Standard name Systematic name Name description Description
EXO1 YOR033C 5'-3' exonuclease and flap-endonuclease 5'-3' exonuclease and flap-endonuclease; involved in recombination, double-strand break repair, MMS2 error-free branch of the post replication (PRR) pathway and DNA mismatch repair; role in telomere maintenance; member of the Rad2p nuclease family, with conserved N and I nuclease domains; relative distribution to the nucleus increases upon DNA replication stress; EXO1 has a paralog, DIN7, that arose from the whole genome duplication
Visualize the interactome of EXO1
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)
G1(P) 34

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.754 0.728 0.905
Mito 0.146 0.076 NaN
Nucleus 0.093 0.062 NaN
Vac/Vac Memb 0.100 0.187 NaN
Budneck NaN NaN 0.055

GFP localization & abundance

GFP localization GFP abundance
nucleus 672

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
EXO1 9 1 0 1 0

Enzyme information

Catalyzed reactions in Yeast8

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 37 7 34 Synthetic Growth Defect, Negative Genetic, Phenotypic Enhancement, Synthetic Lethality, Negative Genetic, Negative Genetic, Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Enhancement, Dosage Rescue, Phenotypic Suppression, Phenotypic Suppression, Phenotypic Enhancement, Phenotypic Enhancement, Dosage Rescue, Synthetic Lethality, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Lethality, Phenotypic Enhancement, Phenotypic Enhancement, Negative Genetic, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Suppression, Synthetic Growth Defect, Synthetic Rescue, Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Enhancement, Negative Genetic, Synthetic Growth Defect, Phenotypic Enhancement
MRE11 YMR224C Nuclease subunit of the MRX complex with Rad50p and Xrs2p genetic 27 6 25 Dosage Rescue, Dosage Rescue, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Dosage Rescue, Phenotypic Enhancement, Negative Genetic, Dosage Rescue, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect, Dosage Rescue, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Suppression, Dosage Rescue, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Suppression, Synthetic Rescue, Phenotypic Suppression, Phenotypic Suppression
CDC13 YDL220C Single stranded DNA-binding protein found at TG1-3 telomere G-tails genetic 21 6 16 Phenotypic Suppression, Synthetic Growth Defect, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Lethality, Synthetic Rescue, Phenotypic Suppression, Synthetic Rescue, Phenotypic Suppression, Synthetic Rescue, Positive Genetic, Synthetic Rescue, Phenotypic Enhancement, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Phenotypic Suppression, Synthetic Rescue
YKU70 YMR284W Subunit of the telomeric Ku complex (Yku70p-Yku80p) genetic 17 4 15 Synthetic Rescue, Synthetic Rescue, Phenotypic Suppression, Phenotypic Suppression, Synthetic Lethality, Phenotypic Suppression, Synthetic Rescue, Phenotypic Suppression, Phenotypic Suppression, Synthetic Growth Defect, Synthetic Rescue, Phenotypic Suppression, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Phenotypic Suppression, Phenotypic Suppression
RAD27 YKL113C 5' to 3' exonuclease, 5' flap endonuclease genetic 16 6 14 Synthetic Lethality, Synthetic Lethality, Dosage Rescue, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Phenotypic Enhancement, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Suppression, Negative Genetic, Synthetic Lethality, Phenotypic Enhancement, Synthetic Lethality
