Standard name Systematic name Name description Description
PEP3 YLR148W Component of CORVET membrane tethering complex Component of CORVET membrane tethering complex; vacuolar peripheral membrane protein that promotes vesicular docking/fusion reactions in conjunction with SNARE proteins, required for vacuolar biogenesis
Visualize the interactome of PEP3
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Endosome 0.606 0.221 0.749
Mito 0.268 0.494 0.234
Nucleolus 0.429 0.286 0.230
SpindlePole 0.096 NaN 0.219
Vac/Vac Memb 0.288 0.318 0.103
Nuc Periphery NaN 0.104 NaN
Peroxisome NaN NaN 0.159

GFP localization & abundance

GFP localization GFP abundance
endosome 2020

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
PEP3 0 0 0 0 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
VPS41 YDR080W Subunit of the HOPS endocytic tethering complex physical 16 4 10 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Two-hybrid, Affinity Capture-Western, Two-hybrid, Affinity Capture-Western, Affinity Capture-Western, Co-purification, Affinity Capture-Western, Affinity Capture-Western
PEP5 YMR231W Histone E3 ligase, component of CORVET membrane tethering complex physical 16 5 8 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Two-hybrid, Affinity Capture-MS, Affinity Capture-MS, Reconstituted Complex, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western, Co-purification
VPS33 YLR396C ATP-binding protein that is a subunit of the HOPS and CORVET complexes physical 14 5 10 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Co-purification, Affinity Capture-MS, Reconstituted Complex, Affinity Capture-Western, Two-hybrid, Two-hybrid, Affinity Capture-Western, Co-purification
VAM6 YDL077C Guanine nucleotide exchange factor for the GTPase Gtr1p physical 11 4 8 Affinity Capture-Western, Affinity Capture-Western, Co-purification, Two-hybrid, Affinity Capture-Western, Two-hybrid, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Co-purification, Affinity Capture-MS
VPS8 YAL002W Membrane-binding component of the CORVET complex physical 11 4 6 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Two-hybrid, Two-hybrid, Affinity Capture-Western, Two-hybrid, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex
VPS16 YPL045W Subunit of the HOPS and the CORVET complexes physical 7 3 4 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Co-purification
VAM7 YGL212W Vacuolar SNARE protein physical 6 3 5 Affinity Capture-Western, Co-purification, Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex
VAM3 YOR106W Syntaxin-like vacuolar t-SNARE physical 6 3 4 Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western, Co-fractionation, Affinity Capture-Western, Reconstituted Complex
VPS3 YDR495C Component of CORVET membrane tethering complex physical 5 3 5 Affinity Capture-MS, Two-hybrid, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western
TOR1 YJR066W PIK-related protein kinase and rapamycin target genetic 4 3 3 Synthetic Lethality, Synthetic Growth Defect, Phenotypic Suppression, Synthetic Lethality
VAM3 YOR106W Syntaxin-like vacuolar t-SNARE genetic 2 2 2 Dosage Rescue, Phenotypic Enhancement
PEP7 YDR323C Adaptor protein involved in vesicle-mediated vacuolar protein sorting physical 2 2 2 Affinity Capture-Western, Two-hybrid
PEP3 YLR148W Component of CORVET membrane tethering complex physical 2 2 2 Two-hybrid, Co-crystal Structure
VMA1 YDL185W Subunit A of the V1 peripheral membrane domain of V-ATPase genetic 2 2 2 Synthetic Growth Defect, Phenotypic Suppression
AAP1 YHR047C Arginine/alanine amino peptidase physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
PEP7 YDR323C Adaptor protein involved in vesicle-mediated vacuolar protein sorting genetic 2 1 2 Phenotypic Enhancement, Phenotypic Enhancement
