111W-A |
Global transcriptional regulator, component of SAGA, TREX-2 complexes |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
YBR284W |
YBR284W |
Putative metallo-dependent hydrolase superfamily protein |
genetic |
2 |
1 |
2 |
Positive Genetic, Positive Genetic |
PCA1 |
YBR295W |
Cadmium transporting P-type ATPase |
genetic |
2 |
1 |
2 |
Positive Genetic, Positive Genetic |
YCL001W-A |
YCL001W-A |
Putative protein of unknown function |
genetic |
2 |
1 |
2 |
Positive Genetic, Positive Genetic |
RBK1 |
YCR036W |
Ribokinase, phosphorylates ribose to ribose-5-phosphate |
genetic |
2 |
1 |
2 |
Positive Genetic, Positive Genetic |
YCR087C-A |
YCR087C-A |
Putative protein of unknown function |
genetic |
2 |
1 |
2 |
Positive Genetic, Positive Genetic |
TPC1 |
YGR096W |
Mitochondrial membrane transporter |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
PPE1 |
YHR075C |
Protein with carboxyl methyl esterase activity |
genetic |
2 |
1 |
2 |
Positive Genetic, Positive Genetic |
SDP1 |
YIL113W |
Stress-inducible dual-specificity MAP kinase phosphatase |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
RPS21B |
YJL136C |
Protein component of the small (40S) ribosomal subunit |
genetic |
2 |
1 |
2 |
Positive Genetic, Positive Genetic |
VTA1 |
YLR181C |
Multivesicular body (MVB) protein |
genetic |
2 |
1 |
2 |
Positive Genetic, Positive Genetic |
VPS38 |
YLR360W |
Part of a Vps34p phosphatidylinositol 3-kinase complex |
genetic |
2 |
1 |
2 |
Positive Genetic, Positive Genetic |
SEI1 |
YLR404W |
Seipin involved in lipid droplet (LD) assembly |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
OST6 |
YML019W |
Subunit of the oligosaccharyltransferase complex of the ER lumen |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
PPZ1 |
YML016C |
Serine/threonine protein phosphatase Z, isoform of Ppz2p |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
SOL1 |
YNR034W |
Protein with a possible role in tRNA export |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
SLP1 |
YOR154W |
Glycosylated integral ER membrane protein of unknown function |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
PRM4 |
YPL156C |
Pheromone-regulated protein proposed to be involved in mating |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
POC4 |
YPL144W |
Component of a heterodimeric Poc4p-Irc25p chaperone |
genetic |
2 |
1 |
2 |
Positive Genetic, Positive Genetic |
URN1 |
YPR152C |
Protein of unknown function containing WW and FF domains |
genetic |
2 |
1 |
2 |
Positive Genetic, Positive Genetic |
PAH1 |
YMR165C |
Mg2+-dependent phosphatidate (PA) phosphatase |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
RPD3 |
YNL330C |
Histone deacetylase, component of both the Rpd3S and Rpd3L complexes |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
SNT309 |
YPR101W |
Member of the NineTeen Complex (NTC) |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
PTK2 |
YJR059W |
Serine/threonine protein kinase |
genetic |
2 |
1 |
2 |
Positive Genetic, Positive Genetic |
KKQ8 |
YKL168C |
Putative serine/threonine protein kinase with unknown cellular role |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
MLP2 |
YIL149C |
Myosin-like protein associated with the nuclear envelope |
physical |
2 |
1 |
2 |
Affinity Capture-MS, Affinity Capture-MS |
CPR2 |
YHR057C |
Peptidyl-prolyl cis-trans isomerase (cyclophilin) |
genetic |
2 |
1 |
2 |
Positive Genetic, Positive Genetic |
AIM4 |
YBR194W |
Protein proposed to be associated with the nuclear pore complex |
genetic |
2 |
1 |
2 |
Positive Genetic, Positive Genetic |
ATG8 |
YBL078C |
Ub-like protein |
physical |
2 |
1 |
2 |
Affinity Capture-MS, Affinity Capture-MS |
MEX67 |
YPL169C |
Poly(A)RNA binding protein involved in nuclear mRNA export |
physical |
2 |
1 |
2 |
Affinity Capture-MS, Affinity Capture-MS |
NIS1 |
YNL078W |
Protein involved in axial bud site selection |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
BRL1 |
YHR036W |
Essential nuclear envelope/ER integral membrane protein |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
MTC1 |
YJL123C |
Protein of unknown function that may interact with ribosomes |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
MUB1 |
YMR100W |
MYND domain-containing protein |
genetic |
2 |
1 |
2 |
Positive Genetic, Positive Genetic |
JJJ2 |
YJL162C |
Protein of unknown function |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
CHS6 |
YJL099W |
Member of the ChAPs (Chs5p-Arf1p-binding proteins) family |
genetic |
2 |
1 |
2 |
Synthetic Growth Defect, Synthetic Growth Defect |
CMR3 |
YPR013C |
Putative zinc finger protein |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
ECM22 |
YLR228C |
Sterol regulatory element binding protein |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
CHS7 |
YHR142W |
Protein of unknown function |
genetic |
2 |
1 |
2 |
Synthetic Growth Defect, Synthetic Growth Defect |
MRN1 |
YPL184C |
RNA-binding protein that may be involved in translational regulation |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
MSN1 |
YOL116W |
Transcriptional activator |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
NCS2 |
YNL119W |
Protein required for uridine thiolation of Lys(UUU) and Glu(UUC) tRNAs |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
MAL33 |
YBR297W |
MAL-activator protein |
genetic |
2 |
1 |
2 |
Positive Genetic, Positive Genetic |
EMP65 |
YER140W |
Integral membrane protein of the ER |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
NPP1 |
YCR026C |
Nucleotide pyrophosphatase/phosphodiesterase |
genetic |
2 |
1 |
2 |
Positive Genetic, Positive Genetic |
CMR1 |
YDL156W |
Nuclear protein with role in transcription, protein quality control |
physical |
2 |
1 |
1 |
PCA, PCA |
CCT6 |
YDR188W |
Subunit of the cytosolic chaperonin Cct ring complex |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
GET2 |
YER083C |
Subunit of the GET complex |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
GLE1 |
YDL207W |
Cytoplasmic nucleoporin required for polyadenylated mRNA export |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
