Standard name Systematic name Name description Description
SAS2 YMR127C Histone acetyltransferase (HAT) catalytic subunit of the SAS complex Histone acetyltransferase (HAT) catalytic subunit of the SAS complex; acetylates free histones and nucleosomes and regulates transcriptional silencing; member of the MYSTacetyltransferase family; other members are Sas4p and Sas5p
Visualize the interactome of SAS2
Links to external databases:
SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)
G1(P) 14

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.085 0.112 0.272
Mito 0.564 0.056 NaN
Nucleus 0.601 0.616 0.621
Vac/Vac Memb 0.070 0.264 0.053

GFP localization & abundance

GFP localization GFP abundance
cytoplasm, nucleus low signal

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
SAS2 2 0 0 0 0

Enzyme information

Catalyzed reactions in Yeast8

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
SAS4 YDR181C Subunit of the SAS complex (Sas2p, Sas4p, Sas5p) physical 12 5 6 Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Two-hybrid, Two-hybrid, Affinity Capture-MS, Co-fractionation, Affinity Capture-MS, Two-hybrid, Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex
SIR1 YKR101W Protein involved in silencing at mating-type loci HML and HMR genetic 7 3 6 Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect
SAS5 YOR213C Subunit of the SAS complex (Sas2p, Sas4p, Sas5p) physical 7 4 5 Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-MS, Co-fractionation, Affinity Capture-Western
RPD3 YNL330C Histone deacetylase, component of both the Rpd3S and Rpd3L complexes genetic 5 2 5 Negative Genetic, Synthetic Lethality, Negative Genetic, Synthetic Lethality, Negative Genetic
ORC2 YBR060C Subunit of the origin recognition complex (ORC) genetic 5 4 4 Synthetic Rescue, Synthetic Rescue, Synthetic Growth Defect, Phenotypic Enhancement, Negative Genetic
DEP1 YAL013W Component of the Rpd3L histone deacetylase complex genetic 5 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SIN3 YOL004W Component of both the Rpd3S and Rpd3L histone deacetylase complexes genetic 5 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
EAF1 YDR359C Component of the NuA4 histone acetyltransferase complex genetic 5 2 2 Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect
SDS3 YIL084C Component of the Rpd3L histone deacetylase complex genetic 4 1 2 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
LGE1 YPL055C Protein involved in histone H2B ubiquitination genetic 4 1 2 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
ESA1 YOR244W Catalytic subunit of the histone acetyltransferase complex (NuA4) genetic 4 1 1 Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect
EPL1 YFL024C Subunit of NuA4, an essential histone H4/H2A acetyltransferase complex genetic 4 1 1 Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect
YNG2 YHR090C Subunit of NuA4, an essential histone acetyltransferase complex genetic 4 1 1 Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect
SIR2 YDL042C Conserved NAD+ dependent histone deacetylase of the Sirtuin family genetic 3 3 3 Synthetic Growth Defect, Synthetic Rescue, Phenotypic Suppression
ASF1 YJL115W Nucleosome assembly factor genetic 3 2 3 Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Suppression
HHF1 YBR009C Histone H4 physical 3 2 3 Co-localization, Co-localization, Affinity Capture-MS