SAE2 YGL175C Endonuclease required for telomere elongation genetic 16 5 13 Phenotypic Enhancement, Dosage Rescue, Dosage Rescue, Synthetic Lethality, Synthetic Growth Defect, Dosage Rescue, Phenotypic Enhancement, Synthetic Lethality, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Growth Defect, Dosage Rescue, Synthetic Rescue, Synthetic Growth Defect
MLH1 YMR167W Protein required for mismatch repair in mitosis and meiosis physical 14 5 10 Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Protein-peptide, Co-crystal Structure, Two-hybrid, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Two-hybrid
RAD9 YDR217C DNA damage-dependent checkpoint protein genetic 10 4 9 Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Suppression, Phenotypic Suppression, Synthetic Rescue, Phenotypic Enhancement, Phenotypic Suppression, Phenotypic Suppression, Synthetic Rescue, Synthetic Growth Defect
DNA2 YHR164C ATP-dependent 5'-flap endonuclease and DNA helicase genetic 10 5 8 Synthetic Lethality, Dosage Rescue, Dosage Rescue, Phenotypic Enhancement, Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Enhancement
FUN30 YAL019W Snf2p family member with ATP-dependent chromatin remodeling activity genetic 9 4 7 Phenotypic Suppression, Phenotypic Enhancement, Phenotypic Enhancement, Dosage Rescue, Synthetic Growth Defect, Dosage Rescue, Dosage Rescue, Phenotypic Suppression, Synthetic Growth Defect
REV3 YPL167C Catalytic subunit of DNA polymerase zeta genetic 8 5 7 Negative Genetic, Synthetic Rescue, Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Suppression, Synthetic Growth Defect
XRS2 YDR369C FHA domain-containing component of the Mre11 complex genetic 8 4 7 Negative Genetic, Dosage Rescue, Dosage Rescue, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Phenotypic Suppression, Negative Genetic
MEC1 YBR136W Genome integrity checkpoint protein and PI kinase superfamily member genetic 8 4 7 Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Suppression, Synthetic Rescue, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Rescue
MSH2 YOL090W Protein that binds to DNA mismatches physical 8 2 6 Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid
RAD53 YPL153C DNA damage response kinase genetic 7 3 7 Synthetic Rescue, Phenotypic Suppression, Synthetic Rescue, Phenotypic Enhancement, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue
POL30 YBR088C Proliferating cell nuclear antigen (PCNA) genetic 7 3 6 Phenotypic Enhancement, Dosage Rescue, Phenotypic Suppression, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement
POL3 YDL102W Catalytic subunit of DNA polymerase delta genetic 7 3 6 Synthetic Lethality, Synthetic Lethality, Phenotypic Enhancement, Phenotypic Suppression, Synthetic Lethality, Phenotypic Enhancement, Phenotypic Enhancement
PMS1 YNL082W ATP-binding protein required for mismatch repair genetic 7 1 6 Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement
POL32 YJR043C Third subunit of DNA polymerase delta genetic 7 4 4 Phenotypic Enhancement, Synthetic Rescue, Phenotypic Suppression, Phenotypic Enhancement, Synthetic Rescue, Synthetic Growth Defect, Phenotypic Enhancement
RIF1 YBR275C Protein involved in control of DNA replication genetic 7 5 3 Phenotypic Suppression, Synthetic Rescue, Synthetic Growth Defect, Dosage Rescue, Phenotypic Enhancement, Phenotypic Suppression, Phenotypic Enhancement
RAD50 YNL250W Subunit of MRX complex with Mre11p and Xrs2p genetic 6 4 6 Dosage Rescue, Dosage Rescue, Negative Genetic, Dosage Rescue, Phenotypic Enhancement, Phenotypic Suppression
