Standard name Systematic name Name description Description
EDE1 YBL047C Scaffold protein involved in the formation of early endocytic sites Scaffold protein involved in the formation of early endocytic sites; putative regulator of cytokinesis; homo-oligomerization is required for localization to and organization of endocytic sites; functions in autophagy of aberrant clathrin-mediated endocytosis (CME) protein condensates; binds membranes in a ubiquitin-dependent manner; interacts with Cmk2 and functions upstream of CMK2 in regulating non-apoptotic cell death; homolog of mammalian Eps15
Visualize the interactome of EDE1
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Bud 0.103 0.175 0.218
Cell Periphery 0.220 0.291 0.228
Cort. Patches 0.520 0.679 0.731
ER 0.087 0.134 0.061
Golgi 0.443 0.119 0.081
Mito 0.120 0.071 0.249
Cytoplasm NaN 0.060 0.081
Peroxisome NaN NaN 0.061

GFP localization & abundance

GFP localization GFP abundance
punctate composite 1380

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
EDE1 0 0 1 1 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
SYP1 YCR030C Negative regulator of WASP-Arp23 complex physical 10 5 7 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Two-hybrid, Two-hybrid, Reconstituted Complex, Co-localization, Affinity Capture-Western, Affinity Capture-MS
SLT2 YHR030C Serine/threonine MAP kinase genetic 8 3 5 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Dosage Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic
UBI4 YLL039C Ubiquitin physical 7 3 6 Co-crystal Structure, Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Affinity Capture-Western
CLA4 YNL298W Cdc42p-activated signal transducing kinase genetic 6 2 6 Synthetic Lethality, Negative Genetic, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic
FKS1 YLR342W Catalytic subunit of 1,3-beta-D-glucan synthase genetic 6 2 4 Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Lethality, Negative Genetic, Negative Genetic
CHS5 YLR330W Component of the exomer complex genetic 6 2 4 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic
BCK1 YJL095W MAPKKK acting in the protein kinase C signaling pathway genetic 6 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
HRR25 YPL204W Conserved casein kinase, monopolin subunit physical 5 3 4 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity, Affinity Capture-MS
CCW12 YLR110C Cell wall mannoprotein genetic 5 3 4 Negative Genetic, Phenotypic Suppression, Phenotypic Suppression, Synthetic Growth Defect, Negative Genetic
ENT2 YLR206W Epsin-like protein required for endocytosis and actin patch assembly genetic 5 2 4 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
RUD3 YOR216C Golgi matrix protein genetic 5 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
HOC1 YJR075W Alpha-1,6-mannosyltransferase genetic 5 2 3 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic
ABP1 YCR088W Actin-binding protein of the cortical actin cytoskeleton genetic 5 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
ATG8 YBL078C Ub-like protein physical 5 5 1 Co-crystal Structure, Affinity Capture-MS, Affinity Capture-Western, Co-localization, Reconstituted Complex
EDE1 YBL047C Scaffold protein involved in the formation of early endocytic sites physical 4 3 4 Two-hybrid, Reconstituted Complex, Two-hybrid, Affinity Capture-Western
BNI4 YNL233W Targeting subunit for Glc7p protein phosphatase genetic 4 2 4 Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
CHS7 YHR142W Protein of unknown function genetic 4 2 4 Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic
PHO23 YNL097C Component of the Rpd3L histone deacetylase complex genetic 4 2 3 Positive Genetic, Positive Genetic, Positive Genetic, Phenotypic Enhancement
PBS2 YJL128C MAP kinase kinase of the HOG signaling pathway genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
ILM1 YJR118C Protein of unknown function genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
BRE5 YNR051C Ubiquitin protease cofactor genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
CHS6 YJL099W Member of the ChAPs (Chs5p-Arf1p-binding proteins) family genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
END3 YNL084C EH domain-containing protein involved in endocytosis genetic 4 3 2 Synthetic Lethality, Synthetic Lethality, Phenotypic Suppression, Phenotypic Enhancement
HUR1 YGL168W Protein with a role in DNA repair genetic 4 1 2 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
PAN1 YIR006C Part of actin cytoskeleton-regulatory complex Pan1p-Sla1p-End3p genetic 3 3 3 Synthetic Lethality, Phenotypic Enhancement, Negative Genetic
PAL1 YDR348C Protein of unknown function thought to be involved in endocytosis physical 3 2 3 Affinity Capture-MS, Affinity Capture-MS, Reconstituted Complex