HHF2 YNL030W Histone H4 physical 3 2 3 Co-localization, Co-localization, Affinity Capture-MS
CDC7 YDL017W S/T kinase and catalytic subunit of DDK (Dbf4-dependent kinase) genetic 3 3 2 Negative Genetic, Phenotypic Suppression, Phenotypic Enhancement
ORC5 YNL261W Subunit of the origin recognition complex (ORC) genetic 3 3 2 Synthetic Rescue, Synthetic Growth Defect, Phenotypic Enhancement
ASF1 YJL115W Nucleosome assembly factor physical 3 2 2 Affinity Capture-Western, Affinity Capture-Western, Two-hybrid
RTF1 YGL244W Subunit of RNAPII-associated chromatin remodeling Paf1 complex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
BRE1 YDL074C E3 ubiquitin ligase genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
ACS2 YLR153C Acetyl-coA synthetase isoform genetic 3 1 2 Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect
BRE5 YNR051C Ubiquitin protease cofactor genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
TPM2 YIL138C Minor isoform of tropomyosin genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
RPL8B YLL045C Ribosomal 60S subunit protein L8A genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
HHF1 YBR009C Histone H4 genetic 2 2 2 Synthetic Rescue, Dosage Lethality
CSN9 YDR179C Subunit of the Cop9 signalosome genetic 2 2 2 Negative Genetic, Positive Genetic
CDC13 YDL220C Single stranded DNA-binding protein found at TG1-3 telomere G-tails genetic 2 2 2 Synthetic Growth Defect, Synthetic Rescue
RLF2 YPR018W Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1) genetic 2 2 2 Synthetic Growth Defect, Phenotypic Suppression
MMS1 YPR164W Subunit of E3 ubiquitin ligase complex involved in replication repair genetic 2 2 2 Positive Genetic, Phenotypic Enhancement
DPB3 YBR278W Third-largest subunit of DNA polymerase II (DNA polymerase epsilon) genetic 2 1 2 Negative Genetic, Negative Genetic
GIM4 YEL003W Subunit of the heterohexameric cochaperone prefoldin complex genetic 2 1 2 Negative Genetic, Negative Genetic
SIR3 YLR442C Silencing protein genetic 2 1 2 Synthetic Rescue, Synthetic Rescue
DOT1 YDR440W Nucleosomal histone H3-Lys79 methylase genetic 2 1 2 Phenotypic Enhancement, Phenotypic Enhancement
RLF2 YPR018W Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1) physical 2 2 1 Affinity Capture-Western, Two-hybrid
HOM3 YER052C Aspartate kinase (L-aspartate 4-P-transferase) genetic 2 1 1 Negative Genetic, Negative Genetic
RSC1 YGR056W Component of the RSC chromatin remodeling complex genetic 2 1 1 Synthetic Rescue, Synthetic Rescue
SPT20 YOL148C Subunit of the SAGA transcriptional regulatory complex genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
SPT7 YBR081C Subunit of the SAGA transcriptional regulatory complex genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
SUE1 YPR151C Protein required for degradation of unstable forms of cytochrome c genetic 2 1 1 Negative Genetic, Negative Genetic
FKH1 YIL131C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
RVB1 YDR190C ATP-dependent DNA helicase, also known as pontin physical 1 1 1 Affinity Capture-MS
HSP60 YLR259C Tetradecameric mitochondrial chaperonin physical 1 1 1 Affinity Capture-MS
RPL10 YLR075W Ribosomal 60S subunit protein L10 physical 1 1 1 Affinity Capture-MS
PLB1 YMR008C Phospholipase B (lysophospholipase) involved in lipid metabolism physical 1 1 1 Affinity Capture-MS
KAP123 YER110C Karyopherin beta physical 1 1 1 Affinity Capture-Western
