Standard name Systematic name Name description Description
TAF1 YGR274C TFIID subunit, involved in RNA pol II transcription initiation TFIID subunit, involved in RNA pol II transcription initiation; possesses in vitro histone acetyltransferase activity but its role in vivo appears to be minor; involved in promoter binding and G1/S progression; relocalizes to the cytosol in response to hypoxia
Visualize the interactome of TAF1
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Nucleolus 0.173 0.179 0.175
Nucleus 0.907 0.907 0.912
Mito NaN 0.116 0.561

GFP localization & abundance

GFP localization GFP abundance
nucleus 1500

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
TAF1 7 0 0 0 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
SPT15 YER148W TATA-binding protein (TBP) physical 44 8 31 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western, Co-purification, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Co-localization, Affinity Capture-Western, Protein-peptide, Affinity Capture-Western, Affinity Capture-Western, Co-crystal Structure, Two-hybrid, Reconstituted Complex, Reconstituted Complex, Affinity Capture-MS
TAF6 YGL112C Subunit (60 kDa) of TFIID and SAGA complexes physical 24 6 19 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Two-hybrid, Two-hybrid, Reconstituted Complex, Co-purification, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Co-localization, Affinity Capture-Western, Co-purification, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western
TAF5 YBR198C Subunit (90 kDa) of TFIID and SAGA complexes physical 22 3 15 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Co-purification, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Co-purification, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS
TAF12 YDR145W Subunit (61/68 kDa) of TFIID and SAGA complexes physical 19 4 16 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western, Co-purification, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Co-purification, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS
TAF9 YMR236W Subunit (17 kDa) of TFIID and SAGA complexes physical 18 4 15 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Co-purification, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Co-localization, Affinity Capture-Western, Co-purification, Affinity Capture-Western, Co-localization, Affinity Capture-MS, Affinity Capture-MS
TAF3 YPL011C TFIID subunit (47 kDa) physical 18 4 15 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Co-purification, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Co-purification, Affinity Capture-Western, Co-localization, Affinity Capture-MS
TAF10 YDR167W Subunit (145 kDa) of TFIID and SAGA complexes physical 18 4 15 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Co-purification, Affinity Capture-MS, Affinity Capture-Western, Co-localization, Affinity Capture-Western, Co-purification, Affinity Capture-Western
TAF4 YMR005W TFIID subunit (48 kDa) physical 18 6 13 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Two-hybrid, Reconstituted Complex, Co-purification, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Co-localization, Affinity Capture-Western, Co-purification, Affinity Capture-Western, Affinity Capture-Western
TAF11 YML015C TFIID subunit (40 kDa) physical 16 3 13 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Co-purification, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Co-purification, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS
TAF8 YML114C TFIID subunit (65 kDa) physical 14 4 11 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Co-purification, Affinity Capture-MS, Affinity Capture-Western, Co-localization, Affinity Capture-Western, Co-purification, Affinity Capture-Western, Co-localization
TAF14 YPL129W Subunit of TFIID, TFIIF, INO80, SWI/SNF, and NuA3 complexes physical 13 4 11 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Co-purification, Affinity Capture-Western, Co-purification, Affinity Capture-Western, Co-localization, Affinity Capture-Western, Affinity Capture-MS
TAF2 YCR042C TFIID subunit (150 kDa) physical 13 3 10 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Co-purification, Affinity Capture-MS, Affinity Capture-Western, Co-purification, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS
TAF13 YML098W TFIID subunit (19 kDa) physical 12 4 10 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Co-purification, Affinity Capture-MS, Affinity Capture-Western, Co-purification, Affinity Capture-Western, Co-localization
TAF7 YMR227C TFIID subunit (67 kDa) physical 12 4 10 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Co-purification, Affinity Capture-MS, Co-localization, Affinity Capture-Western, Co-purification, Affinity Capture-Western, Co-localization, Affinity Capture-MS
VPS72 YDR485C Htz1p-binding component of the SWR1 complex genetic 6 2 4 Negative Genetic, Negative Genetic, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic
LSM1 YJL124C Lsm (Like Sm) protein genetic 5 3 4 Negative Genetic, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Positive Genetic
TAF12 YDR145W Subunit (61/68 kDa) of TFIID and SAGA complexes genetic 5 2 3 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic
SPT15 YER148W TATA-binding protein (TBP) genetic 4 3 4 Dosage Rescue, Synthetic Lethality, Synthetic Lethality, Negative Genetic
HRQ1 YDR291W 3'-5' DNA helicase of the conserved RecQ family genetic 4 3 3 Synthetic Lethality, Negative Genetic, Positive Genetic, Negative Genetic
ACT1 YFL039C Actin, structural protein in cytoskeleton genetic 4 2 2 Synthetic Haploinsufficiency, Synthetic Haploinsufficiency, Negative Genetic, Negative Genetic
VPS71 YML041C Nucleosome-binding component of the SWR1 complex genetic 4 2 2 Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic
SWC3 YAL011W Protein of unknown function genetic 4 2 2 Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic
CDC39 YCR093W Subunit of the CCR4-NOT1 core complex physical 4 3 1 Affinity Capture-Western, Affinity Capture-Western, Two-hybrid, Co-purification
ASF1 YJL115W Nucleosome assembly factor genetic 3 3 3 Dosage Rescue, Negative Genetic, Synthetic Lethality
PAT1 YCR077C Deadenylation-dependent mRNA-decapping factor genetic 3 2 3 Negative Genetic, Negative Genetic, Positive Genetic
ADA2 YDR448W Transcription coactivator physical 3 2 3 Affinity Capture-MS, Reconstituted Complex, Affinity Capture-MS
SLA1 YBL007C Cytoskeletal protein binding protein genetic 3 2 3 Negative Genetic, Synthetic Lethality, Negative Genetic
SPT3 YDR392W Subunit of the SAGA and SAGA-like transcriptional regulatory complexes genetic 3 2 3 Synthetic Growth Defect, Negative Genetic, Negative Genetic
PSF1 YDR013W Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) genetic 3 2 2 Synthetic Lethality, Negative Genetic, Negative Genetic
LSM6 YDR378C Lsm (Like Sm) protein genetic 3 2 2 Synthetic Lethality, Synthetic Lethality, Negative Genetic
LSM7 YNL147W Lsm (Like Sm) protein genetic 3 2 2 Synthetic Lethality, Synthetic Lethality, Negative Genetic
TAF8 YML114C TFIID subunit (65 kDa) genetic 3 2 2 Synthetic Lethality, Synthetic Lethality, Negative Genetic
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 3 2 2 Negative Genetic, Positive Genetic, Negative Genetic
BUB3 YOR026W Kinetochore checkpoint WD40 repeat protein genetic 3 2 2 Synthetic Lethality, Synthetic Lethality, Negative Genetic
MOB2 YFL034C-B Activator of Cbk1p kinase genetic 3 2 2 Synthetic Lethality, Negative Genetic, Negative Genetic
SSN2 YDR443C Subunit of the RNA polymerase II mediator complex genetic 3 2 2 Synthetic Lethality, Synthetic Lethality, Negative Genetic
SWR1 YDR334W Swi2/Snf2-related ATPase genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
HMO1 YDR174W Chromatin associated high mobility group (HMG) family member genetic 3 3 1 Dosage Lethality, Synthetic Growth Defect, Phenotypic Enhancement
NOT5 YPR072W Component of the CCR4-NOT core complex, involved in mRNA decapping genetic 3 3 1 Dosage Lethality, Synthetic Lethality, Synthetic Rescue
MOT2 YER068W Ubiquitin-protein ligase subunit of the CCR4-NOT complex genetic 3 3 1 Dosage Lethality, Synthetic Lethality, Synthetic Rescue
BUB1 YGR188C Protein kinase involved in the cell cycle checkpoint into anaphase genetic 3 1 1 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality
CKB2 YOR039W Beta' regulatory subunit of casein kinase 2 (CK2) genetic 2 2 2 Synthetic Lethality, Negative Genetic
BMH1 YER177W 14-3-3 protein, major isoform genetic 2 2 2 Synthetic Lethality, Negative Genetic
RPS4B YHR203C Protein component of the small (40S) ribosomal subunit genetic 2 2 2 Synthetic Lethality, Negative Genetic
BEM1 YBR200W Protein containing SH3-domains genetic 2 2 2 Negative Genetic, Synthetic Lethality
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit genetic 2 2 2 Synthetic Lethality, Dosage Lethality
CTK1 YKL139W Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I) genetic 2 2 2 Negative Genetic, Synthetic Lethality
ISW1 YBR245C ATPase subunit of imitation-switch (ISWI) class chromatin remodelers physical 2 2 2 Affinity Capture-MS, Affinity Capture-RNA
MCM5 YLR274W Component of the Mcm2-7 hexameric helicase complex genetic 2 2 2 Synthetic Lethality, Negative Genetic
IES5 YER092W Non-essential INO80 chromatin remodeling complex subunit genetic 2 2 2 Synthetic Lethality, Negative Genetic
LEA1 YPL213W Component of U2 snRNP complex genetic 2 2 2 Negative Genetic, Positive Genetic
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes genetic 2 2 2 Synthetic Growth Defect, Synthetic Lethality
SUA7 YPR086W Transcription factor TFIIB physical 2 2 2 Affinity Capture-MS, Co-localization
TAF11 YML015C TFIID subunit (40 kDa) genetic 2 2 2 Synthetic Lethality, Negative Genetic
TAF6 YGL112C Subunit (60 kDa) of TFIID and SAGA complexes genetic 2 2 2 Synthetic Lethality, Negative Genetic
TAF10 YDR167W Subunit (145 kDa) of TFIID and SAGA complexes genetic 2 2 2 Synthetic Lethality, Negative Genetic
TOA1 YOR194C TFIIA large subunit genetic 2 2 2 Dosage Rescue, Negative Genetic
VMS1 YDR049W Peptidyl-tRNA hydrolase that releases stalled peptides from ribosomes, genetic 2 2 2 Synthetic Lethality, Negative Genetic
YKE2 YLR200W Subunit of the heterohexameric Gim/prefoldin protein complex genetic 2 2 2 Synthetic Lethality, Negative Genetic
TGS1 YPL157W Trimethyl guanosine synthase, conserved nucleolar methyl transferase genetic 2 2 2 Synthetic Lethality, Positive Genetic
YPR159C-A YPR159C-A Protein of unknown function genetic 2 2 2 Synthetic Lethality, Negative Genetic
ADR1 YDR216W Carbon source-responsive zinc-finger transcription factor physical 2 2 2 Affinity Capture-Western, Reconstituted Complex
CDC20 YGL116W Activator of anaphase-promoting complex/cyclosome (APC/C) genetic 2 2 2 Synthetic Lethality, Positive Genetic
KAP122 YGL016W Karyopherin beta genetic 2 2 2 Synthetic Lethality, Negative Genetic
DIA2 YOR080W Origin-binding F-box protein genetic 2 2 2 Synthetic Lethality, Negative Genetic
SLT2 YHR030C Serine/threonine MAP kinase genetic 2 2 2 Synthetic Lethality, Dosage Growth Defect
HST3 YOR025W Sirtuin, histone H3 deacetylase genetic 2 2 2 Synthetic Lethality, Negative Genetic
OCA2 YNL056W Protein of unknown function genetic 2 2 2 Synthetic Lethality, Negative Genetic
HPC2 YBR215W Subunit of the HIR complex genetic 2 2 2 Synthetic Lethality, Negative Genetic
FRQ1 YDR373W N-myristoylated calcium-binding protein genetic 2 2 2 Synthetic Lethality, Negative Genetic
RPL11B YGR085C Ribosomal 60S subunit protein L11B genetic 2 2 2 Synthetic Lethality, Negative Genetic
STB5 YHR178W Transcription factor genetic 2 2 2 Synthetic Lethality, Negative Genetic
SEC39 YLR440C Component of the Dsl1p tethering complex genetic 2 2 2 Synthetic Lethality, Negative Genetic
MRC1 YCL061C S-phase checkpoint protein required for DNA replication genetic 2 2 2 Synthetic Lethality, Negative Genetic
SAC1 YKL212W Phosphatidylinositol phosphate phosphatase genetic 2 2 2 Synthetic Lethality, Positive Genetic
RPP1B YDL130W Ribosomal protein P1 beta genetic 2 2 2 Synthetic Lethality, Negative Genetic