NUP188 |
YML103C |
Subunit of the inner ring of the nuclear pore complex (NPC) |
physical |
2 |
1 |
1 |
FRET, FRET |
NUP145 |
YGL092W |
Essential protein with distinct roles in two nuclear pore subcomplexes |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
PTC2 |
YER089C |
Type 2C protein phosphatase (PP2C) |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
PBP1 |
YGR178C |
Component of glucose deprivation induced stress granules |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
SDS3 |
YIL084C |
Component of the Rpd3L histone deacetylase complex |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
RCN1 |
YKL159C |
Protein involved in calcineurin regulation during calcium signaling |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
SSS1 |
YDR086C |
Subunit of the Sec61p translocation complex (Sec61p-Sss1p-Sbh1p) |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
TAH11 |
YJR046W |
DNA replication licensing factor |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
SPC24 |
YMR117C |
Component of the kinetochore-associated Ndc80 complex |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
IRE1 |
YHR079C |
Serine-threonine kinase and endoribonuclease |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
ATG39 |
YLR312C |
Transmembrane receptor with a role in nucleophagy |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
COG6 |
YNL041C |
Component of the conserved oligomeric Golgi complex |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
ARO2 |
YGL148W |
Bifunctional chorismate synthase and flavin reductase |
genetic |
2 |
1 |
1 |
Positive Genetic, Positive Genetic |
CHO2 |
YGR157W |
Phosphatidylethanolamine methyltransferase (PEMT) |
genetic |
2 |
1 |
1 |
Positive Genetic, Positive Genetic |
BRR6 |
YGL247W |
Essential nuclear envelope integral membrane protein |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
APQ12 |
YIL040W |
Nuclear envelope/ER integral membrane protein |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
FKH1 |
YIL131C |
Forkhead family transcription factor |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
MSN2 |
YMR037C |
Stress-responsive transcriptional activator |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
TFC7 |
YOR110W |
RNA pol III transcription initiation factor complex (TFIIIC) subunit |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
CHL4 |
YDR254W |
Outer kinetochore protein required for chromosome stability |
genetic |
1 |
1 |
1 |
Negative Genetic |
CKA1 |
YIL035C |
Alpha catalytic subunit of casein kinase 2 (CK2) |
genetic |
1 |
1 |
1 |
Negative Genetic |
CKA2 |
YOR061W |
Alpha' catalytic subunit of casein kinase 2 (CK2) |
genetic |
1 |
1 |
1 |
Negative Genetic |
MMS21 |
YEL019C |
Highly conserved SUMO E3 ligase subunit of SMC5-SMC6 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
NSE3 |
YDR288W |
Component of the SMC5-SMC6 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
ESA1 |
YOR244W |
Catalytic subunit of the histone acetyltransferase complex (NuA4) |
genetic |
1 |
1 |
1 |
Negative Genetic |
ERB1 |
YMR049C |
Constituent of 66S pre-ribosomal particles |
genetic |
1 |
1 |
1 |
Negative Genetic |
NOG1 |
YPL093W |
Putative GTPase |
genetic |
1 |
1 |
1 |
Positive Genetic |
KAP123 |
YER110C |
Karyopherin beta |
genetic |
1 |
1 |
1 |
Negative Genetic |
BRR2 |
YER172C |
RNA-dependent ATPase RNA helicase (DEIH box) |
genetic |
1 |
1 |
1 |
Negative Genetic |
NSE4 |
YDL105W |
Component of the SMC5-SMC6 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
BRE1 |
YDL074C |
E3 ubiquitin ligase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
MCM21 |
YDR318W |
Component of the kinetochore sub-complex COMA |
genetic |
1 |
1 |
1 |
Negative Genetic |
NAT3 |
YPR131C |
Catalytic subunit of the NatB N-terminal acetyltransferase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
IML1 |
YJR138W |
GTPase-activating protein (GAP) subunit of the Iml1p/SEACIT complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
CSL4 |
YNL232W |
Exosome non-catalytic core component |
genetic |
1 |
1 |
1 |
Negative Genetic |
LRP1 |
YHR081W |
Nuclear exosome-associated nucleic acid binding protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
MFT1 |
YML062C |
Subunit of the THO complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
ARP7 |
YPR034W |
Component of both the SWI/SNF and RSC chromatin remodeling complexes |
genetic |
1 |
1 |
1 |
Negative Genetic |
ACT1 |
YFL039C |
Actin, structural protein in cytoskeleton |
genetic |
1 |
1 |
1 |
Synthetic Haploinsufficiency |
GCD2 |
YGR083C |
Delta subunit of the translation initiation factor eIF2B |
genetic |
1 |
1 |
1 |
Negative Genetic |
CFT2 |
YLR115W |
Subunit of the mRNA cleavage and polyadenlylation factor (CPF) |
genetic |
1 |
1 |
1 |
Negative Genetic |
CCR4 |
YAL021C |
Component of the CCR4-NOT transcriptional complex |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
CDC39 |
YCR093W |
Subunit of the CCR4-NOT1 core complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
BMS1 |
YPL217C |
GTPase required for ribosomal subunit synthesis and rRNA processing |
genetic |
1 |
1 |
1 |
Positive Genetic |
ARD1 |
YHR013C |
Subunit of protein N-terminal acetyltransferase NatA |
genetic |
1 |
1 |
1 |
Positive Genetic |
ASF1 |
YJL115W |
Nucleosome assembly factor |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
BEM1 |
YBR200W |
Protein containing SH3-domains |
genetic |
1 |
1 |
1 |
Negative Genetic |
ASC1 |
YMR116C |
G-protein beta subunit and guanine dissociation inhibitor for Gpa2p |
genetic |
1 |
1 |
1 |
Positive Genetic |
CDC11 |
YJR076C |
Component of the septin ring that is required for cytokinesis |
genetic |
1 |
1 |
1 |
Negative Genetic |
CDC3 |
YLR314C |
Component of the septin ring that is required for cytokinesis |
genetic |
1 |
1 |
1 |
Negative Genetic |
CDC55 |
YGL190C |
Regulatory subunit B of protein phosphatase 2A (PP2A) |
genetic |
1 |
1 |
1 |
Negative Genetic |
CEG1 |
YGL130W |
Guanylyltransferase involved in mRNA 5' capping |
genetic |
1 |
1 |
1 |
Negative Genetic |
AVO1 |
YOL078W |