POL2 YNL262W Catalytic subunit of DNA polymerase (II) epsilon genetic 6 2 6 Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Rescue
TEL1 YBL088C Protein kinase primarily involved in telomere length regulation genetic 5 3 4 Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Suppression
PSO2 YMR137C Nuclease required for DNA single- and double-strand break repair genetic 5 2 3 Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Suppression, Phenotypic Enhancement
MSH2 YOL090W Protein that binds to DNA mismatches genetic 4 4 4 Dosage Rescue, Phenotypic Enhancement, Phenotypic Suppression, Synthetic Rescue
MLH1 YMR167W Protein required for mismatch repair in mitosis and meiosis genetic 4 1 4 Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement
RFA1 YAR007C Subunit of heterotrimeric Replication Protein A (RPA) genetic 4 3 3 Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Lethality, Phenotypic Suppression
BMH1 YER177W 14-3-3 protein, major isoform physical 4 2 2 Affinity Capture-Western, Far Western, Affinity Capture-Western, Affinity Capture-Western
RAD5 YLR032W DNA helicase/Ubiquitin ligase genetic 3 3 3 Synthetic Lethality, Phenotypic Enhancement, Synthetic Growth Defect
RAD1 YPL022W Single-stranded DNA endonuclease (with Rad10p) genetic 3 2 3 Phenotypic Enhancement, Phenotypic Suppression, Phenotypic Enhancement
RAD51 YER095W Strand exchange protein genetic 3 2 3 Phenotypic Suppression, Phenotypic Enhancement, Phenotypic Suppression
RAD52 YML032C Protein involved in homologous recombination genetic 3 2 3 Synthetic Lethality, Phenotypic Suppression, Synthetic Lethality
POL1 YNL102W Catalytic subunit of the DNA polymerase I alpha-primase complex genetic 3 2 3 Phenotypic Enhancement, Synthetic Rescue, Phenotypic Enhancement
BRE1 YDL074C E3 ubiquitin ligase genetic 3 3 2 Synthetic Rescue, Phenotypic Suppression, Synthetic Growth Defect
APN1 YKL114C Major apurinic/apyrimidinic endonuclease genetic 3 3 2 Phenotypic Suppression, Phenotypic Enhancement, Synthetic Growth Defect
PTP3 YER075C Phosphotyrosine-specific protein phosphatase genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
PDA1 YER178W E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
MMS22 YLR320W Subunit of E3 ubiquitin ligase complex involved in replication repair genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
JNM1 YMR294W Component of the yeast dynactin complex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
HUB1 YNR032C-A Ubiquitin-like protein modifier genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
RIF2 YLR453C Protein that binds to the Rap1p C-terminus genetic 3 1 2 Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement
CHS6 YJL099W Member of the ChAPs (Chs5p-Arf1p-binding proteins) family genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
CDC5 YMR001C Polo-like kinase required for mitotic exit physical 3 3 1 Affinity Capture-Western, Reconstituted Complex, Two-hybrid
MLH3 YPL164C Protein involved in DNA mismatch repair and meiotic recombination physical 3 2 1 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western
BMH1 YER177W 14-3-3 protein, major isoform genetic 2 2 2 Synthetic Rescue, Phenotypic Suppression
EST1 YLR233C TLC1 RNA-associated factor involved in telomere length regulation genetic 2 2 2 Synthetic Rescue, Synthetic Growth Defect
ADD66 YKL206C Protein involved in 20S proteasome assembly genetic 2 2 2 Negative Genetic, Positive Genetic
TOP1 YOL006C Topoisomerase I genetic 2 2 2 Synthetic Lethality, Synthetic Growth Defect
YKU80 YMR106C Subunit of telomeric Ku complex (Yku70p-Yku80p) genetic 2 2 2 Synthetic Rescue, Phenotypic Enhancement