SSF1 YHR066W Constituent of 66S pre-ribosomal particles genetic 2 1 2 Negative Genetic, Negative Genetic
SIN4 YNL236W Subunit of the RNA polymerase II mediator complex physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
REB1 YBR049C RNA polymerase I enhancer binding protein physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
HHF1 YBR009C Histone H4 physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
MED1 YPR070W Subunit of the RNA polymerase II mediator complex genetic 2 1 2 Negative Genetic, Negative Genetic
MYO1 YHR023W Type II myosin heavy chain physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
POP2 YNR052C Subunit of Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
ROM2 YLR371W Guanine nucleotide exchange factor (GEF) for Rho1p and Rho2p genetic 2 1 2 Negative Genetic, Negative Genetic
VPS1 YKR001C Dynamin-like GTPase required for vacuolar sorting physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
TAF1 YGR274C TFIID subunit, involved in RNA pol II transcription initiation physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
UBP3 YER151C Ubiquitin-specific protease that cleaves Ub-protein fusions genetic 2 1 2 Negative Genetic, Negative Genetic
VAM3 YOR106W Syntaxin-like vacuolar t-SNARE genetic 2 1 2 Negative Genetic, Negative Genetic
URC2 YDR520C Putative Zn(II)2Cys6 motif containing transcription factor genetic 2 1 2 Negative Genetic, Negative Genetic
TPH3 YJL016W Putative protein of unknown function genetic 2 1 2 Positive Genetic, Positive Genetic
ZRT3 YKL175W Vacuolar membrane zinc transporter genetic 2 1 2 Negative Genetic, Negative Genetic
VRP1 YLR337C Verprolin, proline-rich actin-associated protein genetic 2 1 2 Negative Genetic, Negative Genetic
VIP1 YLR410W Bifunctional inositol pyrophosphate kinase and phosphatase genetic 2 1 2 Negative Genetic, Negative Genetic
PUF3 YLL013C Protein of the mitochondrial outer surface physical 2 1 2 Affinity Capture-RNA, Affinity Capture-RNA
RPS26B YER131W Protein component of the small (40S) ribosomal subunit genetic 2 1 2 Negative Genetic, Negative Genetic
AIM4 YBR194W Protein proposed to be associated with the nuclear pore complex genetic 2 1 2 Negative Genetic, Negative Genetic
CST6 YIL036W Basic leucine zipper (bZIP) transcription factor from ATF/CREB family genetic 2 1 2 Negative Genetic, Negative Genetic
ARP6 YLR085C Actin-related protein that binds nucleosomes genetic 2 1 2 Negative Genetic, Negative Genetic
SRN2 YLR119W Component of the ESCRT-I complex genetic 2 1 2 Negative Genetic, Negative Genetic
MPT5 YGL178W mRNA-binding protein of the PUF family physical 2 1 2 Affinity Capture-RNA, Affinity Capture-RNA
GYP1 YOR070C Cis-golgi GTPase-activating protein (GAP) for yeast Rabs genetic 2 1 2 Negative Genetic, Negative Genetic
STE50 YCL032W Adaptor protein for various signaling pathways genetic 2 1 2 Negative Genetic, Negative Genetic
RPS3 YNL178W Protein component of the small (40S) ribosomal subunit physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
SOH1 YGL127C Subunit of the RNA polymerase II mediator complex genetic 2 1 2 Negative Genetic, Negative Genetic
BTS1 YPL069C Geranylgeranyl diphosphate synthase (GGPPS) genetic 2 1 2 Negative Genetic, Negative Genetic
COQ11 YLR290C Putative oxidoreductase, subunit of Coenzyme Q biosynthetic complexes genetic 2 1 2 Negative Genetic, Negative Genetic
PKR1 YMR123W V-ATPase assembly factor genetic 2 1 2 Negative Genetic, Negative Genetic
COX10 YPL172C Heme A:farnesyltransferase genetic 2 1 2 Negative Genetic, Negative Genetic
HMO1 YDR174W Chromatin associated high mobility group (HMG) family member physical 2 2 1 Two-hybrid, Affinity Capture-Western
CDC45 YLR103C DNA replication initiation factor genetic 2 1 1 Negative Genetic, Negative Genetic
PRP18 YGR006W Splicing factor and component of snRNP U5 genetic 2 1 1 Negative Genetic, Negative Genetic
TAF9 YMR236W Subunit (17 kDa) of TFIID and SAGA complexes genetic 2 1 1 Negative Genetic, Negative Genetic
TAF13 YML098W TFIID subunit (19 kDa) genetic 2 1 1 Negative Genetic, Negative Genetic
TAF7 YMR227C TFIID subunit (67 kDa) genetic 2 1 1 Negative Genetic, Negative Genetic
CDC37 YDR168W Essential Hsp90p co-chaperone genetic 2 1 1 Negative Genetic, Negative Genetic
DPB11 YJL090C DNA replication initiation protein genetic 2 1 1 Negative Genetic, Negative Genetic
CDC7 YDL017W S/T kinase and catalytic subunit of DDK (Dbf4-dependent kinase) genetic 2 1 1 Negative Genetic, Negative Genetic
SMT3 YDR510W Ubiquitin-like protein of the SUMO family genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
HSP10 YOR020C Mitochondrial matrix co-chaperonin genetic 2 1 1 Negative Genetic, Negative Genetic
IBD2 YNL164C Component of the BUB2-dependent spindle checkpoint pathway genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
DBF4 YDR052C Regulatory subunit of Cdc7p-Dbf4p kinase complex genetic 2 1 1 Negative Genetic, Negative Genetic
SPC42 YKL042W Central plaque component of spindle pole body (SPB) genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
PFY1 YOR122C Profilin genetic 2 1 1 Negative Genetic, Negative Genetic
SLI15 YBR156C Subunit of the conserved chromosomal passenger complex (CPC) genetic 2 1 1 Negative Genetic, Negative Genetic
CHM7 YJL049W Yeast homolog of human CHMP7, localizes to the endoplasmic reticulum physical 2 1 1 Two-hybrid, Two-hybrid
FKH1 YIL131C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SFP1 YLR403W Regulates transcription of ribosomal protein and biogenesis genes regulation 1 1 1 DNA to cDNA expression microarray evidence
MED4 YOR174W Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CTR9 YOL145C Component of the Paf1p complex involved in transcription elongation physical 1 1 1 Two-hybrid
CHL4 YDR254W Outer kinetochore protein required for chromosome stability genetic 1 1 1 Synthetic Lethality
CTF3 YLR381W Outer kinetochore protein that forms a complex with Mcm16p and Mcm22p genetic 1 1 1 Synthetic Lethality
MTW1 YAL034W-A Essential component of the MIND kinetochore complex genetic 1 1 1 Negative Genetic
NKP1 YDR383C Central kinetochore protein and subunit of the Ctf19 complex genetic 1 1 1 Synthetic Lethality
NSL1 YPL233W Essential component of the MIND kinetochore complex genetic 1 1 1 Negative Genetic
PSF2 YJL072C Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) genetic 1 1 1 Negative Genetic
RPO21 YDL140C RNA polymerase II largest subunit B220 physical 1 1 1 Co-localization
CKA1 YIL035C Alpha catalytic subunit of casein kinase 2 (CK2) genetic 1 1 1 Synthetic Lethality
CKB1 YGL019W Beta regulatory subunit of casein kinase 2 (CK2) genetic 1 1 1 Synthetic Lethality
NSE3 YDR288W Component of the SMC5-SMC6 complex genetic 1 1 1 Negative Genetic
ARP4 YJL081C Nuclear actin-related protein involved in chromatin remodeling genetic 1 1 1 Negative Genetic
RVB2 YPL235W ATP-dependent DNA helicase, also known as reptin physical 1 1 1 Affinity Capture-MS
SWC4 YGR002C Component of the Swr1p complex that incorporates Htz1p into chromatin genetic 1 1 1 Negative Genetic
EAF1 YDR359C Component of the NuA4 histone acetyltransferase complex genetic 1 1 1 Phenotypic Suppression
EBP2 YKL172W Required for 25S rRNA maturation and 60S ribosomal subunit assembly physical 1 1 1 Two-hybrid
NOP2 YNL061W rRNA m5C methyltransferase physical 1 1 1 Two-hybrid
IMH1 YLR309C Protein involved in vesicular transport physical 1 1 1 Two-hybrid
POP3 YNL282W Subunit of both RNase MRP and nuclear RNase P genetic 1 1 1 Positive Genetic
RMP1 YLR145W Subunit of RNase MRP genetic 1 1 1 Synthetic Lethality
SNU114 YKL173W GTPase component of U5 snRNP involved in mRNA splicing via spliceosome genetic 1 1 1 Synthetic Lethality
BRE1 YDL074C E3 ubiquitin ligase genetic 1 1 1 Synthetic Lethality
ARL1 YBR164C Soluble GTPase with a role in regulation of membrane traffic genetic 1 1 1 Synthetic Lethality
KES1 YPL145C Sterol/phosphatidylinositol-4-phosphate (PI(4)P) exchanger genetic 1 1 1 Synthetic Lethality
MDM20 YOL076W Non-catalytic subunit of the NatB N-terminal acetyltransferase genetic 1 1 1 Synthetic Lethality
SAP155 YFR040W Protein required for function of the Sit4p protein phosphatase genetic 1 1 1 Synthetic Lethality
SAP190 YKR028W Protein that forms a complex with the Sit4p protein phosphatase genetic 1 1 1 Synthetic Lethality
NOP1 YDL014W Histone glutamine methyltransferase, modifies H2A at Q105 in nucleolus physical 1 1 1 Affinity Capture-MS
NOP1 YDL014W Histone glutamine methyltransferase, modifies H2A at Q105 in nucleolus genetic 1 1 1 Synthetic Lethality
DIS3 YOL021C Exosome core complex catalytic subunit genetic 1 1 1 Synthetic Lethality
LRP1 YHR081W Nuclear exosome-associated nucleic acid binding protein genetic 1 1 1 Negative Genetic
RRP4 YHR069C Exosome non-catalytic core component genetic 1 1 1 Synthetic Lethality
RPC82 YPR190C RNA polymerase III subunit C82 physical 1 1 1 Affinity Capture-MS
RPA190 YOR341W RNA polymerase I largest subunit A190 genetic 1 1 1 Synthetic Lethality
MFT1 YML062C Subunit of the THO complex genetic 1 1 1 Synthetic Lethality
GCD11 YER025W Gamma subunit of the translation initiation factor eIF2 genetic 1 1 1 Synthetic Lethality
ARP7 YPR034W Component of both the SWI/SNF and RSC chromatin remodeling complexes genetic 1 1 1 Negative Genetic
RSC3 YDR303C Component of the RSC chromatin remodeling complex genetic 1 1 1 Synthetic Lethality
RSC4 YKR008W Component of the RSC chromatin remodeling complex genetic 1 1 1 Synthetic Lethality
RTT102 YGR275W Component of both the SWI/SNF and RSC chromatin remodeling complexes genetic 1 1 1 Synthetic Lethality
MED4 YOR174W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
NUT1 YGL151W Component of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
RGR1 YLR071C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
SRB5 YGR104C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Synthetic Lethality
SNU56 YDR240C Component of U1 snRNP required for mRNA splicing via spliceosome genetic 1 1 1 Negative Genetic
DST1 YGL043W General transcription elongation factor TFIIS genetic 1 1 1 Synthetic Lethality
NAP1 YKR048C Histone chaperone and assembly chaperone for Rps6a/b genetic 1 1 1 Synthetic Lethality
REI1 YBR267W Cytoplasmic pre-60S factor genetic 1 1 1 Negative Genetic
RPN5 YDL147W Subunit of the CSN and 26S proteasome lid complexes genetic 1 1 1 Negative Genetic
RPN3 YER021W Essential non-ATPase regulatory subunit of the 26S proteasome lid genetic 1 1 1 Synthetic Lethality
HCR1 YLR192C eIF3j component of translation initiation factor 3 (eIF3) genetic 1 1 1 Negative Genetic
SSD1 YDR293C Translational repressor genetic 1 1 1 Synthetic Lethality
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex genetic 1 1 1 Synthetic Lethality
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-RNA
PUF6 YDR496C Pumilio-homology domain protein physical 1 1 1 Affinity Capture-MS
SUP35 YDR172W Translation termination factor eRF3 genetic 1 1 1 Positive Genetic
ABD1 YBR236C Methyltransferase genetic 1 1 1 Negative Genetic
ATG14 YBR128C Autophagy-specific subunit of phosphatidylinositol 3-kinase complex I physical 1 1 1 Two-hybrid
APL3 YBL037W Alpha-adaptin genetic 1 1 1 Synthetic Lethality
APL5 YPL195W Delta adaptin-like subunit of the clathrin associated protein complex genetic 1 1 1 Synthetic Lethality
APL6 YGR261C Beta3-like subunit of the yeast AP-3 complex genetic 1 1 1 Synthetic Lethality
ARC35 YNR035C Subunit of the ARP2/3 complex genetic 1 1 1 Positive Genetic
ARP2 YDL029W Essential component of the Arp2/3 complex genetic 1 1 1 Synthetic Lethality
ASF1 YJL115W Nucleosome assembly factor physical 1 1 1 Affinity Capture-Western
BDF1 YLR399C BET family transcriptional regulator physical 1 1 1 Affinity Capture-Western
BET3 YKR068C Core component of transport protein particle (TRAPP) complexes I-III genetic 1 1 1 Synthetic Lethality
CCL1 YPR025C Cyclin partner of the cyclin-dependent kinase (CDK) Kin28p genetic 1 1 1 Synthetic Lethality
CDC14 YFR028C Protein phosphatase required for mitotic exit genetic 1 1 1 Synthetic Lethality