Component of the membrane-bound TORC2 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
CKS1 |
YBR135W |
Cyclin-dependent protein kinase regulatory subunit and adaptor |
genetic |
1 |
1 |
1 |
Negative Genetic |
CTK1 |
YKL139W |
Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I) |
genetic |
1 |
1 |
1 |
Negative Genetic |
CDC23 |
YHR166C |
Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) |
genetic |
1 |
1 |
1 |
Negative Genetic |
FIP1 |
YJR093C |
Subunit of cleavage polyadenylation factor (CPF) |
genetic |
1 |
1 |
1 |
Negative Genetic |
GCN2 |
YDR283C |
Protein kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
IML3 |
YBR107C |
Outer kinetochore protein and component of the Ctf19 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
IPP1 |
YBR011C |
Cytoplasmic inorganic pyrophosphatase (PPase) |
genetic |
1 |
1 |
1 |
Negative Genetic |
IOC3 |
YFR013W |
Subunit of the Isw1a complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
ISW1 |
YBR245C |
ATPase subunit of imitation-switch (ISWI) class chromatin remodelers |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
LSM7 |
YNL147W |
Lsm (Like Sm) protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
FAB1 |
YFR019W |
1-phosphatidylinositol-3-phosphate 5-kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
MRP49 |
YKL167C |
Mitochondrial ribosomal protein of the large subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
MEC1 |
YBR136W |
Genome integrity checkpoint protein and PI kinase superfamily member |
genetic |
1 |
1 |
1 |
Negative Genetic |
MTR10 |
YOR160W |
Nuclear import receptor |
genetic |
1 |
1 |
1 |
Negative Genetic |
NMD3 |
YHR170W |
Protein involved in nuclear export of the large ribosomal subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
FAS2 |
YPL231W |
Alpha subunit of fatty acid synthetase |
genetic |
1 |
1 |
1 |
Negative Genetic |
NOT3 |
YIL038C |
Component of the CCR4-NOT core complex, involved in mRNA decapping |
genetic |
1 |
1 |
1 |
Negative Genetic |
NPL4 |
YBR170C |
Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase |
genetic |
1 |
1 |
1 |
Negative Genetic |
NIC96 |
YFR002W |
Linker nucleoporin component of the nuclear pore complex (NPC) |
genetic |
1 |
1 |
1 |
Negative Genetic |
NSP1 |
YJL041W |
FG-nucleoporin component of central core of the nuclear pore complex |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
NSP1 |
YJL041W |
FG-nucleoporin component of central core of the nuclear pore complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
DIG1 |
YPL049C |
MAP kinase-responsive inhibitor of the Ste12p transcription factor |
genetic |
1 |
1 |
1 |
Positive Genetic |
HTA1 |
YDR225W |
Histone H2A |
genetic |
1 |
1 |
1 |
Negative Genetic |
DAM1 |
YGR113W |
Essential subunit of the Dam1 complex (aka DASH complex) |
genetic |
1 |
1 |
1 |
Negative Genetic |
NOP14 |
YDL148C |
Nucleolar protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
FYV8 |
YGR196C |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
DEP1 |
YAL013W |
Component of the Rpd3L histone deacetylase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
CTI6 |
YPL181W |
Component of the Rpd3L histone deacetylase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
MTR3 |
YGR158C |
Exosome non-catalytic core component |
genetic |
1 |
1 |
1 |
Negative Genetic |
CSE1 |
YGL238W |
Nuclear envelope protein that acts as a recycling factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
CCT2 |
YIL142W |
Subunit beta of the cytosolic chaperonin Cct ring complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
GCN5 |
YGR252W |
Catalytic subunit of ADA and SAGA histone acetyltransferase complexes |
genetic |
1 |
1 |
1 |
Negative Genetic |
MLP1 |
YKR095W |
Myosin-like protein associated with the nuclear envelope |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
CRN1 |
YLR429W |
Coronin |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
MGA2 |
YIR033W |
ER membrane protein involved in regulation of OLE1 transcription |
genetic |
1 |
1 |
1 |
Negative Genetic |
BET5 |
YML077W |
Core component of transport protein particle (TRAPP) complexes I-III |
genetic |
1 |
1 |
1 |
Negative Genetic |
BDH2 |
YAL061W |
Putative medium-chain alcohol dehydrogenase with similarity to BDH1 |
genetic |
1 |
1 |
1 |
Positive Genetic |
BRE2 |
YLR015W |
Subunit of COMPASS (Set1C) complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
FES1 |
YBR101C |
Hsp70 (Ssa1p) nucleotide exchange factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
HYP2 |
YEL034W |
Translation elongation factor eIF-5A |
genetic |
1 |
1 |
1 |
Positive Genetic |
HIR3 |
YJR140C |
Subunit of the HIR complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
GSP2 |
YOR185C |
GTP binding protein (mammalian Ranp homolog) |
genetic |
1 |
1 |
1 |
Negative Genetic |
GSP1 |
YLR293C |
Ran GTPase |
genetic |
1 |
1 |
1 |
Negative Genetic |
GRR1 |
YJR090C |
F-box protein component of an SCF ubiquitin-ligase complex |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
DUN1 |
YDL101C |
Cell-cycle checkpoint S/T protein kinase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
ATG12 |
YBR217W |
Ubiquitin-like modifier involved in autophagy and the Cvt pathway |
genetic |
1 |
1 |
1 |
Negative Genetic |
HSP104 |
YLL026W |
Disaggregase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
DYN2 |
YDR424C |
Cytoplasmic light chain dynein, microtubule motor protein |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
DMA1 |
YHR115C |
Ubiquitin-protein ligase (E3) |
genetic |
1 |
1 |
1 |
Negative Genetic |
GPN3 |
YLR243W |
Putative GTPase with a role in biogenesis of RNA pol II and polIII |
genetic |
1 |
1 |
1 |
Positive Genetic |
GLE1 |
YDL207W |
Cytoplasmic nucleoporin required for polyadenylated mRNA export |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
NTF2 |
YER009W |
Nuclear envelope protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
NPA3 |
YJR072C |
Member of the conserved GPN-loop GTPase family |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
HIR1 |
YBL008W |
Subunit of the HIR complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