MDM35 YKL053C-A Mitochondrial intermembrane space protein genetic 3 2 3 Negative Genetic, Negative Genetic, Phenotypic Enhancement
ORM2 YLR350W Protein that mediates sphingolipid homeostasis genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
PBR1 YNL181W Putative oxidoreductase genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
BCY1 YIL033C Regulatory subunit of the cyclic AMP-dependent protein kinase (PKA) genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
INN1 YNL152W Essential protein that associates with contractile actomyosin ring genetic 3 3 2 Negative Genetic, Synthetic Growth Defect, Phenotypic Enhancement
CDC13 YDL220C Single stranded DNA-binding protein found at TG1-3 telomere G-tails genetic 3 3 2 Synthetic Rescue, Synthetic Growth Defect, Positive Genetic
VAM7 YGL212W Vacuolar SNARE protein genetic 3 2 2 Negative Genetic, Negative Genetic, Phenotypic Enhancement
SEC66 YBR171W Non-essential subunit of Sec63 complex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
EMI1 YDR512C Non-essential protein of unknown function genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
PMR1 YGL167C High affinity Ca2+/Mn2+ P-type ATPase genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
SMI1 YGR229C Protein involved in the regulation of cell wall synthesis genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
MNN11 YJL183W Subunit of a Golgi mannosyltransferase complex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
PGM1 YKL127W Phosphoglucomutase, minor isoform genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
MET14 YKL001C Adenylylsulfate kinase genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
UTH1 YKR042W Mitochondrial inner membrane protein genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
MSS1 YMR023C Mitochondrial protein genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
MOT3 YMR070W Transcriptional repressor, activator genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
RGL1 YPL066W Regulator of Rho1p signaling, cofactor of Tus1p genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
THP3 YPR045C Protein that may have a role in transcription elongation genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
ECM33 YBR078W GPI-anchored protein involved in efficient glucose uptake genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
CYK3 YDL117W SH3-domain protein located in the bud neck and cytokinetic actin ring genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
BNI1 YNL271C Formin physical 2 2 2 Reconstituted Complex, PCA
RSP5 YER125W NEDD4 family E3 ubiquitin ligase genetic 2 2 2 Synthetic Lethality, Negative Genetic
IES2 YNL215W Protein that associates with the INO80 chromatin remodeling complex genetic 2 2 2 Negative Genetic, Phenotypic Enhancement
VPS27 YNR006W Endosomal protein that forms a complex with Hse1p genetic 2 2 2 Negative Genetic, Phenotypic Enhancement
IRA2 YOL081W GTPase-activating protein genetic 2 2 2 Negative Genetic, Phenotypic Enhancement
TFB5 YDR079C-A Component of RNA polymerase II general transcription factor TFIIH genetic 2 2 2 Negative Genetic, Phenotypic Enhancement
ARP8 YOR141C Nuclear actin-related protein involved in chromatin remodeling genetic 2 2 2 Negative Genetic, Phenotypic Enhancement
AKL1 YBR059C Ser/Thr protein kinase physical 2 2 2 Biochemical Activity, Affinity Capture-MS
CAP1 YKL007W Alpha subunit of the capping protein heterodimer (Cap1p and Cap2p) genetic 2 1 2 Negative Genetic, Negative Genetic
CDC11 YJR076C Component of the septin ring that is required for cytokinesis genetic 2 1 2 Negative Genetic, Negative Genetic
SLA2 YNL243W Adaptor protein that links actin to clathrin and endocytosis physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
PSH1 YOL054W E3 ubiquitin ligase targeting centromere-binding protein Cse4p physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
YAP1802 YGR241C Protein of the AP180 family, involved in clathrin cage assembly physical 2 1 2 Two-hybrid, Two-hybrid
SGM1 YJR134C Protein of unknown function physical 2 1 2 Two-hybrid, Two-hybrid
SIF2 YBR103W WD40 repeat-containing subunit of Set3C histone deacetylase complex genetic 2 1 2 Negative Genetic, Negative Genetic
KAR4 YCL055W Transcription factor required for response to pheromones genetic 2 1 2 Negative Genetic, Negative Genetic
SLM3 YDL033C tRNA-specific 2-thiouridylase genetic 2 1 2 Negative Genetic, Negative Genetic
MNN10 YDR245W Subunit of a Golgi mannosyltransferase complex genetic 2 1 2 Negative Genetic, Negative Genetic
TCD2 YKL027W tRNA threonylcarbamoyladenosine dehydratase genetic 2 1 2 Negative Genetic, Negative Genetic
ELO3 YLR372W Elongase genetic 2 1 2 Negative Genetic, Negative Genetic
SUB1 YMR039C Transcriptional regulator genetic 2 1 2 Negative Genetic, Negative Genetic
FLC1 YPL221W Flavin adenine dinucleotide transporter genetic 2 1 2 Negative Genetic, Negative Genetic