RAT1 YOR048C Nuclear 5' to 3' single-stranded RNA exonuclease genetic 1 1 1 Negative Genetic
CDC48 YDL126C AAA ATPase with protein-unfoldase activity genetic 1 1 1 Positive Genetic
CBC2 YPL178W Small subunit of the heterodimeric cap binding complex with Sto1p genetic 1 1 1 Negative Genetic
DST1 YGL043W General transcription elongation factor TFIIS genetic 1 1 1 Synthetic Lethality
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
NAM7 YMR080C ATP-dependent RNA helicase of the SFI superfamily physical 1 1 1 Affinity Capture-RNA
ABD1 YBR236C Methyltransferase genetic 1 1 1 Positive Genetic
ARP3 YJR065C Essential component of the Arp2/3 complex genetic 1 1 1 Positive Genetic
BMH2 YDR099W 14-3-3 protein, minor isoform physical 1 1 1 Affinity Capture-MS
COX6 YHR051W Subunit VI of cytochrome c oxidase (Complex IV) genetic 1 1 1 Negative Genetic
ECM5 YMR176W Subunit of the Snt2C complex genetic 1 1 1 Negative Genetic
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
HRP1 YOL123W Subunit of cleavage factor I genetic 1 1 1 Negative Genetic
CRM1 YGR218W Nuclear export factor, exportin physical 1 1 1 Affinity Capture-MS
IMG1 YCR046C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
MEC1 YBR136W Genome integrity checkpoint protein and PI kinase superfamily member genetic 1 1 1 Negative Genetic
HTZ1 YOL012C Histone variant H2AZ physical 1 1 1 Co-localization
HTZ1 YOL012C Histone variant H2AZ genetic 1 1 1 Synthetic Growth Defect
GIM5 YML094W Subunit of the heterohexameric cochaperone prefoldin complex genetic 1 1 1 Synthetic Growth Defect
PSE1 YMR308C Karyopherin/importin that interacts with the nuclear pore complex physical 1 1 1 Affinity Capture-Western
MKT1 YNL085W Protein similar to nucleases that forms a complex with Pbp1p physical 1 1 1 Affinity Capture-MS
RET2 YFR051C Delta subunit of the coatomer complex (COPI) genetic 1 1 1 Positive Genetic
MRPL6 YHR147C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
PHO23 YNL097C Component of the Rpd3L histone deacetylase complex genetic 1 1 1 Negative Genetic
PPH21 YDL134C Catalytic subunit of protein phosphatase 2A, PP2A genetic 1 1 1 Negative Genetic
NUP84 YDL116W Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) genetic 1 1 1 Positive Genetic
SAP30 YMR263W Component of Rpd3L histone deacetylase complex genetic 1 1 1 Negative Genetic
LSB3 YFR024C-A Protein containing a C-terminal SH3 domain physical 1 1 1 Affinity Capture-MS
CCT8 YJL008C Subunit of the cytosolic chaperonin Cct ring complex genetic 1 1 1 Negative Genetic
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes genetic 1 1 1 Phenotypic Enhancement
ROM2 YLR371W Guanine nucleotide exchange factor (GEF) for Rho1p and Rho2p genetic 1 1 1 Negative Genetic
NEW1 YPL226W Translation termination and ribosome biogenesis factor genetic 1 1 1 Positive Genetic
PUF3 YLL013C Protein of the mitochondrial outer surface physical 1 1 1 Affinity Capture-RNA
MMS2 YGL087C Ubiquitin-conjugating enzyme variant genetic 1 1 1 Phenotypic Enhancement
PMA1 YGL008C Plasma membrane P2-type H+-ATPase physical 1 1 1 Affinity Capture-MS
FUM1 YPL262W Fumarase genetic 1 1 1 Negative Genetic
RAD6 YGL058W Ubiquitin-conjugating enzyme (E2) genetic 1 1 1 Negative Genetic
HIR1 YBL008W Subunit of the HIR complex genetic 1 1 1 Synthetic Growth Defect
HHT1 YBR010W Histone H3 genetic 1 1 1 Synthetic Rescue
CTF4 YPR135W Chromatin-associated protein genetic 1 1 1 Negative Genetic
