URB2 |
YJR041C |
Protein required for normal metabolism of the rRNA primary transcript |
physical |
8 |
4 |
4 |
Affinity Capture-MS, Affinity Capture-Western, Two-hybrid, Two-hybrid, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Co-purification |
URB1 |
YKL014C |
Protein required for the normal accumulation of 25S and 5.8S rRNAs |
physical |
5 |
4 |
3 |
Affinity Capture-MS, Two-hybrid, Two-hybrid, Affinity Capture-Western, Co-purification |
NOP8 |
YOL144W |
Nucleolar protein required for 60S ribosomal subunit biogenesis |
physical |
5 |
3 |
3 |
Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Co-purification |
CKB1 |
YGL019W |
Beta regulatory subunit of casein kinase 2 (CK2) |
genetic |
5 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
CKB2 |
YOR039W |
Beta' regulatory subunit of casein kinase 2 (CK2) |
genetic |
5 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
YCR016W |
YCR016W |
Putative protein of unknown function |
genetic |
5 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
PIH1 |
YHR034C |
Component of the conserved R2TP complex (Rvb1-Rvb2-Tah1-Pih1) |
genetic |
4 |
2 |
3 |
Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect |
SSF1 |
YHR066W |
Constituent of 66S pre-ribosomal particles |
genetic |
4 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
DBP6 |
YNR038W |
Essential protein involved in ribosome biogenesis |
genetic |
3 |
2 |
3 |
Synthetic Lethality, Negative Genetic, Negative Genetic |
MAK21 |
YDR060W |
Constituent of 66S pre-ribosomal particles |
physical |
3 |
1 |
3 |
Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS |
RVB2 |
YPL235W |
ATP-dependent DNA helicase, also known as reptin |
genetic |
3 |
2 |
2 |
Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect |
RRP6 |
YOR001W |
Nuclear exosome exonuclease component |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
NEW1 |
YPL226W |
Translation termination and ribosome biogenesis factor |
genetic |
3 |
1 |
2 |
Positive Genetic, Positive Genetic, Positive Genetic |
THR4 |
YCR053W |
Threonine synthase |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
SSD1 |
YDR293C |
Translational repressor |
genetic |
3 |
1 |
2 |
Positive Genetic, Positive Genetic, Positive Genetic |
URB2 |
YJR041C |
Protein required for normal metabolism of the rRNA primary transcript |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Negative Genetic |
DBP3 |
YGL078C |
RNA-Dependent ATPase, member of DExD/H-box family |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
FIP1 |
YJR093C |
Subunit of cleavage polyadenylation factor (CPF) |
physical |
2 |
1 |
2 |
Affinity Capture-MS, Affinity Capture-MS |
MPT5 |
YGL178W |
mRNA-binding protein of the PUF family |
physical |
2 |
1 |
2 |
Affinity Capture-RNA, Affinity Capture-RNA |
CSG2 |
YBR036C |
Endoplasmic reticulum membrane protein |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
DBP6 |
YNR038W |
Essential protein involved in ribosome biogenesis |
physical |
2 |
1 |
2 |
Affinity Capture-Western, Affinity Capture-Western |
RRP15 |
YPR143W |
Nucleolar protein |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
YML002W |
YML002W |
Putative protein of unknown function |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
BUB2 |
YMR055C |
Mitotic exit network regulator |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
EXO1 |
YOR033C |
5'-3' exonuclease and flap-endonuclease |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
TMA23 |
YMR269W |
Nucleolar protein implicated in ribosome biogenesis |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
FKH1 |
YIL131C |
Forkhead family transcription factor |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
SFP1 |
YLR403W |
Regulates transcription of ribosomal protein and biogenesis genes |
regulation |
1 |
1 |
1 |
DNA to cDNA expression microarray evidence |
RFX1 |
YLR176C |
Major transcriptional repressor of DNA-damage-regulated genes |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
STP1 |
YDR463W |
Transcription factor |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