MCM10 YIL150C Essential chromatin-associated protein genetic 2 1 2 Negative Genetic, Negative Genetic
SKT5 YBL061C Activator of Chs3p (chitin synthase III) during vegetative growth genetic 2 1 2 Synthetic Growth Defect, Synthetic Growth Defect
TPM1 YNL079C Major isoform of tropomyosin genetic 2 1 2 Negative Genetic, Negative Genetic
SAC1 YKL212W Phosphatidylinositol phosphate phosphatase genetic 2 1 2 Negative Genetic, Negative Genetic
RPL40B YKR094C Ubiquitin-ribosomal 60S subunit protein L40B fusion protein genetic 2 1 2 Negative Genetic, Negative Genetic
RIC1 YLR039C Protein involved in retrograde transport to the cis-Golgi network genetic 2 1 2 Positive Genetic, Positive Genetic
MOG1 YJR074W Conserved nuclear protein that interacts with GTP-Gsp1p genetic 2 1 2 Negative Genetic, Negative Genetic
ANP1 YEL036C Subunit of the alpha-1,6 mannosyltransferase complex genetic 2 1 2 Negative Genetic, Negative Genetic
CNB1 YKL190W Calcineurin B genetic 2 1 2 Negative Genetic, Negative Genetic
CDC43 YGL155W Beta subunit of geranylgeranyltransferase type I genetic 2 1 2 Negative Genetic, Negative Genetic
CLC1 YGR167W Clathrin light chain genetic 2 1 2 Negative Genetic, Negative Genetic
CHS3 YBR023C Chitin synthase III genetic 2 1 2 Synthetic Growth Defect, Synthetic Growth Defect
AKR1 YDR264C Palmitoyl transferase involved in protein palmitoylation genetic 2 1 2 Negative Genetic, Negative Genetic
CAP2 YIL034C Beta subunit of the capping protein heterodimer (Cap1p and Cap2p) genetic 2 1 2 Negative Genetic, Negative Genetic
ARV1 YLR242C Cortical ER protein genetic 2 1 2 Positive Genetic, Positive Genetic
HRR25 YPL204W Conserved casein kinase, monopolin subunit genetic 2 2 1 Synthetic Growth Defect, Phenotypic Enhancement
ENT1 YDL161W Epsin-like protein involved in endocytosis and actin patch assembly physical 2 2 1 Two-hybrid, Reconstituted Complex
SPS2 YDR522C Protein expressed during sporulation genetic 2 1 1 Negative Genetic, Negative Genetic
RPS16A YMR143W Protein component of the small (40S) ribosomal subunit genetic 2 1 1 Negative Genetic, Negative Genetic
HLJ1 YMR161W Co-chaperone for Hsp40p genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
SKY1 YMR216C SR protein kinase (SRPK) genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
GLO3 YER122C ADP-ribosylation factor GTPase activating protein (ARF GAP) genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
RER1 YCL001W Protein involved in retention of membrane proteins genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
KEX2 YNL238W Kexin, a subtilisin-like protease (proprotein convertase) genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
ROT2 YBR229C Glucosidase II catalytic subunit genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
MSC1 YML128C Protein of unknown function genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
EMP65 YER140W Integral membrane protein of the ER genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
SSO2 YMR183C Plasma membrane t-SNARE genetic 2 1 1 Positive Genetic, Positive Genetic
CNE1 YAL058W Calnexin genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
APQ12 YIL040W Nuclear envelope/ER integral membrane protein genetic 2 1 1 Negative Genetic, Negative Genetic
XBP1 YIL101C Transcriptional repressor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
REB1 YBR049C RNA polymerase I enhancer binding protein regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit regulation 1 1 1 quantitative mass spectrometry evidence
SUA7 YPR086W Transcription factor TFIIB regulation 1 1 1 chromatin immunoprecipitation-chip evidence
AXL2 YIL140W Integral plasma membrane protein genetic 1 1 1 Negative Genetic
DED1 YOR204W ATP-dependent DEAD-box RNA helicase with strand-annealing activity genetic 1 1 1 Negative Genetic
ACT1 YFL039C Actin, structural protein in cytoskeleton genetic 1 1 1 Positive Genetic
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
ECM16 YMR128W Essential DEAH-box ATP-dependent RNA helicase specific to U3 snoRNP physical 1 1 1 Affinity Capture-MS
ATG14 YBR128C Autophagy-specific subunit of phosphatidylinositol 3-kinase complex I genetic 1 1 1 Phenotypic Enhancement
APL1 YJR005W Beta-adaptin physical 1 1 1 Affinity Capture-MS
ARC15 YIL062C Subunit of the ARP2/3 complex genetic 1 1 1 Positive Genetic
ARP2 YDL029W Essential component of the Arp2/3 complex genetic 1 1 1 Positive Genetic
CDC10 YCR002C Component of the septin ring, required for cytokinesis genetic 1 1 1 Negative Genetic
CDC12 YHR107C Component of the septin ring that is required for cytokinesis genetic 1 1 1 Negative Genetic
CHC1 YGL206C Clathrin heavy chain genetic 1 1 1 Negative Genetic
CKS1 YBR135W Cyclin-dependent protein kinase regulatory subunit and adaptor genetic 1 1 1 Negative Genetic
COX4 YGL187C Subunit IV of cytochrome c oxidase genetic 1 1 1 Negative Genetic