BUB3 YOR026W Kinetochore checkpoint WD40 repeat protein genetic 1 1 1 Negative Genetic
NUP133 YKR082W Subunit of Nup84p subcomplex of nuclear pore complex (NPC) genetic 1 1 1 Negative Genetic
HST3 YOR025W Sirtuin, histone H3 deacetylase genetic 1 1 1 Synthetic Rescue
GCN4 YEL009C bZIP transcriptional activator of amino acid biosynthetic genes genetic 1 1 1 Positive Genetic
PEX21 YGR239C Peroxin required for peroxisomal matrix protein targeting genetic 1 1 1 Negative Genetic
PKC1 YBL105C Protein serine/threonine kinase genetic 1 1 1 Negative Genetic
COQ5 YML110C 2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase genetic 1 1 1 Negative Genetic
APC5 YOR249C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 1 1 1 Synthetic Rescue
ELP3 YPL086C Subunit of Elongator complex genetic 1 1 1 Negative Genetic
DAL81 YIR023W Positive regulator of genes in multiple nitrogen degradation pathways genetic 1 1 1 Negative Genetic
CSE4 YKL049C Centromeric histone H3-like protein genetic 1 1 1 Dosage Lethality
RIF1 YBR275C Protein involved in control of DNA replication genetic 1 1 1 Negative Genetic
CTF8 YHR191C Subunit of a complex with Ctf18p genetic 1 1 1 Positive Genetic
PAN1 YIR006C Part of actin cytoskeleton-regulatory complex Pan1p-Sla1p-End3p genetic 1 1 1 Positive Genetic
RRN3 YKL125W Protein required for transcription of rDNA by RNA polymerase I genetic 1 1 1 Negative Genetic
SAS2 YMR127C Histone acetyltransferase (HAT) catalytic subunit of the SAS complex physical 1 1 1 Two-hybrid
TAF10 YDR167W Subunit (145 kDa) of TFIID and SAGA complexes physical 1 1 1 Affinity Capture-MS
TAF6 YGL112C Subunit (60 kDa) of TFIID and SAGA complexes physical 1 1 1 Affinity Capture-MS
SSN8 YNL025C Cyclin-like component of RNA polymerase II holoenzyme genetic 1 1 1 Negative Genetic
TAF12 YDR145W Subunit (61/68 kDa) of TFIID and SAGA complexes genetic 1 1 1 Negative Genetic
YKE2 YLR200W Subunit of the heterohexameric Gim/prefoldin protein complex genetic 1 1 1 Negative Genetic
YML119W YML119W Putative protein of unknown function genetic 1 1 1 Positive Genetic
VID22 YLR373C G-quadruplex (G4) DNA binding protein genetic 1 1 1 Positive Genetic
YBL086C YBL086C Protein of unknown function genetic 1 1 1 Positive Genetic
SIR4 YDR227W SIR protein involved in assembly of silent chromatin domains genetic 1 1 1 Synthetic Rescue
YGL081W YGL081W Putative protein of unknown function genetic 1 1 1 Negative Genetic
SIN4 YNL236W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Positive Genetic
SCM3 YDL139C Nonhistone component of centromeric chromatin genetic 1 1 1 Dosage Rescue
TAF1 YGR274C TFIID subunit, involved in RNA pol II transcription initiation genetic 1 1 1 Synthetic Lethality
SEC7 YDR170C Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors genetic 1 1 1 Positive Genetic
YJU2 YKL095W Essential protein required for pre-mRNA splicing genetic 1 1 1 Positive Genetic
SGF29 YCL010C Component of the HAT/Core module of the SAGA, SLIK, and ADA complexes genetic 1 1 1 Positive Genetic
TIM22 YDL217C Essential core component of mitochondrial TIM22 complex genetic 1 1 1 Negative Genetic
TFB1 YDR311W Subunit of TFIIH and nucleotide excision repair factor 3 complexes genetic 1 1 1 Negative Genetic
YEA4 YEL004W Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter genetic 1 1 1 Negative Genetic
TIM21 YGR033C Nonessential component of the TIM23 complex genetic 1 1 1 Negative Genetic