CDC73 |
YLR418C |
Component of the Paf1p complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
IKI3 |
YLR384C |
Subunit of Elongator complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
NOP2 |
YNL061W |
rRNA m5C methyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
NOP4 |
YPL043W |
Nucleolar protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
RIC1 |
YLR039C |
Protein involved in retrograde transport to the cis-Golgi network |
genetic |
1 |
1 |
1 |
Negative Genetic |
RRP14 |
YKL082C |
Essential protein, constituent of 66S pre-ribosomal particles |
genetic |
1 |
1 |
1 |
Negative Genetic |
MRT4 |
YKL009W |
Protein involved in mRNA turnover and ribosome assembly |
genetic |
1 |
1 |
1 |
Positive Genetic |
NOP15 |
YNL110C |
Constituent of 66S pre-ribosomal particles |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
NOP58 |
YOR310C |
Protein involved in producing mature rRNAs and snoRNAs |
genetic |
1 |
1 |
1 |
Negative Genetic |
DBP7 |
YKR024C |
Putative ATP-dependent RNA helicase of the DEAD-box family |
genetic |
1 |
1 |
1 |
Negative Genetic |
RRP5 |
YMR229C |
RNA binding protein involved in synthesis of 18S and 5.8S rRNAs |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
PAT1 |
YCR077C |
Deadenylation-dependent mRNA-decapping factor |
genetic |
1 |
1 |
1 |
Positive Genetic |
LSM6 |
YDR378C |
Lsm (Like Sm) protein |
genetic |
1 |
1 |
1 |
Positive Genetic |
NOP1 |
YDL014W |
Histone glutamine methyltransferase, modifies H2A at Q105 in nucleolus |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
LRP1 |
YHR081W |
Nuclear exosome-associated nucleic acid binding protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
RPL3 |
YOR063W |
Ribosomal 60S subunit protein L3 |
genetic |
1 |
1 |
1 |
Negative Genetic |
RRB1 |
YMR131C |
Specific assembly chaperone for ribosomal protein Rpl3p |
genetic |
1 |
1 |
1 |
Negative Genetic |
RRP8 |
YDR083W |
Nucleolar S-adenosylmethionine-dependent rRNA methyltransferase |
genetic |
1 |
1 |
1 |
Positive Genetic |
NOP12 |
YOL041C |
Nucleolar protein involved in pre-25S rRNA processing |
genetic |
1 |
1 |
1 |
Negative Genetic |
CCR4 |
YAL021C |
Component of the CCR4-NOT transcriptional complex |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
NAM7 |
YMR080C |
ATP-dependent RNA helicase of the SFI superfamily |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
RNT1 |
YMR239C |
Nuclear dsRNA-specific ribonuclease (RNase III) |
genetic |
1 |
1 |
1 |
Negative Genetic |
LHP1 |
YDL051W |
RNA binding protein required for maturation of tRNA and U6 snRNA |
genetic |
1 |
1 |
1 |
Positive Genetic |
GCN1 |
YGL195W |
Positive regulator of the Gcn2p kinase activity |
genetic |
1 |
1 |
1 |
Positive Genetic |
DHH1 |
YDL160C |
Cytoplasmic DEAD-box helicase and mRNA decapping activator |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
KRR1 |
YCL059C |
Nucleolar protein required for rRNA synthesis and ribosomal assembly |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
MRH4 |
YGL064C |
Mitochondrial ATP-dependent RNA helicase of the DEAD-box family |
genetic |
1 |
1 |
1 |
Negative Genetic |
POP7 |
YBR167C |
Subunit of RNase MRP, nuclear RNase P and telomerase |
genetic |
1 |
1 |
1 |
Positive Genetic |
LEA1 |
YPL213W |
Component of U2 snRNP complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
PRE9 |
YGR135W |
Alpha 3 subunit of the 20S proteasome |
genetic |
1 |
1 |
1 |
Positive Genetic |
RAM1 |
YDL090C |
Beta subunit of the CAAX farnesyltransferase (FTase) |
genetic |
1 |
1 |
1 |
Negative Genetic |
RPB10 |
YOR210W |
RNA polymerase subunit ABC10-beta |
genetic |
1 |
1 |
1 |
Positive Genetic |
PHO23 |
YNL097C |
Component of the Rpd3L histone deacetylase complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
MAF1 |
YDR005C |
Highly conserved negative regulator of RNA polymerase III |
genetic |
1 |
1 |
1 |
Negative Genetic |
BRR1 |
YPR057W |
snRNP protein component of spliceosomal snRNPs |
genetic |
1 |
1 |
1 |
Positive Genetic |
CAM1 |
YPL048W |
One of two isoforms of the gamma subunit of eEF1B |
genetic |
1 |
1 |
1 |