GAL7 |
YBR018C |
Galactose-1-phosphate uridyl transferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
CDC15 |
YAR019C |
Hippo-like kinase of the Mitotic Exit Network |
physical |
1 |
1 |
1 |
Proximity Label-MS |
KRI1 |
YNL308C |
Essential nucleolar protein required for 40S ribosome biogenesis |
genetic |
1 |
1 |
1 |
Positive Genetic |
DIA2 |
YOR080W |
Origin-binding F-box protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
DPB11 |
YJL090C |
DNA replication initiation protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
ELG1 |
YOR144C |
Subunit of an alternative replication factor C complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
FKH2 |
YNL068C |
Forkhead family transcription factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
BUB3 |
YOR026W |
Kinetochore checkpoint WD40 repeat protein |
genetic |
1 |
1 |
1 |
Positive Genetic |
MSG5 |
YNL053W |
Dual-specificity protein phosphatase |
genetic |
1 |
1 |
1 |
Negative Genetic |
CHZ1 |
YER030W |
Histone chaperone for Htz1p/H2A-H2B dimer |
genetic |
1 |
1 |
1 |
Negative Genetic |
CDC7 |
YDL017W |
S/T kinase and catalytic subunit of DDK (Dbf4-dependent kinase) |
genetic |
1 |
1 |
1 |
Positive Genetic |
PSE1 |
YMR308C |
Karyopherin/importin that interacts with the nuclear pore complex |
physical |
1 |
1 |
1 |
FRET |
NUP84 |
YDL116W |
Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
NUP49 |
YGL172W |
FG-nucleoporin component of central core of the nuclear pore complex |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
NUP57 |
YGR119C |
FG-nucleoporin component of central core of the nuclear pore complex |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
NUP159 |
YIL115C |
FG-nucleoporin component of central core of the nuclear pore complex |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
NUP159 |
YIL115C |
FG-nucleoporin component of central core of the nuclear pore complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
NUP82 |
YJL061W |
Linker nucleoporin component of the nuclear pore complex (NPC) |
genetic |
1 |
1 |
1 |
Negative Genetic |
UBA1 |
YKL210W |
Ubiquitin activating enzyme (E1) |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
NUP85 |
YJR042W |
Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
SAC3 |
YDR159W |
mRNA export factor |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
SAC3 |
YDR159W |
mRNA export factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
RPN11 |
YFR004W |
Metalloprotease subunit of 19S regulatory particle |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RRP17 |
YDR412W |
5' exoribonuclease required for 5' end processing of pre-60S rRNA |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
TEF1 |
YPR080W |
Translational elongation factor EF-1 alpha |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
NUP53 |
YMR153W |
FG-nucleoporin component of central core of nuclear pore complex (NPC) |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
ULP1 |
YPL020C |
Protease that specifically cleaves Smt3p protein conjugates |
genetic |
1 |
1 |
1 |
Dosage Rescue |
SSB2 |
YNL209W |
Cytoplasmic ATPase that is a ribosome-associated molecular chaperone |
physical |
1 |
1 |
1 |
Co-purification |
PUF2 |
YPR042C |
PUF family mRNA-binding protein |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
NUP60 |
YAR002W |
FG-nucleoporin component of central core of the nuclear pore complex |
physical |
1 |
1 |
1 |
Reconstituted Complex |
SIR4 |
YDR227W |
SIR protein involved in assembly of silent chromatin domains |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
SEC61 |
YLR378C |
Conserved ER protein translocation channel |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
UBP15 |
YMR304W |
Ubiquitin-specific protease involved in protein deubiquitination |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
TEM1 |
YML064C |
GTPase involved in initiation of Mitotic Exit Network (MEN) |
physical |
1 |
1 |
1 |
Proximity Label-MS |
POL32 |
YJR043C |
Third subunit of DNA polymerase delta |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
RAD59 |
YDL059C |
Protein involved DNA double-strand break repair |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
THP1 |
YOL072W |
Nuclear pore-associated protein |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
STT4 |
YLR305C |
Phosphatidylinositol-4-kinase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
SWD1 |
YAR003W |
Subunit of the COMPASS (Set1C) complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
RXT3 |
YDL076C |
Component of the Rpd3L histone deacetylase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
PGD1 |
YGL025C |
Subunit of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
SWD3 |
YBR175W |
Essential subunit of the COMPASS (Set1C) complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
RAD53 |
YPL153C |
DNA damage response kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
SGF73 |
YGL066W |
Subunit of DUBm module of SAGA and SLIK |
genetic |
1 |
1 |
1 |
Positive Genetic |
SLK19 |
YOR195W |
Kinetochore-associated protein |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
RAD9 |
YDR217C |
DNA damage-dependent checkpoint protein |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
SOH1 |
YGL127C |
Subunit of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
SWI3 |
YJL176C |
Subunit of the SWI/SNF chromatin remodeling complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
SAT4 |
YCR008W |
Ser/Thr protein kinase involved in salt tolerance, nutrient response |
genetic |
1 |
1 |
1 |
Negative Genetic |
YJL070C |
YJL070C |
Putative metallo-dependent hydrolase superfamily protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
YKL069W |
YKL069W |
Methionine-R-sulfoxide reductase |
genetic |
1 |
1 |
1 |
Negative Genetic |
OAR1 |
YKL055C |
Mitochondrial 3-oxoacyl-[acyl-carrier-protein] reductase |
genetic |
1 |
1 |
1 |
Negative Genetic |
VRP1 |
YLR337C |
Verprolin, proline-rich actin-associated protein |
genetic |
1 |
1 |
1 |
Positive Genetic |
YLR415C |
YLR415C |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
SAM37 |
YMR060C |
