Standard name Systematic name Name description Description
SML1 YML058W Ribonucleotide reductase inhibitor Ribonucleotide reductase inhibitor; involved in regulating dNTP production; regulated by Mec1p and Rad53p during DNA damage and S phase; SML1 has a paralog, DIF1, that arose from the whole genome duplication
Visualize the interactome of SML1
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)
G1(P) 21

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.996 0.992 0.988

GFP localization & abundance

GFP localization GFP abundance
cytoplasm, nucleus 18800

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
SML1 0 0 0 0 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
MEC1 YBR136W Genome integrity checkpoint protein and PI kinase superfamily member genetic 26 4 26 Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Rescue, Synthetic Rescue, Phenotypic Enhancement, Synthetic Rescue, Synthetic Rescue, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Suppression, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Phenotypic Enhancement, Synthetic Rescue, Synthetic Rescue, Phenotypic Suppression
RAD53 YPL153C DNA damage response kinase genetic 20 5 20 Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Rescue, Synthetic Rescue, Phenotypic Enhancement, Synthetic Rescue, Phenotypic Suppression, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Rescue, Phenotypic Enhancement, Synthetic Rescue, Synthetic Rescue, Phenotypic Suppression, Synthetic Lethality, Synthetic Rescue, Synthetic Lethality, Phenotypic Enhancement, Synthetic Rescue, Synthetic Rescue
DUN1 YDL101C Cell-cycle checkpoint S/T protein kinase genetic 14 5 13 Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Rescue, Phenotypic Enhancement, Phenotypic Suppression, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Dosage Growth Defect, Synthetic Rescue, Synthetic Rescue, Phenotypic Suppression, Phenotypic Suppression
DUN1 YDL101C Cell-cycle checkpoint S/T protein kinase physical 8 3 7 Affinity Capture-MS, Two-hybrid, Two-hybrid, Biochemical Activity, Biochemical Activity, Biochemical Activity, Biochemical Activity, Biochemical Activity
LCD1 YDR499W Essential protein required for the DNA integrity checkpoint pathways genetic 6 3 5 Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Lethality, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue
RNR1 YER070W Major isoform of large subunit of ribonucleotide-diphosphate reductase physical 6 3 5 Affinity Capture-Western, Two-hybrid, Two-hybrid, Two-hybrid, Reconstituted Complex, Reconstituted Complex
RAD9 YDR217C DNA damage-dependent checkpoint protein genetic 5 1 5 Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue
MRC1 YCL061C S-phase checkpoint protein required for DNA replication genetic 5 1 5 Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue
TEL1 YBL088C Protein kinase primarily involved in telomere length regulation genetic 5 3 4 Dosage Rescue, Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Growth Defect
PIF1 YML061C DNA helicase, potent G-quadruplex DNA binder/unwinder genetic 4 3 3 Phenotypic Enhancement, Phenotypic Suppression, Phenotypic Suppression, Synthetic Rescue
REV1 YOR346W Deoxycytidyl transferase physical 4 3 2 Affinity Capture-MS, Two-hybrid, Affinity Capture-Western, Affinity Capture-Western
FKH2 YNL068C Forkhead family transcription factor regulation 3 3 3 chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation- exonuclease evidence, ChEC-Seq experiments
MIP1 YOR330C Mitochondrial DNA polymerase gamma genetic 3 3 3 Synthetic Rescue, Phenotypic Suppression, Phenotypic Enhancement