GTR2 YGR163W Subunit of a TORC1-stimulating GTPase and the EGO/GSE complex genetic 2 2 1 Phenotypic Enhancement, Phenotypic Suppression
GTR1 YML121W Subunit of a TORC1-stimulating GTPase and the EGO/GSE complex genetic 2 2 1 Phenotypic Enhancement, Phenotypic Suppression
ARP4 YJL081C Nuclear actin-related protein involved in chromatin remodeling genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
ESA1 YOR244W Catalytic subunit of the histone acetyltransferase complex (NuA4) genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
EAF1 YDR359C Component of the NuA4 histone acetyltransferase complex genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
EPL1 YFL024C Subunit of NuA4, an essential histone H4/H2A acetyltransferase complex genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
YAF9 YNL107W Subunit of NuA4 histone H4 acetyltransferase and SWR1 complexes genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
YNG2 YHR090C Subunit of NuA4, an essential histone acetyltransferase complex genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
TAF9 YMR236W Subunit (17 kDa) of TFIID and SAGA complexes genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
MCM2 YBL023C Protein involved in DNA replication genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
CDC20 YGL116W Activator of anaphase-promoting complex/cyclosome (APC/C) genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
FKH1 YIL131C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SPT10 YJL127C Histone H3 acetylase with a role in transcriptional regulation regulation 1 1 1 DNA to cDNA expression microarray evidence
YAP6 YDR259C Basic leucine zipper (bZIP) transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
TFC7 YOR110W RNA pol III transcription initiation factor complex (TFIIIC) subunit regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MED4 YOR174W Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
ECM22 YLR228C Sterol regulatory element binding protein regulation 1 1 1 DNA to cDNA expression microarray evidence
BRE1 YDL074C E3 ubiquitin ligase genetic 1 1 1 Synthetic Growth Defect
ARL1 YBR164C Soluble GTPase with a role in regulation of membrane traffic genetic 1 1 1 Negative Genetic
ACT1 YFL039C Actin, structural protein in cytoskeleton genetic 1 1 1 Synthetic Haploinsufficiency
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-RNA
APL5 YPL195W Delta adaptin-like subunit of the clathrin associated protein complex physical 1 1 1 Reconstituted Complex
ARD1 YHR013C Subunit of protein N-terminal acetyltransferase NatA genetic 1 1 1 Synthetic Growth Defect
ASF1 YJL115W Nucleosome assembly factor genetic 1 1 1 Synthetic Growth Defect
EDE1 YBL047C Scaffold protein involved in the formation of early endocytic sites genetic 1 1 1 Phenotypic Enhancement
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
ISW1 YBR245C ATPase subunit of imitation-switch (ISWI) class chromatin remodelers physical 1 1 1 Affinity Capture-RNA
VPS16 YPL045W Subunit of the HOPS and the CORVET complexes genetic 1 1 1 Dosage Rescue
SEC7 YDR170C Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors physical 1 1 1 Affinity Capture-MS
PTC1 YDL006W Type 2C protein phosphatase (PP2C) physical 1 1 1 Affinity Capture-MS
YPT7 YML001W Rab family GTPase physical 1 1 1 Affinity Capture-Western
SML1 YML058W Ribonucleotide reductase inhibitor physical 1 1 1 Affinity Capture-MS
PRO2 YOR323C Gamma-glutamyl phosphate reductase physical 1 1 1 Affinity Capture-MS
TLG2 YOL018C Syntaxin-like t-SNARE physical 1 1 1 Co-purification
VTI1 YMR197C Protein involved in cis-Golgi membrane traffic physical 1 1 1 Affinity Capture-Western
YPT52 YKR014C Endosomal Rab family GTPase physical 1 1 1 Two-hybrid