CDC24 YAL041W Guanine nucleotide exchange factor (GEF) for Cdc42p genetic 1 1 1 Negative Genetic
CDC12 YHR107C Component of the septin ring that is required for cytokinesis genetic 1 1 1 Synthetic Lethality
CDC3 YLR314C Component of the septin ring that is required for cytokinesis physical 1 1 1 Two-hybrid
CDC36 YDL165W Component of the CCR4-NOT core complex, involved in mRNA decapping genetic 1 1 1 Synthetic Lethality
HDA1 YNL021W Catalytic subunit of class II HDA1 histone deacetylase complex genetic 1 1 1 Synthetic Lethality
HIS3 YOR202W Imidazoleglycerol-phosphate dehydratase genetic 1 1 1 Synthetic Lethality
BUD31 YCR063W Component of the SF3b subcomplex of the U2 snRNP genetic 1 1 1 Synthetic Lethality
AVO1 YOL078W Component of the membrane-bound TORC2 complex genetic 1 1 1 Positive Genetic
CKS1 YBR135W Cyclin-dependent protein kinase regulatory subunit and adaptor genetic 1 1 1 Negative Genetic
CNS1 YBR155W TPR-containing co-chaperone physical 1 1 1 Two-hybrid
COX5A YNL052W Subunit Va of cytochrome c oxidase genetic 1 1 1 Positive Genetic
CPR1 YDR155C Cytoplasmic peptidyl-prolyl cis-trans isomerase (cyclophilin) genetic 1 1 1 Synthetic Lethality
DNA2 YHR164C ATP-dependent 5'-flap endonuclease and DNA helicase genetic 1 1 1 Negative Genetic
CIA2 YHR122W Component of cytosolic iron-sulfur protein assembly (CIA) machinery genetic 1 1 1 Negative Genetic
DOA1 YKL213C WD-repeat protein involved in ubiquitin-mediated protein degradation genetic 1 1 1 Synthetic Lethality
EDE1 YBL047C Scaffold protein involved in the formation of early endocytic sites genetic 1 1 1 Synthetic Lethality
EAF3 YPR023C Component of the Rpd3S histone deacetylase complex genetic 1 1 1 Negative Genetic
FET5 YFL041W Multicopper oxidase genetic 1 1 1 Synthetic Lethality
FKS1 YLR342W Catalytic subunit of 1,3-beta-D-glucan synthase genetic 1 1 1 Synthetic Lethality
CCT4 YDL143W Subunit of the cytosolic chaperonin Cct ring complex genetic 1 1 1 Synthetic Lethality
BDF2 YDL070W Protein involved in transcription initiation genetic 1 1 1 Synthetic Lethality
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
AEP2 YMR282C Mitochondrial protein genetic 1 1 1 Negative Genetic
ATP22 YDR350C Specific translational activator for the mitochondrial ATP6 mRNA genetic 1 1 1 Synthetic Lethality
HHF2 YNL030W Histone H4 physical 1 1 1 Affinity Capture-MS
HST1 YOL068C NAD(+)-dependent histone deacetylase genetic 1 1 1 Negative Genetic
HTB2 YBL002W Histone H2B physical 1 1 1 Affinity Capture-MS
IPP1 YBR011C Cytoplasmic inorganic pyrophosphatase (PPase) genetic 1 1 1 Negative Genetic
COG8 YML071C Component of the conserved oligomeric Golgi complex genetic 1 1 1 Synthetic Lethality
IOC3 YFR013W Subunit of the Isw1a complex physical 1 1 1 Affinity Capture-MS
ESC8 YOL017W Protein involved in telomeric and mating-type locus silencing genetic 1 1 1 Negative Genetic
CLU1 YMR012W Subunit of the eukaryotic translation initiation factor 3 (eIF3) physical 1 1 1 Affinity Capture-MS
LCB1 YMR296C Component of serine palmitoyltransferase genetic 1 1 1 Synthetic Lethality
LCB2 YDR062W Component of serine palmitoyltransferase genetic 1 1 1 Synthetic Lethality
LSM2 YBL026W Lsm (Like Sm) protein genetic 1 1 1 Negative Genetic
LST8 YNL006W Protein required for the transport of Gap1p genetic 1 1 1 Synthetic Lethality
MAK10 YEL053C Non-catalytic subunit of the NatC N-terminal acetyltransferase genetic 1 1 1 Synthetic Lethality
MCM6 YGL201C Protein involved in DNA replication genetic 1 1 1 Negative Genetic
MOT1 YPL082C Essential protein involved in regulation of transcription genetic 1 1 1 Negative Genetic
IMG1 YCR046C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Synthetic Lethality
MRM1 YOR201C Ribose methyltransferase genetic 1 1 1 Synthetic Lethality
MRP49 YKL167C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Synthetic Lethality
MRP10 YDL045W-A Mitochondrial ribosomal protein of the small subunit genetic 1 1 1 Synthetic Lethality
MRP17 YKL003C Mitochondrial ribosomal protein of the small subunit genetic 1 1 1 Synthetic Lethality
CCM1 YGR150C Mitochondrial 15S rRNA-binding protein physical 1 1 1 Two-hybrid
HDA2 YDR295C Subunit of HDA1 histone deacetylase complex genetic 1 1 1 Synthetic Lethality
MSH2 YOL090W Protein that binds to DNA mismatches genetic 1 1 1 Negative Genetic
CMD1 YBR109C Calmodulin genetic 1 1 1 Positive Genetic
HTZ1 YOL012C Histone variant H2AZ genetic 1 1 1 Synthetic Lethality
INO80 YGL150C Nucleosome spacing factor physical 1 1 1 Affinity Capture-MS
NHP10 YDL002C Non-essential INO80 chromatin remodeling complex subunit genetic 1 1 1 Synthetic Lethality
IES1 YFL013C Subunit of the INO80 chromatin remodeling complex genetic 1 1 1 Synthetic Lethality
NHP6B YBR089C-A High-mobility group (HMG) protein physical 1 1 1 PCA
NHP6B YBR089C-A High-mobility group (HMG) protein genetic 1 1 1 Synthetic Lethality
NOT3 YIL038C Component of the CCR4-NOT core complex, involved in mRNA decapping physical 1 1 1 Two-hybrid
NPL4 YBR170C Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase genetic 1 1 1 Negative Genetic
NUP159 YIL115C FG-nucleoporin component of central core of the nuclear pore complex genetic 1 1 1 Synthetic Lethality
GIM3 YNL153C Subunit of the heterohexameric cochaperone prefoldin complex genetic 1 1 1 Negative Genetic
PBP2 YBR233W RNA binding protein genetic 1 1 1 Synthetic Lethality
LPD1 YFL018C Dihydrolipoamide dehydrogenase genetic 1 1 1 Synthetic Lethality
PDA1 YER178W E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex genetic 1 1 1 Negative Genetic
POL12 YBL035C B subunit of DNA polymerase alpha-primase complex genetic 1 1 1 Negative Genetic
PPH22 YDL188C Catalytic subunit of protein phosphatase 2A, PP2A genetic 1 1 1 Synthetic Lethality
HTA1 YDR225W Histone H2A genetic 1 1 1 Synthetic Lethality
PRP31 YGR091W Splicing factor genetic 1 1 1 Negative Genetic
CWC22 YGR278W Spliceosome-associated protein that is required for pre-mRNA splicing genetic 1 1 1 Synthetic Lethality
INO4 YOL108C Transcription factor involved in phospholipid synthesis genetic 1 1 1 Positive Genetic
PSE1 YMR308C Karyopherin/importin that interacts with the nuclear pore complex genetic 1 1 1 Synthetic Lethality
NAB3 YPL190C RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p) genetic 1 1 1 Negative Genetic
POL2 YNL262W Catalytic subunit of DNA polymerase (II) epsilon genetic 1 1 1 Negative Genetic
BUD21 YOR078W Component of small ribosomal subunit (SSU) processosome genetic 1 1 1 Negative Genetic
IMP4 YNL075W Component of the SSU processome genetic 1 1 1 Synthetic Lethality
GCN20 YFR009W Positive regulator of the Gcn2p kinase activity genetic 1 1 1 Synthetic Lethality
MET18 YIL128W Component of cytosolic iron-sulfur protein assembly (CIA) machinery genetic 1 1 1 Negative Genetic
PTI1 YGR156W Essential component of CPF (cleavage and polyadenylation factor) genetic 1 1 1 Synthetic Lethality
RAD52 YML032C Protein involved in homologous recombination genetic 1 1 1 Synthetic Lethality
RFX1 YLR176C Major transcriptional repressor of DNA-damage-regulated genes physical 1 1 1 Reconstituted Complex
RFX1 YLR176C Major transcriptional repressor of DNA-damage-regulated genes genetic 1 1 1 Synthetic Lethality
NUT2 YPR168W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
RPB11 YOL005C RNA polymerase II subunit B12.5 genetic 1 1 1 Synthetic Lethality
DEP1 YAL013W Component of the Rpd3L histone deacetylase complex genetic 1 1 1 Synthetic Lethality
RCO1 YMR075W Essential component of the Rpd3S histone deacetylase complex genetic 1 1 1 Synthetic Lethality
PUP3 YER094C Beta 3 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
MLH2 YLR035C Protein involved in mismatch repair and meiotic recombination genetic 1 1 1 Synthetic Lethality
CSN9 YDR179C Subunit of the Cop9 signalosome genetic 1 1 1 Synthetic Lethality
NUM1 YDR150W Protein required for nuclear migration genetic 1 1 1 Synthetic Lethality
OPI1 YHL020C Transcriptional regulator of a variety of genes genetic 1 1 1 Synthetic Lethality
NUP120 YKL057C Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) genetic 1 1 1 Synthetic Lethality
RPP2B YDR382W Ribosomal protein P2 beta genetic 1 1 1 Negative Genetic
SEC62 YPL094C Essential subunit of Sec63 complex genetic 1 1 1 Negative Genetic
SEC66 YBR171W Non-essential subunit of Sec63 complex genetic 1 1 1 Synthetic Lethality
SAP30 YMR263W Component of Rpd3L histone deacetylase complex genetic 1 1 1 Negative Genetic
BGL2 YGR282C Endo-beta-1,3-glucanase genetic 1 1 1 Synthetic Lethality
PRP9 YDL030W Subunit of the SF3a splicing factor complex genetic 1 1 1 Negative Genetic
SMD1 YGR074W Core Sm protein Sm D1 genetic 1 1 1 Synthetic Lethality
SNF2 YOR290C Catalytic subunit of the SWI/SNF chromatin remodeling complex genetic 1 1 1 Synthetic Lethality
SNF5 YBR289W Subunit of the SWI/SNF chromatin remodeling complex genetic 1 1 1 Synthetic Lethality
PRP38 YGR075C Unique component of the U4/U6.U5 tri-snRNP particle genetic 1 1 1 Synthetic Lethality
PFK2 YMR205C Beta subunit of heterooctameric phosphofructokinase genetic 1 1 1 Negative Genetic
RPT5 YOR117W ATPase of the 19S regulatory particle of the 26S proteasome genetic 1 1 1 Synthetic Lethality
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes physical 1 1 1 Affinity Capture-MS
SPT20 YOL148C Subunit of the SAGA transcriptional regulatory complex physical 1 1 1 Reconstituted Complex
SPT7 YBR081C Subunit of the SAGA transcriptional regulatory complex genetic 1 1 1 Synthetic Lethality
SGF29 YCL010C Component of the HAT/Core module of the SAGA, SLIK, and ADA complexes physical 1 1 1 Two-hybrid
SGF29 YCL010C Component of the HAT/Core module of the SAGA, SLIK, and ADA complexes genetic 1 1 1 Synthetic Lethality
SEC65 YML105C Subunit of the signal recognition particle (SRP) genetic 1 1 1 Synthetic Lethality
SRO9 YCL037C Cytoplasmic RNA-binding protein genetic 1 1 1 Synthetic Lethality
SSE1 YPL106C ATPase component of heat shock protein Hsp90 chaperone complex genetic 1 1 1 Negative Genetic
SSL1 YLR005W Subunit of the core form of RNA polymerase transcription factor TFIIH genetic 1 1 1 Negative Genetic
MSH4 YFL003C Protein involved in meiotic recombination genetic 1 1 1 Synthetic Lethality
SEN1 YLR430W ATP-dependent 5' to 3' RNA/DNA and DNA helicase genetic 1 1 1 Synthetic Lethality
SGV1 YPR161C Cyclin (Bur2p)-dependent protein kinase genetic 1 1 1 Negative Genetic
SNU71 YGR013W Component of U1 snRNP required for mRNA splicing via spliceosome genetic 1 1 1 Synthetic Lethality
MNN4 YKL201C Putative positive regulator of mannosylphosphate transferase Mnn6p physical 1 1 1 Affinity Capture-MS
TAF4 YMR005W TFIID subunit (48 kDa) genetic 1 1 1 Negative Genetic
TAF5 YBR198C Subunit (90 kDa) of TFIID and SAGA complexes genetic 1 1 1 Negative Genetic
TBF1 YPL128C Telobox-containing general regulatory factor physical 1 1 1 Affinity Capture-MS
TAF1 YGR274C TFIID subunit, involved in RNA pol II transcription initiation genetic 1 1 1 Synthetic Lethality
TFA2 YKR062W TFIIE small subunit physical 1 1 1 Co-localization
TFA2 YKR062W TFIIE small subunit genetic 1 1 1 Synthetic Lethality
TFG1 YGR186W TFIIF (Transcription Factor II) largest subunit physical 1 1 1 Co-localization
TFB3 YDR460W Subunit of TFIIH and nucleotide excision repair factor 3 complexes physical 1 1 1 Co-localization
YET3 YDL072C Protein of unknown function physical 1 1 1 Two-hybrid
VFA1 YER128W Protein that interacts with Vps4p and has a role in vacuolar sorting physical 1 1 1 Two-hybrid
YTA7 YGR270W Chromatin-binding ATPase that regulates histone gene expression physical 1 1 1 Two-hybrid
YTA7 YGR270W Chromatin-binding ATPase that regulates histone gene expression genetic 1 1 1 Synthetic Lethality
YJL113W YJL113W Retrotransposon TYA Gag and TYB Pol genes physical 1 1 1 Two-hybrid
YKL050C YKL050C Protein of unknown function physical 1 1 1 Two-hybrid
VMA5 YKL080W Subunit C of the V1 peripheral membrane domain of V-ATPase physical 1 1 1 Two-hybrid
TOA2 YKL058W TFIIA small subunit genetic 1 1 1 Dosage Rescue
YPT6 YLR262C Rab family GTPase genetic 1 1 1 Negative Genetic
YOL036W YOL036W Protein of unknown function genetic 1 1 1 Negative Genetic