SYP1 YCR030C Negative regulator of WASP-Arp23 complex genetic 1 1 1 Phenotypic Suppression
RAD53 YPL153C DNA damage response kinase physical 1 1 1 Affinity Capture-MS
NUP42 YDR192C FG-nucleoporin component of central core of the nuclear pore complex physical 1 1 1 Affinity Capture-MS
ENT1 YDL161W Epsin-like protein involved in endocytosis and actin patch assembly genetic 1 1 1 Phenotypic Enhancement
NAF1 YNL124W RNA-binding protein required for the assembly of box H/ACA snoRNPs physical 1 1 1 Affinity Capture-MS
RPA34 YJL148W RNA polymerase I subunit A34.5 physical 1 1 1 Affinity Capture-MS
RPL2A YFR031C-A Ribosomal 60S subunit protein L2A physical 1 1 1 Affinity Capture-MS
SWE1 YJL187C Protein kinase that regulates the G2/M transition physical 1 1 1 Biochemical Activity
YCK1 YHR135C Palmitoylated plasma membrane-bound casein kinase I (CK1) isoform physical 1 1 1 Biochemical Activity
FRK1 YPL141C Protein kinase of unknown cellular role physical 1 1 1 Biochemical Activity
HEK2 YBL032W RNA binding protein involved in asymmetric localization of ASH1 mRNA physical 1 1 1 Affinity Capture-RNA
ESA1 YOR244W Catalytic subunit of the histone acetyltransferase complex (NuA4) physical 1 1 1 Biochemical Activity
SLA1 YBL007C Cytoskeletal protein binding protein physical 1 1 1 Two-hybrid
SLA1 YBL007C Cytoskeletal protein binding protein genetic 1 1 1 Negative Genetic
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-RNA
PRK1 YIL095W Ser/Thr protein kinase physical 1 1 1 Biochemical Activity
RPN11 YFR004W Metalloprotease subunit of 19S regulatory particle physical 1 1 1 Affinity Capture-MS
PKC1 YBL105C Protein serine/threonine kinase physical 1 1 1 Affinity Capture-MS
PHO85 YPL031C Cyclin-dependent kinase physical 1 1 1 Biochemical Activity
PXA1 YPL147W Subunit of heterodimeric peroxisomal ABC transport complex, with Pxa2p physical 1 1 1 Affinity Capture-Western
SPC72 YAL047C Gamma-tubulin small complex (gamma-TuSC) receptor physical 1 1 1 Two-hybrid
GTA1 YEL043W Protein of unknown function physical 1 1 1 Two-hybrid
RSC8 YFR037C Component of the RSC chromatin remodeling complex physical 1 1 1 Two-hybrid
SEC9 YGR009C t-SNARE protein required for secretory vesicle-plasma membrane fusion physical 1 1 1 Two-hybrid
SPR3 YGR059W Sporulation-specific homolog of the CDC3/10/11/12 family of genes physical 1 1 1 Two-hybrid
ETP1 YHL010C Protein of unknown function required for growth on ethanol physical 1 1 1 Two-hybrid
END3 YNL084C EH domain-containing protein involved in endocytosis physical 1 1 1 Two-hybrid
SBP1 YHL034C Protein that binds eIF4G and has a role in repression of translation physical 1 1 1 Affinity Capture-RNA
SFP1 YLR403W Regulates transcription of ribosomal protein and biogenesis genes physical 1 1 1 Co-localization
MLP1 YKR095W Myosin-like protein associated with the nuclear envelope physical 1 1 1 Affinity Capture-MS
TOM1 YDR457W E3 ubiquitin ligase of the hect-domain class physical 1 1 1 Affinity Capture-MS
ISW1 YBR245C ATPase subunit of imitation-switch (ISWI) class chromatin remodelers physical 1 1 1 Affinity Capture-RNA
SAM50 YNL026W Component of the Sorting and Assembly Machinery (SAM) complex physical 1 1 1 Affinity Capture-MS
PUF4 YGL014W Member of the PUF protein family physical 1 1 1 Affinity Capture-RNA
MPT5 YGL178W mRNA-binding protein of the PUF family physical 1 1 1 Affinity Capture-RNA
UTP10 YJL109C Nucleolar protein physical 1 1 1 Affinity Capture-MS
RIM21 YNL294C pH sensor molecule, component of the RIM101 pathway physical 1 1 1 Reconstituted Complex
RIM21 YNL294C pH sensor molecule, component of the RIM101 pathway genetic 1 1 1 Negative Genetic
SIS1 YNL007C Type II HSP40 co-chaperone that interacts with the HSP70 protein Ssa1p physical 1 1 1 Affinity Capture-MS
TSA1 YML028W Thioredoxin peroxidase physical 1 1 1 Affinity Capture-MS
ORC6 YHR118C Subunit of the origin recognition complex (ORC) genetic 1 1 1 Synthetic Lethality
HSP82 YPL240C Hsp90 chaperone genetic 1 1 1 Synthetic Growth Defect
HSC82 YMR186W Cytoplasmic chaperone of the Hsp90 family genetic 1 1 1 Synthetic Growth Defect
LYS20 YDL182W Homocitrate synthase isozyme and functions in DNA repair genetic 1 1 1 Negative Genetic
YCK2 YNL154C Palmitoylated plasma membrane-bound casein kinase I (CK1) isoform genetic 1 1 1 Negative Genetic
MKS1 YNL076W Pleiotropic negative transcriptional regulator genetic 1 1 1 Negative Genetic
YOR131C YOR131C Putative haloacid dehalogenase-like hydrolase genetic 1 1 1 Negative Genetic
OST2 YOR103C Epsilon subunit of the oligosaccharyltransferase complex genetic 1 1 1 Negative Genetic
SCD5 YOR329C Protein required for normal actin organization and endocytosis genetic 1 1 1 Negative Genetic
KAR2 YJL034W ATPase involved in protein import into the ER genetic 1 1 1 Positive Genetic
GUP1 YGL084C Plasma membrane protein involved in remodeling GPI anchors genetic 1 1 1 Negative Genetic