Component of the Sorting and Assembly Machinery (SAM) complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
YME1 |
YPR024W |
Catalytic subunit of i-AAA protease complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
YHC1 |
YLR298C |
Component of the U1 snRNP complex required for pre-mRNA splicing |
genetic |
1 |
1 |
1 |
Positive Genetic |
ORM2 |
YLR350W |
Protein that mediates sphingolipid homeostasis |
genetic |
1 |
1 |
1 |
Negative Genetic |
SIR2 |
YDL042C |
Conserved NAD+ dependent histone deacetylase of the Sirtuin family |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
PER33 |
YLR064W |
Protein that localizes to the endoplasmic reticulum |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
PAP2 |
YOL115W |
Non-canonical poly(A) polymerase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
VMA21 |
YGR105W |
Integral membrane protein required for V-ATPase function |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
VOA1 |
YGR106C |
ER protein that functions in assembly of the V0 sector of V-ATPase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
SKY1 |
YMR216C |
SR protein kinase (SRPK) |
genetic |
1 |
1 |
1 |
Positive Genetic |
RSF2 |
YJR127C |
Zinc-finger protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
RXT2 |
YBR095C |
Component of the histone deacetylase Rpd3L complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
SNF1 |
YDR477W |
AMP-activated S/T protein kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
YAK1 |
YJL141C |
Serine-threonine protein kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
SSK2 |
YNR031C |
MAP kinase kinase kinase of HOG1 mitogen-activated signaling pathway |
genetic |
1 |
1 |
1 |
Negative Genetic |
UPC2 |
YDR213W |
Sterol regulatory element binding protein |
genetic |
1 |
1 |
1 |
Positive Genetic |
TYE7 |
YOR344C |
Serine-rich protein that contains a bHLH DNA binding motif |
genetic |
1 |
1 |
1 |
Positive Genetic |
TPK3 |
YKL166C |
cAMP-dependent protein kinase catalytic subunit |
genetic |
1 |
1 |
1 |
Positive Genetic |
YPS1 |
YLR120C |
Aspartic protease |
genetic |
1 |
1 |
1 |
Negative Genetic |
SIP3 |
YNL257C |
Putative sterol transfer protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
UME1 |
YPL139C |
Component of both the Rpd3S and Rpd3L histone deacetylase complexes |
genetic |
1 |
1 |
1 |
Negative Genetic |
PPH3 |
YDR075W |
Catalytic subunit of protein phosphatase PP4 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
PPZ2 |
YDR436W |
Serine/threonine protein phosphatase Z, isoform of Ppz1p |
genetic |
1 |
1 |
1 |
Negative Genetic |
TEL1 |
YBL088C |
Protein kinase primarily involved in telomere length regulation |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
TTI1 |
YKL033W |
Subunit of the ASTRA complex, involved in chromatin remodeling |
genetic |
1 |
1 |
1 |
Negative Genetic |
SEY1 |
YOR165W |
Dynamin-like GTPase that mediates homotypic ER fusion |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
RTN1 |
YDR233C |
Reticulon protein |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
POL2 |
YNL262W |
Catalytic subunit of DNA polymerase (II) epsilon |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
POP1 |
YNL221C |
Subunit of RNase MRP, nuclear RNase P and telomerase complexes |
genetic |
1 |
1 |
1 |
Positive Genetic |
SGT1 |
YOR057W |
Cochaperone protein |
genetic |
1 |
1 |
1 |
Positive Genetic |
YAT2 |
YER024W |
Carnitine acetyltransferase |
genetic |
1 |
1 |
1 |
Positive Genetic |
TPS1 |
YBR126C |
Synthase subunit of trehalose-6-P synthase/phosphatase complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
VHC1 |
YBR235W |
Vacuolar membrane cation-chloride cotransporter (CCC) |
genetic |
1 |
1 |
1 |
Positive Genetic |
SSH1 |
YBR283C |
Subunit of the Ssh1 translocon complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
RRT12 |
YCR045C |
Probable subtilisin-family protease |
genetic |
1 |
1 |
1 |
Positive Genetic |
YCR050C |
YCR050C |
Non-essential protein of unknown function |
genetic |
1 |
1 |
1 |
Positive Genetic |
RPN4 |
YDL020C |
Transcription factor that stimulates expression of proteasome genes |
genetic |
1 |
1 |
1 |
Positive Genetic |
VAM6 |
YDL077C |
Guanine nucleotide exchange factor for the GTPase Gtr1p |
genetic |
1 |
1 |
1 |
Positive Genetic |
RPP1A |
YDL081C |
Ribosomal stalk protein P1 alpha |
genetic |
1 |
1 |
1 |
Positive Genetic |
RVS167 |
YDR388W |
Calmodulin-binding actin-associated protein |
genetic |
1 |
1 |
1 |
Positive Genetic |
UBP6 |
YFR010W |
Ubiquitin-specific protease |
genetic |
1 |
1 |
1 |
Positive Genetic |
XRN1 |
YGL173C |
Evolutionarily-conserved 5'-3' exonuclease |
genetic |
1 |
1 |
1 |
Positive Genetic |
OSH3 |
YHR073W |
Member of an oxysterol-binding protein family |
genetic |
1 |
1 |
1 |
Positive Genetic |
STB5 |
YHR178W |
Transcription factor |
genetic |
1 |
1 |
1 |
Positive Genetic |
SET4 |
YJL105W |
Chromatin-associated protein involved in control of stress response |
genetic |
1 |
1 |
1 |
Positive Genetic |
YLR278C |
YLR278C |
Zinc-cluster protein |
genetic |
1 |
1 |
1 |
Positive Genetic |
TSR2 |
YLR435W |
Protein with a potential role in pre-rRNA processing |
genetic |
1 |
1 |
1 |
Positive Genetic |
VAM3 |
YOR106W |
Syntaxin-like vacuolar t-SNARE |
genetic |
1 |
1 |
1 |
Positive Genetic |
PUT4 |
YOR348C |
Proline permease |
genetic |
1 |
1 |
1 |
Positive Genetic |
SCS7 |
YMR272C |
Sphingolipid alpha-hydroxylase |
genetic |
1 |
1 |
1 |
Positive Genetic |
REB1 |
YBR049C |
RNA polymerase I enhancer binding protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
RRP43 |
YCR035C |
Exosome non-catalytic core component |
genetic |
1 |
1 |
1 |
Negative Genetic |
RSC6 |
YCR052W |
Component of the RSC chromatin remodeling complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
UBC1 |
YDR177W |
Ubiquitin-conjugating enzyme |
genetic |
1 |
1 |
1 |
Negative Genetic |
SEC26 |
YDR238C |
Essential beta-coat protein of the COPI coatomer |
genetic |
1 |
1 |
1 |
Negative Genetic |
TRS23 |
YDR246W |
Core component of transport protein particle (TRAPP) complexes I-III |
genetic |
1 |
1 |
1 |
Negative Genetic |
YRA1 |