RRM3 YHR031C DNA helicase involved in rDNA replication and Ty1 transposition genetic 3 3 2 Synthetic Lethality, Phenotypic Suppression, Synthetic Rescue
APN1 YKL114C Major apurinic/apyrimidinic endonuclease genetic 3 2 2 Synthetic Lethality, Synthetic Rescue, Synthetic Rescue
SML1 YML058W Ribonucleotide reductase inhibitor physical 3 2 2 Reconstituted Complex, Co-crystal Structure, Reconstituted Complex
REB1 YBR049C RNA polymerase I enhancer binding protein regulation 2 2 2 chromatin immunoprecipitation-chip evidence, DNA to cDNA expression microarray evidence
RAD51 YER095W Strand exchange protein genetic 2 2 2 Phenotypic Enhancement, Synthetic Rescue
CHK1 YBR274W Serine/threonine kinase and DNA damage checkpoint effector genetic 2 2 2 Phenotypic Enhancement, Synthetic Rescue
HHT1 YBR010W Histone H3 genetic 2 2 2 Dosage Lethality, Synthetic Rescue
DIF1 YLR437C Protein that regulates nuclear import of Rnr2p and Rnr4p genetic 2 2 2 Dosage Growth Defect, Phenotypic Enhancement
FKH1 YIL131C Forkhead family transcription factor regulation 2 1 2 chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation-chip evidence
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 2 1 2 Affinity Capture-RNA, Affinity Capture-RNA
DIA2 YOR080W Origin-binding F-box protein genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
PAC1 YOR269W Regulator of dynein, involved in intracellular transport genetic 2 1 2 Negative Genetic, Negative Genetic
RNR1 YER070W Major isoform of large subunit of ribonucleotide-diphosphate reductase genetic 2 2 1 Synthetic Rescue, Synthetic Lethality
TSA1 YML028W Thioredoxin peroxidase genetic 2 2 1 Synthetic Rescue, Phenotypic Enhancement
APN2 YBL019W Class II abasic (AP) endonuclease involved in repair of DNA damage genetic 2 2 1 Synthetic Lethality, Synthetic Rescue
SWS2 YNL081C Putative mitochondrial ribosomal protein of the small subunit genetic 2 1 1 Negative Genetic, Negative Genetic
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
RFX1 YLR176C Major transcriptional repressor of DNA-damage-regulated genes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
RAP1 YNL216W Essential DNA-binding transcription regulator that binds many loci regulation 1 1 1 DNA to cDNA expression microarray evidence
SPT3 YDR392W Subunit of the SAGA and SAGA-like transcriptional regulatory complexes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SWI4 YER111C DNA binding component of the SBF complex (Swi4p-Swi6p) regulation 1 1 1 chromatin immunoprecipitation-chip evidence
UME6 YDR207C Rpd3L histone deacetylase complex subunit regulation 1 1 1 chromatin immunoprecipitation-chip evidence
DUN1 YDL101C Cell-cycle checkpoint S/T protein kinase regulation 1 1 1 protein kinase assay evidence
CDC73 YLR418C Component of the Paf1p complex genetic 1 1 1 Negative Genetic
RPO21 YDL140C RNA polymerase II largest subunit B220 genetic 1 1 1 Synthetic Lethality
HPR1 YDR138W Subunit of THO/TREX complexes genetic 1 1 1 Synthetic Growth Defect
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
APC1 YNL172W Largest subunit of the Anaphase-Promoting Complex/Cyclosome physical 1 1 1 Affinity Capture-MS
CDC24 YAL041W Guanine nucleotide exchange factor (GEF) for Cdc42p genetic 1 1 1 Negative Genetic
CDC45 YLR103C DNA replication initiation factor genetic 1 1 1 Phenotypic Suppression
DNA2 YHR164C ATP-dependent 5'-flap endonuclease and DNA helicase genetic 1 1 1 Dosage Rescue
AEP2 YMR282C Mitochondrial protein genetic 1 1 1 Positive Genetic
ISW2 YOR304W ATP-dependent DNA translocase involved in chromatin remodeling genetic 1 1 1 Synthetic Rescue
IMG1 YCR046C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
MRP49 YKL167C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