RGD1 YBR260C GTPase-activating protein (RhoGAP) for Rho3p and Rho4p genetic 1 1 1 Negative Genetic
HKR1 YDR420W Mucin family member that functions as an osmosensor in the HOG pathway genetic 1 1 1 Negative Genetic
FAB1 YFR019W 1-phosphatidylinositol-3-phosphate 5-kinase genetic 1 1 1 Negative Genetic
GIM4 YEL003W Subunit of the heterohexameric cochaperone prefoldin complex genetic 1 1 1 Negative Genetic
WHI2 YOR043W Negative regulator of TORC1 in response to limiting leucine genetic 1 1 1 Negative Genetic
ELM1 YKL048C Serine/threonine protein kinase genetic 1 1 1 Negative Genetic
PEP12 YOR036W Target membrane receptor (t-SNARE) genetic 1 1 1 Negative Genetic
SRS2 YJL092W DNA helicase and DNA-dependent ATPase genetic 1 1 1 Dosage Lethality
VPH2 YKL119C Integral membrane protein required for V-ATPase function genetic 1 1 1 Negative Genetic
YPT6 YLR262C Rab family GTPase genetic 1 1 1 Positive Genetic
GIM5 YML094W Subunit of the heterohexameric cochaperone prefoldin complex genetic 1 1 1 Negative Genetic
HER2 YMR293C Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex genetic 1 1 1 Positive Genetic
MDM32 YOR147W Mitochondrial inner membrane protein with similarity to Mdm31p genetic 1 1 1 Negative Genetic
VMA11 YPL234C Vacuolar ATPase V0 domain subunit c' genetic 1 1 1 Negative Genetic
YME1 YPR024W Catalytic subunit of i-AAA protease complex genetic 1 1 1 Positive Genetic
NPL3 YDR432W RNA-binding protein genetic 1 1 1 Synthetic Growth Defect
YKU70 YMR284W Subunit of the telomeric Ku complex (Yku70p-Yku80p) genetic 1 1 1 Negative Genetic
TAF1 YGR274C TFIID subunit, involved in RNA pol II transcription initiation genetic 1 1 1 Synthetic Lethality
GIN4 YDR507C Protein kinase involved in bud growth and assembly of the septin ring genetic 1 1 1 Dosage Growth Defect
HOG1 YLR113W Mitogen-activated protein kinase involved in osmoregulation genetic 1 1 1 Dosage Growth Defect
TPK3 YKL166C cAMP-dependent protein kinase catalytic subunit genetic 1 1 1 Phenotypic Suppression
SEC1 YDR164C Sm-like protein involved in docking and fusion of exocytic vesicles genetic 1 1 1 Positive Genetic
GCD11 YER025W Gamma subunit of the translation initiation factor eIF2 genetic 1 1 1 Positive Genetic
GWT1 YJL091C Protein involved in the inositol acylation of GlcN-PI genetic 1 1 1 Positive Genetic
GPI2 YPL076W Protein involved in the synthesis of GlcNAc-PI genetic 1 1 1 Positive Genetic
VPS51 YKR020W Component of the GARP (Golgi-associated retrograde protein) complex genetic 1 1 1 Positive Genetic
ERG6 YML008C Delta(24)-sterol C-methyltransferase genetic 1 1 1 Positive Genetic
MDM34 YGL219C Mitochondrial component of the ERMES complex genetic 1 1 1 Positive Genetic
MMM1 YLL006W ER integral membrane protein, ERMES complex subunit genetic 1 1 1 Positive Genetic
RSO55 YLR281C Mitochondrial protein of unknown function genetic 1 1 1 Positive Genetic
ROM2 YLR371W Guanine nucleotide exchange factor (GEF) for Rho1p and Rho2p genetic 1 1 1 Positive Genetic
SLU7 YDR088C RNA splicing factor genetic 1 1 1 Negative Genetic
SUP35 YDR172W Translation termination factor eRF3 genetic 1 1 1 Negative Genetic
UTP7 YER082C Nucleolar protein genetic 1 1 1 Negative Genetic
PTI1 YGR156W Essential component of CPF (cleavage and polyadenylation factor) genetic 1 1 1 Negative Genetic
RPB3 YIL021W RNA polymerase II third largest subunit B44 genetic 1 1 1 Negative Genetic
UTP25 YIL091C Nucleolar protein genetic 1 1 1 Negative Genetic
PRP24 YMR268C Splicing factor that reanneals snRNPs during spliceosome recycling genetic 1 1 1 Negative Genetic
NPL4 YBR170C Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase genetic 1 1 1 Negative Genetic
ERD1 YDR414C Predicted membrane protein required for lumenal ER protein retention genetic 1 1 1 Negative Genetic
SNF1 YDR477W AMP-activated S/T protein kinase genetic 1 1 1 Negative Genetic
PCL6 YER059W Pho85p cyclin of the Pho80p subfamily genetic 1 1 1 Negative Genetic
PTH1 YHR189W One of two mitochondrially-localized peptidyl-tRNA hydrolases genetic 1 1 1 Negative Genetic
MDV1 YJL112W Peripheral protein of cytosolic face of mitochondrial outer membrane genetic 1 1 1 Negative Genetic
PAM17 YKR065C Constituent of the TIM23 complex genetic 1 1 1 Negative Genetic
PER33 YLR064W Protein that localizes to the endoplasmic reticulum genetic 1 1 1 Negative Genetic
SWI6 YLR182W Transcription cofactor genetic 1 1 1 Negative Genetic
YKE2 YLR200W Subunit of the heterohexameric Gim/prefoldin protein complex genetic 1 1 1 Negative Genetic
MMS22 YLR320W Subunit of E3 ubiquitin ligase complex involved in replication repair genetic 1 1 1 Negative Genetic
RTC1 YOL138C Subunit of SEACAT, a subcomplex of the SEA complex genetic 1 1 1 Negative Genetic
ODC2 YOR222W Mitochondrial inner membrane transporter genetic 1 1 1 Negative Genetic