YDR381W |
Nuclear polyadenylated RNA-binding protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
SPP41 |
YDR464W |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
SNM1 |
YDR478W |
Ribonuclease MRP complex subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
SCC4 |
YER147C |
Subunit of cohesin loading factor (Scc2p-Scc4p) |
genetic |
1 |
1 |
1 |
Negative Genetic |
TUB2 |
YFL037W |
Beta-tubulin |
genetic |
1 |
1 |
1 |
Negative Genetic |
SPC105 |
YGL093W |
Subunit of a kinetochore-microtubule binding complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
TFG2 |
YGR005C |
TFIIF (Transcription Factor II) middle subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
UTP9 |
YHR196W |
Nucleolar protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
TAO3 |
YIL129C |
Component of the RAM signaling network |
genetic |
1 |
1 |
1 |
Negative Genetic |
SSL2 |
YIL143C |
Component of RNA polymerase transcription factor TFIIH holoenzyme |
genetic |
1 |
1 |
1 |
Negative Genetic |
TIM54 |
YJL054W |
Component of the mitochondrial TIM22 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
YKT6 |
YKL196C |
Vesicle membrane protein (v-SNARE) with acyltransferase activity |
genetic |
1 |
1 |
1 |
Negative Genetic |
STU2 |
YLR045C |
Microtubule polymerase of the XMAP215/Dis1 family |
genetic |
1 |
1 |
1 |
Negative Genetic |
RMP1 |
YLR145W |
Subunit of RNase MRP |
genetic |
1 |
1 |
1 |
Negative Genetic |
SEC22 |
YLR268W |
R-SNARE protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
RSC9 |
YML127W |
Component of the RSC chromatin remodeling complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
TIF34 |
YMR146C |
eIF3i subunit of the eukaryotic translation initiation factor 3 (eIF3) |
genetic |
1 |
1 |
1 |
Negative Genetic |
RNA1 |
YMR235C |
GTPase activating protein (GAP) for Gsp1p |
genetic |
1 |
1 |
1 |
Negative Genetic |
TOP2 |
YNL088W |
Topoisomerase II |
genetic |
1 |
1 |
1 |
Negative Genetic |
POL1 |
YNL102W |
Catalytic subunit of the DNA polymerase I alpha-primase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
RPC19 |
YNL113W |
RNA polymerase subunit AC19 |
genetic |
1 |
1 |
1 |
Negative Genetic |
PGA1 |
YNL158W |
Essential component of GPI-mannosyltransferase II |
genetic |
1 |
1 |
1 |
Negative Genetic |
SRP1 |
YNL189W |
Karyopherin alpha homolog |
genetic |
1 |
1 |
1 |
Negative Genetic |
POP3 |
YNL282W |
Subunit of both RNase MRP and nuclear RNase P |
genetic |
1 |
1 |
1 |
Negative Genetic |
RFA2 |
YNL312W |
Subunit of heterotrimeric Replication Protein A (RPA) |
genetic |
1 |
1 |
1 |
Negative Genetic |
RFC1 |
YOR217W |
Subunit of heteropentameric Replication factor C (RF-C) |
genetic |
1 |
1 |
1 |
Negative Genetic |
SOG2 |
YOR353C |
Key component of the RAM signaling network |
genetic |
1 |
1 |
1 |
Negative Genetic |
TIF6 |
YPR016C |
Constituent of 66S pre-ribosomal particles |
genetic |
1 |
1 |
1 |
Negative Genetic |
NUP192 |
YJL039C |
Essential subunit of inner ring of nuclear pore complex (NPC) |
genetic |
1 |
1 |
1 |
Negative Genetic |
VPS8 |
YAL002W |
Membrane-binding component of the CORVET complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
SPO7 |
YAL009W |
Putative regulatory subunit of Nem1p-Spo7p phosphatase holoenzyme |
genetic |
1 |
1 |
1 |
Negative Genetic |
TYR1 |
YBR166C |
Prephenate dehydrogenase involved in tyrosine biosynthesis |
genetic |
1 |
1 |
1 |
Negative Genetic |
YPC1 |
YBR183W |
Alkaline ceramidase |
genetic |
1 |
1 |
1 |
Negative Genetic |
RDI1 |
YDL135C |
Rho GDP dissociation inhibitor |
genetic |
1 |
1 |
1 |
Negative Genetic |
RGA2 |
YDR379W |
GTPase-activating protein for polarity-establishment protein Cdc42p |
genetic |
1 |
1 |
1 |
Negative Genetic |
SXM1 |
YDR395W |
Nuclear transport factor (karyopherin) |
genetic |
1 |
1 |
1 |
Negative Genetic |
SOM1 |
YEL059C-A |
Subunit of the mitochondrial inner membrane peptidase (IMP) |
genetic |
1 |
1 |
1 |
Negative Genetic |
RGD2 |
YFL047W |
GTPase-activating protein (RhoGAP) for Cdc42p and Rho5p |
genetic |
1 |
1 |
1 |
Negative Genetic |
SAP155 |
YFR040W |
Protein required for function of the Sit4p protein phosphatase |
genetic |
1 |
1 |
1 |
Negative Genetic |
YGL188C-A |
YGL188C-A |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
YGR111W |
YGR111W |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
RBG2 |
YGR173W |
Protein with a role in translation |
genetic |
1 |
1 |
1 |
Negative Genetic |
RNR4 |
YGR180C |
Ribonucleotide-diphosphate reductase (RNR) small subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
YGR240C-A |
YGR240C-A |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
RIE1 |
YGR250C |
RNA binding protein and negative regulator of START |
genetic |
1 |
1 |
1 |
Negative Genetic |
SCH9 |
YHR205W |
AGC family protein kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
YIL102C |
YIL102C |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
ZRT3 |
YKL175W |
Vacuolar membrane zinc transporter |
genetic |
1 |
1 |
1 |
Negative Genetic |
YKL183C-A |
YKL183C-A |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
YKL222C |
YKL222C |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
SHE1 |
YBL031W |
Mitotic spindle protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
UBC4 |
YBR082C |
Ubiquitin-conjugating enzyme (E2) |
genetic |
1 |
1 |
1 |
Negative Genetic |
YSA1 |
YBR111C |
Nudix hydrolase family member with ADP-ribose pyrophosphatase activity |
genetic |
1 |
1 |
1 |
Negative Genetic |
RIM1 |
YCR028C-A |
ssDNA-binding protein essential for mitochondrial genome maintenance |
genetic |
1 |
1 |
1 |
Negative Genetic |
PST1 |
YDR055W |
Cell wall protein that contains a putative GPI-attachment site |
genetic |
1 |
1 |
1 |
Negative Genetic |
TPS2 |
YDR074W |
Phosphatase subunit of the trehalose-6-P synthase/phosphatase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
RAD24 |
YER173W |
Checkpoint protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
RTF1 |
YGL244W |
Subunit of RNAPII-associated chromatin remodeling Paf1 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
RTC3 |
YHR087W |
Protein of unknown function involved in RNA metabolism |