WHI5 YOR083W Repressor of G1 transcription genetic 1 1 1 Phenotypic Suppression
TPD3 YAL016W Regulatory subunit A of the heterotrimeric PP2A complex genetic 1 1 1 Synthetic Lethality
YBL028C YBL028C Protein of unknown function that may interact with ribosomes genetic 1 1 1 Synthetic Lethality
TOD6 YBL054W PAC motif binding protein involved in rRNA and ribosome biogenesis genetic 1 1 1 Synthetic Lethality
TCM62 YBR044C Protein involved in assembly of the succinate dehydrogenase complex genetic 1 1 1 Synthetic Lethality
UBC4 YBR082C Ubiquitin-conjugating enzyme (E2) genetic 1 1 1 Synthetic Lethality
VPS15 YBR097W Serine/threonine protein kinase involved in vacuolar protein sorting genetic 1 1 1 Synthetic Lethality
YBR137W YBR137W Protein with a role in ER delivery of tail-anchored membrane proteins genetic 1 1 1 Synthetic Lethality
YSY6 YBR162W-A Protein of unknown function genetic 1 1 1 Synthetic Lethality
YBR284W YBR284W Putative metallo-dependent hydrolase superfamily protein genetic 1 1 1 Synthetic Lethality
YCL002C YCL002C Putative protein of unknown function genetic 1 1 1 Synthetic Lethality
YDL124W YDL124W NADPH-dependent alpha-keto amide reductase genetic 1 1 1 Synthetic Lethality
VPS54 YDR027C Component of the GARP (Golgi-associated retrograde protein) complex genetic 1 1 1 Synthetic Lethality
VPS41 YDR080W Subunit of the HOPS endocytic tethering complex genetic 1 1 1 Synthetic Lethality
UBC1 YDR177W Ubiquitin-conjugating enzyme genetic 1 1 1 Synthetic Lethality
VPS64 YDR200C Protein required for cytoplasm to vacuole targeting of proteins genetic 1 1 1 Synthetic Lethality
YDR239C YDR239C Protein of unknown function genetic 1 1 1 Synthetic Lethality
YDR246W-A YDR246W-A Putative protein of unknown function genetic 1 1 1 Synthetic Lethality
YFT2 YDR319C Protein needed for ER membrane biosynthesis in response to ER stress genetic 1 1 1 Synthetic Lethality
YCG1 YDR325W Subunit of the condensin complex genetic 1 1 1 Synthetic Lethality
VPS60 YDR486C Protein involved in late endosome to vacuole transport genetic 1 1 1 Synthetic Lethality
VMA3 YEL027W Proteolipid subunit c of the V0 domain of vacuolar H(+)-ATPase genetic 1 1 1 Synthetic Lethality
UTR4 YEL038W Protein with sequence similarity to acireductone synthases genetic 1 1 1 Synthetic Lethality
VMA8 YEL051W Subunit D of the V1 peripheral membrane domain of V-ATPase genetic 1 1 1 Synthetic Lethality
TMA20 YER007C-A Protein of unknown function that associates with ribosomes genetic 1 1 1 Synthetic Lethality
TOG1 YER184C Transcriptional activator of oleate genes genetic 1 1 1 Synthetic Lethality
YPT1 YFL038C Rab family GTPase genetic 1 1 1 Synthetic Lethality
ZNF1 YFL052W Zinc cluster transcription factor that regulates respiratory growth genetic 1 1 1 Synthetic Lethality
YGL007C-A YGL007C-A Putative protein of unknown function genetic 1 1 1 Synthetic Lethality
YGL114W YGL114W Putative protein of unknown function genetic 1 1 1 Synthetic Lethality
VAM7 YGL212W Vacuolar SNARE protein genetic 1 1 1 Synthetic Lethality
TAN1 YGL232W Putative tRNA acetyltransferase genetic 1 1 1 Synthetic Lethality
YGL262W YGL262W Putative protein of unknown function genetic 1 1 1 Synthetic Lethality
VMA7 YGR020C Subunit F of the V1 peripheral membrane domain of V-ATPase genetic 1 1 1 Synthetic Lethality
TIM21 YGR033C Nonessential component of the TIM23 complex genetic 1 1 1 Synthetic Lethality
YGR035C YGR035C Putative protein of unknown function, potential Cdc28p substrate genetic 1 1 1 Synthetic Lethality
YGR054W YGR054W Eukaryotic initiation factor eIF2A genetic 1 1 1 Synthetic Lethality
UTP22 YGR090W Component of the small-subunit processome genetic 1 1 1 Synthetic Lethality
VOA1 YGR106C ER protein that functions in assembly of the V0 sector of V-ATPase genetic 1 1 1 Synthetic Lethality
YGR130C YGR130C Component of the eisosome with unknown function genetic 1 1 1 Synthetic Lethality
XKS1 YGR194C Xylulokinase genetic 1 1 1 Synthetic Lethality
YHB1 YGR234W Nitric oxide oxidoreductase genetic 1 1 1 Synthetic Lethality
YAP1802 YGR241C Protein of the AP180 family, involved in clathrin cage assembly genetic 1 1 1 Synthetic Lethality
YGR266W YGR266W Protein of unknown function genetic 1 1 1 Synthetic Lethality
YOR1 YGR281W Plasma membrane ATP-binding cassette (ABC) transporter genetic 1 1 1 Synthetic Lethality
ZUO1 YGR285C Ribosome-associated chaperone genetic 1 1 1 Synthetic Lethality
VMA16 YHR026W Subunit c'' of the vacuolar ATPase genetic 1 1 1 Synthetic Lethality
TRR2 YHR106W Mitochondrial thioredoxin reductase genetic 1 1 1 Synthetic Lethality
UBA4 YHR111W E1-like protein that activates Urm1p before urmylation genetic 1 1 1 Synthetic Lethality
YHR175W-A YHR175W-A Putative protein of unknown function genetic 1 1 1 Synthetic Lethality
VID28 YIL017C GID Complex subunit, serves as adaptor for regulatory subunit Vid24p genetic 1 1 1 Synthetic Lethality
YKE4 YIL023C Zinc transporter genetic 1 1 1 Synthetic Lethality
TED1 YIL039W GPI-glycan remodelase genetic 1 1 1 Synthetic Lethality
YIL152W YIL152W Putative protein of unknown function genetic 1 1 1 Synthetic Lethality
YAP5 YIR018W Basic leucine zipper (bZIP) iron-sensing transcription factor genetic 1 1 1 Synthetic Lethality
YJL118W YJL118W Protein of unknown function genetic 1 1 1 Synthetic Lethality
YAK1 YJL141C Serine-threonine protein kinase genetic 1 1 1 Synthetic Lethality
TMA19 YKL056C Protein that associates with ribosomes genetic 1 1 1 Synthetic Lethality
TGL1 YKL140W Steryl ester hydrolase genetic 1 1 1 Synthetic Lethality
TPK3 YKL166C cAMP-dependent protein kinase catalytic subunit genetic 1 1 1 Synthetic Lethality
TOR2 YKL203C PIK-related protein kinase and rapamycin target genetic 1 1 1 Synthetic Lethality
UIP5 YKR044W Protein of unknown function that interacts with Ulp1p genetic 1 1 1 Synthetic Lethality
YSR3 YKR053C Dihydrosphingosine 1-phosphate phosphatase genetic 1 1 1 Synthetic Lethality
YLL053C YLL053C Putative protein genetic 1 1 1 Synthetic Lethality
YLR001C YLR001C Putative protein of unknown function genetic 1 1 1 Synthetic Lethality
THI73 YLR004C Putative plasma membrane permease genetic 1 1 1 Synthetic Lethality
TML25 YLR118C Acyl-protein thioesterase responsible for depalmitoylation of Gpa1p genetic 1 1 1 Synthetic Lethality
YPS3 YLR121C Aspartic protease genetic 1 1 1 Synthetic Lethality
USB1 YLR132C Putative poly(U)-specific 3'-to-5' RNA exonuclease genetic 1 1 1 Synthetic Lethality
YCS4 YLR272C Subunit of the condensin complex genetic 1 1 1 Synthetic Lethality
YLR278C YLR278C Zinc-cluster protein genetic 1 1 1 Synthetic Lethality
YLR297W YLR297W Protein of unknown function genetic 1 1 1 Synthetic Lethality
VID22 YLR373C G-quadruplex (G4) DNA binding protein genetic 1 1 1 Synthetic Lethality
TUS1 YLR425W Guanine nucleotide exchange factor (GEF) that modulates Rho1p activity genetic 1 1 1 Synthetic Lethality
YLR460C YLR460C Member of the quinone oxidoreductase family genetic 1 1 1 Synthetic Lethality
USA1 YML029W Scaffold subunit of the Hrd1p ubiquitin ligase genetic 1 1 1 Synthetic Lethality
YML079W YML079W Non-essential protein of unknown function genetic 1 1 1 Synthetic Lethality
TDA9 YML081W Transcription factor that regulates acetate production genetic 1 1 1 Synthetic Lethality
YML082W YML082W Putative protein predicted to have carbon-sulfur lyase activity genetic 1 1 1 Synthetic Lethality
YML083C YML083C Protein of unknown function genetic 1 1 1 Synthetic Lethality
YMR001C-A YMR001C-A Putative protein of unknown function genetic 1 1 1 Synthetic Lethality
TVP18 YMR071C Integral membrane protein genetic 1 1 1 Synthetic Lethality
YMR160W YMR160W Protein of unknown function genetic 1 1 1 Synthetic Lethality
YMR242W-A YMR242W-A Putative protein of unknown function genetic 1 1 1 Synthetic Lethality
YMR244W YMR244W Putative protein of unknown function genetic 1 1 1 Synthetic Lethality
YNL034W YNL034W Putative protein of unknown function genetic 1 1 1 Synthetic Lethality
YNL040W YNL040W Protein of unknown function genetic 1 1 1 Synthetic Lethality
YNL108C YNL108C Protein phosphatase genetic 1 1 1 Synthetic Lethality
TOM22 YNL131W Component of the TOM (Translocase of Outer Membrane) complex genetic 1 1 1 Synthetic Lethality
YNL165W YNL165W Putative protein of unknown function genetic 1 1 1 Synthetic Lethality
YNL194C YNL194C Integral membrane protein genetic 1 1 1 Synthetic Lethality
ZWF1 YNL241C Glucose-6-phosphate dehydrogenase (G6PD) genetic 1 1 1 Synthetic Lethality
TRF5 YNL299W Non-canonical poly(A) polymerase genetic 1 1 1 Synthetic Lethality
VNX1 YNL321W Calcium/H+ antiporter localized to the endoplasmic reticulum membrane genetic 1 1 1 Synthetic Lethality
THI12 YNL332W Protein involved in synthesis of the thiamine precursor HMP genetic 1 1 1 Synthetic Lethality
YNR066C YNR066C Putative membrane-localized protein of unknown function genetic 1 1 1 Synthetic Lethality
THP1 YOL072W Nuclear pore-associated protein genetic 1 1 1 Synthetic Lethality
YGK3 YOL128C Protein kinase related to mammalian GSK-3 glycogen synthase kinases genetic 1 1 1 Synthetic Lethality
VPS17 YOR132W Subunit of the membrane-associated retromer complex genetic 1 1 1 Synthetic Lethality
YTM1 YOR272W Ribosomal assembly factor and 66S pre-ribosomal particle constituent genetic 1 1 1 Synthetic Lethality
YOR283W YOR283W Phosphatase with a broad substrate specificity genetic 1 1 1 Synthetic Lethality
YPK9 YOR291W Vacuolar protein with a possible role in sequestering heavy metals genetic 1 1 1 Synthetic Lethality
TEA1 YOR337W Ty1 enhancer activator involved in Ty enhancer-mediated transcription genetic 1 1 1 Synthetic Lethality
YPL039W YPL039W Putative protein of unknown function genetic 1 1 1 Synthetic Lethality
VMA11 YPL234C Vacuolar ATPase V0 domain subunit c' genetic 1 1 1 Synthetic Lethality
THP3 YPR045C Protein that may have a role in transcription elongation genetic 1 1 1 Synthetic Lethality
YPR108W-A YPR108W-A Putative protein of unknown function genetic 1 1 1 Synthetic Lethality
TDA6 YPR157W Putative protein of unknown function genetic 1 1 1 Synthetic Lethality
TCP1 YDR212W Alpha subunit of chaperonin-containing T-complex genetic 1 1 1 Positive Genetic
YKT6 YKL196C Vesicle membrane protein (v-SNARE) with acyltransferase activity genetic 1 1 1 Positive Genetic
UME6 YDR207C Rpd3L histone deacetylase complex subunit genetic 1 1 1 Positive Genetic
YJL218W YJL218W Mitochondrial protein, putative acetyltransferase genetic 1 1 1 Positive Genetic
YJR084W YJR084W Protein that forms a complex with Thp3p genetic 1 1 1 Positive Genetic
UFD1 YGR048W Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase genetic 1 1 1 Negative Genetic
TFB1 YDR311W Subunit of TFIIH and nucleotide excision repair factor 3 complexes genetic 1 1 1 Negative Genetic
TAH11 YJR046W DNA replication licensing factor genetic 1 1 1 Negative Genetic
THI80 YOR143C Thiamine pyrophosphokinase genetic 1 1 1 Negative Genetic
TFB4 YPR056W Subunit of TFIIH complex genetic 1 1 1 Negative Genetic
YTH1 YPR107C Essential RNA-binding component of cleavage and polyadenylation factor genetic 1 1 1 Negative Genetic
YJR011C YJR011C Putative protein of unknown function genetic 1 1 1 Negative Genetic
YKL069W YKL069W Methionine-R-sulfoxide reductase genetic 1 1 1 Negative Genetic
YLR407W YLR407W Putative protein of unknown function genetic 1 1 1 Negative Genetic
TMA23 YMR269W Nucleolar protein implicated in ribosome biogenesis genetic 1 1 1 Negative Genetic
YOR062C YOR062C Protein of unknown function genetic 1 1 1 Negative Genetic
UBA3 YPR066W Protein that activates Rub1p (NEDD8) before neddylation genetic 1 1 1 Negative Genetic
THR4 YCR053W Threonine synthase genetic 1 1 1 Negative Genetic
UGX2 YDL169C Protein of unknown function genetic 1 1 1 Negative Genetic
YIL054W YIL054W Protein of unknown function genetic 1 1 1 Negative Genetic
VTC4 YJL012C Vacuolar membrane polyphosphate polymerase genetic 1 1 1 Negative Genetic
YML108W YML108W Protein of unknown function genetic 1 1 1 Negative Genetic
YDJ1 YNL064C Type I HSP40 co-chaperone genetic 1 1 1 Negative Genetic
VPS27 YNR006W Endosomal protein that forms a complex with Hse1p genetic 1 1 1 Negative Genetic