RBL2 YOR265W Protein involved in microtubule morphogenesis genetic 1 1 1 Negative Genetic
TGS1 YPL157W Trimethyl guanosine synthase, conserved nucleolar methyl transferase genetic 1 1 1 Negative Genetic
RPL4B YDR012W Ribosomal 60S subunit protein L4B genetic 1 1 1 Negative Genetic
GIS1 YDR096W Histone demethylase and transcription factor genetic 1 1 1 Negative Genetic
RAD30 YDR419W DNA polymerase eta genetic 1 1 1 Negative Genetic
SSN2 YDR443C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
SOM1 YEL059C-A Subunit of the mitochondrial inner membrane peptidase (IMP) genetic 1 1 1 Negative Genetic
YER039C-A YER039C-A Putative protein of unknown function genetic 1 1 1 Negative Genetic
UBP6 YFR010W Ubiquitin-specific protease genetic 1 1 1 Negative Genetic
PHB2 YGR231C Subunit of the prohibitin complex (Phb1p-Phb2p) genetic 1 1 1 Negative Genetic
YHR045W YHR045W Putative protein of unknown function genetic 1 1 1 Negative Genetic
YHR050W-A YHR050W-A Protein of unknown function genetic 1 1 1 Negative Genetic
RPL34B YIL052C Ribosomal 60S subunit protein L34B genetic 1 1 1 Negative Genetic
EXG1 YLR300W Major exo-1,3-beta-glucanase of the cell wall genetic 1 1 1 Negative Genetic
YML053C YML053C Putative protein of unknown function genetic 1 1 1 Negative Genetic
SMA2 YML066C Meiosis-specific prospore membrane protein genetic 1 1 1 Negative Genetic
SEC4 YFL005W Rab family GTPase genetic 1 1 1 Phenotypic Suppression
VAN1 YML115C Component of the mannan polymerase I genetic 1 1 1 Negative Genetic
IMP2 YMR035W Catalytic subunit of mitochondrial inner membrane peptidase complex genetic 1 1 1 Negative Genetic
RPL16B YNL069C Ribosomal 60S subunit protein L16B genetic 1 1 1 Negative Genetic
MRPL10 YNL284C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
IFM1 YOL023W Mitochondrial translation initiation factor 2 genetic 1 1 1 Negative Genetic
MDM20 YOL076W Non-catalytic subunit of the NatB N-terminal acetyltransferase genetic 1 1 1 Negative Genetic
VPS28 YPL065W Component of the ESCRT-I complex genetic 1 1 1 Negative Genetic
HOF1 YMR032W F-BAR protein that regulates actin cytoskeleton organization genetic 1 1 1 Phenotypic Enhancement
YNG2 YHR090C Subunit of NuA4, an essential histone acetyltransferase complex genetic 1 1 1 Negative Genetic
MIH1 YMR036C Protein tyrosine phosphatase genetic 1 1 1 Negative Genetic
EMC3 YKL207W Member of conserved ER transmembrane complex genetic 1 1 1 Negative Genetic
NAP1 YKR048C Histone chaperone and assembly chaperone for Rps6a/b genetic 1 1 1 Negative Genetic
GPI19 YDR437W Subunit of GPI-GlcNAc transferase involved in synthesis of GlcNAc-PI genetic 1 1 1 Positive Genetic
TRS65 YGR166W Component of transport protein particle (TRAPP) complex II genetic 1 1 1 Negative Genetic
SGT1 YOR057W Cochaperone protein genetic 1 1 1 Positive Genetic
IES4 YOR189W Component of the INO80 chromatiin remodeling complex genetic 1 1 1 Negative Genetic
MTC1 YJL123C Protein of unknown function that may interact with ribosomes genetic 1 1 1 Negative Genetic
MDY2 YOL111C Protein involved in inserting tail-anchored proteins into ER membranes genetic 1 1 1 Negative Genetic
ILV1 YER086W Threonine deaminase, catalyzes first step in isoleucine biosynthesis genetic 1 1 1 Positive Genetic
ERG3 YLR056W C-5 sterol desaturase genetic 1 1 1 Positive Genetic
VAM6 YDL077C Guanine nucleotide exchange factor for the GTPase Gtr1p genetic 1 1 1 Phenotypic Enhancement
MRPS8 YMR158W Mitochondrial ribosomal protein of the small subunit genetic 1 1 1 Phenotypic Enhancement
YPT7 YML001W Rab family GTPase genetic 1 1 1 Phenotypic Enhancement
SNX4 YJL036W Sorting nexin genetic 1 1 1 Phenotypic Enhancement
VPS30 YPL120W Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II genetic 1 1 1 Phenotypic Enhancement
SIN3 YOL004W Component of both the Rpd3S and Rpd3L histone deacetylase complexes genetic 1 1 1 Phenotypic Enhancement
VAM3 YOR106W Syntaxin-like vacuolar t-SNARE genetic 1 1 1 Phenotypic Enhancement
VPS41 YDR080W Subunit of the HOPS endocytic tethering complex genetic 1 1 1 Phenotypic Enhancement
VAC8 YEL013W Vacuole-specific Myo2p receptor genetic 1 1 1 Phenotypic Enhancement
NSR1 YGR159C Nucleolin, nucleolar protein that binds nuclear localization sequences genetic 1 1 1 Phenotypic Enhancement
TRS85 YDR108W Component of transport protein particle (TRAPP) complex III genetic 1 1 1 Phenotypic Enhancement
RPS8A YBL072C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Phenotypic Enhancement
VPS1 YKR001C Dynamin-like GTPase required for vacuolar sorting genetic 1 1 1 Phenotypic Enhancement
SPT5 YML010W Spt4p/5p (DSIF) transcription elongation factor complex subunit genetic 1 1 1 Phenotypic Enhancement
SAP30 YMR263W Component of Rpd3L histone deacetylase complex genetic 1 1 1 Phenotypic Enhancement
SNF8 YPL002C Component of the ESCRT-II complex genetic 1 1 1 Phenotypic Enhancement