genetic |
1 |
1 |
1 |
Negative Genetic |
RTT109 |
YLL002W |
Histone acetyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
PUS5 |
YLR165C |
Pseudouridine synthase |
genetic |
1 |
1 |
1 |
Negative Genetic |
SAS2 |
YMR127C |
Histone acetyltransferase (HAT) catalytic subunit of the SAS complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
RKR1 |
YMR247C |
RING domain E3 ubiquitin ligase |
genetic |
1 |
1 |
1 |
Negative Genetic |
YNL140C |
YNL140C |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
WHI5 |
YOR083W |
Repressor of G1 transcription |
genetic |
1 |
1 |
1 |
Negative Genetic |
PYK2 |
YOR347C |
Pyruvate kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
OAZ1 |
YPL052W |
Regulator of ornithine decarboxylase Spe1p |
genetic |
1 |
1 |
1 |
Negative Genetic |
YPT6 |
YLR262C |
Rab family GTPase |
genetic |
1 |
1 |
1 |
Negative Genetic |
VPS71 |
YML041C |
Nucleosome-binding component of the SWR1 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
URA5 |
YML106W |
Major orotate phosphoribosyltransferase (OPRTase) isozyme |
genetic |
1 |
1 |
1 |
Negative Genetic |
PSO2 |
YMR137C |
Nuclease required for DNA single- and double-strand break repair |
genetic |
1 |
1 |
1 |
Negative Genetic |
WHI3 |
YNL197C |
RNA binding protein that modulates mRNA stability |
genetic |
1 |
1 |
1 |
Negative Genetic |
SKP2 |
YNL311C |
F-box protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
TAF14 |
YPL129W |
Subunit of TFIID, TFIIF, INO80, SWI/SNF, and NuA3 complexes |
genetic |
1 |
1 |
1 |
Negative Genetic |
YPL191C |
YPL191C |
K48-specific deubiquitinating (DUB) enzyme |
genetic |
1 |
1 |
1 |
Negative Genetic |
PIN3 |
YPR154W |
Negative regulator of actin nucleation-promoting factor activity |
genetic |
1 |
1 |
1 |
Negative Genetic |
YKU80 |
YMR106C |
Subunit of telomeric Ku complex (Yku70p-Yku80p) |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
SMC1 |
YFL008W |
Subunit of the multiprotein cohesin complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
TUB4 |
YLR212C |
Gamma-tubulin |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
ARO9 |
YHR137W |
Aromatic aminotransferase II |
genetic |
1 |
1 |
1 |
Positive Genetic |
ESS1 |
YJR017C |
Peptidylprolyl-cis/trans-isomerase (PPIase) |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
ATP5 |
YDR298C |
Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase |
genetic |
1 |
1 |
1 |
Negative Genetic |
CTK3 |
YML112W |
Gamma subunit of C-terminal domain kinase I |
genetic |
1 |
1 |
1 |
Negative Genetic |
BUD27 |
YFL023W |
Unconventional prefoldin protein involved in translation initiation |
genetic |
1 |
1 |
1 |
Positive Genetic |
ARP1 |
YHR129C |
Actin-related protein of the dynactin complex |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
ATG1 |
YGL180W |
Protein serine/threonine kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
CDC43 |
YGL155W |
Beta subunit of geranylgeranyltransferase type I |
genetic |
1 |
1 |
1 |
Positive Genetic |
CSM1 |
YCR086W |
Nucleolar protein that mediates homolog segregation during meiosis I |
genetic |
1 |
1 |
1 |
Negative Genetic |
MCM16 |
YPR046W |
Component of the Ctf19 complex and the COMA subcomplex |
genetic |
1 |
1 |
1 |
Negative Genetic |
GCN4 |
YEL009C |
bZIP transcriptional activator of amino acid biosynthetic genes |
genetic |
1 |
1 |
1 |
Positive Genetic |
MOB2 |
YFL034C-B |
Activator of Cbk1p kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
MAD2 |
YJL030W |
Component of the spindle-assembly checkpoint complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
MSN5 |
YDR335W |
Karyopherin |
physical |
1 |
1 |
1 |
FRET |
COG2 |
YGR120C |
Essential component of the conserved oligomeric Golgi complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
ATG27 |
YJL178C |
Type I membrane protein involved in autophagy and the Cvt pathway |
genetic |
1 |
1 |
1 |
Negative Genetic |
CHA4 |
YLR098C |
DNA binding transcriptional activator |
genetic |
1 |
1 |
1 |
Positive Genetic |
ASK10 |
YGR097W |
Regulator of the Fps1p glycerol channel |
genetic |
1 |
1 |
1 |
Negative Genetic |
NPR2 |
YEL062W |
Subunit of the Iml1p/SEACIT complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
COG4 |
YPR105C |
Essential component of the conserved oligomeric Golgi complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
BOS1 |
YLR078C |
v-SNARE (vesicle specific SNAP receptor) |
genetic |
1 |
1 |
1 |
Negative Genetic |
CDC26 |
YFR036W |
Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) |
genetic |
1 |
1 |
1 |
Positive Genetic |
COG5 |
YNL051W |
Component of the conserved oligomeric Golgi complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
DOC1 |
YGL240W |
Processivity factor |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
NFI1 |
YOR156C |
SUMO E3 ligase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
NFI1 |
YOR156C |
SUMO E3 ligase |
genetic |
1 |
1 |
1 |
Negative Genetic |
HPC2 |
YBR215W |
Subunit of the HIR complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
CSE4 |
YKL049C |
Centromeric histone H3-like protein |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
CPT1 |
YNL130C |
Cholinephosphotransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
MOT2 |
YER068W |
Ubiquitin-protein ligase subunit of the CCR4-NOT complex |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
CLB5 |
YPR120C |
B-type cyclin involved in DNA replication during S phase |
genetic |
1 |
1 |
1 |
Negative Genetic |
CTK2 |
YJL006C |
Beta subunit of C-terminal domain kinase I (CTDK-I) |
genetic |
1 |
1 |
1 |
Negative Genetic |
BNI5 |
YNL166C |
Linker protein responsible for recruitment of myosin to the bud neck |
genetic |
1 |
1 |
1 |
Negative Genetic |
IOC2 |
YLR095C |
Subunit of the Isw1b complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
KAR3 |
YPR141C |
Minus-end-directed microtubule motor |
genetic |
1 |
1 |
1 |
Positive Genetic |
MCM3 |
YEL032W |
Protein involved in DNA replication |
genetic |
1 |
1 |
1 |
Negative Genetic |
MDM12 |
YOL009C |
Mitochondrial outer membrane protein, ERMES complex subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