SIN3 YOL004W Component of both the Rpd3S and Rpd3L histone deacetylase complexes genetic 2 2 2 Negative Genetic, Phenotypic Suppression
TRM2 YKR056W tRNA methyltransferase genetic 2 2 2 Phenotypic Enhancement, Synthetic Growth Defect
RAP1 YNL216W Essential DNA-binding transcription regulator that binds many loci genetic 2 2 2 Synthetic Growth Defect, Phenotypic Suppression
STN1 YDR082W Telomere end-binding and capping protein genetic 2 2 2 Phenotypic Suppression, Positive Genetic
RNH201 YNL072W Ribonuclease H2 catalytic subunit genetic 2 2 2 Phenotypic Suppression, Synthetic Rescue
CHK1 YBR274W Serine/threonine kinase and DNA damage checkpoint effector genetic 2 1 2 Phenotypic Enhancement, Phenotypic Enhancement
AFG3 YER017C Mitochondrial inner membrane m-AAA protease component genetic 2 1 2 Negative Genetic, Negative Genetic
RNR1 YER070W Major isoform of large subunit of ribonucleotide-diphosphate reductase genetic 2 1 2 Phenotypic Enhancement, Phenotypic Enhancement
RMI1 YPL024W Subunit of the RecQ (Sgs1p) - Topo III (Top3p) complex genetic 2 1 2 Negative Genetic, Negative Genetic
YPT31 YER031C Rab family GTPase genetic 2 1 2 Negative Genetic, Negative Genetic
RRF1 YHR038W Mitochondrial ribosome recycling factor genetic 2 1 2 Negative Genetic, Negative Genetic
TAF9 YMR236W Subunit (17 kDa) of TFIID and SAGA complexes genetic 2 1 2 Negative Genetic, Negative Genetic
SLH1 YGR271W Subunit of ribosome-associated quality control trigger complex (RQT) genetic 2 1 2 Negative Genetic, Negative Genetic
HOL1 YNR055C Putative transporter in the major facilitator superfamily genetic 2 1 2 Negative Genetic, Negative Genetic
APJ1 YNL077W Hsp40 chaperone with a role in SUMO-mediated protein degradation genetic 2 1 2 Negative Genetic, Negative Genetic
ATP23 YNR020C Putative metalloprotease of the mitochondrial inner membrane genetic 2 1 2 Negative Genetic, Negative Genetic
CHD1 YER164W Chromatin remodeler that regulates various aspects of transcription physical 2 2 1 Affinity Capture-MS, Affinity Capture-Western
BMH2 YDR099W 14-3-3 protein, minor isoform physical 2 2 1 Affinity Capture-Western, Far Western
DDC1 YPL194W DNA damage checkpoint protein genetic 2 2 1 Synthetic Rescue, Phenotypic Suppression
CLB2 YPR119W B-type cyclin involved in cell cycle progression genetic 2 2 1 Synthetic Growth Defect, Phenotypic Suppression
IRC20 YLR247C E3 ubiquitin ligase and putative helicase genetic 2 2 1 Phenotypic Enhancement, Phenotypic Suppression
NPL3 YDR432W RNA-binding protein genetic 2 2 1 Dosage Rescue, Phenotypic Suppression
NEJ1 YLR265C DNA end-binding protein required for nonhomologous end joining (NHEJ) genetic 2 2 1 Phenotypic Enhancement, Phenotypic Suppression
RAD24 YER173W Checkpoint protein genetic 2 2 1 Synthetic Rescue, Phenotypic Suppression
FUN30 YAL019W Snf2p family member with ATP-dependent chromatin remodeling activity physical 2 1 1 Affinity Capture-Western, Affinity Capture-Western
GLC7 YER133W Type 1 S/T protein phosphatase (PP1) catalytic subunit genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
RSA3 YLR221C Protein with a likely role in ribosomal maturation genetic 2 1 1 Negative Genetic, Negative Genetic
YMD8 YML038C Putative nucleotide sugar transporter genetic 2 1 1 Negative Genetic, Negative Genetic
PUB1 YNL016W Poly (A)+ RNA-binding protein genetic 2 1 1 Negative Genetic, Negative Genetic
PET8 YNL003C S-adenosylmethionine transporter of the mitochondrial inner membrane genetic 2 1 1 Negative Genetic, Negative Genetic
SFP1 YLR403W Regulates transcription of ribosomal protein and biogenesis genes regulation 1 1 1 DNA to cDNA expression microarray evidence