HTZ1 YOL012C Histone variant H2AZ genetic 1 1 1 Synthetic Growth Defect
NHP10 YDL002C Non-essential INO80 chromatin remodeling complex subunit genetic 1 1 1 Synthetic Rescue
DOA4 YDR069C Ubiquitin hydrolase genetic 1 1 1 Dosage Rescue
PEP3 YLR148W Component of CORVET membrane tethering complex physical 1 1 1 Affinity Capture-MS
PFK1 YGR240C Alpha subunit of heterooctameric phosphofructokinase physical 1 1 1 Affinity Capture-MS
POL2 YNL262W Catalytic subunit of DNA polymerase (II) epsilon genetic 1 1 1 Synthetic Rescue
RAD23 YEL037C Protein with ubiquitin-like N terminus genetic 1 1 1 Synthetic Rescue
RAD52 YML032C Protein involved in homologous recombination genetic 1 1 1 Synthetic Rescue
RPD3 YNL330C Histone deacetylase, component of both the Rpd3S and Rpd3L complexes genetic 1 1 1 Phenotypic Suppression
RTS1 YOR014W B-type regulatory subunit of protein phosphatase 2A (PP2A) genetic 1 1 1 Negative Genetic
SIN3 YOL004W Component of both the Rpd3S and Rpd3L histone deacetylase complexes genetic 1 1 1 Negative Genetic
NAT1 YDL040C Subunit of protein N-terminal acetyltransferase NatA physical 1 1 1 Affinity Capture-MS
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes genetic 1 1 1 Synthetic Growth Defect
SEN1 YLR430W ATP-dependent 5' to 3' RNA/DNA and DNA helicase genetic 1 1 1 Synthetic Growth Defect
NEW1 YPL226W Translation termination and ribosome biogenesis factor genetic 1 1 1 Negative Genetic
RAV1 YJR033C Subunit of RAVE complex (Rav1p, Rav2p, Skp1p) genetic 1 1 1 Negative Genetic
RAD1 YPL022W Single-stranded DNA endonuclease (with Rad10p) genetic 1 1 1 Synthetic Rescue
SET1 YHR119W Histone methyltransferase, subunit of the COMPASS (Set1C) complex genetic 1 1 1 Synthetic Rescue
HEK2 YBL032W RNA binding protein involved in asymmetric localization of ASH1 mRNA physical 1 1 1 Affinity Capture-RNA
RRP12 YPL012W Protein required for export of the ribosomal subunits genetic 1 1 1 Synthetic Rescue
CDC13 YDL220C Single stranded DNA-binding protein found at TG1-3 telomere G-tails genetic 1 1 1 Synthetic Rescue
GPH1 YPR160W Glycogen phosphorylase required for the mobilization of glycogen physical 1 1 1 Affinity Capture-MS
FET4 YMR319C Low-affinity Fe(II) transporter of the plasma membrane genetic 1 1 1 Synthetic Rescue
ATP3 YBR039W Gamma subunit of the F1 sector of mitochondrial F1F0 ATP synthase physical 1 1 1 Affinity Capture-MS
PYC1 YGL062W Pyruvate carboxylase isoform physical 1 1 1 Affinity Capture-MS
PHO85 YPL031C Cyclin-dependent kinase physical 1 1 1 Biochemical Activity
RNR2 YJL026W Ribonucleotide-diphosphate reductase (RNR), small subunit genetic 1 1 1 Phenotypic Enhancement
AAC3 YBR085W Mitochondrial inner membrane ADP/ATP translocator physical 1 1 1 Affinity Capture-MS
BUB2 YMR055C Mitotic exit network regulator genetic 1 1 1 Phenotypic Suppression
HIR3 YJR140C Subunit of the HIR complex physical 1 1 1 Affinity Capture-MS
FET3 YMR058W Ferro-O2-oxidoreductase genetic 1 1 1 Synthetic Rescue
BFA1 YJR053W Subunit of a two-component GTPase-activating protein, Bfa1p-Bub2p genetic 1 1 1 Phenotypic Suppression
ECM10 YEL030W Heat shock protein of the Hsp70 family physical 1 1 1 Affinity Capture-MS
GPP2 YER062C DL-glycerol-3-phosphate phosphatase involved in glycerol biosynthesis physical 1 1 1 Affinity Capture-MS
ADH3 YMR083W Mitochondrial alcohol dehydrogenase isozyme III physical 1 1 1 Affinity Capture-MS
RNQ1 YCL028W [PIN(+)] prion physical 1 1 1 Affinity Capture-MS
CAT5 YOR125C Protein required for ubiquinone (Coenzyme Q) biosynthesis genetic 1 1 1 Negative Genetic
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 1 1 1 Positive Genetic
BEM3 YPL115C Rho GTPase activating protein (RhoGAP) physical 1 1 1 Affinity Capture-MS