MYO5 |
YMR109W |
One of two type I myosin motors |
physical |
1 |
1 |
1 |
Two-hybrid |
BET1 |
YIL004C |
Type II membrane protein required for vesicular transport |
genetic |
1 |
1 |
1 |
Negative Genetic |
MPS2 |
YGL075C |
Essential membrane protein localized at nuclear envelope and SPBs |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
CCZ1 |
YBR131W |
Subunit of a heterodimeric guanine nucleotide exchange factor (GEF) |
genetic |
1 |
1 |
1 |
Positive Genetic |
ATG2 |
YNL242W |
Peripheral membrane protein required for autophagic vesicle formation |
genetic |
1 |
1 |
1 |
Negative Genetic |
CIN1 |
YOR349W |
Tubulin folding factor D involved in beta-tubulin (Tub2p) folding |
genetic |
1 |
1 |
1 |
Negative Genetic |
CSG2 |
YBR036C |
Endoplasmic reticulum membrane protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
CDC19 |
YAL038W |
Pyruvate kinase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
MET32 |
YDR253C |
Zinc-finger DNA-binding transcription factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
BAT2 |
YJR148W |
Cytosolic branched-chain amino acid (BCAA) aminotransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
HOC1 |
YJR075W |
Alpha-1,6-mannosyltransferase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
BET4 |
YJL031C |
Alpha subunit of Type II geranylgeranyltransferase |
genetic |
1 |
1 |
1 |
Positive Genetic |
EAF6 |
YJR082C |
Subunit of the NuA4 acetyltransferase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
EAF7 |
YNL136W |
Subunit of the NuA4 histone acetyltransferase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
ASG1 |
YIL130W |
Zinc cluster protein proposed to be a transcriptional regulator |
genetic |
1 |
1 |
1 |
Positive Genetic |
GAB1 |
YLR459W |
Subunit of the glycosylphosphatidylinositol transamidase complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
MIT1 |
YEL007W |
Transcriptional regulator of pseudohyphal growth |
genetic |
1 |
1 |
1 |
Negative Genetic |
GTA1 |
YEL043W |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
HCM1 |
YCR065W |
Forkhead transcription factor |
genetic |
1 |
1 |
1 |
Positive Genetic |
GAT2 |
YMR136W |
Protein containing GATA family zinc finger motifs |
genetic |
1 |
1 |
1 |
Positive Genetic |
ERG2 |
YMR202W |
C-8 sterol isomerase |
genetic |
1 |
1 |
1 |
Negative Genetic |
NTH2 |
YBR001C |
Putative neutral trehalase, required for thermotolerance |
genetic |
1 |
1 |
1 |
Negative Genetic |
NFS1 |
YCL017C |
Cysteine desulfurase involved in iron-sulfur cluster biogenesis |
genetic |
1 |
1 |
1 |
Positive Genetic |
MCH1 |
YDL054C |
Protein with similarity to mammalian monocarboxylate permeases |
genetic |
1 |
1 |
1 |
Positive Genetic |
HRQ1 |
YDR291W |
3'-5' DNA helicase of the conserved RecQ family |
genetic |
1 |
1 |
1 |
Negative Genetic |
KCS1 |
YDR017C |
Inositol hexakisphosphate and inositol heptakisphosphate kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
MRPL17 |
YNL252C |
Mitochondrial ribosomal protein of the large subunit |
genetic |
1 |
1 |
1 |
Positive Genetic |
BRL1 |
YHR036W |
Essential nuclear envelope/ER integral membrane protein |
physical |
1 |
1 |
1 |
PCA |
NPY1 |
YGL067W |
NADH diphosphatase (pyrophosphatase) |
genetic |
1 |
1 |
1 |
Negative Genetic |
INA22 |
YIR024C |
F1F0 ATP synthase peripheral stalk assembly factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
GCD14 |
YJL125C |
Subunit of tRNA (1-methyladenosine) methyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
CTP1 |
YBR291C |
Mitochondrial inner membrane citrate transporter |
genetic |
1 |
1 |
1 |
Positive Genetic |
DTR1 |
YBR180W |
Putative dityrosine transporter of the major facilitator superfamily |
genetic |
1 |
1 |
1 |
Negative Genetic |
ELF1 |
YKL160W |
Transcription elongation factor with a conserved zinc finger domain |
genetic |
1 |
1 |
1 |
Negative Genetic |
MRPL32 |
YCR003W |
Mitochondrial ribosomal protein of the large subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
GAA1 |
YLR088W |
Subunit of the GPI:protein transamidase complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
DPH5 |
YLR172C |
Methyltransferase required for synthesis of diphthamide |
genetic |
1 |
1 |
1 |
Negative Genetic |
ARV1 |
YLR242C |
Cortical ER protein |
genetic |
1 |
1 |
1 |
Positive Genetic |
LCL1 |
YPL056C |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
EOS1 |
YNL080C |
Protein involved in N-glycosylation |
genetic |
1 |
1 |
1 |
Positive Genetic |
NCB2 |
YDR397C |
Subunit of a heterodimeric NC2 transcription regulator complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
MAM1 |
YER106W |
Monopolin |
genetic |
1 |
1 |
1 |
Negative Genetic |
ERG4 |
YGL012W |
C-24(28) sterol reductase |
genetic |
1 |
1 |
1 |
Positive Genetic |
MUP1 |
YGR055W |
High affinity methionine permease |
genetic |
1 |
1 |
1 |
Negative Genetic |
HPT1 |
YDR399W |
Dimeric hypoxanthine-guanine phosphoribosyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
GPI18 |
YBR004C |
Functional ortholog of human PIG-V |
genetic |
1 |
1 |
1 |
Negative Genetic |
CMC1 |
YKL137W |
Copper-binding protein of the mitochondrial intermembrane space |
genetic |
1 |
1 |
1 |
Negative Genetic |
MSC1 |
YML128C |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Positive Genetic |
MAL31 |
YBR298C |
Maltose permease |
genetic |
1 |
1 |
1 |
Positive Genetic |
CHM7 |
YJL049W |
Yeast homolog of human CHMP7, localizes to the endoplasmic reticulum |
genetic |
1 |
1 |
1 |
Negative Genetic |
LNP1 |
YHR192W |
Lunapark family member involved in ER network formation |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
LAS21 |
YJL062W |
Mannose-ethanolamine phosphotransferase |
genetic |
1 |
1 |
1 |
Positive Genetic |
AIM36 |
YMR157C |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
NRK1 |
YNL129W |
Nicotinamide riboside kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
LDB16 |
YCL005W |
Protein involved in lipid droplet (LD) assembly |
genetic |
1 |
1 |
1 |
Negative Genetic |
ADF1 |
YCL058W-A |
Transcriptional repressor encoded by the FYV5 antisense strand |
genetic |
1 |
1 |
1 |
Negative Genetic |