NPL3 YDR432W RNA-binding protein regulation 1 1 1 northern blot evidence
RRP6 YOR001W Nuclear exosome exonuclease component regulation 1 1 1 quantitative reverse transcription polymerase chain reaction evidence
CDC73 YLR418C Component of the Paf1p complex genetic 1 1 1 Phenotypic Enhancement
ASF1 YJL115W Nucleosome assembly factor genetic 1 1 1 Negative Genetic
BMH2 YDR099W 14-3-3 protein, minor isoform genetic 1 1 1 Phenotypic Suppression
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit genetic 1 1 1 Dosage Lethality
DCP2 YNL118C Catalytic subunit of Dcp1p-Dcp2p decapping enzyme complex genetic 1 1 1 Negative Genetic
ARP8 YOR141C Nuclear actin-related protein involved in chromatin remodeling genetic 1 1 1 Negative Genetic
DOA4 YDR069C Ubiquitin hydrolase genetic 1 1 1 Negative Genetic
BOI1 YBL085W Protein involved in polar growth, functionally redundant with Boi2p physical 1 1 1 Affinity Capture-MS
ATP3 YBR039W Gamma subunit of the F1 sector of mitochondrial F1F0 ATP synthase genetic 1 1 1 Negative Genetic
DUN1 YDL101C Cell-cycle checkpoint S/T protein kinase genetic 1 1 1 Phenotypic Suppression
DNL4 YOR005C DNA ligase required for nonhomologous end-joining (NHEJ) genetic 1 1 1 Negative Genetic
DPB11 YJL090C DNA replication initiation protein genetic 1 1 1 Synthetic Rescue
BEM4 YPL161C Protein involved in establishment of cell polarity and bud emergence genetic 1 1 1 Negative Genetic
EPT1 YHR123W sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferase genetic 1 1 1 Negative Genetic
ELG1 YOR144C Subunit of an alternative replication factor C complex genetic 1 1 1 Phenotypic Enhancement
BIR1 YJR089W Subunit of chromosomal passenger complex (CPC) genetic 1 1 1 Negative Genetic
BRF1 YGR246C TFIIIB B-related factor physical 1 1 1 Affinity Capture-MS
CET1 YPL228W RNA 5'-triphosphatase involved in mRNA 5' capping genetic 1 1 1 Negative Genetic
DBP5 YOR046C Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family genetic 1 1 1 Synthetic Lethality
HSP82 YPL240C Hsp90 chaperone physical 1 1 1 Affinity Capture-MS
MEC3 YLR288C DNA damage and meiotic pachytene checkpoint protein physical 1 1 1 Two-hybrid
SRS2 YJL092W DNA helicase and DNA-dependent ATPase physical 1 1 1 Affinity Capture-Western
SRS2 YJL092W DNA helicase and DNA-dependent ATPase genetic 1 1 1 Phenotypic Suppression
SIZ1 YDR409W SUMO E3 ligase physical 1 1 1 Biochemical Activity
NFI1 YOR156C SUMO E3 ligase physical 1 1 1 Biochemical Activity
ISW1 YBR245C ATPase subunit of imitation-switch (ISWI) class chromatin remodelers physical 1 1 1 Affinity Capture-RNA
RRP6 YOR001W Nuclear exosome exonuclease component physical 1 1 1 Affinity Capture-MS
RRP6 YOR001W Nuclear exosome exonuclease component genetic 1 1 1 Negative Genetic
MOG1 YJR074W Conserved nuclear protein that interacts with GTP-Gsp1p physical 1 1 1 Affinity Capture-MS
SEN1 YLR430W ATP-dependent 5' to 3' RNA/DNA and DNA helicase physical 1 1 1 Affinity Capture-MS
RPC34 YNR003C RNA polymerase III subunit C34 physical 1 1 1 Affinity Capture-MS
THI20 YOL055C Trifunctional enzyme of thiamine biosynthesis, degradation and salvage physical 1 1 1 Affinity Capture-MS
GRH1 YDR517W Acetylated cis-Golgi protein, homolog of human GRASP65 physical 1 1 1 Affinity Capture-MS
RVS161 YCR009C Amphiphysin-like lipid raft protein physical 1 1 1 Affinity Capture-MS
MSH6 YDR097C Protein required for mismatch repair in mitosis and meiosis physical 1 1 1 Affinity Capture-MS
SEC6 YIL068C Essential 88kDa subunit of the exocyst complex physical 1 1 1 Affinity Capture-MS