YAR1 YPL239W Nucleocytoplasmic shuttling assembly chaperone genetic 1 1 1 Negative Genetic
YBR062C YBR062C Protein of unknown function that interacts with Msb2p genetic 1 1 1 Negative Genetic
YDL144C YDL144C Protein of unknown function genetic 1 1 1 Negative Genetic
VEL1 YGL258W Protein of unknown function genetic 1 1 1 Negative Genetic
YHR086W-A YHR086W-A Putative protein of unknown function genetic 1 1 1 Negative Genetic
YJL077W-B YJL077W-B Putative protein of unknown function genetic 1 1 1 Negative Genetic
VBA5 YKR105C Plasma membrane protein of the Major Facilitator Superfamily (MFS) genetic 1 1 1 Negative Genetic
TAL1 YLR354C Transaldolase, enzyme in the non-oxidative pentose phosphate pathway genetic 1 1 1 Negative Genetic
VBA1 YMR088C Permease of basic amino acids in the vacuolar membrane genetic 1 1 1 Negative Genetic
YNL097C-B YNL097C-B Putative protein of unknown function genetic 1 1 1 Negative Genetic
YNL195C YNL195C Protein of unknown function genetic 1 1 1 Negative Genetic
TMC1 YOR052C AN1-type zinc finger protein, effector of proteotoxic stress response genetic 1 1 1 Negative Genetic
TCB1 YOR086C Lipid-binding ER protein involved in ER-plasma membrane tethering genetic 1 1 1 Negative Genetic
YOR097C YOR097C Putative protein of unknown function genetic 1 1 1 Negative Genetic
YPR027C YPR027C Putative protein of unknown function genetic 1 1 1 Negative Genetic
SPT8 YLR055C Subunit of the SAGA transcriptional regulatory complex physical 1 1 1 Reconstituted Complex
CCT6 YDR188W Subunit of the cytosolic chaperonin Cct ring complex genetic 1 1 1 Positive Genetic
CAM1 YPL048W One of two isoforms of the gamma subunit of eEF1B genetic 1 1 1 Synthetic Lethality
NEW1 YPL226W Translation termination and ribosome biogenesis factor genetic 1 1 1 Negative Genetic
KTR5 YNL029C Putative mannosyltransferase involved in protein glycosylation genetic 1 1 1 Negative Genetic
SPT5 YML010W Spt4p/5p (DSIF) transcription elongation factor complex subunit genetic 1 1 1 Synthetic Lethality
GLN1 YPR035W Glutamine synthetase (GS) genetic 1 1 1 Synthetic Lethality
RPT4 YOR259C ATPase of the 19S regulatory particle of the 26S proteasome genetic 1 1 1 Negative Genetic
HSE1 YHL002W Subunit of the endosomal Vps27p-Hse1p complex genetic 1 1 1 Synthetic Lethality
BRO1 YPL084W Cytoplasmic class E vacuolar protein sorting (VPS) factor genetic 1 1 1 Synthetic Lethality
SNF7 YLR025W One of four subunits of the ESCRT-III complex genetic 1 1 1 Synthetic Lethality
SWP1 YMR149W Delta subunit of the oligosaccharyl transferase glycoprotein complex genetic 1 1 1 Synthetic Lethality
SAW1 YAL027W 5'- and 3'-flap DNA binding protein genetic 1 1 1 Synthetic Lethality
FUN19 YAL034C Non-essential protein of unknown function physical 1 1 1 Affinity Capture-MS
SSZ1 YHR064C Hsp70 protein that interacts with Zuo1p (a DnaJ homolog) genetic 1 1 1 Synthetic Lethality
BOI1 YBL085W Protein involved in polar growth, functionally redundant with Boi2p genetic 1 1 1 Synthetic Lethality
GET3 YDL100C Guanine nucleotide exchange factor for Gpa1p genetic 1 1 1 Synthetic Lethality
CYM1 YDR430C Lysine-specific metalloprotease of the pitrilysin family genetic 1 1 1 Synthetic Lethality
LPL1 YOR059C Phospholipase genetic 1 1 1 Synthetic Lethality
LSM12 YHR121W Protein of unknown function that may function in RNA processing physical 1 1 1 Affinity Capture-MS
NTE1 YML059C Serine esterase genetic 1 1 1 Synthetic Lethality
ATP2 YJR121W Beta subunit of the F1 sector of mitochondrial F1F0 ATP synthase genetic 1 1 1 Negative Genetic
SSU72 YNL222W Phosphatase and transcription/RNA-processing factor genetic 1 1 1 Synthetic Lethality
SKI3 YPR189W Ski complex component and TPR protein genetic 1 1 1 Synthetic Lethality
ATP4 YPL078C Subunit b of the stator stalk of mitochondrial F1F0 ATP synthase physical 1 1 1 Two-hybrid
ABP1 YCR088W Actin-binding protein of the cortical actin cytoskeleton genetic 1 1 1 Negative Genetic
GAS1 YMR307W Beta-1,3-glucanosyltransferase required for cell wall assembly genetic 1 1 1 Synthetic Lethality
ACO1 YLR304C Aconitase genetic 1 1 1 Synthetic Lethality
BBC1 YJL020C Protein possibly involved in assembly of actin patches genetic 1 1 1 Synthetic Lethality
MDH1 YKL085W Mitochondrial malate dehydrogenase genetic 1 1 1 Synthetic Lethality
PHO85 YPL031C Cyclin-dependent kinase genetic 1 1 1 Synthetic Lethality
CAF20 YOR276W Phosphoprotein of the mRNA cap-binding complex physical 1 1 1 Affinity Capture-RNA
GRH1 YDR517W Acetylated cis-Golgi protein, homolog of human GRASP65 genetic 1 1 1 Synthetic Lethality
ATG17 YLR423C Scaffold protein responsible for phagophore assembly site organization genetic 1 1 1 Synthetic Lethality
FOL2 YGR267C GTP-cyclohydrolase I, catalyzes first step in folic acid biosynthesis genetic 1 1 1 Synthetic Lethality
STI1 YOR027W Evolutionarily-conserved Hsp90 cochaperone genetic 1 1 1 Synthetic Lethality
DMA2 YNL116W Ubiquitin-protein ligase (E3) genetic 1 1 1 Synthetic Lethality
MGE1 YOR232W Mitochondrial matrix cochaperone genetic 1 1 1 Synthetic Lethality
HTB1 YDR224C Histone H2B physical 1 1 1 Affinity Capture-MS
HIR3 YJR140C Subunit of the HIR complex physical 1 1 1 Affinity Capture-MS
HIR3 YJR140C Subunit of the HIR complex genetic 1 1 1 Synthetic Lethality
RVS161 YCR009C Amphiphysin-like lipid raft protein genetic 1 1 1 Negative Genetic
PMA2 YPL036W Plasma membrane H+-ATPase genetic 1 1 1 Negative Genetic
PIB1 YDR313C RING-type ubiquitin ligase of the endosomal and vacuolar membranes genetic 1 1 1 Synthetic Lethality
AAT2 YLR027C Cytosolic aspartate aminotransferase involved in nitrogen metabolism genetic 1 1 1 Synthetic Lethality
GET2 YER083C Subunit of the GET complex genetic 1 1 1 Synthetic Lethality
DUN1 YDL101C Cell-cycle checkpoint S/T protein kinase genetic 1 1 1 Negative Genetic
SLX5 YDL013W Subunit of the Slx5-Slx8 SUMO-targeted Ub ligase (STUbL) complex genetic 1 1 1 Negative Genetic
CLN1 YMR199W G1 cyclin involved in regulation of the cell cycle genetic 1 1 1 Synthetic Lethality
PKH2 YOL100W Serine/threonine protein kinase genetic 1 1 1 Synthetic Lethality
SEC18 YBR080C AAA ATPase and SNARE disassembly chaperone genetic 1 1 1 Negative Genetic
APT1 YML022W Adenine phosphoribosyltransferase genetic 1 1 1 Synthetic Lethality
MET30 YIL046W F-box protein containing five copies of the WD40 motif genetic 1 1 1 Synthetic Lethality
DOP1 YDR141C Protein involved in vesicular transport at trans-Golgi network (TGN) genetic 1 1 1 Synthetic Lethality
PSH1 YOL054W E3 ubiquitin ligase targeting centromere-binding protein Cse4p genetic 1 1 1 Synthetic Lethality
GAC1 YOR178C Regulatory subunit for Glc7p type-1 protein phosphatase (PP1) genetic 1 1 1 Synthetic Lethality
PDS1 YDR113C Securin genetic 1 1 1 Synthetic Lethality
DAS1 YJL149W Putative SCF ubiquitin ligase F-box protein genetic 1 1 1 Synthetic Lethality
ADH3 YMR083W Mitochondrial alcohol dehydrogenase isozyme III genetic 1 1 1 Synthetic Lethality
PSK2 YOL045W PAS-domain containing serine/threonine protein kinase genetic 1 1 1 Synthetic Lethality
FHL1 YPR104C Regulator of ribosomal protein (RP) transcription genetic 1 1 1 Synthetic Lethality
LSB1 YGR136W Negative regulator of actin nucleation-promoting factor activity genetic 1 1 1 Synthetic Lethality
ADH4 YGL256W Alcohol dehydrogenase isoenzyme type IV genetic 1 1 1 Synthetic Lethality
OCA1 YNL099C Putative protein tyrosine phosphatase genetic 1 1 1 Synthetic Lethality
CDC37 YDR168W Essential Hsp90p co-chaperone physical 1 1 1 Two-hybrid
RVS167 YDR388W Calmodulin-binding actin-associated protein genetic 1 1 1 Negative Genetic
CDC4 YFL009W F-box protein required for both the G1/S and G2/M phase transitions genetic 1 1 1 Synthetic Lethality
GND2 YGR256W 6-phosphogluconate dehydrogenase (decarboxylating) genetic 1 1 1 Synthetic Lethality
ERG6 YML008C Delta(24)-sterol C-methyltransferase genetic 1 1 1 Negative Genetic
PRM2 YIL037C Pheromone-regulated protein genetic 1 1 1 Synthetic Lethality
ISN1 YOR155C Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase genetic 1 1 1 Synthetic Lethality
HIR1 YBL008W Subunit of the HIR complex genetic 1 1 1 Synthetic Lethality
MNP1 YGL068W Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Synthetic Lethality
CIN8 YEL061C Bipolar kinesin motor protein genetic 1 1 1 Synthetic Lethality
SXM1 YDR395W Nuclear transport factor (karyopherin) genetic 1 1 1 Synthetic Lethality
CBP3 YPL215W Mitochondrial protein required for assembly of cytochrome bc1 complex genetic 1 1 1 Synthetic Lethality
LAS1 YKR063C Endonuclease involved in pre-rRNA processing at both ends of ITS2 genetic 1 1 1 Synthetic Lethality
CHS1 YNL192W Chitin synthase I genetic 1 1 1 Synthetic Lethality
HIR2 YOR038C Subunit of HIR nucleosome assembly complex genetic 1 1 1 Synthetic Lethality
CBP6 YBR120C Mitochondrial protein required for translation of the COB mRNA genetic 1 1 1 Negative Genetic
ACS1 YAL054C Acetyl-coA synthetase isoform genetic 1 1 1 Synthetic Lethality
SHE3 YBR130C Protein adaptor between Myo4p and the She2p-mRNA complex physical 1 1 1 Affinity Capture-MS
HHT1 YBR010W Histone H3 physical 1 1 1 Affinity Capture-MS
SGT1 YOR057W Cochaperone protein genetic 1 1 1 Negative Genetic
MRE11 YMR224C Nuclease subunit of the MRX complex with Rad50p and Xrs2p genetic 1 1 1 Synthetic Lethality
MKK2 YPL140C MAPKK involved in the protein kinase C signaling pathway genetic 1 1 1 Synthetic Lethality
HOM3 YER052C Aspartate kinase (L-aspartate 4-P-transferase) genetic 1 1 1 Synthetic Lethality
RGI1 YER067W Protein involved in energy metabolism under respiratory conditions genetic 1 1 1 Negative Genetic
FPK1 YNR047W Ser/Thr protein kinase genetic 1 1 1 Synthetic Lethality
NOP13 YNL175C Nucleolar protein found in preribosomal complexes genetic 1 1 1 Synthetic Lethality
SEC4 YFL005W Rab family GTPase genetic 1 1 1 Synthetic Lethality
MIH1 YMR036C Protein tyrosine phosphatase genetic 1 1 1 Synthetic Lethality
NOP53 YPL146C Nucleolar protein physical 1 1 1 Two-hybrid
LAA1 YJL207C AP-1 accessory protein physical 1 1 1 Two-hybrid
SSN8 YNL025C Cyclin-like component of RNA polymerase II holoenzyme genetic 1 1 1 Synthetic Lethality
APA1 YCL050C AP4A phosphorylase genetic 1 1 1 Synthetic Lethality
RAD53 YPL153C DNA damage response kinase genetic 1 1 1 Negative Genetic
MAS2 YHR024C Alpha subunit of the mitochondrial processing protease (MPP) genetic 1 1 1 Negative Genetic
CTR1 YPR124W High-affinity copper transporter of plasma membrane genetic 1 1 1 Synthetic Lethality
EAP1 YKL204W eIF4E-associated protein, competes with eIF4G for binding to eIF4E genetic 1 1 1 Synthetic Lethality
SSL2 YIL143C Component of RNA polymerase transcription factor TFIIH holoenzyme genetic 1 1 1 Synthetic Lethality
PTC6 YCR079W Mitochondrial type 2C protein phosphatase (PP2C) genetic 1 1 1 Synthetic Lethality
SOF1 YLL011W Protein required for biogenesis of 40S (small) ribosomal subunit genetic 1 1 1 Synthetic Lethality
PPZ1 YML016C Serine/threonine protein phosphatase Z, isoform of Ppz2p genetic 1 1 1 Synthetic Lethality
SEF1 YBL066C Putative transcription factor genetic 1 1 1 Synthetic Lethality
PFU1 YDR306C F-box protein that regulates pheromone-dependent morphogenesis genetic 1 1 1 Synthetic Lethality
CBR1 YIL043C Cytochrome b reductase and NADH-dependent reductase for Dph3p genetic 1 1 1 Synthetic Lethality
CLN2 YPL256C G1 cyclin involved in regulation of the cell cycle genetic 1 1 1 Negative Genetic
CSC1 YLR241W Calcium permeable gated cation channel genetic 1 1 1 Synthetic Lethality
RAD26 YJR035W Protein involved in transcription-coupled nucleotide excision repair physical 1 1 1 Two-hybrid
PRS2 YER099C 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase genetic 1 1 1 Synthetic Lethality
APE2 YKL157W Aminopeptidase yscII genetic 1 1 1 Synthetic Lethality
CMG1 YLR271W Putative protein of unknown function genetic 1 1 1 Synthetic Lethality
EXO70 YJL085W Subunit of the exocyst complex genetic 1 1 1 Negative Genetic
IGO1 YNL157W Protein required for initiation of G0 program genetic 1 1 1 Synthetic Lethality
JJJ1 YNL227C Co-chaperone that stimulates the ATPase activity of Ssa1p genetic 1 1 1 Synthetic Lethality