SFB3 YHR098C Component of the Sec23p-Sfb3p heterodimer of the COPII vesicle coat genetic 1 1 1 Negative Genetic
YJR011C YJR011C Putative protein of unknown function genetic 1 1 1 Negative Genetic
VPS55 YJR044C Late endosomal protein involved in late endosome to vacuole transport genetic 1 1 1 Negative Genetic
SKG1 YKR100C Transmembrane protein with a role in cell wall polymer composition genetic 1 1 1 Negative Genetic
ZIP1 YDR285W Transverse filament protein of the synaptonemal complex genetic 1 1 1 Phenotypic Suppression
SMA2 YML066C Meiosis-specific prospore membrane protein genetic 1 1 1 Negative Genetic
STE50 YCL032W Adaptor protein for various signaling pathways genetic 1 1 1 Negative Genetic
YDL157C YDL157C Putative protein of unknown function genetic 1 1 1 Negative Genetic
UME6 YDR207C Rpd3L histone deacetylase complex subunit genetic 1 1 1 Negative Genetic
URE2 YNL229C Nitrogen catabolite repression transcriptional regulator genetic 1 1 1 Negative Genetic
SLA2 YNL243W Adaptor protein that links actin to clathrin and endocytosis genetic 1 1 1 Negative Genetic
VMA13 YPR036W Subunit H of the V1 peripheral membrane domain of V-ATPase genetic 1 1 1 Negative Genetic
SMC1 YFL008W Subunit of the multiprotein cohesin complex genetic 1 1 1 Negative Genetic
SWC4 YGR002C Component of the Swr1p complex that incorporates Htz1p into chromatin genetic 1 1 1 Negative Genetic
YKU70 YMR284W Subunit of the telomeric Ku complex (Yku70p-Yku80p) genetic 1 1 1 Synthetic Rescue
MGM1 YOR211C Mitochondrial GTPase, present in complex with Ugo1p and Fzo1p genetic 1 1 1 Negative Genetic
MCM7 YBR202W Component of the Mcm2-7 hexameric helicase complex genetic 1 1 1 Negative Genetic
GPR1 YDL035C Plasma membrane G protein coupled receptor (GPCR) genetic 1 1 1 Negative Genetic
CBS2 YDR197W Mitochondrial translational activator of the COB mRNA genetic 1 1 1 Negative Genetic
DSF2 YBR007C Deletion suppressor of mpt5 mutation physical 1 1 1 Affinity Capture-MS
GAS5 YOL030W 1,3-beta-glucanosyltransferase physical 1 1 1 Affinity Capture-MS
RAD30 YDR419W DNA polymerase eta genetic 1 1 1 Negative Genetic
RTT101 YJL047C Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex genetic 1 1 1 Phenotypic Enhancement
RTT109 YLL002W Histone acetyltransferase genetic 1 1 1 Phenotypic Suppression
RIA1 YNL163C Cytoplasmic GTPase/eEF2-like factor involved in ribosomal biogenesis genetic 1 1 1 Positive Genetic
COQ6 YGR255C Flavin-dependent monooxygenase involved in ubiquinone biosynthesis genetic 1 1 1 Negative Genetic
PRI2 YKL045W Subunit of DNA primase genetic 1 1 1 Negative Genetic
EMA35 YCR100C Protein involved in protein sorting genetic 1 1 1 Negative Genetic
HST4 YDR191W NAD(+)-dependent protein deacetylase genetic 1 1 1 Synthetic Rescue
NCB2 YDR397C Subunit of a heterodimeric NC2 transcription regulator complex genetic 1 1 1 Negative Genetic
ALG14 YBR070C Component of UDP-GlcNAc transferase genetic 1 1 1 Negative Genetic
PFD1 YJL179W Subunit of heterohexameric prefoldin genetic 1 1 1 Negative Genetic
IFM1 YOL023W Mitochondrial translation initiation factor 2 genetic 1 1 1 Negative Genetic
MSC1 YML128C Protein of unknown function genetic 1 1 1 Negative Genetic
GLD1 YPR109W Component of Dsc E3 ligase complex in Golgi and endosomes genetic 1 1 1 Negative Genetic
ROF1 YHR177W Putative transcription factor containing a WOPR domain genetic 1 1 1 Positive Genetic