SLD2 YKL108W Single-stranded DNA origin-binding and annealing protein genetic 1 1 1 Phenotypic Suppression
IRA1 YBR140C GTPase-activating protein physical 1 1 1 Affinity Capture-MS
MEK1 YOR351C Meiosis-specific serine/threonine protein kinase physical 1 1 1 Biochemical Activity
DPB11 YJL090C DNA replication initiation protein genetic 1 1 1 Phenotypic Suppression
RAD59 YDL059C Protein involved DNA double-strand break repair genetic 1 1 1 Phenotypic Enhancement
NTG1 YAL015C DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase genetic 1 1 1 Phenotypic Suppression
RAD7 YJR052W Nucleotide excision repair (NER) protein genetic 1 1 1 Synthetic Rescue
ELG1 YOR144C Subunit of an alternative replication factor C complex genetic 1 1 1 Phenotypic Enhancement
MCK1 YNL307C Dual-specificity ser/thr and tyrosine protein kinase physical 1 1 1 Biochemical Activity
PTC2 YER089C Type 2C protein phosphatase (PP2C) genetic 1 1 1 Synthetic Rescue
RAD53 YPL153C DNA damage response kinase physical 1 1 1 Affinity Capture-Western
MMS4 YBR098W Subunit of structure-specific Mms4p-Mus81p endonuclease genetic 1 1 1 Phenotypic Suppression
RNR3 YIL066C Minor isoform of large subunit of ribonucleotide-diphosphate reductase physical 1 1 1 Two-hybrid
ATP7 YKL016C Subunit d of the stator stalk of mitochondrial F1F0 ATP synthase genetic 1 1 1 Positive Genetic
HST3 YOR025W Sirtuin, histone H3 deacetylase genetic 1 1 1 Synthetic Lethality
APC9 YLR102C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) physical 1 1 1 Affinity Capture-MS
SAC3 YDR159W mRNA export factor genetic 1 1 1 Synthetic Rescue
CTF8 YHR191C Subunit of a complex with Ctf18p genetic 1 1 1 Negative Genetic
DBF4 YDR052C Regulatory subunit of Cdc7p-Dbf4p kinase complex genetic 1 1 1 Phenotypic Suppression
SEC20 YDR498C Membrane glycoprotein v-SNARE physical 1 1 1 Affinity Capture-MS
MPT5 YGL178W mRNA-binding protein of the PUF family physical 1 1 1 Affinity Capture-RNA
TUB2 YFL037W Beta-tubulin physical 1 1 1 Affinity Capture-MS
SPT6 YGR116W Nucleosome remodeling protein physical 1 1 1 Affinity Capture-MS
ZAP1 YJL056C Zinc-regulated transcription factor physical 1 1 1 Affinity Capture-MS
ZIM17 YNL310C Protein co-chaperone with a zinc finger motif physical 1 1 1 Affinity Capture-MS
TOP1 YOL006C Topoisomerase I physical 1 1 1 Affinity Capture-MS
WHI3 YNL197C RNA binding protein that modulates mRNA stability physical 1 1 1 Protein-RNA
SRO9 YCL037C Cytoplasmic RNA-binding protein physical 1 1 1 Affinity Capture-RNA
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
SNF1 YDR477W AMP-activated S/T protein kinase genetic 1 1 1 Synthetic Growth Defect
SRS2 YJL092W DNA helicase and DNA-dependent ATPase genetic 1 1 1 Synthetic Rescue
WTM2 YOR229W Transcriptional modulator genetic 1 1 1 Dosage Rescue
WTM1 YOR230W Transcriptional modulator genetic 1 1 1 Phenotypic Enhancement
SOD1 YJR104C Cytosolic copper-zinc superoxide dismutase genetic 1 1 1 Synthetic Growth Defect
SPT16 YGL207W Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) genetic 1 1 1 Synthetic Growth Defect
URE2 YNL229C Nitrogen catabolite repression transcriptional regulator genetic 1 1 1 Phenotypic Suppression
TAF1 YGR274C TFIID subunit, involved in RNA pol II transcription initiation genetic 1 1 1 Synthetic Lethality
TRM9 YML014W tRNA methyltransferase genetic 1 1 1 Phenotypic Suppression
TPP1 YMR156C DNA 3'-phosphatase genetic 1 1 1 Synthetic Rescue
YAR029W YAR029W Member of DUP240 gene family but contains no transmembrane domains genetic 1 1 1 Negative Genetic
SRB2 YHR041C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
YKE2 YLR200W Subunit of the heterohexameric Gim/prefoldin protein complex genetic 1 1 1 Negative Genetic