ERG11 YHR007C Lanosterol 14-alpha-demethylase genetic 1 1 1 Negative Genetic
EFM1 YHL039W Lysine methyltransferase genetic 1 1 1 Synthetic Lethality
SRV2 YNL138W CAP (cyclase-associated protein) genetic 1 1 1 Negative Genetic
ATP7 YKL016C Subunit d of the stator stalk of mitochondrial F1F0 ATP synthase physical 1 1 1 Two-hybrid
CTK3 YML112W Gamma subunit of C-terminal domain kinase I genetic 1 1 1 Synthetic Lethality
DAD1 YDR016C Essential subunit of the Dam1 complex (aka DASH complex) genetic 1 1 1 Negative Genetic
DAD2 YKR083C Essential subunit of the Dam1 complex (aka DASH complex) genetic 1 1 1 Synthetic Lethality
BIT2 YBR270C Subunit of TORC2 membrane-associated complex genetic 1 1 1 Negative Genetic
MCM10 YIL150C Essential chromatin-associated protein genetic 1 1 1 Negative Genetic
BIM1 YER016W Microtubule plus end-tracking protein genetic 1 1 1 Synthetic Lethality
DCI1 YOR180C Peroxisomal protein genetic 1 1 1 Synthetic Lethality
AFT1 YGL071W Transcription factor involved in iron utilization and homeostasis genetic 1 1 1 Synthetic Lethality
IME4 YGL192W mRNA N6-adenosine methyltransferase genetic 1 1 1 Synthetic Lethality
INO2 YDR123C Transcription factor physical 1 1 1 Reconstituted Complex
BSC5 YNR069C Protein of unknown function genetic 1 1 1 Synthetic Lethality
ATG19 YOL082W Receptor protein for the cytoplasm-to-vacuole targeting (Cvt) pathway genetic 1 1 1 Synthetic Lethality
LST7 YGR057C Subunit of the Lst4p-Lst7p GTPase activating protein complex for Gtr2p genetic 1 1 1 Synthetic Lethality
MCM16 YPR046W Component of the Ctf19 complex and the COMA subcomplex genetic 1 1 1 Negative Genetic
GCN4 YEL009C bZIP transcriptional activator of amino acid biosynthetic genes physical 1 1 1 Affinity Capture-Western
MPD2 YOL088C Member of the protein disulfide isomerase (PDI) family genetic 1 1 1 Synthetic Lethality
ATG39 YLR312C Transmembrane receptor with a role in nucleophagy genetic 1 1 1 Synthetic Lethality
MSH5 YDL154W Protein of the MutS family genetic 1 1 1 Synthetic Lethality
NUF2 YOL069W Component of the kinetochore-associated Ndc80 complex genetic 1 1 1 Synthetic Lethality
PDR8 YLR266C Transcription factor genetic 1 1 1 Synthetic Lethality
DON1 YDR273W Meiosis-specific component of the spindle pole body genetic 1 1 1 Synthetic Lethality
CDC34 YDR054C Ubiquitin-conjugating enzyme (E2) genetic 1 1 1 Synthetic Lethality
BAS1 YKR099W Myb-related transcription factor genetic 1 1 1 Negative Genetic
PRR2 YDL214C Serine/threonine protein kinase genetic 1 1 1 Synthetic Lethality
ACF4 YJR083C Protein of unknown function physical 1 1 1 Two-hybrid
SPO1 YNL012W Meiosis-specific prospore protein genetic 1 1 1 Negative Genetic
ECI1 YLR284C Peroxisomal delta3,delta2-enoyl-CoA isomerase genetic 1 1 1 Synthetic Lethality
BNA6 YFR047C Quinolinate phosphoribosyl transferase genetic 1 1 1 Synthetic Lethality
ADY3 YDL239C Protein required for spore wall formation genetic 1 1 1 Synthetic Lethality
IRC6 YFR043C Clathrin coat accessory factor genetic 1 1 1 Synthetic Lethality
ART5 YGR068C Protein proposed to regulate endocytosis of plasma membrane proteins genetic 1 1 1 Synthetic Lethality
GPN2 YOR262W Putative GTPase with a specific role in RNA pol II and polIII biogenes genetic 1 1 1 Synthetic Lethality
CUE2 YKL090W Ubiquitin-binding endonuclease involved in mRNA decay genetic 1 1 1 Synthetic Lethality
ASK10 YGR097W Regulator of the Fps1p glycerol channel genetic 1 1 1 Negative Genetic
ELP6 YMR312W Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex genetic 1 1 1 Synthetic Lethality
SMC5 YOL034W Subunit of the SMC5-SMC6 complex genetic 1 1 1 Negative Genetic
HUA1 YGR268C Cytoplasmic protein containing a zinc finger domain genetic 1 1 1 Synthetic Lethality
NST1 YNL091W Translational inhibitor and suppressor of proteasome-assembly defects genetic 1 1 1 Negative Genetic
APC5 YOR249C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 1 1 1 Synthetic Lethality
CEP3 YMR168C Essential kinetochore protein genetic 1 1 1 Negative Genetic
COG7 YGL005C Component of the conserved oligomeric Golgi complex genetic 1 1 1 Synthetic Lethality
ELP3 YPL086C Subunit of Elongator complex genetic 1 1 1 Negative Genetic
IPL1 YPL209C Aurora kinase of chromosomal passenger complex genetic 1 1 1 Synthetic Lethality
NNF1 YJR112W Essential component of the outer kinetochore MIND complex genetic 1 1 1 Synthetic Lethality
PEX5 YDR244W Peroxisomal membrane signal receptor for peroxisomal matrix proteins genetic 1 1 1 Synthetic Lethality
CHL1 YPL008W Probable DNA helicase genetic 1 1 1 Synthetic Lethality
RPL9B YNL067W Ribosomal 60S subunit protein L9B genetic 1 1 1 Synthetic Lethality
RPS24A YER074W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Synthetic Lethality
BRE5 YNR051C Ubiquitin protease cofactor genetic 1 1 1 Negative Genetic
CET1 YPL228W RNA 5'-triphosphatase involved in mRNA 5' capping genetic 1 1 1 Synthetic Lethality
NHP6A YPR052C High-mobility group (HMG) protein physical 1 1 1 PCA
SPT3 YDR392W Subunit of the SAGA and SAGA-like transcriptional regulatory complexes physical 1 1 1 Reconstituted Complex
SWC5 YBR231C Component of the SWR1 complex genetic 1 1 1 Negative Genetic
SRB7 YDR308C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
IES4 YOR189W Component of the INO80 chromatiin remodeling complex genetic 1 1 1 Synthetic Lethality
NOT5 YPR072W Component of the CCR4-NOT core complex, involved in mRNA decapping physical 1 1 1 Two-hybrid
CBF1 YJR060W Basic helix-loop-helix (bHLH) protein genetic 1 1 1 Negative Genetic
PHO4 YFR034C Basic helix-loop-helix (bHLH) transcription factor of the myc-family genetic 1 1 1 Synthetic Lethality
RPS1A YLR441C Ribosomal protein of the small (40S) subunit physical 1 1 1 Affinity Capture-MS
RPS8A YBL072C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS8A YBL072C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Synthetic Lethality
RPS17A YML024W Ribosomal protein 51 (rp51) of the small (40s) subunit physical 1 1 1 Affinity Capture-MS
RPS17B YDR447C Ribosomal protein 51 (rp51) of the small (40s) subunit genetic 1 1 1 Synthetic Lethality
RPS1B YML063W Ribosomal protein of the small (40S) subunit genetic 1 1 1 Synthetic Lethality
RPS7A YOR096W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Synthetic Lethality
RPL22A YLR061W Ribosomal 60S subunit protein L22A genetic 1 1 1 Positive Genetic
RPS22A YJL190C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
APN1 YKL114C Major apurinic/apyrimidinic endonuclease genetic 1 1 1 Synthetic Lethality
CPT1 YNL130C Cholinephosphotransferase genetic 1 1 1 Synthetic Lethality
PLC1 YPL268W Phospholipase C genetic 1 1 1 Synthetic Lethality
ALF1 YNL148C Alpha-tubulin folding protein genetic 1 1 1 Negative Genetic
BFR1 YOR198C Component of mRNP complexes associated with polyribosomes physical 1 1 1 Two-hybrid
BUD4 YJR092W Anillin-like protein involved in bud-site selection genetic 1 1 1 Synthetic Lethality
CLB5 YPR120C B-type cyclin involved in DNA replication during S phase genetic 1 1 1 Synthetic Lethality
CTF8 YHR191C Subunit of a complex with Ctf18p genetic 1 1 1 Synthetic Lethality
DCD1 YHR144C Deoxycytidine monophosphate (dCMP) deaminase genetic 1 1 1 Negative Genetic
GIM4 YEL003W Subunit of the heterohexameric cochaperone prefoldin complex genetic 1 1 1 Positive Genetic
HSP150 YJL159W O-mannosylated heat shock protein genetic 1 1 1 Synthetic Lethality
MPS1 YDL028C Dual-specificity kinase genetic 1 1 1 Positive Genetic
PHO80 YOL001W Cyclin genetic 1 1 1 Negative Genetic
RPA14 YDR156W RNA polymerase I subunit A14 genetic 1 1 1 Synthetic Lethality
SAS2 YMR127C Histone acetyltransferase (HAT) catalytic subunit of the SAS complex genetic 1 1 1 Synthetic Lethality
ERV41 YML067C Protein localized to COPII-coated vesicles genetic 1 1 1 Synthetic Lethality
SEC22 YLR268W R-SNARE protein genetic 1 1 1 Positive Genetic
RAP1 YNL216W Essential DNA-binding transcription regulator that binds many loci physical 1 1 1 Affinity Capture-Western
RCY1 YJL204C F-box protein involved in recycling endocytosed proteins genetic 1 1 1 Synthetic Lethality
SSN3 YPL042C Component of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
SRO7 YPR032W Effector of Rab GTPase Sec4p genetic 1 1 1 Negative Genetic
STU1 YBL034C Microtubule plus-end-tracking non-motor protein genetic 1 1 1 Negative Genetic
JNM1 YMR294W Component of the yeast dynactin complex genetic 1 1 1 Synthetic Lethality
SFI1 YLL003W Centrin (Cdc31p)-binding protein required for SPB duplication genetic 1 1 1 Synthetic Lethality
HSF1 YGL073W Trimeric heat shock transcription factor genetic 1 1 1 Synthetic Lethality
KAR2 YJL034W ATPase involved in protein import into the ER physical 1 1 1 Two-hybrid
SIL1 YOL031C Nucleotide exchange factor for the ER lumenal Hsp70 chaperone Kar2p genetic 1 1 1 Synthetic Lethality
SML1 YML058W Ribonucleotide reductase inhibitor genetic 1 1 1 Synthetic Lethality
POL3 YDL102W Catalytic subunit of DNA polymerase delta genetic 1 1 1 Synthetic Lethality
POL31 YJR006W Subunit of DNA polymerase delta (polymerase III) genetic 1 1 1 Negative Genetic
FBP1 YLR377C Fructose-1,6-bisphosphatase genetic 1 1 1 Synthetic Lethality
SPT10 YJL127C Histone H3 acetylase with a role in transcriptional regulation physical 1 1 1 Affinity Capture-MS
SPT10 YJL127C Histone H3 acetylase with a role in transcriptional regulation genetic 1 1 1 Synthetic Lethality
CAF16 YFL028C Part of evolutionarily-conserved CCR4-NOT regulatory complex genetic 1 1 1 Synthetic Lethality
ESC2 YDR363W Sumo-like domain protein genetic 1 1 1 Synthetic Lethality
GTS1 YGL181W Protein involved in Arf3p regulation and in transcription regulation genetic 1 1 1 Negative Genetic
JEM1 YJL073W DnaJ-like chaperone required for nuclear membrane fusion during mating genetic 1 1 1 Synthetic Lethality
LRG1 YDL240W GTPase-activating protein (GAP) genetic 1 1 1 Synthetic Lethality
GNT1 YOR320C N-acetylglucosaminyltransferase genetic 1 1 1 Synthetic Lethality
ATC1 YDR184C Nuclear protein genetic 1 1 1 Synthetic Lethality
COQ1 YBR003W Hexaprenyl pyrophosphate synthetase genetic 1 1 1 Synthetic Lethality
CDC19 YAL038W Pyruvate kinase genetic 1 1 1 Negative Genetic
MON1 YGL124C Subunit of a heterodimeric guanine nucleotide exchange factor (GEF) genetic 1 1 1 Negative Genetic
PET309 YLR067C Specific translational activator for the COX1 mRNA genetic 1 1 1 Synthetic Lethality
PET494 YNR045W Mitochondrial translational activator specific for the COX3 mRNA genetic 1 1 1 Negative Genetic
CMR2 YOR093C Putative protein of unknown function genetic 1 1 1 Synthetic Lethality
RGD2 YFL047W GTPase-activating protein (RhoGAP) for Cdc42p and Rho5p genetic 1 1 1 Synthetic Lethality
RGA2 YDR379W GTPase-activating protein for polarity-establishment protein Cdc42p genetic 1 1 1 Synthetic Lethality
SPC25 YER018C Component of the kinetochore-associated Ndc80 complex genetic 1 1 1 Synthetic Lethality
MRI1 YPR118W 5'-methylthioribose-1-phosphate isomerase genetic 1 1 1 Synthetic Lethality
STU2 YLR045C Microtubule polymerase of the XMAP215/Dis1 family genetic 1 1 1 Synthetic Lethality
SCW4 YGR279C Cell wall protein with similarity to glucanases genetic 1 1 1 Synthetic Lethality
MSB4 YOL112W GTPase-activating protein of the Ras superfamily genetic 1 1 1 Synthetic Lethality
NIP100 YPL174C Large subunit of the dynactin complex physical 1 1 1 Two-hybrid
NIP100 YPL174C Large subunit of the dynactin complex genetic 1 1 1 Negative Genetic
GTT2 YLL060C Glutathione S-transferase capable of homodimerization genetic 1 1 1 Synthetic Lethality
RPL25 YOL127W Ribosomal 60S subunit protein L25 physical 1 1 1 Affinity Capture-MS
RPL31A YDL075W Ribosomal 60S subunit protein L31A physical 1 1 1 Affinity Capture-MS
REV3 YPL167C Catalytic subunit of DNA polymerase zeta physical 1 1 1 Affinity Capture-MS
LRS4 YDR439W Nucleolar protein that forms a complex with Csm1p genetic 1 1 1 Synthetic Lethality
CQD1 YPL109C UbiB family mitochondrial protein genetic 1 1 1 Synthetic Lethality
PRI1 YIR008C Subunit of DNA primase genetic 1 1 1 Negative Genetic
HHT2 YNL031C Histone H3 physical 1 1 1 Affinity Capture-MS
