Standard name Systematic name Name description Description
LCD1 YDR499W Essential protein required for the DNA integrity checkpoint pathways Essential protein required for the DNA integrity checkpoint pathways; interacts physically with Mec1p and contributes to its activation; putative homolog of S. pombe Rad26 and human ATRIP; forms nuclear foci upon DNA replication stress
Visualize the interactome of LCD1
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)
G1 252

CYCLoPs localization & abundance

WT1 WT2 WT3
Mito 0.372 0.426 0.067
Nucleus 0.636 0.463 0.631
Vac/Vac Memb 0.124 0.128 NaN
Cytoplasm NaN 0.176 0.236
SpindlePole NaN NaN 0.056

GFP localization & abundance

GFP localization GFP abundance
cytoplasm, nucleus 606

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
LCD1 1 0 0 1 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
MEC1 YBR136W Genome integrity checkpoint protein and PI kinase superfamily member physical 26 7 17 Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Two-hybrid, Co-localization, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Biochemical Activity, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-MS, Reconstituted Complex, Affinity Capture-MS, Biochemical Activity, Two-hybrid, Affinity Capture-Western, Co-crystal Structure, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS
RFA1 YAR007C Subunit of heterotrimeric Replication Protein A (RPA) physical 8 6 5 Co-localization, Affinity Capture-Western, Affinity Capture-MS, Reconstituted Complex, Protein-peptide, Co-crystal Structure, Affinity Capture-Western, Affinity Capture-MS
SML1 YML058W Ribonucleotide reductase inhibitor genetic 6 3 5 Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Lethality, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue
TEL1 YBL088C Protein kinase primarily involved in telomere length regulation genetic 3 3 3 Dosage Rescue, Phenotypic Suppression, Synthetic Growth Defect
CRM1 YGR218W Nuclear export factor, exportin physical 3 3 2 Reconstituted Complex, Two-hybrid, Affinity Capture-MS
ZIP1 YDR285W Transverse filament protein of the synaptonemal complex genetic 3 2 2 Phenotypic Suppression, Synthetic Growth Defect, Phenotypic Suppression
DMC1 YER179W Meiosis-specific recombinase required for double-strand break repair genetic 3 3 1 Phenotypic Suppression, Synthetic Growth Defect, Synthetic Lethality
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit genetic 2 2 2 Synthetic Rescue, Phenotypic Suppression
FKH1 YIL131C Forkhead family transcription factor regulation 2 1 2 chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation-chip evidence
DNA2 YHR164C ATP-dependent 5'-flap endonuclease and DNA helicase physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 2 1 2 Affinity Capture-RNA, Affinity Capture-RNA
MSH6 YDR097C Protein required for mismatch repair in mitosis and meiosis physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
DPB11 YJL090C DNA replication initiation protein physical 2 1 2 Reconstituted Complex, Reconstituted Complex
LCD1 YDR499W Essential protein required for the DNA integrity checkpoint pathways physical 2 2 1 Co-crystal Structure, Affinity Capture-Western
RAD54 YGL163C DNA-dependent ATPase that stimulates strand exchange genetic 2 2 1 Phenotypic Suppression, Synthetic Lethality
INO80 YGL150C Nucleosome spacing factor physical 2 2 1 Affinity Capture-MS, Affinity Capture-Western
HOP2 YGL033W Meiosis-specific protein that localizes to chromosomes genetic 2 2 1 Synthetic Lethality, Phenotypic Suppression
RPD3 YNL330C Histone deacetylase, component of both the Rpd3S and Rpd3L complexes genetic 2 1 1 Dosage Lethality, Dosage Lethality
BUL2 YML111W Alpha-arrestin, component of the Rsp5p E3-ubiquitin ligase complex physical 2 1 1 Affinity Capture-Western, Affinity Capture-Western
RGR1 YLR071C Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
TFC7 YOR110W RNA pol III transcription initiation factor complex (TFIIIC) subunit regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MEC1 YBR136W Genome integrity checkpoint protein and PI kinase superfamily member regulation 1 1 1 qualitative western immunoblotting evidence
CDC73 YLR418C Component of the Paf1p complex genetic 1 1 1 Synthetic Lethality
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
ASF1 YJL115W Nucleosome assembly factor genetic 1 1 1 Dosage Growth Defect
HHF1 YBR009C Histone H4 physical 1 1 1 Affinity Capture-MS
RNQ1 YCL028W [PIN(+)] prion physical 1 1 1 Affinity Capture-MS
MEC1 YBR136W Genome integrity checkpoint protein and PI kinase superfamily member genetic 1 1 1 Phenotypic Suppression
RFA1 YAR007C Subunit of heterotrimeric Replication Protein A (RPA) genetic 1 1 1 Synthetic Growth Defect
YJR096W YJR096W Xylose and arabinose reductase physical 1 1 1 Affinity Capture-MS
RFA2 YNL312W Subunit of heterotrimeric Replication Protein A (RPA) physical 1 1 1 Affinity Capture-MS
SNF2 YOR290C Catalytic subunit of the SWI/SNF chromatin remodeling complex physical 1 1 1 Affinity Capture-MS
RTF1 YGL244W Subunit of RNAPII-associated chromatin remodeling Paf1 complex physical 1 1 1 Affinity Capture-Western
MPT5 YGL178W mRNA-binding protein of the PUF family physical 1 1 1 Affinity Capture-RNA
RSP5 YER125W NEDD4 family E3 ubiquitin ligase physical 1 1 1 Affinity Capture-Western
MPS3 YJL019W Nuclear envelope protein physical 1 1 1 Affinity Capture-MS
TRA1 YHR099W Subunit of SAGA and NuA4 histone acetyltransferase complexes physical 1 1 1 Reconstituted Complex
RET1 YOR207C Second-largest subunit of RNA polymerase III physical 1 1 1 Affinity Capture-MS
TFC6 YDR362C Subunit of RNA polymerase III transcription initiation factor complex physical 1 1 1 Affinity Capture-MS
MMS1 YPR164W Subunit of E3 ubiquitin ligase complex involved in replication repair genetic 1 1 1 Dosage Growth Defect
RAD27 YKL113C 5' to 3' exonuclease, 5' flap endonuclease genetic 1 1 1 Dosage Lethality
RTT101 YJL047C Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex genetic 1 1 1 Dosage Growth Defect
RTT109 YLL002W Histone acetyltransferase genetic 1 1 1 Dosage Growth Defect
TOF1 YNL273W Subunit of a replication-pausing checkpoint complex genetic 1 1 1 Dosage Growth Defect
PRI1 YIR008C Subunit of DNA primase genetic 1 1 1 Synthetic Lethality
SAE2 YGL175C Endonuclease required for telomere elongation genetic 1 1 1 Phenotypic Suppression
PIN4 YBL051C Protein involved in G2/M phase progression and response to DNA damage genetic 1 1 1 Phenotypic Suppression
SLT2 YHR030C Serine/threonine MAP kinase genetic 1 1 1 Dosage Growth Defect
MMS4 YBR098W Subunit of structure-specific Mms4p-Mus81p endonuclease genetic 1 1 1 Phenotypic Suppression
SMC6 YLR383W Subunit of the SMC5-SMC6 complex genetic 1 1 1 Dosage Rescue
HTZ1 YOL012C Histone variant H2AZ genetic 1 1 1 Phenotypic Suppression
HFI1 YPL254W Adaptor protein required for structural integrity of the SAGA complex physical 1 1 1 Affinity Capture-MS
HEK2 YBL032W RNA binding protein involved in asymmetric localization of ASH1 mRNA physical 1 1 1 Affinity Capture-RNA
CDC13 YDL220C Single stranded DNA-binding protein found at TG1-3 telomere G-tails genetic 1 1 1 Phenotypic Suppression
ADH2 YMR303C Glucose-repressible alcohol dehydrogenase II physical 1 1 1 Affinity Capture-MS
CDC5 YMR001C Polo-like kinase required for mitotic exit genetic 1 1 1 Phenotypic Suppression
ILV5 YLR355C Acetohydroxyacid reductoisomerase and mtDNA binding protein physical 1 1 1 Affinity Capture-MS
DUN1 YDL101C Cell-cycle checkpoint S/T protein kinase genetic 1 1 1 Dosage Lethality
HEM15 YOR176W Ferrochelatase physical 1 1 1 Affinity Capture-MS
HOG1 YLR113W Mitogen-activated protein kinase involved in osmoregulation genetic 1 1 1 Dosage Growth Defect
CTF4 YPR135W Chromatin-associated protein genetic 1 1 1 Dosage Growth Defect
DPB11 YJL090C DNA replication initiation protein genetic 1 1 1 Dosage Rescue
ADH5 YBR145W Alcohol dehydrogenase isoenzyme V physical 1 1 1 Affinity Capture-MS
CSM3 YMR048W Replication fork associated factor genetic 1 1 1 Dosage Growth Defect
ARP5 YNL059C Nuclear actin-related protein involved in chromatin remodeling physical 1 1 1 Affinity Capture-Western
EXO1 YOR033C 5'-3' exonuclease and flap-endonuclease genetic 1 1 1 Phenotypic Enhancement
EMC5 YIL027C Member of conserved ER transmembrane complex physical 1 1 1 PCA