OPI3 YJR073C Methylene-fatty-acyl-phospholipid synthase genetic 1 1 1 Phenotypic Enhancement
VPS4 YPR173C AAA-ATPase involved in multivesicular body (MVB) protein sorting genetic 1 1 1 Phenotypic Enhancement
LSM1 YJL124C Lsm (Like Sm) protein genetic 1 1 1 Phenotypic Enhancement
PEP3 YLR148W Component of CORVET membrane tethering complex genetic 1 1 1 Phenotypic Enhancement
NPR2 YEL062W Subunit of the Iml1p/SEACIT complex genetic 1 1 1 Phenotypic Enhancement
UME1 YPL139C Component of both the Rpd3S and Rpd3L histone deacetylase complexes genetic 1 1 1 Phenotypic Enhancement
FUI1 YBL042C High affinity uridine permease, localizes to the plasma membrane genetic 1 1 1 Phenotypic Enhancement
TPS1 YBR126C Synthase subunit of trehalose-6-P synthase/phosphatase complex genetic 1 1 1 Phenotypic Enhancement
MRPS5 YBR251W Mitochondrial ribosomal protein of the small subunit genetic 1 1 1 Phenotypic Enhancement
STP22 YCL008C Component of the ESCRT-I complex genetic 1 1 1 Phenotypic Enhancement
SIT4 YDL047W Ceramide-activated, type 2A-related serine-threonine phosphatase genetic 1 1 1 Phenotypic Enhancement
KCS1 YDR017C Inositol hexakisphosphate and inositol heptakisphosphate kinase genetic 1 1 1 Phenotypic Enhancement
TPS2 YDR074W Phosphatase subunit of the trehalose-6-P synthase/phosphatase complex genetic 1 1 1 Phenotypic Enhancement
UME6 YDR207C Rpd3L histone deacetylase complex subunit genetic 1 1 1 Phenotypic Enhancement
HTA1 YDR225W Histone H2A genetic 1 1 1 Phenotypic Enhancement
SPT2 YER161C Protein involved in negative regulation of transcription genetic 1 1 1 Phenotypic Enhancement
MIG1 YGL035C Transcription factor involved in glucose repression genetic 1 1 1 Phenotypic Enhancement
RTF1 YGL244W Subunit of RNAPII-associated chromatin remodeling Paf1 complex genetic 1 1 1 Phenotypic Enhancement
UBR1 YGR184C E3 ubiquitin ligase (N-recognin) genetic 1 1 1 Phenotypic Enhancement
HSV2 YGR223C Phosphatidylinositol 3,5-bisphosphate-binding protein genetic 1 1 1 Phenotypic Enhancement
PFK1 YGR240C Alpha subunit of heterooctameric phosphofructokinase genetic 1 1 1 Phenotypic Enhancement
YTA7 YGR270W Chromatin-binding ATPase that regulates histone gene expression genetic 1 1 1 Phenotypic Enhancement
NPR3 YHL023C Subunit of the Iml1p/SEACIT complex genetic 1 1 1 Phenotypic Enhancement
NEM1 YHR004C Probable catalytic subunit of Nem1p-Spo7p phosphatase holoenzyme genetic 1 1 1 Phenotypic Enhancement
THR1 YHR025W Homoserine kinase genetic 1 1 1 Phenotypic Enhancement
KSP1 YHR082C Serine/threonine protein kinase genetic 1 1 1 Phenotypic Enhancement
LNP1 YHR192W Lunapark family member involved in ER network formation genetic 1 1 1 Phenotypic Enhancement
KGD1 YIL125W Subunit of the mitochondrial alpha-ketoglutarate dehydrogenase complex genetic 1 1 1 Phenotypic Enhancement
MSL1 YIR009W U2B component of U2 snRNP genetic 1 1 1 Phenotypic Enhancement
RSM22 YKL155C Mitochondrial ribosomal protein of the small subunit genetic 1 1 1 Phenotypic Enhancement
SRN2 YLR119W Component of the ESCRT-I complex genetic 1 1 1 Phenotypic Enhancement
TRM9 YML014W tRNA methyltransferase genetic 1 1 1 Phenotypic Enhancement
RPL6A YML073C Ribosomal 60S subunit protein L6A genetic 1 1 1 Phenotypic Enhancement
SPT21 YMR179W Protein with a role in transcriptional silencing genetic 1 1 1 Phenotypic Enhancement
RRG9 YNL213C Protein of unknown function genetic 1 1 1 Phenotypic Enhancement
SQS1 YNL224C Protein that stimulates the ATPase and helicase activities of Prp43p genetic 1 1 1 Phenotypic Enhancement
MSY1 YPL097W Mitochondrial tyrosyl-tRNA synthetase genetic 1 1 1 Phenotypic Enhancement
TCO89 YPL180W Subunit of TORC1 (Tor1p or Tor2p-Kog1p-Lst8p-Tco89p) genetic 1 1 1 Phenotypic Enhancement
USV1 YPL230W Putative transcription factor containing a C2H2 zinc finger genetic 1 1 1 Phenotypic Enhancement
MAK3 YPR051W Catalytic subunit of the NatC type N-terminal acetyltransferase (NAT) genetic 1 1 1 Phenotypic Enhancement
MED1 YPR070W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Phenotypic Enhancement
TOM5 YPR133W-A Component of the TOM (translocase of outer membrane) complex genetic 1 1 1 Phenotypic Enhancement
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
ECM29 YHL030W Scaffold protein physical 1 1 1 Affinity Capture-MS
CSE2 YNR010W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Phenotypic Enhancement
COG3 YER157W Essential component of the conserved oligomeric Golgi complex genetic 1 1 1 Negative Genetic
ATG3 YNR007C E2-like enzyme genetic 1 1 1 Phenotypic Enhancement
CMD1 YBR109C Calmodulin physical 1 1 1 Affinity Capture-MS
ATG18 YFR021W Phosphoinositide binding protein genetic 1 1 1 Phenotypic Enhancement
DOA4 YDR069C Ubiquitin hydrolase genetic 1 1 1 Negative Genetic
DEP1 YAL013W Component of the Rpd3L histone deacetylase complex genetic 1 1 1 Phenotypic Enhancement