Positive Genetic |
PUF3 |
YLL013C |
Protein of the mitochondrial outer surface |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
LSM12 |
YHR121W |
Protein of unknown function that may function in RNA processing |
genetic |
1 |
1 |
1 |
Positive Genetic |
BBC1 |
YJL020C |
Protein possibly involved in assembly of actin patches |
genetic |
1 |
1 |
1 |
Negative Genetic |
NOP6 |
YDL213C |
rRNA-binding protein required for 40S ribosomal subunit biogenesis |
genetic |
1 |
1 |
1 |
Positive Genetic |
HXT6 |
YDR343C |
High-affinity glucose transporter |
genetic |
1 |
1 |
1 |
Negative Genetic |
KAP122 |
YGL016W |
Karyopherin beta |
genetic |
1 |
1 |
1 |
Positive Genetic |
MAK11 |
YKL021C |
Protein involved in an early step of 60S ribosomal subunit biogenesis |
genetic |
1 |
1 |
1 |
Negative Genetic |
KSP1 |
YHR082C |
Serine/threonine protein kinase |
physical |
1 |
1 |
1 |
Biochemical Activity |
ARG1 |
YOL058W |
Arginosuccinate synthetase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
BIR1 |
YJR089W |
Subunit of chromosomal passenger complex (CPC) |
genetic |
1 |
1 |
1 |
Positive Genetic |
RPL5 |
YPL131W |
Ribosomal 60S subunit protein L5 |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
ESS1 |
YJR017C |
Peptidylprolyl-cis/trans-isomerase (PPIase) |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
MLP2 |
YIL149C |
Myosin-like protein associated with the nuclear envelope |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
IME2 |
YJL106W |
Serine/threonine protein kinase involved in activation of meiosis |
physical |
1 |
1 |
1 |
Biochemical Activity |
LEU4 |
YNL104C |
Alpha-isopropylmalate synthase (2-isopropylmalate synthase) |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RLP24 |
YLR009W |
Essential protein required for ribosomal large subunit biogenesis |
genetic |
1 |
1 |
1 |
Negative Genetic |
RPS17A |
YML024W |
Ribosomal protein 51 (rp51) of the small (40s) subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RPS7A |
YOR096W |
Protein component of the small (40S) ribosomal subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RPS22A |
YJL190C |
Protein component of the small (40S) ribosomal subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
BFR1 |
YOR198C |
Component of mRNP complexes associated with polyribosomes |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
FCP1 |
YMR277W |
Carboxy-terminal domain (CTD) phosphatase |
genetic |
1 |
1 |
1 |
Negative Genetic |
PET309 |
YLR067C |
Specific translational activator for the COX1 mRNA |
genetic |
1 |
1 |
1 |
Negative Genetic |
RPL25 |
YOL127W |
Ribosomal 60S subunit protein L25 |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RPL31A |
YDL075W |
Ribosomal 60S subunit protein L31A |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
LRS4 |
YDR439W |
Nucleolar protein that forms a complex with Csm1p |
genetic |
1 |
1 |
1 |
Positive Genetic |
RPS2 |
YGL123W |
Protein component of the small (40S) subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
DOM34 |
YNL001W |
Protein that facilitates ribosomal subunit dissociation |
genetic |
1 |
1 |
1 |
Dosage Rescue |
NOP8 |
YOL144W |
Nucleolar protein required for 60S ribosomal subunit biogenesis |
genetic |
1 |
1 |
1 |
Negative Genetic |
RPS20 |
YHL015W |
Protein component of the small (40S) ribosomal subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RPS0A |
YGR214W |
Ribosomal 40S subunit protein S0A |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
ERG2 |
YMR202W |
C-8 sterol isomerase |
genetic |
1 |
1 |
1 |
Negative Genetic |
MSS4 |
YDR208W |
Phosphatidylinositol-4-phosphate 5-kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
GIS2 |
YNL255C |
Translational activator for mRNAs with internal ribosome entry sites |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
LEU9 |
YOR108W |
Alpha-isopropylmalate synthase II (2-isopropylmalate synthase) |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RPS6A |
YPL090C |
Protein component of the small (40S) ribosomal subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RPL4B |
YDR012W |