APN2 YBL019W Class II abasic (AP) endonuclease involved in repair of DNA damage genetic 1 1 1 Synthetic Lethality
ASH1 YKL185W Component of the Rpd3L histone deacetylase complex physical 1 1 1 Co-localization
ASH1 YKL185W Component of the Rpd3L histone deacetylase complex genetic 1 1 1 Phenotypic Suppression
ERV29 YGR284C Protein localized to COPII-coated vesicles genetic 1 1 1 Synthetic Lethality
BCS1 YDR375C Protein translocase and chaperone required for Complex III assembly genetic 1 1 1 Synthetic Lethality
OXA1 YER154W Mitochondrial inner membrane insertase genetic 1 1 1 Synthetic Lethality
SHE9 YDR393W Protein required for normal mitochondrial morphology genetic 1 1 1 Negative Genetic
RPS2 YGL123W Protein component of the small (40S) subunit physical 1 1 1 Affinity Capture-MS
RPS3 YNL178W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
HAC1 YFL031W Basic leucine zipper (bZIP) transcription factor (ATF/CREB1 homolog) genetic 1 1 1 Synthetic Lethality
MDL1 YLR188W Mitochondrial inner membrane half-type ABC transporter genetic 1 1 1 Synthetic Lethality
ENV11 YGR071C Protein proposed to be involved in vacuolar functions genetic 1 1 1 Negative Genetic
MNT4 YNR059W Putative alpha-1,3-mannosyltransferase genetic 1 1 1 Synthetic Lethality
ASN1 YPR145W Asparagine synthetase genetic 1 1 1 Synthetic Lethality
BET4 YJL031C Alpha subunit of Type II geranylgeranyltransferase genetic 1 1 1 Positive Genetic
RPL11A YPR102C Ribosomal 60S subunit protein L11A genetic 1 1 1 Negative Genetic
ARL3 YPL051W ARF-like small GTPase of the RAS superfamily genetic 1 1 1 Negative Genetic
DOM34 YNL001W Protein that facilitates ribosomal subunit dissociation genetic 1 1 1 Synthetic Lethality
RNR4 YGR180C Ribonucleotide-diphosphate reductase (RNR) small subunit genetic 1 1 1 Synthetic Lethality
RPN4 YDL020C Transcription factor that stimulates expression of proteasome genes genetic 1 1 1 Negative Genetic
EAF6 YJR082C Subunit of the NuA4 acetyltransferase complex physical 1 1 1 Two-hybrid
COX19 YLL018C-A Protein required for cytochrome c oxidase assembly genetic 1 1 1 Synthetic Lethality
EAF7 YNL136W Subunit of the NuA4 histone acetyltransferase complex genetic 1 1 1 Synthetic Lethality
NOP8 YOL144W Nucleolar protein required for 60S ribosomal subunit biogenesis genetic 1 1 1 Synthetic Lethality
RPS20 YHL015W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS23B YPR132W Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit genetic 1 1 1 Synthetic Lethality
RRS1 YOR294W Essential protein that binds ribosomal protein L11 genetic 1 1 1 Synthetic Lethality
RPS14A YCR031C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
MLS1 YNL117W Malate synthase, enzyme of the glyoxylate cycle genetic 1 1 1 Synthetic Lethality
RPL15A YLR029C Ribosomal 60S subunit protein L15A genetic 1 1 1 Negative Genetic
RPL27B YDR471W Ribosomal 60S subunit protein L27B genetic 1 1 1 Negative Genetic
RPS0A YGR214W Ribosomal 40S subunit protein S0A genetic 1 1 1 Synthetic Lethality
RPS18A YDR450W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
SBE22 YHR103W Protein involved in bud growth genetic 1 1 1 Synthetic Lethality
EUC1 YMR111C Sequence-specific DNA binding protein genetic 1 1 1 Synthetic Lethality
MIT1 YEL007W Transcriptional regulator of pseudohyphal growth genetic 1 1 1 Synthetic Lethality
PRP24 YMR268C Splicing factor that reanneals snRNPs during spliceosome recycling genetic 1 1 1 Negative Genetic
PDS5 YMR076C Cohesion maintenance factor genetic 1 1 1 Synthetic Lethality
MEU1 YLR017W Methylthioadenosine phosphorylase (MTAP) genetic 1 1 1 Synthetic Lethality
COY1 YKL179C Golgi membrane protein with similarity to mammalian CASP physical 1 1 1 Two-hybrid
CNN1 YFR046C Kinetochore protein genetic 1 1 1 Synthetic Lethality
HCM1 YCR065W Forkhead transcription factor genetic 1 1 1 Synthetic Lethality
ARR3 YPR201W Plasma membrane metalloid/H+ antiporter genetic 1 1 1 Synthetic Lethality
ASG7 YJL170C Protein that regulates signaling from G protein beta subunit Ste4p genetic 1 1 1 Synthetic Lethality
BNS1 YGR230W Protein of unknown function genetic 1 1 1 Synthetic Lethality
GTB1 YDR221W Glucosidase II beta subunit, forms a complex with alpha subunit Rot2p physical 1 1 1 Two-hybrid
SMN1 YHR202W Putative AMP hydrolase genetic 1 1 1 Synthetic Lethality
GAT2 YMR136W Protein containing GATA family zinc finger motifs genetic 1 1 1 Synthetic Lethality
RMI1 YPL024W Subunit of the RecQ (Sgs1p) - Topo III (Top3p) complex genetic 1 1 1 Synthetic Lethality
PAM17 YKR065C Constituent of the TIM23 complex genetic 1 1 1 Synthetic Lethality
RPL40A YIL148W Ubiquitin-ribosomal 60S subunit protein L40A fusion protein genetic 1 1 1 Synthetic Lethality
RPL40B YKR094C Ubiquitin-ribosomal 60S subunit protein L40B fusion protein genetic 1 1 1 Synthetic Lethality
RPS31 YLR167W Fusion protein cleaved to yield ribosomal protein S31 and ubiquitin genetic 1 1 1 Synthetic Lethality
FAT1 YBR041W Very long chain fatty acyl-CoA synthetase and fatty acid transporter genetic 1 1 1 Synthetic Lethality
HSK3 YKL138C-A Essential subunit of the Dam1 complex (aka DASH complex) physical 1 1 1 Two-hybrid
NTO1 YPR031W Subunit of the NuA3 histone acetyltransferase complex genetic 1 1 1 Synthetic Lethality
SWD3 YBR175W Essential subunit of the COMPASS (Set1C) complex genetic 1 1 1 Synthetic Lethality
AYT1 YLL063C Acetyltransferase genetic 1 1 1 Synthetic Lethality
NFS1 YCL017C Cysteine desulfurase involved in iron-sulfur cluster biogenesis genetic 1 1 1 Negative Genetic
SOL2 YCR073W-A Protein with a possible role in tRNA export genetic 1 1 1 Synthetic Lethality
PUS9 YDL036C Mitochondrial tRNA:pseudouridine synthase genetic 1 1 1 Synthetic Lethality
NTH1 YDR001C Neutral trehalase, degrades trehalose genetic 1 1 1 Synthetic Lethality
RPS10B YMR230W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
PAM1 YDR251W Essential protein of unknown function physical 1 1 1 Two-hybrid
PUF4 YGL014W Member of the PUF protein family physical 1 1 1 Affinity Capture-RNA
MRPL17 YNL252C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Synthetic Lethality
IRC22 YEL001C Protein of unknown function genetic 1 1 1 Synthetic Lethality
SLX8 YER116C Subunit of Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex genetic 1 1 1 Negative Genetic
MET10 YFR030W Subunit alpha of assimilatory sulfite reductase genetic 1 1 1 Synthetic Lethality
GEP7 YGL057C Protein of unknown function genetic 1 1 1 Synthetic Lethality
PMR1 YGL167C High affinity Ca2+/Mn2+ P-type ATPase genetic 1 1 1 Negative Genetic
ATG32 YIL146C Mitochondrial outer membrane protein required to initiate mitophagy genetic 1 1 1 Negative Genetic
PPT1 YGR123C Protein serine/threonine phosphatase genetic 1 1 1 Synthetic Lethality
NKP2 YLR315W Central kinetochore protein and subunit of the Ctf19 complex physical 1 1 1 Two-hybrid
MVB12 YGR206W ESCRT-I subunit required to stabilize ESCRT-I core complex oligomers genetic 1 1 1 Synthetic Lethality
IRC3 YDR332W Double-stranded DNA-dependent helicase of the DExH/D-box family genetic 1 1 1 Synthetic Lethality
BIO2 YGR286C Biotin synthase genetic 1 1 1 Synthetic Lethality
MRP35 YNL122C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Synthetic Lethality
NDT80 YHR124W Meiosis-specific transcription factor genetic 1 1 1 Synthetic Lethality
SEC28 YIL076W Epsilon-COP subunit of the coatomer genetic 1 1 1 Negative Genetic
ADH7 YCR105W NADPH-dependent medium chain alcohol dehydrogenase genetic 1 1 1 Synthetic Lethality
FUN14 YAL008W Integral mitochondrial outer membrane (MOM) protein genetic 1 1 1 Synthetic Lethality
SSH1 YBR283C Subunit of the Ssh1 translocon complex genetic 1 1 1 Negative Genetic
CGI121 YML036W Component of the EKC/KEOPS complex genetic 1 1 1 Synthetic Lethality
RPL37A YLR185W Ribosomal 60S subunit protein L37A genetic 1 1 1 Synthetic Lethality
MBR1 YKL093W Protein involved in mitochondrial functions and stress response genetic 1 1 1 Synthetic Lethality
CWP2 YKL096W-A Covalently linked cell wall mannoprotein genetic 1 1 1 Synthetic Lethality
SBA1 YKL117W Co-chaperone that binds and regulates Hsp90 family chaperones physical 1 1 1 Two-hybrid
FMP46 YKR049C Putative redox protein containing a thioredoxin fold genetic 1 1 1 Synthetic Lethality
RTT109 YLL002W Histone acetyltransferase genetic 1 1 1 Synthetic Lethality
MSS51 YLR203C Specific translational activator for the mitochondrial COX1 mRNA genetic 1 1 1 Synthetic Lethality
GCV3 YAL044C H subunit of the mitochondrial glycine decarboxylase complex genetic 1 1 1 Synthetic Lethality
BIL1 YOR304C-A Protein that binds Bud6p and has a role in actin cable assembly physical 1 1 1 Two-hybrid
NQM1 YGR043C Transaldolase of unknown function genetic 1 1 1 Synthetic Lethality
AIM26 YKL037W Protein of unknown function genetic 1 1 1 Negative Genetic
FRD1 YEL047C Soluble fumarate reductase genetic 1 1 1 Synthetic Lethality
POC4 YPL144W Component of a heterodimeric Poc4p-Irc25p chaperone genetic 1 1 1 Synthetic Lethality
GIS2 YNL255C Translational activator for mRNAs with internal ribosome entry sites genetic 1 1 1 Synthetic Lethality
LAG2 YOL025W Protein that negatively regulates the SCF E3-ubiquitin ligase genetic 1 1 1 Synthetic Lethality
GLN4 YOR168W Glutamine tRNA synthetase genetic 1 1 1 Synthetic Lethality
SAS5 YOR213C Subunit of the SAS complex (Sas2p, Sas4p, Sas5p) genetic 1 1 1 Synthetic Lethality
SYH1 YPL105C Protein of unknown function that influences nuclear pore distribution genetic 1 1 1 Synthetic Lethality
RPS6A YPL090C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS6A YPL090C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Synthetic Lethality
ALT1 YLR089C Alanine transaminase (glutamic pyruvic transaminase) genetic 1 1 1 Negative Genetic
OGG1 YML060W Nuclear and mitochondrial glycosylase/lyase genetic 1 1 1 Synthetic Lethality
RPS9A YPL081W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RRG8 YPR116W Protein of unknown function genetic 1 1 1 Synthetic Lethality
RRG1 YDR065W Protein of unknown function genetic 1 1 1 Synthetic Lethality
RPS22B YLR367W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Synthetic Lethality
SEH1 YGL100W Subunit of the Nup84 nuclear pore and SEACAT subcomplexes genetic 1 1 1 Synthetic Lethality
RPS16A YMR143W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Synthetic Lethality
MPA43 YNL249C Protein of unknown function genetic 1 1 1 Synthetic Lethality
RPL35A YDL191W Ribosomal 60S subunit protein L35A genetic 1 1 1 Synthetic Lethality
MIL1 YFL034W Predicted lipase genetic 1 1 1 Synthetic Lethality
RPL43A YPR043W Ribosomal 60S subunit protein L43A genetic 1 1 1 Synthetic Lethality
RSA3 YLR221C Protein with a likely role in ribosomal maturation genetic 1 1 1 Synthetic Lethality
NHA1 YLR138W Na+/H+ antiporter genetic 1 1 1 Synthetic Lethality
SLD5 YDR489W Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) genetic 1 1 1 Negative Genetic
RPL36A YMR194W Ribosomal 60S subunit protein L36A genetic 1 1 1 Synthetic Lethality
LDB7 YBL006C Component of the RSC chromatin remodeling complex genetic 1 1 1 Synthetic Lethality
RPL26A YLR344W Ribosomal 60S subunit protein L26A physical 1 1 1 Affinity Capture-MS
RPL34A YER056C-A Ribosomal 60S subunit protein L34A genetic 1 1 1 Synthetic Lethality
RPS19B YNL302C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Synthetic Lethality
RPS19A YOL121C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
APJ1 YNL077W Hsp40 chaperone with a role in SUMO-mediated protein degradation physical 1 1 1 Affinity Capture-MS
ATG21 YPL100W Phosphoinositide binding protein genetic 1 1 1 Synthetic Lethality
CMK2 YOL016C Calmodulin-dependent protein kinase genetic 1 1 1 Synthetic Lethality
CAB1 YDR531W Pantothenate kinase, ATP:D-pantothenate 4'-phosphotransferase genetic 1 1 1 Negative Genetic
ARV1 YLR242C Cortical ER protein genetic 1 1 1 Negative Genetic
DFM1 YDR411C Endoplasmic reticulum (ER) localized protein genetic 1 1 1 Synthetic Lethality
ABM1 YJR108W Protein of unknown function genetic 1 1 1 Synthetic Lethality
DUS1 YML080W Dihydrouridine synthase genetic 1 1 1 Synthetic Lethality
PCM1 YEL058W Essential N-acetylglucosamine-phosphate mutase genetic 1 1 1 Synthetic Lethality