PWP1 YLR196W Protein with WD-40 repeats involved in rRNA processing physical 1 1 1 Affinity Capture-MS
MSH3 YCR092C Mismatch repair protein genetic 1 1 1 Phenotypic Enhancement
MSH4 YFL003C Protein involved in meiotic recombination genetic 1 1 1 Phenotypic Enhancement
MMS1 YPR164W Subunit of E3 ubiquitin ligase complex involved in replication repair genetic 1 1 1 Negative Genetic
HTZ1 YOL012C Histone variant H2AZ genetic 1 1 1 Negative Genetic
TOP3 YLR234W DNA Topoisomerase III genetic 1 1 1 Negative Genetic
SWI5 YDR146C Transcription factor that recruits Mediator and Swi/Snf complexes genetic 1 1 1 Negative Genetic
PGD1 YGL025C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
HO YDL227C Site-specific endonuclease genetic 1 1 1 Negative Genetic
UBP15 YMR304W Ubiquitin-specific protease involved in protein deubiquitination genetic 1 1 1 Negative Genetic
RAD17 YOR368W Checkpoint protein genetic 1 1 1 Negative Genetic
TLG2 YOL018C Syntaxin-like t-SNARE genetic 1 1 1 Synthetic Growth Defect
TEN1 YLR010C Protein that regulates telomeric length genetic 1 1 1 Synthetic Rescue
ORC2 YBR060C Subunit of the origin recognition complex (ORC) genetic 1 1 1 Negative Genetic
SSY1 YDR160W Component of the SPS plasma membrane amino acid sensor system genetic 1 1 1 Negative Genetic
TOR2 YKL203C PIK-related protein kinase and rapamycin target genetic 1 1 1 Positive Genetic
HUL5 YGL141W Multiubiquitin chain assembly factor (E4) genetic 1 1 1 Negative Genetic
PKP2 YGL059W Mitochondrial protein kinase genetic 1 1 1 Negative Genetic
RPL31B YLR406C Ribosomal 60S subunit protein L31B genetic 1 1 1 Negative Genetic
TDP1 YBR223C Tyrosyl-DNA phosphodiesterase I genetic 1 1 1 Phenotypic Enhancement
PIF1 YML061C DNA helicase, potent G-quadruplex DNA binder/unwinder genetic 1 1 1 Synthetic Lethality
REV1 YOR346W Deoxycytidyl transferase genetic 1 1 1 Phenotypic Enhancement
REV7 YIL139C Accessory subunit of DNA polymerase zeta genetic 1 1 1 Phenotypic Enhancement
RAD30 YDR419W DNA polymerase eta genetic 1 1 1 Phenotypic Enhancement
HMT1 YBR034C Nuclear SAM-dependent mono- and asymmetric methyltransferase genetic 1 1 1 Negative Genetic
RAD18 YCR066W E3 ubiquitin ligase genetic 1 1 1 Phenotypic Suppression
NTG1 YAL015C DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase genetic 1 1 1 Phenotypic Suppression
NTG2 YOL043C DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase genetic 1 1 1 Phenotypic Suppression
SNF2 YOR290C Catalytic subunit of the SWI/SNF chromatin remodeling complex genetic 1 1 1 Phenotypic Enhancement
THP2 YHR167W Subunit of the THO and TREX complexes genetic 1 1 1 Phenotypic Suppression
ISW2 YOR304W ATP-dependent DNA translocase involved in chromatin remodeling genetic 1 1 1 Synthetic Growth Defect
NHP10 YDL002C Non-essential INO80 chromatin remodeling complex subunit genetic 1 1 1 Synthetic Growth Defect
RNH202 YDR279W Ribonuclease H2 subunit genetic 1 1 1 Phenotypic Enhancement
SWR1 YDR334W Swi2/Snf2-related ATPase genetic 1 1 1 Phenotypic Enhancement
SOM1 YEL059C-A Subunit of the mitochondrial inner membrane peptidase (IMP) genetic 1 1 1 Positive Genetic
PET117 YER058W Assembly factor that couples heme a synthesis to complex IV assembly genetic 1 1 1 Positive Genetic
ROF1 YHR177W Putative transcription factor containing a WOPR domain genetic 1 1 1 Positive Genetic
PET111 YMR257C Mitochondrial translational activator specific for the COX2 mRNA genetic 1 1 1 Positive Genetic
THR4 YCR053W Threonine synthase genetic 1 1 1 Positive Genetic
RRP43 YCR035C Exosome non-catalytic core component genetic 1 1 1 Negative Genetic