Ribosomal 60S subunit protein L4B |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RPS10A |
YOR293W |
Protein component of the small (40S) ribosomal subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
URB1 |
YKL014C |
Protein required for the normal accumulation of 25S and 5.8S rRNAs |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
YCK2 |
YNL154C |
Palmitoylated plasma membrane-bound casein kinase I (CK1) isoform |
physical |
1 |
1 |
1 |
Biochemical Activity |
TPO1 |
YLL028W |
Polyamine transporter of the major facilitator superfamily |
physical |
1 |
1 |
1 |
PCA |
SRO9 |
YCL037C |
Cytoplasmic RNA-binding protein |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
VAM6 |
YDL077C |
Guanine nucleotide exchange factor for the GTPase Gtr1p |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
TOM1 |
YDR457W |
E3 ubiquitin ligase of the hect-domain class |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
UTP14 |
YML093W |
Subunit of U3-containing Small Subunit (SSU) processome complex |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
SSF2 |
YDR312W |
Protein required for ribosomal large subunit maturation |
genetic |
1 |
1 |
1 |
Negative Genetic |
TRZ1 |
YKR079C |
tRNA 3'-end processing endonuclease tRNase Z |
genetic |
1 |
1 |
1 |
Negative Genetic |
TIF4631 |
YGR162W |
Translation initiation factor eIF4G and scaffold protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
YLR287C |
YLR287C |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Positive Genetic |
SAC3 |
YDR159W |
mRNA export factor |
genetic |
1 |
1 |
1 |
Positive Genetic |
SKI8 |
YGL213C |
Ski complex component and WD-repeat protein |
genetic |
1 |
1 |
1 |
Positive Genetic |
UAF30 |
YOR295W |
Subunit of UAF (upstream activation factor) complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
TGS1 |
YPL157W |
Trimethyl guanosine synthase, conserved nucleolar methyl transferase |
genetic |
1 |
1 |
1 |
Positive Genetic |
TOS2 |
YGR221C |
Protein involved in localization of Cdc24p to the site of bud growth |
genetic |
1 |
1 |
1 |
Negative Genetic |
TAF1 |
YGR274C |
TFIID subunit, involved in RNA pol II transcription initiation |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
TEL2 |
YGR099W |
Subunit of the ASTRA complex, involved in chromatin remodeling |
genetic |
1 |
1 |
1 |
Positive Genetic |
SEC26 |
YDR238C |
Essential beta-coat protein of the COPI coatomer |
genetic |
1 |
1 |
1 |
Negative Genetic |
SNU13 |
YEL026W |
RNA binding protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
YJR098C |
YJR098C |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
YLL006W-A |
YLL006W-A |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
YJR154W |
YJR154W |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
SIN4 |
YNL236W |
Subunit of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
RPL26A |
YLR344W |
Ribosomal 60S subunit protein L26A |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
PTK2 |
YJR059W |
Serine/threonine protein kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
EOS1 |
YNL080C |
Protein involved in N-glycosylation |
genetic |
1 |
1 |
1 |
Negative Genetic |
MRPL51 |
YPR100W |
Mitochondrial ribosomal protein of the large subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
RPS27A |
YKL156W |
Protein component of the small (40S) ribosomal subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
INO1 |
YJL153C |
Inositol-3-phosphate synthase |
genetic |
1 |
1 |
1 |
Negative Genetic |
RPI1 |
YIL119C |
Transcription factor, allelic differences between S288C and Sigma1278b |
genetic |
1 |
1 |
1 |
Negative Genetic |
HSP32 |
YPL280W |
Possible chaperone and cysteine protease |
genetic |
1 |
1 |
1 |
Negative Genetic |
EDC1 |
YGL222C |
RNA-binding protein that activates mRNA decapping directly |
genetic |
1 |
1 |
1 |
Positive Genetic |
CDC1 |
YDR182W |
Putative mannose-ethanolamine phosphate phosphodiesterase |
genetic |
1 |
1 |
1 |
Negative Genetic |
RPS15 |
YOL040C |
Protein component of the small (40S) ribosomal subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |