| RRM3 |
YHR031C |
DNA helicase involved in rDNA replication and Ty1 transposition |
genetic |
9 |
3 |
7 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Lethality, Negative Genetic, Negative Genetic |
| CLA4 |
YNL298W |
Cdc42p-activated signal transducing kinase |
genetic |
8 |
4 |
8 |
Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Dosage Growth Defect, Negative Genetic |
| MMS22 |
YLR320W |
Subunit of E3 ubiquitin ligase complex involved in replication repair |
physical |
8 |
3 |
5 |
Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Two-hybrid, Affinity Capture-MS, Affinity Capture-Western |
| TSA1 |
YML028W |
Thioredoxin peroxidase |
genetic |
6 |
2 |
4 |
Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic |
| CLB2 |
YPR119W |
B-type cyclin involved in cell cycle progression |
genetic |
6 |
1 |
4 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| MRC1 |
YCL061C |
S-phase checkpoint protein required for DNA replication |
genetic |
6 |
4 |
3 |
Positive Genetic, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Phenotypic Suppression, Dosage Growth Defect |
| RTT107 |
YHR154W |
BRCA1 C-terminal domain protein needed for recovery from DNA damage |
physical |
5 |
3 |
4 |
Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Two-hybrid |
| RAD27 |
YKL113C |
5' to 3' exonuclease, 5' flap endonuclease |
genetic |
5 |
3 |
4 |
Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Rescue |
| HUR1 |
YGL168W |
Protein with a role in DNA repair |
genetic |
5 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| HST3 |
YOR025W |
Sirtuin, histone H3 deacetylase |
genetic |
4 |
2 |
4 |
Synthetic Rescue, Phenotypic Suppression, Phenotypic Suppression, Synthetic Rescue |
| RTT107 |
YHR154W |
BRCA1 C-terminal domain protein needed for recovery from DNA damage |
genetic |
4 |
2 |
4 |
Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic |
| SLX4 |
YLR135W |
Endonuclease involved in processing DNA |
genetic |
4 |
2 |
4 |
Negative Genetic, Negative Genetic, Synthetic Rescue, Negative Genetic |
| PPH3 |
YDR075W |
Catalytic subunit of protein phosphatase PP4 complex |
genetic |
4 |
1 |
4 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| HRT1 |
YOL133W |
RING-H2 domain core subunit of multiple ubiquitin ligase complexes |
physical |
4 |
3 |
3 |
Affinity Capture-MS, Two-hybrid, Affinity Capture-Western, Two-hybrid |
| DIA2 |
YOR080W |
Origin-binding F-box protein |
genetic |
4 |
2 |
3 |
Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect |
| MMS1 |
YPR164W |
Subunit of E3 ubiquitin ligase complex involved in replication repair |
physical |
4 |
2 |
3 |
Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS |
| PMR1 |
YGL167C |
High affinity Ca2+/Mn2+ P-type ATPase |
genetic |
4 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| RAD52 |
YML032C |
Protein involved in homologous recombination |
genetic |
3 |
3 |
3 |
Synthetic Growth Defect, Phenotypic Suppression, Positive Genetic |
| RAD9 |
YDR217C |
DNA damage-dependent checkpoint protein |
genetic |
3 |
3 |
3 |
Synthetic Rescue, Phenotypic Suppression, Phenotypic Enhancement |
| GET1 |
YGL020C |
Subunit of the GET complex |
genetic |
3 |
2 |
3 |
Negative Genetic, Synthetic Growth Defect, Negative Genetic |
| HHT2 |
YNL031C |
Histone H3 |
genetic |
3 |
2 |
3 |
Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Suppression |
| XRS2 |
YDR369C |
FHA domain-containing component of the Mre11 complex |
genetic |
3 |
2 |
3 |
Negative Genetic, Synthetic Growth Defect, Negative Genetic |
| SGS1 |
YMR190C |
RecQ family nucleolar DNA helicase |
genetic |
3 |
2 |
3 |
Synthetic Growth Defect, Negative Genetic, Negative Genetic |
| HST4 |
YDR191W |
NAD(+)-dependent protein deacetylase |
genetic |
3 |
2 |
3 |
Synthetic Rescue, Phenotypic Suppression, Synthetic Rescue |
| DST1 |
YGL043W |
General transcription elongation factor TFIIS |
genetic |
3 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic |
| BUB1 |
YGR188C |
Protein kinase involved in the cell cycle checkpoint into anaphase |
genetic |
3 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic |
| POL30 |
YBR088C |
Proliferating cell nuclear antigen (PCNA) |
genetic |
3 |
3 |
2 |
Negative Genetic, Synthetic Growth Defect, Dosage Rescue |
| SPT16 |
YGL207W |
Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) |
physical |
3 |
3 |
2 |
Affinity Capture-Western, Reconstituted Complex, Affinity Capture-MS |
| ESA1 |
YOR244W |
Catalytic subunit of the histone acetyltransferase complex (NuA4) |
genetic |
3 |
2 |
2 |
Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic |
| DUN1 |
YDL101C |
Cell-cycle checkpoint S/T protein kinase |
genetic |
3 |
2 |
2 |
Phenotypic Suppression, Synthetic Growth Defect, Synthetic Growth Defect |
| YAP1 |
YML007W |
Basic leucine zipper (bZIP) transcription factor |
genetic |
3 |
2 |
2 |
Negative Genetic, Negative Genetic, Synthetic Growth Defect |
| CDC48 |
YDL126C |
AAA ATPase with protein-unfoldase activity |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| PAC11 |
YDR488C |
Dynein intermediate chain, microtubule motor protein |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| SMI1 |
YGR229C |
Protein involved in the regulation of cell wall synthesis |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| COX23 |
YHR116W |
Protein that functions in mitochondrial copper homeostasis |
genetic |
3 |
1 |
2 |
Positive Genetic, Positive Genetic, Positive Genetic |
| APQ12 |
YIL040W |
Nuclear envelope/ER integral membrane protein |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| MEC1 |
YBR136W |
Genome integrity checkpoint protein and PI kinase superfamily member |
genetic |
2 |
2 |
2 |
Phenotypic Suppression, Synthetic Rescue |
| RAD51 |
YER095W |
Strand exchange protein |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Negative Genetic |
| RAD54 |
YGL163C |
DNA-dependent ATPase that stimulates strand exchange |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Positive Genetic |
| CTF4 |
YPR135W |
Chromatin-associated protein |
genetic |
2 |
2 |
2 |
Positive Genetic, Synthetic Rescue |
| RAD53 |
YPL153C |
DNA damage response kinase |
genetic |
2 |
2 |
2 |
Phenotypic Suppression, Positive Genetic |
| MMS22 |
YLR320W |
Subunit of E3 ubiquitin ligase complex involved in replication repair |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Positive Genetic |
| CDC34 |
YDR054C |
Ubiquitin-conjugating enzyme (E2) |
physical |
2 |
2 |
2 |
Affinity Capture-MS, Reconstituted Complex |
| SKN7 |
YHR206W |
Nuclear response regulator and transcription factor |
genetic |
2 |
2 |
2 |
Negative Genetic, Synthetic Growth Defect |
| TOP1 |
YOL006C |
Topoisomerase I |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Synthetic Rescue |
| CRT10 |
YOL063C |
Protein required for the degradation of mutant 25S rRNAs |
physical |
2 |
2 |
2 |
Affinity Capture-Western, Affinity Capture-MS |
| CDC73 |
YLR418C |
Component of the Paf1p complex |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| CTK1 |
YKL139W |
Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I) |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| HSL1 |
YKL101W |
Nim1p-related protein kinase |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| RTS1 |
YOR014W |
B-type regulatory subunit of protein phosphatase 2A (PP2A) |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| NUP84 |
YDL116W |
Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| LTE1 |
YAL024C |
Protein similar to GDP/GTP exchange factors |
genetic |
2 |
1 |
2 |
Synthetic Growth Defect, Synthetic Growth Defect |
| GET2 |
YER083C |
Subunit of the GET complex |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| RAD50 |
YNL250W |
Subunit of MRX complex with Mre11p and Xrs2p |
genetic |
2 |
1 |
2 |
Synthetic Growth Defect, Synthetic Growth Defect |
| RTG3 |
YBL103C |
bHLH/Zip transcription factor for retrograde (RTG) and TOR pathways |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| CTF8 |
YHR191C |
Subunit of a complex with Ctf18p |
genetic |
2 |
1 |
2 |
Positive Genetic, Positive Genetic |
| MMS1 |
YPR164W |
Subunit of E3 ubiquitin ligase complex involved in replication repair |
genetic |
2 |
1 |
2 |
Positive Genetic, Positive Genetic |
| HRQ1 |
YDR291W |
3'-5' DNA helicase of the conserved RecQ family |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| KCS1 |
YDR017C |
Inositol hexakisphosphate and inositol heptakisphosphate kinase |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| SRS2 |
YJL092W |
DNA helicase and DNA-dependent ATPase |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| SCC2 |
YDR180W |
Subunit of cohesin loading factor (Scc2p-Scc4p) |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| TAP42 |
YMR028W |
Essential protein involved in the TOR signaling pathway |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| AIM34 |
YMR003W |
Protein of unknown function |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| PPM1 |
YDR435C |
Carboxyl methyltransferase |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| POP2 |
YNR052C |
Subunit of Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation |
genetic |
2 |
2 |
1 |
Synthetic Growth Defect, Synthetic Lethality |
| ECO1 |
YFR027W |
Acetyltransferase required for sister chromatid cohesion |
genetic |
2 |
2 |
1 |
Synthetic Lethality, Dosage Rescue |
| RAD57 |
YDR004W |
Protein that stimulates strand exchange |
genetic |
2 |
2 |
1 |
Negative Genetic, Positive Genetic |
| CCR4 |
YAL021C |
Component of the CCR4-NOT transcriptional complex |
genetic |
2 |
1 |
1 |
Synthetic Growth Defect, Synthetic Growth Defect |
| ARD1 |
YHR013C |
Subunit of protein N-terminal acetyltransferase NatA |
genetic |
2 |
1 |
1 |
Synthetic Growth Defect, Synthetic Growth Defect |
| HDA1 |
YNL021W |
Catalytic subunit of class II HDA1 histone deacetylase complex |
genetic |
2 |
1 |
1 |
Dosage Lethality, Dosage Lethality |
| DPB4 |
YDR121W |
Subunit of DNA pol epsilon and of ISW2 chromatin accessibility complex |
genetic |
2 |
1 |
1 |
Synthetic Rescue, Synthetic Rescue |
| HOM6 |
YJR139C |
Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase) |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| DBF4 |
YDR052C |
Regulatory subunit of Cdc7p-Dbf4p kinase complex |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| POL32 |
YJR043C |
Third subunit of DNA polymerase delta |
genetic |
2 |
1 |
1 |
Synthetic Rescue, Synthetic Rescue |
| CCS1 |
YMR038C |
Copper chaperone for superoxide dismutase Sod1p |
genetic |
2 |
1 |
1 |
Synthetic Growth Defect, Synthetic Growth Defect |
| ESC2 |
YDR363W |
Sumo-like domain protein |
physical |
2 |
1 |
1 |
Affinity Capture-Western, Affinity Capture-Western |
| MPS3 |
YJL019W |
Nuclear envelope protein |
genetic |
2 |
1 |
1 |
Synthetic Growth Defect, Synthetic Growth Defect |
| FKH1 |
YIL131C |
Forkhead family transcription factor |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| CDC40 |
YDR364C |
Pre-mRNA splicing factor |
genetic |
1 |
1 |
1 |
Positive Genetic |
| CTF3 |
YLR381W |
Outer kinetochore protein that forms a complex with Mcm16p and Mcm22p |
genetic |
1 |
1 |
1 |
Positive Genetic |
| RPO21 |
YDL140C |
RNA polymerase II largest subunit B220 |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CKA2 |
YOR061W |
Alpha' catalytic subunit of casein kinase 2 (CK2) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| EAF1 |
YDR359C |
Component of the NuA4 histone acetyltransferase complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| NOP2 |
YNL061W |
rRNA m5C methyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RSM23 |
YGL129C |
Mitochondrial ribosomal protein of the small subunit |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| KAP123 |
YER110C |
Karyopherin beta |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RIC1 |
YLR039C |
Protein involved in retrograde transport to the cis-Golgi network |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PRP46 |
YPL151C |
Member of the NineTeen Complex (NTC) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| BRE1 |
YDL074C |
E3 ubiquitin ligase |
genetic |
1 |
1 |
1 |
Positive Genetic |
| POL5 |
YEL055C |
Protein involved in 60S assembly and pre-40S AFs recycling |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ARC1 |
YGL105W |
Protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases |
genetic |
1 |
1 |
1 |
Negative Genetic |
| LSM3 |
YLR438C-A |
Lsm (Like Sm) protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CSL4 |
YNL232W |
Exosome non-catalytic core component |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RRP6 |
YOR001W |
Nuclear exosome exonuclease component |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PSY2 |
YNL201C |
Subunit of protein phosphatase PP4 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPC34 |
YNR003C |
RNA polymerase III subunit C34 |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NPL6 |
YMR091C |
Component of the RSC chromatin remodeling complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| MED4 |
YOR174W |
Subunit of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPN5 |
YDL147W |
Subunit of the CSN and 26S proteasome lid complexes |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPN6 |
YDL097C |
Essential, non-ATPase regulatory subunit of the 26S proteasome lid |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPN8 |
YOR261C |
Essential non-ATPase regulatory subunit of the 26S proteasome |
genetic |
1 |
1 |
1 |
Negative Genetic |
| KAP95 |
YLR347C |
Karyopherin beta |
genetic |
1 |
1 |
1 |
Positive Genetic |
| NAB2 |
YGL122C |
Nuclear polyadenylated RNA-binding protein |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| REB1 |
YBR049C |
RNA polymerase I enhancer binding protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| BEM1 |
YBR200W |
Protein containing SH3-domains |
genetic |
1 |
1 |
1 |
Positive Genetic |
| BUD14 |
YAR014C |
Protein involved in bud-site selection |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CDC3 |
YLR314C |
Component of the septin ring that is required for cytokinesis |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CDC55 |
YGL190C |
Regulatory subunit B of protein phosphatase 2A (PP2A) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CEG1 |
YGL130W |
Guanylyltransferase involved in mRNA 5' capping |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CKS1 |
YBR135W |
Cyclin-dependent protein kinase regulatory subunit and adaptor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DNA2 |
YHR164C |
ATP-dependent 5'-flap endonuclease and DNA helicase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CIA2 |
YHR122W |
Component of cytosolic iron-sulfur protein assembly (CIA) machinery |
genetic |
1 |
1 |
1 |
Negative Genetic |
| HHF1 |
YBR009C |
Histone H4 |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| HHF2 |
YNL030W |
Histone H4 |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
| ISW1 |
YBR245C |
ATPase subunit of imitation-switch (ISWI) class chromatin remodelers |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| CRM1 |
YGR218W |
Nuclear export factor, exportin |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| MCM6 |
YGL201C |
Protein involved in DNA replication |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| MED11 |
YMR112C |
Subunit of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| FAB1 |
YFR019W |
1-phosphatidylinositol-3-phosphate 5-kinase |
genetic |
1 |
1 |
1 |
Positive Genetic |
| LCD1 |
YDR499W |
Essential protein required for the DNA integrity checkpoint pathways |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
| MPH1 |
YIR002C |
3'-5' DNA helicase involved in error-free bypass of DNA lesions |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PEP3 |
YLR148W |
Component of CORVET membrane tethering complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| PRE4 |
YFR050C |
Beta 7 subunit of the 20S proteasome |
physical |
1 |
1 |
1 |
Two-hybrid |
| HTA2 |
YBL003C |
Histone H2A |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| RFA1 |
YAR007C |
Subunit of heterotrimeric Replication Protein A (RPA) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RFC1 |
YOR217W |
Subunit of heteropentameric Replication factor C (RF-C) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MED8 |
YBR193C |
Subunit of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NUP120 |
YKL057C |
Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| HRK1 |
YOR267C |
Protein kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| HEM13 |
YDR044W |
Coproporphyrinogen III oxidase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PSK1 |
YAL017W |
PAS domain-containing serine/threonine protein kinase |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| RRD2 |
YPL152W |
Peptidyl-prolyl cis/trans-isomerase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| BCK1 |
YJL095W |
MAPKKK acting in the protein kinase C signaling pathway |
genetic |
1 |
1 |
1 |
Negative Genetic |
| AAC3 |
YBR085W |
Mitochondrial inner membrane ADP/ATP translocator |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CDC53 |
YDL132W |
Cullin |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PPZ2 |
YDR436W |
Serine/threonine protein phosphatase Z, isoform of Ppz1p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| GLC8 |
YMR311C |
Regulatory subunit of protein phosphatase 1 (Glc7p) |
genetic |
1 |
1 |
1 |
Positive Genetic |
| CDC9 |
YDL164C |
DNA ligase I found in nucleus and mitochondria |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RAD55 |
YDR076W |
Protein that stimulates strand exchange |
genetic |
1 |
1 |
1 |
Positive Genetic |
| ELM1 |
YKL048C |
Serine/threonine protein kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RAD6 |
YGL058W |
Ubiquitin-conjugating enzyme (E2) |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| PRM2 |
YIL037C |
Pheromone-regulated protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| LRO1 |
YNR008W |
Acyltransferase that converts diacylglycerol to triacylglycerol (TGA) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RAD24 |
YER173W |
Checkpoint protein |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| HHT1 |
YBR010W |
Histone H3 |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| CTF4 |
YPR135W |
Chromatin-associated protein |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
| MRE11 |
YMR224C |
Nuclease subunit of the MRX complex with Rad50p and Xrs2p |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| RAD59 |
YDL059C |
Protein involved DNA double-strand break repair |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CIK1 |
YMR198W |
Kinesin-associated protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ELG1 |
YOR144C |
Subunit of an alternative replication factor C complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MEH1 |
YKR007W |
Subunit of the EGO/GSE complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CPR3 |
YML078W |
Mitochondrial peptidyl-prolyl cis-trans isomerase (cyclophilin) |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| BUB3 |
YOR026W |
Kinetochore checkpoint WD40 repeat protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MUS81 |
YDR386W |
Subunit of structure-specific Mms4p-Mus81p endonuclease |
genetic |
1 |
1 |
1 |
Positive Genetic |
| MMS4 |
YBR098W |
Subunit of structure-specific Mms4p-Mus81p endonuclease |
genetic |
1 |
1 |
1 |
Negative Genetic |
| FUS3 |
YBL016W |
Mitogen-activated serine/threonine protein kinase involved in mating |
genetic |
1 |
1 |
1 |
Negative Genetic |
| BIR1 |
YJR089W |
Subunit of chromosomal passenger complex (CPC) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| AFG3 |
YER017C |
Mitochondrial inner membrane m-AAA protease component |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| CTK3 |
YML112W |
Gamma subunit of C-terminal domain kinase I |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MTQ2 |
YDR140W |
S-adenosylmethionine-dependent methyltransferase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| CSM2 |
YIL132C |
Subunit of the Shu complex (aka PCSS complex) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CSM1 |
YCR086W |
Nucleolar protein that mediates homolog segregation during meiosis I |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| MCM10 |
YIL150C |
Essential chromatin-associated protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| IPK1 |
YDR315C |
Inositol 1,3,4,5,6-pentakisphosphate 2-kinase |
genetic |
1 |
1 |
1 |
Positive Genetic |
| MAD2 |
YJL030W |
Component of the spindle-assembly checkpoint complex |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| MSN5 |
YDR335W |
Karyopherin |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CSM3 |
YMR048W |
Replication fork associated factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NST1 |
YNL091W |
Translational inhibitor and suppressor of proteasome-assembly defects |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DOC1 |
YGL240W |
Processivity factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| GRC3 |
YLL035W |
Polynucleotide kinase present on rDNA |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPS13 |
YDR064W |
Protein component of the small (40S) ribosomal subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| RPS5 |
YJR123W |
Protein component of the small (40S) ribosomal subunit |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| NFI1 |
YOR156C |
SUMO E3 ligase |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| RPS7A |
YOR096W |
Protein component of the small (40S) ribosomal subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| MOT2 |
YER068W |
Ubiquitin-protein ligase subunit of the CCR4-NOT complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| KAR3 |
YPR141C |
Minus-end-directed microtubule motor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RAD5 |
YLR032W |
DNA helicase/Ubiquitin ligase |
genetic |
1 |
1 |
1 |
Positive Genetic |
| RAP1 |
YNL216W |
Essential DNA-binding transcription regulator that binds many loci |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CSG2 |
YBR036C |
Endoplasmic reticulum membrane protein |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| POL3 |
YDL102W |
Catalytic subunit of DNA polymerase delta |
genetic |
1 |
1 |
1 |
Negative Genetic |
| POL31 |
YJR006W |
Subunit of DNA polymerase delta (polymerase III) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RRI2 |
YOL117W |
Subunit of the COP9 signalosome (CSN) complex |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| CAD1 |
YDR423C |
AP-1-like basic leucine zipper (bZIP) transcriptional activator |
genetic |
1 |
1 |
1 |
Negative Genetic |
| GNT1 |
YOR320C |
N-acetylglucosaminyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ORC5 |
YNL261W |
Subunit of the origin recognition complex (ORC) |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
| RPL31A |
YDL075W |
Ribosomal 60S subunit protein L31A |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| OAF1 |
YAL051W |
Oleate-activated transcription factor |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| HHT2 |
YNL031C |
Histone H3 |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
| RPS2 |
YGL123W |
Protein component of the small (40S) subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| RPS3 |
YNL178W |
Protein component of the small (40S) ribosomal subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| KAP120 |
YPL125W |
Karyopherin responsible for the nuclear import of Rpf1p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CLB3 |
YDL155W |
B-type cyclin involved in cell cycle progression |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MON2 |
YNL297C |
Protein with a role in endocytosis and vacuole integrity |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| RPS20 |
YHL015W |
Protein component of the small (40S) ribosomal subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| RPS0A |
YGR214W |
Ribosomal 40S subunit protein S0A |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| RPS18A |
YDR450W |
Protein component of the small (40S) ribosomal subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| HSP26 |
YBR072W |
Small heat shock protein (sHSP) with chaperone activity |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| RMI1 |
YPL024W |
Subunit of the RecQ (Sgs1p) - Topo III (Top3p) complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DCC1 |
YCL016C |
Subunit of a complex with Ctf8p and Ctf18p |
genetic |
1 |
1 |
1 |
Positive Genetic |
| FCF2 |
YLR051C |
Nucleolar protein involved in the early steps of 35S rRNA processing |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PDC2 |
YDR081C |
Transcription factor for thiamine-regulated genes |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YEL1 |
YBL060W |
Guanine nucleotide exchange factor specific for Arf3p |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| STM1 |
YLR150W |
Protein required for optimal translation under nutrient stress |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| YPL216W |
YPL216W |
Putative protein of unknown function |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| SPT16 |
YGL207W |
Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| SSB2 |
YNL209W |
Cytoplasmic ATPase that is a ribosome-associated molecular chaperone |
physical |
1 |
1 |
1 |
Co-purification |
| SLD5 |
YDR489W |
Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
| SMC6 |
YLR383W |
Subunit of the SMC5-SMC6 complex |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| TOP3 |
YLR234W |
DNA Topoisomerase III |
genetic |
1 |
1 |
1 |
Negative Genetic |
| VPH2 |
YKL119C |
Integral membrane protein required for V-ATPase function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SEM1 |
YDR363W-A |
19S proteasome regulatory particle lid subcomplex component |
genetic |
1 |
1 |
1 |
Negative Genetic |
| VID22 |
YLR373C |
G-quadruplex (G4) DNA binding protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SRB8 |
YCR081W |
Subunit of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SML1 |
YML058W |
Ribonucleotide reductase inhibitor |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| SEH1 |
YGL100W |
Subunit of the Nup84 nuclear pore and SEACAT subcomplexes |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TPS1 |
YBR126C |
Synthase subunit of trehalose-6-P synthase/phosphatase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SSN3 |
YPL042C |
Component of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| STU1 |
YBL034C |
Microtubule plus-end-tracking non-motor protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YHC1 |
YLR298C |
Component of the U1 snRNP complex required for pre-mRNA splicing |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SEC63 |
YOR254C |
Essential subunit of Sec63 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SLX8 |
YER116C |
Subunit of Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| SWI6 |
YLR182W |
Transcription cofactor |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| STP22 |
YCL008C |
Component of the ESCRT-I complex |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| TTI1 |
YKL033W |
Subunit of the ASTRA complex, involved in chromatin remodeling |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SRP40 |
YKR092C |
Nucleolar serine-rich protein |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| YML083C |
YML083C |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| YML079W |
YML079W |
Non-essential protein of unknown function |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| YML082W |
YML082W |
Putative protein predicted to have carbon-sulfur lyase activity |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| UFO1 |
YML088W |
F-box receptor protein |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| TDA9 |
YML081W |
Transcription factor that regulates acetate production |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| YLR358C |
YLR358C |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| VPS54 |
YDR027C |
Component of the GARP (Golgi-associated retrograde protein) complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| TIP20 |
YGL145W |
Peripheral membrane protein required for COPI vesicle fusion to the ER |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TAM41 |
YGR046W |
Mitochondrial phosphatidate cytidylyltransferase (CDP-DAG synthase) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| WRS1 |
YOL097C |
Cytoplasmic tryptophanyl-tRNA synthetase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TIF6 |
YPR016C |
Constituent of 66S pre-ribosomal particles |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SGV1 |
YPR161C |
Cyclin (Bur2p)-dependent protein kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SMT3 |
YDR510W |
Ubiquitin-like protein of the SUMO family |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SHP1 |
YBL058W |
UBX domain-containing substrate adaptor for Cdc48p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| UMP1 |
YBR173C |
Chaperone required for correct maturation of the 20S proteasome |
genetic |
1 |
1 |
1 |
Negative Genetic |
| VMA9 |
YCL005W-A |
Vacuolar H+ ATPase subunit e of the V-ATPase V0 subcomplex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RVS161 |
YCR009C |
Amphiphysin-like lipid raft protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TMA64 |
YDR117C |
Protein of unknown function that associates with ribosomes |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SUM1 |
YDR310C |
Transcriptional repressor that regulates middle-sporulation genes |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ZNF1 |
YFL052W |
Zinc cluster transcription factor that regulates respiratory growth |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YGR237C |
YGR237C |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YMR155W |
YMR155W |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YKU80 |
YMR106C |
Subunit of telomeric Ku complex (Yku70p-Yku80p) |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| RTT109 |
YLL002W |
Histone acetyltransferase |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| RTT106 |
YNL206C |
Histone chaperone |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| SIR2 |
YDL042C |
Conserved NAD+ dependent histone deacetylase of the Sirtuin family |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| SAS2 |
YMR127C |
Histone acetyltransferase (HAT) catalytic subunit of the SAS complex |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| GCD14 |
YJL125C |
Subunit of tRNA (1-methyladenosine) methyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RIA1 |
YNL163C |
Cytoplasmic GTPase/eEF2-like factor involved in ribosomal biogenesis |
genetic |
1 |
1 |
1 |
Positive Genetic |
| RNH201 |
YNL072W |
Ribonuclease H2 catalytic subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PSP2 |
YML017W |
Asn rich cytoplasmic protein that contains RGG motifs |
genetic |
1 |
1 |
1 |
Negative Genetic |
| LAG2 |
YOL025W |
Protein that negatively regulates the SCF E3-ubiquitin ligase |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| GLN4 |
YOR168W |
Glutamine tRNA synthetase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPS6A |
YPL090C |
Protein component of the small (40S) ribosomal subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| RPS10A |
YOR293W |
Protein component of the small (40S) ribosomal subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| RPL26A |
YLR344W |
Ribosomal 60S subunit protein L26A |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| RPS12 |
YOR369C |
Protein component of the small (40S) ribosomal subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| RPS19A |
YOL121C |
Protein component of the small (40S) ribosomal subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| GPI12 |
YMR281W |
ER membrane protein involved in the second step of GPI anchor assembly |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DUS1 |
YML080W |
Dihydrouridine synthase |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| PDX3 |
YBR035C |
Pyridoxine (pyridoxamine) phosphate oxidase |
genetic |
1 |
1 |
1 |
Positive Genetic |
| PHO91 |
YNR013C |
Low-affinity vacuolar phosphate transporter |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ALO1 |
YML086C |
D-Arabinono-1,4-lactone oxidase |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| MET7 |
YOR241W |
Folylpolyglutamate synthetase |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| RTC1 |
YOL138C |
Subunit of SEACAT, a subcomplex of the SEA complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ADK2 |
YER170W |
Mitochondrial adenylate kinase |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| RPL39 |
YJL189W |
Ribosomal 60S subunit protein L39 |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| COS10 |
YNR075W |
Endosomal protein involved in turnover of plasma membrane proteins |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DFG10 |
YIL049W |
Probable polyprenol reductase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MIC12 |
YBR262C |
Component of the MICOS complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPS15 |
YOL040C |
Protein component of the small (40S) ribosomal subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| AIM33 |
YML087C |
Protein of unknown function, highly conserved across species |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| PAN6 |
YIL145C |
Pantothenate synthase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PCP1 |
YGR101W |
Mitochondrial serine protease |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| RAD61 |
YDR014W |
Subunit of a complex that inhibits sister chromatid cohesion |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PHM7 |
YOL084W |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Positive Genetic |
| ECM23 |
YPL021W |
Non-essential protein of unconfirmed function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MIN10 |
YFR032C-B |
Mitochondrial protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