RSA4 YCR072C Ribosomal large subunit (60S) assembly factor genetic 1 1 1 Negative Genetic
USE1 YGL098W Essential SNARE protein localized to the ER genetic 1 1 1 Negative Genetic
RPC31 YNL151C RNA polymerase III subunit C31 genetic 1 1 1 Negative Genetic
RFC1 YOR217W Subunit of heteropentameric Replication factor C (RF-C) genetic 1 1 1 Negative Genetic
TEF2 YBR118W Translational elongation factor EF-1 alpha genetic 1 1 1 Negative Genetic
MRPL36 YBR122C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
MRPS9 YBR146W Mitochondrial ribosomal protein of the small subunit genetic 1 1 1 Negative Genetic
MRPS5 YBR251W Mitochondrial ribosomal protein of the small subunit genetic 1 1 1 Negative Genetic
MHR1 YDR296W Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
MRPL35 YDR322W Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
PAL1 YDR348C Protein of unknown function thought to be involved in endocytosis genetic 1 1 1 Negative Genetic
MRPL28 YDR462W Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
UGO1 YDR470C Outer membrane component of the mitochondrial fusion machinery genetic 1 1 1 Negative Genetic
YDR514C YDR514C Protein of unknown function that localizes to mitochondria genetic 1 1 1 Negative Genetic
YDR524C-B YDR524C-B Putative protein of unknown function genetic 1 1 1 Negative Genetic
PAU2 YEL049W Member of the seripauperin multigene family genetic 1 1 1 Negative Genetic
RPL2A YFR031C-A Ribosomal 60S subunit protein L2A genetic 1 1 1 Negative Genetic
MRF1 YGL143C Mitochondrial translation release factor genetic 1 1 1 Negative Genetic
MEP1 YGR121C Ammonium permease genetic 1 1 1 Negative Genetic
MTG2 YHR168W Putative GTPase genetic 1 1 1 Negative Genetic
IRC8 YJL051W Bud tip localized protein of unknown function genetic 1 1 1 Negative Genetic
MRPL8 YJL063C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
MRPL49 YJL096W Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
TOR1 YJR066W PIK-related protein kinase and rapamycin target genetic 1 1 1 Negative Genetic
SOR1 YJR159W Sorbitol dehydrogenase genetic 1 1 1 Negative Genetic
MRPL20 YKR085C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
LMO1 YLL007C Homolog of mammalian ELMO (Engulfment and celL MOtility) genetic 1 1 1 Negative Genetic
STM1 YLR150W Protein required for optimal translation under nutrient stress genetic 1 1 1 Negative Genetic
MUS81 YDR386W Subunit of structure-specific Mms4p-Mus81p endonuclease genetic 1 1 1 Synthetic Growth Defect
SOV1 YMR066W Mitochondrial protein of unknown function genetic 1 1 1 Negative Genetic
PPA2 YMR267W Mitochondrial inorganic pyrophosphatase genetic 1 1 1 Negative Genetic
MRPL22 YNL177C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
MRPL19 YNL185C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
VMA21 YGR105W Integral membrane protein required for V-ATPase function genetic 1 1 1 Negative Genetic
YHR022C YHR022C Putative protein of unknown function genetic 1 1 1 Negative Genetic
MRT4 YKL009W Protein involved in mRNA turnover and ribosome assembly genetic 1 1 1 Negative Genetic
FMP46 YKR049C Putative redox protein containing a thioredoxin fold genetic 1 1 1 Negative Genetic
YLR053C YLR053C Putative protein of unknown function genetic 1 1 1 Negative Genetic
MAC1 YMR021C Copper-sensing transcription factor genetic 1 1 1 Negative Genetic
NIP100 YPL174C Large subunit of the dynactin complex genetic 1 1 1 Negative Genetic
VTS1 YOR359W Flap-structured DNA-binding and RNA-binding protein genetic 1 1 1 Negative Genetic
MRPS16 YPL013C Mitochondrial ribosomal protein of the small subunit genetic 1 1 1 Negative Genetic