CCT2 YIL142W Subunit beta of the cytosolic chaperonin Cct ring complex genetic 1 1 1 Negative Genetic
ATG9 YDL149W Transmembrane protein involved in forming Cvt and autophagic vesicles genetic 1 1 1 Phenotypic Enhancement
BRO1 YPL084W Cytoplasmic class E vacuolar protein sorting (VPS) factor genetic 1 1 1 Negative Genetic
ATG17 YLR423C Scaffold protein responsible for phagophore assembly site organization genetic 1 1 1 Phenotypic Enhancement
CMK1 YFR014C Calmodulin-dependent protein kinase physical 1 1 1 Biochemical Activity
CLN1 YMR199W G1 cyclin involved in regulation of the cell cycle genetic 1 1 1 Negative Genetic
ATG12 YBR217W Ubiquitin-like modifier involved in autophagy and the Cvt pathway genetic 1 1 1 Phenotypic Enhancement
ATG7 YHR171W Autophagy-related protein and dual specificity member of the E1 family genetic 1 1 1 Phenotypic Enhancement
ARE1 YCR048W Acyl-CoA:sterol acyltransferase physical 1 1 1 Two-hybrid
BEM4 YPL161C Protein involved in establishment of cell polarity and bud emergence genetic 1 1 1 Negative Genetic
ATG20 YDL113C Sorting nexin family member genetic 1 1 1 Phenotypic Enhancement
ATG4 YNL223W Conserved cysteine protease required for autophagy genetic 1 1 1 Phenotypic Enhancement
DUF1 YOL087C Ubiquitin-binding protein of unknown function physical 1 1 1 Affinity Capture-MS
CLN2 YPL256C G1 cyclin involved in regulation of the cell cycle genetic 1 1 1 Negative Genetic
ATG5 YPL149W Conserved protein involved in autophagy and the Cvt pathway genetic 1 1 1 Phenotypic Enhancement
ATP7 YKL016C Subunit d of the stator stalk of mitochondrial F1F0 ATP synthase genetic 1 1 1 Negative Genetic
DID4 YKL002W Class E Vps protein of the ESCRT-III complex genetic 1 1 1 Phenotypic Enhancement
ATG1 YGL180W Protein serine/threonine kinase genetic 1 1 1 Phenotypic Enhancement
ATG13 YPR185W Regulatory subunit of the Atg1p signaling complex genetic 1 1 1 Phenotypic Enhancement
ATG16 YMR159C Conserved protein involved in autophagy genetic 1 1 1 Phenotypic Enhancement
ASK10 YGR097W Regulator of the Fps1p glycerol channel genetic 1 1 1 Positive Genetic
CEP3 YMR168C Essential kinetochore protein genetic 1 1 1 Negative Genetic
BRF1 YGR246C TFIIIB B-related factor physical 1 1 1 Affinity Capture-MS
ATG23 YLR431C Peripheral membrane protein required for autophagy and CVT genetic 1 1 1 Phenotypic Enhancement
ATG8 YBL078C Ub-like protein genetic 1 1 1 Phenotypic Enhancement
BFR1 YOR198C Component of mRNP complexes associated with polyribosomes physical 1 1 1 Affinity Capture-RNA
CTK2 YJL006C Beta subunit of C-terminal domain kinase I (CTDK-I) genetic 1 1 1 Phenotypic Enhancement
CCZ1 YBR131W Subunit of a heterodimeric guanine nucleotide exchange factor (GEF) genetic 1 1 1 Phenotypic Enhancement
ATG2 YNL242W Peripheral membrane protein required for autophagic vesicle formation genetic 1 1 1 Phenotypic Enhancement
BUD6 YLR319C Actin- and formin-interacting protein physical 1 1 1 PCA
ATG10 YLL042C Conserved E2-like conjugating enzyme genetic 1 1 1 Phenotypic Enhancement
ARL3 YPL051W ARF-like small GTPase of the RAS superfamily genetic 1 1 1 Positive Genetic
EAF7 YNL136W Subunit of the NuA4 histone acetyltransferase complex genetic 1 1 1 Phenotypic Enhancement
AIM44 YPL158C Regulator of Cdc42p and Rho1p genetic 1 1 1 Negative Genetic
CFD1 YIL003W Highly conserved iron-sulfur cluster binding protein genetic 1 1 1 Negative Genetic
BPH1 YCR032W Protein homologous to Chediak-Higashi syndrome and Beige proteins genetic 1 1 1 Phenotypic Enhancement
AIM26 YKL037W Protein of unknown function genetic 1 1 1 Negative Genetic
ALT1 YLR089C Alanine transaminase (glutamic pyruvic transaminase) genetic 1 1 1 Negative Genetic
ARO2 YGL148W Bifunctional chorismate synthase and flavin reductase genetic 1 1 1 Phenotypic Enhancement
ATG21 YPL100W Phosphoinositide binding protein genetic 1 1 1 Phenotypic Enhancement
CMK2 YOL016C Calmodulin-dependent protein kinase physical 1 1 1 Affinity Capture-MS
CMK2 YOL016C Calmodulin-dependent protein kinase genetic 1 1 1 Dosage Rescue
AVT3 YKL146W Vacuolar transporter genetic 1 1 1 Phenotypic Enhancement
AIM34 YMR003W Protein of unknown function genetic 1 1 1 Negative Genetic
ATG15 YCR068W Phospholipase genetic 1 1 1 Phenotypic Enhancement
ALG9 YNL219C Mannosyltransferase, involved in N-linked glycosylation genetic 1 1 1 Positive Genetic
COX9 YDL067C Subunit VIIa of cytochrome c oxidase (Complex IV) genetic 1 1 1 Negative Genetic
AVT5 YBL089W Putative transporter genetic 1 1 1 Phenotypic Enhancement
ADY2 YCR010C Acetate transporter required for normal sporulation genetic 1 1 1 Negative Genetic
CBT1 YKL208W Protein involved in 5' RNA end processing genetic 1 1 1 Negative Genetic
BUD25 YER014C-A Protein involved in bud-site selection genetic 1 1 1 Phenotypic Enhancement
ASP3-3 YLR158C Cell-wall L-asparaginase II involved in asparagine catabolism genetic 1 1 1 Negative Genetic