INP54 YOL065C Phosphatidylinositol 4,5-bisphosphate 5-phosphatase genetic 1 1 1 Synthetic Lethality
PSP1 YDR505C Asn and gln rich protein of unknown function physical 1 1 1 Two-hybrid
RNH70 YGR276C 3'-5' exoribonuclease genetic 1 1 1 Synthetic Lethality
RGD3 YHR182W GTPase activating protein (GAP) for Rho3p, involved in cell polarity g genetic 1 1 1 Synthetic Lethality
SKS1 YPL026C Putative serine/threonine protein kinase physical 1 1 1 Two-hybrid
RUD3 YOR216C Golgi matrix protein physical 1 1 1 Two-hybrid
SCH9 YHR205W AGC family protein kinase genetic 1 1 1 Negative Genetic
PRM10 YJL108C Pheromone-regulated protein genetic 1 1 1 Synthetic Lethality
SUB1 YMR039C Transcriptional regulator genetic 1 1 1 Synthetic Lethality
CHS7 YHR142W Protein of unknown function genetic 1 1 1 Synthetic Lethality
STF2 YGR008C Protein involved in resistance to desiccation stress genetic 1 1 1 Synthetic Lethality
SCD6 YPR129W Repressor of translation initiation genetic 1 1 1 Synthetic Lethality
SLM5 YCR024C Mitochondrial asparaginyl-tRNA synthetase genetic 1 1 1 Synthetic Lethality
STE3 YKL178C Receptor for a factor pheromone genetic 1 1 1 Synthetic Lethality
RPS18B YML026C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Synthetic Lethality
NCR1 YPL006W Vacuolar membrane protein involved with Npc2p in sterol trafficking genetic 1 1 1 Negative Genetic
MTM1 YGR257C Mitochondrial protein of the mitochondrial carrier family genetic 1 1 1 Synthetic Lethality
RSM27 YGR215W Mitochondrial ribosomal protein of the small subunit genetic 1 1 1 Synthetic Lethality
RAD57 YDR004W Protein that stimulates strand exchange genetic 1 1 1 Synthetic Lethality
RPS27A YKL156W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPL14A YKL006W Ribosomal 60S subunit protein L14A genetic 1 1 1 Negative Genetic
RPL15B YMR121C Ribosomal 60S subunit protein L15B genetic 1 1 1 Synthetic Lethality
RRT2 YBR246W Methylesterase performing penultimate step of diphthamide biosynthesis genetic 1 1 1 Synthetic Lethality
MRX18 YBR056W Putative glycoside hydrolase of the mitochondrial intermembrane space genetic 1 1 1 Synthetic Lethality
CPD1 YGR247W Cyclic nucleotide phosphodiesterase genetic 1 1 1 Synthetic Lethality
JJJ3 YJR097W Iron-binding protein genetic 1 1 1 Synthetic Lethality
ASI2 YNL159C Subunit of the inner nuclear membrane Asi ubiquitin ligase complex genetic 1 1 1 Synthetic Lethality
RDL1 YOR285W Thiosulfate sulfurtransferase genetic 1 1 1 Synthetic Lethality
RCR1 YBR005W Plasma membrane (PM) ubiquitin ligase-substrate adaptor genetic 1 1 1 Synthetic Lethality
NTG2 YOL043C DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase genetic 1 1 1 Synthetic Lethality
MPS3 YJL019W Nuclear envelope protein genetic 1 1 1 Synthetic Lethality
HXT3 YDR345C Low affinity glucose transporter of the major facilitator superfamily genetic 1 1 1 Synthetic Lethality
SNQ2 YDR011W Plasma membrane ATP-binding cassette (ABC) transporter genetic 1 1 1 Synthetic Lethality
DFG16 YOR030W Probable multiple transmembrane protein genetic 1 1 1 Synthetic Lethality
MFG1 YDL233W Regulator of filamentous growth genetic 1 1 1 Synthetic Lethality
SOK2 YMR016C Nuclear protein that negatively regulates pseudohyphal differentiation genetic 1 1 1 Synthetic Lethality
SAD1 YFR005C Conserved zinc-finger domain protein involved in pre-mRNA splicing genetic 1 1 1 Negative Genetic
MUP1 YGR055W High affinity methionine permease genetic 1 1 1 Synthetic Lethality
SHR3 YDL212W Endoplasmic reticulum packaging chaperone genetic 1 1 1 Synthetic Lethality
ILM1 YJR118C Protein of unknown function genetic 1 1 1 Synthetic Lethality
RIB5 YBR256C Riboflavin synthase genetic 1 1 1 Synthetic Lethality
ERP4 YOR016C Member of the p24 family involved in ER to Golgi transport genetic 1 1 1 Negative Genetic
FRM2 YCL026C-A Type II nitroreductase, using NADH as reductant genetic 1 1 1 Synthetic Lethality
CPR4 YCR069W Peptidyl-prolyl cis-trans isomerase (cyclophilin) genetic 1 1 1 Synthetic Lethality
MAL13 YGR288W MAL-activator protein genetic 1 1 1 Synthetic Lethality
FMP25 YLR077W Protein required for assembly of respiratory complex III genetic 1 1 1 Synthetic Lethality
SIC1 YLR079W Cyclin-dependent kinase inhibitor (CKI) genetic 1 1 1 Synthetic Lethality
HER2 YMR293C Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex genetic 1 1 1 Synthetic Lethality
DYN3 YMR299C Dynein light intermediate chain (LIC) genetic 1 1 1 Negative Genetic
SHR5 YOL110W Palmitoyltransferase subunit genetic 1 1 1 Synthetic Lethality
KRE1 YNL322C Cell wall glycoprotein involved in beta-glucan assembly genetic 1 1 1 Synthetic Lethality
MRN1 YPL184C RNA-binding protein that may be involved in translational regulation genetic 1 1 1 Negative Genetic
PHO92 YDR374C Posttranscriptional regulator of phosphate and glucose metabolism genetic 1 1 1 Negative Genetic
ALG2 YGL065C Mannosyltransferase in the N-linked glycosylation pathway genetic 1 1 1 Negative Genetic
KTR7 YIL085C Putative mannosyltransferase involved in protein glycosylation genetic 1 1 1 Negative Genetic
LCB3 YJL134W Long-chain base-1-phosphate phosphatase genetic 1 1 1 Synthetic Lethality
MRX12 YJR003C Protein that associates with mitochondrial ribosome genetic 1 1 1 Synthetic Lethality
CDC8 YJR057W Nucleoside monophosphate and nucleoside diphosphate kinase genetic 1 1 1 Negative Genetic
AVL9 YLR114C Conserved protein involved in exocytic transport from the Golgi genetic 1 1 1 Synthetic Lethality
ALG9 YNL219C Mannosyltransferase, involved in N-linked glycosylation genetic 1 1 1 Synthetic Lethality
PFA4 YOL003C Palmitoyltransferase with autoacylation activity genetic 1 1 1 Negative Genetic
EDC1 YGL222C RNA-binding protein that activates mRNA decapping directly genetic 1 1 1 Synthetic Lethality
HAL1 YPR005C Cytoplasmic protein involved in halotolerance genetic 1 1 1 Synthetic Lethality
SMF3 YLR034C Putative divalent metal ion transporter involved in iron homeostasis genetic 1 1 1 Synthetic Lethality
MPC3 YGR243W Highly conserved subunit of the mitochondrial pyruvate carrier (MPC) genetic 1 1 1 Synthetic Lethality
SPT21 YMR179W Protein with a role in transcriptional silencing genetic 1 1 1 Synthetic Lethality
ROQ1 YJL144W Ub-ligase substrate-specificity factor genetic 1 1 1 Negative Genetic
MTO1 YGL236C Mitochondrial protein genetic 1 1 1 Synthetic Lethality
PFD1 YJL179W Subunit of heterohexameric prefoldin physical 1 1 1 Two-hybrid
RPO41 YFL036W Mitochondrial RNA polymerase genetic 1 1 1 Synthetic Lethality
FAU1 YER183C 5,10-methenyltetrahydrofolate synthetase genetic 1 1 1 Synthetic Lethality
LSC2 YGR244C Beta subunit of succinyl-CoA ligase genetic 1 1 1 Synthetic Lethality
DPC25 YPL107W Putative mitochondrial protein of unknown function genetic 1 1 1 Synthetic Lethality
MAL11 YGR289C High-affinity maltose transporter (alpha-glucoside transporter) genetic 1 1 1 Synthetic Lethality
MCP1 YOR228C Mitochondrial protein of unknown function involved in lipid homeostas genetic 1 1 1 Synthetic Lethality
ECM4 YKR076W S-glutathionyl-(chloro)hydroquinone reductase (GS-HQR) genetic 1 1 1 Synthetic Lethality
FYV7 YLR068W Nucleolar protein required for maturation of 18S rRNA genetic 1 1 1 Synthetic Lethality
MAL33 YBR297W MAL-activator protein genetic 1 1 1 Synthetic Lethality
HBN1 YCL026C-B Protein of unknown function genetic 1 1 1 Negative Genetic
MCT1 YOR221C Predicted malonyl-CoA:ACP transferase genetic 1 1 1 Synthetic Lethality
MCO6 YJL127C-B Mitochondrial protein of unknown function genetic 1 1 1 Synthetic Lethality
DIT2 YDR402C N-formyltyrosine oxidase genetic 1 1 1 Synthetic Lethality
ECM34 YHL043W Protein of unknown function genetic 1 1 1 Negative Genetic
LDO16 YMR148W Protein of unknown function with possible role in spore wall assembly genetic 1 1 1 Synthetic Lethality
ICL2 YPR006C 2-methylisocitrate lyase of the mitochondrial matrix genetic 1 1 1 Synthetic Lethality
DFR1 YOR236W Dihydrofolate reductase involved in tetrahydrofolate biosynthesis genetic 1 1 1 Synthetic Lethality
PMP3 YDR276C Small plasma membrane protein genetic 1 1 1 Synthetic Lethality
PMP2 YEL017C-A Proteolipid associated with plasma membrane H(+)-ATPase (Pma1p) genetic 1 1 1 Synthetic Lethality
JEN1 YKL217W Monocarboxylate/proton symporter of the plasma membrane genetic 1 1 1 Synthetic Lethality
MMM1 YLL006W ER integral membrane protein, ERMES complex subunit genetic 1 1 1 Positive Genetic
OPT2 YPR194C Oligopeptide transporter genetic 1 1 1 Synthetic Lethality
RPS15 YOL040C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
CIT3 YPR001W Dual specificity mitochondrial citrate and methylcitrate synthase genetic 1 1 1 Synthetic Lethality
IMA1 YGR287C Major isomaltase (alpha-1,6-glucosidase/alpha-methylglucosidase) genetic 1 1 1 Synthetic Lethality
PEX35 YGR168C Regulator of peroxisome abundance genetic 1 1 1 Negative Genetic
SLD3 YGL113W Protein involved in the initiation of DNA replication genetic 1 1 1 Negative Genetic
AIM36 YMR157C Protein of unknown function genetic 1 1 1 Negative Genetic
RCF1 YML030W Cytochrome c oxidase subunit physical 1 1 1 Two-hybrid
PUT1 YLR142W Proline oxidase genetic 1 1 1 Synthetic Lethality
SEC12 YNR026C Guanine nucleotide exchange factor (GEF) genetic 1 1 1 Negative Genetic
PDR18 YNR070W Transporter of the ATP-binding cassette (ABC) family genetic 1 1 1 Synthetic Lethality
SRP72 YPL210C Core component of the signal recognition particle (SRP) genetic 1 1 1 Synthetic Lethality
STB6 YKL072W Protein that binds Sin3p in a two-hybrid assay genetic 1 1 1 Synthetic Lethality
HMI1 YOL095C Mitochondrial inner membrane localized ATP-dependent DNA helicase genetic 1 1 1 Synthetic Lethality
RPS30A YLR287C-A Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
CWP1 YKL096W Cell wall mannoprotein that localizes to birth scars of daughter cells genetic 1 1 1 Synthetic Lethality
ICE2 YIL090W Integral ER membrane protein with type-III transmembrane domains genetic 1 1 1 Synthetic Lethality
TAD1 YGL243W tRNA-specific adenosine deaminase genetic 1 1 1 Synthetic Lethality
GPI11 YDR302W ER membrane protein involved in a late step of GPI anchor assembly genetic 1 1 1 Synthetic Lethality
DBR1 YKL149C RNA lariat debranching enzyme genetic 1 1 1 Synthetic Lethality
HPM1 YIL110W AdoMet-dependent methyltransferase genetic 1 1 1 Negative Genetic
SEN34 YAR008W Subunit of the tRNA splicing endonuclease genetic 1 1 1 Synthetic Lethality
ODC2 YOR222W Mitochondrial inner membrane transporter genetic 1 1 1 Synthetic Lethality
RME1 YGR044C Zinc finger protein involved in control of meiosis genetic 1 1 1 Synthetic Lethality
SHQ1 YIL104C Chaperone protein genetic 1 1 1 Synthetic Lethality
SSP120 YLR250W Protein packaged into COPII vesicles for ER to Golgi trafficking genetic 1 1 1 Synthetic Lethality
SLH1 YGR271W Subunit of ribosome-associated quality control trigger complex (RQT) genetic 1 1 1 Synthetic Lethality
DML1 YMR211W Essential protein involved in mtDNA inheritance genetic 1 1 1 Synthetic Lethality
MMT1 YMR177W Putative metal transporter involved in mitochondrial iron accumulation genetic 1 1 1 Synthetic Lethality
SPF1 YEL031W P-type ATPase, ion transporter of the ER membrane genetic 1 1 1 Negative Genetic
DAN1 YJR150C Cell wall mannoprotein genetic 1 1 1 Synthetic Lethality
SPO22 YIL073C Meiosis-specific protein essential for chromosome synapsis genetic 1 1 1 Synthetic Lethality
MNE1 YOR350C Protein involved in splicing Group I aI5-beta intron from COX1 mRNA genetic 1 1 1 Synthetic Lethality
SSP2 YOR242C Sporulation specific protein that localizes to the spore wall genetic 1 1 1 Synthetic Lethality
PAU13 YHL046C Protein of unknown function genetic 1 1 1 Synthetic Lethality
SAY1 YGR263C Sterol deacetylase genetic 1 1 1 Synthetic Lethality
RKM2 YDR198C Ribosomal protein lysine methyltransferase genetic 1 1 1 Synthetic Lethality
SEC59 YMR013C Dolichol kinase genetic 1 1 1 Synthetic Lethality
TAD3 YLR316C Subunit of tRNA-specific adenosine-34 deaminase genetic 1 1 1 Negative Genetic
RTC5 YOR118W Protein of unknown function genetic 1 1 1 Synthetic Lethality
MAN2 YNR073C Mannitol dehydrogenase genetic 1 1 1 Synthetic Lethality