SPT21 YMR179W Protein with a role in transcriptional silencing physical 1 1 1 Affinity Capture-MS
VPS30 YPL120W Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II physical 1 1 1 Affinity Capture-MS
VPS34 YLR240W Phosphatidylinositol (PI) 3-kinase that synthesizes PI-3-phosphate physical 1 1 1 Affinity Capture-MS
YCK3 YER123W Palmitoylated vacuolar membrane-localized casein kinase I isoform physical 1 1 1 Biochemical Activity
WSS1 YHR134W SUMO-ligase and SUMO-targeted metalloprotease physical 1 1 1 Affinity Capture-MS
SCP160 YJL080C Essential RNA-binding G protein effector of mating response pathway physical 1 1 1 Affinity Capture-MS
TMA46 YOR091W Protein of unknown function that associates with translating ribosomes physical 1 1 1 Affinity Capture-MS
SLT2 YHR030C Serine/threonine MAP kinase physical 1 1 1 PCA
SEC61 YLR378C Conserved ER protein translocation channel physical 1 1 1 Affinity Capture-MS
VPS21 YOR089C Endosomal Rab family GTPase genetic 1 1 1 Phenotypic Enhancement
VPS45 YGL095C Protein of the Sec1p/Munc-18 family genetic 1 1 1 Phenotypic Enhancement
SLA2 YNL243W Adaptor protein that links actin to clathrin and endocytosis genetic 1 1 1 Synthetic Lethality
YPP1 YGR198W Cargo-transport protein involved in endocytosis genetic 1 1 1 Phenotypic Enhancement
TSA1 YML028W Thioredoxin peroxidase genetic 1 1 1 Synthetic Growth Defect
POL32 YJR043C Third subunit of DNA polymerase delta genetic 1 1 1 Synthetic Growth Defect
RTT101 YJL047C Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex genetic 1 1 1 Synthetic Growth Defect
RAD27 YKL113C 5' to 3' exonuclease, 5' flap endonuclease genetic 1 1 1 Synthetic Growth Defect
RPN10 YHR200W Proteasome polyubiquitin receptor genetic 1 1 1 Synthetic Growth Defect
RTT107 YHR154W BRCA1 C-terminal domain protein needed for recovery from DNA damage genetic 1 1 1 Synthetic Growth Defect
RAD53 YPL153C DNA damage response kinase genetic 1 1 1 Synthetic Lethality
RAD6 YGL058W Ubiquitin-conjugating enzyme (E2) genetic 1 1 1 Synthetic Growth Defect
PMA2 YPL036W Plasma membrane H+-ATPase genetic 1 1 1 Negative Genetic
SCH9 YHR205W AGC family protein kinase genetic 1 1 1 Phenotypic Suppression
VPH2 YKL119C Integral membrane protein required for V-ATPase function genetic 1 1 1 Phenotypic Suppression
YPT6 YLR262C Rab family GTPase genetic 1 1 1 Dosage Rescue
NAT1 YDL040C Subunit of protein N-terminal acetyltransferase NatA genetic 1 1 1 Synthetic Growth Defect
CAF20 YOR276W Phosphoprotein of the mRNA cap-binding complex physical 1 1 1 Affinity Capture-RNA
GET1 YGL020C Subunit of the GET complex genetic 1 1 1 Synthetic Growth Defect
GET2 YER083C Subunit of the GET complex genetic 1 1 1 Synthetic Growth Defect
ISU1 YPL135W Conserved protein of the mitochondrial matrix genetic 1 1 1 Negative Genetic
DIA2 YOR080W Origin-binding F-box protein genetic 1 1 1 Synthetic Lethality
PAP2 YOL115W Non-canonical poly(A) polymerase genetic 1 1 1 Synthetic Growth Defect
MMS22 YLR320W Subunit of E3 ubiquitin ligase complex involved in replication repair genetic 1 1 1 Synthetic Lethality
PEP12 YOR036W Target membrane receptor (t-SNARE) genetic 1 1 1 Phenotypic Enhancement
CSE4 YKL049C Centromeric histone H3-like protein genetic 1 1 1 Synthetic Growth Defect
MON1 YGL124C Subunit of a heterodimeric guanine nucleotide exchange factor (GEF) physical 1 1 1 Two-hybrid
AUR1 YKL004W Phosphatidylinositol:ceramide phosphoinositol transferase genetic 1 1 1 Negative Genetic
LYS21 YDL131W Homocitrate synthase isozyme genetic 1 1 1 Negative Genetic
LGE1 YPL055C Protein involved in histone H2B ubiquitination genetic 1 1 1 Synthetic Growth Defect
CDC1 YDR182W Putative mannose-ethanolamine phosphate phosphodiesterase genetic 1 1 1 Synthetic Rescue