RNH1 YMR234W Ribonuclease H1 genetic 1 1 1 Phenotypic Suppression
MRPL51 YPR100W Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
GLN3 YER040W Transcriptional activator in nitrogen catabolite repression system genetic 1 1 1 Phenotypic Enhancement
URA7 YBL039C Major CTP synthase isozyme (see also URA8) genetic 1 1 1 Phenotypic Enhancement
SNF5 YBR289W Subunit of the SWI/SNF chromatin remodeling complex genetic 1 1 1 Phenotypic Enhancement
SDS22 YKL193C Regulatory subunit of the type 1 protein phosphatase (PP1) Glc7p genetic 1 1 1 Positive Genetic
STE6 YKL209C Plasma membrane ATP-binding cassette (ABC) transporter genetic 1 1 1 Positive Genetic
LCD1 YDR499W Essential protein required for the DNA integrity checkpoint pathways genetic 1 1 1 Phenotypic Enhancement
RAD59 YDL059C Protein involved DNA double-strand break repair genetic 1 1 1 Synthetic Growth Defect
RSC2 YLR357W Component of the RSC chromatin remodeling complex genetic 1 1 1 Phenotypic Enhancement
YEN1 YER041W Holliday junction resolvase genetic 1 1 1 Phenotypic Suppression
RAD6 YGL058W Ubiquitin-conjugating enzyme (E2) genetic 1 1 1 Synthetic Rescue
HTB1 YDR224C Histone H2B genetic 1 1 1 Synthetic Rescue
RPH1 YER169W JmjC domain-containing histone demethylase genetic 1 1 1 Phenotypic Enhancement
NMD2 YHR077C Protein involved in the nonsense-mediated mRNA decay (NMD) pathway genetic 1 1 1 Synthetic Rescue
ILV1 YER086W Threonine deaminase, catalyzes first step in isoleucine biosynthesis genetic 1 1 1 Negative Genetic
SMC6 YLR383W Subunit of the SMC5-SMC6 complex genetic 1 1 1 Synthetic Rescue
HRQ1 YDR291W 3'-5' DNA helicase of the conserved RecQ family genetic 1 1 1 Negative Genetic
HTA1 YDR225W Histone H2A genetic 1 1 1 Synthetic Growth Defect
RNR2 YJL026W Ribonucleotide-diphosphate reductase (RNR), small subunit genetic 1 1 1 Dosage Rescue
RNR3 YIL066C Minor isoform of large subunit of ribonucleotide-diphosphate reductase genetic 1 1 1 Dosage Rescue
RNR4 YGR180C Ribonucleotide-diphosphate reductase (RNR) small subunit genetic 1 1 1 Dosage Rescue
EMP46 YLR080W Integral membrane component of ER-derived COPII-coated vesicles genetic 1 1 1 Positive Genetic
CSG2 YBR036C Endoplasmic reticulum membrane protein genetic 1 1 1 Negative Genetic
ESC2 YDR363W Sumo-like domain protein genetic 1 1 1 Phenotypic Suppression
APN2 YBL019W Class II abasic (AP) endonuclease involved in repair of DNA damage genetic 1 1 1 Synthetic Rescue
COQ9 YLR201C Protein required for ubiquinone biosynthesis and respiratory growth genetic 1 1 1 Positive Genetic
CPR5 YDR304C Peptidyl-prolyl cis-trans isomerase (cyclophilin) of the ER genetic 1 1 1 Negative Genetic
CBS1 YDL069C Mitochondrial translational activator of the COB mRNA genetic 1 1 1 Positive Genetic
COQ6 YGR255C Flavin-dependent monooxygenase involved in ubiquinone biosynthesis genetic 1 1 1 Positive Genetic
AIM23 YJL131C Mitochondrial translation initiation factor 3 (IF3, mIF3) genetic 1 1 1 Positive Genetic
EMA35 YCR100C Protein involved in protein sorting genetic 1 1 1 Negative Genetic
EOS1 YNL080C Protein involved in N-glycosylation genetic 1 1 1 Negative Genetic
EST2 YLR318W Reverse transcriptase subunit of the telomerase holoenzyme genetic 1 1 1 Synthetic Rescue
CWC27 YPL064C Component of a complex containing Cef1p genetic 1 1 1 Negative Genetic
COX9 YDL067C Subunit VIIa of cytochrome c oxidase (Complex IV) genetic 1 1 1 Positive Genetic
DPC25 YPL107W Putative mitochondrial protein of unknown function genetic 1 1 1 Negative Genetic
AIM24 YJR080C Protein with a role in determining mitochondrial architecture genetic 1 1 1 Negative Genetic