UME6 YDR207C Rpd3L histone deacetylase complex subunit genetic 1 1 1 Phenotypic Enhancement
SPT21 YMR179W Protein with a role in transcriptional silencing genetic 1 1 1 Synthetic Rescue
POL3 YDL102W Catalytic subunit of DNA polymerase delta genetic 1 1 1 Synthetic Lethality
GPR1 YDL035C Plasma membrane G protein coupled receptor (GPCR) genetic 1 1 1 Negative Genetic
NUP42 YDR192C FG-nucleoporin component of central core of the nuclear pore complex physical 1 1 1 Affinity Capture-MS
NIP100 YPL174C Large subunit of the dynactin complex genetic 1 1 1 Negative Genetic
MID1 YNL291C Stretch-activated Ca2+-permeable cation channel physical 1 1 1 Affinity Capture-MS
ARL3 YPL051W ARF-like small GTPase of the RAS superfamily genetic 1 1 1 Negative Genetic
IXR1 YKL032C Transcriptional repressor that regulates hypoxic genes during normoxia genetic 1 1 1 Synthetic Rescue
REV1 YOR346W Deoxycytidyl transferase genetic 1 1 1 Phenotypic Suppression
REV7 YIL139C Accessory subunit of DNA polymerase zeta genetic 1 1 1 Negative Genetic
FMP27 YLR454W Protein with structural similarity to lipid transport protein Vps13p physical 1 1 1 Affinity Capture-MS
RIO1 YOR119C Serine kinase involved in cell cycle regulation and rDNA integrity genetic 1 1 1 Positive Genetic
DCC1 YCL016C Subunit of a complex with Ctf8p and Ctf18p genetic 1 1 1 Negative Genetic
MRPL11 YDL202W Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
HRQ1 YDR291W 3'-5' DNA helicase of the conserved RecQ family genetic 1 1 1 Positive Genetic
SLF1 YDR515W RNA binding protein that associates with polysomes physical 1 1 1 Affinity Capture-RNA
RTT101 YJL047C Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex genetic 1 1 1 Phenotypic Suppression
KIN4 YOR233W Serine/threonine protein kinase genetic 1 1 1 Phenotypic Suppression
COQ6 YGR255C Flavin-dependent monooxygenase involved in ubiquinone biosynthesis physical 1 1 1 Affinity Capture-MS
AIM26 YKL037W Protein of unknown function physical 1 1 1 Affinity Capture-MS
MDM36 YPR083W Mitochondrial protein physical 1 1 1 Affinity Capture-MS
LIP5 YOR196C Protein involved in biosynthesis of the coenzyme lipoic acid genetic 1 1 1 Negative Genetic
MUB1 YMR100W MYND domain-containing protein physical 1 1 1 Two-hybrid
SLM3 YDL033C tRNA-specific 2-thiouridylase genetic 1 1 1 Negative Genetic
AIM11 YER093C-A Protein of unknown function genetic 1 1 1 Negative Genetic
HST4 YDR191W NAD(+)-dependent protein deacetylase genetic 1 1 1 Synthetic Lethality
EST2 YLR318W Reverse transcriptase subunit of the telomerase holoenzyme genetic 1 1 1 Synthetic Rescue
LDB18 YLL049W Component of the dynactin complex genetic 1 1 1 Negative Genetic
NDD1 YOR372C Transcriptional activator essential for nuclear division genetic 1 1 1 Synthetic Rescue
HIM1 YDR317W Protein of unknown function involved in DNA repair genetic 1 1 1 Phenotypic Suppression
FLX1 YIL134W Mitochondrial flavin adenine dinucleotide transporter genetic 1 1 1 Negative Genetic
PET8 YNL003C S-adenosylmethionine transporter of the mitochondrial inner membrane genetic 1 1 1 Negative Genetic
SLD3 YGL113W Protein involved in the initiation of DNA replication genetic 1 1 1 Phenotypic Suppression
HMI1 YOL095C Mitochondrial inner membrane localized ATP-dependent DNA helicase genetic 1 1 1 Positive Genetic
RML2 YEL050C Mitochondrial ribosomal protein of the large subunit (L2) genetic 1 1 1 Negative Genetic
MRX4 YPL168W Protein that associates with mitochondrial ribosome genetic 1 1 1 Negative Genetic
RMD9 YGL107C Mitochondrial protein that controls mitochondrial gene expression genetic 1 1 1 Negative Genetic
SLD7 YOR060C Protein with a role in chromosomal DNA replication genetic 1 1 1 Phenotypic Suppression